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Conserved domains on  [gi|215401158|ref|YP_002332413|]
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tail length tape measure protein [Staphylococcus phage phiSauS-IPLA35]

Protein Classification

phage tail tape measure protein domain-containing protein( domain architecture ID 13428198)

phage tail tape measure protein domain-containing protein also contains C-terminal M23 family metallopeptidase domain, as well as lytic transglycosylase-like domain found in tail fiber-like proteins that are multi-domain proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tape_meas_TP901 TIGR01760
phage tail tape measure protein, TP901 family, core region; This model represents a reasonably ...
 322-669 9.86e-111

phage tail tape measure protein, TP901 family, core region; This model represents a reasonably well conserved core region of a family of phage tail proteins. The member from phage TP901-1 was characterized as a tail length tape measure protein in that a shortened form of the protein leads to phage with proportionately shorter tails. [Mobile and extrachromosomal element functions, Prophage functions]


:

Pssm-ID: 273790 [Multi-domain]  Cd Length: 350  Bit Score: 357.05  E-value: 9.86e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   322 STPITLGLGAALKTSADFEGQMSRVGAIAQAS-SKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMP 400
Cdd:TIGR01760    1 SAALGGGLVAAVKAAIEFEDAMSGVRAVVDGSrTKEFEDLSNQARDLGDETPFSAAQIAGAMTALARAGISAKDLLGATP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   401 GVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAI 480
Cdd:TIGR01760   81 TALKLAAASDLTAEEAASILAKIMNAFGLTAKDSEKVADVLNYTANNSAATTRDMGDALQYAGPVAKSLGVSLEETAAAT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   481 EVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVG 560
Cdd:TIGR01760  161 AALASAGIEGEIAGTALKAMLSRLAAPTGKAAKALKKLGIQTRDAKGNMKGLLDVLKELQKLTKGMGTEQQAAKLKTIFG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   561 TEAASGFLALIEAGPD-KINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKL 639
Cdd:TIGR01760  241 VEASSALATLLTAGSKlSLAKNAKSLANSNGSAKKEADKMLDTLKGQLKLLQNAVENAFIELGEALLPALRELAQALTKL 320

                          330       340       350
                   ....*....|....*....|....*....|
gi 215401158   640 VDGFTHLPGWVRKASVGLALFGAAIGPAVL 669
Cdd:TIGR01760  321 INAINGLAKGNPQLAVTLAAVAAAILALTA 350
YqbO super family cl34970
Phage-related minor tail protein [Mobilome: prophages, transposons];
301-1121 9.76e-94

Phage-related minor tail protein [Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG5280:

Pssm-ID: 444091 [Multi-domain]  Cd Length: 962  Bit Score: 328.04  E-value: 9.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  301 KKFSSIGDKMTSLGRTMTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAK 380
Cdd:COG5280    35 EKMDRAGKKMKSIGAALTAGVTAALVAAGAAAVKAAADFEKAMSTVQAVTGATGEELEALEQLAKELGATTGESAAEVAE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  381 GMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALK 460
Cdd:COG5280   115 ALGSVAQAGLSGDELIAVTEGALVLAAATGVDLNEAAEIVASAMNAFGLSADEASRVADLLAAGAQAGNTTSDELADALK 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  461 YAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQ 540
Cdd:COG5280   195 EYAPLAAALGFSLEETLAALALLANAGIKGSDAGTALKEFLIRLADPSKTAAEALEELGINVFDASGKLKGLSEILGELA 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  541 DNMKGMTREQKLATVATIVGTEAASGFLALIEAGPDKINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIE 620
Cdd:COG5280   275 KKFAGLGEAARAAVLAAIFGDDAGRAAIALLLFGTDWYAKLTAALKNSAGAADEAAATMQDNLAGALESLKSALEGLAIT 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  621 VGKDLTPMIRAGAEGLTKLVDGFTHLPGWVRKASVGLALFGAAIGPAVLAGGLLIRTVGSAAKGYASLnrriaentilsn 700
Cdd:COG5280   355 IGETLLPALRDAVEALTGLADWFNELSPAVQELIIAIAGLVAALGPLLLILGALITGIGALAGAFGIL------------ 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  701 tnSKAMKSLGLQTLFlgSTTGKTSKGFKGLAGAMMFNLKPINVLKNSAKLAILPFKLLKNGLGLAAKSLFAVSGGARFAG 780
Cdd:COG5280   423 --STALAKAKGALLA--GPIGIVIAAIAALAAALVLLYKNWDTIKEFLTGLWNSIKEAIGGVWDGIKTSVEGLKGAAGAA 498

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  781 valrfLTGPIGATITAITIAYKVFKTAYDRVEWFRNGINGLGETIKFFGGKIIGGAVRKLGEfknylgSIGKSFKEKFSK 860
Cdd:COG5280   499 -----LSAAAGKAIEALAGISVDALKQGVILSGTISMLWGAAGTEVSLKGGAAQDNVSDAAS------SAGDGALAIINS 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  861 DMKDGYKSLSDDDLLKVGVNKFKGFMQTMGTASKKASDTVKVLGKGVSKETEKALEKYVHYSEENSRIMEKVRlNSGQIS 940
Cdd:COG5280   568 AEQAIIGLAAALKTASTSSALQASTKAAAATKAEKTILAIAMATVKGVTSATAALANAAGVILQGAIKNGISG-ALDSAG 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKEQELNQ-KIKELKEK 1019
Cdd:COG5280   647 ATTVAKLAEEEAINEKIVELLKAAANGANKEAVANALLLDAAAKQNINGQEAILEGITAKGVQTDELQDSDaIQAKFQFE 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1020 ALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILV-RMQRNRNAYsIDEASKAIKEAEKARKARKKEVDKQYE 1098
Cdd:COG5280   727 ELSEGAKATINAINGNGVLGGIIADGIKTNSAELKAAANELKgDINRVAAAI-NSLAEAGAEEIKSEAKEAGSDKAITGE 805

                         810       820
                  ....*....|....*....|...
gi 215401158 1099 DDVIAIKNNVNLSKSEKDKLLAI 1121
Cdd:COG5280   806 AGQAALELAVARVNALISRVTKN 828
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 1851-1972 9.39e-44

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


:

Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 155.05  E-value: 9.39e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1851 VGNIISLIQHESGGNAGITQssaLRDINVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQLLAFFNNRYWRSQFnPR 1930
Cdd:cd13402     1 LNALLRQIQTESGGNPNAIN---NWDSNAKAGHPSKGLMQVIPPTFAAYAPPGHGNILNPLDNILAAINYAKARYGS-GF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1931 GGWSPSGPRRYANGGLITKHqLAEVGEGDKQEMVIPLTRRKR 1972
Cdd:cd13402    77 ALAAGGGGGGYANGGIVTKG-LAEVGEGNKPEEVIPLDPAKR 117
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 1691-1812 1.23e-30

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 120.85  E-value: 1.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1691 QRFGRYTGGLNFNGGRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAG 1770
Cdd:COG0739    81 SGFGYRRHPVTGRRRFHKGIDIAAPTGTPVYAAADGTVVFAGWNGGYGNLVIIDHGNGYTTLYAHLSSILVKVGQRVKAG 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1771 QLIGKSGATGNfVRGAHLHFQLMQgshpgNDTAKDPEKWLKS 1812
Cdd:COG0739   161 QVIGYVGNTGR-STGPHLHFEVRV-----NGKPVDPLPFLPA 196
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-280 1.05e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     3 EKVEGMTLELKLDHLGVQEGMKGLKRQLGVVNSEMKAnlsafdkSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV 82
Cdd:TIGR02168  743 EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE-------AEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    83 NANYQKAKSSVKDVEKAylklVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQ----K 158
Cdd:TIGR02168  816 NEEAANLRERLESLERR----IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEealaL 891

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   159 LKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNL--------SKSNDKIESSYAKTNTKLKQTE 230
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLqerlseeySLTLEEAEALENKIEDDEEEAR 971

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158   231 KEFNDLNNTIK-----NHSA-----NVAKAETAVNKEKA----ALNNLERSIDKASSEMK-----TFNK 280
Cdd:TIGR02168  972 RRLKRLENKIKelgpvNLAAieeyeELKERYDFLTAQKEdlteAKETLEEAIEEIDREARerfkdTFDQ 1040
235kDa-fam super family cl31124
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 917-1392 7.15e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


The actual alignment was detected with superfamily member TIGR01612:

Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.12  E-value: 7.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   917 KYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKrNKKELEKTQELIDKY--------SAFDEQEK 988
Cdd:TIGR01612 1457 KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADK-NAKAIEKNKELFEQYkkdvtellNKYSALAI 1535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   989 QNILTRTKEKNDLRIKKeqelnqkIKELKEKALSDGQISENERKEI----------------------------EKLENQ 1040
Cdd:TIGR01612 1536 KNKFAKTKKDSEIIIKE-------IKDAHKKFILEAEKSEQKIKEIkkekfrieddaakndksnkaaidiqlslENFENK 1608

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1041 RRDIT---------VKELSKTEKEQERILVRMQRNR------NAYSIDEASKAIKEAEKARKARKKEVD------KQYED 1099
Cdd:TIGR01612 1609 FLKISdikkkindcLKETESIEKKISSFSIDSQDTElkengdNLNSLQEFLESLKDQKKNIEDKKKELDeldseiEKIEI 1688

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1100 DVIAIKNNVNLSKSEKDKLLAIADqrhKDEVRKAK-SKKDAVVDVVKKQNKD----IDKEMDLSS-----GRVYKNTEKW 1169
Cdd:TIGR01612 1689 DVDQHKKNYEIGIIEKIKEIAIAN---KEEIESIKeLIEPTIENLISSFNTNdlegIDPNEKLEEynteiGDIYEEFIEL 1765

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1170 WNGLkswwSNFREDQKKKSDKYakEQEETARRNREN-------IKKWFGNAWDGVKSKtgeafsKMGRNANHFggemkkm 1242
Cdd:TIGR01612 1766 YNII----AGCLETVSKEPITY--DEIKNTRINAQNeflkiieIEKKSKSYLDDIEAK------EFDRIINHF------- 1826

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1243 wsgikgiPSKLSSGWSSAKSSVGYHTKAIANstgkwFGKAWQSVKSTTG-----SIYNQTKQKYSDASDKAWAHSKSiwr 1317
Cdd:TIGR01612 1827 -------KKKLDHVNDKFTKEYSKINEGFDD-----ISKSIENVKNSTDenllfDILNKTKDAYAGIIGKKYYSYKD--- 1891

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1318 GTSKWFSNAYKSAKGWLTDMANKSRAK-WDNISSTAWSNAKSVWKGTSKWFSNSYKSlkdwtGDMYSRAHDRFDAI 1392
Cdd:TIGR01612 1892 EAEKIFINISKLANSINIQIQNNSGIDlFDNINIAILSSLDSEKEDTLKFIPSPEKE-----PEIYTKIRDSYDTL 1962
 
Name Accession Description Interval E-value
tape_meas_TP901 TIGR01760
phage tail tape measure protein, TP901 family, core region; This model represents a reasonably ...
 322-669 9.86e-111

phage tail tape measure protein, TP901 family, core region; This model represents a reasonably well conserved core region of a family of phage tail proteins. The member from phage TP901-1 was characterized as a tail length tape measure protein in that a shortened form of the protein leads to phage with proportionately shorter tails. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273790 [Multi-domain]  Cd Length: 350  Bit Score: 357.05  E-value: 9.86e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   322 STPITLGLGAALKTSADFEGQMSRVGAIAQAS-SKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMP 400
Cdd:TIGR01760    1 SAALGGGLVAAVKAAIEFEDAMSGVRAVVDGSrTKEFEDLSNQARDLGDETPFSAAQIAGAMTALARAGISAKDLLGATP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   401 GVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAI 480
Cdd:TIGR01760   81 TALKLAAASDLTAEEAASILAKIMNAFGLTAKDSEKVADVLNYTANNSAATTRDMGDALQYAGPVAKSLGVSLEETAAAT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   481 EVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVG 560
Cdd:TIGR01760  161 AALASAGIEGEIAGTALKAMLSRLAAPTGKAAKALKKLGIQTRDAKGNMKGLLDVLKELQKLTKGMGTEQQAAKLKTIFG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   561 TEAASGFLALIEAGPD-KINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKL 639
Cdd:TIGR01760  241 VEASSALATLLTAGSKlSLAKNAKSLANSNGSAKKEADKMLDTLKGQLKLLQNAVENAFIELGEALLPALRELAQALTKL 320

                          330       340       350
                   ....*....|....*....|....*....|
gi 215401158   640 VDGFTHLPGWVRKASVGLALFGAAIGPAVL 669
Cdd:TIGR01760  321 INAINGLAKGNPQLAVTLAAVAAAILALTA 350
YqbO COG5280
Phage-related minor tail protein [Mobilome: prophages, transposons];
301-1121 9.76e-94

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444091 [Multi-domain]  Cd Length: 962  Bit Score: 328.04  E-value: 9.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  301 KKFSSIGDKMTSLGRTMTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAK 380
Cdd:COG5280    35 EKMDRAGKKMKSIGAALTAGVTAALVAAGAAAVKAAADFEKAMSTVQAVTGATGEELEALEQLAKELGATTGESAAEVAE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  381 GMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALK 460
Cdd:COG5280   115 ALGSVAQAGLSGDELIAVTEGALVLAAATGVDLNEAAEIVASAMNAFGLSADEASRVADLLAAGAQAGNTTSDELADALK 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  461 YAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQ 540
Cdd:COG5280   195 EYAPLAAALGFSLEETLAALALLANAGIKGSDAGTALKEFLIRLADPSKTAAEALEELGINVFDASGKLKGLSEILGELA 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  541 DNMKGMTREQKLATVATIVGTEAASGFLALIEAGPDKINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIE 620
Cdd:COG5280   275 KKFAGLGEAARAAVLAAIFGDDAGRAAIALLLFGTDWYAKLTAALKNSAGAADEAAATMQDNLAGALESLKSALEGLAIT 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  621 VGKDLTPMIRAGAEGLTKLVDGFTHLPGWVRKASVGLALFGAAIGPAVLAGGLLIRTVGSAAKGYASLnrriaentilsn 700
Cdd:COG5280   355 IGETLLPALRDAVEALTGLADWFNELSPAVQELIIAIAGLVAALGPLLLILGALITGIGALAGAFGIL------------ 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  701 tnSKAMKSLGLQTLFlgSTTGKTSKGFKGLAGAMMFNLKPINVLKNSAKLAILPFKLLKNGLGLAAKSLFAVSGGARFAG 780
Cdd:COG5280   423 --STALAKAKGALLA--GPIGIVIAAIAALAAALVLLYKNWDTIKEFLTGLWNSIKEAIGGVWDGIKTSVEGLKGAAGAA 498

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  781 valrfLTGPIGATITAITIAYKVFKTAYDRVEWFRNGINGLGETIKFFGGKIIGGAVRKLGEfknylgSIGKSFKEKFSK 860
Cdd:COG5280   499 -----LSAAAGKAIEALAGISVDALKQGVILSGTISMLWGAAGTEVSLKGGAAQDNVSDAAS------SAGDGALAIINS 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  861 DMKDGYKSLSDDDLLKVGVNKFKGFMQTMGTASKKASDTVKVLGKGVSKETEKALEKYVHYSEENSRIMEKVRlNSGQIS 940
Cdd:COG5280   568 AEQAIIGLAAALKTASTSSALQASTKAAAATKAEKTILAIAMATVKGVTSATAALANAAGVILQGAIKNGISG-ALDSAG 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKEQELNQ-KIKELKEK 1019
Cdd:COG5280   647 ATTVAKLAEEEAINEKIVELLKAAANGANKEAVANALLLDAAAKQNINGQEAILEGITAKGVQTDELQDSDaIQAKFQFE 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1020 ALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILV-RMQRNRNAYsIDEASKAIKEAEKARKARKKEVDKQYE 1098
Cdd:COG5280   727 ELSEGAKATINAINGNGVLGGIIADGIKTNSAELKAAANELKgDINRVAAAI-NSLAEAGAEEIKSEAKEAGSDKAITGE 805

                         810       820
                  ....*....|....*....|...
gi 215401158 1099 DDVIAIKNNVNLSKSEKDKLLAI 1121
Cdd:COG5280   806 AGQAALELAVARVNALISRVTKN 828
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
201-889 1.11e-75

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 269.03  E-value: 1.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  201 LKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNK 280
Cdd:COG5283     5 LGAVDKPFKSALESAKQRVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDTRQLSA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  281 EQMIAQSHFGKLASQADVMSKKFSSIGDKMTSLGRT--------MTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQA 352
Cdd:COG5283    85 AQRRLRSSLEQTNRQLERQQQRLARLGARQDRLKAArarlqrlaGAGAAAAAIGAALAASVKPAIDFEDAMADVAATVDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  353 --SSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLK 430
Cdd:COG5283   165 dkSSEQFKALGKQARELSAQTPQSADDIAAGQAALAQAGVSAEDILAFTPTAAKLATAFDTDAEEAAEIAAKILNAFKLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  431 ASDANHVADLLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKN 510
Cdd:COG5283   245 ADDVERLGDALNYAGNNGATSLADLADALPYVGPVAKALGVSGKEAAALGAALADAGIEGEEAGTALRNMLTRLTSPTKA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  511 TAKEMKKLGIHLSDAKGQFVGM------------GELIRQFQDNMKGMTREQKLATVATIVGTEAASGFLALIEAGPD-K 577
Cdd:COG5283   325 AAKALKKLGIDTQDSKGNLRGLakilakqmqkdaQGALAELLKALKKLDAAKRAAALKQLFGEEAVSALAPLLQNGDElR 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  578 INSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKLVDGFTHLPGWVRKASVGL 657
Cdd:COG5283   405 KQLAVAEAAAAQGSMDKEAAKRTDTLAGQLKLLKNALENLGISIGEALLPALRELAQALTPVVGKLADWAKANPGLIKTI 484

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  658 ALFGAAIGPAVLAGGLLIRTVGSAAKGYASLNRRIAentilsntnskamkslglqtLFLGSTTGKTSKGFKGLAgammfn 737
Cdd:COG5283   485 VKVAAALAGLKAALGALRLALALLLSPLAALKAAAA--------------------LLGGGGLGGAGRGAGALA------ 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  738 lkpinvlknsaklailpfkllknGLGlAAKSLFAVSGGARFAGVALrfLTGPIGATITAITI-AYKVFKTaydrveWfrn 816
Cdd:COG5283   539 -----------------------ALG-GAKGLKLAGGAVLWLGRAL--LANPIGLVIAAIAAaAYLIYKY------W--- 583

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  817 ginglgETIKFFGGKIIGGavrklgeFKNYLGSIGKSFKEKFSKDMKDGYKSLSDDDLLKVGVNKFKGFMQTM 889
Cdd:COG5283   584 ------EPIKAFFKGVWEG-------IKAAFSPAWEAIKALISNWLGPVWDGLAIAGAGAGEAAAAAAVAGAQ 643
PhageMin_Tail pfam10145
Phage-related minor tail protein; Members of this family are found in putative phage tail tape ...
 361-560 4.51e-52

Phage-related minor tail protein; Members of this family are found in putative phage tail tape measure proteins.


Pssm-ID: 462962 [Multi-domain]  Cd Length: 201  Bit Score: 182.50  E-value: 4.51e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   361 SNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMPGVISAAEASGA-EMATTATVMASAINSFGLKASDANHVAD 439
Cdd:pfam10145    1 RDAALELGETTGFSATDAAEAMAALASAGLSAEELLSATEGALKLAVAGGAtDAAEAAEALAAAMNAFGLSADDAEEAAD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   440 LLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLG 519
Cdd:pfam10145   81 VLAAAANNGATEVGDLADALKEVGPVAKAAGLSGEETAAALALLAAAGISGSEAGTALKNFLTRLAAPTKEAAKALKKLG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 215401158   520 IHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVG 560
Cdd:pfam10145  161 ISAKDANGKMKSLSEILEELAQALKGLTDAQRAAALSALFG 201
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 1851-1972 9.39e-44

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 155.05  E-value: 9.39e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1851 VGNIISLIQHESGGNAGITQssaLRDINVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQLLAFFNNRYWRSQFnPR 1930
Cdd:cd13402     1 LNALLRQIQTESGGNPNAIN---NWDSNAKAGHPSKGLMQVIPPTFAAYAPPGHGNILNPLDNILAAINYAKARYGS-GF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1931 GGWSPSGPRRYANGGLITKHqLAEVGEGDKQEMVIPLTRRKR 1972
Cdd:cd13402    77 ALAAGGGGGGYANGGIVTKG-LAEVGEGNKPEEVIPLDPAKR 117
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 1691-1812 1.23e-30

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 120.85  E-value: 1.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1691 QRFGRYTGGLNFNGGRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAG 1770
Cdd:COG0739    81 SGFGYRRHPVTGRRRFHKGIDIAAPTGTPVYAAADGTVVFAGWNGGYGNLVIIDHGNGYTTLYAHLSSILVKVGQRVKAG 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1771 QLIGKSGATGNfVRGAHLHFQLMQgshpgNDTAKDPEKWLKS 1812
Cdd:COG0739   161 QVIGYVGNTGR-STGPHLHFEVRV-----NGKPVDPLPFLPA 196
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 1705-1798 9.13e-28

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 108.79  E-value: 9.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1705 GRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGATGNfVR 1784
Cdd:pfam01551    1 RFHKGIDIAAPTGTPVYAAADGVVVFAGWLGGYGNLVIIDHGNGYSTLYAHLSSILVKVGQRVKAGQVIGTVGSTGR-ST 79

                           90
                   ....*....|....
gi 215401158  1785 GAHLHFQLMQGSHP 1798
Cdd:pfam01551   80 GPHLHFEIRKNGKP 93
M23_peptidase cd12797
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ...
 1707-1792 3.62e-27

M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.


