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Conserved domains on  [gi|221236286|ref|YP_002518723|]
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phosphoribosylamidoimidazole-succinocarboxamide synthase [Caulobacter vibrioides NA1000]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10793682)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 4-320 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


:

Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 593.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   4 SAPNALAVVDLPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCAVPGKGQVLTETARFWFDATADICPNHVVAY 83
Cdd:PRK12607   2 MLPRTLTEFNFPELPNVYRGKVRDNYDLPDGRRVMVATDRISAFDRVLPAIPYKGQVLNQTAAFWFEATKDICPNHVLAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  84 PDPNVLIGKRLKMLPVELVVRGYLAGTTstsiLTLYNKGERQMYGVTLPDGLKANQRLPQAILTPTSKAADGDHDAPLSP 163
Cdd:PRK12607  82 PDPNVVVGKRCEPFPVEMVVRGYLAGST----WRLYKAGKREMYGVTLPDGLRENQKLPEPIITPTTKAEEGGHDEPISP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 164 DEVLAQGLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYEARFEA 243
Cdd:PRK12607 158 EEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIHTPDSSRYWYADGYEERFAA 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221236286 244 GQRPESFDKDFVRAWVAERCDPYNDSIPEIPAELIAQASAVYIEAFEAITGQTFAAPDAsEPVMARVKRNLDAYLAG 320
Cdd:PRK12607 238 GEPQEQLDKEFVRQWLIERCGPYGQEIPEIPDEVIVSVSERYIELYEKITGETFVPDSG-SPPLARIRKNLAAYLAR 313
 
Name Accession Description Interval E-value
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 4-320 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 593.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   4 SAPNALAVVDLPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCAVPGKGQVLTETARFWFDATADICPNHVVAY 83
Cdd:PRK12607   2 MLPRTLTEFNFPELPNVYRGKVRDNYDLPDGRRVMVATDRISAFDRVLPAIPYKGQVLNQTAAFWFEATKDICPNHVLAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  84 PDPNVLIGKRLKMLPVELVVRGYLAGTTstsiLTLYNKGERQMYGVTLPDGLKANQRLPQAILTPTSKAADGDHDAPLSP 163
Cdd:PRK12607  82 PDPNVVVGKRCEPFPVEMVVRGYLAGST----WRLYKAGKREMYGVTLPDGLRENQKLPEPIITPTTKAEEGGHDEPISP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 164 DEVLAQGLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYEARFEA 243
Cdd:PRK12607 158 EEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIHTPDSSRYWYADGYEERFAA 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221236286 244 GQRPESFDKDFVRAWVAERCDPYNDSIPEIPAELIAQASAVYIEAFEAITGQTFAAPDAsEPVMARVKRNLDAYLAG 320
Cdd:PRK12607 238 GEPQEQLDKEFVRQWLIERCGPYGQEIPEIPDEVIVSVSERYIELYEKITGETFVPDSG-SPPLARIRKNLAAYLAR 313
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 20-294 1.35e-134

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 383.05  E-value: 1.35e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  20 HYRGKVRDNYDLPDGRRVIVASDRLSAFDRNL-CAVPGKGQVLTETARFWFDATADICPNHVV-------------AYPD 85
Cdd:cd01414    2 IYSGKVRDVYDLGDGRLLFVATDRISAFDVILpPDIPGKGEVLTQISAFWFELTEDIIPNHLIstdvedlpeikepEDPD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  86 PNVLIGKRLKMLPVELVVRGYLAGTTSTSiltlYNKGERqMYGVTLPDGLKANQRLPQAILTPTSKAADGdHDAPLSPDE 165
Cdd:cd01414   82 GRSMVVKKAKPIPIECIVRGYLTGSGWKE----YQKGGT-VCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HDENISFEE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 166 VLAQglVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYearfEAGQ 245
Cdd:cd01414  156 AVEI--IGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSY----EPGK 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 221236286 246 RPESFDKDFVRAWVAERCDPYNDS-IPEIPAELIAQASAVYIEAFEAITG 294
Cdd:cd01414  230 EQPSFDKQFVRDWLEASGWDKQDPpPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 14-296 4.19e-116

