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Conserved domains on  [gi|223539402|gb|EEF40992|]
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abhydrolase domain containing, putative [Ricinus communis]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-176 6.54e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 81.97  E-value: 6.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  52 MSPCTIDLDDqTTLHFWVTNRrqfNRPNLVLIHGYGGNSrWQFLNQVRPLSKSFNLYIPDLLFFGDSYTNRTDRSDIFQA 131
Cdd:COG0596    2 STPRFVTVDG-VRLHYREAGP---DGPPVVLLHGLPGSS-YEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 223539402 132 KCASEGLKKLGVEKYNVVGISYGGYVAYYMAENFNDEVKKVVIVS 176
Cdd:COG0596   77 DDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD 121
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-176 6.54e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 81.97  E-value: 6.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  52 MSPCTIDLDDqTTLHFWVTNRrqfNRPNLVLIHGYGGNSrWQFLNQVRPLSKSFNLYIPDLLFFGDSYTNRTDRSDIFQA 131
Cdd:COG0596    2 STPRFVTVDG-VRLHYREAGP---DGPPVVLLHGLPGSS-YEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 223539402 132 KCASEGLKKLGVEKYNVVGISYGGYVAYYMAENFNDEVKKVVIVS 176
Cdd:COG0596   77 DDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD 121
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 78-176 5.56e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 71.77  E-value: 5.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402   78 PNLVLIHGYGGNSrWQFLNQVRPLSKS-FNLYIPDLLFFGDS--YTNRTDRSDIFQAKCASEGLKKLGVEKYNVVGISYG 154
Cdd:pfam00561   1 PPVLLLHGLPGSS-DLWRKLAPALARDgFRVIALDLRGFGKSsrPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100
                  ....*....|....*....|..
gi 223539402  155 GYVAYYMAENFNDEVKKVVIVS 176
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLG 101
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 76-193 9.01e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 46.06  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  76 NRPNLVLIHGYGGNSRWQFLNqVRPLSKSFNLYIPDLLFFGDS----YTNR-TDRSDIFQAKCASEGLKKLGVEKYNVVG 150
Cdd:PLN02894 104 DAPTLVMVHGYGASQGFFFRN-FDALASRFRVIAIDQLGWGGSsrpdFTCKsTEETEAWFIDSFEEWRKAKNLSNFILLG 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223539402 151 ISYGGYVAYYMAENFNDEVKKVVIV-SCGICYTEEQREEQLRKL 193
Cdd:PLN02894 183 HSFGGYVAAKYALKHPEHVQHLILVgPAGFSSESDDKSEWLTKF 226
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 52-176 6.54e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 81.97  E-value: 6.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  52 MSPCTIDLDDqTTLHFWVTNRrqfNRPNLVLIHGYGGNSrWQFLNQVRPLSKSFNLYIPDLLFFGDSYTNRTDRSDIFQA 131
Cdd:COG0596    2 STPRFVTVDG-VRLHYREAGP---DGPPVVLLHGLPGSS-YEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 223539402 132 KCASEGLKKLGVEKYNVVGISYGGYVAYYMAENFNDEVKKVVIVS 176
Cdd:COG0596   77 DDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD 121
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 78-176 5.56e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 71.77  E-value: 5.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402   78 PNLVLIHGYGGNSrWQFLNQVRPLSKS-FNLYIPDLLFFGDS--YTNRTDRSDIFQAKCASEGLKKLGVEKYNVVGISYG 154
Cdd:pfam00561   1 PPVLLLHGLPGSS-DLWRKLAPALARDgFRVIALDLRGFGKSsrPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100
                  ....*....|....*....|..
gi 223539402  155 GYVAYYMAENFNDEVKKVVIVS 176
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLG 101
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
51-176 5.59e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 57.32  E-value: 5.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  51 SMSPCTIDLDDQTTLHFWVTNRRQFNRPNLVLIHGYGGNS-RWQFLnqVRPLSKS-FNLYIPDLLFFGDSYTNRTDRSDI 128
Cdd:COG2267    2 TRRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSgRYAEL--AEALAAAgYAVLAFDLRGHGRSDGPRGHVDSF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223539402 129 FQ----AKCASEGLKKLGVEKYNVVGISYGGYVAYYMAENFNDEVKKVVIVS 176
Cdd:COG2267   80 DDyvddLRAALDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLA 131
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
56-216 9.96e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 48.09  E-value: 9.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  56 TIDLDDQTTLHFWVTN-RRQFNRPNLVLIHGYGGNSRWQFLNQVRPL-SKSFNLYIPDLLFFGDSyTNRTDRSDIFQAKC 133
Cdd:COG1506    1 TFKSADGTTLPGWLYLpADGKKYPVVVYVHGGPGSRDDSFLPLAQALaSRGYAVLAPDYRGYGES-AGDWGGDEVDDVLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402 134 ASEGLKKLGV---EKYNVVGISYGGYVAYYMAENFNDEVkKVVIVSCGICYteeqreeqLRKLGRNNNIYDLLVPRKPED 210
Cdd:COG1506   80 AIDYLAARPYvdpDRIGIYGHSYGGYMALLAAARHPDRF-KAAVALAGVSD--------LRSYYGTTREYTERLMGGPWE 150


                 ....*.
gi 223539402 211 AREMLK 216
Cdd:COG1506  151 DPEAYA 156
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
81-176 5.77e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 46.09  E-value: 5.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  81 VLIHGYGGNSrwqflNQVRPLSKS-----FNLYIPDLLFFGDSYT--NRTDRSDIFQAkcASEGLKKL--GVEKYNVVGI 151
Cdd:COG1647   19 LLLHGFTGSP-----AEMRPLAEAlakagYTVYAPRLPGHGTSPEdlLKTTWEDWLED--VEEAYEILkaGYDKVIVIGL 91

