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Conserved domains on  [gi|21759433|sp|Q16842|]
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RecName: Full=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Short=Alpha 2,3-ST 2; Short=Beta-galactoside alpha-2,3-sialyltransferase 2; AltName: Full=Gal-NAc6S; AltName: Full=Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; AltName: Full=Monosialoganglioside sialyltransferase; AltName: Full=ST3Gal II; Short=ST3GalII; AltName: Full=ST3GalA.2; AltName: Full=Sialyltransferase 4B; Short=SIAT4-B

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467707  Cd Length: 279  Bit Score: 612.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433  70 CACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQC 149
Cdd:cd23979   1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 150 RRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIAS 229
Cdd:cd23979  81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979 161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21759433 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979 241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
 
Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 612.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433  70 CACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQC 149
Cdd:cd23979   1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 150 RRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIAS 229
Cdd:cd23979  81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979 161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21759433 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979 241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-341 2.17e-95

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.11  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433    96 VWTRENMDLPPDV--QRWWMMLQpqfkshNTNEVLEKLFQIVPgenpyrfRDPHQCRRCAVVGNSGNLRGSGYGQDVDGH 173
Cdd:pfam00777   1 FLTKENFPLGEWIrySEWWLPFT------VTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433   174 NFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKN-----------LPANVSFVLVPFKVLDLLWIASALSTGQIR----- 237
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDskygnlgfshpRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSrslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433   238 -FTYAPVKSflRVDKEKVQIYNPAFFKYIHDRWTEHHG---RYPSTGMLVLFFALHVCDEVNVYGFGA--DSRGNWHHYW 311
Cdd:pfam00777 148 lYTLKEVKI--PVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 21759433   312 ENNRYAGeFRKTGVHDADFEAHIIDMLAKA 341
Cdd:pfam00777 226 DNVLMKK-GGFYGVHDMPFEFKLLQKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 612.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433  70 CACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQC 149
Cdd:cd23979   1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 150 RRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIAS 229
Cdd:cd23979  81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979 161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21759433 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979 241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 72-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 534.94  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433  72 CRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPqFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRR 151
Cdd:cd23966   1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQS-SKNSDLREVLEKLFQVVPGENPYRTRDPNRCRR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 152 CAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASAL 231
Cdd:cd23966  80 CAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 232 STGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYW 311
Cdd:cd23966 160 TTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHYW 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21759433 312 ENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23966 240 EKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 70-348 3.03e-139

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 396.17  E-value: 3.03e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433  70 CACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGE-NPYRFRDPHQ 148
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNvDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIA 228
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 229 SALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 308
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 21759433 309 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-341 2.17e-95

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.11  E-value: 2.17e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433    96 VWTRENMDLPPDV--QRWWMMLQpqfkshNTNEVLEKLFQIVPgenpyrfRDPHQCRRCAVVGNSGNLRGSGYGQDVDGH 173
Cdd:pfam00777   1 FLTKENFPLGEWIrySEWWLPFT------VTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433   174 NFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKN-----------LPANVSFVLVPFKVLDLLWIASALSTGQIR----- 237
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDskygnlgfshpRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSrslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433   238 -FTYAPVKSflRVDKEKVQIYNPAFFKYIHDRWTEHHG---RYPSTGMLVLFFALHVCDEVNVYGFGA--DSRGNWHHYW 311
Cdd:pfam00777 148 lYTLKEVKI--PVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 21759433   312 ENNRYAGeFRKTGVHDADFEAHIIDMLAKA 341
Cdd:pfam00777 226 DNVLMKK-GGFYGVHDMPFEFKLLQKLHKE 254
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 126-348 3.67e-51

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 171.67  E-value: 3.67e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 126 EVLEKLFQIVPG-ENPYRF--RDPHQ-CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMY 201
Cdd:cd23964  55 EVVERLLRNLNLtSSRYMFvlRGGRPrCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFF 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 202 PESAKN-----LPA--NVSFVLVPFKVLDLLWIASALS-----TGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRW 269
Cdd:cd23964 135 PESLHNsllkhVPQdkDTKYLFIPFKIRDYDYLDAVLSgkpvpDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRW 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 270 TEHH-GRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYweNNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23964 215 LNSStSYRPTTGALMLLTALHTCDQVSVYGFGYDPRFSLHYY--DKTFVKFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 152-338 3.38e-49