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 335.13  E-value: 4.19e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  14 LPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIG 91
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDpIPGKGEVLNQISAFWFELLEDIgIPTHFIETLSGREMLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  92 KRLKMLPVELVVRGYLAGttstSILTLYNKGerqmygVTLPDGLKANQRLPQAILTPTSKAADGdHDAPLSPDEVLAQGL 171
Cdd:COG0152   81 KKLEMIPVEVVVRNYAAG----SLWKRYQAG------IALPLGLEEGTKLPEPIFEPSTKADEG-HDPNISEEHIVALGL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 172 VTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYearfeagqrpESFD 251
Cdd:COG0152  150 ATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTY----------ESLD 218

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 221236286 252 KDFVRAWvaercdpyndsipeipaeLIAQASAVYIEAFEAITGQT 296
Cdd:COG0152  219 KDRFRDW------------------LGGNTSEAYIEVLERLTGEK 245
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 21-268 1.01e-103

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 302.74  E-value: 1.01e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   21 YRGKVRDNYDLPD-GRRVIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIGKRLKML 97
Cdd:pfam01259   3 YEGKVKDVYETDDpDTLLVVAKDRISAFDGVKKGtIPGKGAVNNQISAFWFELLEIAgIPTHFIKSLSGREMLVKKVKII 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   98 PVELVVRGYLAGTTSTsiltlynkgerqmygvTLPdGLKANQRLPQAILTPTSKAADGdHDAPLSPDEVLAQGLVTPAQW 177
Cdd:pfam01259  83 PLEVVVRNYAAGSLGK----------------RLP-GLKEGTKLPEPIFEPSTKADAL-GDPNINEEHIVALGLATEEEA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  178 EQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYEarfeagQRPESFDKDFVRA 257
Cdd:pfam01259 145 EEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYE------KSQESLDKDRFRD 217

                         250
                  ....*....|.
gi 221236286  258 WVAERCDPYND 268
Cdd:pfam01259 218 DLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 21-256 9.00e-49

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 162.95  E-value: 9.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   21 YRGKVRDNYDLPDGRR-VIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIGKRLKML 97
Cdd:TIGR00081  10 YSGKAKDIYETDDPDLlRFVFRDDISAFDGEKKDqIPGKGRLNTKISAFIFEKLEEAgIPTHYIDLIEDREMLVKKLDII 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   98 PVELVVRGYLAGttstSILtlynkgeRQMygvTLPDGLKANQRLPQAILTPtskAADGDHDapLSPDEVLAQGLVTPAQW 177
Cdd:TIGR00081  90 PLEVIVRNIAAG----SLL-------KRL---GIPEGLELEQPLVEFIFKP---DEVGDPM--LNESYAEALGLATEEEL 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221236286  178 EQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYearfEAGQRPesFDKDFVR 256
Cdd:TIGR00081 151 ERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETY----EVGAPK--LDKDIFR 222
 
Name Accession Description Interval E-value
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 4-320 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 593.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   4 SAPNALAVVDLPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCAVPGKGQVLTETARFWFDATADICPNHVVAY 83
Cdd:PRK12607   2 MLPRTLTEFNFPELPNVYRGKVRDNYDLPDGRRVMVATDRISAFDRVLPAIPYKGQVLNQTAAFWFEATKDICPNHVLAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  84 PDPNVLIGKRLKMLPVELVVRGYLAGTTstsiLTLYNKGERQMYGVTLPDGLKANQRLPQAILTPTSKAADGDHDAPLSP 163
Cdd:PRK12607  82 PDPNVVVGKRCEPFPVEMVVRGYLAGST----WRLYKAGKREMYGVTLPDGLRENQKLPEPIITPTTKAEEGGHDEPISP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 164 DEVLAQGLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYEARFEA 243
Cdd:PRK12607 158 EEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEIHTPDSSRYWYADGYEERFAA 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221236286 244 GQRPESFDKDFVRAWVAERCDPYNDSIPEIPAELIAQASAVYIEAFEAITGQTFAAPDAsEPVMARVKRNLDAYLAG 320
Cdd:PRK12607 238 GEPQEQLDKEFVRQWLIERCGPYGQEIPEIPDEVIVSVSERYIELYEKITGETFVPDSG-SPPLARIRKNLAAYLAR 313
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 4-314 2.95e-144