Pssm-ID: 410984 [Multi-domain]  Cd Length: 85  Bit Score: 106.52  E-value: 3.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1707 HYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGATGNfVRGA 1786
Cdd:cd12797     1 HNGIDIAAPEGTPVYAAADGTVVFAGWDGGYGNYVIIDHGNGYYTLYAHLSSILVKVGQRVKKGQVIGTVGNTGR-STGP 79


                  ....*.
gi 215401158 1787 HLHFQL 1792
Cdd:cd12797    80 HLHFEI 85
PRK11649 PRK11649
putative peptidase; Provisional
 1701-1806 4.37e-13

putative peptidase; Provisional


Pssm-ID: 236946 [Multi-domain]  Cd Length: 439  Bit Score: 73.93  E-value: 4.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1701 NFNGGR----------HYGIDFGMPSGTNVYAVKGGiaDKVWTDYGG--GNSIQIKTGANEWNWYMHLSKQLARQGQRIK 1768
Cdd:PRK11649  297 NFNPRRlnpvtgrvapHRGVDFAMPVGTPVLAVGDG--EVVVAKRSGaaGNYVAIRHGRQYTTRYMHLRKLLVKPGQKVK 374

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 215401158 1769 AGQLIGKSGATGNFVrGAHLHFQLMQGSHPGND-TAKDP 1806
Cdd:PRK11649  375 RGDRIALSGNTGRST-GPHLHYEVWINQQAVNPlTAKLP 412
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-280 1.05e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     3 EKVEGMTLELKLDHLGVQEGMKGLKRQLGVVNSEMKAnlsafdkSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV 82
Cdd:TIGR02168  743 EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE-------AEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    83 NANYQKAKSSVKDVEKAylklVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQ----K 158
Cdd:TIGR02168  816 NEEAANLRERLESLERR----IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEealaL 891

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   159 LKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNL--------SKSNDKIESSYAKTNTKLKQTE 230
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLqerlseeySLTLEEAEALENKIEDDEEEAR 971

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158   231 KEFNDLNNTIK-----NHSA-----NVAKAETAVNKEKA----ALNNLERSIDKASSEMK-----TFNK 280
Cdd:TIGR02168  972 RRLKRLENKIKelgpvNLAAieeyeELKERYDFLTAQKEdlteAKETLEEAIEEIDREARerfkdTFDQ 1040
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 910-1140 9.39e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.99  E-value: 9.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   910 ETEKALEKYvhYSEENSRIMEKVRLNSGQISEDKAKKL--LKIETDLSNnliaeieKRNKKELEKTQelidKYSAFDEQE 987
Cdd:pfam17380  345 ERERELERI--RQEERKRELERIRQEEIAMEISRMRELerLQMERQQKN-------ERVRQELEAAR----KVKILEEER 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKEKNDLRIKKE---QELNQKIKELKEKALSDGQISENERK-EIEKLENQRRDITVKELSKtEKEQERILVRM 1063
Cdd:pfam17380  412 QRKIQQQKVEMEQIRAEQEearQREVRRLEEERAREMERVRLEEQERQqQVERLRQQEEERKRKKLEL-EKEKRDRKRAE 490

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1064 QRNRNAY--SIDEASKAIKEAEKARKARKKEVDKQyeDDVIAIKNNVNLSKSEKDKLLAIADQRH-KDEVRKA---KSKK 1137
Cdd:pfam17380  491 EQRRKILekELEERKQAMIEEERKRKLLEKEMEER--QKAIYEEERRREAEEERRKQQEMEERRRiQEQMRKAteeRSRL 568


                   ...
gi 215401158  1138 DAV 1140
Cdd:pfam17380  569 EAM 571
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
96-274 1.11e-09

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 62.61  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   96 VEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASD 175
Cdd:COG4372     8 VGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  176 AVQKQSAKHKALVEQ-------YKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVA 248
Cdd:COG4372    88 QLQAAQAELAQAQEEleslqeeAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167

                         170       180
                  ....*....|....*....|....*.
gi 215401158  249 KAETAVNKEKAAlnNLERSIDKASSE 274
Cdd:COG4372   168 ALEQELQALSEA--EAEQALDELLKE 191
PTZ00121 PTZ00121
MAEBL; Provisional
 893-1227 2.13e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  893 SKKASDTVKVLGKGVSKETEKALEkyVHYSEENSRIMEKVRL----NSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKK 968
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAeedkNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  969 ELEKTQELIDKYSAF-DEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITVK 1047
Cdd:PTZ00121 1611 EAKKAEEAKIKAEELkKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1048 ELSKTEKEQERILVRMQRNRNAYSIDEASKaIKEAEKARKARKKEVDKQYEDDVIAIKnNVNLSKSEKDKLLAIADQRHK 1127
Cdd:PTZ00121 1691 AEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENKIKAEEAKKEAEEDKKKAE-EAKKDEEEKKKIAHLKKEEEK 1768

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1128 DEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEKWWNGLKSwWSNFREDQKKKSDKYAKEQEETARRNRENIK 1207
Cdd:PTZ00121 1769 KAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE-GNLVINDSKEMEDSAIKEVADSKNMQLEEAD 1847

                         330       340
                  ....*....|....*....|....*
gi 215401158 1208 -----KWFGNAWDGVKSKTGEAFSK 1227
Cdd:PTZ00121 1848 afekhKFNKNNENGEDGNKEADFNK 1872
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 23-281 3.71e-08

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 56.19  E-value: 3.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    23 MKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLkvqkkmySQVEDELKQVNanyqkakssvKDVEKAYLK 102
Cdd:pfam00261    3 MQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRI-------QLLEEELERTE----------ERLAEALEK 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   103 LVEANKkeklALDKSKEALKS-SNTELK------KAENQYKRTNQRKQDAyqkLKQLRDAEQKLKnsnqATTAQLKRASD 175
Cdd:pfam00261   66 LEEAEK----AADESERGRKVlENRALKdeekmeILEAQLKEAKEIAEEA---DRKYEEVARKLV----VVEGDLERAEE 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   176 AVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEkefndlnntiknhsANVAKAETAVN 255
Cdd:pfam00261  135 RAELAESKIVELEEELKVVGNNLKSLEASEEKASEREDKYEEQIRFLTEKLKEAE--------------TRAEFAERSVQ 200

                          250       260
                   ....*....|....*....|....*.
gi 215401158   256 KEKAALNNLERSIDKASSEMKTFNKE 281
Cdd:pfam00261  201 KLEKEVDRLEDELEAEKEKYKAISEE 226
PTZ00121 PTZ00121
MAEBL; Provisional
 47-260 1.57e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   47 SEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV----NANYQKAKSSVKDVEKAYLKLVEANKKEKLAlDKSKEALK 122
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAeekkKADEAKKAEEKKKADEAKKKAEEAKKADEAK-KKAEEAKK 1329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  123 SSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKA-----LVEQYKQEGNQ 197
Cdd:PTZ00121 1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeakkKAEEDKKKADE 1409

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  198 VQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDlnnTIKNHSANVAKAETAVNKEKAA 260
Cdd:PTZ00121 1410 LKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD---EAKKKAEEAKKAEEAKKKAEEA 1469
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 891-1202 3.86e-07

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 55.40  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  891 TASKKASDTVKVLGKGVSKETEKALEKyVHYSEENSRIMEKVRLNsgqisedkaKKLLKIETDLSNNLIAEIEKRNKKEL 970
Cdd:NF033838   47 TVTSSGNESQKEHAKEVESHLEKILSE-IQKSLDKRKHTQNVALN---------KKLSDIKTEYLYELNVLKEKSEAELT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  971 EKTQELIDkySAFdEQEKQNILTRTKEKNDLRiKKEQELNQKIKELKEKALSDgqISENERKEIEkLENQRRDITVKEls 1050
Cdd:NF033838  117 SKTKKELD--AAF-EQFKKDTLEPGKKVAEAT-KKVEEAEKKAKDQKEEDRRN--YPTNTYKTLE-LEIAESDVEVKK-- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1051 kteKEQERILVRMQRNRNAYSIDEAsKAIKEAEKARKARKKEV--DKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKD 1128
Cdd:NF033838  188 ---AELELVKEEAKEPRDEEKIKQA-KAKVESKKAEATRLEKIktDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKR 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158 1129 EVRKAKSKKDAVVDvvKKQNKDidKEMDLSSGRVYKNTEKWWNGLKSwwsnfREDQKKK--SDKYAKEQEETARRN 1202
Cdd:NF033838  264 RAKRGVLGEPATPD--KKENDA--KSSDSSVGEETLPSPSLKPEKKV-----AEAEKKVeeAKKKAKDQKEEDRRN 330
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 907-1143 9.59e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 9.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   907 VSKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKaKKLLKIETDL--SNNLIAEIEKR------NKKELEKTQELID 978
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELyaLANEISRLEQQkqilreRLANLERQLEELE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   979 KYSAFDEQEKQNILTR----TKEKNDLRIKKE------QELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITvKE 1048
Cdd:TIGR02168  323 AQLEELESKLDELAEElaelEEKLEELKEELEsleaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN-NE 401

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1049 LSKTEKEQERILVRMQRNRNaySIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQR--- 1125
Cdd:TIGR02168  402 IERLEARLERLEDRRERLQQ--EIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAlda 479

                          250
                   ....*....|....*...
gi 215401158  1126 HKDEVRKAKSKKDAVVDV 1143
Cdd:TIGR02168  480 AERELAQLQARLDSLERL 497
TOPEUc smart00435
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ...
 48-145 6.21e-05

DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras


Pssm-ID: 214661 [Multi-domain]  Cd Length: 391  Bit Score: 47.73  E-value: 6.21e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     48 EKSMEKYQARIKGLNDRLKVQKKMYsqveDELKQVNANYQKAKSSV-KDVEKAYLKlVEANKKEKLALDKSKEALKSSNT 126
Cdd:smart00435  276 EKSMEKLQEKIKALKYQLKRLKKMI----LLFEMISDLKRKLKSKFeRDNEKLDAE-VKEKKKEKKKEEKKKKQIERLEE 350

                            90
                    ....*....|....*....
gi 215401158    127 ELKKAENQYKRTNQRKQDA 145
Cdd:smart00435  351 RIEKLEVQATDKEENKTVA 369
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 917-1392 7.15e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.12  E-value: 7.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   917 KYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKrNKKELEKTQELIDKY--------SAFDEQEK 988
Cdd:TIGR01612 1457 KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADK-NAKAIEKNKELFEQYkkdvtellNKYSALAI 1535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   989 QNILTRTKEKNDLRIKKeqelnqkIKELKEKALSDGQISENERKEI----------------------------EKLENQ 1040
Cdd:TIGR01612 1536 KNKFAKTKKDSEIIIKE-------IKDAHKKFILEAEKSEQKIKEIkkekfrieddaakndksnkaaidiqlslENFENK 1608

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1041 RRDIT---------VKELSKTEKEQERILVRMQRNR------NAYSIDEASKAIKEAEKARKARKKEVD------KQYED 1099
Cdd:TIGR01612 1609 FLKISdikkkindcLKETESIEKKISSFSIDSQDTElkengdNLNSLQEFLESLKDQKKNIEDKKKELDeldseiEKIEI 1688

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1100 DVIAIKNNVNLSKSEKDKLLAIADqrhKDEVRKAK-SKKDAVVDVVKKQNKD----IDKEMDLSS-----GRVYKNTEKW 1169
Cdd:TIGR01612 1689 DVDQHKKNYEIGIIEKIKEIAIAN---KEEIESIKeLIEPTIENLISSFNTNdlegIDPNEKLEEynteiGDIYEEFIEL 1765

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1170 WNGLkswwSNFREDQKKKSDKYakEQEETARRNREN-------IKKWFGNAWDGVKSKtgeafsKMGRNANHFggemkkm 1242
Cdd:TIGR01612 1766 YNII----AGCLETVSKEPITY--DEIKNTRINAQNeflkiieIEKKSKSYLDDIEAK------EFDRIINHF------- 1826

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1243 wsgikgiPSKLSSGWSSAKSSVGYHTKAIANstgkwFGKAWQSVKSTTG-----SIYNQTKQKYSDASDKAWAHSKSiwr 1317
Cdd:TIGR01612 1827 -------KKKLDHVNDKFTKEYSKINEGFDD-----ISKSIENVKNSTDenllfDILNKTKDAYAGIIGKKYYSYKD--- 1891

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1318 GTSKWFSNAYKSAKGWLTDMANKSRAK-WDNISSTAWSNAKSVWKGTSKWFSNSYKSlkdwtGDMYSRAHDRFDAI 1392
Cdd:TIGR01612 1892 EAEKIFINISKLANSINIQIQNNSGIDlFDNINIAILSSLDSEKEDTLKFIPSPEKE-----PEIYTKIRDSYDTL 1962
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 90-243 1.68e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 45.13  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   90 KSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKN-SNQATTA 168
Cdd:cd00176    53 EERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEkEAALASE 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215401158  169 QLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNdkIESSYAKTNTKLKQTEKEFNDLNNTIKNH 243
Cdd:cd00176   133 DLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAEELLEEG--HPDADEEIEEKLEELNERWEELLELAEER 205
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 1803-1915 1.71e-04

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 45.37  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1803 AKDPEKWLKSLKGSGVRSGSGVNKAASAWAGDIRRAAKRMGVnvtsgDVGNIISLIQHESGGNAGITqSSAlrdinvlqg 1882
Cdd:COG0741    75 ALAAFAAIAALAAELLALAALLLRRPLPYLPLIEEAAKKYGV-----DPALVLALIRQESAFNPNAV-SPA--------- 139

                          90       100       110
                  ....*....|....*....|....*....|...
gi 215401158 1883 nPAKGLLQYIPQTFRHYAVRGhnNIYSGYDQLL 1915
Cdd:COG0741   140 -GARGLMQLMPATARRLGLKL--GLGPSPDDLF 169
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 942-1051 2.73e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 45.39  E-value: 2.73e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    942 DKAKKLLKIETDLSNNLIAEIEKRnKKELEKTQELIDKYSAFDEQEKQNILTRTKEK-------NDLRIKKEQELNQKIK 1014
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDR-KDALEEELRQLKQLEDELEDCDPTELDRAKEKlkkllqeIMIKVKKLEELEEELQ 235

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|.
gi 215401158   1015 ELKEKaLSDG--QISE--NERKEIEKLENQRRDITVKELSK 1051
Cdd:smart00787  236 ELESK-IEDLtnKKSElnTEIAEAEKKLEQCRGFTFKEIEK 275
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 89-309 2.07e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 43.28  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   89 AKSSVKDVEKAYLKLVEANKKEKLAL-DKskealkssntelKKAENQYKRTNQRKQDAYQKL----KQLRDAEQ-KLKNS 162
Cdd:NF012221 1536 ATSESSQQADAVSKHAKQDDAAQNALaDK------------ERAEADRQRLEQEKQQQLAAIsgsqSQLESTDQnALETN 1603

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  163 NQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDN------LSKSNDKIESSYAKTNTKLKQTEKEFNDL 236
Cdd:NF012221 1604 GQAQRDAILEESRAVTKELTTLAQGLDALDSQATYAGESGDQWRNpfagglLDRVQEQLDDAKKISGKQLADAKQRHVDN 1683

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  237 NNTIKNhsaNVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIGDK 309
Cdd:NF012221 1684 QQKVKD---AVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQ 1753
FCH_F-BAR cd07610
The Extended FES-CIP4 Homology (FCH) or F-BAR (FCH and Bin/Amphiphysin/Rvs) domain, a ...
 903-1069 2.39e-03

The Extended FES-CIP4 Homology (FCH) or F-BAR (FCH and Bin/Amphiphysin/Rvs) domain, a dimerization module that binds and bends membranes; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. F-BAR domain containing proteins, also known as Pombe Cdc15 homology (PCH) family proteins, include Fes and Fer tyrosine kinases, PACSINs/Syndapins, FCHO, PSTPIP, CIP4-like proteins and srGAPs. Many members also contain an SH3 domain and play roles in endocytosis. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. These tubules have diameters larger than those observed with N-BARs. The F-BAR domains of some members such as NOSTRIN and Rgd1 are important for the subcellular localization of the protein.


Pssm-ID: 153294 [Multi-domain]  Cd Length: 191  Bit Score: 41.17  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  903 LGKGVSKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDK------AKKLLKIETDLSNNLIAEIEKRnkkeleKTQEL 976
Cdd:cd07610    11 LGLDLLKDLREFLKKRAAIEEEYAKNLQKLAKKFSKKPESGktslgtSWNSLREETESAATVHEELSEK------LSQLI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  977 IDKYSAFDEQEKQNiltRTKEKNDLRiKKEQELNQKIKELKEKALSDgqisenERKEIEKLENQRRDITVKELSKTEKEQ 1056
Cdd:cd07610    85 REPLEKVKEDKEQA---RKKELAEGE-KLKKKLQELWAKLAKKADEE------YREQVEKLNPAQSEYEEEKLNKIQAEQ 154

                         170
                  ....*....|...
gi 215401158 1057 ERILVRMQRNRNA 1069
Cdd:cd07610   155 EREEERLEILKDN 167
 
Name Accession Description Interval E-value
tape_meas_TP901 TIGR01760
phage tail tape measure protein, TP901 family, core region; This model represents a reasonably ...
 322-669 9.86e-111

phage tail tape measure protein, TP901 family, core region; This model represents a reasonably well conserved core region of a family of phage tail proteins. The member from phage TP901-1 was characterized as a tail length tape measure protein in that a shortened form of the protein leads to phage with proportionately shorter tails. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273790 [Multi-domain]  Cd Length: 350  Bit Score: 357.05  E-value: 9.86e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   322 STPITLGLGAALKTSADFEGQMSRVGAIAQAS-SKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMP 400
Cdd:TIGR01760    1 SAALGGGLVAAVKAAIEFEDAMSGVRAVVDGSrTKEFEDLSNQARDLGDETPFSAAQIAGAMTALARAGISAKDLLGATP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   401 GVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAI 480
Cdd:TIGR01760   81 TALKLAAASDLTAEEAASILAKIMNAFGLTAKDSEKVADVLNYTANNSAATTRDMGDALQYAGPVAKSLGVSLEETAAAT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   481 EVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVG 560
Cdd:TIGR01760  161 AALASAGIEGEIAGTALKAMLSRLAAPTGKAAKALKKLGIQTRDAKGNMKGLLDVLKELQKLTKGMGTEQQAAKLKTIFG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   561 TEAASGFLALIEAGPD-KINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKL 639
Cdd:TIGR01760  241 VEASSALATLLTAGSKlSLAKNAKSLANSNGSAKKEADKMLDTLKGQLKLLQNAVENAFIELGEALLPALRELAQALTKL 320

                          330       340       350
                   ....*....|....*....|....*....|
gi 215401158   640 VDGFTHLPGWVRKASVGLALFGAAIGPAVL 669
Cdd:TIGR01760  321 INAINGLAKGNPQLAVTLAAVAAAILALTA 350
YqbO COG5280
Phage-related minor tail protein [Mobilome: prophages, transposons];
301-1121 9.76e-94

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444091 [Multi-domain]  Cd Length: 962  Bit Score: 328.04  E-value: 9.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  301 KKFSSIGDKMTSLGRTMTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAK 380
Cdd:COG5280    35 EKMDRAGKKMKSIGAALTAGVTAALVAAGAAAVKAAADFEKAMSTVQAVTGATGEELEALEQLAKELGATTGESAAEVAE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  381 GMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALK 460
Cdd:COG5280   115 ALGSVAQAGLSGDELIAVTEGALVLAAATGVDLNEAAEIVASAMNAFGLSADEASRVADLLAAGAQAGNTTSDELADALK 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  461 YAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQ 540
Cdd:COG5280   195 EYAPLAAALGFSLEETLAALALLANAGIKGSDAGTALKEFLIRLADPSKTAAEALEELGINVFDASGKLKGLSEILGELA 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  541 DNMKGMTREQKLATVATIVGTEAASGFLALIEAGPDKINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIE 620
Cdd:COG5280   275 KKFAGLGEAARAAVLAAIFGDDAGRAAIALLLFGTDWYAKLTAALKNSAGAADEAAATMQDNLAGALESLKSALEGLAIT 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  621 VGKDLTPMIRAGAEGLTKLVDGFTHLPGWVRKASVGLALFGAAIGPAVLAGGLLIRTVGSAAKGYASLnrriaentilsn 700
Cdd:COG5280   355 IGETLLPALRDAVEALTGLADWFNELSPAVQELIIAIAGLVAALGPLLLILGALITGIGALAGAFGIL------------ 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  701 tnSKAMKSLGLQTLFlgSTTGKTSKGFKGLAGAMMFNLKPINVLKNSAKLAILPFKLLKNGLGLAAKSLFAVSGGARFAG 780
Cdd:COG5280   423 --STALAKAKGALLA--GPIGIVIAAIAALAAALVLLYKNWDTIKEFLTGLWNSIKEAIGGVWDGIKTSVEGLKGAAGAA 498