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 163.69  E-value: 3.38e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 152 CAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANV--SFVLVPFKVLDLLWIas 229
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPrcGCHPLPLEEEVVLIL-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 230 alSTGQIRFTYAPVKSFLRVDKEKVQIYNPA--FFKYIHDRWTEHH------GRYPSTGMLVLFFALHVCDEVNVYGFGA 301
Cdd:cd19952  79 --SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGV 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 21759433 302 DS---RGNWHHYWENNRYAgefRKTGVHDADFEAHIIDML 338
Cdd:cd19952 157 DSghaPKVPYHYYDLVEAE---EGTAVHSFDLEAELLRAL 193
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 149-335 1.96e-47

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 159.38  E-value: 1.96e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPA----NVSFVLVPFKVLDL 224
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEeydsDWLLVLVPFKSMDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 225 LWIASALS----TGQIRFTYAPVKSFlRVDKEKVQIYNPaffkYIHDRWTEHHGRY----------PSTGMLVLFFALHV 290
Cdd:cd23967  82 LWLQAVIKgkkpNGKGGFWKKIATSV-PKPPKKIRILNP----YILQEAAFDLIGLpmngkqgknvPTTGIIAIVMALHY 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21759433 291 CDEVNVYGFGAD-SRGN-WHHYWENNRYAGEFRKTGvHDADFEAHII 335
Cdd:cd23967 157 CDEVDIAGFGYDpSDPNaPLHYYDSLTMKAIKRSWT-HNVTKEKKYL 202
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 149-313 3.07e-46

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 156.36  E-value: 3.07e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKVLD 223
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgiendPDTLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 224 LLWIASALSTGQI--RFTYAPVKSFLRVDKEKVQIYNPAF-----FKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNV 296
Cdd:cd23982  82 FYWLYEILSNEKRvrKGFWKQPPRIWDANPKQIRILNPYYtyvaaTKLLQVPGQRKKKQKPTTGLLAITLALHLCDEVHI 161

                       170       180
                ....*....|....*....|
gi 21759433 297 YGFGADSRGN---WHHYWEN 313
Cdd:cd23982 162 AGFGYPDNGNsnqPIHYYNQ 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 149-331 5.17e-33

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 121.77  E-value: 5.17e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESA----KNLPANVSFVLVPFKVLDL 224
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGApkseQEYDPTSLFVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 225 LWIASALSTGQIR-----FTYAPVKSFLRVDKEKVQIYNPAFFKYI----------HDRWTEHHGRYPSTGMLVLFFALH 289
Cdd:cd23983  82 AWLKAMVKKEPLSfwsrlFFWKEVADSIPLKPSQFRILNPLIIKETaldilqypepQSRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 21759433 290 VCDEVNVYGFGAD--SRGNWHHYWENNRYAGEFRKTgVHDADFE 331
Cdd:cd23983 162 LCDEVSLAGFGYDlsQPHAPLHYYDSVCMAAMNTQT-MHNVTKE 204
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 129-327 5.98e-33

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 123.53  E-value: 5.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 129 EKLFQIVPGENPyrFRDPHQcRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNL 208
Cdd:cd23963  46 KSLYELLPKTSP--FSHKRY-KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRR 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 209 ------PANVSFVLVPFKVLD--LLWIASALSTGQIRFTYApVKSFLRVDKEKVQI--YNPAFFKYIHDRWTEHHG-RYP 277
Cdd:cd23963 123 ynslkkNRDRDKFLNRLKEYNgsILWYPKFSFKSSTNLLLK-AARALKKNGLNLTVvySNPEHFLAVQKFWKRRGLeKRP 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21759433 278 STGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWENNRYAGefrKTGVHD 327
Cdd:cd23963 202 STGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPvpYHYYDDLSPST---KNKVHN 253
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 149-313 4.71e-31

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 116.38  E-value: 4.71e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLP----ANVSFVLVPFKVLDL 224
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPshydPNTTVVLIPFKPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 225 LWIASALSTGQIR---FTYAPVKSfLRVDKEKVQIYNPAFFKYIHDRW--------TEHHGRYPSTGMLVLFFALHVCDE 293
Cdd:cd23984  82 RWLLDLLMGKKVSakgFWKKPALN-LIYKPNQIRILNPFILRIAAYELlhfpkrfpKEKKPKHPTTGIIAITLALHICNE 160

