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Conserved domains on  [gi|217502434|gb|ACK49843|]
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major facilitator superfamily MFS_1 [Methylocella silvestris BL2]

Protein Classification

TCR/Tet family MFS transporter( domain architecture ID 13024400)

TCR/Tet family major facilitator superfamily (MFS) transporter functions as a metal-tetracycline/H(+) antiporter that confers tetracycline resistance (TCR) by an active tetracycline efflux

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
5-384 1.12e-137

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 398.16  E-value: 1.12e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEDVTR-TQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAI 83
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  84 NYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIA 163
Cdd:cd17388   81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 164 AAVLNACNFLLALFILPESRTPG-RQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWN 242
Cdd:cd17388  161 AAGLNGLNFLLGLFVLPESLPPErRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 243 GFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALA 322
Cdd:cd17388  241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217502434 323 TRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVIYSMAVPLVL 384
Cdd:cd17388  321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAY 382
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
5-384 1.12e-137

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 398.16  E-value: 1.12e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEDVTR-TQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAI 83
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  84 NYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIA 163
Cdd:cd17388   81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 164 AAVLNACNFLLALFILPESRTPG-RQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWN 242
Cdd:cd17388  161 AAGLNGLNFLLGLFVLPESLPPErRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 243 GFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALA 322
Cdd:cd17388  241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217502434 323 TRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVIYSMAVPLVL 384
Cdd:cd17388  321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAY 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-349 2.36e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.18  E-value: 2.36e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAA 82
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGAS---PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  83 INYVLLAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLP 160
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 161 FIAAAVLNACNFLLALFILPESRTPGRQKIdlaalnpLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQ 240
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARL-------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 241 WNGFWIGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQ 319
Cdd:COG2814  240 LSASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQ 318
                        330       340       350
                 ....*....|....*....|....*....|
gi 217502434 320 ALATRQVDEARQGQFQGVLASAVSLASIVA 349
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
8-350 5.42e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.64  E-value: 5.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434    8 IYATIGLDAVGIGLIFPILPRLLEDVTRTQniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVL 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS--PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   88 LAFAPQLWMLLLGRAIAGLT-SANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAA 165
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFLILA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  166 VLNACNFLLALFILPESRTPGRQKIDLAALNPLRPLRwVLSMKGLLPIIFVFFILSATGEAYGVcWALWGFDTFQWNGFW 245
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK-ALLRDPVLWLLLALLLFGFAFFGLLT-YLPLYQEVLGLSALL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  246 IGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG---SIGTPALQALA 322
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGfgfGLVFPALNALV 316
                         330       340
                  ....*....|....*....|....*...
gi 217502434  323 TRQVDEARQGQFQGVLASAVSLASIVAP 350
Cdd:pfam07690 317 SDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
3-207 9.68e-15

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 75.34  E-value: 9.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLED--VTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAG 80
Cdd:PRK09874  14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQlgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  81 AAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLP 160
Cdd:PRK09874  94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRP 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 217502434 161 --FIAAAVLNACnFLLALFILPESRTPGRQKIDLAA---LNPLRPLRWVLSM 207
Cdd:PRK09874 174 vfFITASVLFLC-FLVTLFCIRENFQPVSKKEMLHMrevVTSLKNPKLVLSL 224
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
55-182 1.28e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 56.56  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   55 FIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAgRFGL 133
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAvVLNTEFLPKKQRA-IVGT 219
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 217502434  134 FNAMF-GVGFIIGPVLGGLLGDY-----WLRLPFIAaavlnacnFLLALFILPES 182
Cdd:TIGR00898 220 LIQVFfSLGLVLLPLVAYFIPDWrwlqlAVSLPTFL--------FFLLSWFVPES 266
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
5-384 1.12e-137

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 398.16  E-value: 1.12e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEDVTR-TQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAI 83
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  84 NYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIA 163
Cdd:cd17388   81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 164 AAVLNACNFLLALFILPESRTPG-RQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWN 242
Cdd:cd17388  161 AAGLNGLNFLLGLFVLPESLPPErRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 243 GFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALA 322
Cdd:cd17388  241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217502434 323 TRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVIYSMAVPLVL 384
Cdd:cd17388  321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAY 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
8-386 3.00e-67

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 216.68  E-value: 3.00e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   8 IYATIGLDAVGIGLIFPILPRLLEDVTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVL 87
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  88 LAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLG-DYWLRLPFIAAAV 166
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 167 LNACNFLLALFILPEsrtpgrqkidlaalnplrplrwvlsmkgLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWI 246
Cdd:cd17330  161 LALLNLVLVLFFLPP----------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 247 GLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQ 325
Cdd:cd17330  213 GLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGtGIVFPALSALLSKS 292
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 326 VDEARQGQFQGVLASAVSLASIVAPLAFSTFYfvvQAEWPGAIWLAVVVIysMAVPLVLLG 386
Cdd:cd17330  293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY---SFLGPGVPFLLAAGL--LLIALFLLS 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
8-380 4.29e-44

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 156.97  E-value: 4.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   8 IYATIGLDAVGIGLIFPILPRLLEDVTRTQNIapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVL 87
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQ---IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  88 LAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAA 165
Cdd:cd17325   78 FAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALgYRAPFLVCA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 166 VLNACNFLLALFILPESRTPGRQKIDLAALNPlRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFW 245
Cdd:cd17325  158 ALALLALVLALLLLPEPRPPPNKRAVSAARLR-SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 246 IGLSLGAFGVCQTLVQALLPGPATKlLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATR 324
Cdd:cd17325  237 IGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLALLAD 315
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 325 QVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWP----GAIWLAVVVIYSMAV 380
Cdd:cd17325  316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPflaaAALLLLAAVLFLLLR 375
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
14-351 7.40e-38

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 139.67  E-value: 7.40e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  14 LDAVGIGLIFPILPRLLEDVTRTQNIapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ 93
Cdd:cd17390    7 LDLFGVSMILPLLSTHIRSLGASPTV---IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  94 LWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW--LRLPFIAAAVLNACN 171
Cdd:cd17390   84 LALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCSAIFILN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 172 FLLALFILPESrtpgrqkidlaalnplrplrWVLsmkgllpiIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLG 251
Cdd:cd17390  164 AGLVWFLLSKL--------------------WDL--------LLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLIS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 252 AFGVCQTLVQALLPGPATKLLGERRAVLVGIAC-ACIALVAMAFAKQGWIVFAIMPIFALGS-IGTPALQALATRQVDEA 329
Cdd:cd17390  216 YSGVLGALSGFLVGRILKLYKNNEYLLLLHSFIlLALSLLGLALAPSIWLLVLCLTPLSISSaVLRTCSTSLLLSRGKSK 295
                        330       340
                 ....*....|....*....|..
gi 217502434 330 RQGQFQGVLASAVSLASIVAPL 351
Cdd:cd17390  296 ERGTLLGVGQSVTSLARILAPL 317
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-349 2.36e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.18  E-value: 2.36e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAA 82
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGAS---PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  83 INYVLLAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLP 160
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 161 FIAAAVLNACNFLLALFILPESRTPGRQKIdlaalnpLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQ 240
Cdd:COG2814  167 FLVNAVLALLALLLLLRLLPESRPAARARL-------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 241 WNGFWIGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQ 319
Cdd:COG2814  240 LSASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQ 318
                        330       340       350
                 ....*....|....*....|....*....|
gi 217502434 320 ALATRQVDEARQGQFQGVLASAVSLASIVA 349
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
4-351 2.06e-31

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 122.71  E-value: 2.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   4 PLLVIYATIGLDAVGIGLIFPILPRLLEdvtRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAI 83
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTK---KLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSAL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  84 NYVLLAFAPQLWMLLLGRaIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFI 162
Cdd:cd17331   78 SYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFgEQAAAL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 163 AAAVLNACNFLLALFILPESrtPGRQKIDLAALNP-------LRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWG 235
Cdd:cd17331  157 VAAVGSLLSIVLVILLIPSN--TKSKREKEAKESAsppsvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 236 FDTFQWNGFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIG 314
Cdd:cd17331  235 MDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGgSVL 314
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 217502434 315 TPALQALATRQVDEARQGQFQGVLASAVSLASIVAPL 351
Cdd:cd17331  315 YTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPT 351
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
5-386 1.06e-30

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 121.23  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLE---------------------------DVTRTQNIAPYIGIMIALYGIMQFIF 57
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDyygqnddsglyslqissvdwfrdaigaPDERRYNSVLFGGLIGSLFSLLQFLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  58 APVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAM 137
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 138 FGVGFIIGPVLGGLL-------GDYWLRLPFIAAAVLNACNFLLALFILPESRtpgrqkidlaalnpLRPLRWVlsmkGL 210
Cdd:cd17389  161 FSLGFIIGPMIGAYFasftrslGEVFFSMPALFALVLALADLLFIFFFLPETL--------------PSNLRRL----GL 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 211 LPIIFVFFIlsaTGEAYGVCWALwgFDTFQWNGFWIGLSLGAFGVCQTLVQAllpGPATKL--LGERRAVLVGIACACIA 288
Cdd:cd17389  223 VYFLYLFLF---SGLEFTLTFLT--HQRFQYTSMQQGKMFFFIGIIMALVQG---GYVRRIkpGKEKKAVLQGLILLIPA 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 289 LVAMAFAKQGWIVFAIMPIFALGS-IGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGA 367
Cdd:cd17389  295 FLLIGWASSVTVLYAGLFLYSFAAaTVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYT 374
                        410
                 ....*....|....*....
gi 217502434 368 IWLAVVVIysmavPLVLLG 386
Cdd:cd17389  375 IGALLFLL-----PLLLLA 388
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
18-354 2.57e-28

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 114.20  E-value: 2.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  18 GIGLIFPILPRLLED--VTRTQniapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLW 95
Cdd:cd17474   14 GVSIVDPILPAIAEAlgASPAQ-----VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  96 MLLLGRAIAGLTSAN-VSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLL 174
Cdd:cd17474   89 LLLAGRALQGIGAAGlGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 175 ALFILPESRTPGRQKIDLAALNPLRPLRWvlsmKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFG 254
Cdd:cd17474  169 ILFLLPEPKEKAKSSSATKLRDLKKALRG----RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWS 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 255 VCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGS-IGTPALQALATRQVDEARQGQ 333
Cdd:cd17474  245 VLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGT 324
                        330       340
                 ....*....|....*....|.
gi 217502434 334 FQGVLASAVSLASIVAPLAFS 354
Cdd:cd17474  325 ASSLYNFVRFLGQAVGPLLFG 345
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
42-365 4.61e-25