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  781 valrfLTGPIGATITAITIAYKVFKTAYDRVEWFRNGINGLGETIKFFGGKIIGGAVRKLGEfknylgSIGKSFKEKFSK 860
Cdd:COG5280   499 -----LSAAAGKAIEALAGISVDALKQGVILSGTISMLWGAAGTEVSLKGGAAQDNVSDAAS------SAGDGALAIINS 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  861 DMKDGYKSLSDDDLLKVGVNKFKGFMQTMGTASKKASDTVKVLGKGVSKETEKALEKYVHYSEENSRIMEKVRlNSGQIS 940
Cdd:COG5280   568 AEQAIIGLAAALKTASTSSALQASTKAAAATKAEKTILAIAMATVKGVTSATAALANAAGVILQGAIKNGISG-ALDSAG 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKEQELNQ-KIKELKEK 1019
Cdd:COG5280   647 ATTVAKLAEEEAINEKIVELLKAAANGANKEAVANALLLDAAAKQNINGQEAILEGITAKGVQTDELQDSDaIQAKFQFE 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1020 ALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILV-RMQRNRNAYsIDEASKAIKEAEKARKARKKEVDKQYE 1098
Cdd:COG5280   727 ELSEGAKATINAINGNGVLGGIIADGIKTNSAELKAAANELKgDINRVAAAI-NSLAEAGAEEIKSEAKEAGSDKAITGE 805

                         810       820
                  ....*....|....*....|...
gi 215401158 1099 DDVIAIKNNVNLSKSEKDKLLAI 1121
Cdd:COG5280   806 AGQAALELAVARVNALISRVTKN 828
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
201-889 1.11e-75

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 269.03  E-value: 1.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  201 LKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNK 280
Cdd:COG5283     5 LGAVDKPFKSALESAKQRVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDTRQLSA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  281 EQMIAQSHFGKLASQADVMSKKFSSIGDKMTSLGRT--------MTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQA 352
Cdd:COG5283    85 AQRRLRSSLEQTNRQLERQQQRLARLGARQDRLKAArarlqrlaGAGAAAAAIGAALAASVKPAIDFEDAMADVAATVDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  353 --SSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLK 430
Cdd:COG5283   165 dkSSEQFKALGKQARELSAQTPQSADDIAAGQAALAQAGVSAEDILAFTPTAAKLATAFDTDAEEAAEIAAKILNAFKLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  431 ASDANHVADLLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKN 510
Cdd:COG5283   245 ADDVERLGDALNYAGNNGATSLADLADALPYVGPVAKALGVSGKEAAALGAALADAGIEGEEAGTALRNMLTRLTSPTKA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  511 TAKEMKKLGIHLSDAKGQFVGM------------GELIRQFQDNMKGMTREQKLATVATIVGTEAASGFLALIEAGPD-K 577
Cdd:COG5283   325 AAKALKKLGIDTQDSKGNLRGLakilakqmqkdaQGALAELLKALKKLDAAKRAAALKQLFGEEAVSALAPLLQNGDElR 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  578 INSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKLVDGFTHLPGWVRKASVGL 657
Cdd:COG5283   405 KQLAVAEAAAAQGSMDKEAAKRTDTLAGQLKLLKNALENLGISIGEALLPALRELAQALTPVVGKLADWAKANPGLIKTI 484

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  658 ALFGAAIGPAVLAGGLLIRTVGSAAKGYASLNRRIAentilsntnskamkslglqtLFLGSTTGKTSKGFKGLAgammfn 737
Cdd:COG5283   485 VKVAAALAGLKAALGALRLALALLLSPLAALKAAAA--------------------LLGGGGLGGAGRGAGALA------ 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  738 lkpinvlknsaklailpfkllknGLGlAAKSLFAVSGGARFAGVALrfLTGPIGATITAITI-AYKVFKTaydrveWfrn 816
Cdd:COG5283   539 -----------------------ALG-GAKGLKLAGGAVLWLGRAL--LANPIGLVIAAIAAaAYLIYKY------W--- 583

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  817 ginglgETIKFFGGKIIGGavrklgeFKNYLGSIGKSFKEKFSKDMKDGYKSLSDDDLLKVGVNKFKGFMQTM 889
Cdd:COG5283   584 ------EPIKAFFKGVWEG-------IKAAFSPAWEAIKALISNWLGPVWDGLAIAGAGAGEAAAAAAVAGAQ 643
PhageMin_Tail pfam10145
Phage-related minor tail protein; Members of this family are found in putative phage tail tape ...
 361-560 4.51e-52

Phage-related minor tail protein; Members of this family are found in putative phage tail tape measure proteins.


Pssm-ID: 462962 [Multi-domain]  Cd Length: 201  Bit Score: 182.50  E-value: 4.51e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   361 SNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMPGVISAAEASGA-EMATTATVMASAINSFGLKASDANHVAD 439
Cdd:pfam10145    1 RDAALELGETTGFSATDAAEAMAALASAGLSAEELLSATEGALKLAVAGGAtDAAEAAEALAAAMNAFGLSADDAEEAAD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   440 LLARSANDSAADIQYMGDALKYAGTPAKALGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLG 519
Cdd:pfam10145   81 VLAAAANNGATEVGDLADALKEVGPVAKAAGLSGEETAAALALLAAAGISGSEAGTALKNFLTRLAAPTKEAAKALKKLG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 215401158   520 IHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVG 560
Cdd:pfam10145  161 ISAKDANGKMKSLSEILEELAQALKGLTDAQRAAALSALFG 201
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 1851-1972 9.39e-44

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 155.05  E-value: 9.39e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1851 VGNIISLIQHESGGNAGITQssaLRDINVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQLLAFFNNRYWRSQFnPR 1930
Cdd:cd13402     1 LNALLRQIQTESGGNPNAIN---NWDSNAKAGHPSKGLMQVIPPTFAAYAPPGHGNILNPLDNILAAINYAKARYGS-GF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1931 GGWSPSGPRRYANGGLITKHqLAEVGEGDKQEMVIPLTRRKR 1972
Cdd:cd13402    77 ALAAGGGGGGYANGGIVTKG-LAEVGEGNKPEEVIPLDPAKR 117
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 1691-1812 1.23e-30

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 120.85  E-value: 1.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1691 QRFGRYTGGLNFNGGRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAG 1770
Cdd:COG0739    81 SGFGYRRHPVTGRRRFHKGIDIAAPTGTPVYAAADGTVVFAGWNGGYGNLVIIDHGNGYTTLYAHLSSILVKVGQRVKAG 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 215401158 1771 QLIGKSGATGNfVRGAHLHFQLMQgshpgNDTAKDPEKWLKS 1812
Cdd:COG0739   161 QVIGYVGNTGR-STGPHLHFEVRV-----NGKPVDPLPFLPA 196
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 1705-1798 9.13e-28

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 108.79  E-value: 9.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1705 GRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGATGNfVR 1784
Cdd:pfam01551    1 RFHKGIDIAAPTGTPVYAAADGVVVFAGWLGGYGNLVIIDHGNGYSTLYAHLSSILVKVGQRVKAGQVIGTVGSTGR-ST 79

                           90
                   ....*....|....
gi 215401158  1785 GAHLHFQLMQGSHP 1798
Cdd:pfam01551   80 GPHLHFEIRKNGKP 93
M23_peptidase cd12797
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ...
 1707-1792 3.62e-27

M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.


Pssm-ID: 410984 [Multi-domain]  Cd Length: 85  Bit Score: 106.52  E-value: 3.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1707 HYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGATGNfVRGA 1786
Cdd:cd12797     1 HNGIDIAAPEGTPVYAAADGTVVFAGWDGGYGNYVIIDHGNGYYTLYAHLSSILVKVGQRVKKGQVIGTVGNTGR-STGP 79


                  ....*.
gi 215401158 1787 HLHFQL 1792
Cdd:cd12797    80 HLHFEI 85
SLT COG3953
SLT domain protein [Mobilome: prophages, transposons];
1711-1945 4.14e-26

SLT domain protein [Mobilome: prophages, transposons];


Pssm-ID: 443153 [Multi-domain]  Cd Length: 325  Bit Score: 111.35  E-value: 4.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1711 DFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGK-----SGATGNFVRG 1785
Cdd:COG3953    93 SGAGPTSGGGAAAAGIGAGGAGNWLGNQAASGSSGAIGVAGGGKKVAGAANKAAKASSKAVAKGKtkavkGGGGISSGSG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1786 AHLHFQLMQGSHPGNDTAKDPEKWlkslKGSGVRSGSGVNKAASAWAGDIRRAAKrMGVNVTSGDVGNIISLIQHESGGN 1865
Cdd:COG3953   173 GGAQAATGKGGGGLGKGASKALGG----AGAGAGGGGGVGGGAGGWGIDIRQAAA-LGVPVSEAWVDGILRIIQHESGGN 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1866 AGITQssaLRDINVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQLLAFFNnrYWRSqfnpRGGWSPSGPRRYANGG 1945
Cdd:COG3953   248 PNAIN---LWDSNAAAGTPSKGLMQVIPPTFNAYKLPGHGNIYNPVDNILAGIN--YAKS----RYGSSDNVPGLASLGQ 318
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1691-1811 5.27e-16

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 82.12  E-value: 5.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1691 QRFGRYTGGlnfnGGRHYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAG 1770
Cdd:COG4942   265 RRFGERDGG----GGRNKGIDIAAPPGAPVRAVADGTVVYAGWLRGYGNLVIIDHGGGYLTLYAHLSSLLVKVGQRVKAG 340

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 215401158 1771 QLIGKSGATGNfVRGAHLHFQLMQgshpgNDTAKDPEKWLK 1811
Cdd:COG4942   341 QPIGTVGSSGG-QGGPTLYFELRK-----NGKPVDPLPWLA 375
SpoIIQ2 COG5821
Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell ...
 1707-1811 2.31e-14

Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444523 [Multi-domain]  Cd Length: 200  Bit Score: 73.91  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1707 HYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHL-SKQLARQGQRIKAGQLIGKSGATGNFVR- 1784
Cdd:COG5821    97 HTGIDIAAKEGTPVKAAADGVVVEVGKDPKYGITVVIDHGNGIKTVYANLdSKIKVKVGQKVKKGQVIGKVGSTALFESs 176

                          90       100
                  ....*....|....*....|....*...
gi 215401158 1785 -GAHLHFQLMQgshpgNDTAKDPEKWLK 1811
Cdd:COG5821   177 eGPHLHFEVLK-----NGKPVDPMKYLK 199
PRK11649 PRK11649
putative peptidase; Provisional
 1701-1806 4.37e-13

putative peptidase; Provisional


Pssm-ID: 236946 [Multi-domain]  Cd Length: 439  Bit Score: 73.93  E-value: 4.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1701 NFNGGR----------HYGIDFGMPSGTNVYAVKGGiaDKVWTDYGG--GNSIQIKTGANEWNWYMHLSKQLARQGQRIK 1768
Cdd:PRK11649  297 NFNPRRlnpvtgrvapHRGVDFAMPVGTPVLAVGDG--EVVVAKRSGaaGNYVAIRHGRQYTTRYMHLRKLLVKPGQKVK 374

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 215401158 1769 AGQLIGKSGATGNFVrGAHLHFQLMQGSHPGND-TAKDP 1806
Cdd:PRK11649  375 RGDRIALSGNTGRST-GPHLHYEVWINQQAVNPlTAKLP 412
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-280 1.05e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     3 EKVEGMTLELKLDHLGVQEGMKGLKRQLGVVNSEMKAnlsafdkSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV 82
Cdd:TIGR02168  743 EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE-------AEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    83 NANYQKAKSSVKDVEKAylklVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQ----K 158
Cdd:TIGR02168  816 NEEAANLRERLESLERR----IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEealaL 891

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   159 LKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNL--------SKSNDKIESSYAKTNTKLKQTE 230
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLqerlseeySLTLEEAEALENKIEDDEEEAR 971

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158   231 KEFNDLNNTIK-----NHSA-----NVAKAETAVNKEKA----ALNNLERSIDKASSEMK-----TFNK 280
Cdd:TIGR02168  972 RRLKRLENKIKelgpvNLAAieeyeELKERYDFLTAQKEdlteAKETLEEAIEEIDREARerfkdTFDQ 1040
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 19-264 2.65e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 2.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLN---DRLKVQKKMYS----QVEDELKQVNANYQKAKS 91
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALAneiSRLEQQKQILRerlaNLERQLEELEAQLEELES 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    92 SVKDVEKAylklVEANKKEKLALDKSKEALKSsntELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLK 171
Cdd:TIGR02168  331 KLDELAEE----LAELEEKLEELKEELESLEA---ELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   172 RASDavQKQSAKHKalVEQYKQEGNQVQKLKVQNDnlsksNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAE 251
Cdd:TIGR02168  404 RLEA--RLERLEDR--RERLQQEIEELLKKLEEAE-----LKELQAELEELEEELEELQEELERLEEALEELREELEEAE 474

                          250
                   ....*....|...
gi 215401158   252 TAVNKEKAALNNL 264
Cdd:TIGR02168  475 QALDAAERELAQL 487
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 28-281 9.22e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.89  E-value: 9.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    28 RQLGVVNSEMKANLSAFDK--SEKSMEKYQARIKGLNDRLKVQKKMysqvedeLKQVNANYQKAKSSVK-DVEKAYLKLV 104
Cdd:TIGR04523   52 KEKELKNLDKNLNKDEEKInnSNNKIKILEQQIKDLNDKLKKNKDK-------INKLNSDLSKINSEIKnDKEQKNKLEV 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   105 EANKKEKlALDKSKEALKSSNTELKKAENQ-------YKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRasdaV 177
Cdd:TIGR04523  125 ELNKLEK-QKKENKKNIDKFLTEIKKKEKEleklnnkYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLK----L 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   178 QKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKE 257
Cdd:TIGR04523  200 ELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQN 279

                          250       260
                   ....*....|....*....|....
gi 215401158   258 KAALNNLERSIDKASSEMKTFNKE 281
Cdd:TIGR04523  280 NKKIKELEKQLNQLKSEISDLNNQ 303
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 910-1140 9.39e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.99  E-value: 9.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   910 ETEKALEKYvhYSEENSRIMEKVRLNSGQISEDKAKKL--LKIETDLSNnliaeieKRNKKELEKTQelidKYSAFDEQE 987
Cdd:pfam17380  345 ERERELERI--RQEERKRELERIRQEEIAMEISRMRELerLQMERQQKN-------ERVRQELEAAR----KVKILEEER 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKEKNDLRIKKE---QELNQKIKELKEKALSDGQISENERK-EIEKLENQRRDITVKELSKtEKEQERILVRM 1063
Cdd:pfam17380  412 QRKIQQQKVEMEQIRAEQEearQREVRRLEEERAREMERVRLEEQERQqQVERLRQQEEERKRKKLEL-EKEKRDRKRAE 490

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1064 QRNRNAY--SIDEASKAIKEAEKARKARKKEVDKQyeDDVIAIKNNVNLSKSEKDKLLAIADQRH-KDEVRKA---KSKK 1137
Cdd:pfam17380  491 EQRRKILekELEERKQAMIEEERKRKLLEKEMEER--QKAIYEEERRREAEEERRKQQEMEERRRiQEQMRKAteeRSRL 568


                   ...
gi 215401158  1138 DAV 1140
Cdd:pfam17380  569 EAM 571
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
96-274 1.11e-09

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 62.61  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   96 VEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASD 175
Cdd:COG4372     8 VGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  176 AVQKQSAKHKALVEQ-------YKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVA 248
Cdd:COG4372    88 QLQAAQAELAQAQEEleslqeeAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167

                         170       180
                  ....*....|....*....|....*.
gi 215401158  249 KAETAVNKEKAAlnNLERSIDKASSE 274
Cdd:COG4372   168 ALEQELQALSEA--EAEQALDELLKE 191
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
19-237 1.35e-09

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 62.23  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEK 98
Cdd:COG4372    43 LQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   99 AYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEqklknSNQATTAQLKRASDAVQ 178
Cdd:COG4372   123 ERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAE-----AEQALDELLKEANRNAE 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158  179 KQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLN 237
Cdd:COG4372   198 KEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVI 256
PTZ00121 PTZ00121
MAEBL; Provisional
 893-1227 2.13e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  893 SKKASDTVKVLGKGVSKETEKALEkyVHYSEENSRIMEKVRL----NSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKK 968
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAeedkNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  969 ELEKTQELIDKYSAF-DEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITVK 1047
Cdd:PTZ00121 1611 EAKKAEEAKIKAEELkKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1048 ELSKTEKEQERILVRMQRNRNAYSIDEASKaIKEAEKARKARKKEVDKQYEDDVIAIKnNVNLSKSEKDKLLAIADQRHK 1127
Cdd:PTZ00121 1691 AEALKKEAEEAKKAEELKKKEAEEKKKAEE-LKKAEEENKIKAEEAKKEAEEDKKKAE-EAKKDEEEKKKIAHLKKEEEK 1768

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1128 DEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEKWWNGLKSwWSNFREDQKKKSDKYAKEQEETARRNRENIK 1207
Cdd:PTZ00121 1769 KAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE-GNLVINDSKEMEDSAIKEVADSKNMQLEEAD 1847

                         330       340
                  ....*....|....*....|....*
gi 215401158 1208 -----KWFGNAWDGVKSKTGEAFSK 1227
Cdd:PTZ00121 1848 afekhKFNKNNENGEDGNKEADFNK 1872
PTZ00121 PTZ00121
MAEBL; Provisional
 894-1208 2.77e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 2.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  894 KKASDTVKVLGKGVSKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKiETDLSNNLIAEIEKRNKKELEKT 973
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAE-EAKKAAEAAKAEAEAAADEAEAA 1362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  974 QEL--IDKYSAFDEQEKQNILTRTKE---KNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIE---------KLEN 1039
Cdd:PTZ00121 1363 EEKaeAAEKKKEEAKKKADAAKKKAEekkKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEkkkadeakkKAEE 1442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1040 QRRDITVKELSKTEKEQERILVRMQRNRNAysiDEASKAIKEAEKARKARKK-EVDKQYEDDVI----AIKNNVNLSKSE 1114
Cdd:PTZ00121 1443 AKKADEAKKKAEEAKKAEEAKKKAEEAKKA---DEAKKKAEEAKKADEAKKKaEEAKKKADEAKkaaeAKKKADEAKKAE 1519

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1115 K----DKLLAIADQRHKDEVRKAKSKKDA--------------VVDVVKKQNKDIDKEMDLSSGRVYKNTEKwwNGLKSW 1176
Cdd:PTZ00121 1520 EakkaDEAKKAEEAKKADEAKKAEEKKKAdelkkaeelkkaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEE--ARIEEV 1597

                         330       340       350
                  ....*....|....*....|....*....|..
gi 215401158 1177 WSNFREDQKKKSDKYAKEQEEtaRRNRENIKK 1208
Cdd:PTZ00121 1598 MKLYEEEKKMKAEEAKKAEEA--KIKAEELKK 1627
COG5412 COG5412
Phage-related protein [Mobilome: prophages, transposons];
408-861 5.13e-09

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 444167 [Multi-domain]  Cd Length: 704  Bit Score: 61.64  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  408 ASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALK-YAGTPAKALGVSIEDTSAAIEVLSNS 486
Cdd:COG5412     2 AAADASAKEAASAALLLAQAKAADSELTAASGGVVSAAAKAQGSIAQLGKIGAaAGAEAALADSSLAFATLAAALGATVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  487 GLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIHLSDAKGQFVGMGELIRQFQDNMKGMTREQKLATVATIVGTEAASG 566
Cdd:COG5412    82 GASLLLAAGGARAKGSAAAAAALGAVAAAAKVLNGALAAAGAALAATQALAAAATGAKGEANAAAKAGGAAALASAGLAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  567 FLALIEAgpDKINSYSKSLKNSNGESKKAADLMKDNLKGALEQLGGAFESLAIEVGKDLTPMIRAGAEGLTKLvdgfthl 646
Cdd:COG5412   162 AGAAAAA--SALAAAGAIAKAILSASKLSGQALAGQSAAAGGALEAAAAAAAGAAAAGAAAAAATAASALLAL------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  647 pgwvrKASVGLALFGAAIGPAVLAGGLLIRTVGSAAKGYASLNRRIAENTILSNTNSKAMKSLGLQTLFLGSTTGKTSKG 726
Cdd:COG5412   233 -----AALQGLAAGAATGAAAGAAGAAGLGAAGAGAGQAAALLGLVAGAEASGGTAGGAVAGLAAGLAAAAGASANLGAA 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  727 FKGLAGA-MMFNLKPINVLKNSAKLAILPFKLLKNGLGLAAKSLFAVSGG-------------ARFAGVALRFLTGPIGA 792
Cdd:COG5412   308 AAASFGAsLAASAGVDTAAAALAAAEAIADGSLVAGLGSAGTVLSTLSGAvgglegaigqlgaAGGLGSALGGLTGPIGI 387