                       170       180
                ....*....|....*....|..
gi 21759433 294 VNVYGFGAD--SRGNWHHYWEN 313
Cdd:cd23984 161 VHIAGFKYDfsNLNSTLHYYGN 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 149-347 4.87e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 108.30  E-value: 4.87e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPAN--------------VSF 214
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngppqskeTRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 215 VLVPFKVLDLLWIASALSTGQIR----FTYAPVKSF-LRVDKEKVQIYNPAFFKYIHDRW-------TEHHGRY-PSTGM 281
Cdd:cd23974 164 IFLPDHDRDYLLVKAALTHTPIDrgrdKSKRPSKYFgKDVTAEKFKIYHPDFIRYLRNRFlwspilnTKQRDIYrPSTGA 243

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21759433 282 LVLFFALHVCDEVNVYGFGADSRGNWH-HYWENNRYAGEFRKTgvHDADFEAHIIDMLAKASKIEVY 347
Cdd:cd23974 244 VMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKTYHKVVFYAN--HDLRLEMQLWQKLHKAGLIKLY 308
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 149-317 5.06e-27

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 105.77  E-value: 5.06e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVS----FVLVPFKVLDL 224
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslFVLAGFKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 225 LWIASALSTGQIRFTYAPVKSF-LRVDKE--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALHVCDE 293
Cdd:cd23981  82 KWLKYIVYKEKVSASDGFWKSVaTRVPREphEIRILNPYFiqeaaFSFIglpFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                       170       180
                ....*....|....*....|....*.
gi 21759433 294 VNVYGFGADSRGNWH--HYWENNRYA 317
Cdd:cd23981 162 VAVAGFGYDMNTPNAplHYYETIKMS 187
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 141-348 1.09e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 107.60  E-value: 1.09e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 141 YRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKN------------L 208
Cdd:cd23972  74 FPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNslisywnlgftrT 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 209 P--ANVSFVLVPFKVLDLLWIASALSTGQIRFTY----APVKSF-LRVDKEKVQIYNPAFFKYIHDRW-------TEHHG 274
Cdd:cd23972 154 PqgQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLdkgdRPHKYFgPEASAKKFKLLHPDFISYLTDRFlkskllnTHYGH 233

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759433 275 RY-PSTGMLVLFFALHVCDEVNVYGF-GADSRGNWHHYWENNRYAGEFRKTgvHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23972 234 LYmPSTGALMLLTALHTCDQVSAYGFiTSNYWKFSDHYYERKKKPLVFYAN--HDMLLEAALWRRLHKAGILQLYQ 307
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 150-348 1.51e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 106.20  E-value: 1.51e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 150 RRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTT----HHFMYPESAKNLPANVSFVLVPFkvldLL 225
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrliNSQILSKPEFNFLTDPLYRNVTL----LV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 226 WIASALSTGQIRFTYAPVKSF--------LRVDKEKVQIYNPAFFKYIHD---RWTEH--HGRYPSTGMLVLFFALHVCD 292
Cdd:cd23968 122 WDPSSYNVNLEKWYKKPDFDFfpnyikyrRRHPEEPFYLIDPRFLWRLWDilqEYTPEkiKPNPPSSGFIGIVLMLHLCD 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21759433 293 EVNVYGFGADSRGNWH-HYWENnrYAGEFRKTG-VHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23968 202 WVDVYEYVPSVRQTDRcHYYDV--EKDLACTLGaWHPLAAEKLLVRHLNVGSDDDIFR 257
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 147-349 4.06e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 103.29  E-value: 4.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 147 HQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTThhfMYPESA---------------KNLPAN 211
Cdd:cd23973  81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAhsitsslmilqkrgfKNIPQD 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 212 --VSFVLVPFKVLDLLWIASALSTGQIR----FTYAPVKSF-LRVDKEKVQIYNPAFFKYIHDRW-------TEHHGRY- 276
Cdd:cd23973 158 kdIKYILFPEGPRDYQWLEALLKNKTIPsgayYGRRPRSYFsGDFTEDKYLVLHPDFLRYVKNRFlrsktlkGKYWAIYr 237