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 105.00  E-value: 4.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITD 120
Cdd:cd17329   36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPAsEAMIAD 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 121 ISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALFILPESRTPGRQKIdlaALNPLRP 200
Cdd:cd17329  116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAE---KTEILRG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 201 LRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQwNGFWIglsLGAFGVCQTLVQALLPGPATKLLGE---RRA 277
Cdd:cd17329  193 YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG-LGESL---LGLLLALNALLIVLLQFPVARLVERfrlRKI 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 278 VLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTF 356
Cdd:cd17329  269 LMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGeMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348

                 ....*....
gi 217502434 357 YFVVQAEWP 365
Cdd:cd17329  349 LDLLGPGLP 357
MFS_1 pfam07690
Major Facilitator Superfamily;
8-350 5.42e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.64  E-value: 5.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434    8 IYATIGLDAVGIGLIFPILPRLLEDVTRTQniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVL 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS--PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   88 LAFAPQLWMLLLGRAIAGLT-SANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAA 165
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFLILA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  166 VLNACNFLLALFILPESRTPGRQKIDLAALNPLRPLRwVLSMKGLLPIIFVFFILSATGEAYGVcWALWGFDTFQWNGFW 245
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK-ALLRDPVLWLLLALLLFGFAFFGLLT-YLPLYQEVLGLSALL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  246 IGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG---SIGTPALQALA 322
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGfgfGLVFPALNALV 316
                         330       340
                  ....*....|....*....|....*...
gi 217502434  323 TRQVDEARQGQFQGVLASAVSLASIVAP 350
Cdd:pfam07690 317 SDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
44-363 5.14e-22

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 96.72  E-value: 5.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPqlWMLLLGRAIAGLTSANVSVATAYITDISP 123
Cdd:cd17387   39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 124 EDKRAGRFGLFNAMFGVGFIIGPVLGGLL----GDYWLRLPFIAAAVLNACNFLLAL-FILPESRTPGR--QKIDLAALN 196
Cdd:cd17387  117 EEERSTAYGLVSATFAASLVTSPALGAYLsesyGDNLVVLVATIVALLDICFILLAVpESLPEKMRPASwgAPISWEQAD 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 197 PLRPLRWVLSMKGLLPIIFVFFiLSATGEAyGV--CWALWGFDTFQWNGFWIGLSLGAFGVCQTLVQALLPGPATKLLGE 274
Cdd:cd17387  197 PFASLRKVGKDKTVLLICITVF-LSYLPEA-GQysSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGA 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 275 RRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFS 354
Cdd:cd17387  275 KNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFG 354

                 ....*....
gi 217502434 355 TFYFVVQAE 363
Cdd:cd17387  355 FVFYLFHVD 363
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
18-385 5.60e-22

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 96.12  E-value: 5.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  18 GIGLIFPILPRLLEDVTRTQNIApyiGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWML 97
Cdd:cd17489   11 SFYLLLPVLPLYAHDLGGSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  98 LLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLA 175
Cdd:cd17489   88 LVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLgFAVLFIVAAVLALLALLLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 176 LFILPESRTPGRQkidlaALNPLRPLRWVLSMKGLLPIIFVFFILSATGeAYGVCWALWGFDTFQWNgfwIGLSLGAFGV 255
Cdd:cd17489  168 FLVKDPPPVAAEE-----AEAGTRAFRRLVEKKVLPPALILFLASIAYG-AISTFLPLYAAERGISN---AGLFFTVYAI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 256 CQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQVDEARQGQF 334
Cdd:cd17489  239 ALLLSRPFS-GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAA 317
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 217502434 335 QGVLASAVSLASIVAPLAFStfyFVVQAEWPGAIWLAVVVIYSMAVPLVLL 385
Cdd:cd17489  318 NGTFFIFFDLGIGLGGLLLG---LVAELFGYRAMFLLAAVVVLLALVLYIF 365
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
16-352 1.08e-21

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 95.41  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  16 AVGIGLIFPILPRLLED--VTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ 93
Cdd:cd17391    9 GIGFSLIAPFLPLYIEQlgVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  94 LWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGD-YWLRLPFIAAAVLNACNF 172
Cdd:cd17391   89 VWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADlFGIRNVFFITGGLLFLAF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 173 LLALFILPESRTPGRQKIDLAalnPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFD--TFQWN-GFWIGLS 249
Cdd:cd17391  169 LLTLFFVKEDFKPVEKKKMVS---TKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQlmGDASNlAFISGLV 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 250 LGAFGVcQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGW--IVFAIMPIFALGSIgTPALQALATRQVD 327
Cdd:cd17391  246 FSATGV-SSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINSLLAKITP 323
                        330       340
                 ....*....|....*....|....*
gi 217502434 328 EARQGQFQGVLASAVSLASIVAPLA 352
Cdd:cd17391  324 KEVAGRIFGYNQSFQYLGNVAGPLL 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
1-179 1.19e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.34  E-value: 1.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   1 MNRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIApyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAG 80
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ--IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  81 AAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LR 158
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFgFA 354
                        170       180
                 ....*....|....*....|.
gi 217502434 159 LPFIAAAVLNACNFLLALFIL 179
Cdd:cd17325  355 TPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
40-375 2.32e-21

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 94.54  E-value: 2.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  40 APYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANV-SVATAYI 118
Cdd:cd17324   33 VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 119 TDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTPGRQKidlaaLNP 197
Cdd:cd17324  113 ADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS-----LGL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 198 LRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFGVCqTLVQALLPGPATKLLGERRA 277
Cdd:cd17324  188 LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA-GVVGSPLAGRLADRGGRRAL 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 278 VLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFY 357
Cdd:cd17324  267 LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
                        330
                 ....*....|....*...
gi 217502434 358 FVVQAEWPGAIWLAVVVI 375
Cdd:cd17324  347 DHGGWAGVGWVGAALLLL 364
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
41-370 2.94e-20

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 91.19  E-value: 2.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  41 PYIGIMIALYGIMQFIF----APVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQL------WMLLLGRAIAGLTSAN 110
Cdd:cd17386   26 VYAANFYLYMNLMGSIPplfsSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFttvpsvWWFYLSAIPLALFGGF 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 111 V---SVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL----GDYWLrlpFIAAAVLNACNFLLALFILpesr 183
Cdd:cd17386  106 TaflSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLfkalGYAWS---FSISAALLLIALLYILFFL---- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 184 tpgrqkidlaalnplrpLRWVLSMKGLLPIIFVFFILSATgeaygvcWALWGFDTFQWNGFWIGLSLGAFGVCQTLVQAL 263
Cdd:cd17386  179 -----------------TLLILLLLAAFLTIFVLSGESDV-------LYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLG 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 264 LPGPATKLLGERRAVL--VGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASA 341
Cdd:cd17386  235 GVLLLRCLLKMSDSTLamLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVL 314
                        330       340
                 ....*....|....*....|....*....
gi 217502434 342 VSLASIVAPLAFSTFYFVVQAEWPGAIWL 370
Cdd:cd17386  315 ESLSPLVASPIYNNIYKATLTTFPGFFFL 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
14-384 5.21e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 90.56  E-value: 5.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  14 LDAVGIGLIFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ 93
Cdd:cd06174    7 LTGLARGLISPLLPALLQSFGLS---ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  94 LWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY----WLRLPFIAAAVLN 168
Cdd:cd06174   84 FWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfgWRAVFLIAAALAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 169 ACNFLLALFILPESRTPGRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGL 248
Cdd:cd06174  164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 249 SLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQVD 327
Cdd:cd06174  244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFP 323
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434 328 EARQGQFQGVLASAVSLASIVAPLAFStfYFVVQAEWPGAIWLAVVVIYSMAVPLVL 384
Cdd:cd06174  324 PEIRGTAFGLLNTFGFLGGAIGPLLAG--FLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
5-356 7.44e-20

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 89.94  E-value: 7.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEdvTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAIN 84
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAPALPAIAQ--HFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  85 YVLLAFAPQLWMLLLGRAIAGLTSANV-SVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIA 163
Cdd:cd17473   79 GVAGLFLDSLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 164 AAVLNACNFLLALFILPESRTPGRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVcwalwgFDTFQWNG 243
Cdd:cd17473  159 YLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLL------QERGGGSA 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 244 FWIGLSLGAFGVCQTLVqALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALA 322
Cdd:cd17473  233 ALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWA 311
                        330       340       350
                 ....*....|....*....|....*....|....
gi 217502434 323 TRQVDEARQGQFQGVLASAVSLASIVAPLAFSTF 356
Cdd:cd17473  312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
5-325 5.37e-19

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 87.63  E-value: 5.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIAPY-IGIMIALYGIMQFIFapvlGALSDNLGRRPVLLISLAGAAI 83
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLtLSAYLLGFALGQLLY----GPLSDRFGRRPVLLAGLLLFIL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  84 NYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPF 161
Cdd:cd17320   77 ASLLCALASSIEQLLIARFLQGLgAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFgWRAIF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 162 IAAAVLNACNFLLALFILPESRTPGRQKIDLAALnpLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQW 241
Cdd:cd17320  157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSL--LRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 242 NGFWIGLSLGAFGVCqTLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAK--QGWIVFAIMPIFALGSIGTPALQ 319
Cdd:cd17320  235 SPAQFGLLFALNAIA-LILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllGGLSLWPLVAPLFLIFFGFGLIF 313

                 ....*.
gi 217502434 320 ALATRQ 325
Cdd:cd17320  314 PNATSL 319
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-351 1.89e-18

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 86.06  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   1 MNRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNiapYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAG 80
Cdd:COG0738    6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDA---QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  81 AAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITDISPEDKRAgRFGLFNAMFGVGFIIGPVLGGLL----GDY 155
Cdd:COG0738   83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAaNPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLillgLSL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 156 WLRLPFIAAAVLNACNFLLALFilpeSRTPGRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWG 235
Cdd:COG0738  162 SWHLPYLILAVLLLLLALLFLR----SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 236 FDTFQWNGFWIGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIG 314
Cdd:COG0738  238 KDVLGLSEATAALGLSLFWGGMTIGRFLG-GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlSLM 316
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 217502434 315 TPALQALATRQVDEARQGQFQGVLASAVSLASIVAPL 351
Cdd:COG0738  317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPL 353
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
56-349 3.10e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 85.30  E-value: 3.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  56 IFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSAN-VSVATAYITDISPEDKRAGRFGLF 134
Cdd:cd17321   46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLW 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 135 NAMFGVGFIIGPVLGGLLGDY-------WLRLPFIAAAVLNACNFLLALFILpesrtpgrqkidlaalnplrplrwvlsm 207
Cdd:cd17321  126 GAVVGIGAALGPLLGGLLLELfgwrwifLINVPIGLVALLLARTFSGAVLAA---------------------------- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 208 kgllpiifvfFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFGVCqTLVQALLPGPATKLLGERRAVLVGIACACI 287
Cdd:cd17321  178 ----------FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA-MLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 217502434 288 ALVAMAFAKQGWIVFAIMPIFALGSIGT----PALQALATRQVDEARQGQFQGVLASAVSLASIVA 349
Cdd:cd17321  247 GLLLLALLGADSSVWLLLPGLVLLGLGLglfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
7-375 3.61e-18