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158  793 TITAITIAYKVFKTAYDRVEWFRNGINGLGETIKFfgGKIIGGAVRKLGEFknyLGSIGKSFKEKFSKD 861
Cdd:COG5412   388 VIAAIAALIAAFVALWKNSETFRNLVQGVWELNAI--KTAIEGVVSAIVTF---ISALWEAIKALLTAI 451
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
93-388 6.35e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   93 VKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKR 172
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  173 ASDAVQKQSAKHK---------ALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTklkQTEKEFNDLNNTIKNH 243
Cdd:COG4717   128 LPLYQELEALEAElaelperleELEERLEELRELEEELEELEAELAELQEELEELLEQLSL---ATEEELQDLAEELEEL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  244 SANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQ--SHFGKLASQADVMSKKFSSIGDKMTSLGrtMTMGV 321
Cdd:COG4717   205 QQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEarLLLLIAAALLALLGLGGSLLSLILTIAG--VLFLV 282

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158  322 STPITLGLGAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAAL 388
Cdd:COG4717   283 LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL 349
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 52-287 1.12e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.72  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   52 EKYQARIKGLNDRLKVQKKmySQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKA 131
Cdd:COG1196   223 KELEAELLLLKLRELEAEL--EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  132 ENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKS 211
Cdd:COG1196   301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  212 NDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQS 287
Cdd:COG1196   381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEE 456
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 941-1145 1.50e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 57.63  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKI-ETDLSnnlIAEIEKRNKKELEKTQELIDKYsafdEQEKQNILTRTKEKNDLRIKKEQ------ELNQKI 1013
Cdd:COG1579     3 PEDLRALLDLqELDSE---LDRLEHRLKELPAELAELEDEL----AALEARLEAAKTELEDLEKEIKRleleieEVEARI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1014 KELKEKAlsdGQISENE-----RKEIEKLEnqrrditvKELSKTEKEQERILVRmqrnrnaysIDEASKAIKEAEKARKA 1088
Cdd:COG1579    76 KKYEEQL---GNVRNNKeyealQKEIESLK--------RRISDLEDEILELMER---------IEELEEELAELEAELAE 135

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215401158 1089 RKKEVD---KQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKD--AVVDVVK 1145
Cdd:COG1579   136 LEAELEekkAELDEELAELEAELEELEAEREELAAKIPPELLALYERIRKRKNglAVVPVEG 197
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 45-259 1.76e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   45 DKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKL---VEANKKEKLALDKSKEAL 121
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALeaeLAELEKEIAELRAELEAQ 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  122 KSSNTELKKAenQYKRTNQRK-------QDAYQK------LKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALV 188
Cdd:COG4942   103 KEELAELLRA--LYRLGRQPPlalllspEDFLDAvrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELEALL 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158  189 EQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKA 259
Cdd:COG4942   181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 106-398 2.03e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 2.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   106 ANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQdayQKLKQLRDAEQklknsnqattaQLKRASDAVQKQSAKHK 185
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELEELE---EELEQLRKELE-----------ELSRQISALRKDLARLE 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   186 ALVEQYKQegnQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLE 265
Cdd:TIGR02168  740 AEVEQLEE---RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLN 816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   266 RSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIGDKMTSLGRTMtmgvsTPITLGLGAALKTSADFEGQMSR 345
Cdd:TIGR02168  817 EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI-----EELESELEALLNERASLEEALAL 891

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 215401158   346 VGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEA 398
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER 944
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 23-281 3.71e-08

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 56.19  E-value: 3.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    23 MKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLkvqkkmySQVEDELKQVNanyqkakssvKDVEKAYLK 102
Cdd:pfam00261    3 MQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRI-------QLLEEELERTE----------ERLAEALEK 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   103 LVEANKkeklALDKSKEALKS-SNTELK------KAENQYKRTNQRKQDAyqkLKQLRDAEQKLKnsnqATTAQLKRASD 175
Cdd:pfam00261   66 LEEAEK----AADESERGRKVlENRALKdeekmeILEAQLKEAKEIAEEA---DRKYEEVARKLV----VVEGDLERAEE 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   176 AVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEkefndlnntiknhsANVAKAETAVN 255
Cdd:pfam00261  135 RAELAESKIVELEEELKVVGNNLKSLEASEEKASEREDKYEEQIRFLTEKLKEAE--------------TRAEFAERSVQ 200

                          250       260
                   ....*....|....*....|....*.
gi 215401158   256 KEKAALNNLERSIDKASSEMKTFNKE 281
Cdd:pfam00261  201 KLEKEVDRLEDELEAEKEKYKAISEE 226
PTZ00121 PTZ00121
MAEBL; Provisional
 908-1208 3.75e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 3.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  908 SKETEKALEKYVHYSEENSRIMEKVRLNSGQISED--KAKKLLKIEtdlsnnliaeiEKRNKKELEKTQELidkySAFDE 985
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEarKADELKKAE-----------EKKKADEAKKAEEK----KKADE 1306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  986 QEKQnilTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKlenqrrdiTVKELSKTEKEQERilVRMQR 1065
Cdd:PTZ00121 1307 AKKK---AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA--------AADEAEAAEEKAEA--AEKKK 1373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1066 NRNAYSIDEASKAIKEAEKARKARKK-EVDKQYEDDViaikNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVV 1144
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEAKKKaEEDKKKADEL----KKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215401158 1145 KKQNKDIDKEMDLSSgrvyKNTEKwwngLKSWWSNFREDQKKKSDKYAKEQEETARRNRENIKK 1208
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKK----KAEEA----KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA 1505
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 912-1132 6.19e-08

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 56.85  E-value: 6.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   912 EKALEKYVHYSEENSRIMEKVRLnsgQISEDKAKKLLKIE--TDLSNNLIAEIEKRNK-KELEKTQELID---------- 978
Cdd:pfam13868   87 QKRQEEYEEKLQEREQMDEIVER---IQEEDQAEAEEKLEkqRQLREEIDEFNEEQAEwKELEKEEEREEderileylke 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   979 ---KYSAFDEQEKQNILTRTKEKNDLRikKEQELNQKIKELKEKALSDGQISENER----KEIEKLENQRRDitVKELSK 1051
Cdd:pfam13868  164 kaeREEEREAEREEIEEEKEREIARLR--AQQEKAQDEKAERDELRAKLYQEEQERkerqKEREEAEKKARQ--RQELQQ 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1052 TEKEQERILVRMQRnrnaysideaskaiKEAEKARKARKKEVDKQYEDDVIAIKNNvnlsksEKDKLLaiaDQRHKDEVR 1131
Cdd:pfam13868  240 AREEQIELKERRLA--------------EEAEREEEEFERMLRKQAEDEEIEQEEA------EKRRMK---RLEHRRELE 296


                   .
gi 215401158  1132 K 1132
Cdd:pfam13868  297 K 297
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 11-275 7.32e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.13  E-value: 7.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    11 ELKLDHLGVQEGMKGLKRQLGVVNSEMKANLSAfdkSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAK 90
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCADLQSKERL---KQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLE 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    91 SSVKDVekayLKLVEANKKEKLALDKskeALKSSNTELKKAENQYKRTNQRKQDayqklKQLRDAEQKLKNSNQATTAQL 170
Cdd:TIGR00606  468 GSSDRI----LELDQELRKAERELSK---AEKNSLTETLKKEVKSLQNEKADLD-----RKLRKLDQEMEQLNHHTTTRT 535

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   171 KRASDAVQKQSA-------KHKALVEQYKQEGNQVQKLKVQNDNLSKSNDK--IESSYAKTNTKLKQTEKEFNDLNNTIK 241
Cdd:TIGR00606  536 QMEMLTKDKMDKdeqirkiKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEInqTRDRLAKLNKELASLEQNKNHINNELE 615

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 215401158   242 NHSANVAKAETAV------NKEKAALNNLERSIDKASSEM 275
Cdd:TIGR00606  616 SKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQR 655
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 938-1209 7.37e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 58.06  E-value: 7.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   938 QISEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQelidkysafdEQEKQNILTRTKEKNDLRIKKEQELNQKIKE-- 1015
Cdd:pfam02463  146 IIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEET----------ENLAELIIDLEELKLQELKLKEQAKKALEYYql 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1016 -LKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERIlvrmqrnrnaysIDEASKAIKEAEKARKARKKEVD 1094
Cdd:pfam02463  216 kEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEI------------EKEEEKLAQVLKENKEEEKEKKL 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1095 KQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEKWWNGLK 1174
Cdd:pfam02463  284 QEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEK 363

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 215401158  1175 swwsNFREDQKKKSDKYAKEQEETARRNRENIKKW 1209
Cdd:pfam02463  364 ----LQEKLEQLEEELLAKKKLESERLSSAAKLKE 394
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 55-282 7.88e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 7.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   55 QARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKaylklveankkeklALDKSKEALKSSNTELKKAENQ 134
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER--------------RIAALARRIRALEQELAALEAE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  135 YKRTNQRKQDAYQKLKQLRDAEQKL-----KNSNQATTAQLKRASDAvqKQSAKHKALVEQYKQE-GNQVQKLKVQNDNL 208
Cdd:COG4942    85 LAELEKEIAELRAELEAQKEELAELlralyRLGRQPPLALLLSPEDF--LDAVRRLQYLKYLAPArREQAEELRADLAEL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215401158  209 SKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQ 282
Cdd:COG4942   163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
923-1208 8.65e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.77  E-value: 8.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  923 EENSRIMEKVRLNSGQISEDKaKKLLKIETDLSNNLIaEIEKrnkkELEKTQELIDKYSAFDEQEkqNILTRTKEKNDLR 1002
Cdd:PRK03918  448 EHRKELLEEYTAELKRIEKEL-KEIEEKERKLRKELR-ELEK----VLKKESELIKLKELAEQLK--ELEEKLKKYNLEE 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1003 IKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITvKELSKTEKEQERILVRMqRNRNAYSIDEASKAIKEA 1082
Cdd:PRK03918  520 LEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELE-KKLDELEEELAELLKEL-EELGFESVEELEERLKEL 597

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1083 EKARKARKKEVDKQYEddviaIKNNVNLSKSEKDKLlaiadqrhkDEVRKAKSKKDAVVDVVKKQNKDIDKEMD------ 1156
Cdd:PRK03918  598 EPFYNEYLELKDAEKE-----LEREEKELKKLEEEL---------DKAFEELAETEKRLEELRKELEELEKKYSeeeyee 663

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158 1157 -----LSSGRVYKNTEKWWNGLKSwwsnfREDQKKKSDKYAKEQEETARRNRENIKK 1208
Cdd:PRK03918  664 lreeyLELSRELAGLRAELEELEK-----RREEIKKTLEKLKEELEEREKAKKELEK 715
PTZ00121 PTZ00121
MAEBL; Provisional
 892-1241 9.46e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 9.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  892 ASKKASDTVKVLGKGVSKETEKALEkyVHYSEENSRIMEKVRLNSGQISED--KAKKLLKIETDLSnnliaEIEKRNKKE 969
Cdd:PTZ00121 1120 AKKKAEDARKAEEARKAEDARKAEE--ARKAEDAKRVEIARKAEDARKAEEarKAEDAKKAEAARK-----AEEVRKAEE 1192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  970 LEKTQEL--IDKYSAFDEQEKQNILTRTKEKNDLR-IKKEQELNQKIKELK--EKALSDGQISENERKEIEKLENQRRDI 1044
Cdd:PTZ00121 1193 LRKAEDArkAEAARKAEEERKAEEARKAEDAKKAEaVKKAEEAKKDAEEAKkaEEERNNEEIRKFEEARMAHFARRQAAI 1272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1045 TVKELSKTEK----EQERILVRMQRNRNAYSIDEASKAIKEAEKARKARKK---------EVDKQYEDDVIAIKNNVNLS 1111
Cdd:PTZ00121 1273 KAEEARKADElkkaEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKaeeakkkadAAKKKAEEAKKAAEAAKAEA 1352

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1112 KSEKDKLLAIADQRHKDEVRKAKSKKDAvvDVVKKQNKDIDKEMDLSsgRVYKNTEKWWNGLKSwwsnfREDQKKKSDKY 1191
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAEKKKEEAKKKA--DAAKKKAEEKKKADEAK--KKAEEDKKKADELKK-----AAAAKKKADEA 1423

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 215401158 1192 AKEQEETARRNRENIKKWFGNAWDGVKSKTGEAfsKMGRNANHFGGEMKK 1241
Cdd:PTZ00121 1424 KKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA--KKAEEAKKKAEEAKK 1471
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 26-414 1.16e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 57.44  E-value: 1.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    26 LKRQLGVVNSEMKaNLSAFDKSEKS-----MEKYQARIKGLNDRLKVQKKMYSQVEdelkqvnanyqkaksSVKDVEKay 100
Cdd:pfam15921  417 LRRELDDRNMEVQ-RLEALLKAMKSecqgqMERQMAAIQGKNESLEKVSSLTAQLE---------------STKEMLR-- 478

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   101 lKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTN-------QRKQDAYQKLKQLRDAEQKLKNSN---QATTAQL 170
Cdd:pfam15921  479 -KVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNaeitklrSRVDLKLQELQHLKNEGDHLRNVQtecEALKLQM 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   171 KRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKS-NDK------IESSYAKTNTKLKQTEKEFNDLN-NTIK- 241
Cdd:pfam15921  558 AEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEiNDRrlelqeFKILKDKKDAKIRELEARVSDLElEKVKl 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   242 -NHSANVAKAETAVNKEKAALNN------------------LERSIDKASSEMK-TFNKEQMIAQSHFGKLASQADVMSK 301
Cdd:pfam15921  638 vNAGSERLRAVKDIKQERDQLLNevktsrnelnslsedyevLKRNFRNKSEEMEtTTNKLKMQLKSAQSELEQTRNTLKS 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   302 KFSSIGDKMtslgrTMTMGVSTPITLGLGA--ALKTSADF-EGQMSRvgaiAQASSKDLKSMSNQavdLGAKTSKSANEV 378
Cdd:pfam15921  718 MEGSDGHAM-----KVAMGMQKQITAKRGQidALQSKIQFlEEAMTN----ANKEKHFLKEEKNK---LSQELSTVATEK 785

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 215401158   379 AKGMEELAALGFNAKQTMEAMPGVISAAEASGAEMA 414
Cdd:pfam15921  786 NKMAGELEVLRSQERRLKEKVANMEVALDKASLQFA 821
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
909-1159 1.46e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  909 KETEKALEKYVHYSEENSRIMEKVRlnsgqisedKAKKLLKIETDLSNNLIAEIEKRNKKE------LEKTQELIDKYSA 982
Cdd:PRK03918  286 KELKEKAEEYIKLSEFYEEYLDELR---------EIEKRLSRLEEEINGIEERIKELEEKEerleelKKKLKELEKRLEE 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  983 FDE------------QEKQNILTRTKEKNDLRIKKE--------QELNQKIKELKEKALSDGQISENERKEIEKLENQRR 1042
Cdd:PRK03918  357 LEErhelyeeakakkEELERLKKRLTGLTPEKLEKEleelekakEEIEEEISKITARIGELKKEIKELKKAIEELKKAKG 436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1043 DITV--KELskTEKEQERILVRMQRNRNaySIDEASKAIKEAEKARKARKKEVDK--QYEDDVIAIKNNVNLSKSEKDKL 1118
Cdd:PRK03918  437 KCPVcgREL--TEEHRKELLEEYTAELK--RIEKELKEIEEKERKLRKELRELEKvlKKESELIKLKELAEQLKELEEKL 512

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 215401158 1119 LAIADQ---RHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSS 1159
Cdd:PRK03918  513 KKYNLEeleKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKK 556
PTZ00121 PTZ00121
MAEBL; Provisional
 47-260 1.57e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   47 SEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV----NANYQKAKSSVKDVEKAYLKLVEANKKEKLAlDKSKEALK 122
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAeekkKADEAKKAEEKKKADEAKKKAEEAKKADEAK-KKAEEAKK 1329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  123 SSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKA-----LVEQYKQEGNQ 197
Cdd:PTZ00121 1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeakkKAEEDKKKADE 1409

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  198 VQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDlnnTIKNHSANVAKAETAVNKEKAA 260
Cdd:PTZ00121 1410 LKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD---EAKKKAEEAKKAEEAKKKAEEA 1469
PTZ00121 PTZ00121
MAEBL; Provisional
 36-296 1.78e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   36 EMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKmysQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKlALD 115
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEA---KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAE-AKK 1510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  116 KSKEALKSSNT----ELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQY 191
Cdd:PTZ00121 1511 KADEAKKAEEAkkadEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE 1590

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  192 KQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKE------KAALNNLE 265
Cdd:PTZ00121 1591 EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEeenkikAAEEAKKA 1670

                         250       260       270
                  ....*....|....*....|....*....|.
gi 215401158  266 RSIDKASSEMKTFNKEQMIAQSHFGKLASQA 296
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAAEALKKEAEEA 1701
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 26-282 1.86e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.57  E-value: 1.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    26 LKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKakssvkdVEKAYLKLVE 105
Cdd:TIGR04523  361 KQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKEL-------LEKEIERLKE 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   106 ANKKEKlaldKSKEALKSSNTELKKaenQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRasdavqkQSAKHK 185
Cdd:TIGR04523  434 TIIKNN----SEIKDLTNQDSVKEL---IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKS-------KEKELK 499

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   186 ALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNhsANVAKAETAVNKE----KAAL 261
Cdd:TIGR04523  500 KLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKK--ENLEKEIDEKNKEieelKQTQ 577

                          250       260
                   ....*....|....*....|....*...
gi 215401158   262 NNLERS-------IDKASSEMKTFNKEQ 282
Cdd:TIGR04523  578 KSLKKKqeekqelIDQKEKEKKDLIKEI 605
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 52-281 1.96e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 1.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    52 EKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAyLKLVEANKKEKlaldksKEALKSSNTELKKA 131
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKE-LTNSESENSEK------QRELEEKQNEIEKL 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   132 ENQykrtNQRKQDAYQKLK-QLRDAEQKLKNSNQattaqlkrasDAVQKQSaKHKALVEQYKQEGNQVQKLKVQNdnlSK 210
Cdd:TIGR04523  376 KKE----NQSYKQEIKNLEsQINDLESKIQNQEK----------LNQQKDE-QIKKLQQEKELLEKEIERLKETI---IK 437

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158   211 SNDKIESSYAKTNTKlkqtEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKE 281
Cdd:TIGR04523  438 NNSEIKDLTNQDSVK----ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEE 504
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
55-234 2.31e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   55 QARIKGLNDRLKvqkkmysQVEDELKQVNANYQKAKSSVKDVEK---AYLKLVEAN---------KKEKLALDKSKEALK 122
Cdd:COG4913   609 RAKLAALEAELA-------ELEEELAEAEERLEALEAELDALQErreALQRLAEYSwdeidvasaEREIAELEAELERLD 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  123 SSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQ-----KQSAKHKALVEQYKQEG-- 195
Cdd:COG4913   682 ASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaaedlARLELRALLEERFAAALgd 761

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 215401158  196 NQVQKLKvqnDNLSKSNDKIESSYAKTNTKLKQTEKEFN 234
Cdd:COG4913   762 AVERELR---ENLEERIDALRARLNRAEEELERAMRAFN 797
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 891-1202 3.86e-07

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 55.40  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  891 TASKKASDTVKVLGKGVSKETEKALEKyVHYSEENSRIMEKVRLNsgqisedkaKKLLKIETDLSNNLIAEIEKRNKKEL 970
Cdd:NF033838   47 TVTSSGNESQKEHAKEVESHLEKILSE-IQKSLDKRKHTQNVALN---------KKLSDIKTEYLYELNVLKEKSEAELT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  971 EKTQELIDkySAFdEQEKQNILTRTKEKNDLRiKKEQELNQKIKELKEKALSDgqISENERKEIEkLENQRRDITVKEls 1050
Cdd:NF033838  117 SKTKKELD--AAF-EQFKKDTLEPGKKVAEAT-KKVEEAEKKAKDQKEEDRRN--YPTNTYKTLE-LEIAESDVEVKK-- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1051 kteKEQERILVRMQRNRNAYSIDEAsKAIKEAEKARKARKKEV--DKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKD 1128
Cdd:NF033838  188 ---AELELVKEEAKEPRDEEKIKQA-KAKVESKKAEATRLEKIktDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKR 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158 1129 EVRKAKSKKDAVVDvvKKQNKDidKEMDLSSGRVYKNTEKWWNGLKSwwsnfREDQKKK--SDKYAKEQEETARRN 1202
Cdd:NF033838  264 RAKRGVLGEPATPD--KKENDA--KSSDSSVGEETLPSPSLKPEKKV-----AEAEKKVeeAKKKAKDQKEEDRRN 330
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 922-1157 4.92e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 55.36  E-value: 4.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   922 SEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDL 1001
Cdd:pfam02463  792 KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQE 871