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21759433 277 PSTGMLVLFFALHVCDEVNVYGF-GADSRGNWHHYWENNRYAGEFrkTGVHDADFEAHIIDMLAKASKIEVYRG 349
Cdd:cd23973 238 PTTGAFLLLTALHLCDTVSAYGFiTEDYRKYPDHYYDKKKTKLVF--YINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 119-322 9.66e-24

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 98.64  E-value: 9.66e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 119 FKSHNTNEVLEKLFQIVPGENPyrFRDPHqCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHH 198
Cdd:cd23969  37 IDRHKTVNITQDLYQLLPEVSP--LKGKH-FRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 199 FMYPesaknlpanvSFVLVPFKVLD------------------LLWIASALSTG---QIRFTYAPVKsflrvdKEKVQI- 256
Cdd:cd23969 114 TMNP----------SVIPHAYGDLVnatdkekfverlrqlgdsILWIPAFVSKGgeeHVQWTNEIIL------KHKLNVk 177

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759433 257 --YNPA-FFKYIHDRW--TEHHGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRYAGEFRK 322
Cdd:cd23969 178 taYPPLrLNHAIRGYWltTKFRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavKYHYYDNRKYLTTARP 253
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 124-338 9.19e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 93.48  E-value: 9.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 124 TNEVLEKLFQIVPGENPYRFRdphQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPE 203
Cdd:cd23988  42 TLNISQNLHSLLPEVSPMKNR---RFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPS 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 204 -------SAKNLPANVSFVLVPFKVLD-LLWIASALSTGQIRFTyAPVKSFLRVDKEKVQIYNPAfFKYIH---DRWTEH 272
Cdd:cd23988 119 vvqrafgGFRNESDREKFVHRLSMLNDsVLWIPAFMVKGGEKHV-EWVNALILKNKLKVRTAYPS-LRLIHavrGYWLTN 196

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21759433 273 --HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRYAgEFRKTGVHDADFEAHIIDML 338
Cdd:cd23988 197 kvNIKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNpvKYHYYDDLKYR-YFSNAGPHRMPLEFKTLNVL 268
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 149-316 1.57e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 91.54  E-value: 1.57e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVL--VPFKVLDLLW 226
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLagTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 227 IASALSTGQIRFTYAPVKSFLRVDKEkVQIYNPAFFKYIH-DRWTEHH--------GRYPSTGMLVLFFALHVCDEVNVY 297
Cdd:cd23965  81 GPETKMNKDGAGKYNLLRSLSKKYPD-VEFYSLTPEKMDYaDELFEKEtgksriksGTWLSTGWFTMLLALDVCDEIKVY 159

                       170       180
                ....*....|....*....|....*.
gi 21759433 298 GFGADS--RGNWH-----HYWENNRY 316
Cdd:cd23965 160 GMVPENycREHPNskvpyHYYEPGGL 185
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 127-327 1.09e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 90.01  E-value: 1.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 127 VLEKLFQIVPGENPYRfrdPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPtVGFEQDVGSRTT---------- 196
Cdd:cd23971  45 VNEKLFSMLPKESPFS---NKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNlvtanpsilr 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 197 ---HHFMYP-----ESAKNLPAnvSFVLVPfkvldllwiasALSTGQ-----IRFTYApVKSFLRvdKEKVQIYNPAFFK 263
Cdd:cd23971 121 ekfHNLKKRrrpfvERMKVYGN--ALLLLP-----------AFSYTSntepsLRALYT-LEDFGS--PQKVLFFNPEYLR 184

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21759433 264 YIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWENNRyagefRKTGVHD 327
Cdd:cd23971 185 NLSRYWKSKglKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPisHHYYDNVL-----PKKGVHA 250
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 119-313 6.94e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 85.27  E-value: 6.94e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 119 FKSHNTNEVLEKLFqivPGENPYRFRdphqCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAP-TVGFEQDVGSRTth 197
Cdd:cd23989  40 LHSHTVDNETYSLF---PQDTPLQLP----LKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 198 hfmypesaKNLPANVSFVLVPFKvlDLLWIASA----LSTGQIRFTYAPVKSF-------LRV--------DKEKVQIYN 258
Cdd:cd23989 111 --------QLVTANPSIIDKRFQ--NLLWSRKSfvesMKVYGRSYIYMPAFSMktgtdpsLRVyytladvgANQTVLFAN 180

