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Conserved domains on  [gi|215697809|dbj|BAG92002|]
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unnamed protein product [Oryza sativa Japonica Group]

Protein Classification

cyclin( domain architecture ID 15334709)

cyclin is a cell cycle regulator that regulates cyclin dependent kinases (CDKs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 142-288 2.84e-90

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410270  Cd Length: 147  Bit Score: 269.21  E-value: 2.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 142 EEAAPDIDSCDANNSLAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVN 221
Cdd:cd20567    1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215697809 222 IIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20567   81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 293-409 3.95e-68

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410215  Cd Length: 117  Bit Score: 211.78  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLME 372
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLME 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 215697809 373 CSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEP 409
Cdd:cd20511   81 CARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLPP 117
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 142-288 2.84e-90

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 269.21  E-value: 2.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 142 EEAAPDIDSCDANNSLAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVN 221
Cdd:cd20567    1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215697809 222 IIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20567   81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 293-409 3.95e-68

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 211.78  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLME 372
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLME 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 215697809 373 CSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEP 409
Cdd:cd20511   81 CARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLPP 117
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
90-402 8.51e-62

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 206.16  E-value: 8.51e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  90 SERQKRTADSAFhgPADMECTKITSDDLPLPMMSEMDEV-----MGSELKEIEMEDIEEAA---------PDIDSCDANN 155
Cdd:COG5024   96 RARIPRLSECNL--DSILFIQMTLNEDSYEPMIDYILKKdenslSPYELDENQLALDEKQAeskresqswQDLDATDQED 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 156 SLAVVEYVDEIYSFYRRSEgLSCVS-PNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVR 234
Cdd:COG5024  174 PLMVPEYASDIFEYLLKLE-LIDLPnPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 235 KKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFDMSVPTPYCFMRRFLKAAQSDKKLEL 314
Cdd:COG5024  253 EKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRT 332

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 315 MSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfkswNKCCELHTKYS----EEQLMECSKMMVELHQKA-GHGKl 389
Cdd:COG5024  333 PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQ----NQWDRTLIHYSgnytNPDLKPLNESNKENLQNPsVHHD- 407

                        330
                 ....*....|...
gi 215697809 390 tGVHRKYSTFRYG 402
Cdd:COG5024  408 -AIFPKYPSPTFG 419
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 165-291 8.99e-60

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 190.42  E-value: 8.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  165 EIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTA 244
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 215697809  245 MLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFDMS 291
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 293-410 3.89e-46

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 154.70  E-value: 3.89e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  293 PTPYCFMRRFLKAAQS--DKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQL 370
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNS-PEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 215697809  371 MECSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEPA 410
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 200-284 1.48e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.34  E-value: 1.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809   200 DWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDraYTRTDILEME 279
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 215697809   280 RMIVN 284
Cdd:smart00385  79 RLLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 298-379 1.53e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809   298 FMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINgFKSWNKCCELHTKY-SEEQLMECSKM 376
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEE-TPPWTKELVHYTGYfTEEEILRMERL 80


                   ...
gi 215697809   377 MVE 379
Cdd:smart00385  81 LLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 142-288 2.84e-90

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 269.21  E-value: 2.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 142 EEAAPDIDSCDANNSLAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVN 221
Cdd:cd20567    1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215697809 222 IIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20567   81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 159-288 2.68e-71

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 220.09  E-value: 2.68e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 159 VVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQ 238
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 215697809 239 LVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20507   81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 293-409 3.95e-68

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 211.78  E-value: 3.95e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLME 372
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLME 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 215697809 373 CSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEP 409
Cdd:cd20511   81 CARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLPP 117
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
90-402 8.51e-62

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 206.16  E-value: 8.51e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  90 SERQKRTADSAFhgPADMECTKITSDDLPLPMMSEMDEV-----MGSELKEIEMEDIEEAA---------PDIDSCDANN 155
Cdd:COG5024   96 RARIPRLSECNL--DSILFIQMTLNEDSYEPMIDYILKKdenslSPYELDENQLALDEKQAeskresqswQDLDATDQED 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 156 SLAVVEYVDEIYSFYRRSEgLSCVS-PNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVR 234
Cdd:COG5024  174 PLMVPEYASDIFEYLLKLE-LIDLPnPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 235 KKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFDMSVPTPYCFMRRFLKAAQSDKKLEL 314
Cdd:COG5024  253 EKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRT 332