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1002 RIKKEQELNQKIKELKEKALSDGQisENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIDEASKAIKE 1081
Cdd:pfam02463  872 LLLKEEELEEQKLKDELESKEEKE--KEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKE 949

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1082 AEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDL 1157
Cdd:pfam02463  950 KEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLEL 1025
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 910-1147 8.47e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  910 ETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQ 989
Cdd:COG1196   266 EAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  990 niLTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITvKELSKTEKEQERILVRMQRNRNA 1069
Cdd:COG1196   346 --LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA-AQLEELEEAEEALLERLERLEEE 422

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158 1070 ysIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVVKKQ 1147
Cdd:COG1196   423 --LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
72-274 9.46e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.15  E-value: 9.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   72 YSQVEDElKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKL--ALDKSKEALKSsnTELKKAENQYKRTNQRKQDAYQKL 149
Cdd:COG4913   214 REYMLEE-PDTFEAADALVEHFDDLERAHEALEDAREQIELlePIRELAERYAA--ARERLAELEYLRAALRLWFAQRRL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  150 KQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQ-EGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQ 228
Cdd:COG4913   291 ELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnGGDRLEQLEREIERLERELEERERRRARLEALLAA 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158  229 -------TEKEFNDLNNTIKNHSANVAKAETAVNKE----KAALNNLERSIDKASSE 274
Cdd:COG4913   371 lglplpaSAEEFAALRAEAAALLEALEEELEALEEAlaeaEAALRDLRRELRELEAE 427
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 907-1143 9.59e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.29  E-value: 9.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   907 VSKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKaKKLLKIETDL--SNNLIAEIEKR------NKKELEKTQELID 978
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-EEIEELQKELyaLANEISRLEQQkqilreRLANLERQLEELE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   979 KYSAFDEQEKQNILTR----TKEKNDLRIKKE------QELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITvKE 1048
Cdd:TIGR02168  323 AQLEELESKLDELAEElaelEEKLEELKEELEsleaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN-NE 401

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1049 LSKTEKEQERILVRMQRNRNaySIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQR--- 1125
Cdd:TIGR02168  402 IERLEARLERLEDRRERLQQ--EIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAlda 479

                          250
                   ....*....|....*...
gi 215401158  1126 HKDEVRKAKSKKDAVVDV 1143
Cdd:TIGR02168  480 AERELAQLQARLDSLERL 497
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
38-377 1.35e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 52.98  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   38 KANLSAFDKSEKSMEKyqarIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKaylKLVEANKKeklaLDKS 117
Cdd:COG4372    10 KARLSLFGLRPKTGIL----IAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEE---ELEQARSE----LEQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  118 KEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQ 197
Cdd:COG4372    79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  198 VQKL--KVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEM 275
Cdd:COG4372   159 LESLqeELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSAL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  276 KTFNKEQMIAQSH-FGKLASQADVMSKKFSSIGDKMTSLGRTMTMGVSTPITLGLGAALKTSADFEGQMSRVGAIAQASS 354
Cdd:COG4372   239 LDALELEEDKEELlEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALL 318

                         330       340
                  ....*....|....*....|...
gi 215401158  355 KDLKSMSNQAVDLGAKTSKSANE 377
Cdd:COG4372   319 AALLELAKKLELALAILLAELAD 341
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 908-1200 1.60e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   908 SKETEKAlEKYVHYSEENSRIMEKVRLNSGQISEdkaKKLLKIETDlsnnlIAEIEKrnkkELEKTQELIDKYSAFDEQE 987
Cdd:TIGR02169  204 RREREKA-ERYQALLKEKREYEGYELLKEKEALE---RQKEAIERQ-----LASLEE----ELEKLTEEISELEKRLEEI 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKEKNDLRIKKEQELNQKIKELK-EKALSDGQISENERkEIEKLENQRRdITVKELSKTEKEQERILVRMQR- 1065
Cdd:TIGR02169  271 EQLLEELNKKIKDLGEEEQLRVKEKIGELEaEIASLERSIAEKER-ELEDAEERLA-KLEAEIDKLLAEIEELEREIEEe 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1066 NRNAYSIDEASKAIKEAEKARKARKKEVD----------KQYEDDVIAIKNNVNLSKSEKDKLLAIADQRH------KDE 1129
Cdd:TIGR02169  349 RKRRDKLTEEYAELKEELEDLRAELEEVDkefaetrdelKDYREKLEKLKREINELKRELDRLQEELQRLSeeladlNAA 428

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215401158  1130 VRKAKSKKDAVVDVVKKQNKDIDK-EMDLSSGRVYKNTEkwwnglKSWWSNFREDQKKKSDKYAKEQEETAR 1200
Cdd:TIGR02169  429 IAGIEAKINELEEEKEDKALEIKKqEWKLEQLAADLSKY------EQELYDLKEEYDRVEKELSKLQRELAE 494
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1-281 2.15e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 2.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     1 MNEKVEGMTLELKLDHLGVQEGM---KGLKRQLGV-------VNSEMKANLSAFDKSEKS----MEKYQARIKGLNDRLK 66
Cdd:pfam05483  287 LIEKKDHLTKELEDIKMSLQRSMstqKALEEDLQIatkticqLTEEKEAQMEELNKAKAAhsfvVTEFEATTCSLEELLR 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    67 VQKKMYSQVEDELKQVNANYQKAKSSV---------KDVEKAYLKLVEANKK----EKLALDKSKEALKSSNTEL----- 128
Cdd:pfam05483  367 TEQQRLEKNEDQLKIITMELQKKSSELeemtkfknnKEVELEELKKILAEDEklldEKKQFEKIAEELKGKEQELifllq 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   129 ------KKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLK 202
Cdd:pfam05483  447 arekeiHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCK 526

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   203 VQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIK-----------NHSANVAKAETAVNKEKAALNNLERSIDKA 271
Cdd:pfam05483  527 KQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKckldkseenarSIEYEVLKKEKQMKILENKCNNLKKQIENK 606

                          330
                   ....*....|
gi 215401158   272 SSEMKTFNKE 281
Cdd:pfam05483  607 NKNIEELHQE 616
PTZ00121 PTZ00121
MAEBL; Provisional
 19-275 2.35e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 2.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSE--KSMEKYQARIKGLNDRLKVQKKMYSQV--EDELKQVNANyQKAKSSVK 94
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEelKKAEEEKKKVEQLKKKEAEEKKKAEELkkAEEENKIKAA-EEAKKAEE 1672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   95 DVEKAylklvEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAyqklKQLRDAEQKlknsNQATTAQLKRAS 174
Cdd:PTZ00121 1673 DKKKA-----EEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA----EELKKAEEE----NKIKAEEAKKEA 1739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  175 DAVQKQSAKHKalVEQykQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKlKQTEKEFNDLNNTIKNHSANVAKAETAV 254
Cdd:PTZ00121 1740 EEDKKKAEEAK--KDE--EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELD-EEDEKRRMEVDKKIKDIFDNFANIIEGG 1814

                         250       260
                  ....*....|....*....|.
gi 215401158  255 NKEKAALNNLERSIDKASSEM 275
Cdd:PTZ00121 1815 KEGNLVINDSKEMEDSAIKEV 1835
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1-266 2.91e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.83  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    1 MNEKVEGMTLELKLDHLGVQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELK 80
Cdd:COG4372     4 LGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   81 QVNANYQKAKSSVKDVEKAylklVEANKKEKLALDKSKEALKSSNTELKKAENQYKRT-NQRKQDAYQKLKQLRDAEQKL 159
Cdd:COG4372    84 ELNEQLQAAQAELAQAQEE----LESLQEEAEELQEELEELQKERQDLEQQRKQLEAQiAELQSEIAEREEELKELEEQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  160 kNSNQATTAQLKRASDAVQKQSAKHKalVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNT 239
Cdd:COG4372   160 -ESLQEELAALEQELQALSEAEAEQA--LDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALS 236

                         250       260
                  ....*....|....*....|....*..
gi 215401158  240 IKNHSANVAKAETAVNKEKAALNNLER 266
Cdd:COG4372   237 ALLDALELEEDKEELLEEVILKEIEEL 263
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 50-316 3.28e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.33  E-value: 3.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    50 SMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELK 129
Cdd:TIGR04523  205 NLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIK 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   130 KAENQYKR--------TNQRKQDAYQKLK-QLRDAEQKLKNsnqattaqlkrasdaVQKQSAKHKALVEQYKQegnQVQK 200
Cdd:TIGR04523  285 ELEKQLNQlkseisdlNNQKEQDWNKELKsELKNQEKKLEE---------------IQNQISQNNKIISQLNE---QISQ 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   201 LKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNK 280
Cdd:TIGR04523  347 LKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEK 426

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 215401158   281 EQMIAQSHFGKLASQADVMSKKFSSIGDKMTSLGRT 316
Cdd:TIGR04523  427 EIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNT 462
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 922-1118 3.86e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.03  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   922 SEENSRIMEKVRLnsgqisedKAKKLLKIETDLSNNLIAEIEKRNK--KELEKTQELIDKYSAfDEQEKQNILTRTKEKN 999
Cdd:pfam05483  571 SEENARSIEYEVL--------KKEKQMKILENKCNNLKKQIENKNKniEELHQENKALKKKGS-AENKQLNAYEIKVNKL 641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1000 DLRIKKEQELNQKIKELKEKALSDGQIS-ENERKEIEKLEnqrrdITVKELSKTEKE-----QERI---LVRMQRNRNAY 1070
Cdd:pfam05483  642 ELELASAKQKFEEIIDNYQKEIEDKKISeEKLLEEVEKAK-----AIADEAVKLQKEidkrcQHKIaemVALMEKHKHQY 716

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1071 S--IDEASKAI-----KEAEKARKARKKEVD-KQYEDDVIAIKNNVNLSKSEKDKL 1118
Cdd:pfam05483  717 DkiIEERDSELglyknKEQEQSSAKAALEIElSNIKAELLSLKKQLEIEKEEKEKL 772
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 893-1168 4.38e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.03  E-value: 4.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   893 SKKASDTVKVLGKGVSKETEkaLEKYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNN--LIAEIEKRN---- 966
Cdd:pfam05483   81 SKLYKEAEKIKKWKVSIEAE--LKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENkdLIKENNATRhlcn 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   967 --KKELEKTQELIDKYSAFDEQEKQ-------NILTRTKEKNDLRIKKEQ---ELNQKIKELKEKAlsdGQISENERKEI 1034
Cdd:pfam05483  159 llKETCARSAEKTKKYEYEREETRQvymdlnnNIEKMILAFEELRVQAENarlEMHFKLKEDHEKI---QHLEEEYKKEI 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1035 EKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSE 1114
Cdd:pfam05483  236 NDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKAL 315

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  1115 KDKL---------LAIADQRHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEK 1168
Cdd:pfam05483  316 EEDLqiatkticqLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQ 378
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
941-1204 4.51e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDLsNNLIAEIEKRNKKElEKTQELIDKysafDEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEka 1020
Cdd:PRK03918  161 ENAYKNLGEVIKEI-KRRIERLEKFIKRT-ENIEELIKE----KEKELEEVLREINEISSELPELREELEKLEKEVKE-- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1021 lsdgqiSENERKEIEKLEnqrrditvKELSKTEKEQERILVRMQRNRNaySIDEASKAIKEAEKARKARK--KEVDKQYE 1098
Cdd:PRK03918  233 ------LEELKEEIEELE--------KELESLEGSKRKLEEKIRELEE--RIEELKKEIEELEEKVKELKelKEKAEEYI 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1099 dDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAK--SKKDAVVDVVKKQNKDIDKEMDlssgrVYKNTEKWWNGLKSW 1176
Cdd:PRK03918  297 -KLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKelEEKEERLEELKKKLKELEKRLE-----ELEERHELYEEAKAK 370

                         250       260       270
                  ....*....|....*....|....*....|..
gi 215401158 1177 WSNFREDQKKKS----DKYAKEQEETARRNRE 1204
Cdd:PRK03918  371 KEELERLKKRLTgltpEKLEKELEELEKAKEE 402
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 1853-1913 5.12e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 45.48  E-value: 5.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158 1853 NIISLIQHESGGNAGItqssalrdiNVLQGNPAKGLLQYIPQTFRHYAVRGHNNIYSGYDQ 1913
Cdd:cd00442     1 VLAAIIGQESGGNKPA---------NAGSGSGAAGLFQFMPGTWKAYGKNSSSDLNDPEAS 52
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
28-277 6.82e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.22  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   28 RQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEAn 107
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEEL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  108 KKEKLALDKSKEAL-----------KSSNTELKKAENQYKRTNQRKQDA--YQKLKQLRDAEQKLKNSNQATTAQLKRAS 174
Cdd:PRK03918  244 EKELESLEGSKRKLeekireleeriEELKKEIEELEEKVKELKELKEKAeeYIKLSEFYEEYLDELREIEKRLSRLEEEI 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  175 DAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNtKLKQTEKEFNDLN-NTIKNHSANVAKAETA 253
Cdd:PRK03918  324 NGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKE-ELERLKKRLTGLTpEKLEKELEELEKAKEE 402

                         250       260
                  ....*....|....*....|....
gi 215401158  254 VNKEKAALNNLERSIDKASSEMKT 277
Cdd:PRK03918  403 IEEEISKITARIGELKKEIKELKK 426
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
24-315 7.62e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.22  E-value: 7.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   24 KGLKRQLgvvnSEMKANLSAFDKS---EKSMEKYQARIKG-----LNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKD 95
Cdd:PRK03918  348 KELEKRL----EELEERHELYEEAkakKEELERLKKRLTGltpekLEKELEELEKAKEEIEEEISKITARIGELKKEIKE 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   96 VEKAYLKLVEANKK-----EKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDA--------------------YQKLK 150
Cdd:PRK03918  424 LKKAIEELKKAKGKcpvcgRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLrkelrelekvlkkeseliklKELAE 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  151 QLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTE 230
Cdd:PRK03918  504 QLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELG 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  231 -KEFNDLNNTIKNHSANVAKAETAVNKEKaALNNLERSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFS----- 304
Cdd:PRK03918  584 fESVEELEERLKELEPFYNEYLELKDAEK-ELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSeeeye 662

                         330
                  ....*....|.
gi 215401158  305 SIGDKMTSLGR 315
Cdd:PRK03918  663 ELREEYLELSR 673
SpoIVFA COG5833
Stage IV sporulation protein SpoIVFA, regulates SpoIVFB [Cell cycle control, cell division, ...
 1707-1797 8.18e-06

Stage IV sporulation protein SpoIVFA, regulates SpoIVFB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444535 [Multi-domain]  Cd Length: 219  Bit Score: 49.22  E-value: 8.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1707 HYGIDFGMPSGTNVYAVKGGIADKVWTDYGGGNSIQIKTGANEWNWYMHLSKQLARQGQRIKAGQLIGKSGATGNfvRGA 1786
Cdd:COG5833   120 GKGVDIETPGGANVKAVKEGYVIFAGKDEETGKTVIIQHADGSESWYGNLSSIDVKLYDFVEAGQKIGTVPATEG--EEG 197

                          90
                  ....*....|.
gi 215401158 1787 HLHFQLMQGSH 1797
Cdd:COG5833   198 TFYFAIKKGGK 208
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 873-1175 8.21e-06

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 50.73  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  873 DLLKVGVNKFKGFMQTMGTASKKASDTVKVLGKGVSKETEKALEKYVHYSEENSRIMEKVRLNSGQisEDKAKKLLKIET 952
Cdd:COG5185   186 LGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQT--SDKLEKLVEQNT 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  953 DLSNNLIAEIEKRNKKELEKTQELIDKYsafdEQEKQNILTRTKEkndlrIKKEQELNQKIKELKEKALSDgQISENERK 1032
Cdd:COG5185   264 DLRLEKLGENAESSKRLNENANNLIKQF----ENTKEKIAEYTKS-----IDIKKATESLEEQLAAAEAEQ-ELEESKRE 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1033 EIEKLENQRRDITvKELSKTEKEQERILVRMQRNRNAYSIDEASKAIKEAEKARKARKKEVDKQYEDdvIAIKNNVNLSK 1112
Cdd:COG5185   334 TETGIQNLTAEIE-QGQESLTENLEAIKEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQN--QRGYAQEILAT 410

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215401158 1113 SEKDKLLAIAD-QRHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEKWWNGLKS 1175
Cdd:COG5185   411 LEDTLKAADRQiEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINR 474
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 909-1154 8.76e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 8.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   909 KETEKALEKYVHYSEENSRIMEKVRLNSGQIseDKAKKLLKIETDLSNNLIAEIEKRnKKELEKT-QELIDKYSafDEQE 987
Cdd:TIGR00618  166 KELLMNLFPLDQYTQLALMEFAKKKSLHGKA--ELLTLRSQLLTLCTPCMPDTYHER-KQVLEKElKHLREALQ--QTQQ 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKEKNDLRIKKEQELNQKIKELKEkalsdgqiSENERKEIEKLE---NQRRDIT-----VKELSKTEKEQERI 1059
Cdd:TIGR00618  241 SHAYLTQKREAQEEQLKKQQLLKQLRARIEE--------LRAQEAVLEETQeriNRARKAAplaahIKAVTQIEQQAQRI 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1060 LVRMQRNRN--AYSIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSksekdkLLAIADQRHKDE--VRKAKS 1135
Cdd:TIGR00618  313 HTELQSKMRsrAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATS------IREISCQQHTLTqhIHTLQQ 386

                          250
                   ....*....|....*....
gi 215401158  1136 KKDAVVDVVKKQNKDIDKE 1154
Cdd:TIGR00618  387 QKTTLTQKLQSLCKELDIL 405
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 41-315 9.62e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 9.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    41 LSAFDKSEKsmEKYQARIKGLNDRLKVQKKMYSQVEdelkqvNANYQKAKSSVKdvEKAYLKLVEANKKEKLAL---DKS 117
Cdd:TIGR00618  120 ILAAKKSET--EEVIHDLLKLDYKTFTRVVLLPQGE------FAQFLKAKSKEK--KELLMNLFPLDQYTQLALmefAKK 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   118 KEALKSSNTELKKAENQYKRTNQRKQDAYQK-------LKQLRDAEQKLknsnQATTAQLKRASDAVQKQSAKHKALVEQ 190
Cdd:TIGR00618  190 KSLHGKAELLTLRSQLLTLCTPCMPDTYHERkqvlekeLKHLREALQQT----QQSHAYLTQKREAQEEQLKKQQLLKQL 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   191 YKQEgnqvQKLKVQNDNLSKSNDKIESS-----YAKTNTKLKQTEKEFNDLNNTIKN----------HSANVAKAETAVN 255
Cdd:TIGR00618  266 RARI----EELRAQEAVLEETQERINRArkaapLAAHIKAVTQIEQQAQRIHTELQSkmrsrakllmKRAAHVKQQSSIE 341

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158   256 KEKAALNNL-------ERSIDKASSEMKTFNKEQMIAQsHFGKLASQADVMSKKFSSIGDKMTSLGR 315
Cdd:TIGR00618  342 EQRRLLQTLhsqeihiRDAHEVATSIREISCQQHTLTQ-HIHTLQQQKTTLTQKLQSLCKELDILQR 407
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 45-281 9.98e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.79  E-value: 9.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    45 DKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEanKKEKLALDKSK--EALK 122
Cdd:TIGR04523  464 ESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKE--KIEKLESEKKEkeSKIS 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   123 SSNTELKKAENQYKRTNQRKQ-DAYQK-LKQLRDAEQKLKNSNqattaqlKRASDAVQKQSAKHKALVEQYKQEGNQVQK 200
Cdd:TIGR04523  542 DLEDELNKDDFELKKENLEKEiDEKNKeIEELKQTQKSLKKKQ-------EEKQELIDQKEKEKKDLIKEIEEKEKKISS 614

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   201 LKVQNDNLSKSN-------DKIESSYAKTNTKLKQTEKEFndlnNTIKNHSAN-VAKAETAVNKekaalnnlersIDKAS 272
Cdd:TIGR04523  615 LEKELEKAKKENeklssiiKNIKSKKNKLKQEVKQIKETI----KEIRNKWPEiIKKIKESKTK-----------IDDII 679


                   ....*....
gi 215401158   273 SEMKTFNKE 281
Cdd:TIGR04523  680 ELMKDWLKE 688
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 901-1057 1.00e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 1.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   901 KVLGKGVSKETEKALEKYVH-YSEENSRIMEKVRLNS-----------GQISEDKAKKLLK-----------------IE 951
Cdd:pfam17380  419 KVEMEQIRAEQEEARQREVRrLEEERAREMERVRLEEqerqqqverlrQQEEERKRKKLELekekrdrkraeeqrrkiLE 498

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   952 TDLSNNLIAEIEKRNK-KELEKtqELIDKYSAFDEQEKqniltRTKEKNDLRIKKEQELNQKIKELKEKAlsdgqisENE 1030
Cdd:pfam17380  499 KELEERKQAMIEEERKrKLLEK--EMEERQKAIYEEER-----RREAEEERRKQQEMEERRRIQEQMRKA-------TEE 564