                         90       100
                 ....*....|....*....|....*
gi 223539402 152 SYGGYVAYYMAENFnDEVKKVVIVS 176
Cdd:COG1647   92 SMGGLLALLLAARY-PDVAGLVLLS 115
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 76-193 9.01e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 46.06  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  76 NRPNLVLIHGYGGNSRWQFLNqVRPLSKSFNLYIPDLLFFGDS----YTNR-TDRSDIFQAKCASEGLKKLGVEKYNVVG 150
Cdd:PLN02894 104 DAPTLVMVHGYGASQGFFFRN-FDALASRFRVIAIDQLGWGGSsrpdFTCKsTEETEAWFIDSFEEWRKAKNLSNFILLG 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223539402 151 ISYGGYVAYYMAENFNDEVKKVVIV-SCGICYTEEQREEQLRKL 193
Cdd:PLN02894 183 HSFGGYVAAKYALKHPEHVQHLILVgPAGFSSESDDKSEWLTKF 226
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 80-176 5.22e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.78  E-value: 5.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  80 LVLIHGYGGN-SRWQFLnqVRPLSKSFNLYIPDLLFFGDSyTNRTDRSDI-FQAKCASEGLKKLGVEKYNVVGISYGGYV 157
Cdd:PRK14875 134 VVLIHGFGGDlNNWLFN--HAALAAGRPVIALDLPGHGAS-SKAVGAGSLdELAAAVLAFLDALGIERAHLVGHSMGGAV 210

                         90
                 ....*....|....*....
gi 223539402 158 AYYMAENFNDEVKKVVIVS 176
Cdd:PRK14875 211 ALRLAARAPQRVASLTLIA 229
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 80-162 1.80e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 41.31  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402   80 LVLIHGYggnsrWQFLNQVRPL-SKSFNLYIPDLLFFGDSYTNRTDRSDIFQAKCASEGLKklGVEKYNVVGISYGGYVA 158
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALlAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELG--AARPVVLVGHSLGGAVA 73


                  ....
gi 223539402  159 YYMA 162
Cdd:pfam12697  74 LAAA 77
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 56-176 3.42e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 40.67  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  56 TIDLDDQTTLH--FWVTNRRQFNRPNLVLIHGYGGNsRWQFLNQVRPLSK-SFNLYIPDLLFFGDS---YTNRTDRsDIF 129
Cdd:COG1073   14 TFKSRDGIKLAgdLYLPAGASKKYPAVVVAHGNGGV-KEQRALYAQRLAElGFNVLAFDYRGYGESegePREEGSP-ERR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223539402 130 QAKCA-SEGLKKLGVEKYNVV--GISYGG-YVAYYMAEnfNDEVKKVVIVS 176
Cdd:COG1073   92 DARAAvDYLRTLPGVDPERIGllGISLGGgYALNAAAT--DPRVKAVILDS 140
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
79-188 6.90e-04

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 40.00  E-value: 6.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  79 NLVLIHGYGGNSR-WQFLNQvrPLSKSFNLYIPDLLFFGdsytnrtdRSDIFQAKC---ASEGLKKLGVEKYNVVGISYG 154
Cdd:PRK10349  15 HLVLLHGWGLNAEvWRCIDE--ELSSHFTLHLVDLPGFG--------RSRGFGALSladMAEAVLQQAPDKAIWLGWSLG 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 223539402 155 GYVAYYMAENFNDEVKKVVIVSCGICYTeeQREE 188
Cdd:PRK10349  85 GLVASQIALTHPERVQALVTVASSPCFS--ARDE 116
PLN02578 PLN02578
hydrolase
 73-175 2.41e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 38.67  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  73 RQFNRPNLVLIHGYGGNS-RWQFlnQVRPLSKSFNLYIPDLLFFGDS------YTNRTDRSDIfqAKCASEGLKKLGVek 145
Cdd:PLN02578  82 VQGEGLPIVLIHGFGASAfHWRY--NIPELAKKYKVYALDLLGFGWSdkalieYDAMVWRDQV--ADFVKEVVKEPAV-- 155

                         90       100       110
                 ....*....|....*....|....*....|
gi 223539402 146 ynVVGISYGGYVAYYMAENFNDEVKKVVIV 175
Cdd:PLN02578 156 --LVGNSLGGFTALSTAVGYPELVAGVALL 183
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 76-162 2.69e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 37.90  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  76 NRPNLVLIHGYGGNSR-WQflnQVRPLSKSFN-LYIpDLLFFGDSytnRTDRSDIFQAKCA--SEGLKKLGVEKYNVVGI 151
Cdd:PRK11126   1 GLPWLVFLHGLLGSGQdWQ---PVGEALPDYPrLYI-DLPGHGGS---AAISVDGFADVSRllSQTLQSYNILPYWLVGY 73

                         90
                 ....*....|.
gi 223539402 152 SYGGYVAYYMA 162
Cdd:PRK11126  74 SLGGRIAMYYA 84
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 76-173 5.66e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.58  E-value: 5.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223539402  76 NRPNLVLIHGYGGNSRwQFLNQVRPLSKS-FNLYIPDLLFFGDSYTNRTD--RSDIFQAkcasegLKKLGVEKYNVVGIS 152
Cdd:COG1075    4 TRYPVVLVHGLGGSAA-SWAPLAPRLRAAgYPVYALNYPSTNGSIEDSAEqlAAFVDAV------LAATGAEKVDLVGHS 76

                         90       100
                 ....*....|....*....|...
gi 223539402 153 YGGYVAYYMAENF--NDEVKKVV 173
Cdd:COG1075   77 MGGLVARYYLKRLggAAKVARVV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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