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 85.34  E-value: 3.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   7 VIYATIGLDAVGIGLIFPILPRLLEDVTRTQNiAPYIGIMIALYGIMQFIFAPVLGALSDNLG-RRPVLLISLAGAAINY 85
Cdd:cd17326    3 VMYLTMFLSSLQFSIVLTSIWPYLQKIDPTAT-ASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  86 VLLAFA-----PQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL-------G 153
Cdd:cd17326   82 ILYALAeyfpsNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFtpigypgY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 154 DYWLRLPF-------IAAAVLNACNFLLALFILPEsrtpgrqkidlaalnplrplrWVLsmkgllpiIFVFFILSATGEA 226
Cdd:cd17326  162 VIGIKLRFnmytapaWLMAILGIINIILILFFFKE---------------------VVC--------IFLFFVVLFIFAN 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 227 YGVCWALWGFDTFQWNG----FWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVLVGIACACIALVamaFAKQGWIVF 302
Cdd:cd17326  213 LETIGTPLTMDMYGWTReeavLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFV---VTLPWGITG 289
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217502434 303 AImpIFALG-SIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVI 375
Cdd:cd17326  290 VI--LFGLGyPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLL 361
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
43-349 2.91e-17

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 82.65  E-value: 2.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRR-PVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDI 121
Cdd:cd17490   33 IGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASY 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDLAALNPL-- 198
Cdd:cd17490  113 FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFgMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVlk 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 199 RPLRWVLSMKGllpiIFVFFILSATgeaygvcwaLWGFDT-----FQWNGFWIGLSLGAFGVCQTLVQALLPGPATKLLG 273
Cdd:cd17490  193 DKKLLFFSLLA----ILQQMITFST---------TFGFTPliakqLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLG 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 274 ERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGS-IGTPALQALATRQVDEARQ----GQFQGVLASAVSLASIV 348
Cdd:cd17490  260 ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRstamGFFQAIYALGMFLGPVL 339

                 .
gi 217502434 349 A 349
Cdd:cd17490  340 V 340
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
43-393 1.96e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 80.31  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTS-ANVSVATAYITDI 121
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKW 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTPGRQkidlAALNPLRP 200
Cdd:COG2223  122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA----AAKASLRD 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 201 LRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLV 280
Cdd:COG2223  198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG-GWLSDRIGGRRVLLI 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 281 GIACACIALVAMAFAKQGWIVF--AIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYF 358
Cdd:COG2223  277 VFALMALGLLLLALALGSLWLFlvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD 356
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 217502434 359 VVQAEWPGAIWLAVVVIYSMAVPLVLLGTRTARPA 393
Cdd:COG2223  357 ATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
56-178 1.87e-15

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 76.83  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  56 IFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANV-SVATAYITDISPEDKRAGRFGLF 134
Cdd:cd17502   45 AFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPPRERGKYQGYI 124
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 217502434 135 NAMFGVGFIIGPVLGGLLGDY-------WLRLPFIAAAVLNACNFLLALFI 178
Cdd:cd17502  125 GAVFGIASVAGPLIGGAFTDHlswrwcfYINLPIGGLALALLRTILLSSIF 175
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-255 6.99e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 74.46  E-value: 6.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAA 82
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGAS---SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  83 INYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY-WLRLP 160
Cdd:COG0477   91 LASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 161 FIAAAVLNACNFLLALFILPESRTPGRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQ 240
Cdd:COG0477  171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
                        250
                 ....*....|....*
gi 217502434 241 WNGFWIGLSLGAFGV 255
Cdd:COG0477  251 LLLLALLLLAALLLL 265
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
43-327 8.01e-15

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 75.33  E-value: 8.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGlTSANVSVATAYITDIS 122
Cdd:cd17472   34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 123 PEDKRA---GRFGLFNAM-FGVGFIIGPVLGGLLGDYWLrlpFIAAAVLNACNFLLALFILPESRtPGRQKIDLAALNPL 198
Cdd:cd17472  113 REENRTkamALIGASIGIaFAISMVLGPLLAAHLGVSGL---FLITAILSLVSLLILLFFVPDPP-KIVQISEKEKKKLK 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 199 RPLRwvlsMKGLLPIIFVFFILSATGEAYGVCW-----ALWGFDTFQWNGFWIGLsLGAFGVCQTLVqallpgpatkLLG 273
Cdd:cd17472  189 KLLK----NKRLLRLDFSIFILHFVLMAFFYILpllltQLGGGKGQLWKVYLPAI-LIGFILMVPFV----------IYA 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 274 ERRAVLVGIACACIALVAMAF------AKQGWIVFAIMPIFALG-SIGTPALQALATRQVD 327
Cdd:cd17472  254 EKKGKMKQVFVSSILLIAVGFllllfaATSLWLLIIGLIIFFIGfNLLEALLPSLVSKIAP 314
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
3-207 9.68e-15

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 75.34  E-value: 9.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLED--VTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAG 80
Cdd:PRK09874  14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQlgVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  81 AAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLP 160
Cdd:PRK09874  94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRP 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 217502434 161 --FIAAAVLNACnFLLALFILPESRTPGRQKIDLAA---LNPLRPLRWVLSM 207
Cdd:PRK09874 174 vfFITASVLFLC-FLVTLFCIRENFQPVSKKEMLHMrevVTSLKNPKLVLSL 224
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-391 1.45e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 74.52  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLeDVTRTQniapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAIN 84
Cdd:COG2271   15 LFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQ-----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  85 YVLLAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFI 162
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 163 AAAVLnacNFLLALFilpesrtpgrqkidlaalnplrplrwvlsmkGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWN 242
Cdd:COG2271  169 ILGLP---GLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 243 GFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRAVL-VGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGT-PALQA 320
Cdd:COG2271  215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLaIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAfGLLWA 294
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 321 LATRQVDEARQGQFQGVLASAVSLASIVAPLAFStfYFVVQAEWPGAIWLAVVVIYSMAVPLVLLGTRTAR 391
Cdd:COG2271  295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVG--YLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
33-385 2.56e-14

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 73.80  E-value: 2.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  33 VTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAP-----QLWMLLLGRAIAGLT 107
Cdd:cd06173   26 VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 108 SANVSVA-TAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL-GDYWLRLPFIAAAVLNACNFLLALFILPESRTP 185
Cdd:cd06173  106 SAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 186 GRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFGVcQTLVQALLP 265
Cdd:cd06173  186 PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLL 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 266 GPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQVDEARQGQFQGVLASAVSL 344
Cdd:cd06173  265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAgGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSG 344
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 217502434 345 ASIVAPLAFSTFYFVVqaEWPGAIWLAVVVIYSMAVPLVLL 385
Cdd:cd06173  345 AMPLGALLAGLLADAL--GLSAVFLLAGALLLLAALLLLLL 383
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
8-304 2.67e-14

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 73.74  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   8 IYATIGLDAVGIGLIFPILPRLLEDVTRTQNIapYIGIMIALYGIMQFIFAPVLGALSD-NLGRRPVLLISLAGAAINYV 86
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPL--QIGIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGYL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  87 LLAFAPQLWMLLL-GRAIAGLTSANVSVATAYI---TDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPF 161
Cdd:cd17471   79 LFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLgFTGLF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 162 IAAAVLNACNFLLALFILPESRTPgRQKIDLAALNPLRPLRWVlsmkgLLPIIFVFFILSATGEAYGVCWALWGFDTFQW 241
Cdd:cd17471  159 LLAALLYLVVALLVLFLLPSVKPP-AQKATPASSLVKAPVNRR-----LLLLFAAFTLLFAANSMYIIAMPLYVTNELGG 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 217502434 242 NGFWIGLSLGAFGVCQTLVQALLPGPATKlLGERRAVLVGIACACIALVAMAFAKQGWIVFAI 304
Cdd:cd17471  233 SESWVGLLFGLAAALEIPIMLLAGLLAKR-FGKRRLLLAGFLAGVLFYLGLALATSLWQLIAL 294
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
43-176 3.03e-13

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 70.26  E-value: 3.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDI 121
Cdd:cd17370  236 IPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADL 315
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGD-YWLRLPFIAAAVLNACNFLLAL 176
Cdd:cd17370  316 VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDlISPSAAFLFSAVLALIALLLLL 371
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
8-380 7.16e-13

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 69.12  E-value: 7.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   8 IYATIGLDAVGIGLIFPILPRLLEDvtrtQNIAP-YIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYV 86
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLER----EGVSTaLIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  87 LLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIAAA 165
Cdd:cd17477   77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 166 VLNACNFLLALFILPESRTPGRQKIDLAALnplrplrwVLSMKGLLPIIFVFFILSATGEAYGVCWALwgfdTFQWNGFW 245
Cdd:cd17477  157 LLLLALVPLLLTRRAAPEIEEAESISLRRL--------LRIAPLALLGAFVAGFLEGAFYSLLPLYGL----RLGLSVAQ 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 246 IGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGT--PALQALAT 323
Cdd:cd17477  225 AALLLAAFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlyTLALALAG 303
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434 324 RQVDEARQGQFQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVIYSMAV 380
Cdd:cd17477  304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
25-305 1.42e-12

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 68.42  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  25 ILPRLLEDVTRTQNIAPYIGIMIALYGIMQF-IFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAI 103
Cdd:cd17328   17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYmVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 104 AGLTSANVS-VATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWL--RLPFIAAAVLNACNFLLALFILP 180
Cdd:cd17328   97 VGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwRWAFRVTGVLGVLLAILLLLFVR 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 181 EsrtPGRQKIDLAALNPLRPLRWVLSMKGLLP------IIFVFFILSATGEAYGVCWALWGFDTFQWN-------GFWIG 247
Cdd:cd17328  177 E---PPRGAAEGGVMAKSTATSFLADLKALAKnpsfilSTLGFTAVSFVTGALAFWAPTFFLRAFGVGdlssadvGLIFG 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 217502434 248 LSLGAFGVCQTLVQALLpgpaTKLLGERRA---VLVG----IACACIALVAMAFAKQGWIVFAIM 305
Cdd:cd17328  254 AITCIAGVLGVLLGGIL----ADRLRRKTPradPLVCavglLAAAPFLFLALVLALSNLLLAWVL 314
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
4-179 1.66e-12

