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Conserved domains on  [gi|218511664|sp|P60369|]
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RecName: Full=Keratin-associated protein 10-3; AltName: Full=High sulfur keratin-associated protein 10.3; AltName: Full=Keratin-associated protein 10.3; AltName: Full=Keratin-associated protein 18-3; AltName: Full=Keratin-associated protein 18.3

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-174 5.77e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   22 CPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSpCCQAACEPSpCQSGCtssCTPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218511664  102 PVCCKPVCCVPVCCKPVCCKPICCVPVCSgaSSSCCQQSSRQPACCTTSCCRPSSsvsllCRPVCRSTCCVPI 174
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCT--PPTCCQLHHAQASCCRPSYCGQSC-----CRPACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-174 5.77e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   22 CPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSpCCQAACEPSpCQSGCtssCTPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218511664  102 PVCCKPVCCVPVCCKPVCCKPICCVPVCSgaSSSCCQQSSRQPACCTTSCCRPSSsvsllCRPVCRSTCCVPI 174
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCT--PPTCCQLHHAQASCCRPSYCGQSC-----CRPACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-174 5.77e-13

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 64.43  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   22 CPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSpCCQAACEPSpCQSGCtssCTPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218511664  102 PVCCKPVCCVPVCCKPVCCKPICCVPVCSgaSSSCCQQSSRQPACCTTSCCRPSSsvsllCRPVCRSTCCVPI 174
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCT--PPTCCQLHHAQASCCRPSYCGQSC-----CRPACCCQCSEPT 160
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-123 1.53e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 54.70  E-value: 1.53e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218511664   79 CCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPI 123
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
84-128 4.03e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 53.54  E-value: 4.03e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218511664   84 SCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPV 128
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-118 7.71e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 52.77  E-value: 7.71e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218511664   74 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPV 118
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 78-203 1.13e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.18  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   78 SCCQQSSCQ-PACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVCSGASS-SCCQQSSRQPACCTTSC---- 151
Cdd:pfam01500   2 ACCGTSFCGfPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqPCCQTSCCQPTCCQTSScqtg 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218511664  152 ---------------------CRPSSSVSLLCRPVCRSTCCVPiPSCCAPASTcQPSCCRPASCVSLLCRPTC 203
Cdd:pfam01500  82 cggigygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTP-PTCCQLHHA-QASCCRPSYCGQSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
72-113 2.83e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 2.83e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218511664   72 TSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPV 113
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
89-129 2.98e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 2.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 218511664   89 CCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVC 129
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
94-130 1.24e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.91  E-value: 1.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 218511664   94 PCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVCS 130
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCC 37
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-129 1.58e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 46.71  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664    4 STMSVCSSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLTLVCTPVScvsspccqAACEPSPCQSGCTSSCTPSCCQQS 83
Cdd:pfam01500  40 CQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGY--------GQEGSSGAVSSRTRWCRPDCRVEG 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 218511664   84 SCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVC 129
Cdd:pfam01500 112 TCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-124 6.64e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.78  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664    3 TSTMSVCSSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSPCCQAACepspcqsgCTSSCTPSCCQQ 82
Cdd:pfam01500  49 TFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCR--------VEGTCLPPCCVV 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 218511664   83 SSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPvCCKPIC 124
Cdd:pfam01500 121 SCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQ-CSEPTC 161
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-131 7.43e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 42.11  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   10 SSAYSDSWQVDACPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSpcCQAACEPSPCQSGCTSSCTPSCCQQSSCQPAC 89
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRS--CYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLG 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 218511664   90 CTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVCSG 131
Cdd:pfam05287 122 YGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSYVS 163
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
22-65 2.87e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 2.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218511664   22 CPESCCEPPCCATSCCAPAPCLTLVCTPVSCVSSPCCQAACEPS 65
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
146-202 3.33e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 3.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 218511664  146 CCTTSCCRPSssvsllcrpVCRSTCCVPipSCCAPaSTCQPSCCRPASCVSLLCRPT 202
Cdd:pfam13885   1 CCQPSCCQPS---------CCQPSCCQP--SCCQP-SCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 74-203 4.21e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 36.72  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218511664   74 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCKPVCCKPICCVPVCSGASSSCCQQSSRQPACCTTSCCR 153
Cdd:pfam05287  35 SYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGS 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 218511664  154 PSSSVSLLCRPVCRSTCCVpipSCCAPASTCQPSCCRPASCVSLLCRPTC 203
Cdd:pfam05287 115 SSCQSLGYGSNSCQPLGCG---SSGFRPLGCLSKGFQSLGYGSSFCRPSY 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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