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 315 MSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfkswNKCCELHTKYS----EEQLMECSKMMVELHQKA-GHGKl 389
Cdd:COG5024  333 PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQ----NQWDRTLIHYSgnytNPDLKPLNESNKENLQNPsVHHD- 407

                        330
                 ....*....|...
gi 215697809 390 tGVHRKYSTFRYG 402
Cdd:COG5024  408 -AIFPKYPSPTFG 419
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 165-291 8.99e-60

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 190.42  E-value: 8.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  165 EIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTA 244
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 215697809  245 MLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFDMS 291
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 157-288 1.06e-52

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 172.48  E-value: 1.06e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 157 LAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKK 236
Cdd:cd20568    3 LMVAEYVPEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215697809 237 LQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20568   83 LQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 147-289 2.45e-51

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 169.36  E-value: 2.45e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 147 DIDSCDANNSLAVVEYVDEIYSFYRRSEgLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRF 226
Cdd:cd20508    1 DIDEENSDDPFQVSEYAKDIFDYMKERE-EKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLY 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215697809 227 LARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20508   80 LSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 161-288 3.39e-49

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 163.19  E-value: 3.39e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 161 EYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLV 240
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 215697809 241 GVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20504   81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 293-410 3.89e-46

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 154.70  E-value: 3.89e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809  293 PTPYCFMRRFLKAAQS--DKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQL 370
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNS-PEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 215697809  371 MECSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEPA 410
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 161-288 2.09e-44

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 150.78  E-value: 2.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 161 EYVDEIYSFYRRSEGLSCVSPNYMLSQnDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLV 240
Cdd:cd20566    7 DYVKDIYQYLRQLEVQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 215697809 241 GVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20566   86 GVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 162-289 6.45e-44

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 149.87  E-value: 6.45e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 162 YVDEIYSFYRRSEGLSCVSPNYM-LSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLV 240
Cdd:cd20562    8 YATDIYLNLRVAELKRRPLPDYMeKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 215697809 241 GVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20562   88 GVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 161-288 2.76e-39

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 137.32  E-value: 2.76e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 161 EYVDEIYSFYRRSEGLSCVSPNYMLSQnDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLV 240
Cdd:cd20565    3 EYVKDIYAYLRQLEEEQAVRPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 215697809 241 GVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20565   82 GVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 146-289 2.78e-38

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 135.74  E-value: 2.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 146 PDIDSCDANNSLAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDR 225
Cdd:cd20560   20 SEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDR 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215697809 226 FLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20560  100 FLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 159-289 3.86e-38

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 134.42  E-value: 3.86e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 159 VVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQ 238
Cdd:cd20561    1 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215697809 239 LVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20561   81 LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 194-286 8.98e-35

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 123.98  E-value: 8.98e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 194 MRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRT 273
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 215697809 274 DILEMERMIVNTL 286
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 293-383 1.87e-29

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 109.71  E-value: 1.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLME 372
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQE 80

                         90
                 ....*....|.
gi 215697809 373 CSKMMVELHQK 383
Cdd:cd20537   81 CAKELLELLAQ 91
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 293-401 2.11e-29

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 110.42  E-value: 2.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQ---SDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQ 369
Cdd:cd20506    1 PTIKTFLRRFLRAAQasvPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP-HPWNPTLEHYTGYKAAD 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 215697809 370 LMECSKMMVELHQKAGHGKLTGVHRKYSTFRY 401
Cdd:cd20506   80 LKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 164-288 1.30e-26

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 103.55  E-value: 1.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 164 DEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEV--HYKLEllDETLFLTVNIIDRFLARENVVRK-KLQLV 240
Cdd:cd20519    6 EEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVceVYRLH--RETFYLAVDFVDRYLSTQTNVPKtQLQLI 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 215697809 241 GVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20519   84 GITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 195-290 1.44e-26

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 102.40  E-value: 1.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 195 RGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTD 274
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 215697809 275 ILEMERMIVNTLQFDM 290
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 293-397 4.00e-24