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 68.06  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   4 PLLVIYATIGLDAVGIGLIFPILPRLLEDVT-RTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAA 82
Cdd:cd17391  202 LLISLFVTTFIIQLANQSIEPILTLYIRQLMgDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASA 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  83 INYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLP 160
Cdd:cd17391  282 LLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFgYRAV 361
                        170
                 ....*....|....*....
gi 217502434 161 FIAAAVLNACNFLLALFIL 179
Cdd:cd17391  362 FVVTALLVLLNAIWSFIFL 380
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
42-359 4.78e-12

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 66.88  E-value: 4.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSD----NLGRR-PVLLISLAGAAINYVLLAFAPQLWMLLLGR--------AIAGLTS 108
Cdd:cd17313   35 LIGFVWTLGPILGLFVQPLVGSLSDrcnsRIGRRrPFILVGAPLAALGLILIPNAADIGLALGDGprtwalvlFVLGIVL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 109 ANVSVAT------AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY---------WLRLPFIAAAVLNACNFL 173
Cdd:cd17313  115 LDFAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHnwfgfalggNLKVPFYIGAIILLVCVL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 174 LALFILPESRTPGR-QKIDLAALNPLRPLRWVL-------SMKGLLPIIFVFFILSATGEAYGVCWA---LWGFDTFQWN 242
Cdd:cd17313  195 VTLFFVKEPPLSPEaGEHSENPSLGEVLKSLLKllkimprSLLRLLLVIFFWWIAFFPFELFFTDYMgeeVYHGTSAASS 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 243 GFWIGLSLGAFGVCQ----TLVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAimpIFALGSIGTPAL 318
Cdd:cd17313  275 HYGAGVRMGAWGLLIfslaFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALV---LFALGGIGWATI 351
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 217502434 319 Q----ALATRQVDE--ARQGQFQGVLASAVSLASIVAPLAFSTFYFV 359
Cdd:cd17313  352 NinpyPLVSDYHSEsgRGQGTDTGLLNLAISLAQILVSLLAGPIIDV 398
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
21-389 5.59e-12

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 66.45  E-value: 5.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  21 LIFPILPRLLEDVTRTQNIAPYIgimIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLG 100
Cdd:cd17504   14 MLSPALPTIQREFGTSAAAVSWV---LTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 101 RAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLnacnFLLALFIL 179
Cdd:cd17504   91 RALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLgWRWIFWTAAPV----AVLLAALV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 180 PesrtpgrqKIDLAALNplRPLRWVLSMKGLLpIIFVFFILSATGEAYGV--CWALWGFDTFQwngfwIGLSLGAFGVCQ 257
Cdd:cd17504  167 P--------LIDLRLLR--RRNVLLANITALL-AGFGMFMVFQLLPQLLQlpTPTGFGLGITE-----AGLLLLPGALVM 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 258 TLVqALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQG-WIVFAIMPIFALG-SIGTPALQALATRQVDEARQGQFQ 335
Cdd:cd17504  231 LIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGlGLAFASLPNIVVESVPPDRTGIAT 309
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 336 GVLASAVSLASIVAPL-------AFSTFYFVVQAEWPGAIWLAVVVIYSMAVPLVLLGTRT 389
Cdd:cd17504  310 GMNTVLRTIGSAIGPAiagailtTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
43-353 6.12e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 66.85  E-value: 6.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLG-----RRPVLLISLAGAAINYVLLAFAP------QLWMLLLGRAIAGLTSANV 111
Cdd:COG2211   48 VGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPdlsptgKLIYALVTYLLLGLAYTLV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 112 SVA-TAYITDISPE-DKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-------LRLPFIAAAVLNACNFLLALFILPES 182
Cdd:COG2211  128 NIPySALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalgYRLTALIFAVLGLLAFLLTFFGTKER 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 183 RTPGRQKI----DLAALNPLRPLRWVLSMKGLlpIIFVFFILSATGEAYGVcwalwgfDTFQWNGFWIGLSLGAFGVCQT 258
Cdd:COG2211  208 PVPEEEKVslkeSLKALLKNRPFLLLLLAYLL--FFLALALVAALLLYYFK-------YVLGLSAALVGLLLALYFLAAL 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 259 LVQALLPgPATKLLGERRAVLVGIACACIALVAMAFAKQG--WIVFAIMPIFALG-SIGTPALQALATRQVDEA------ 329
Cdd:COG2211  279 LGAPLWP-RLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDewktgr 357
                        330       340
                 ....*....|....*....|....*
gi 217502434 330 -RQGQFQGVLASAVSLASIVAPLAF 353
Cdd:COG2211  358 rREGLYFGIFTFAIKLGQALAGALA 382
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
43-181 6.45e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 66.44  E-value: 6.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPvlgaLSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANV-SVATAYITDI 121
Cdd:cd17323   40 VSLFVLGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADL 115
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPE 181
Cdd:cd17323  116 FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLgWRWIFWFLAIISGFCLILIFLFLPI 176
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
43-322 5.12e-11

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 63.73  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDIS 122
Cdd:cd17478   33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 123 PEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIAAAVLNAcnfLLALFILPESRTPGRQKIDLAALNPLRPLR 202
Cdd:cd17478  113 AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG---LAVALLLLRLRPLKKPEAKKAAAKSSARST 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 203 WVLSMKGLLPIIFVFFILSATGEAYGVCWALWGFDTFQwNGFWIGLSLGAFGVCQTLVQaLLPGPATKLLGERRAVLVGI 282
Cdd:cd17478  190 LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGY-SLVFAGLLLSLFLFAGAIGT-LIGGPLSDRFGRRRVIIASL 267
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 217502434 283 ACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALA 322
Cdd:cd17478  268 LLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
62-183 7.46e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 62.98  E-value: 7.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  62 GALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRaGRFGLFNAMFG- 139
Cdd:cd17315   55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEIAPAKIR-GALGTLNQLMIt 133
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 217502434 140 VGFIIGPVLGGLLGDY---WLRLPFIAAAVLnACNFLLALFILPESR 183
Cdd:cd17315  134 FGILLAYLLGLALSLSppgWWRLMFALAAVP-ALLQLLLMFFLPESR 179
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
5-186 1.32e-10

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 62.20  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIFPILPRLLEDvtrtqNIapYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAIN 84
Cdd:cd17384    2 LVIVYVALLLDNMLLTVVVPIIPDYLNE-----NV--RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFIS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  85 YVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITDISPEDKRAGR-FGLFNAMFGVGFIIGPVLGGLLGDYWLR-LPF 161
Cdd:cd17384   75 TLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLYPDDKERGKaMGIALGGLALGVLVGPPFGGVMYEFVGKsAPF 154
                        170       180
                 ....*....|....*....|....*
gi 217502434 162 IAAAVLNACNFLLALFILPESRTPG 186
Cdd:cd17384  155 LILAFLALLDGALQLFILQPSVKSE 179
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
43-304 1.38e-10

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 62.22  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLG-RRPVLLISLAGAAINYVLLAFAPQ-LWMLLLGRAIAG-LTSANVSVATAYIT 119
Cdd:cd17335   34 IGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQiFWLLLLLVILGAfFSAPVVPLVDSITL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 120 DIspEDKRAGRFGLFNaMFG-VGFIIGPVLGGLLGDYW-----LRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDLA 193
Cdd:cd17335  114 QY--LGEERERYGKQR-LWGsIGFGIAALLVGILIDRSstyknYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGG 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 194 ALNPLRPLRWVLSMkgllpiIFVFFILSATGEAYGvcWALWGFDTFQWNGFWIGLSLgAFGVCQTLVQALLPGPATKLLG 273
Cdd:cd17335  191 LLALLRNPRVLAFL------LVAFLMGFGHGLIYS--FLFWHLQDLGGSKTLIGLLW-TVGVVSEIPFFFFSSRLIQRFG 261
                        250       260       270
                 ....*....|....*....|....*....|.
gi 217502434 274 ERRAVLVGIACACIALVAMAFAKQGWIVFAI 304
Cdd:cd17335  262 HVGLLYLGLLAYVVRWLLYSFLENPWLVLPI 292
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
42-397 7.01e-10

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 60.17  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSDNLGRR-PVLLISLAGAAINYVLLAFAP--QLWMLLLGRAIA--GLTSANVSVAtA 116
Cdd:COG2270   53 LWGYALAIAGLLVALLAPVLGAIADRSGRKkPFLAFFTLLGVLATAALFFVApgGLWLGLLLFVLAniGFEGSLVFYN-A 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 117 YITDISPEDKRAGRFGLFNAMFGVG----------FIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTP 185
Cdd:COG2270  132 FLPDIATPEEIGRVSGLGWALGYLGgvllllinlaLFLKPEAFGLPDAGEaVRISFLLTALWWLLFALPLFLFLPERPRP 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 186 GRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILS-----------ATGEAYGVcwALWGFDTFQWNGFWIGLSLGAFg 254
Cdd:COG2270  212 GPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYffyrdgvqtviAFAGIYAA--GVLGFSTTELIVFGLLVQIVAA- 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 255 vcqtlVQALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPAL-QALATRQVDEARQGQ 333
Cdd:COG2270  289 -----LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALsRSLLARLIPPGREAE 363
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217502434 334 FQGVLASAVSLASIVAPLAFSTFYFVVQAEWPGAIWLAVVVIYSMavpLVLLGTRTARPARPAS 397
Cdd:COG2270  364 FFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGL---VLLLRVKVPRGRAAAG 424
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
5-182 7.08e-10

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 60.28  E-value: 7.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   5 LLVIYATIGLDAVGIGLIF--PILPRLLEDVTRTQNIAP----YIGIMIALYGIMQFIFApvlGALSDNLGRRPVLLISL 78
Cdd:cd17358    2 LATFVANLGSFSFGIAVGWssPALPSLMSDNSLSLPLTVaqfsWFGSLLTLGALIGALLS---GKLADRIGRKRTLLISA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  79 AGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVS-VATAYITDISPEDKRaGRFGLFNAMFGV-GFIIGPVLGGLLgdYW 156
Cdd:cd17358   79 IPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASvVVPVYIAEIAPKNVR-GALGSLNQLLVNiGILLGYVLGSFL--PW 155
                        170       180
                 ....*....|....*....|....*.
gi 217502434 157 LRLPFIAAAVLNAcnFLLALFILPES 182
Cdd:cd17358  156 RTLALIGAIPPVV--FLILLFFIPES 179
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
2-178 1.07e-09