                          170       180
                   ....*....|....*....|....*...
gi 215401158  1031 RKEIEKLENQRRDI-TVKELSKTEKEQE 1057
Cdd:pfam17380  565 RSRLEAMEREREMMrQIVESEKARAEYE 592
PRK06148 PRK06148
hypothetical protein; Provisional
 1706-1792 1.15e-05

hypothetical protein; Provisional


Pssm-ID: 180426 [Multi-domain]  Cd Length: 1013  Bit Score: 50.79  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1706 RHYGIDFGMPSGTNVYAvkgGIADKVWT--------DYGGGNSIQIKT--GANEWNWYMHLSKQ-LAR--QGQRIKAGQL 1772
Cdd:PRK06148  440 VHLGVDLFAPAGTPVYA---PLAGTVRSveieavplGYGGLVALEHETpgGDPFYTLYGHLAHEaVSRlkPGDRLAAGEL 516

                          90       100
                  ....*....|....*....|.
gi 215401158 1773 IGKSGATG-NFVRGAHLHFQL 1792
Cdd:PRK06148  517 FGAMGDAHeNGGWAPHLHFQL 537
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 27-281 1.21e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 50.82  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    27 KRQLGVVNSEMKANLsaFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDV---EKAYLKL 103
Cdd:TIGR00606  724 RRDEMLGLAPGRQSI--IDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimERFQMEL 801

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   104 VEANKKeklaldKSKEALKSSNTELKKAENQYKRTNQRKQDAYQK-------LKQLRDAEQKLKNSNQATTAQLKRASDA 176
Cdd:TIGR00606  802 KDVERK------IAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTvvskielNRKLIQDQQEQIQHLKSKTNELKSEKLQ 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   177 VQKQSAKHKALVEQYKQEGNQVQKL---------KVQNDNLSKSNDKIESSY--AKTNTKLKQTEKEFNDLNNTIKN--- 242
Cdd:TIGR00606  876 IGTNLQRRQQFEEQLVELSTEVQSLireikdakeQDSPLETFLEKDQQEKEEliSSKETSNKKAQDKVNDIKEKVKNihg 955

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 215401158   243 HSANVAK------------AETAVNKEKAALNNLERSIDKASSEMKTFNKE 281
Cdd:TIGR00606  956 YMKDIENkiqdgkddylkqKETELNTVNAQLEECEKHQEKINEDMRLMRQD 1006
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 923-1139 1.23e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.71  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  923 EENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQ--NILTRTKEKND 1000
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAllEAEAELAEAEE 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1001 LRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIDEASKAIK 1080
Cdd:COG1196   380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1081 EAEKARKARKKEvDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQR-HKDEVRKAKSKKDA 1139
Cdd:COG1196   460 ALLELLAELLEE-AALLEAALAELLEELAEAAARLLLLLEAEADYeGFLEGVKAALLLAG 518
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
26-230 1.31e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   26 LKRQLGvvnsEMKANLsafDKSEKSMEKYQAR--IKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAylkl 103
Cdd:COG3206   180 LEEQLP----ELRKEL---EEAEAALEEFRQKngLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQ---- 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  104 vEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLR----DAEQKLKNSNQATTAQLKRASDAVQK 179
Cdd:COG3206   249 -LGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRaqiaALRAQLQQEAQRILASLEAELEALQA 327

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 215401158  180 QSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTE 230
Cdd:COG3206   328 REASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEAR 378
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 941-1153 1.59e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.02  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   941 EDKAKKLLKIETDLSNN---------LIAEIEK----------RNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDL 1001
Cdd:TIGR04523  317 KNQEKKLEEIQNQISQNnkiisqlneQISQLKKeltnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDL 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1002 RIK------KEQELNQKIKEL-KEKALSDGQIS------ENERKEIEKLENQ--RRDITVKELSKTEKEQERIL--VRMQ 1064
Cdd:TIGR04523  397 ESKiqnqekLNQQKDEQIKKLqQEKELLEKEIErlketiIKNNSEIKDLTNQdsVKELIIKNLDNTRESLETQLkvLSRS 476

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1065 RNRNAYSIDEASKAIKEAEKARKARKKEVdKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRH------KDEVRKAKS--K 1136
Cdd:TIGR04523  477 INKIKQNLEQKQKELKSKEKELKKLNEEK-KELEEKVKDLTKKISSLKEKIEKLESEKKEKEskisdlEDELNKDDFelK 555

                          250
                   ....*....|....*..
gi 215401158  1137 KDAVVDVVKKQNKDIDK 1153
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEE 572
46 PHA02562
endonuclease subunit; Provisional
 41-281 1.70e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 50.01  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   41 LSAFDKSEKSmekyqaRIKGLNDRLKVQKKMYSQVEDELK--QVNANYQKAKSS--VKDVEKAYLKLVEANKKEKLALDK 116
Cdd:PHA02562  165 LSEMDKLNKD------KIRELNQQIQTLDMKIDHIQQQIKtyNKNIEEQRKKNGenIARKQNKYDELVEEAKTIKAEIEE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  117 SKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLrDAEQKLKNSNQ---ATTAQLKRASDAVQKQSAKHKALVEQYKQ 193
Cdd:PHA02562  239 LTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQF-QKVIKMYEKGGvcpTCTQQISEGPDRITKIKDKLKELQHSLEK 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  194 EGNQVQKLKVQNDnlsksndkiessyaktntKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASS 273
Cdd:PHA02562  318 LDTAIDELEEIMD------------------EFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAE 379


                  ....*...
gi 215401158  274 EMKTFNKE 281
Cdd:PHA02562  380 ELAKLQDE 387
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 11-213 1.71e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   11 ELKLDHLGVQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDEL-KQVNANYQKA 89
Cdd:COG4942    45 ALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALyRLGRQPPLAL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   90 KSSVKDVEKA-----YLKLVEANKKEKLaldkskEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQ 164
Cdd:COG4942   125 LLSPEDFLDAvrrlqYLKYLAPARREQA------EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQ 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 215401158  165 ATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSND 213
Cdd:COG4942   199 KLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
PTZ00121 PTZ00121
MAEBL; Provisional
 42-231 1.84e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   42 SAFDKSEKSMEKYQArikglnDRLKVQKKmySQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEklALDKSKEAL 121
Cdd:PTZ00121 1354 AAADEAEAAEEKAEA------AEKKKEEA--KKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAA--AAKKKADEA 1423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  122 KSSNTELKKAENQYKRTNQRKQ--DAYQKLKQLRDAEQKLKNSNQATTAQ--LKRASDAVQKQSAKHKAlvEQYKQEGNQ 197
Cdd:PTZ00121 1424 KKKAEEKKKADEAKKKAEEAKKadEAKKKAEEAKKAEEAKKKAEEAKKADeaKKKAEEAKKADEAKKKA--EEAKKKADE 1501

                         170       180       190
                  ....*....|....*....|....*....|....
gi 215401158  198 VQKlkvQNDNLSKSNDKIESSYAKTNTKLKQTEK 231
Cdd:PTZ00121 1502 AKK---AAEAKKKADEAKKAEEAKKADEAKKAEE 1532
PTZ00121 PTZ00121
MAEBL; Provisional
 87-276 1.89e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   87 QKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQAT 166
Cdd:PTZ00121 1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKK 1309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  167 TAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKL-KVQNDNLSKSNDKIESSYAKTNTKLKQTEKEfNDLNNTIKNHSA 245
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAaEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA-KKKADAAKKKAE 1388

                         170       180       190
                  ....*....|....*....|....*....|.
gi 215401158  246 NVAKAETAVNKEKAALNNLERsIDKASSEMK 276
Cdd:PTZ00121 1389 EKKKADEAKKKAEEDKKKADE-LKKAAAAKK 1418
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 910-1094 2.25e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   910 ETEKA-LEKYVHYSEENSRIMEKvRLNSGQISEDKAKKllKIETDLSN-NLIAEIEKRNKKELE-KTQELIDKYSAFDEQ 986
Cdd:pfam01576  495 EDERNsLQEQLEEEEEAKRNVER-QLSTLQAQLSDMKK--KLEEDAGTlEALEEGKKRLQRELEaLTQQLEEKAAAYDKL 571

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   987 EKQNilTRTK-EKNDLRI-------------KKEQELNQKIKElkEKALSDGQISENERKEIEKLENQRRDITV----KE 1048
Cdd:pfam01576  572 EKTK--NRLQqELDDLLVdldhqrqlvsnleKKQKKFDQMLAE--EKAISARYAEERDRAEAEAREKETRALSLaralEE 647

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 215401158  1049 LSKTEKEQERI--LVRMQRNRNAYSIDEASKAIKEAEKARKARKKEVD 1094
Cdd:pfam01576  648 ALEAKEELERTnkQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVE 695
COG5412 COG5412
Phage-related protein [Mobilome: prophages, transposons];
248-867 2.69e-05

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 444167 [Multi-domain]  Cd Length: 704  Bit Score: 49.31  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  248 AKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQSHF----GKLASQADVMSKKFSSIGDKMTSLGRTMTMGVST 323
Cdd:COG5412     4 ADASAKEAASAALLLAQAKAADSELTAASGGVVSAAAKAQGSiaqlGKIGAAAGAEAALADSSLAFATLAAALGATVAGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  324 PITLGLGAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTME--AMPG 401
Cdd:COG5412    84 SLLLAAGGARAKGSAAAAAALGAVAAAAKVLNGALAAAGAALAATQALAAAATGAKGEANAAAKAGGAAALASAglAAAG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  402 VISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLArSANDSAADIQYMGDALKyAGTPAKALGVSIEDTSAAIE 481
Cdd:COG5412   164 AAAAASALAAAGAIAKAILSASKLSGQALAGQSAAAGGALE-AAAAAAAGAAAAGAAAA-AATAASALLALAALQGLAAG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  482 VLSNSGLEGSQAGTALRASFIRLANPSKNTAKEMKKLGIH-LSDAKGQFVGMGELIRQFQDNMKGMTREQKLAT-VATIV 559
Cdd:COG5412   242 AATGAAAGAAGAAGLGAAGAGAGQAAALLGLVAGAEASGGtAGGAVAGLAAGLAAAAGASANLGAAAAASFGASlAASAG 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  560 GTEAASGFLALIEAGPDKINSYSKSLKNSNGESKKAADLMKDNL--KGALEQLGGAFESLAIEVG---KDLTPMIRAG-- 632
Cdd:COG5412   322 VDTAAAALAAAEAIADGSLVAGLGSAGTVLSTLSGAVGGLEGAIgqLGAAGGLGSALGGLTGPIGiviAAIAALIAAFva 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  633 ----AEGLTKLVDG---FTHLPGWVRKASVGLALF---------------GAAIGPAVLAGGLLIRTVGSAAKGYASLNR 690
Cdd:COG5412   402 lwknSETFRNLVQGvweLNAIKTAIEGVVSAIVTFisalweaikalltaiGGALPQLIAAVWNGIVQFISAIITNLPLIL 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  691 RIAENTILS------NTNSKAMKSL-----GLQTLFLGSTTGKTSK----GFKGLAGAMMFNLKPI-NVLKNSAKLAILP 754
Cdd:COG5412   482 QAALQLIKAlikglwTAIKGVIQGAieiitGIIQFITALLTGDWSGiiweGIKQLVSGIVEIIPNIvAAVPQGGIAALWD 561

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  755 -----FKLLKNGLGLAAKSLFavSGGARFAGVALRFLTGPIGATITAITIAYKVFKTAYDR----VEWFRNGINGLGETI 825
Cdd:COG5412   562 aikgfFPGLIEAIVQLVSNII--NAIISIISSILNAAGSIISSIWNAIKSAVSSIISAKSIgkniVNGLWNGIKSAAGAV 639

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 215401158  826 KFFGGKIIGGAVRKLGEFKN------YLGSIGKSFKEKFSKDMKDGYK 867
Cdd:COG5412   640 TDKVKDIVGGIVDGIKGALGihspsrKFLEIGKMIVAGLAKGIEDAFS 687
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
948-1234 2.95e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.75  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  948 LKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAfDEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQIS 1027
Cdd:COG4372    18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLRE-ELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAEL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1028 ENERKEIEKLENQRRDITvKELSKTEKEQERIlvRMQRNRNAYSIDEASKAIKEAEKARKARKKEVDKQyEDDVIAIKNN 1107
Cdd:COG4372    97 AQAQEELESLQEEAEELQ-EELEELQKERQDL--EQQRKQLEAQIAELQSEIAEREEELKELEEQLESL-QEELAALEQE 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1108 VN-----LSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVVKKQNKDIDKEMDLSSGRVYKNTEKWWNGLKSWWSNFRE 1182
Cdd:COG4372   173 LQalseaEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELL 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 215401158 1183 DQKKKSDKYAKEQEETARRNRENIKKWFGNAWDGVKSKTGEAFSKMGRNANH 1234
Cdd:COG4372   253 EEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNL 304
PTZ00121 PTZ00121
MAEBL; Provisional
 23-276 3.52e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   23 MKGLKRQLGVVNSEMKANLSAFDKSE---KSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKA 99
Cdd:PTZ00121 1262 MAHFARRQAAIKAEEARKADELKKAEekkKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA 1341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  100 YLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKlkqlRDAEQKLKNSNQATtaqlKRASDAVQK 179
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEK----KKADEAKKKAEEDK----KKADELKKA 1413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  180 QSAKHKAlvEQYKQEGNQVQK---LKVQNDNLSKSND---KIESSYAKTNTKLKQTEKEFNDlnnTIKNHSANVAKAETA 253
Cdd:PTZ00121 1414 AAAKKKA--DEAKKKAEEKKKadeAKKKAEEAKKADEakkKAEEAKKAEEAKKKAEEAKKAD---EAKKKAEEAKKADEA 1488

                         250       260
                  ....*....|....*....|...
gi 215401158  254 VNKEKAALNNLERSIDKASSEMK 276
Cdd:PTZ00121 1489 KKKAEEAKKKADEAKKAAEAKKK 1511
PTZ00121 PTZ00121
MAEBL; Provisional
 35-283 4.03e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   35 SEMKANLSAFDKSEKSME----KYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSS------VKDVEKAYLKLV 104
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKadaaKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAkkkaeeKKKADEAKKKAE 1441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  105 EANKKEKLAlDKSKEALKSSNT-----------ELKKAENQYKRTNQRK---QDAYQKLKQLRDAEQKLKNSNQATTAQL 170
Cdd:PTZ00121 1442 EAKKADEAK-KKAEEAKKAEEAkkkaeeakkadEAKKKAEEAKKADEAKkkaEEAKKKADEAKKAAEAKKKADEAKKAEE 1520

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  171 KRASDAVQKQSAKHKALVEQYKQEGNQVQKLKvQNDNLSKSNDKiessyaktnTKLKQTEKEFNDLNNTIKnhsanvaKA 250
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELK-KAEELKKAEEK---------KKAEEAKKAEEDKNMALR-------KA 1583

                         250       260       270
                  ....*....|....*....|....*....|...
gi 215401158  251 ETAVNKEKAALnnleRSIDKASSEMKTFNKEQM 283
Cdd:PTZ00121 1584 EEAKKAEEARI----EEVMKLYEEEKKMKAEEA 1612
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 19-313 5.65e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.51  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    19 VQEGMKGLKRQLGVVNSEMkanlsafDKSEKSMEKyqarIKGLNDRLKVQKKMYSQVEDelKQVNANYQKAKSSvkdveK 98
Cdd:TIGR01612 1367 VKEYTKEIEENNKNIKDEL-------DKSEKLIKK----IKDDINLEECKSKIESTLDD--KDIDECIKKIKEL-----K 1428

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    99 AYLKLVEANKKE--KLALDKSKE-ALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQAttaqlKRASD 175
Cdd:TIGR01612 1429 NHILSEESNIDTyfKNADENNENvLLLFKNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGC-----KDEAD 1503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   176 AVQKQSAKHKALVEQYKQEG----NQVQKLKVQNDNLSKSND------KIESSYAKTNTKLKQTEKEFNDLNN---TIKN 242
Cdd:TIGR01612 1504 KNAKAIEKNKELFEQYKKDVtellNKYSALAIKNKFAKTKKDseiiikEIKDAHKKFILEAEKSEQKIKEIKKekfRIED 1583

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215401158   243 HSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQSHFGKLAS-QADVMSKKFSSIGDKMTSL 313
Cdd:TIGR01612 1584 DAAKNDKSNKAAIDIQLSLENFENKFLKISDIKKKINDCLKETESIEKKISSfSIDSQDTELKENGDNLNSL 1655
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
21-306 5.71e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 5.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   21 EGMKGLKRQLGVVNSEmkanlsafdKSEKSMEKYQarikGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAY 100
Cdd:PRK03918  503 EQLKELEEKLKKYNLE---------ELEKKAEEYE----KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELE 569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  101 LKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKnsnqATTAQLKRASDAVQKQ 180
Cdd:PRK03918  570 EELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELD----KAFEELAETEKRLEEL 645

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  181 SAKHKALVEQYKQEgnqvqklkvQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETA---VNKE 257
Cdd:PRK03918  646 RKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAkkeLEKL 716

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 215401158  258 KAALNNLERSIDKAsSEMKTFNKEQmiAQSHFGKLASQ--ADVMSKKFSSI 306
Cdd:PRK03918  717 EKALERVEELREKV-KKYKALLKER--ALSKVGEIASEifEELTEGKYSGV 764
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 3-282 5.78e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.43  E-value: 5.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     3 EKVEGMTLELKLDHLgvQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV 82
Cdd:pfam02463  221 LEEEYLLYLDYLKLN--EERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEEL 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    83 NANYQKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNS 162
Cdd:pfam02463  299 KSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAK 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   163 NQATTAQLKRAsdavqkqsakhKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNtikn 242
Cdd:pfam02463  379 KKLESERLSSA-----------AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQ---- 443

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 215401158   243 hsANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQ 282
Cdd:pfam02463  444 --GKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVK 481
TOPEUc smart00435
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ...
 48-145 6.21e-05

DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras


Pssm-ID: 214661 [Multi-domain]  Cd Length: 391  Bit Score: 47.73  E-value: 6.21e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     48 EKSMEKYQARIKGLNDRLKVQKKMYsqveDELKQVNANYQKAKSSV-KDVEKAYLKlVEANKKEKLALDKSKEALKSSNT 126
Cdd:smart00435  276 EKSMEKLQEKIKALKYQLKRLKKMI----LLFEMISDLKRKLKSKFeRDNEKLDAE-VKEKKKEKKKEEKKKKQIERLEE 350

                            90
                    ....*....|....*....
gi 215401158    127 ELKKAENQYKRTNQRKQDA 145
Cdd:smart00435  351 RIEKLEVQATDKEENKTVA 369
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 844-1197 6.68e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.51  E-value: 6.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   844 KNYLGSIGKSFKEK--------FSKDMKDGYKSLSDDDLLKVGVNKFKGFMQTMGTASKKasdtvKVLGKGVSKETEKAL 915
Cdd:TIGR01612  423 NNFHKTIERLIFEKpdpnnnniFKDDFDEFNKPIPKSKLKALEKRFFEIFEEEWGSYDIK-----KDIDENSKQDNTVKL 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   916 ekYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKrnkkELEKTQELIDKYsafdEQEKQNILTRT 995
Cdd:TIGR01612  498 --ILMRMKDFKDIIDFMELYKPDEVPSKNIIGFDIDQNIKAKLYKEIEA----GLKESYELAKNW----KKLIHEIKKEL 567

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   996 KEKNDLRIKKEQElnqkIKELKEKALSdgQISENERKEIEKLENQRRditVKELS-KTEKEQERI-LVRMQRNRNAYsID 1073
Cdd:TIGR01612  568 EEENEDSIHLEKE----IKDLFDKYLE--IDDEIIYINKLKLELKEK---IKNISdKNEYIKKAIdLKKIIENNNAY-ID 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1074 EASKA--------IKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDkllaIADQRHKDEVRKAKSKKDAVVDvvK 1145
Cdd:TIGR01612  638 ELAKIspyqvpehLKNKDKIYSTIKSELSKIYEDDIDALYNELSSIVKENA----IDNTEDKAKLDDLKSKIDKEYD--K 711

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158  1146 KQNKDIDK-EMDLSSGRVYKN--------TEKWWNG-----LKSWWSNFREDQKKKSDK---YAKEQEE 1197
Cdd:TIGR01612  712 IQNMETATvELHLSNIENKKNelldiiveIKKHIHGeinkdLNKILEDFKNKEKELSNKindYAKEKDE 780
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 917-1392 7.15e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.12  E-value: 7.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   917 KYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKrNKKELEKTQELIDKY--------SAFDEQEK 988
Cdd:TIGR01612 1457 KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADK-NAKAIEKNKELFEQYkkdvtellNKYSALAI 1535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   989 QNILTRTKEKNDLRIKKeqelnqkIKELKEKALSDGQISENERKEI----------------------------EKLENQ 1040
Cdd:TIGR01612 1536 KNKFAKTKKDSEIIIKE-------IKDAHKKFILEAEKSEQKIKEIkkekfrieddaakndksnkaaidiqlslENFENK 1608