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 96.14  E-value: 4.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKsWNKCCELHTKYSEEQLME 372
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPE-WTPTLEHYSTYSEEDLLP 79

                         90       100
                 ....*....|....*....|....*
gi 215697809 373 CSKMMVELHQKAGHGKLTGVHRKYS 397
Cdd:cd20509   80 IVQKMAKLVVKSQTSKYQAVKNKYS 104
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 198-289 3.10e-21

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 87.44  E-value: 3.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 198 LIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEE--VSVPVVEDLILICDRAYTRTDI 275
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWEskARVPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|....
gi 215697809 276 LEMERMIVNTLQFD 289
Cdd:cd20559   82 IQMEMHILNTLNWD 95
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 200-284 1.48e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.34  E-value: 1.48e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809   200 DWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDraYTRTDILEME 279
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 215697809   280 RMIVN 284
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 164-288 1.69e-20

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 86.86  E-value: 1.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 164 DEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLA-RENVVRKKLQLVGV 242
Cdd:cd20579   12 DEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQENVVKTRLQLIGI 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 215697809 243 TAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20579   92 SSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 293-402 1.98e-20

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 85.81  E-value: 1.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYE-MLKFQPSMLAAAAIYTAQCTINgFKSWNKCCELHTKYSEEQLM 371
Cdd:cd20505    1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLG-NEVWPQKLARSTGYSLEDLL 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 215697809 372 ECSKMMVELHQKAGHGKLTGVHRKYSTFRYG 402
Cdd:cd20505   80 PCLRDLHRTFLNAPSSPQQAIREKYKSSKYH 110
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 293-397 2.24e-19

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 83.10  E-value: 2.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCtINGFKSWNKCCELHTKYSEEQLME 372
Cdd:cd20510    1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALK-MKNLGEWTPTLEYYSGYSAEDLLP 79

                         90       100
                 ....*....|....*....|....*
gi 215697809 373 CSKMMVELHQKAGHGKLTGVHRKYS 397
Cdd:cd20510   80 LVRKLNAMLTKPPNKKLKTVRSKYS 104
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 192-286 8.65e-19

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 80.82  E-value: 8.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 192 EKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYT 271
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                         90
                 ....*....|....*
gi 215697809 272 RTDILEMERMIVNTL 286
Cdd:cd20521   81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 182-288 2.06e-18

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 81.05  E-value: 2.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 182 NYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRF-LARENVVRKKLQLVGVTAMLLACKYEEVSVPVVE 260
Cdd:cd20580   30 HFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLH 109

                         90       100
                 ....*....|....*....|....*...
gi 215697809 261 DLILICDRAYTRTDILEMERMIVNTLQF 288
Cdd:cd20580  110 EFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 298-379 1.53e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809   298 FMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINgFKSWNKCCELHTKY-SEEQLMECSKM 376
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEE-TPPWTKELVHYTGYfTEEEILRMERL 80


                   ...
gi 215697809   377 MVE 379
Cdd:smart00385  81 LLE 83
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 187-289 2.21e-16

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 75.80  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 187 QNDINEKMRGILIDWLIEVhYKLELLDETLF-LTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEvSVPV-VEDLIL 264
Cdd:cd20515   48 QTEIQPFMRKMVTTWMLEV-CEEQNCEEEVFpLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKE-TIPLtAEKLCI 125

                         90       100
                 ....*....|....*....|....*
gi 215697809 265 ICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20515  126 YTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 193-288 6.47e-15

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 70.32  E-value: 6.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 193 KMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEV--SVPVVEDL-ILICDRA 269
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLnRYLCNSV 84

                         90
                 ....*....|....*....
gi 215697809 270 YTRTDILEMERMIVNTLQF 288
Cdd:cd20528   85 YSKQEYLQMELLILEFFQW 103
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 164-289 1.11e-14

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 71.16  E-value: 1.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 164 DEIYSFYRRSEGLSCVSPNYM-LSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGV 242
Cdd:cd20573   23 DRVLQTMLKAEETCLPSVSYFkCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGA 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 215697809 243 TAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20573  103 TCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 295-405 1.84e-14