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 59.52  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   2 NRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGA 81
Cdd:cd17335  197 NPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTL---IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAY 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  82 AINYVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITDISPEDKRAGRFGLFNAM-FGVGFIIGPVLGGLLGDYW-LR 158
Cdd:cd17335  274 VVRWLLYSFLENPWLVLPIELLHGLTFALVWAAaVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSLIGGYLYEAFgAR 353
                        170       180
                 ....*....|....*....|
gi 217502434 159 LPFIAAAVLNACNFLLALFI 178
Cdd:cd17335  354 TTFRFFAIAALAGLLAFFLI 373
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
2-152 1.20e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.53  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   2 NRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTrtQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGA 81
Cdd:COG2211  227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  82 AINYVLLAFAP--QLWMLLLGRAIAGLTSANV-SVATAYITDISPEDK------RAGR-FGLFNAMFGVGFIIGPVLGGL 151
Cdd:COG2211  305 ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAIlVLPWAMLADVVDYDEwktgrrREGLyFGIFTFAIKLGQALAGALAGL 384

                 .
gi 217502434 152 L 152
Cdd:COG2211  385 L 385
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
42-179 3.16e-09

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 58.00  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSDNLG-RRPVLLISLAGAAINYVLLAFAP------QLWMLLLGRAIAGLTSANVSVA 114
Cdd:cd17385  237 QVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVGFLLLGPAPllpiksELWMVIIGLVLLGLSLGAALVP 316
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434 115 TayITDISPEDKRAGrF-----------GLFNAMFGVGFIIGPVLGGLLGDywlRLPF-IAAAVLNACNFLLALFIL 179
Cdd:cd17385  317 T--FPELLNCAREYG-FpdnlstyglvsGLFNAAFSLGAFIGPTLGGFLLE---RLGFeWAATIQAGLAFVVGILMS 387
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
60-357 4.24e-09

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 57.90  E-value: 4.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWM----LLLGRAIAGLT---SANVSVATAYITDISPEDKRAGRFG 132
Cdd:cd17449   84 LLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLhvayFLIGRILSGLLgdfNGILAGCFAYVADVSDRRSRTFRVA 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 133 LFNAMFGVGFIIGPVLGGllgdYWLRL-----PFIAAAVLNACNFLLALFILPESRTPG----------RQKIDLAALNP 197
Cdd:cd17449  164 VLEACLGLAGMLASIIGG----QWRKAqgyinPFWLVLALNLAAALYAAFCVGESVKEPksarlfttrhHQSVVRLYVAP 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 198 LRPLR----WVLSMKGLLPI--------IFVFFILSatgeaYGVCWA--LWGFDTFQWNGFWIGlSLGAFGVCQTlvqal 263
Cdd:cd17449  240 APNGSrrklALYSLALFVVVtvhfgakdLLVLYELS-----SPLCWDsdLIGYGSAAEHLTYLS-SLLGLRLLQL----- 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 264 lpgpatkLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASAVS 343
Cdd:cd17449  309 -------CLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEG 381
                        330
                 ....*....|....
gi 217502434 344 LASIVAPLAFSTFY 357
Cdd:cd17449  382 LCSLVATGIFNSLY 395
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
48-156 9.37e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 56.43  E-value: 9.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  48 ALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDK 126
Cdd:cd17317   32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGMEIVGPKY 111
                         90       100       110
                 ....*....|....*....|....*....|
gi 217502434 127 RAGRFGLFNAMFGVGFIIGPVLGGLLGDYW 156
Cdd:cd17317  112 RSFVGILFGLFWALGYMLLALLAYLIRDWR 141
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
55-182 1.28e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 56.56  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   55 FIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAgRFGL 133
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAvVLNTEFLPKKQRA-IVGT 219
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 217502434  134 FNAMF-GVGFIIGPVLGGLLGDY-----WLRLPFIAaavlnacnFLLALFILPES 182
Cdd:TIGR00898 220 LIQVFfSLGLVLLPLVAYFIPDWrwlqlAVSLPTFL--------FFLLSWFVPES 266
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
43-177 1.64e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 55.69  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDN-LGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITD 120
Cdd:cd17490  232 LGLLSIIYLLPNALASLLSGTLFYKkLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGiLFPLLMSLSIE 311
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 217502434 121 ISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALF 177
Cdd:cd17490  312 GVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFgLQTGFFVIGVIALLAAILSLA 369
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
43-393 3.14e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 55.26  E-value: 3.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDIS 122
Cdd:COG2807   55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 123 PEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTPGrqkidlAALNPLRPL 201
Cdd:COG2807  135 FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALgWRGALAVWALLALLALLLWLPLLRRRPAAA------AAAPAAASL 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 202 RWVLSMKGLLPIIFVFFILSATgeAYGVcwALWGFDTFQWNGF---WIGLSLGAFGVCQTLVQALLPGPATKLLGERRAV 278
Cdd:COG2807  209 RSLWRSPLAWLLTLFFGLQSLL--YYAV--VAWLPPILRDAGLsaaTAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 279 LVGIACACIALVAMAFAKQGWIVFAIMPI-FALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFSTFY 357
Cdd:COG2807  285 LLLGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALH 364
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 217502434 358 fvvqaEWPGAIWLAVVVIYSMAVPLVLLGTRTARPA 393
Cdd:COG2807  365 -----DATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
56-156 6.44e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.12  E-value: 6.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  56 IFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSAN-VSVATAYITDISPEDKRAGRFGLF 134
Cdd:cd17503   46 IMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLV 125
                         90       100
                 ....*....|....*....|..
gi 217502434 135 NAMFGVGFIIGPVLGGLLGDYW 156
Cdd:cd17503  126 GLVILLAPAIGPTLGGWLTDNL 147
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
43-179 1.63e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.60  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDI 121
Cdd:cd17316   38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEF 117
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWL-----RLPFIAAAVLNACNFLLALFIL 179
Cdd:cd17316  118 APSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgwRILFLIGALPALLALLLRRRTL 180
Sugar_tr pfam00083
Sugar (and other) transporter;
29-182 1.71e-07

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 53.04  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   29 LLEDVTRTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ---LWMLLLGRAIAG 105
Cdd:pfam00083  34 LSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  106 LTSANVSV-ATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY-----WlRLPFIAAAVLNACNFLLALFiL 179
Cdd:pfam00083 114 IGVGGASVlAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTsnsdgW-RIPLGLQLVPALLLIIGLLF-L 191

                  ...
gi 217502434  180 PES 182
Cdd:pfam00083 192 PES 194
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
43-177 2.01e-07

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 52.64  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIF-APVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDI 121
Cdd:cd17388  244 VGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQ 323
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 122 SPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL----GDYWLRLPFIAAAVLNACNFLLALF 177
Cdd:cd17388  324 VPENEQGELQGVLTSLTSLTSIIGPLLFTGIfaasPATWPGLAWIIGAALYLICLVLAYR 383
emrD PRK11652
multidrug transporter EmrD;
50-194 3.03e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 51.83  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  50 YGIMQFIFAPvlgaLSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYItdisPEDKRAG 129
Cdd:PRK11652  56 YGLSQLFYGP----LSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTL----PRDLYEG 127
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 130 R-FGLFNAMFGVGFI----IGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDLAA 194
Cdd:PRK11652 128 TqLRHANSLLNMGILvsplLAPLIGGLLTTLFgWRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLA 198
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
62-182 3.13e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 51.80  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  62 GALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSV-ATAYITDISPEDKRAGRFGLFNAMFGV 140
Cdd:cd17359   57 GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASAlVPMYIAEVAPAEIRGRLVSLNQLMIVF 136
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 217502434 141 G----FIIGPVLGGLLGDYWLRLP----FIAAAVLNACNFLLALFILPES 182
Cdd:cd17359  137 GqllaYIVNYLIANAGGADWLGAEgwrwMLGLEAIPAILFLLGMLFIPES 186
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
50-191 3.98e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 52.00  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   50 YGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRA 128
Cdd:TIGR00711  46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFgGGPLIPLSFSTLLNIYPPEKRG 125
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217502434  129 GRFGLFNAMFGVGFIIGPVLGG-LLGDYWLRLPFIAAAVLNACNFLLALFILPESRTPGRQKID 191
Cdd:TIGR00711 126 RAMAIWGLTVLVAPALGPTLGGwIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASENFD 189
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
55-185 5.88e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 51.12  E-value: 5.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  55 FIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSV-ATAYITDISPEDKRAGRFGL 133
Cdd:cd17360   49 AVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMtVPLYIAEAAPPRIRGRLVTI 128
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 217502434 134 FNAMFGVGFIIGPVLGGL---LGDYWlRLPFIAAAVLNACNFLLALFILPESRTP 185
Cdd:cd17360  129 NVLFITGGQFVAYVINGAfsyLPGGW-RWMLGLAAVPAVLQFIGLLFLPESPRWP 182
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
2-178 1.17e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 50.31  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   2 NRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIApyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGA 81
Cdd:cd06173  207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG--YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  82 AINYVLLAFAPQLWMLLLGRAIAGLTSANVSV-ATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRL 159
Cdd:cd06173  285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVpLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALgLSA 364
                        170
                 ....*....|....*....
gi 217502434 160 PFIAAAVLNACNFLLALFI 178
Cdd:cd06173  365 VFLLAGALLLLAALLLLLL 383
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
43-351 1.71e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 49.63  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDI 121
Cdd:cd17333   33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLgAGILDTGANTFVGAL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 122 SPEdKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYWLR--LPFIAAAVLNACNFLLALFILPESRtpgrqkiDLAALNPLR 199
Cdd:cd17333  113 FEE-SSATRLNVLHGFFGLGALIGPLIATSLLTSELSwsWAYLIIGLIYLLLAILILLTLFPEL-------PSARNPQQS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 200 PLRWVLSMKGLLPIIFVFFILSATGEAYGVCWALWGF-DTFQWNGFWIGLSLGAFGVCQT----LVQALLPGPATKLLGE 274
Cdd:cd17333  185 VGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWvPSYLVEKKHVSDGLAGYLLSGFwvgiTIGRLLGGPISRRIKP 264
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 217502434 275 RRAVLVGIACACIALVAMAFAKQG-WIVFAIMPIFALGSIGTPALQALATRQVDEArQGQFQGVLASAVSLASIVAPL 351
Cdd:cd17333  265 HTLLVLSGSGALLGLLILLLAPTLvVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTSVLLAAGSIGGAIIPF 341
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
44-182 4.92e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.41  E-value: 4.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFA---PQLWMLLLGRAIAGLTSANVSVATA-YIT 119
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPmYLQ 131
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217502434 120 DISPEDKRagrfGLFNAMFGVGFIIGPVLGGLLGdywlrLPFI-----------AAAVLNACNFLLALFILPES 182
Cdd:cd17357  132 EISPSELR----GALGSLTQIGVTLGILLGQVFG-----LPSVlgtetlwpyllFFPGIPALLQLAALPFFPES 196
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
1-194 5.33e-06

