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Conserved domains on  [gi|218169099|gb|ACK67836|]
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acetate kinase [Rippkaea orientalis PCC 8801]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-404 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 660.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDwTLATGQGILTVKA-NGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNE-------EVLASGLVE-RIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EGKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:PRK00180  73 DGKLGLIKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:PRK00180 153 QTMPEEAYLYALPYELYEKyGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTP 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:PRK00180 233 LEGLVMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKY 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASL-GGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSP--VNIDISTPDSTVRILVIHTQEDWAIA 395
Cdd:PRK00180 313 IGSYAAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARfgKEGDISTPDSKVKVLVIPTNEELMIA 392


                 ....*....
gi 218169099 396 QECCHWLNK 404
Cdd:PRK00180 393 RDTLRLLGK 401
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-404 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 660.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDwTLATGQGILTVKA-NGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNE-------EVLASGLVE-RIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EGKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:PRK00180  73 DGKLGLIKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:PRK00180 153 QTMPEEAYLYALPYELYEKyGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTP 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:PRK00180 233 LEGLVMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKY 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASL-GGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSP--VNIDISTPDSTVRILVIHTQEDWAIA 395
Cdd:PRK00180 313 IGSYAAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARfgKEGDISTPDSKVKVLVIPTNEELMIA 392


                 ....*....
gi 218169099 396 QECCHWLNK 404
Cdd:PRK00180 393 RDTLRLLGK 401
AckA COG0282
Acetate kinase [Energy production and conversion];
1-403 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 640.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDWtLATGQGILTVK-ANGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSE-------EVLAKGLVER-IGLPGARLKHKdAGGEKVERELPIPDHAAALALVLELLT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EGKTkvIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:COG0282   73 DHGI--IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:COG0282  151 QTMPEVAYLYALPYELYEKyGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:COG0282  231 LEGLVMGTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKY 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNIDISTPDSTVRILVIHTQEDWAIAQEC 398
Cdd:COG0282  311 IGAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDT 390


                 ....*
gi 218169099 399 CHWLN 403
Cdd:COG0282  391 LRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-400 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 564.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   3 ILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDWtLATGQGILTVKANGI-KQKITLNSDDHHHGIAKMLGTLVEG 81
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTE-------EVLASGLVER-IGLEGARLKHKVNNGeKIKEELPIPDHEEALKAILDTLTDP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  82 KTKViqHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFHSQ 161
Cdd:cd24010   73 ELGV--SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 162 MPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTPLE 240
Cdd:cd24010  151 MPPHAYLYALPYELYEKyGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 241 GLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQIG 320
Cdd:cd24010  231 GLVMGTRSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIG 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 321 SMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKN-ANSPVNIDISTPDSTVRILVIHTQEDWAIAQECC 399
Cdd:cd24010  311 AYAAALGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNkAAGGGEREISTPDSKVKVLVIPTNEELMIARDTV 390


                 .
gi 218169099 400 H 400
Cdd:cd24010  391 R 391
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-396 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 524.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099    2 KILILNAGSSSQKSCLYDFkeknfldNPVEPIWKADIDWTLATGQGILTVKANGIKQKITLNSDDHHHGIAKMLGTLVeg 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDA-------VIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLL-- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   82 KTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFHSQ 161
Cdd:pfam00871  72 KHKIIELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  162 MPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTPLE 240
Cdd:pfam00871 152 MPEEAYLYALPYSWYKEhGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  241 GLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQIG 320
Cdd:pfam00871 232 GLVMGTRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIG 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218169099  321 SMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNIDISTPDSTVRILVIHTQEDWAIAQ 396
Cdd:pfam00871 312 SYAASLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-401 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099    1 MKILILNAGSSSQKSCLYDFKeknfldNPVEPIWKADIDWTLATGQGILTVKANGIKQKITLNSDDHHHGIAKMLGTLVe 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAV------NGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   81 gKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQ--VLGNIPQVAVFDTAF 158
Cdd:TIGR00016  77 -KDKIIKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  159 HSQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFT 237
Cdd:TIGR00016 156 HQTMPEEAYLYALPYSWYKEhGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  238 PLEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRS 317
Cdd:TIGR00016 236 PLEGLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  318 QIGSMLASLGG-LDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKN--ANSPVNIDISTPDSTVRILVIHTQEDWAI 394
Cdd:TIGR00016 316 YIGSYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNnaARSGKSGVISTPESKVKILVIPTNEELMI 395


