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Conserved domains on  [gi|221046468]
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Chain A, Solution structure of PFE0790c, a putative bolA-like protein from the protozoan parasite Plasmodium falciparum.

Protein Classification

BolA family protein( domain architecture ID 10000955)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like proteins that act as iron-sulfur (Fe-S) cluster assembly factors that facilitate [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Haemophilus influenzae DNA-binding transcriptional regulator BolA

CATH:  3.30.300.90

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 23-103 7.98e-25

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 440041  Cd Length: 90  Bit Score: 89.48  E-value: 7.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  23 MCIQKVIEDKLSSALKPTFLELVDKS--------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMK 93
Cdd:COG0271    1 MSRQERIEEKLTAALAPEHLEVIDEShlhaghagAGGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIH 80

                         90
                 ....*....|
gi 221046468  94 CHTPLEYDKL 103
Cdd:COG0271   81 AYTPEEWQAR 90
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 23-103 7.98e-25

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 89.48  E-value: 7.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  23 MCIQKVIEDKLSSALKPTFLELVDKS--------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMK 93
Cdd:COG0271    1 MSRQERIEEKLTAALAPEHLEVIDEShlhaghagAGGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIH 80

                         90
                 ....*....|
gi 221046468  94 CHTPLEYDKL 103
Cdd:COG0271   81 AYTPEEWQAR 90
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 33-99 7.51e-24

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 86.35  E-value: 7.51e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221046468   33 LSSALKPTFLELVDKS-------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMKCHTPLE 99
Cdd:pfam01722   1 LTEALAPTHLEVEDEShkhaghaGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 23-104 6.14e-17

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 69.81  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  23 MCIQKVIEDKLSSALKPTFLELVDKS------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMKCH 95
Cdd:PRK11628   1 MMIREQIEEKLRAAFQPVFLEVVDESyrhnvpAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTY 80


                 ....*....
gi 221046468  96 TPLEYDKLK 104
Cdd:PRK11628  81 TIKEWEGLQ 89
 
Name Accession Description Interval E-value
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 23-103 7.98e-25

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 89.48  E-value: 7.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  23 MCIQKVIEDKLSSALKPTFLELVDKS--------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMK 93
Cdd:COG0271    1 MSRQERIEEKLTAALAPEHLEVIDEShlhaghagAGGESHFKVVIVSDAFAGKSRVARHRLVYAALADELAGgIHALAIH 80

                         90
                 ....*....|
gi 221046468  94 CHTPLEYDKL 103
Cdd:COG0271   81 AYTPEEWQAR 90
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 33-99 7.51e-24

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 86.35  E-value: 7.51e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221046468   33 LSSALKPTFLELVDKS-------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMKCHTPLE 99
Cdd:pfam01722   1 LTEALAPTHLEVEDEShkhaghaGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAGgIHALSIKTYTPEE 75
PRK11628 PRK11628
transcriptional regulator BolA; Provisional
 23-104 6.14e-17

transcriptional regulator BolA; Provisional


Pssm-ID: 183243  Cd Length: 105  Bit Score: 69.81  E-value: 6.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  23 MCIQKVIEDKLSSALKPTFLELVDKS------CGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN-IHAFSMKCH 95
Cdd:PRK11628   1 MMIREQIEEKLRAAFQPVFLEVVDESyrhnvpAGSESHFKVVLVSDRFTGERFLNRHRMIYSTLAEELSTtVHALALHTY 80


                 ....*....
gi 221046468  96 TPLEYDKLK 104
Cdd:PRK11628  81 TIKEWEGLQ 89
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
29-106 2.84e-14

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 62.09  E-value: 2.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221046468  29 IEDKLSSALKPTFLELVdkscGCGTSFDAVIVSNNFEDKKLLDRHRLVNTILKEELQN--IHAFSMKCHTPLEYDKLKSK 106
Cdd:COG5007    6 IKQLIEAGLPCAEVEVE----GDGSHFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIASgeIHALSIKTYTPEEWAAQRKL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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