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 48.09  E-value: 5.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   1 MNRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQnIAPYIGIMIALYGIMQ-FIFApvlGALSDNLGRRPVLLISLA 79
Cdd:PRK10473   1 MSRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASE-AQLHIAFSVYLAGMAAaMLFA---GKIADRSGRKPVAIPGAA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  80 GAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGL--LGDYW 156
Cdd:PRK10473  77 LFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAfAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLimLKFPW 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 217502434 157 LRLpFIAAAVLNACNFLLALFILPESRtPGRQKIDLAA 194
Cdd:PRK10473 157 QSL-FYTMAAMGILVLLLSLFILKETR-PARAPAASSK 192
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
52-370 6.06e-06

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 47.80  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  52 IMQFIFAPVLGALSDNLGRRPVLLISLAGAAIN---YVLLA-FAPQLWMLLLGRAIAGLTSanvSVAT------AYITDI 121
Cdd:cd17448   80 IPSLIVTLILVSYSDRHGRKFSIILPSIGALLTslsYCLVSyFSFPLNLLIASSFISGLFG---GFTTfiggcfAYVADL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 122 SPEDK-RAGRFGLFNAMFGVgfIIGpvLGGLLGDYWLR-----LPFIAAAVLNACNFLLALFILpesrtpgrqkidlaal 195
Cdd:cd17448  157 CKDHKqKTIRMAVVDMILGV--LTG--LAGLSSGYFIRalgfnWPFLTIALLHVVNLLYILFFL---------------- 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 196 nplrplrWVLSmkgLLPIIFVFFILSATGEAygVCWALWGFDT-FQWNGFWIGLSLGAFGVCqTLVQALLPGPATKLLGE 274
Cdd:cd17448  217 -------VVLC---LLLFAFSTYLLANFGGA--SIFILYELNApLCWNEVLVGYGSAASTAI-FLTSFVGVALFSRCLPD 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 275 RRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAFS 354
Cdd:cd17448  284 IYIVFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFN 363
                        330
                 ....*....|....*.
gi 217502434 355 TFYFVVQAEWPGAIWL 370
Cdd:cd17448  364 SIYAATVAWFPGFSFL 379
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
6-179 7.72e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 47.64  E-value: 7.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   6 LVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIAPYIgimIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINY 85
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWL---AASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  86 VLLAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAG-RFGLFNAMFGVGFIIGPVLGGLLGDY-WLRLPFI 162
Cdd:cd17476   78 LIAGFSPNFIFFIICRALQGLGPAfLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLaWWPWIFW 157
                        170
                 ....*....|....*..
gi 217502434 163 AAAVLNACNFLLALFIL 179
Cdd:cd17476  158 FLAILAAIVAVAAIFWT 174
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
61-202 8.02e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 47.38  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   61 LGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFG 139
Cdd:TIGR00710  60 WGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLA 139
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434  140 VGFIIGPVLGGLLgDYWLRLPFIaAAVLNACNFLLAL---FILPESRTP-GRQKIDLAALNPLRPLR 202
Cdd:TIGR00710 140 LAPAVAPLLGGYI-LVWLSWHAI-FAFLSLAGILLSAlifFILPETLPYeARIQISTYFETFLLLLK 204
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
47-182 8.84e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 47.35  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   47 IALYGIMqfIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPED 125
Cdd:TIGR00895  60 AGLIGMA--FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKR 137
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 217502434  126 KRAGRFGLFNAMFGVGFIIGPVLGGLLG-DYWLRLPFIAAAVLNACNFLLALFILPES 182
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPES 195
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
2-179 9.54e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 9.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   2 NRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGA 81
Cdd:cd17473  196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS--AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  82 AINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGdywLRLP 160
Cdd:cd17473  274 ALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV---NLTG 350
                        170
                 ....*....|....*....
gi 217502434 161 FIAAAVLNACNFLLALFIL 179
Cdd:cd17473  351 GLSGAFLILGVLALVLAIV 369
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
43-179 1.25e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 46.83  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGltsaNVSVATAYITDIS 122
Cdd:cd17353   40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLG----GIGAGIGYITPVS 115
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 217502434 123 P-----EDKRAGRFGLFNAMFGVG-FIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALFIL 179
Cdd:cd17353  116 TavkwfPDKRGLATGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
62-294 1.66e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 46.53  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  62 GALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYIT-DISPEDKRAGRFGLFNAMFGV 140
Cdd:cd17371   55 GILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMaEYVPARHRGKALGYVQSGWAV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 141 GFIIGPVLGGLL-GDYWLRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDLAALN--PLRPLRWVLSMKGLLPIIFVF 217
Cdd:cd17371  135 GWLLATLLAALLfPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRhfADRPSLRELFSPPLLRTTLLA 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 218 FILSATgeAYGVCWALWGFD----------TFQWNGFWIGLSlgafgVCQTLVQALLPGPATKLLGERRAVLVGIACACI 287
Cdd:cd17371  215 SLLATG--ALGGYYGITTWLpsyltgerglSFEGSAGYLVVT-----ILGGFLGYLAGGFLADRIGRRNNFALFALGSAI 287

                 ....*..
gi 217502434 288 ALVAMAF 294
Cdd:cd17371  288 SILLYFF 294
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
47-153 1.89e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.42  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  47 IALYGIMqfIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPED 125
Cdd:cd17365   42 AALFGMA--IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPAR 119
                         90       100
                 ....*....|....*....|....*...
gi 217502434 126 KRagrfGLFNAMFGVGFIIGPVLGGLLG 153
Cdd:cd17365  120 RR----SLAVTLMFCGYPLGAALGGFLA 143
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
46-192 2.20e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.21  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   46 MIALYGIMQFIFapvlGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPE 124
Cdd:TIGR00881  39 FSIAYGISKFVM----GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIfQGMGWPPCGRTVTKWFSR 114
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434  125 DKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY---WLRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDL 192
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGGGLLPPLVLFGIAElysWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
40-323 2.42e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 46.15  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   40 APYIGIMIALYGIMQFIFAPVLGALSDNLG-----RRPVLLISLAGAAINYVLLAFAPQ-----------LWMLLLGRAI 103
Cdd:pfam13347  32 AAAVGLVLLVARLVDAFTDPIVGHIIDRTRtrwgrRRPWLLLSAIILAVSFILLFTPPElgraplfiwllATYILLRIAY 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  104 AGLTSANVSVAtAYITDISPEDKRAGRFGLFNAMFG---VGFIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALFIL- 179
Cdd:pfam13347 112 TFFEIPYWSLG-PELTRDYDERTSLTSYRSFFSVGGgllAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITa 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  180 -----PESRTPGRQKIDLAALNPLRPLRWVLSMKGLLpIIFVFFILSATGEAYGVCWALWGFDTFQWNGFWIGLSLGAFG 254
Cdd:pfam13347 191 agtkeRVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFL-ILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFT 269
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434  255 VCQTLVQALLPgPATKLLGERRAVLVGIaCACIALVAMAFAKQGWIVFAIMPIFALGSIGTPALQALAT 323
Cdd:pfam13347 270 IGALLGIPLWP-PLAKRIGKKNTYILGA-LITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPW 336
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
42-174 2.67e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 46.00  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLT-SANVSVATAYITD 120
Cdd:cd17471  236 WVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFiGITAGLGISYFQD 315
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434 121 ISPedkraGRFG----LFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLL 174
Cdd:cd17471  316 LMP-----GQPGlattLYSNASRIGSLLGGLLAGVIAQYFgYRAVFLVCAVLALLALVL 369
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
43-357 2.72e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 45.72  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVS--VATAYITD 120
Cdd:cd17355   40 ISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLaaVAFATVAA 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 121 ISPEDKRAGRFGLFNAMFGVG-FIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALFILPESRTPGRQKIDLAALN--P 197
Cdd:cd17355  120 WWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPasP 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 198 LRPLRWVLSMKGLLPIIFVFFILSATGeaYGVCWALWGF-DTFQWNGFWIGLSLGAFGVCQtLVQALLPGPATKLLGERR 276
Cdd:cd17355  200 GSTLKEALRSASFWLLALAFFLCGFAV--VGLIVHLVPYlADRGISPAAAAVALALIGLFN-IVGRLLSGWLGDRYSPRR 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 277 AVLVGI---ACACIALVAMAFAKQGWIVFAIMpiFALGSIGT-PALQALATRQVDEARQGQFQGVLASAVSLASIVAPLA 352
Cdd:cd17355  277 LLAASYalrALGLALLLLLPFPPLALLLFAAL--FGLGWGATvPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL 354

                 ....*
gi 217502434 353 FSTFY 357
Cdd:cd17355  355 GGLLY 359
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
3-185 4.67e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 45.30  E-value: 4.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   3 RPLLVIYATIGLDAVGIGLIFPILPRLLEDVT-RTQNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGA 81
Cdd:PRK09874 219 KLVLSLFVTTLIIQVATGSIAPILTLYVRELAgNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFS 298
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  82 AINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMF-GVGFIIGPVLG-GLLGDYWLRL 159
Cdd:PRK09874 299 VLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFrDIGNVTGPLMGaAISANYGFRA 378
                        170       180
                 ....*....|....*....|....*.
gi 217502434 160 PFIAAAVLNACNFLLALFILPESRTP 185
Cdd:PRK09874 379 VFLVTAGVVLFNAVYSWNSLRRRRIP 404
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
39-156 5.81e-05

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 44.93  E-value: 5.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  39 IAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ---LWMLLLGRAIAGLTSA--NVSV 113
Cdd:cd06177  232 IVKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPspgVWMLVLSIILHGVCYDffFVTG 311
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 217502434 114 ATaYITDISPEDKRAGRFGLFNAM-FGVGFIIGPVLGGLLGDYW 156
Cdd:cd06177  312 YI-YVDKKAPKDIRASAQGLFMLMtNGVGALVGSILSGKVVDKF 354
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
50-177 9.49e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.54  E-value: 9.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  50 YGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAG 129
Cdd:cd06179   41 WSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGL 120
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 217502434 130 RFGLFNAMFGVGFIIGPVLGGLL---GDYWLRLPFIAAAVLNACNFLLALF 177
Cdd:cd06179  121 VQGVVNLVASPGSALGPLIAGALveaNAAGWRWIFYINAIFNALALILLFF 171
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
70-349 1.05e-04

