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Conserved domains on  [gi|215510509|gb|EEC19962|]
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salivary gland metalloprotease, putative [Ixodes scapularis]

Protein Classification

zinc metalloprotease( domain architecture ID 1881)

zinc metalloprotease may be a member of the astacin-like protease family or the adamalysin/reprolysin-like protease family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 176-393 4.99e-70

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04272:

Pssm-ID: 469599  Cd Length: 220  Bit Score: 220.69  E-value: 4.99e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 176 YPSLYQMIDeRKVSALRQNVLHIKAYFAVI--KANLRYASFVFPKVQLRITGITMNKkvsvNPAFsKLYEHPIRHEFSEA 253
Cdd:cd04272    2 YPELFVVVD-YDHQSEFFSNEQLIRYLAVMvnAANLRYRDLKSPRIRLLLVGITISK----DPDF-EPYIHPINYGYIDA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 254 PYSVLLciritplllstccFILFYTLKN-------IVIASIYLNFQW-----------YAYLGTACSEWKVGMSEDRPTS 315
Cdd:cd04272   76 AETLEN-------------FNEYVKKKRdyfnpdvVFLVTGLDMSTYsggslqtgtggYAYVGGACTENRVAMGEDTPGS 142

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215510509 316 YYGAYVFAHELGHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDQRQYQFSYCCQREVRNLYNRPEFKCLR 393
Cdd:cd04272  143 YYGVYTMTHELAHLLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-393 4.99e-70

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 220.69  E-value: 4.99e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 176 YPSLYQMIDeRKVSALRQNVLHIKAYFAVI--KANLRYASFVFPKVQLRITGITMNKkvsvNPAFsKLYEHPIRHEFSEA 253
Cdd:cd04272    2 YPELFVVVD-YDHQSEFFSNEQLIRYLAVMvnAANLRYRDLKSPRIRLLLVGITISK----DPDF-EPYIHPINYGYIDA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 254 PYSVLLciritplllstccFILFYTLKN-------IVIASIYLNFQW-----------YAYLGTACSEWKVGMSEDRPTS 315
Cdd:cd04272   76 AETLEN-------------FNEYVKKKRdyfnpdvVFLVTGLDMSTYsggslqtgtggYAYVGGACTENRVAMGEDTPGS 142

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215510509 316 YYGAYVFAHELGHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDQRQYQFSYCCQREVRNLYNRPEFKCLR 393
Cdd:cd04272  143 YYGVYTMTHELAHLLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
293-362 3.13e-10

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 59.35  E-value: 3.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215510509  293 WYAYLGTACSE-------WKVGMSEDRPTSYYGAYVFAHELGHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSY 362
Cdd:pfam13688 105 GLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAHEIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
 
Name Accession Description Interval E-value
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 176-393 4.99e-70

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 220.69  E-value: 4.99e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 176 YPSLYQMIDeRKVSALRQNVLHIKAYFAVI--KANLRYASFVFPKVQLRITGITMNKkvsvNPAFsKLYEHPIRHEFSEA 253
Cdd:cd04272    2 YPELFVVVD-YDHQSEFFSNEQLIRYLAVMvnAANLRYRDLKSPRIRLLLVGITISK----DPDF-EPYIHPINYGYIDA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 254 PYSVLLciritplllstccFILFYTLKN-------IVIASIYLNFQW-----------YAYLGTACSEWKVGMSEDRPTS 315
Cdd:cd04272   76 AETLEN-------------FNEYVKKKRdyfnpdvVFLVTGLDMSTYsggslqtgtggYAYVGGACTENRVAMGEDTPGS 142

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215510509 316 YYGAYVFAHELGHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSYKMQDQRQYQFSYCCQREVRNLYNRPEFKCLR 393
Cdd:cd04272  143 YYGVYTMTHELAHLLGAPHDGSPPPSWVKGHPGSLDCPWDDGYIMSYVVNGERQYRFSQCSQRQIRNVFRRLGASCLH 220
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 294-385 6.33e-14

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 70.14  E-value: 6.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 294 YAYLGTAC-SEWKVGMSEDRPTSYYGAYVFAHELGHNLGCQHDGDGPSdwvkghigSADCPWDDGYLMSYKMQDQRQYQF 372
Cdd:cd04267  108 LAYVGSMCnPYSSVGVVEDTGFTLLTALTMAHELGHNLGAEHDGGDEL--------AFECDGGGNYIMAPVDSGLNSYRF 179

                         90
                 ....*....|...
gi 215510509 373 SYCCQREVRNLYN 385
Cdd:cd04267  180 SQCSIGSIREFLD 192
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
293-362 3.13e-10