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 411.14  E-value: 2.95e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   4 SAPNALAVVDL----PCLPNHYRGKVRDNYDLPDgRRVIVASDRLSAFDRNLCAVPGKGQVLTETARFWFDATADICPNH 79
Cdd:PLN02544  58 ALSNCLTETNLdltvPGLGSRRRGKVRDIYDLGD-YLVLVTTDRQSAFDRVLASIPFKGQVLNQTSAWWFNNTKHITPNA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  80 VVAYPDPNVLIGKRLKMLPVELVVRGYLAGTTSTSILTLYNKGERQMYGVTLPDGLKANQRLPQAILTPTSKAADgdHDA 159
Cdd:PLN02544 137 LVSSPDPNVTIAKKCSVFPVEFVVRGYMTGSTSTSLWTVYNKGVRNYCGNDLPDGMVKNQKLPANILTPTTKAAD--HDV 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 160 PLSPDEVLAQGLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYEA 239
Cdd:PLN02544 215 PISPEEIVEEGLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDEVHTPDSSRYWLADSYEE 294

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221236286 240 RFEAGQRPESFDKDFVRAWVAERCDPYNDS-IPEIPAELIAQASAVYIEAFEAITGQTFAAPDASEPVMARVKRNL 314
Cdd:PLN02544 295 RHAAGLEPENIDKEFLRLWFKENCDPYKDEvLPEAPAELVCELSWRYIKLYETITGEKFEVPDTQEPIHERISRNV 370
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 20-294 1.35e-134

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 383.05  E-value: 1.35e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  20 HYRGKVRDNYDLPDGRRVIVASDRLSAFDRNL-CAVPGKGQVLTETARFWFDATADICPNHVV-------------AYPD 85
Cdd:cd01414    2 IYSGKVRDVYDLGDGRLLFVATDRISAFDVILpPDIPGKGEVLTQISAFWFELTEDIIPNHLIstdvedlpeikepEDPD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  86 PNVLIGKRLKMLPVELVVRGYLAGTTSTSiltlYNKGERqMYGVTLPDGLKANQRLPQAILTPTSKAADGdHDAPLSPDE 165
Cdd:cd01414   82 GRSMVVKKAKPIPIECIVRGYLTGSGWKE----YQKGGT-VCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HDENISFEE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 166 VLAQglVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYearfEAGQ 245
Cdd:cd01414  156 AVEI--IGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSY----EPGK 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 221236286 246 RPESFDKDFVRAWVAERCDPYNDS-IPEIPAELIAQASAVYIEAFEAITG 294
Cdd:cd01414  230 EQPSFDKQFVRDWLEASGWDKQDPpPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 14-296 4.19e-116

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 335.13  E-value: 4.19e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  14 LPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIG 91
Cdd:COG0152    1 MPKLELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDpIPGKGEVLNQISAFWFELLEDIgIPTHFIETLSGREMLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  92 KRLKMLPVELVVRGYLAGttstSILTLYNKGerqmygVTLPDGLKANQRLPQAILTPTSKAADGdHDAPLSPDEVLAQGL 171
Cdd:COG0152   81 KKLEMIPVEVVVRNYAAG----SLWKRYQAG------IALPLGLEEGTKLPEPIFEPSTKADEG-HDPNISEEHIVALGL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 172 VTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYearfeagqrpESFD 251
Cdd:COG0152  150 ATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLWDADTY----------ESLD 218

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 221236286 252 KDFVRAWvaercdpyndsipeipaeLIAQASAVYIEAFEAITGQT 296
Cdd:COG0152  219 KDRFRDW------------------LGGNTSEAYIEVLERLTGEK 245
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 13-298 9.40e-105