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 69.18  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 295 PYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKsWNkccELHTKYS---EEQLM 371
Cdd:cd20512    2 PMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGD-WN---DNLVHYSgytESQLI 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 215697809 372 ECSKMMVELHQKA-GHGKltGVHRKYSTFRYGCAA 405
Cdd:cd20512   78 PCADIMLEYLVKPiKHHD--AFFKKYSSKKFLKAS 110
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 199-290 6.39e-14

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 67.34  E-value: 6.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 199 IDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKY--EEVSVPVVEDLILICDRAYTRTDIL 276
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                         90
                 ....*....|....
gi 215697809 277 EMERMIVNTLQFDM 290
Cdd:cd20526   86 RMERIILDKLHWDL 99
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 293-401 2.47e-13

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 66.00  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYE-MLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQLM 371
Cdd:cd20564    1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTG-QSWPESLVQKTGYTLESLK 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 215697809 372 ECskmMVELHQ---KAGHGKLTGVHRKYSTFRY 401
Cdd:cd20564   80 PC---LMDLHQtylKAPQHAQQSIREKYKNSKY 109
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 198-280 5.43e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 63.97  E-value: 5.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 198 LIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPvVEDLILICDraYTRTDILE 277
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAKVSG--VSEKELRK 78


                 ...
gi 215697809 278 MER 280
Cdd:cd00043   79 AEK 81
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 172-289 9.88e-13

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 65.40  E-value: 9.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 172 RSEGLSCVspnymlsQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKY 251
Cdd:cd20575   40 RVSYFQCV-------QREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKL 112

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 215697809 252 EEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFD 289
Cdd:cd20575  113 RETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 132-289 1.97e-11

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 61.55  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 132 ELKEIEMEDIEEAAPDIDSCDANNSLAVVEYVDEIY----SFYRrseglsCVspnymlsQNDINEKMRGILIDWLIEVHY 207
Cdd:cd20574    2 ELLCCEVDTIRRALPDPNLLYDDRVLQNLLTIEERYlpqcSYFK------CV-------QKDIQPFMRRMVATWMLEVCE 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 208 KLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQ 287
Cdd:cd20574   69 EQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLK 148


                 ..
gi 215697809 288 FD 289
Cdd:cd20574  149 WN 150
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 293-398 3.99e-11

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 59.90  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKsWNKCCELHTKYSEEQLME 372
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGK-WSLTQQYYTGYTEDDLKP 79

                         90       100
                 ....*....|....*....|....*...
gi 215697809 373 CSKMMVELHQKAGHG--KLTGVHRKYST 398
Cdd:cd20570   80 IMQHMAKNVVKVNEGltKHVAVKNKYAS 107
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 201-350 3.74e-10

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 60.52  E-value: 3.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 201 WLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVpvveDLILICDRAY---------T 271
Cdd:COG5333   51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPR----DISIESFEARdlwseepksS 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 272 RTDILEMERMIVNTLQFDMSVPTPYCFMRRFLKAAQSDKKLEL--MSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTI 349
Cdd:COG5333  127 RERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLlqIAWKIINDALRTDLCLLYPPHIIALAALLIACEVL 206


                 .
gi 215697809 350 N 350
Cdd:COG5333  207 G 207
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 293-377 4.45e-10

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 56.22  E-value: 4.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAA------------QSDKKL-----ELMSFFIiELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSW 355
Cdd:cd20529    1 PTPAHFLEYYLSQGvlfvddhdglpsELLEKVkeyvrKYADFFL-DLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 215697809 356 NKCCELHTKYSEEQLMECSKMM 377
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 214-286 7.08e-10

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 55.60  E-value: 7.08e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215697809 214 ETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKY--EEVSVPVVEDLILICDRAYTRTDILEMERMIVNTL 286
Cdd:cd20583   21 ETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRMEKIILEKL 95
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 293-398 1.17e-09

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 55.67  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQLME 372
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDN-GEWTPTLQHYMSYTEESLLP 79

                         90       100
                 ....*....|....*....|....*...
gi 215697809 373 CSKMMVELHQKAGHG--KLTGVHRKYST 398
Cdd:cd20569   80 VMQHMAKNVVKVNQGltKHMTVKNKYAS 107
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 293-414 5.18e-09