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1041 RRDIT---------VKELSKTEKEQERILVRMQRNR------NAYSIDEASKAIKEAEKARKARKKEVD------KQYED 1099
Cdd:TIGR01612 1609 FLKISdikkkindcLKETESIEKKISSFSIDSQDTElkengdNLNSLQEFLESLKDQKKNIEDKKKELDeldseiEKIEI 1688

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1100 DVIAIKNNVNLSKSEKDKLLAIADqrhKDEVRKAK-SKKDAVVDVVKKQNKD----IDKEMDLSS-----GRVYKNTEKW 1169
Cdd:TIGR01612 1689 DVDQHKKNYEIGIIEKIKEIAIAN---KEEIESIKeLIEPTIENLISSFNTNdlegIDPNEKLEEynteiGDIYEEFIEL 1765

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1170 WNGLkswwSNFREDQKKKSDKYakEQEETARRNREN-------IKKWFGNAWDGVKSKtgeafsKMGRNANHFggemkkm 1242
Cdd:TIGR01612 1766 YNII----AGCLETVSKEPITY--DEIKNTRINAQNeflkiieIEKKSKSYLDDIEAK------EFDRIINHF------- 1826

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1243 wsgikgiPSKLSSGWSSAKSSVGYHTKAIANstgkwFGKAWQSVKSTTG-----SIYNQTKQKYSDASDKAWAHSKSiwr 1317
Cdd:TIGR01612 1827 -------KKKLDHVNDKFTKEYSKINEGFDD-----ISKSIENVKNSTDenllfDILNKTKDAYAGIIGKKYYSYKD--- 1891

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1318 GTSKWFSNAYKSAKGWLTDMANKSRAK-WDNISSTAWSNAKSVWKGTSKWFSNSYKSlkdwtGDMYSRAHDRFDAI 1392
Cdd:TIGR01612 1892 EAEKIFINISKLANSINIQIQNNSGIDlFDNINIAILSSLDSEKEDTLKFIPSPEKE-----PEIYTKIRDSYDTL 1962
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 56-200 7.49e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   56 ARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLvEANKKEKLA-LDKSKEALKS--SNTELKKAE 132
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRL-ELEIEEVEArIKKYEEQLGNvrNNKEYEALQ 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  133 NQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQK 200
Cdd:COG1579    96 KEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEA 163
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 27-259 7.59e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 7.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    27 KRQLGVVNSEMKANLSAFDKSEKSMEK----YQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEK--AY 100
Cdd:pfam01576  154 RKLLEERISEFTSNLAEEEEKAKSLSKlknkHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAqiAE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   101 LKLVEANKKEKL--ALDKSKEALKSSNTELKK----------------AENQYK-RTNQRKQDAYQKLKQLR-------- 153
Cdd:pfam01576  234 LRAQLAKKEEELqaALARLEEETAQKNNALKKireleaqiselqedleSERAARnKAEKQRRDLGEELEALKteledtld 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   154 --DAEQKLKNSNQATTAQLKRasdAVQKQSAKHKALVEQYKQEGNQ-VQKLKVQNDNLSKSNDKIEssyaktntKLKQT- 229
Cdd:pfam01576  314 ttAAQQELRSKREQEVTELKK---ALEEETRSHEAQLQEMRQKHTQaLEELTEQLEQAKRNKANLE--------KAKQAl 382

                          250       260       270
                   ....*....|....*....|....*....|
gi 215401158   230 EKEFNDLNNTIKnhSANVAKAETAVNKEKA 259
Cdd:pfam01576  383 ESENAELQAELR--TLQQAKQDSEHKRKKL 410
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 20-281 7.65e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 7.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    20 QEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVE---DELKQVNANYQKAKSSVKDv 96
Cdd:pfam01576  804 QAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQqerDELADEIASGASGKSALQD- 882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    97 EKAYL-----KLVEANKKEKLALDKSKEALKSSNTELKKAENQY---KRTNQRKQDAYQKL-KQLRDAEQKLKNSNQATT 167
Cdd:pfam01576  883 EKRRLeariaQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELaaeRSTSQKSESARQQLeRQNKELKAKLQEMEGTVK 962

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   168 AQLKRASDAVQkqsAKHKALVEQYKQEGNQVQ-----------KLK---VQNDNLSKSNDKIESSYAKTNTKLKQTEKEF 233
Cdd:pfam01576  963 SKFKSSIAALE---AKIAQLEEQLEQESRERQaanklvrrtekKLKevlLQVEDERRHADQYKDQAEKGNSRMKQLKRQL 1039

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 215401158   234 NDlnntiknhsanvakAETAVNKEKAALNNLERSIDKASSEMKTFNKE 281
Cdd:pfam01576 1040 EE--------------AEEEASRANAARRKLQRELDDATESNESMNRE 1073
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 910-1106 8.38e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 8.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   910 ETEKALEKYVHYSEENSRIMEKV--RLNSGQISEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQE 987
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKeKNDLRIKKeQELNQKIKELKEKALSDGQISEnerKEIEKLENQRrditVKELSKTEKEQERIlvRMQRNR 1067
Cdd:TIGR02168  915 RELEELREK-LAQLELRL-EGLEVRIDNLQERLSEEYSLTL---EEAEALENKI----EDDEEEARRRLKRL--ENKIKE 983

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 215401158  1068 ----NAYSIDEAskaikeaeKARKARKKEVDKQYEDDVIAIKN 1106
Cdd:TIGR02168  984 lgpvNLAAIEEY--------EELKERYDFLTAQKEDLTEAKET 1018
PRK00106 PRK00106
ribonuclease Y;
940-1095 8.94e-05

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 47.56  E-value: 8.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  940 SEDKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKEQELNQKIKEL--K 1017
Cdd:PRK00106   51 AERDAEHIKKTAKRESKALKKELLLEAKEEARKYREEIEQEFKSERQELKQIESRLTERATSLDRKDENLSSKEKTLesK 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158 1018 EKALSDGQISENER-KEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIdeASKaIKEAEKARKARKKEVDK 1095
Cdd:PRK00106  131 EQSLTDKSKHIDEReEQVEKLEEQKKAELERVAALSQAEAREIILAETENKLTHEI--ATR-IREAEREVKDRSDKMAK 206
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 9-357 9.88e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.53  E-value: 9.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     9 TLELKLDHLGVqegmkglkrqlGVVNSEMKanlsafdkSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQ----VNA 84
Cdd:pfam12128  255 SAELRLSHLHF-----------GYKSDETL--------IASRQEERQETSAELNQLLRTLDDQWKEKRDELNGelsaADA 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    85 NYQKAKSSVKDVEKAYLKLVEANKkEKLALDKSKEALKSSNTELKKAENQYKRTNQRK-QDAYQKLKQLRDAE------- 156
Cdd:pfam12128  316 AVAKDRSELEALEDQHGAFLDADI-ETAAADQEQLPSWQSELENLEERLKALTGKHQDvTAKYNRRRSKIKEQnnrdiag 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   157 --QKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLkvqndnlsksndkIESSYAKTNTKLKQTekefn 234
Cdd:pfam12128  395 ikDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYR-------------LKSRLGELKLRLNQA----- 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   235 dlnntiknhsanVAKAETAVNKEkaalNNLERsIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIGDKM---- 310
Cdd:pfam12128  457 ------------TATPELLLQLE----NFDER-IERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLeerq 519

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 215401158   311 TSLGRTMTMGVSTPITLgLGAALKTSADFEGQMSRVGAIAQASSKDL 357
Cdd:pfam12128  520 SALDELELQLFPQAGTL-LHFLRKEAPDWEQSIGKVISPELLHRTDL 565
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 909-1092 1.02e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.84  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   909 KETEKALEKyvhysEENSRIMEKVRLNSGQISEDKAKKL-LKIETDLSNNLIAEIEKRNKKELEKTQELIDKYsAFDEQE 987
Cdd:pfam13868  143 KELEKEEER-----EEDERILEYLKEKAEREEEREAEREeIEEEKEREIARLRAQQEKAQDEKAERDELRAKL-YQEEQE 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNiltrtkekndlRIKKEQELNQKIKELKE--KALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQR 1065
Cdd:pfam13868  217 RKE-----------RQKEREEAEKKARQRQElqQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRR 285

                          170       180
                   ....*....|....*....|....*..
gi 215401158  1066 NRNAYSIDEASKAIKEAEKARKARKKE 1092
Cdd:pfam13868  286 MKRLEHRRELEKQIEEREEQRAAEREE 312
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
774-1155 1.12e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  774 GGARFAGVALRFLTGPIGATITAItiaykvfktaydRVEWFRNGINGLGETIKFFGgkIIGGAVRkLGEFKNYLGSIGK- 852
Cdd:COG4913    94 PGDTWSAIAATFANDGSGQTVTLA------------QVFWLKGDASSLGDVKRFFV--IADGPLD-LEDFEEFAHGFDIr 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  853 SFKEKFSKDMKDGYKSLSdddllkvgvnKFKG-FMQTMGTASKKASDTvkvLGKGVS------------------KETEK 913
Cdd:COG4913   159 ALKARLKKQGVEFFDSFS----------AYLArLRRRLGIGSEKALRL---LHKTQSfkpigdlddfvreymleePDTFE 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  914 ALEKYVHYSEENSRI---MEKVRlnsgqiseDKAKKLLKIETDlsnnliAEIEKRNKKELEKTQELIDKYSAFDEQEKQN 990
Cdd:COG4913   226 AADALVEHFDDLERAheaLEDAR--------EQIELLEPIREL------AERYAAARERLAELEYLRAALRLWFAQRRLE 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  991 ILTRTKEKNDLRIkkeQELNQKIKELKEKAlsdgqisENERKEIEKLENQRRDI---TVKELSKTEKEQERILVRMQRNR 1067
Cdd:COG4913   292 LLEAELEELRAEL---ARLEAELERLEARL-------DALREELDELEAQIRGNggdRLEQLEREIERLERELEERERRR 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1068 NAYsiDEASKAIKEAEKARkarkkevdkqyEDDVIAIKNNVNLSKSEKDKLLAIADQ---RHKDEVRKAKSKKDAV---V 1141
Cdd:COG4913   362 ARL--EALLAALGLPLPAS-----------AEEFAALRAEAAALLEALEEELEALEEalaEAEAALRDLRRELRELeaeI 428

                         410
                  ....*....|....
gi 215401158 1142 DVVKKQNKDIDKEM 1155
Cdd:COG4913   429 ASLERRKSNIPARL 442
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 937-1091 1.17e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 44.26  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   937 GQISEDKAKKLLkietdlsnnliaeIEKRNKKELEKTQElidkysafdEQEKQniltrtkEKNDLRIKKEQELNQKIKEL 1016
Cdd:pfam05672    5 GTTDAEEAARIL-------------AEKRRQAREQRERE---------EQERL-------EKEEEERLRKEELRRRAEEE 55

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  1017 KEKALSDGQISENERKEIEklENQRRDITVKELSKTEKEQERiLVRMQRNRnaysiDEA-SKAIKEAEKARKARKK 1091
Cdd:pfam05672   56 RARREEEARRLEEERRREE--EERQRKAEEEAEEREQREQEE-QERLQKQK-----EEAeAKAREEAERQRQEREK 123
46 PHA02562
endonuclease subunit; Provisional
 922-1123 1.21e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  922 SEENSRIMEKVRLNSGQISE-DKAKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKND 1000
Cdd:PHA02562  166 SEMDKLNKDKIRELNQQIQTlDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLN 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1001 LRIKKE------QELNQKIKELK---------EKALSDG--------QISENERKeIEKLENQRRDITVK---------E 1048
Cdd:PHA02562  246 LVMDIEdpsaalNKLNTAAAKIKskieqfqkvIKMYEKGgvcptctqQISEGPDR-ITKIKDKLKELQHSlekldtaidE 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1049 LSKTEKEQERILVRMQRNRNAYS------------IDEASKAIKEAEKARKARKKEVdKQYEDDVIAIKNNVNLSKSEKD 1116
Cdd:PHA02562  325 LEEIMDEFNEQSKKLLELKNKIStnkqslitlvdkAKKVKAAIEELQAEFVDNAEEL-AKLQDELDKIVKTKSELVKEKY 403


                  ....*..
gi 215401158 1117 KLLAIAD 1123
Cdd:PHA02562  404 HRGIVTD 410
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 29-328 1.32e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 47.35  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    29 QLGVVNSEMKANLSAFDKSEKSMEK-YQA--RIKGLNDRLKVQKKMYSQVED------ELKQV-NANYQKAKSSvKDVEK 98
Cdd:TIGR01612  884 KLNDYEKKFNDSKSLINEINKSIEEeYQNinTLKKVDEYIKICENTKESIEKfhnkqnILKEIlNKNIDTIKES-NLIEK 962

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    99 AYLKLVE---ANKK---EKLALDKSKEALKSSNTELKKAENQYK------RTNQRKQDAYQKLKQLRDAEQKLKNSNQ-- 164
Cdd:TIGR01612  963 SYKDKFDntlIDKInelDKAFKDASLNDYEAKNNELIKYFNDLKanlgknKENMLYHQFDEKEKATNDIEQKIEDANKni 1042

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   165 -----ATTAQLKRASDAVQKQSAKHKALVEQykqegNQVQKLKVQNDNLSKSNDKIE----SSYAKTNTkLKQTEkEFND 235
Cdd:TIGR01612 1043 pnieiAIHTSIYNIIDEIEKEIGKNIELLNK-----EILEEAEINITNFNEIKEKLKhynfDDFGKEEN-IKYAD-EINK 1115

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   236 LNNTIKNHSANV-----------AKAETAVNKEKAALNNLERSIDKASS--EMKTFNKEQMIAQSHFGKLASQADVMSKK 302
Cdd:TIGR01612 1116 IKDDIKNLDQKIdhhikaleeikKKSENYIDEIKAQINDLEDVADKAISndDPEEIEKKIENIVTKIDKKKNIYDEIKKL 1195

                          330       340
                   ....*....|....*....|....*....
gi 215401158   303 FSSIGD---KMTSLGRTMTMGVSTPITLG 328
Cdd:TIGR01612 1196 LNEIAEiekDKTSLEEVKGINLSYGKNLG 1224
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 90-243 1.68e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 45.13  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   90 KSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKN-SNQATTA 168
Cdd:cd00176    53 EERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEkEAALASE 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215401158  169 QLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNdkIESSYAKTNTKLKQTEKEFNDLNNTIKNH 243
Cdd:cd00176   133 DLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAEELLEEG--HPDADEEIEEKLEELNERWEELLELAEER 205
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 1803-1915 1.71e-04

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 45.37  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1803 AKDPEKWLKSLKGSGVRSGSGVNKAASAWAGDIRRAAKRMGVnvtsgDVGNIISLIQHESGGNAGITqSSAlrdinvlqg 1882
Cdd:COG0741    75 ALAAFAAIAALAAELLALAALLLRRPLPYLPLIEEAAKKYGV-----DPALVLALIRQESAFNPNAV-SPA--------- 139

                          90       100       110
                  ....*....|....*....|....*....|...
gi 215401158 1883 nPAKGLLQYIPQTFRHYAVRGhnNIYSGYDQLL 1915
Cdd:COG0741   140 -GARGLMQLMPATARRLGLKL--GLGPSPDDLF 169
CAF-1_p150 pfam11600
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...
 955-1095 1.71e-04

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.


Pssm-ID: 402959 [Multi-domain]  Cd Length: 164  Bit Score: 44.29  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   955 SNNLIAEIEKRNKKELEKTQELIDKYSAFD--EQEKQNILTRTKE-----KNDLRIKKEQELNQKIKELKEKalsdgqis 1027
Cdd:pfam11600    3 SQKSVQSQEEKEKQRLEKDKERLRRQLKLEaeKEEKERLKEEAKAekeraKEEARRKKEEEKELKEKERREK-------- 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  1028 eNERKEIEKLENQRrditVKELSKTEKeQERILVRMQRNRNaysiDEASKAIKEAEKARKARKKEVDK 1095
Cdd:pfam11600   75 -KEKDEKEKAEKLR----LKEEKRKEK-QEALEAKLEEKRK----KEEEKRLKEEEKRIKAEKAEITR 132
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
942-1132 1.73e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 45.67  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  942 DKAKKLLKiETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNI---------------LTRTKEKNDLRIKKE 1006
Cdd:COG1340    57 EEAQELRE-KRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNkaggsidklrkeierLEWRQQTEVLSPEEE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1007 QELNQKIKELKEKA-LSDGQISENE-----RKEIEKLENQRRDITvKELSKTEKEQERILVRMQRNRNAY-----SIDEA 1075
Cdd:COG1340   136 KELVEKIKELEKELeKAKKALEKNEklkelRAELKELRKEAEEIH-KKIKELAEEAQELHEEMIELYKEAdelrkEADEL 214

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158 1076 SKAIKEAEKARKARKKEVDKQYEDdviaIKNNVNLSKSEKDKLLAIADQRHKDEVRK 1132
Cdd:COG1340   215 HKEIVEAQEKADELHEEIIELQKE----LRELRKELKKLRKKQRALKREKEKEELEE 267
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 938-1155 1.81e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.07  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   938 QISEDKAKKLLKIETDLSNNLIAEI--------------------------------EKRNKKELEKTQELIDK------ 979
Cdd:pfam13868   27 QIAEKKRIKAEEKEEERRLDEMMEEereraleeeeekeeerkeerkryrqeleeqieEREQKRQEEYEEKLQEReqmdei 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   980 ---YSAFDEQEKQNILTRTKEK-------NDLRIK-------KEQELNQKIKE-LKEKALSDGQIsENERKEIEKLENQR 1041
Cdd:pfam13868  107 verIQEEDQAEAEEKLEKQRQLreeidefNEEQAEwkelekeEEREEDERILEyLKEKAEREEER-EAEREEIEEEKERE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1042 RDITVKELSKTEKEQERI-LVRMQRNRNAYSIDEASKAIKEAEKaRKARKKEVDKQYEDDVIaiknnvnlsksEKDKLLA 1120
Cdd:pfam13868  186 IARLRAQQEKAQDEKAERdELRAKLYQEEQERKERQKEREEAEK-KARQRQELQQAREEQIE-----------LKERRLA 253

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 215401158  1121 IADQRHKDEVRKakskkdavvdVVKKQNKDIDKEM 1155
Cdd:pfam13868  254 EEAEREEEEFER----------MLRKQAEDEEIEQ 278
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 996-1209 1.99e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 45.68  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   996 KEKNDLRIKKEQELNQKIKELKEKALsdgqiseNERKEIEKLENQRRDITVKELSK--TEKEQERILVRMQRNRNAYSID 1073
Cdd:pfam13868   32 KRIKAEEKEEERRLDEMMEEERERAL-------EEEEEKEEERKEERKRYRQELEEqiEEREQKRQEEYEEKLQEREQMD 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1074 EASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRhkdeVRKAKSKKDAVVDVVKKQNKDIDK 1153
Cdd:pfam13868  105 EIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDER----ILEYLKEKAEREEEREAEREEIEE 180

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  1154 EMDLSSGRVYKNTEKwwnglkswwsnfREDQKKKSDK--YAKEQEETARRNRENIKKW 1209
Cdd:pfam13868  181 EKEREIARLRAQQEK------------AQDEKAERDElrAKLYQEEQERKERQKEREE 226
PRK01156 PRK01156
chromosome segregation protein; Provisional
 48-315 2.27e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.43  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   48 EKSMEKYQARIKGLNDRLKVQKKMYSQVE-DELKQVNANYQKAKSSVKDVEKAYLKLVE-ANKKEKLALDKSK------E 119
Cdd:PRK01156  482 EEKIREIEIEVKDIDEKIVDLKKRKEYLEsEEINKSINEYNKIESARADLEDIKIKINElKDKHDKYEEIKNRykslklE 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  120 ALKSSNTELKKAENQYK----RTNQRKQDayQKLKQLRDAEQKLK-------NSNQATTAQLKRASDAVQ------KQSA 182
Cdd:PRK01156  562 DLDSKRTSWLNALAVISlidiETNRSRSN--EIKKQLNDLESRLQeieigfpDDKSYIDKSIREIENEANnlnnkyNEIQ 639

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  183 KHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALN 262
Cdd:PRK01156  640 ENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRIN 719

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 215401158  263 NLERSIDKASSEMKTFNKEQMIAQShFGKLASQAdvMSKKfsSIGDKMTSLGR 315
Cdd:PRK01156  720 DINETLESMKKIKKAIGDLKRLREA-FDKSGVPA--MIRK--SASQAMTSLTR 767
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
45-266 2.34e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.21  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   45 DKSEKSMEKYQARIKGLNDRLKVQKKMYS---QVEDELKQVNANYQKAKSSVKDVEKAYLKL---VEANKKEKLALDKSK 118
Cdd:PRK03918  158 DDYENAYKNLGEVIKEIKRRIERLEKFIKrteNIEELIKEKEKELEEVLREINEISSELPELreeLEKLEKEVKELEELK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  119 EALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKnSNQATTAQLKRasdaVQKQSAKHKALVEQYKQEGNQV 198
Cdd:PRK03918  238 EEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELE-EKVKELKELKE----KAEEYIKLSEFYEEYLDELREI 312