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21759433 259 PAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF-----GADSRGNWHHYWEN 313
Cdd:cd23989 181 PNFLRNVGKFWKSKgvHAKRLSTGLFLVSAALGLCEEVTIYGFwpfsvDLDERTISHHYYDN 242
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 149-315 1.32e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 83.37  E-value: 1.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTT----HHFMYPESAKNLP------ANVSFVLV- 217
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSlrvvSHTSVPLLLRNQGyffqqsRDTKYVIWg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 218 PFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQiYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVY 297
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMA-YCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVY 159

                       170       180
                ....*....|....*....|....*
gi 21759433 298 GFGADS--RGNWH-----HYWENNR 315
Cdd:cd23977 160 GMVSDSycRNKNHssvpyHYYEKGR 184
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 107-330 5.67e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 82.83  E-value: 5.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 107 DVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPyrFRDPHQcRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVG 186
Cdd:cd23970  29 DVRIGQLMHFDYSSHKYVFSISPNLRSLLPEVSP--FQNKHY-NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 187 FEQDVGSRTTHHFMYPESAKNLPANVSFV------LVPFKVLD--LLWIASALSTGQIRFTYAPVKSFLRV-DKEKVQIY 257
Cdd:cd23970 106 FEKDVGRKTNLTTFNPSILEKYYNNLLTIqdrnnfFLSLKKLDgaILWIPAFFFHTSATVTRTLVDFFVEHrGQLKVQLA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 258 NPA-FFKYIHDRWTEHHG--RYPSTGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWEN--NRYAGEFRKTGVHD 327
Cdd:cd23970 186 WPGnIMQHVNRYWKTKHLspKRLSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPlpYHYYDKkgTKFTTKWQESHQLP 265


                ...
gi 21759433 328 ADF 330
Cdd:cd23970 266 AEF 268
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 129-313 3.81e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 80.18  E-value: 3.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 129 EKLFQIVPGENPyrFRDPhQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVG-FEQDVGSRTTHHFMYPESAKN 207
Cdd:cd23991  47 ENIFRMFPKSQP--FRGY-PYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISI 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 208 LPANVSFVLVPF--------KVLDLLWIASALSTGQIRF-TYAPVKSFlrVDKEKVQIYNPAFFKYIHDRWTEHHGRYP- 277
Cdd:cd23991 124 KYAKLNERRKPFletvsvygDAFLLLPAFSYRSNTALSFkVYYTLEDF--KAKQKVIFFHPIYLKHLAQFWRSKGVQVYr 201

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 21759433 278 -STGMLVLFFALHVCDEVNVYGFGADSRGN-----WHHYWEN 313
Cdd:cd23991 202 lSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDN 243
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 119-316 3.41e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 77.67  E-value: 3.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 119 FKSHNTNEVLEKLFQIVPGENPYRFRdphQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHH 198
Cdd:cd23987  37 FDRDSTMNISQNLYELLPRTSPLKNK---HFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 199 FMYP---ESAKNLPANVSFV---LVPFKVLD--LLWIASALST-GQIRFTYapVKSFLRVDKEKVQIYNPA--FFKYIHD 267
Cdd:cd23987 114 TMNPsvvQRAFEDLVNETWKekfLQRLQSLNgsILWIPAFMAKgGEERVEW--VNDLILKHHINVRTAYPSlrLLHAVRG 191

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21759433 268 RW-TEH-HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRY 316
Cdd:cd23987 192 YWlTNKvHIKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNpvKYHYYDSLKY 247
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 148-299 5.12e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.05  E-value: 5.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 148 QCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMypesaknlpaNVSFVLVPfkvlDLLWI 227
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI----------NSQLVTTE----KHKFL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 228 ASALSTGQIRFTYAPV-------KSFLRVDK---EKVQIY---NPAFFKYI---HDRWT----------EHHGRY-PSTG 280
Cdd:cd23985 110 KDSLYNEGILIVWDPApyhsdipEWYKNPDYnffENYKTYrrlNPNQPFYIlhpQMQWElwdiiqenspEEIQPNpPSSG 189

