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Conserved domains on  [gi|21704248|ref|NP_663595|]
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U3 small nucleolar RNA-interacting protein 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.22e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 4.22e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgaqgQPAGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21704248 377 fWVSSVAALLNTDLVATGSHNARVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSAGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.22e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 4.22e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgaqgQPAGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21704248 377 fWVSSVAALLNTDLVATGSHNARVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSAGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
132-439 5.59e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 5.59e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 132 QAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgaqgqpaGHSSHVLCMAISSDG 211
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 212 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdA 291
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 292 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLH 368
Cdd:COG2319 254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21704248 369 GEPGleqpfWVSSVAALLNTDLVATGSHNARVRLWQCGEGfRQLDPLcdIPLVGFINSLKFSSAGDFLVAG 439
Cdd:COG2319 328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTL--TGHTGAVTSVAFSPDGRTLASG 390
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 198-439 2.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  198 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRKGTH-QLYSTSHDRSVKVW 268
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  269 NAAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 317
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  318 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEqpfwvSSVA 383
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVK-----NFVG 715

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21704248  384 ALLNTDLVATGSHNARVRLWQ-------CGEGFRQLDPLCDIPL---VGFINSLKFSSAGDFLVAG 439
Cdd:PLN00181 716 LSVSDGYIATGSETNEVFVYHkafpmpvLSYKFKTIDPVSGLEVddaSQFISSVCWRGQSSTLVAA 781
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-269 1.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21704248    230 SCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWN 269
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-269 3.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21704248   232 QHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWN 269
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-439 4.22e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 4.22e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgaqgQPAGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 299 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 376
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21704248 377 fWVSSVAALLNTDLVATGSHNARVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSAGDFLVAG 439
Cdd:cd00200 221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-404 2.09e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 2.09e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgaqgqpAGHSSHVLCMAISSDGKYLASGD 218
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL-----------TGHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 298
Cdd:cd00200 113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 299 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 376
Cdd:cd00200 193 LSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTN---- 262

                       250       260
                ....*....|....*....|....*...
gi 21704248 377 fWVSSVAALLNTDLVATGSHNARVRLWQ 404
Cdd:cd00200 263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
132-439 5.59e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 5.59e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 132 QAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgaqgqpaGHSSHVLCMAISSDG 211
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 212 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdA 291
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 292 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLH 368
Cdd:COG2319 254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21704248 369 GEPGleqpfWVSSVAALLNTDLVATGSHNARVRLWQCGEGfRQLDPLcdIPLVGFINSLKFSSAGDFLVAG 439
Cdd:COG2319 328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTL--TGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
139-404 3.33e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 3.33e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgaqgqpaGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-----------GHTGAVRSVAFSPDGKLLASGS 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRE-CC 297
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFSPDgKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 298 VTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGlhgepgleq 375
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--------- 373

                       250       260
                ....*....|....*....|....*....
gi 21704248 376 pfWVSSVAALLNTDLVATGSHNARVRLWQ 404
Cdd:COG2319 374 --AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
90-439 5.01e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.31  E-value: 5.01e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  90 LRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCT 169
Cdd:COG2319  22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 170 IIKWSVETGRKLHviprakkgaqgQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 249
Cdd:COG2319 102 VRLWDLATGLLLR-----------TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 250 RKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRE-CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSI 327
Cdd:COG2319 171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDgKLLASGSADGTVRLWDLATGKLLrTLTGHSGSV 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 328 DCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqpfWVSSVAALLNTDLVATGSHNARVRLWQCG 406
Cdd:COG2319 250 RSVAFsPDGRLLASGSADGTVRLWDLATGELLRT------LTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       330       340       350
                ....*....|....*....|....*....|...
gi 21704248 407 EGfRQLDPLcdIPLVGFINSLKFSSAGDFLVAG 439
Cdd:COG2319 319 TG-KLLRTL--TGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
139-353 2.84e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 2.84e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgaqgqpaGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-----------GHSGSVRSVAFSPDGRLLASGS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 219 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRECCV 298
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKT 344

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21704248 299 TA-GGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLS 353
Cdd:COG2319 345 LAsGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
179-439 1.31e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 1.31e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 179 RKLHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYS 258
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 259 TSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRECCVTA-GGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NE 335
Cdd:COG2319  96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSV-AFSPDGKTLAsGSADGTVRLWDLATGKLLrTLTGHSGAVTSVAFSpDG 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 336 EHMVSGADDGSVALWGLSKKRPLalqreaHGLHGEPGleqpfWVSSVAALLNTDLVATGSHNARVRLWQCGEGfRQLDPL 415
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLL------RTLTGHTG-----AVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTL 242

                       250       260
                ....*....|....*....|....
gi 21704248 416 cdIPLVGFINSLKFSSAGDFLVAG 439
Cdd:COG2319 243 --TGHSGSVRSVAFSPDGRLLASG 264
WD40 COG2319
WD40 repeat [General function prediction only];
206-439 2.59e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 206 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDA 285
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 286 VAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqre 363
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRT--- 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21704248 364 ahgLHGEPGleqpfWVSSVAALLNTDLVATGSHNARVRLWQCGEGfRQLDPLCDIPlvGFINSLKFSSAGDFLVAG 439
Cdd:COG2319 158 ---LTGHSG-----AVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
139-230 5.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 5.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248 139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgaqgqpAGHSSHVLCMAISSDGKYLASGD 218
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-----------TGHTGAVTSVAFSPDGRTLASGS 391

                        90
                ....*....|..
gi 21704248 219 RSKLILIWEAQS 230
Cdd:COG2319 392 ADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 198-439 2.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  198 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRKGTH-QLYSTSHDRSVKVW 268
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  269 NAAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 317
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704248  318 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEqpfwvSSVA 383
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVK-----NFVG 715

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21704248  384 ALLNTDLVATGSHNARVRLWQ-------CGEGFRQLDPLCDIPL---VGFINSLKFSSAGDFLVAG 439
Cdd:PLN00181 716 LSVSDGYIATGSETNEVFVYHkafpmpvLSYKFKTIDPVSGLEVddaSQFISSVCWRGQSSTLVAA 781
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-269 1.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21704248    230 SCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWN 269
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-269 3.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21704248   232 QHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWN 269
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 197-227 1.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.84e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21704248    197 GHSSHVLCMAISSDGKYLASGDRSKLILIWE 227
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
197-227 5.18e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.18e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21704248   197 GHSSHVLCMAISSDGKYLASGDRSKLILIWE 227
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-174 2.04e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21704248    139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWS 174
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
139-174 3.81e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21704248   139 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWS 174
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
276-310 6.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21704248   276 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-311 2.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21704248    274 SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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