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Conserved domains on  [gi|21645060|gb|AAM70782|]
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cytochrome c oxidase subunit II, partial (mitochondrion) [Tersina viridis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX2 super family cl31800
cytochrome c oxidase subunit II; Provisional
 1-25 1.79e-11

cytochrome c oxidase subunit II; Provisional


The actual alignment was detected with superfamily member MTH00117:

Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 54.15  E-value: 1.79e-11
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00117 202 ANHSFMPIVVESVPLKHFENWSSLL 226
 
Name Accession Description Interval E-value
COX2 MTH00117
cytochrome c oxidase subunit II; Provisional
 1-25 1.79e-11

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 54.15  E-value: 1.79e-11
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00117 202 ANHSFMPIVVESVPLKHFENWSSLL 226
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 1-21 5.92e-09

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 46.41  E-value: 5.92e-09
                        10        20
                ....*....|....*....|.
gi 21645060   1 ANHSFMPIVVESTPLANFESW 21
Cdd:cd13912 110 ANHSFMPIVVEAVSLEDFLSW 130
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
1-13 7.42e-03

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 30.07  E-value: 7.42e-03
                          10
                  ....*....|...
gi 21645060     1 ANHSFMPIVVEST 13
Cdd:pfam00116 108 INHSFMPIVIEAV 120
 
Name Accession Description Interval E-value
COX2 MTH00117
cytochrome c oxidase subunit II; Provisional
 1-25 1.79e-11

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 54.15  E-value: 1.79e-11
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00117 202 ANHSFMPIVVESVPLKHFENWSSLL 226
COX2 MTH00129
cytochrome c oxidase subunit II; Provisional
 1-25 1.16e-09

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177187 [Multi-domain]  Cd Length: 230  Bit Score: 49.33  E-value: 1.16e-09
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00129 202 ANHSFMPIVVEAVPLEHFENWSSLM 226
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 1-21 5.92e-09

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 46.41  E-value: 5.92e-09
                        10        20
                ....*....|....*....|.
gi 21645060   1 ANHSFMPIVVESTPLANFESW 21
Cdd:cd13912 110 ANHSFMPIVVEAVSLEDFLSW 130
COX2 MTH00185
cytochrome c oxidase subunit II; Provisional
 1-25 1.19e-08

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164736 [Multi-domain]  Cd Length: 230  Bit Score: 46.80  E-value: 1.19e-08
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00185 202 ANHSFMPIVVEAVPLEHFENWSSLM 226
COX2 MTH00076
cytochrome c oxidase subunit II; Provisional
 1-25 2.42e-08

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164646 [Multi-domain]  Cd Length: 228  Bit Score: 45.93  E-value: 2.42e-08
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00076 202 ANHSFMPIVVEATPLNNFLNWSSSM 226
COX2 MTH00098
cytochrome c oxidase subunit II; Validated
 1-25 4.94e-08

cytochrome c oxidase subunit II; Validated


Pssm-ID: 177160 [Multi-domain]  Cd Length: 227  Bit Score: 45.09  E-value: 4.94e-08
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00098 202 SNHSFMPIVLELVPLKYFEKWSASM 226
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 1-25 1.58e-07

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 43.66  E-value: 1.58e-07
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00154 202 ANHSFMPIVIESVSVNNFINWIKNM 226
COX2 MTH00038
cytochrome c oxidase subunit II; Provisional
 1-23 2.20e-07

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177113 [Multi-domain]  Cd Length: 229  Bit Score: 43.15  E-value: 2.20e-07
                         10        20
                 ....*....|....*....|...
gi 21645060    1 ANHSFMPIVVESTPLANFESWSS 23
Cdd:MTH00038 202 ANHSFMPIVIESVPFNTFENWVS 224
COX2 MTH00140
cytochrome c oxidase subunit II; Provisional
 1-25 5.46e-07

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214430 [Multi-domain]  Cd Length: 228  Bit Score: 42.23  E-value: 5.46e-07
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00140 202 ANHSFMPIVVEAVPLEDFVKWLELM 226
COX2 MTH00168
cytochrome c oxidase subunit II; Provisional
 1-23 2.11e-05

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177223 [Multi-domain]  Cd Length: 225  Bit Score: 37.65  E-value: 2.11e-05
                         10        20
                 ....*....|....*....|...
gi 21645060    1 ANHSFMPIVVESTPLANFESWSS 23
Cdd:MTH00168 202 ANHSFMPIVVEFVPWETFENWVD 224
COX2 MTH00080
cytochrome c oxidase subunit II; Provisional
 1-25 2.23e-05

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177149 [Multi-domain]  Cd Length: 231  Bit Score: 37.68  E-value: 2.23e-05
                         10        20
                 ....*....|....*....|....*
gi 21645060    1 ANHSFMPIVVESTPLANFESWSSLM 25
Cdd:MTH00080 205 ANHSFMPIAVEVTLLDNFKEWCKLL 229
COX2 MTH00051
cytochrome c oxidase subunit II; Provisional
 1-21 3.58e-04

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177126 [Multi-domain]  Cd Length: 234  Bit Score: 34.37  E-value: 3.58e-04
                         10        20
                 ....*....|....*....|.
gi 21645060    1 ANHSFMPIVVESTPLANFESW 21
Cdd:MTH00051 206 ANHSFMPIVIEGVSLDKYINW 226
COX2 MTH00139
cytochrome c oxidase subunit II; Provisional
 1-21 4.59e-04

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214429 [Multi-domain]  Cd Length: 226  Bit Score: 33.92  E-value: 4.59e-04
                         10        20
                 ....*....|....*....|.
gi 21645060    1 ANHSFMPIVVESTPLANFESW 21
Cdd:MTH00139 202 ANHSFMPIVVEAISPKFFLEW 222
COX2 MTH00023
cytochrome c oxidase subunit II; Validated
 1-23 7.15e-04

cytochrome c oxidase subunit II; Validated


Pssm-ID: 214402 [Multi-domain]  Cd Length: 240  Bit Score: 33.57  E-value: 7.15e-04
                         10        20
                 ....*....|....*....|...
gi 21645060    1 ANHSFMPIVVESTPLANFESWSS 23
Cdd:MTH00023 213 ANHSFMPIVIEAVSLDKYINWLL 235
COX2 MTH00027
cytochrome c oxidase subunit II; Provisional
 1-21 1.76e-03

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214405 [Multi-domain]  Cd Length: 262  Bit Score: 32.30  E-value: 1.76e-03
                         10        20
                 ....*....|....*....|.
gi 21645060    1 ANHSFMPIVVESTPLANFESW 21
Cdd:MTH00027 236 ANHSFMPIVVESVSLSKYIDW 256
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
1-13 7.42e-03

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 30.07  E-value: 7.42e-03
                          10
                  ....*....|...
gi 21645060     1 ANHSFMPIVVEST 13
Cdd:pfam00116 108 INHSFMPIVIEAV 120
COX2 MTH00008
cytochrome c oxidase subunit II; Validated
 1-23 8.43e-03

cytochrome c oxidase subunit II; Validated


Pssm-ID: 164584 [Multi-domain]  Cd Length: 228  Bit Score: 30.21  E-value: 8.43e-03
                         10        20
                 ....*....|....*....|...
gi 21645060    1 ANHSFMPIVVESTPLANFESWSS 23
Cdd:MTH00008 202 ANHSFMPIVLEAVDTKSFMKWVS 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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