                  ....*..
gi 218169099  395 AQECCHW 401
Cdd:TIGR00016 396 AQDAIRL 402
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-404 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 660.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDwTLATGQGILTVKA-NGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNE-------EVLASGLVE-RIGLPDSRIKIKVdGGEKEEEELPIPDHAEALKFLLNTLT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EGKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:PRK00180  73 DGKLGLIKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFH 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:PRK00180 153 QTMPEEAYLYALPYELYEKyGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTP 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:PRK00180 233 LEGLVMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKY 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASL-GGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSP--VNIDISTPDSTVRILVIHTQEDWAIA 395
Cdd:PRK00180 313 IGSYAAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARfgKEGDISTPDSKVKVLVIPTNEELMIA 392


                 ....*....
gi 218169099 396 QECCHWLNK 404
Cdd:PRK00180 393 RDTLRLLGK 401
AckA COG0282
Acetate kinase [Energy production and conversion];
1-403 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 640.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDWtLATGQGILTVK-ANGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSE-------EVLAKGLVER-IGLPGARLKHKdAGGEKVERELPIPDHAAALALVLELLT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EGKTkvIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:COG0282   73 DHGI--IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:COG0282  151 QTMPEVAYLYALPYELYEKyGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:COG0282  231 LEGLVMGTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKY 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNIDISTPDSTVRILVIHTQEDWAIAQEC 398
Cdd:COG0282  311 IGAYAAALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDT 390


                 ....*
gi 218169099 399 CHWLN 403
Cdd:COG0282  391 LRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-400 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 564.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   3 ILILNAGSSSQKSCLYDFKEKnfldnpvEPIWKADIDWtLATGQGILTVKANGI-KQKITLNSDDHHHGIAKMLGTLVEG 81
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTE-------EVLASGLVER-IGLEGARLKHKVNNGeKIKEELPIPDHEEALKAILDTLTDP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  82 KTKViqHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFHSQ 161
Cdd:cd24010   73 ELGV--SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 162 MPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTPLE 240
Cdd:cd24010  151 MPPHAYLYALPYELYEKyGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 241 GLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQIG 320
Cdd:cd24010  231 GLVMGTRSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIG 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 321 SMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKN-ANSPVNIDISTPDSTVRILVIHTQEDWAIAQECC 399
Cdd:cd24010  311 AYAAALGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNkAAGGGEREISTPDSKVKVLVIPTNEELMIARDTV 390


                 .
gi 218169099 400 H 400
Cdd:cd24010  391 R 391
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-396 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 524.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099    2 KILILNAGSSSQKSCLYDFkeknfldNPVEPIWKADIDWTLATGQGILTVKANGIKQKITLNSDDHHHGIAKMLGTLVeg 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDA-------VIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLL-- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   82 KTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFHSQ 161
Cdd:pfam00871  72 KHKIIELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  162 MPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTPLE 240
Cdd:pfam00871 152 MPEEAYLYALPYSWYKEhGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  241 GLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQIG 320
Cdd:pfam00871 232 GLVMGTRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIG 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218169099  321 SMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNIDISTPDSTVRILVIHTQEDWAIAQ 396
Cdd:pfam00871 312 SYAASLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-401 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 520.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099    1 MKILILNAGSSSQKSCLYDFKeknfldNPVEPIWKADIDWTLATGQGILTVKANGIKQKITLNSDDHHHGIAKMLGTLVe 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAV------NGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   81 gKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQ--VLGNIPQVAVFDTAF 158
Cdd:TIGR00016  77 -KDKIIKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  159 HSQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFT 237
Cdd:TIGR00016 156 HQTMPEEAYLYALPYSWYKEhGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  238 PLEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRS 317
Cdd:TIGR00016 236 PLEGLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  318 QIGSMLASLGG-LDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKN--ANSPVNIDISTPDSTVRILVIHTQEDWAI 394
Cdd:TIGR00016 316 YIGSYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNnaARSGKSGVISTPESKVKILVIPTNEELMI 395


                  ....*..
gi 218169099  395 AQECCHW 401
Cdd:TIGR00016 396 AQDAIRL 402
PRK12397 PRK12397
acetate/propionate family kinase;
2-397 4.72e-134