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 54.05  E-value: 5.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYE-MLKFQPSMLAAAAIYTAQCTINGfKSWNKCCELHTKYSEEQLM 371
Cdd:cd20563    1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNK-VFWPETLAAFTGYSLSEIV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 215697809 372 ECSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEPAVFLL 414
Cdd:cd20563   80 PCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLP 122
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 214-286 5.20e-09

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 53.13  E-value: 5.20e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215697809 214 ETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKY--EEVSVPVVEDLILICDRAYTRTDILEMERMIVNTL 286
Cdd:cd20523   20 ETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIILEKL 94
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 318-409 3.87e-08

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 51.09  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 318 FIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLMECskmMVELHQKAGH---------GK 388
Cdd:cd20522    5 YICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSC---VLHLHKKCFHedspkdyrnVS 81

                         90       100
                 ....*....|....*....|.
gi 215697809 389 LTGVHRKYSTFRYGCAAKSEP 409
Cdd:cd20522   82 LTAVKQRYEDERFLSISKIKV 102
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 214-286 4.56e-08

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 50.62  E-value: 4.56e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215697809 214 ETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKY--EEVSVPVVEDLILICDRAYTRTDILEMERMIVNTL 286
Cdd:cd20584   21 ETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 195-287 1.50e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 49.24  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 195 RGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKK---LQLVGVTAMLLACKYEEVSVPVVEDLILICDRA-Y 270
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYvF 81

                         90
                 ....*....|....*..
gi 215697809 271 TRTDILEMERMIVNTLQ 287
Cdd:cd20543   82 EAKTIQRMELLVLSTLE 98
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 294-377 4.36e-07

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 47.69  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 294 TPYCFMRRFL-KAAQSDKKLELMSFF--IIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCE--LHTKYSEE 368
Cdd:cd20544    2 TPFSFLDYFIsKIGLSDSREELLSRAteLLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRlsLLLSPNKE 81


                 ....*....
gi 215697809 369 QLMECSKMM 377
Cdd:cd20544   82 KVKKCYELM 90
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 194-288 4.46e-07

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 47.94  E-value: 4.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 194 MRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRT 273
Cdd:cd20517    5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTNL 84

                         90
                 ....*....|....*
gi 215697809 274 DILEMERMIVNTLQF 288
Cdd:cd20517   85 ELINQEKDILEALKW 99
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 293-383 1.86e-05

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 43.27  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 293 PTPYCFMRRFLK-------AAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSW---NKCCEL- 361
Cdd:cd20721    1 PTILTFLRMYIErlslesgAAHASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAWaaeALSAELa 80

                         90       100
                 ....*....|....*....|....
gi 215697809 362 --HTKYSEEQLMECSKMMVELHQK 383
Cdd:cd20721   81 avLVHTRAPEVLRCVQALHQLVGQ 104
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 278-377 6.96e-04

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 38.80  E-value: 6.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 278 MERMIVNTLQFDMSVPTPY-CFMR-RFLKAAQsdkklelmsffIIELSLVEYEMLKFQPSMLAAAAIYtaqCTINGFKSW 355
Cdd:cd20520   12 LQLAQLNPPPKENDSAFLLpQYSLdRFVRAAQ-----------LLDLCILDIGSLQFSYSVLAASALY---LVSPDDEAI 77

                         90       100
                 ....*....|....*....|..
gi 215697809 356 NKCcelhTKYSEEQLMECSKMM 377
Cdd:cd20520   78 EQV----TGYSWEQLAPCVEWM 95
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 294-375 1.69e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 37.00  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215697809 294 TPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAqCTINGFKSWNKCCELHTKYSEEQLMEC 373
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLA-CKLEELPRTLKEIAKVSGVSEKELRKA 79


                 ..
gi 215697809 374 SK 375
Cdd:cd00043   80 EK 81
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 225-279 4.86e-03

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 4.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215697809 225 RFLARENVVRKKLQLVGVTAMLLACKYEEvsVPVVEDLILICDRA----------YTRTDILEME 279
Cdd:cd20513   32 RFYARNSFKDIDPRLVAPTCLYLASKVEE--CPSHARLIVAEAKVlktkfsyefpYRVNDILECE 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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