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Conserved domains on  [gi|221040094|dbj|BAH11810|]
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unnamed protein product [Homo sapiens]

Protein Classification

LysM peptidoglycan-binding domain-containing protein( domain architecture ID 10478509)

LysM peptidoglycan-binding domain-containing protein may bind N-acetylglucosamine in carbohydrates such as chitin, chitio-oligosaccharides and peptidoglycan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
665-827 3.10e-50

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 3.10e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   665 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 744
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   745 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 822
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160


                   ....*
gi 221040094   823 VWAFD 827
Cdd:smart00584 161 VWGFG 165
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
3-54 1.75e-09

LysM repeat [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 57.41  E-value: 1.75e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221040094   3 VQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 54
Cdd:COG1388  103 AAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
665-827 3.10e-50

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 3.10e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   665 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 744
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   745 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 822
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160


                   ....*
gi 221040094   823 VWAFD 827
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 691-826 5.53e-35

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 129.65  E-value: 5.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094  691 LAYSTLEHGTSLKTLYRKSASlDSPVLLVIKDMDNQIFGAYATHPFKFSDH-YYGTGETFLYTFSPHFKVFKWSGENSYF 769
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDN-KGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221040094  770 INGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSK--KEDFIVQDLEVWAF 826
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGL 138
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
680-824 1.13e-20

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 91.11  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094 680 LPARVQGY-PWRLAYSTLEHGTSLKTLYRKSASLDSPV-----LLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTF 753
Cdd:COG5142   49 LPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094 754 SP---------HFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFI-VQDLEV 823
Cdd:COG5142  129 ARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGHFFrIVYLEL 208


                 .
gi 221040094 824 W 824
Cdd:COG5142  209 W 209
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
3-54 1.75e-09

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 57.41  E-value: 1.75e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221040094   3 VQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 54
Cdd:COG1388  103 AAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 18-54 1.82e-08

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 50.86  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 221040094   18 DTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 54
Cdd:pfam01476   7 DTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 12-53 1.64e-06

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 45.55  E-value: 1.64e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 221040094  12 YTAGNQDTLNSIALKFNITPNKLVELNKLFT-HTIVPGQVLFV 53
Cdd:cd00118    3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINpDCIYPGQKLKI 45
LysM smart00257
Lysin motif;
18-53 3.41e-06

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 44.36  E-value: 3.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 221040094    18 DTLNSIALKFNITPNKLVELNKLF-THTIVPGQVLFV 53
Cdd:smart00257   8 DTLSSIARRYGISVSDLLELNNILdPDNLQVGQKLKI 44
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 12-53 7.50e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 39.72  E-value: 7.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 221040094  12 YTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFV 53
Cdd:PRK10783 346 YKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTI 387
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
665-827 3.10e-50

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 3.10e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   665 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 744
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094   745 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 822
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160


                   ....*
gi 221040094   823 VWAFD 827
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 691-826 5.53e-35

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 129.65  E-value: 5.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094  691 LAYSTLEHGTSLKTLYRKSASlDSPVLLVIKDMDNQIFGAYATHPFKFSDH-YYGTGETFLYTFSPHFKVFKWSGENSYF 769
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDN-KGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 221040094  770 INGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSK--KEDFIVQDLEVWAF 826
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGL 138
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
680-824 1.13e-20

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 91.11  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094 680 LPARVQGY-PWRLAYSTLEHGTSLKTLYRKSASLDSPV-----LLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTF 753
Cdd:COG5142   49 LPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221040094 754 SP---------HFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFI-VQDLEV 823
Cdd:COG5142  129 ARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGHFFrIVYLEL 208


                 .
gi 221040094 824 W 824
Cdd:COG5142  209 W 209
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
3-54 1.75e-09

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 57.41  E-value: 1.75e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221040094   3 VQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 54
Cdd:COG1388  103 AAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 18-54 1.82e-08

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 50.86  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 221040094   18 DTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 54
Cdd:pfam01476   7 DTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 12-53 1.64e-06

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 45.55  E-value: 1.64e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 221040094  12 YTAGNQDTLNSIALKFNITPNKLVELNKLFT-HTIVPGQVLFV 53
Cdd:cd00118    3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINpDCIYPGQKLKI 45
LysM smart00257
Lysin motif;
18-53 3.41e-06

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 44.36  E-value: 3.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 221040094    18 DTLNSIALKFNITPNKLVELNKLF-THTIVPGQVLFV 53
Cdd:smart00257   8 DTLSSIARRYGISVSDLLELNNILdPDNLQVGQKLKI 44
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 12-53 7.50e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 39.72  E-value: 7.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 221040094  12 YTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFV 53
Cdd:PRK10783 346 YKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTI 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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