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 389.97  E-value: 4.72e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   2 KILILNAGSSSQKSCLYDFKEKNFL-DNPVEPIWKADidwtlatgqGILTVKANGIKQKITLNSDDHHHGIAKMLGTLVE 80
Cdd:PRK12397   4 KIMAINAGSSSLKFQLLEMPQGDMLcQGLIERIGMAD---------AQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  81 gkTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFHS 160
Cdd:PRK12397  75 --YQIINSLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 161 QMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTPL 239
Cdd:PRK12397 153 TLDEPAYIYPLPWRYYAElGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQ 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 240 EGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQI 319
Cdd:PRK12397 233 SGVMMGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATI 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218169099 320 GSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNidISTPDSTVRILVIHTQEDWAIAQE 397
Cdd:PRK12397 313 GSYIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQRNATF--IQTENALVKVAVINTNEELMIAQD 388
PRK12379 PRK12379
propionate kinase;
3-400 3.49e-123

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 362.13  E-value: 3.49e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   3 ILILNAGSSSQKSCLYDfkeknfldnpvepiwkADIDWTLATG--QGILTVKA----NGIKQkITLNSDDHHHGIAKMLG 76
Cdd:PRK12379   7 VLVINCGSSSIKFSVLD----------------ASDCEVLMSGiaDGINSENAflsvNGGEP-APLAHHSYEGALKAIAF 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  77 TLVEgktkviQHLSD-ISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFD 155
Cdd:PRK12379  70 ELEK------RNLNDsVALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFD 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 156 TAFHSQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTM 234
Cdd:PRK12379 144 TSFHQTLAPEAYLYGLPWEYYEElGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSM 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 235 GFTPLEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHR 314
Cdd:PRK12379 224 GMTPLEGLMMGTRSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHR 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 315 LRSQIGSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNA--NSPVNIDISTPDSTVRILVIHTQEDW 392
Cdd:PRK12379 304 IARHIAGHAASLHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNqpNSGGERIISSENSRVICAVIPTNEEK 383


                 ....*...
gi 218169099 393 AIAQECCH 400
Cdd:PRK12379 384 MIALDAIH 391
PRK07157 PRK07157
acetate kinase; Provisional
 1-397 1.76e-117

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 347.50  E-value: 1.76e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   1 MKILILNAGSSSQKSCLYDFKEKNFLDNP-VEPIWKADidwtlatgqGILTVKANGIKQKITLNSDDHHHGIAKMLGTLV 79
Cdd:PRK07157   3 AKILVINAGSSSIKWQLFDKENLNLIASGlAERIGLEN---------GLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 EgkTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:PRK07157  74 E--NKLIEDLEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFH 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYEWLDK-GIRRYGFHGTSHKYCAEKASQLLNKplTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:PRK07157 152 TSIPKINYTYPINYEIAKKyGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:PRK07157 230 LAGVMMGTRSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDY 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASLGG-LDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNID----ISTPDSTVRILVIHTQEDWA 393
Cdd:PRK07157 310 LANYINKIGKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGEYGpielISTPDSDIPVYVIRTNEELL 389


                 ....
gi 218169099 394 IAQE 397
Cdd:PRK07157 390 IAKN 393
PRK12440 PRK12440
acetate/propionate family kinase;
3-397 4.39e-106

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 318.34  E-value: 4.39e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   3 ILILNAGSSSQKSCLYDFKEKNFLDNPVEPIW---KADIDWtlatgqgiltvKANGIKQKITLNSDDHHHGIAkmLGTLV 79
Cdd:PRK12440   6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFgleDARMSW-----------KYQGEKTEIAIEGEDNHHKIA--IGRLV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  80 eGKTKVIQHLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFDTAFH 159
Cdd:PRK12440  73 -GLTEELGFTQDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFH 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 160 SQMPLEASVYPIPYE-WLDKGIRRYGFHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMGFTP 238
Cdd:PRK12440 152 QTMPKKAFTGAIAKElYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTP 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 239 LEGLMMGTRSGSIDPAILIYLMREyDFTFEQLNEMLNQESGLKGVSGISADLRAIFEAINQGNDRAQLALDMYLHRLRSQ 318
Cdd:PRK12440 232 LSGLMMGTRCGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKY 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 319 IGSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNID--ISTPDS-TVRILVIHTQEDWAIA 395
Cdd:PRK12440 311 IASYLAALDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAgiIAKSELlNAVAMVIPTNEEFVIA 390