                       170
                ....*....|....*....
gi 21759433 281 MLVLFFALHVCDEVNVYGF 299
Cdd:cd23985 190 MLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 149-316 7.60e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 72.66  E-value: 7.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTT----HHFMYPESAKNlP------ANVSFVLV- 217
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTirvvSHTSVPLLLKN-PdyffkeTNETIYVIw 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 218 -PFK---------VLDLL-WIASALSTGQIRFTyapvksflrvdKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFF 286
Cdd:cd23975  80 gPFRnmrkdgkgiVYNMLkKAVESYPQAKIYVT-----------TEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLIL 148

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21759433 287 ALHVCDEVNVYGFGADS-------RGNWHHYWENNRY 316
Cdd:cd23975 149 AMDACYGIHVYGMINDTycktegyRKVPYHYYEPGRD 185
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 129-348 1.64e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.56  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 129 EKLFQIVPGENPYrfrdPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTT------------ 196
Cdd:cd23986  33 EKYVPKIPLSKLH----LRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnp 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 197 -HHFMYPESAKNLPAnVSFVLVPFKVLDLLWIASA---LSTGQIRFTyapvksfLRVDKEKVQIYNPAFFKYIHDRWTEH 272
Cdd:cd23986 109 nHHFIDSSLYKDVIL-VAWDPAPYSANLHKWYKKPdynLFTPYVQYR-------KRNPNQPFYILHPKFIWQLWDIIQEN 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 273 HGRY-----PSTGMLVLFFALHVCDEVNVYGFGADSR-GNWHHYWEnnRYAGEFRKTGV-HDADFEAHIIDMLAKASKIE 345
Cdd:cd23986 181 TQEKiqpnpPSSGFIGILIMMSMCREVHVYEYIPSVRqTDLCHYHE--RYYDAACTLGAyHPLLYEKLLIQRMNKGTEDD 258


                ...
gi 21759433 346 VYR 348
Cdd:cd23986 259 LYR 261
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 129-313 7.02e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 64.86  E-value: 7.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 129 EKLFQIVPGENPYRfrdPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAP-TVGFEQDVGSRTTHHFMYPESAKN 207
Cdd:cd23990  47 SEIFKMFPKDMPYS---RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITE 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 208 LPANVSFVLVPF-KVLDLLWIASAL---------STGQIRFTYApVKSFlrVDKEKVQIYNPAFFKYIHDRWTEH--HGR 275
Cdd:cd23990 124 RFHKLEKWRRPFyEVLQVYENASVVlpafyntrnTDVSIRVKYV-LDDF--ESQQAVYYFHPQYLLNVSRFWLRQgvRAK 200

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 21759433 276 YPSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 313
Cdd:cd23990 201 RISSGLMLVTAALELCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-298 1.33e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 148 QCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLvpfkvldllwi 227
Cdd:cd23976  14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELL----------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 228 asALSTGQIRFTYAPvKSFLRVDKeKVQIYN---------PAFFKYIHDR---------WTEHHGR-------YPSTGML 282
Cdd:cd23976  83 --NVSQGTVFIFWGP-SNYMRRDG-KGLVYNnlqlmnqilPKLKVYTITRhkmlqfdelFKRETGKdrkisntWLSTGWF 158

                       170
                ....*....|....*.
gi 21759433 283 VLFFALHVCDEVNVYG 298
Cdd:cd23976 159 TMIIALELCDRINVYG 174
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 149-298 1.73e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 1.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 149 CRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTT-----HHFMY-----PESAKNLPANVSFVL-- 216
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTPETTLIFwg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759433 217 ------VPFKVLDLLWIASALSTGqirftyaPVKSFLRVDKEKVQIYNPAFFKYI-HDRWTEHhgRYPSTGMLVLFFALH 289
Cdd:cd23978  81 ppnkmqKDGKSNLFRIIQRASMTF-------PNMSAFVVSPRRMRQFDDLFRGETgRDRKKSH--SWLSTGWFTMVIAVE 151


                ....*....
gi 21759433 290 VCDEVNVYG 298
Cdd:cd23978 152 LCDNVHVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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