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 308.28  E-value: 9.40e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  13 DLPCLPNHYRGKVRDNYDLPDGRRVIVASDRLSAFDRNL-CAVPGKGQVLTETARFWFDATADICPNHVVAYPDPNV--- 88
Cdd:PRK13961   8 DLPSLPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILpEPIPDKGRVLTQMSNFWFDKLAHIVPNHLTGIDVDDVvpa 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  89 ----------LIGKRLKMLPVELVVRGYLAGttstSILTLYNKgERQMYGVTLPDGLKANQRLPQAILTPTSKAADGDHD 158
Cdd:PRK13961  88 deadqvlgraVVVKKLKPLPVECVVRGYLTG----SGWKDYQA-TGTVCGIKLPAGLVEASKLPEPIFTPATKAELGDHD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 159 APLSPDEVLAqgLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIHTPDSSRFWKAATYe 238
Cdd:PRK13961 163 ENISFEEVVE--LVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPDSSRFWPADSY- 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 239 arfEAGQRPESFDKDFVRAWVAERCDPYNDSIPEIPAELIAQASAVYIEAFEAITGQTFA 298
Cdd:PRK13961 240 ---QPGTSQPSFDKQFVRDWLETSGWDKTAPAPPLPADVIEKTRAKYREALERLTGKSLD 296
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 21-268 1.01e-103

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 302.74  E-value: 1.01e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   21 YRGKVRDNYDLPD-GRRVIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIGKRLKML 97
Cdd:pfam01259   3 YEGKVKDVYETDDpDTLLVVAKDRISAFDGVKKGtIPGKGAVNNQISAFWFELLEIAgIPTHFIKSLSGREMLVKKVKII 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   98 PVELVVRGYLAGTTSTsiltlynkgerqmygvTLPdGLKANQRLPQAILTPTSKAADGdHDAPLSPDEVLAQGLVTPAQW 177
Cdd:pfam01259  83 PLEVVVRNYAAGSLGK----------------RLP-GLKEGTKLPEPIFEPSTKADAL-GDPNINEEHIVALGLATEEEA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  178 EQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYEarfeagQRPESFDKDFVRA 257
Cdd:pfam01259 145 EEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYE------KSQESLDKDRFRD 217

                         250
                  ....*....|.
gi 221236286  258 WVAERCDPYND 268
Cdd:pfam01259 218 DLGDVEEAYQE 228
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 21-256 9.00e-49

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 162.95  E-value: 9.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   21 YRGKVRDNYDLPDGRR-VIVASDRLSAFDRNLCA-VPGKGQVLTETARFWFDATADI-CPNHVVAYPDPNVLIGKRLKML 97
Cdd:TIGR00081  10 YSGKAKDIYETDDPDLlRFVFRDDISAFDGEKKDqIPGKGRLNTKISAFIFEKLEEAgIPTHYIDLIEDREMLVKKLDII 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   98 PVELVVRGYLAGttstSILtlynkgeRQMygvTLPDGLKANQRLPQAILTPtskAADGDHDapLSPDEVLAQGLVTPAQW 177
Cdd:TIGR00081  90 PLEVIVRNIAAG----SLL-------KRL---GIPEGLELEQPLVEFIFKP---DEVGDPM--LNESYAEALGLATEEEL 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221236286  178 EQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYearfEAGQRPesFDKDFVR 256
Cdd:TIGR00081 151 ERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADEV-SPDTCRLWDKETY----EVGAPK--LDKDIFR 222
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 21-263 3.54e-39

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 137.98  E-value: 3.54e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  21 YRGKVRDNYDLPDGRRVIVASDRLSAFDRNLCAV-PGKGQVLTETARFWFD--ATADIcPNHVVAYPDPNVLIGKRLKML 97
Cdd:cd00476    3 YRGKTKIVYETKDGVLLLEFKDDISAGDGARRNFlDEKGDITAKLTLFIFKylSEAGI-PTHFVERLGPRTLLVDKLK*I 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  98 PVELVVRGYLAGTTStsiltlynkgerQMYGvtlpdGLKANQRLPQAILTPTSKAaDGDHDAPLSPDEVLAQGLVTPAQW 177
Cdd:cd00476   82 PLEVVVRNRATGSFV------------KRYG-----GFKEGREFPPPLVEFFYKD-DAEHDPIVSEDQLERLGFIGKVDV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 178 EQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATYEARFEAGQRPESFDKDFVR- 256
Cdd:cd00476  144 ER*KELAVKINTVLKKLFSPAGLELWDFKLEFGLDEEGEIVLGDEI-SPDSSRLWRKGGEPYDKDLFRRRASLGQIIEKy 222