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 44.14  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  70 RRPVLLISLAGAAINYVLLAFAP---QLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRagrfGLFNAMFGVGFIIG 145
Cdd:cd17485   65 RRSWLLPTQLGLALLLLALAFLPpttNLLAFLGLLFLLNLFSATQDIATdGLAVELLTPEER----GLGNAAQVVGYKLG 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 146 PVLGG-----LLGDYWLRLPFIAAAVLNACNFLLALFiLPESRTPGRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFIL 220
Cdd:cd17485  141 SLLGGggllwLYDLIGWQSLLLSLAALYLLLLLPVLF-LRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLY 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 221 SAtgeayGVCWALWGFDTF----QWNGFWIGLSLGAFGVCQTLVQALLPGPATKLLGERRA-----VLVGIACACIALVA 291
Cdd:cd17485  220 KL-----GEQGALAMLPPFlvdrGFSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLlllggLLRLLLLGLYTLLA 294
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 292 MAFAKQGWIVFAIMPIF--ALGSIGTPALQALATRQVDEARQGQFQGVLASAVSLASIVA 349
Cdd:cd17485  295 LGGSGLNWVLLLASLALlhLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLF 354
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
44-179 1.22e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 43.77  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANV-SVATAYITDIS 122
Cdd:cd17313  284 AWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATInINPYPLVSDYH 363
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434 123 PEDKR--AGRFGLFNAMFGVGFIIGPVLGGLLGDYWLRLPFIAAAvlnACNFLLALFIL 179
Cdd:cd17313  364 SESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVA---AVASFLSLVGA 419
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
64-157 1.58e-04

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 43.67  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  64 LSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAI----AGLTSANVSVataYITDISPEDKRAGRFGLFNAMFG 139
Cdd:cd17434   64 LNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLtgfaGGITAASIPV---YVSEISHPGVRGALGACPQIMAV 140
                         90
                 ....*....|....*...
gi 217502434 140 VGFIIGPVLGGLLGDYWL 157
Cdd:cd17434  141 FGSLALYALGLLLPWRWL 158
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
237-397 1.92e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 237 DTFQWNGFWIGLSLGAFGVCQTLVQALLpGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALGS-IGT 315
Cdd:COG2814   38 ADLGASPAQAGLVVTAYLLGAALGAPLA-GRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAgALF 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 316 PALQALATRQVDEARQGQFQGVLASAVSLASIVAPLAfstFYFVVQAEWPGAIWLAVVVIYSMAVPLVLLGTRTARPARP 395
Cdd:COG2814  117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL---GGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR 193

                 ..
gi 217502434 396 AS 397
Cdd:COG2814  194 AR 195
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
22-384 2.67e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  22 IFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRR-PVLLISLAGAAINYVLLAFAPQLWMLLLG 100
Cdd:cd17370   18 ARSILPLFLVVLGAS---AAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 101 RAIAGLTSANVSVAT-AYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW---LRLPFIAAAVLNACNFLLAL 176
Cdd:cd17370   95 RILERLGKGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLggnYRTIFLLAAIPALLALLILL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 177 FILPESRTPGRQKidlaalNPLRPLRWVLSMKGLLPIIFVFFILSATGEAYGVcwALWGFDTFQWNGFWIGLSLGAFGVC 256
Cdd:cd17370  175 FVVKEYPRPPKLR------KKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAF--LILRAQELGLSAALIPLLYALFNLV 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 257 QTLVqALLPGPATKLLGERRAVLVGIACACIALVAMAFAKQGWIVFAIMPIFALG-SIGTPALQALATRQVDEARQGQFQ 335
Cdd:cd17370  247 YALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAY 325
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 217502434 336 GVLASAVSLASIVAPLAFSTFYfvvQAEWPGAIWLAVVVIYSMAVPLVL 384
Cdd:cd17370  326 GLFNTVVGIGWLLASLIAGYLW---DLISPSAAFLFSAVLALIALLLLL 371
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
22-189 3.03e-04

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 42.68  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  22 IFPILPRLL-EDVTrtqniapyIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLG 100
Cdd:cd17383   18 IVPIIPDYLnEDIA--------IGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 101 RAIAGLTSANVSVA-TAYITD-ISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALF 177
Cdd:cd17383   90 RSLQGVGSAFADTAgLAMIADrFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAgKEVPFLILAFVCLLDGLLLLL 169
                        170
                 ....*....|..
gi 217502434 178 ILPESRTPGRQK 189
Cdd:cd17383  170 VMKPVRRETRAN 181
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
44-178 3.51e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 42.26  E-value: 3.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIA-GLTSANVSVATAYITDIS 122
Cdd:cd17355  248 AVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAARY 327
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 123 PEDKRAGR-FGLFNAMFGVGFIIGPVLGGLL----GDYwlRLPFIAAAVLNACNFLLALFI 178
Cdd:cd17355  328 FGARSYGTlFGLVFAPHQLGSALGPWLGGLLydrtGSY--TAAWALAVALGLIAALLVLPI 386
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
60-182 5.13e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 41.95  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMF 138
Cdd:cd17362   58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVgIGLAMHAAPVYIAETSPSHIRGLLVSLKELFI 137
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 217502434 139 GVGFIIGPVLGGLLGD--YWLRLPFIAAAVLnACNFLLALFILPES 182
Cdd:cd17362  138 VLGILLGYVSGYAFADvvGGWRYMYGLAAPP-ALLLGIGMWFLPPS 182
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
45-178 6.12e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 6.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  45 IMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ-LWMLLLGRAIAGLT-SANVSVATAYITDIS 122
Cdd:cd17353  253 LAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFCyGGGFALFPALTADFF 332
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434 123 PEDKRAGRFGLFNAMFGVGFIIGPVLGG-LLGDYWLRLPFIAAAVLNACNFLLALFI 178
Cdd:cd17353  333 GTKNAGTNYGLLYTAKGVGGLIGPIIAAyVLYTGGYNAAFIIAAALSLVALALALLL 389
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
1-152 6.81e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.57  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434    1 MNRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQNIAPYIGIMIALYGIMQFIFApvlGALSDNLGRRPVLLISLAG 80
Cdd:TIGR00895 248 TARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIF---GWLADRLGPRVTALLLLLG 324
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 217502434   81 AAINYVLLAFAPQLWMLLLGRAIAGL-TSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL 152
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIAGFfVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
47-167 7.47e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 7.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  47 IALYGIMQFIFA-------PVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYIT 119
Cdd:cd17478  229 LVFAGLLLSLFLfagaigtLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 217502434 120 DISPEdKRAGRFGLFNA-MFGVGFIIGPVLgGLLGDYW-LRLPFIAAAVL 167
Cdd:cd17478  309 ELLPG-NVGLASGLMMGlSFGLGGIGAPVL-GALADAFgLESVLLILALL 356
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
62-182 9.94e-04

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 41.08  E-value: 9.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  62 GALSDNLGRRPVLLIS----LAGAAINyvllAFAPQLWMLLLGRAIAGLTSA-NVSVATAYITDISPEDKRAGRFGLFNA 136
Cdd:cd17361   72 SYVTRKWGRKPSMLIGgvlfLVGAALN----AAAQNIAMLIVGRILLGFGVGfGNQAVPLYLSEMAPAKLRGALNIGFQL 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 217502434 137 MFGVGFIIGPVLG---GLLGDYWLRLPFIAAAVLNACNFLLALFiLPES 182
Cdd:cd17361  148 AITIGILIANLINygtSKIKPNGWRLSLGLAAVPALILLLGSLF-LPET 195
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
54-115 1.04e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.74  E-value: 1.04e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434  54 QFIF-------APVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT 115
Cdd:cd17374   41 QSIFmagllvgALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINT 109
MFS_CynX_like cd17410
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ...
40-167 1.08e-03

Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340968 [Multi-domain]  Cd Length: 372  Bit Score: 40.86  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  40 APYIGIMIALYGIMQFIFAPVLGALSD-NLGRRPVLLISLAGAAINYVLLAFAPQ----LWMLLLGRAIAGLTSANVSVA 114
Cdd:cd17410  228 AQDSGSLLGFMTIFQVLGALVMPALARrSADRRPLLMGALAAQLAGFLGLILMPQslplLWVALIGLGLGACFSLGLILA 307
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217502434 115 tayiTDISPEDKRAGRFGLFnaMFGVGFIIGPV-----------LGGLLGDYWLRLPFIAAAVL 167
Cdd:cd17410  308 ----LDHLRKPRAAGQLAAF--VQGIGFIITGIspwiagwlrdsTGSFQAAWLLLAASVVAMLL 365
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
43-182 1.09e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 40.70  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFA-PQLWMLLLGRAIAGLTSANVSVATA-YITD 120
Cdd:cd17356   47 QGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPvYQSE 126
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434 121 ISPEDKRAGRFGLFNAM--FG--VGFIIGPVLGGLLGDYWLRLPF---IAAAVLnacnFLLALFILPES 182
Cdd:cd17356  127 VAPKHIRGTLVSLYQLAitIGilVAYCINYGTHKLDGSAQWRIPLglqIVWGLL----LLIGMFFLPES 191
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
55-348 1.11e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 40.89  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   55 FIFAPVLGALSDNLGRRPVLLIS---LAGAAINYVLLAFAPQL--WMLLLGRAIAGL-TSANVSVATAYITDISPEDKRA 128
Cdd:pfam05977  59 FLLSIPAGALADNFDRRKIMLAGqllLALVSTLLTLLAGLGLLspWLLLGLTFLGGIgTALMDPAWQASVPELVPRRDLP 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  129 GRFGLFNAMFGVGFIIGPVLGGLLgdywlrLPFIAAAVLNACNFLLALFIL----------PESRTPgRQKIDLAALNPL 198
Cdd:pfam05977 139 AAVALNSVGYNIARSVGPALGGVL------LAAFGPAFTFALNALSYFAVIaalwrwkraaPASPLP-RERIFGAVRAGL 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  199 RPLRWVLSMKGLLPIIFVFFILSATGeaygvcWALWGF---DTFQWNGFWIGLSLGAFGVCQTLVQALLPGPATKLLGER 275
Cdd:pfam05977 212 RFTAMSRELRSVLVRAFAFGLSASAV------WALLPLvarDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDR 285
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217502434  276 RAVLVGIACACIALVaMAFAKQGWIVFAIMP------IFALGSIGTpALQALATRQVDEARQGQFQGVLASAVSLASIV 348
Cdd:pfam05977 286 LVLLASVVTALVLLS-LALAPNLWLAIPVLLlggaawITALTTLNV-AVQLSVPRWVRGRALAVYQTVFFGGMAAGSWL 362
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
64-184 1.56e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 40.73  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   64 LSDNLGRRPVLLISLAGAAINYVLLAFA-PQLWMLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAMFGVGF 142
Cdd:TIGR01299 618 LMDKIGRLRMLAGSMVLSCISCFFLSFGnSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAA 697
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 217502434  143 IIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALfILPESRT 184
Cdd:TIGR01299 698 VLGILIFGSFVGITKAAPILFASAALACGGLLAL-KLPDTRG 738
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
60-183 1.63e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 40.55  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVATAYIT-DISPEDKRAGRFGLFNAMF 138
Cdd:cd17363  351 VSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSIAAWNALDVVTvELYPTDKRATAFGFLNGLC 430
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 217502434 139 GVGFIIGPVLGGLLGDYWLRLPFIAAAVLNACNFLLALfILPESR 183
Cdd:cd17363  431 KLAAILGNSIFGSFVGITKVIPILLASAALVCGGLLAL-KLPETR 474
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
55-180 1.78e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 40.03  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  55 FIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVAT-AYITDISPEDKRAGRFGL 133
Cdd:cd17379   47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGyVLVTEFVGSKYRRTVGIV 126
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 217502434 134 FNAMFGVGFIIGPVLGGLLGDY-WLRLpfiaAAVLNACNFLLALFILP 180
Cdd:cd17379  127 YQMFFTLGLLILPGIAYFIPHWrWLQL----AVTLPNFLFLLYYWFIP 170
PRK12382 PRK12382
putative transporter; Provisional
60-179 1.79e-03

