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Conserved domains on  [gi|218203545|gb|ACK76129|]
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acetyl-coA carboxylase beta subunit, partial (chloroplast) [Rheum nanum]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 164-266 4.96e-52

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member CHL00174:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 296  Bit Score: 171.24  E-value: 4.96e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218203545 164 DSDNYIDNYIFdESQTTAKTNGRDKNLEvTKKYSNLWIQCENCYELNYKKLLKSKTNICDECGYHLKMSSSERIELSIDP 243
Cdd:CHL00174   4 DIRNLISNQIF-EIDNDSYMYDTKYSWN-TQKYKHLWVQCENCYGLNYKKFLKSKMNICEQCGYHLKMSSSDRIELLIDP 81

                         90       100
                 ....*....|....*....|...
gi 218203545 244 GTWDPMDEDMVSTDPIEFHSEEE 266
Cdd:CHL00174  82 GTWNPMDEDMVSLDPIEFHSDEE 104
 
Name Accession Description Interval E-value
accD CHL00174
acetyl-CoA carboxylase beta subunit; Reviewed
 164-266 4.96e-52

acetyl-CoA carboxylase beta subunit; Reviewed


Pssm-ID: 214384 [Multi-domain]  Cd Length: 296  Bit Score: 171.24  E-value: 4.96e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218203545 164 DSDNYIDNYIFdESQTTAKTNGRDKNLEvTKKYSNLWIQCENCYELNYKKLLKSKTNICDECGYHLKMSSSERIELSIDP 243
Cdd:CHL00174   4 DIRNLISNQIF-EIDNDSYMYDTKYSWN-TQKYKHLWVQCENCYGLNYKKFLKSKMNICEQCGYHLKMSSSDRIELLIDP 81

                         90       100
                 ....*....|....*....|...
gi 218203545 244 GTWDPMDEDMVSTDPIEFHSEEE 266
Cdd:CHL00174  82 GTWNPMDEDMVSLDPIEFHSDEE 104
AccD COG0777
Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase ...
 198-261 1.69e-19

Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase beta subunit is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440540 [Multi-domain]  Cd Length: 280  Bit Score: 85.11  E-value: 1.69e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218203545 198 NLWIQCENCYELNYKKLLKSKTNICDECGYHLKMSSSERIELSIDPGTWDPMDEDMVSTDPIEF 261
Cdd:COG0777   23 GLWTKCPSCGEILYRKELEENLYVCPKCGHHFRISARERLELLLDEGSFEELDADLVPVDPLKF 86
 
Name Accession Description Interval E-value
accD CHL00174
acetyl-CoA carboxylase beta subunit; Reviewed
 164-266 4.96e-52

acetyl-CoA carboxylase beta subunit; Reviewed


Pssm-ID: 214384 [Multi-domain]  Cd Length: 296  Bit Score: 171.24  E-value: 4.96e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218203545 164 DSDNYIDNYIFdESQTTAKTNGRDKNLEvTKKYSNLWIQCENCYELNYKKLLKSKTNICDECGYHLKMSSSERIELSIDP 243
Cdd:CHL00174   4 DIRNLISNQIF-EIDNDSYMYDTKYSWN-TQKYKHLWVQCENCYGLNYKKFLKSKMNICEQCGYHLKMSSSDRIELLIDP 81

                         90       100
                 ....*....|....*....|...
gi 218203545 244 GTWDPMDEDMVSTDPIEFHSEEE 266
Cdd:CHL00174  82 GTWNPMDEDMVSLDPIEFHSDEE 104
AccD COG0777
Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase ...
 198-261 1.69e-19

Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase beta subunit is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440540 [Multi-domain]  Cd Length: 280  Bit Score: 85.11  E-value: 1.69e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218203545 198 NLWIQCENCYELNYKKLLKSKTNICDECGYHLKMSSSERIELSIDPGTWDPMDEDMVSTDPIEF 261
Cdd:COG0777   23 GLWTKCPSCGEILYRKELEENLYVCPKCGHHFRISARERLELLLDEGSFEELDADLVPVDPLKF 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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