                 ....*..
gi 221236286 257 AWVAERC 263
Cdd:cd00476  223 EEVAELV 229
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-301 9.66e-32

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 121.74  E-value: 9.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286   1 MTLsAPNALAVV-DLPC---LPNHyRGKVRDNYDL--PDGRRVI----------------VASDRLSAFD------RNLC 52
Cdd:PRK13960   1 MSL-ADKVLAVNdDLPIrtdKPVH-SGKVRSVYWLteEDSRRLIkekgynvpadaplaimVISDRISAFDciwhgeGGLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  53 AVPGKGQVLTETARFWFDATAD--ICPNHVVAYPDPNVLIGKRLKMLPVELVVRGYLAGttstSILTLYNKGERQMYGVT 130
Cdd:PRK13960  79 GVPGKGAALNAISNHWFKLFKEngLADSHILDIPHPFVWIVQKARPVMIEAICRQYITG----SMWRAYSKGEREFCGIT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 131 LPDGLKANQRLPQAILTPTSK----------AADgdhDAPLS----PDEVLAQGLVTP---AQWEQLSAYALALFArgQA 193
Cdd:PRK13960 155 LPEGLEKDQKLPELLITPSTKgiltgipgvpEAD---DVNISrsdiEANYQAFNFSSAddiDLYEKLLKEGFKVIS--DA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 194 MaAERGLILADTKYEFGL--DETGA--IVLADEIHTPDSSRFWKAATYearfEAGQRPESFDKDFvRAWVAERC-DP--- 265
Cdd:PRK13960 230 L-AKLDQIFVDTKFEFGYvtDAAGNekLIYMDEVGTPDSSRIWDGAAY----RDGKIVENSKEGF-RQFLLNHFpDPdil 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 221236286 266 -YNDSIPE---------IPAELIAQASAVYIEAFEAITGQTFAAPD 301
Cdd:PRK13960 304 lNKDRMPErealardnaLPLEAMMDVSRTYTGIAEKITGAKIVLSA 349
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 21-256 4.24e-29

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 111.39  E-value: 4.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  21 YRGKVRDNYDLPDGRRVIVA-SDRLSAFDrnlcA-----VPGKGQVLTETARFWFD--ATADIcPNHVVAYPDPNVLIGK 92
Cdd:cd01415    3 YEGKAKIVYATDDPDVLIVEfKDDATAFN----GkkkdtIEGKGVLNNEISALIFKylEENGI-KTHFIEKLSDREQLVK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  93 RLKMLPVELVVRGYLAGttstSILtlynkgeRQMygvtlpdGLKANQRLPQAILTPTSKAaDGDHDAPLSPDEVLAQGLV 172
Cdd:cd01415   78 KVEIIPLEVVVRNIAAG----SLV-------KRL-------GIEEGTVLDPPIVEFYYKN-DELGDPLINEDHILALGLA 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 173 TPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATyearfeagqrPESFDK 252
Cdd:cd01415  139 TEEELKEIKELALKINEVLSEFFAEIGIILVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDKET----------GEKLDK 207


                 ....
gi 221236286 253 DFVR 256
Cdd:cd01415  208 DRFR 211
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 21-253 1.39e-26