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 40.04  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANV--SVATAYITDISPEDkRAGRFGLFNAM 137
Cdd:PRK12382 268 LFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIfpALGVEVVKRVPSQV-RGTALGGYAAF 346
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 217502434 138 FGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFIL 179
Cdd:PRK12382 347 QDIAYGVSGPLAGMLATSFgYPSVFLAGAISAVLGIIVTILSF 389
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
2-152 1.88e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   2 NRPLLVIYATIGLDAVGIGLIFPILPRLLEDVTRTQ--NIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLA 79
Cdd:cd17504  176 RRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGfgLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 217502434  80 GAAINYVLLAFAPQ-LWMLLLGRAIAGLTSANVSVATAYITDIS-PEDKRAGRFGLFNAMFGVGFIIGPVLGGLL 152
Cdd:cd17504  256 ISAVGLLLLALLHSsLWALVVALLLIGIGLGLAFASLPNIVVESvPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
48-176 2.07e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.98  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  48 ALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLT-SANVSVATAYITDISPEDk 126
Cdd:cd06180  238 SLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTfMAITALVMALARELAPPA- 316
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 217502434 127 RAGRFGLFNAMFGVGFIIGPVLGGLLGDYW--LRLPFIAAAVLNACNFLLAL 176
Cdd:cd06180  317 APRALALMTASFGVGQILGPLLAGWLADATggFAPALILAAAALVVAALLAL 368
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
43-180 2.07e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 39.89  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  43 IGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISL---AGAAINYVLLAFAPQ----LWMLLLGRAIAGLTSANVSVAT 115
Cdd:cd17385   36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMfvsGGCTILFGFLDRVPDgtvfIALCFLVRIVEAVGFAAFITAS 115
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217502434 116 -AYITDISPeDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILP 180
Cdd:cd17385  116 fAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQAGgYELPFLVLGCLLLLTVPLNMFILP 181
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
73-180 2.63e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.52  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  73 VLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGL 151
Cdd:cd17390  242 LLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCsTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGL 321
                         90       100
                 ....*....|....*....|....*....
gi 217502434 152 LGDYWLRLPFIAAAVLNACNFLLALFILP 180
Cdd:cd17390  322 LQEFSVSGPGLLGAVLALAAILLMLARQR 350
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
1-200 2.77e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 39.73  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434    1 MNRPL---LVIYATIGLDAVGIGLIFPILPRLLEDvtrtqNIAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLIS 77
Cdd:pfam05977 216 MSRELrsvLVRAFAFGLSASAVWALLPLVARDLLD-----GDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLA 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   78 LAGAAINYVLLAFAPQLW-----MLLLGRA-IAGLTSANVSVATayitdISPEDKRAGRFGLFNAMFGVGFIIGPVLGGL 151
Cdd:pfam05977 291 SVVTALVLLSLALAPNLWlaipvLLLGGAAwITALTTLNVAVQL-----SVPRWVRGRALAVYQTVFFGGMAAGSWLWGA 365
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 217502434  152 LGDYwLRLPFiaAAVLNACNFLLALFILPESRTPGRQKIDLAALNPLRP 200
Cdd:pfam05977 366 VAEA-LSVTG--ALLGAAAALLAGAAAGLRFRLPEGEAADLIPSNHWPE 411
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
44-152 3.61e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ---LWMLLLGRAIAGL-TSANVSVATAYIT 119
Cdd:cd17321  207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLgLGLFATPLTNAAL 286
                         90       100       110
                 ....*....|....*....|....*....|...
gi 217502434 120 DISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLL 152
Cdd:cd17321  287 SSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
42-211 3.70e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.16  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  42 YIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSANVSVA-TAYITD 120
Cdd:cd17393   35 ALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAmNAQGVA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 121 IspeDKRAGR--FGLFNAMFGVGFIIGPVLGGLLGdyWLRLP----FIAAAVLNACNFLLAL-FILPESRTPGRQKIDLA 193
Cdd:cd17393  115 V---ERAYGRpiMSSLHAMWSLGGLAGALLGAAAI--GAGVSpgvhLLAAAVLLLLAALVAIrALLPGTGEAAEDRPDGA 189
                        170
                 ....*....|....*...
gi 217502434 194 ALNPLRPLRWVLSMKGLL 211
Cdd:cd17393  190 GKPGFLLPNRLLLLLGLL 207
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
18-223 5.55e-03

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 38.38  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   18 GIGLIFPILPRLLEDvtrtQNIAPY-IGIMIALYGIMQFIFAPVLGALSDNLGRR-PVLLISLAGAAINYVLLAFAP--- 92
Cdd:pfam12832  14 ALGCLLPYWGLYLRS----IGLNPSeIGLITAILPLTRILAPPIWGWLADRTGKRkAVVRLASILAAVLFLSVLFIPisl 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434   93 QLWMLLLGRAIAG--LTSANVSVATAYITDISPEDKRAGRFGLFNAmfgVGFIIGPVLGGLLGDYW--LRLPFIAAAVLN 168
Cdd:pfam12832  90 TFWWLALLVVLFSffWNAILPQFEVATLQHLGEKRKDYGRQRLWGS---VGFALSVFGLGALFDHYsvGLLPSVLFYLFA 166
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 217502434  169 AcnFLLALFILPESRtpgRQKIDLAALNPLRPLRWVLSMKGLLPIIFVFFILSAT 223
Cdd:pfam12832 167 A--LMLLSLLLPLAP---PEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFS 216
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
40-137 6.27e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 38.51  E-value: 6.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  40 APYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAIN----YVLLAFAPQLWMLLLGRAIAGLTSANVSVAT 115
Cdd:cd17368  257 ARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTlypvFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAM 336
                         90       100
                 ....*....|....*....|...
gi 217502434 116 -AYITDISPEDKRAGRFGLFNAM 137
Cdd:cd17368  337 vVALVELFPVRVRSTGFSLVYAL 359
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
15-127 6.77e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 38.37  E-value: 6.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  15 DAVGIGLIFPILPRLLEDVTRTQNIAPYIGIMIALyGIMQFIFapVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQL 94
Cdd:cd17438   11 DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYL-GMMAGAF--IWGGLADKLGRKRCLIISLAINASFAFLSSFVQGY 87
                         90       100       110
                 ....*....|....*....|....*....|....
gi 217502434  95 WMLLLGRAIAGL-TSANVSVATAYITDISPEDKR 127
Cdd:cd17438   88 GAFLFCRLISGFgIGGSLPIVFAYFSEFLAREKR 121
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
22-180 7.97e-03

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 38.15  E-value: 7.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  22 IFPILPRLLEDVTRTqniAPYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGR 101
Cdd:PRK10091  22 IMGVLTELAHDVGIS---IPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434 102 AIAGLT-SANVSVATAYITDISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLG-DYWLRLPFIAAAVLNACNFLLALFIL 179
Cdd:PRK10091  99 LVSGFPhGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSqEFSWRYTFLLIAVFNIAVLASIYFWV 178

                 .
gi 217502434 180 P 180
Cdd:PRK10091 179 P 179
PRK03893 PRK03893
putative sialic acid transporter; Provisional
60-109 8.38e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 38.14  E-value: 8.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLWMLLLGRAIAGLTSA 109
Cdd:PRK03893  74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMA 123
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
44-179 8.80e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 37.97  E-value: 8.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  44 GIMIALYGIMQFIF-APVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLW--MLLLGRAIAGLTSANVsVATAYITD 120
Cdd:cd17331  246 GYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWqlLVLLLPLVIGGSVLYT-VITSLLTK 324
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 217502434 121 ISPEDKRAGRFGLFNAMFGVGFIIGPVLGGLLGDY--WLRLPFIAAAVlnacNFLLALFIL 179
Cdd:cd17331  325 AVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAygFPSFGLLGAAI----NGLLTVYLL 381
cynX PRK09705
putative cyanate transporter; Provisional
40-155 8.98e-03

putative cyanate transporter; Provisional


Pssm-ID: 236614 [Multi-domain]  Cd Length: 393  Bit Score: 37.87  E-value: 8.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  40 APYIGIMIALYGIMQFIFAPVLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQ----LWMLLLGRAIAGLTSANVSVAt 115
Cdd:PRK09705 239 AQYSGSLLALMTLGQAAGALLMPAMARHQDRRKLLMLALVLQLVGFCGFIWLPLqlpvLWAMVCGLGLGGAFPLCLLLA- 317
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 217502434 116 ayiTDISPEDKRAGRFGLFnaMFGVGFIIG---PVLGGLLGDY 155
Cdd:PRK09705 318 ---LDHSVQPAIAGKLVAF--MQGIGFIIAglaPWFSGVLRSI 355
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
60-181 9.32e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.05  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217502434  60 VLGALSDNLGRRPVLLISLAGAAINYVLLAFAPQLW--MLLLGRAIAGLTSANVSVATAYITDISPEDKRAGRFGLFNAM 137
Cdd:cd17371  264 AGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtlILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNV 343
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 217502434 138 FGVGFIIGPVLGGLLGDYW-LRLPFIAAAVLNACNFLLALFILPE 181
Cdd:cd17371  344 GRIIGALFPFLVGFLATSGsLGTAIAVFAAVYYIAGLVLALLLPE 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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