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Conserved domains on  [gi|21754914|dbj|BAC04591|]
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unnamed protein product [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-225 7.12e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914  63 KPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC--EECGKAFSIFS 134
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914 135 T-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLIKHKLIHTGDKPY 205
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|
gi 21754914 206 KCEACGKaFRRSSHLSRHKI 225
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 5-85 2.07e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914   5 GEKPYKCE--ECGKAFNRSSHLTTHKRihTGHKPYKCKECGKSfsvfstlTKHKIIHTDKKPYKCEECGKAFNRSSILSI 82
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 21754914  83 HKK 85
Cdd:COG5189 417 HRK 419
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-225 7.12e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914  63 KPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC--EECGKAFSIFS 134
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914 135 T-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLIKHKLIHTGDKPY 205
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|
gi 21754914 206 KCEACGKaFRRSSHLSRHKI 225
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 5-85 2.07e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914   5 GEKPYKCE--ECGKAFNRSSHLTTHKRihTGHKPYKCKECGKSfsvfstlTKHKIIHTDKKPYKCEECGKAFNRSSILSI 82
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 21754914  83 HKK 85
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
23-47 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*
gi 21754914    23 HLTTHKRIHTGHKPYKCKECGKSFS 47
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
80-104 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*
gi 21754914    80 LSIHKKIHTGEKPYKCEECGKAFKR 104
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-225 7.12e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914  63 KPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC--EECGKAFSIFS 134
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914 135 T-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLIKHKLIHTGDKPY 205
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|
gi 21754914 206 KCEACGKaFRRSSHLSRHKI 225
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
7-168 1.03e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 1.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914   7 KPYKCEECGKAFNRSSHLTTHKR--IHTG--HKPYKCKE--CGKSFSVFSTLTKHKIIHTDKKPYKC--EECGKAFNRSS 78
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914  79 I-----LSIHKKIHTGEKPYKCE--ECGKAFKRSSHLAGHKQIHSVQKP--YKCEECGKAFSIFSTLTKHKIIHTEEKPY 149
Cdd:COG5048 368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*....
gi 21754914 150 KCEKCGKTFYRFSNLNTHK 168
Cdd:COG5048 448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 89-168 1.88e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 1.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914  89 GEKPYKCE--ECGKAFKRSSHLAGHKqIHSVQKPYKCEECGKafsifstlTKHKIIHTEEKPYKCEKCGKtfyRFSNLNT 166
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDK---RYKNLNG 413


                ..
gi 21754914 167 HK 168
Cdd:COG5189 414 LK 415
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 5-85 2.07e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914   5 GEKPYKCE--ECGKAFNRSSHLTTHKRihTGHKPYKCKECGKSfsvfstlTKHKIIHTDKKPYKCEECGKAFNRSSILSI 82
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 21754914  83 HKK 85
Cdd:COG5189 417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
7-60 2.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.09e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21754914   7 KPYKCEECGKAFNRSSHLTTHKRIHTGHKPYKC--KECGKSFSVFSTLTKHKIIHT 60
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-131 7.42e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 7.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914   1 MIHTGE--KPYKCEE--CGKAFNRSSHLTTHKRIHTGHKPYKCK--ECGKSFSVFST------LTKHKIIHTDKKPYKCE 68
Cdd:COG5048 312 VNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLS 391

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21754914  69 -ECGKAFNRSSILSIHKKIHTGEKP--YKCEECGKAFKRSSHLAGHKQIHSVQKPYKCEECGKAFS 131
Cdd:COG5048 392 nSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 145-224 1.25e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21754914 145 EEKPYKCE--KCGKTFYRFSNLNTHKiihtgekpcKCEECGKAFNHSSNLIKHKLIHTGDKPYKCEACGKAFRRSSHLSR 222
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 21754914 223 HK 224
Cdd:COG5189 417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 61-116 1.79e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 1.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21754914  61 DKKPYKCE--ECGKAFNRSSILSIHKK-------------------IHTGEKPYKCEECGKAFKRSSHLAGHKQiHS 116
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
23-47 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*
gi 21754914    23 HLTTHKRIHTGHKPYKCKECGKSFS 47
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
80-104 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*
gi 21754914    80 LSIHKKIHTGEKPYKCEECGKAFKR 104
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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