                 ..
gi 218169099 396 QE 397
Cdd:PRK12440 391 QQ 392
PRK07058 PRK07058
acetate/propionate family kinase;
3-403 5.11e-102

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 308.13  E-value: 5.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   3 ILILNAGSSSQKSCLYDFKEknfldNPVEPIWKADIDWT-------LATGQGILTVKangIKQKITlnsDDHHHGIAKML 75
Cdd:PRK07058   6 LLTFNAGSSTVKIGLFEVDG-----NEARRIGKGDIDFRraplrfhLRNGGETLDIP---LKASVT---DDLHTVLDETF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  76 GTLVEGKTkviqhLSDISIVGHRVVHGGTDYSEATLITPDVKATIARLIPLAPTHNPSHLEGIEAIEQVLGNIPQVAVFD 155
Cdd:PRK07058  75 DWLAAHFD-----VSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFD 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 156 TAFHSQMPLEASVYPIPYEWLDKGIRRYGFHGTSHKYCAEKASQlLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMG 235
Cdd:PRK07058 150 TAFHRTQPDLVRRFAIPRALHDEGIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 236 FTPLEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISADLRAIfeainQGNDR--AQLALDMYLH 313
Cdd:PRK07058 229 FSTLDGIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDL-----LASDApeAREALDLFAL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 314 RLRSQIGSMLASLGGLDALIFTAGIGENAAIVREKACQGFSFLGLKLDLEKNANSPVNidISTPDSTVRILVIHTQEDWA 393
Cdd:PRK07058 304 RIAGEIARLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAFT--ISSRTSRVAAFVIPTDEEQV 381

                        410
                 ....*....|
gi 218169099 394 IAQECCHWLN 403
Cdd:PRK07058 382 IADEAFSVLR 391
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 2-347 1.70e-30

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 119.56  E-value: 1.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099   2 KILILNAGSSSQKSCLYD----FKEKNFLDNPVEPIWKADIdwtlaTGQgiLTVKANGIKQKItlnsddHHHGIakmlgt 77
Cdd:cd24011    1 RILVINPGSTSTKIAVFEgeeeVFEETIEHSPEELAKFPSI-----IDQ--LEFRKEAVLDFL------KENGI------ 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099  78 lvegktkviqHLSDIS-IVGH----RVVHGGTdYseatLITPDVKATIarLIPLAPTHnPSHLEGIEAIE-QVLGNIPQV 151
Cdd:cd24011   62 ----------DLSDLDaIVGRggllKPIPGGT-Y----RVNEAMLEDL--LSGPLGEH-ASNLGAPIAYElAKEYGIPAY 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 152 AVfDTAFHSQMPLEASVYPIPyewldkGIRRYG-FHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISI 230
Cdd:cd24011  124 IV-DPVVVDEMDPVARITGIP------EIERRSiFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVI 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 231 DTTMGFtPLEGLMMGTRSGSIDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGISaDLRAIFEAINQGNDRAQLALDM 310
Cdd:cd24011  197 DVNNAL-DGEGPFSPERAGTLPVGDLIKLCFSGKYTLEELKKKLKGKGGLVAYLGTN-DFREVEKRIEAGDEKAKLVLDA 274

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 218169099 311 YLHRLRSQIGSMLASLGG-LDALIFTAGIGENAAIVRE 347
Cdd:cd24011  275 MAYQIAKEIGALAAVLKGkVDAIILTGGLAYSKRLVDR 312
PRK03011 PRK03011
butyrate kinase; Provisional
 178-345 1.06e-22

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 98.31  E-value: 1.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 178 KGIRRYG-FHGTSHKYCAEKASQLLNKPLTHLKLITCHLGNGCSLAAIKNGISIDTTMG------FTPLeglmmgtRSGS 250
Cdd:PRK03011 145 PEIERKSiFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSPE-------RAGG 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218169099 251 IDPAILIYLMREYDFTFEQLNEMLNQESGLKGVSGiSADLRAIFEAINQGNDRAQLALDMYLHRLRSQIGSMLASLGG-L 329
Cdd:PRK03011 218 LPVGDLVELCFSGKYTKEELKKKLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkV 296

                        170
                 ....*....|....*.
gi 218169099 330 DALIFTAGIGENAAIV 345
Cdd:PRK03011 297 DAIVLTGGLAYSKRLV 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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