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 59.35  E-value: 3.13e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215510509  293 WYAYLGTACSE-------WKVGMSEDRPTSYYGAYVFAHELGHNLGCQHDGDGPSDWVKGHIGSADCPWDDGYLMSY 362
Cdd:pfam13688 105 GLAWLGQLCNSgsagsvsTRVSGNNVVVSTATEWQVFAHEIGHNFGAVHDCDSSTSSQCCPPSNSTCPAGGRYIMNP 181
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 294-393 4.52e-09

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 56.09  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 294 YAYLGTACS-EWKVGMSEDRPTSyyGAYVFAHELGHNLGCQHDGDGPSdwvkghigsadCP--WDDGYLMSYKMQ-DQRQ 369
Cdd:cd04273  117 LAPVGGMCSpSRSCSINEDTGLS--SAFTIAHELGHVLGMPHDGDGNS-----------CGpeGKDGHIMSPTLGaNTGP 183

                         90       100
                 ....*....|....*....|....
gi 215510509 370 YQFSYCCQREVRNLYNRPEFKCLR 393
Cdd:cd04273  184 FTWSKCSRRYLTSFLDTGDGNCLL 207
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 294-384 7.26e-09

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 54.84  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 294 YAYLGTACSEWKVGMSEDRPTS--YYGAYVFAHELGHNLGCQHDGDG--PSDWVKGHIGSADCPWDDGYLMSY---KMQD 366
Cdd:cd00203   70 WAYLGRVCDSLRGVGVLQDNQSgtKEGAQTIAHELGHALGFYHDHDRkdRDDYPTIDDTLNAEDDDYYSVMSYtkgSFSD 149

                         90
                 ....*....|....*...
gi 215510509 367 QRQYQFSYCCQREVRNLY 384
Cdd:cd00203  150 GQRKDFSQCDIDQINKLY 167
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 295-392 9.94e-08

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 51.85  E-value: 9.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 295 AYLGTACS-EWKVGMSEDRPTSYYG-AYVFAHELGHNLGCQHDGdgpsdwvkghiGSADCPwDDGYLMSYKMQDQRqYQF 372
Cdd:cd04269  106 AYVGGMCSpKYSGGVVQDHSRNLLLfAVTMAHELGHNLGMEHDD-----------GGCTCG-RSTCIMAPSPSSLT-DAF 172

                         90       100
                 ....*....|....*....|
gi 215510509 373 SYCCQREVRNLYNRPEFKCL 392
Cdd:cd04269  173 SNCSYEDYQKFLSRGGGQCL 192
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 295-335 1.31e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 44.28  E-value: 1.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 215510509  295 AYLGTACSE-WKVGMSED-RPTSYYGAYVFAHELGHNLGCQHD 335
Cdd:pfam13582  80 AYVGGVCNSgSKFGVNSGsGPVGDTGADTFAHEIGHNFGLNHT 122
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 321-375 1.98e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 45.31  E-value: 1.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 215510509  321 VFAHELGHNLGCQHDGDG---PSDWVKGHIGSADCPWDDGYLMSYkMQDQRQYQFSYC 375
Cdd:pfam13574 127 VVAHEVGHNFGATHDCDGsqyASSGCERNAATSVCSANGSFIMNP-ASKSNNDLFSPC 183
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 295-392 6.50e-05

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 43.83  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509  295 AYLGTACS-EWKVGMSED-RPTSYYGAYVFAHELGHNLGCQHDgdgpsdwvkGHIGSADCPWDDGYLMSYKMQDQRQYQF 372
Cdd:pfam01421 106 AYVGGMCSlEYSGGVNEDhSKNLESFAVTMAHELGHNLGMQHD---------DFNGGCKCPPGGGCIMNPSAGSSFPRKF 176

                          90       100
                  ....*....|....*....|
gi 215510509  373 SYCCQREVRNLYNRPEFKCL 392
Cdd:pfam01421 177 SNCSQEDFEQFLTKQKGACL 196
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 281-362 2.17e-04

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.71  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215510509 281 NIVIASIYLNFQWYAYLGTacsewkvgmsedrptsyYGAYVFAHELGHNLGCQHDGDGPSDWvkGHIGSADCPWDDGYLM 360
Cdd:cd04268   74 EILLARVYLYSSFVEYSGA-----------------RLRNTAEHELGHALGLRHNFAASDRD--DNVDLLAEKGDTSSVM 134


                 ..
gi 215510509 361 SY 362
Cdd:cd04268  135 DY 136
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 295-352 4.39e-03

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 38.56  E-value: 4.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215510509 295 AYLGTACsewKVGMSEDRPTSYYGA----------YVFAHELGHNLGCQHDGDgPSDWVKGHIGSADC 352
Cdd:cd04271  115 AWLGQLC---RTGASDQGNETVAGTnvvvrtsnewQVFAHEIGHTFGAVHDCT-SGTCSDGSVGSQQC 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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