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 104.80  E-value: 1.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  21 YRGKVRDNYDLPDGRRVIVA-SDRLSAFDrnlcA-----VPGKGQVLTETARFWFD--ATADIcPNHVVAYPDPNVLIGK 92
Cdd:PRK09362   8 YEGKAKIVYSTDDPDLLIVEfKDDATAFN----GekkeqIDGKGVLNNQISSFIFKklEEAGI-PTHFIEKLSDREQLVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  93 RLKMLPVELVVRGYLAGttstSILtlynkgeRQMygvtlpdGLKANQRLPQAILTPTSKAaDGDHDAPLSPDEVLAQGLV 172
Cdd:PRK09362  83 KVEIIPLEVVVRNVAAG----SLV-------KRL-------GIEEGTVLPPPIVEFYYKN-DALGDPMINEDHILALGWA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 173 TPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLDETGAIVLADEIhTPDSSRFWKAATyearfeagqrPESFDK 252
Cdd:PRK09362 144 TPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADEI-SPDTCRLWDKET----------NEKLDK 212


                 .
gi 221236286 253 D 253
Cdd:PRK09362 213 D 213
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 22-312 2.21e-19

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 87.04  E-value: 2.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  22 RGKVRDNYDLPD------GRRVIVASDRLSAFDRNLC--AVPGKGQVLTETARFWFDATAD-ICPNHVVAYPD------- 85
Cdd:PRK13959   1 MGSVKDFYVDEEptetdlGRGRFVFSDRYSVFDWGIMpdEIPDKGASLCTMGAYNFELLEEeGIKTHYIGVVEdgevvrl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  86 ------PNVLIGKRLK------------------------MLPVELVVRGYLAGTTStsiltLYnkgERQMYGVTLPD-- 133
Cdd:PRK13959  81 aeasepPNEMAVKLTQvpdlpfeggsydydayheaagenyLIPLEVIFRNYVPVGSS-----LR---DRIKEGKIKPEdl 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 134 GLKAN------QRLPQAILTPTSKAADgdHDAPLSPDEVLAQGLVTPAQWEQLSAYALALFARGQAMAAERGLILADTKY 207
Cdd:PRK13959 153 GLDADewpeegVKLPEPIVEFSTKYEE--QDRYLSRKEADEIAGLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 208 EFGLDETGAIVLADEIHTPDSSRF--------------------WKAATYEArfeagqrpesfdKDFVRAWVAERCDPyn 267
Cdd:PRK13959 231 EFALYEEREIRVVDVVGTFDENRFsyegqelskevvrqyyrrteWVEAVKEA------------KEEDVADWRSLCEP-- 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 221236286 268 dSIPEIPAELIAQASAVYIEAFEAITGQT-FAAPDASEpVMARVKR 312
Cdd:PRK13959 297 -DPPPLPDEVVEAVSDLYKAGTNAYTGREwFDAPPLKD-AVDRVRE 340
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 23-264 2.47e-14

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 71.55  E-value: 2.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  23 GKVRDNYDLPD--GRRVIVASDRLSAFD---RNlcAVPGKGQVLTET--ARFWFDATADIcPNHVVAYPDPNVLIGKRLK 95
Cdd:cd01416   10 GKTKIVYELPDqpGLVLIQSKDRITAGDgarKD--EIEGKAAISNKTtsNVFELLQEAGI-KTHFVKQCSPTAFIARKCE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286  96 MLPVELVVRGYLAGttstSILTLYnkgerqmygvtlpDGLKANQRLPQAILTPTSKAaDGDHDAPLSPDEVLAQGL---- 171
Cdd:cd01416   87 MIPIEWVCRRIATG----SFLKRN-------------PGVKEGYRFSPPKLEFFYKD-DANHDPQWSEEQLLEAKLncgg 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221236286 172 --VTPAQWEQLSAYALALFARGQAMAAERGLILADTKYEFGLD-ETGAIVLADEIHTpDSSRFWKaatyearfeAGQRPE 248
Cdd:cd01416  149 lkIGKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDvTTGEILLADVIDN-DSWRLWP---------SGDKRL 218

                        250       260       270
                 ....*....|....*....|....*....|...
gi 221236286 249 SFDKDFVR-----------------AWVAERCD 264
Cdd:cd01416  219 MKDKQVYRnlkevtdealqevkknyEWVADKLE 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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