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  199 QKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLnntiKNHSANVAKAETAVNKEKAALNNLER 266
Cdd:PRK03918  313 EKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL----EKRLEELEERHELYEEAKAKKEELER 376
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 942-1051 2.73e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 45.39  E-value: 2.73e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    942 DKAKKLLKIETDLSNNLIAEIEKRnKKELEKTQELIDKYSAFDEQEKQNILTRTKEK-------NDLRIKKEQELNQKIK 1014
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDR-KDALEEELRQLKQLEDELEDCDPTELDRAKEKlkkllqeIMIKVKKLEELEEELQ 235

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|.
gi 215401158   1015 ELKEKaLSDG--QISE--NERKEIEKLENQRRDITVKELSK 1051
Cdd:smart00787  236 ELESK-IEDLtnKKSElnTEIAEAEKKLEQCRGFTFKEIEK 275
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
71-257 2.77e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   71 MYSQVEDELKQVNA---------NYQKAKSSVKDVE--KAYLKLVEANKKEKL---ALDKSKEALKSSNTELKKAENQYK 136
Cdd:COG4913   240 AHEALEDAREQIELlepirelaeRYAAARERLAELEylRAALRLWFAQRRLELleaELEELRAELARLEAELERLEARLD 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  137 RTNQRKQDAYQKL------------KQLRDAEQKLKN--------SNQATTAQLKRASDA--VQKQSAKHKALVEQYKQE 194
Cdd:COG4913   320 ALREELDELEAQIrgnggdrleqleREIERLERELEErerrrarlEALLAALGLPLPASAeeFAALRAEAAALLEALEEE 399

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  195 GNQVQKLKvqndnlsksnDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKE 257
Cdd:COG4913   400 LEALEEAL----------AEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEA 452
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 52-236 2.78e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 45.39  E-value: 2.78e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     52 EKYQARIKGLNDRLKVQKKMYSQVEdelKQVNAN-------YQKAKSSVKDVEKAYLKLVEAN-----KKE--------- 110
Cdd:smart00787   66 ELYQFSCKELKKYISEGRDLFKEIE---EETLINnpplfkeYFSASPDVKLLMDKQFQLVKTFarleaKKMwyewrmkll 142

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    111 ---KLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKL-KQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKA 186
Cdd:smart00787  143 eglKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMI 222

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....
gi 215401158    187 LVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQ----TEKEFNDL 236
Cdd:smart00787  223 KVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQcrgfTFKEIEKL 276
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 126-276 2.90e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  126 TELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKqsakHKALVEQYKQEGNQVQKLKVQN 205
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEE----VEARIKKYEEQLGNVRNNKEYE 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158  206 DnLSKsndKIESsyakTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMK 276
Cdd:COG1579    93 A-LQK---EIES----LKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE 155
F-BAR_PSTPIP1 cd07671
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
 78-243 2.91e-04

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Proline-Serine-Threonine Phosphatase-Interacting Protein 1 (PSTPIP1), also known as CD2 Binding Protein 1 (CD2BP1), is mainly expressed in hematopoietic cells. It is a binding partner of the cell surface receptor CD2 and PTP-PEST, a tyrosine phosphatase which functions in cell motility and Rac1 regulation. It also plays a role in the activation of the Wiskott-Aldrich syndrome protein (WASP), which couples actin rearrangement and T cell activation. Mutations in the gene encoding PSTPIP1 cause the autoinflammatory disorder known as PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. PSTPIP1 contains an N-terminal F-BAR domain, PEST motifs, and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153355 [Multi-domain]  Cd Length: 242  Bit Score: 44.57  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   78 ELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNtelKKAENQYKRTNQRKQDAYQK-LKQLRDAE 156
Cdd:cd07671    54 EINTLKASFDQLKQQIENIGNSHIQLAGMLREELKSLEEFRERQKEQR---KKYEAVMERVQKSKVSLYKKtMESKKTYE 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  157 QKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQN-DNLSKSNDKIESSYAKTNTKLKQTEKE-FN 234
Cdd:cd07671   131 QRCREADEAEQTFERSSSTGNPKQSEKSQNKAKQCRDAATEAERVYKQNiEQLDKARTEWETEHILTCEVFQLQEDDrIT 210


                  ....*....
gi 215401158  235 DLNNTIKNH 243
Cdd:cd07671   211 ILRNALWVH 219
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 941-1153 2.95e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.19  E-value: 2.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   941 EDKAKKLLKIETDLSNNLIAEIEKRNKKELEKtQELIDKYSAFDEQEKQNILTRT-------KEKNDLRIKKEQELNQKI 1013
Cdd:TIGR00606  905 KDAKEQDSPLETFLEKDQQEKEELISSKETSN-KKAQDKVNDIKEKVKNIHGYMKdienkiqDGKDDYLKQKETELNTVN 983

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1014 KELKEkalsdgqiSENERKEIEK-LENQRRDItvkelsKTEKEQERI----LVRMQRNRNAYSIDEASKA-IKEAEKARK 1087
Cdd:TIGR00606  984 AQLEE--------CEKHQEKINEdMRLMRQDI------DTQKIQERWlqdnLTLRKRENELKEVEEELKQhLKEMGQMQV 1049

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215401158  1088 ARKKEVDKQYEDDVIAIKNNVNLSKS-----EKDKLLAIADQRHKdEVRKAKSK-KDAVVD--VVKKQNKDIDK 1153
Cdd:TIGR00606 1050 LQMKQEHQKLEENIDLIKRNHVLALGrqkgyEKEIKHFKKELREP-QFRDAEEKyREMMIVmrTTELVNKDLDI 1122
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 19-197 3.08e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKkmysqveDELKQVNANYQKAKSSVKDVE- 97
Cdd:COG3883    35 AQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERR-------EELGERARALYRSGGSVSYLDv 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   98 --------------KAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSN 163
Cdd:COG3883   108 llgsesfsdfldrlSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL 187

                         170       180       190
                  ....*....|....*....|....*....|....
gi 215401158  164 QATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQ 197
Cdd:COG3883   188 SAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 908-1167 3.37e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.78  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   908 SKETE-KALEKYVHYSEENSRIMEKvRLNSGQISEDKAKKLLKIETDLSNNLiaeieKRNKKELE-KTQELIDKYSAFde 985
Cdd:TIGR04523  451 VKELIiKNLDNTRESLETQLKVLSR-SINKIKQNLEQKQKELKSKEKELKKL-----NEEKKELEeKVKDLTKKISSL-- 522

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   986 QEKQNILtrTKEKNdlrikkeqELNQKIKELKEKALSDGQISENERKEIEKLENQrrditvKELSKTEKEQERILVrmqr 1065
Cdd:TIGR04523  523 KEKIEKL--ESEKK--------EKESKISDLEDELNKDDFELKKENLEKEIDEKN------KEIEELKQTQKSLKK---- 582

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1066 nrnaySIDEASKAIKEAEKARKARKKEVDKqYEDDVIAIKNNVNLSKSEKDKLLAIadqrhkdeVRKAKSKKDAVVDVVK 1145
Cdd:TIGR04523  583 -----KQEEKQELIDQKEKEKKDLIKEIEE-KEKKISSLEKELEKAKKENEKLSSI--------IKNIKSKKNKLKQEVK 648

                          250       260
                   ....*....|....*....|..
gi 215401158  1146 KQNKDIDKEMDLSSGRVYKNTE 1167
Cdd:TIGR04523  649 QIKETIKEIRNKWPEIIKKIKE 670
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
941-1118 3.52e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDLSNNLIAEIEK--RNKKELEKT----QELIDKYSAFDEQ--EKQNILTRTKEKNDL--RIKKEQELN 1010
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKEleEELKEAEEKeeeyAELQEELEELEEEleELEAELEELREELEKleKLLQLLPLY 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1011 QKIKELKEKALSDGQISENERKEIEKLENQRRDItvKELSKTEKEQERILVRMQRNRNAYSIDEASKAIKEAEKARKARk 1090
Cdd:COG4717   132 QELEALEAELAELPERLEELEERLEELRELEEEL--EELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRL- 208

                         170       180
                  ....*....|....*....|....*...
gi 215401158 1091 kevdKQYEDDVIAIKNNVNLSKSEKDKL 1118
Cdd:COG4717   209 ----AELEEELEEAQEELEELEEELEQL 232
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 957-1204 3.61e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 3.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   957 NLIAEIEKRNKKELEKTQELIDKYSAFDEqekqniltRTKEKNDLRiKKEQELNQKIKELKEKAlsdgqisENERKEIEK 1036
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEE--------LEEELEQLR-KELEELSRQISALRKDL-------ARLEAEVEQ 744

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1037 LENQRRDItvkELSKTEKEQERILVRMQRNrnaysidEASKAIKEAEKARKARKKEVDKQyeddviaiKNNVNLSKSEKD 1116
Cdd:TIGR02168  745 LEERIAQL---SKELTELEAEIEELEERLE-------EAEEELAEAEAEIEELEAQIEQL--------KEELKALREALD 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1117 KLLAIAdQRHKDEVRKAKSKKDAV---VDVVKKQNKDIDKEMDLSSGRVYKNTEKwWNGLKSWWSNFREDQKKKSDKYAK 1193
Cdd:TIGR02168  807 ELRAEL-TLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAE-IEELEELIEELESELEALLNERAS 884

                          250
                   ....*....|.
gi 215401158  1194 EQEETARRNRE 1204
Cdd:TIGR02168  885 LEEALALLRSE 895
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 954-1098 3.81e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  954 LSNNLIAEIEKRNKKELEKTQELIDKYSafdEQEKQniltrTKEKNDLRIKKEQELNQKIKELKEKALsdgQISENERKE 1033
Cdd:PRK00409  499 LPENIIEEAKKLIGEDKEKLNELIASLE---ELERE-----LEQKAEEAEALLKEAEKLKEELEEKKE---KLQEEEDKL 567

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158 1034 IEKLENQRRDItVKELSKTEKEQERILVRMQR----NRNAYSIDEASKAIKEAEKARKARKKEVDKQYE 1098
Cdd:PRK00409  568 LEEAEKEAQQA-IKEAKKEADEIIKELRQLQKggyaSVKAHELIEARKRLNKANEKKEKKKKKQKEKQE 635
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 953-1154 3.85e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   953 DLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQ-NILTRTKEKNDLRIK--------KEQELNQKIKELK--EKAL 1021
Cdd:TIGR02169  688 RELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEiEQLEQEEEKLKERLEeleedlssLEQEIENVKSELKelEARI 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1022 SDGQIS-ENERKEIEKLE----NQRRDITVKELSKTEKEQERILVRMQR-----NRNAYSIDEASKAIKEAEKAR---KA 1088
Cdd:TIGR02169  768 EELEEDlHKLEEALNDLEarlsHSRIPEIQAELSKLEEEVSRIEARLREieqklNRLTLEKEYLEKEIQELQEQRidlKE 847

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158  1089 RKKEVDKQYEDDVIAIKnnvNLSKSEKDKLLAIAD--QRHKD---EVRKAKSKKDAVVDVVKKQNKDIDKE 1154
Cdd:TIGR02169  848 QIKSIEKEIENLNGKKE---ELEEELEELEAALRDleSRLGDlkkERDELEAQLRELERKIEELEAQIEKK 915
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
24-276 4.65e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.52  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   24 KGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLkvqkkmysqveDELKQVNANYQKAKSSVKDVEKAYLKL 103
Cdd:COG1340    53 KELREEAQELREKRDELNEKVKELKEERDELNEKLNELREEL-----------DELRKELAELNKAGGSIDKLRKEIERL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  104 VEANKKEKLALDKSKEALKssntELKKAENQYKrtnqrkqdayqKLKQLRDAEQKLKNsnqaTTAQLKRASDAVQKQSAK 183
Cdd:COG1340   122 EWRQQTEVLSPEEEKELVE----KIKELEKELE-----------KAKKALEKNEKLKE----LRAELKELRKEAEEIHKK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  184 HKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKnhsanvaKAETAVNKEKAALNN 263
Cdd:COG1340   183 IKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELR-------ELRKELKKLRKKQRA 255

                         250
                  ....*....|...
gi 215401158  264 LERSIDKASSEMK 276
Cdd:COG1340   256 LKREKEKEELEEK 268
PTZ00121 PTZ00121
MAEBL; Provisional
 36-297 4.81e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   36 EMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKlALD 115
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELK 1708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  116 KSKEALKSSNTELKKAENQYK-RTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQE 194
Cdd:PTZ00121 1709 KKEAEEKKKAEELKKAEEENKiKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEE 1788

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  195 GNQVQKLKVQNDNLSKSNDKIESSYAKTNT----KLKQTE----KEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLEr 266
Cdd:PTZ00121 1789 DEKRRMEVDKKIKDIFDNFANIIEGGKEGNlvinDSKEMEdsaiKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKE- 1867

                         250       260       270
                  ....*....|....*....|....*....|.
gi 215401158  267 sidkASSEMKTFNKEQMIAQSHFGKLASQAD 297
Cdd:PTZ00121 1868 ----ADFNKEKDLKEDDEEEIEEADEIEKID 1894
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 908-1156 5.15e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 5.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   908 SKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKAKKLLKIETDLSNNLIaeiekrnKKELEKTQELIDKYsafdEQE 987
Cdd:TIGR04523  508 LEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENL-------EKEIDEKNKEIEEL----KQT 576

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   988 KQNILTRTKEKNDLRIKKEQELNQKIKELKEKAlsdgqisenerKEIEKLEnqrrditvKELSKTEKEQERILVRMQRNR 1067
Cdd:TIGR04523  577 QKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKE-----------KKISSLE--------KELEKAKKENEKLSSIIKNIK 637

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1068 NAY-SIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLA-----IADQRHKDEVRKAKSKKDAVV 1141
Cdd:TIGR04523  638 SKKnKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLhykkyITRMIRIKDLPKLEEKYKEIE 717

                          250
                   ....*....|....*
gi 215401158  1142 DVVKKQnKDIDKEMD 1156
Cdd:TIGR04523  718 KELKKL-DEFSKELE 731
F-BAR_PSTPIP cd07647
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
 64-193 5.42e-04

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Proteins; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Vetebrates contain two Proline-Serine-Threonine Phosphatase-Interacting Proteins (PSTPIPs), PSTPIP1 and PSTPIP2. PSTPIPs are mainly expressed in hematopoietic cells and are involved in the regulation of cell adhesion and motility. Mutations in PSTPIPs have been shown to cause autoinflammatory disorders. PSTPIP1 contains an N-terminal F-BAR domain, PEST motifs, and a C-terminal SH3 domain, while PSTPIP2 contains only the N-terminal F-BAR domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153331 [Multi-domain]  Cd Length: 239  Bit Score: 43.62  E-value: 5.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   64 RLKVQKKMYSQVEDELKQ---VNANYQKA-----------------KSS-------VKDVEKAYLKLVEANKKEklaLDK 116
Cdd:cd07647    13 RLKEGKKMCKELEDFLKQrakAEEDYGKAllklsksagpgdeigtlKSSwdslrkeTENVANAHIQLAQSLREE---AEK 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  117 SKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDA-EQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQ 193
Cdd:cd07647    90 LEEFREKQKEERKKTEDIMKRSQKNKKELYKKTMKAKKSyEQKCREKDKAEQAYEKSSSGAQPKEAEKLKKKAAQCKT 167
YkyA pfam10368
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ...
 36-236 5.45e-04

Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity.


Pssm-ID: 431235 [Multi-domain]  Cd Length: 185  Bit Score: 42.96  E-value: 5.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    36 EMKANLSAFDKSEKSMEKYQariKGLNDRLKVQKKMYSQV----EDELKQVNANYQKAKSSVKDVEKAYlklveanKKEK 111
Cdd:pfam10368    5 KIYDHLEEAVELEKPFEEQQ---EPLVELEKKEQELYEEIielgMDEFDEIKKLSDEALENVEEREELL-------EKEK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   112 LALDKSKEALKSSNTELKKAENqykrtnqrkqdayqklKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQY 191
Cdd:pfam10368   75 ESIEEAKEEFKKIKEIIEEIED----------------EELKKEAEELIDAMEERYEAYDELYDAYKKALELDKELYEML 138

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 215401158   192 KQEGNQVQKLKVQNDNLSKSNDKIEssyaKTNTKLKQTEKEFNDL 236
Cdd:pfam10368  139 KDEDLTLEELQEQIEKINESYEEVK----EANEQFNEYTKQYNEL 179
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 3-270 5.82e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 44.83  E-value: 5.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    3 EKVEGMTLELKLDHlgVQEGMKGLKRQL----GVVNSEMKAnlsafdksEKSMEKYQARIKglnDRLKVQKKMYSQVEDE 78
Cdd:PRK04778  266 DENLALLEELDLDE--AEEKNEEIQERIdqlyDILEREVKA--------RKYVEKNSDTLP---DFLEHAKEQNKELKEE 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   79 LKQVNANY----------QKAKSSVKDVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQ-----RK- 142
Cdd:PRK04778  333 IDRVKQSYtlneselesvRQLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEKEQEKLSEmlqglRKd 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  143 -QDAYQKL----KQLRDAEQKLKNSN------------QATTAQLKRAS----------DAVQKQSAKHKALVEQYKQEG 195
Cdd:PRK04778  413 eLEAREKLeryrNKLHEIKRYLEKSNlpglpedylemfFEVSDEIEALAeeleekpinmEAVNRLLEEATEDVETLEEET 492

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  196 NQVqklkVQNDNLSK-----SNdKIESSYAKTNTKLKQTEKEFNDLnntikNHSANVAKAETAVNK-EKAALNNLERSID 269
Cdd:PRK04778  493 EEL----VENATLTEqliqyAN-RYRSDNEEVAEALNEAERLFREY-----DYKAALEIIATALEKvEPGVTKRIEDSYE 562


                  .
gi 215401158  270 K 270
Cdd:PRK04778  563 K 563
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 985-1156 5.84e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  985 EQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEkalSDGQISENERKeIEKLENQRRDITvKELSKTEKEQERILVRMQ 1064
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAA---LERRIAALARR-IRALEQELAALE-AELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1065 RNRNAY--------------------SIDEASKAIKEAE------KARKARKKEVDKQYEdDVIAIKNNVNLSKSEKDKL 1118
Cdd:COG4942   101 AQKEELaellralyrlgrqpplalllSPEDFLDAVRRLQylkylaPARREQAEELRADLA-ELAALRAELEAERAELEAL 179

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 215401158 1119 LAIADQRhKDEVRKAKSKKDAVVDVVKKQNKDIDKEMD 1156
Cdd:COG4942   180 LAELEEE-RAALEALKAERQKLLARLEKELAELAAELA 216
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 913-1088 6.53e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 6.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  913 KALEKYVHYSEENSRIMEKvRLNSGQISEDKAKKLLKIETDLSNNLIAEIEKRNK-------------KELEKTQELIDK 979
Cdd:COG4942    65 AALARRIRALEQELAALEA-ELAELEKEIAELRAELEAQKEELAELLRALYRLGRqpplalllspedfLDAVRRLQYLKY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  980 YSAFDEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKalsdgqisENERKEIEKLENQRRDiTVKELSKTEKEQERI 1059
Cdd:COG4942   144 LAPARREQAEELRADLAELAALRAELEAERAELEALLAEL--------EEERAALEALKAERQK-LLARLEKELAELAAE 214

                         170       180
                  ....*....|....*....|....*....
gi 215401158 1060 LVRMQRNRNAYSiDEASKAIKEAEKARKA 1088
Cdd:COG4942   215 LAELQQEAEELE-ALIARLEAEAAAAAER 242
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 46-319 7.21e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 7.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    46 KSEKSMEKYQARIKGLNDRLKVQKKMYSQVEdelkQVNANYQKAKSSVKDVE------------KAYLKLVEANKKEKLA 113
Cdd:pfam05557  122 RAELELQSTNSELEELQERLDLLKAKASEAE----QLRQNLEKQQSSLAEAEqrikelefeiqsQEQDSEIVKNSKSELA 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   114 ----LDKSKEALKSSNTELkkaeNQYKRTN----------QRKQDAYQKLK--------QLRDAEQKLK---NSNQATTA 168
Cdd:pfam05557  198 ripeLEKELERLREHNKHL----NENIENKlllkeevedlKRKLEREEKYReeaatlelEKEKLEQELQswvKLAQDTGL 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   169 QLKRASDAVQKqsakhkalVEQYKQEgNQVqkLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANV- 247
Cdd:pfam05557  274 NLRSPEDLSRR--------IEQLQQR-EIV--LKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVr 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   248 --AKAETAVNKEKAALNNLERSIDKASSEMKTFNK--------EQMI--AQSHFGKLASQADVMSKKFSSIGDKMTSLGR 315
Cdd:pfam05557  343 rlQRRVLLLTKERDGYRAILESYDKELTMSNYSPQllerieeaEDMTqkMQAHNEEMEAQLSVAEEELGGYKQQAQTLER 422


                   ....
gi 215401158   316 TMTM 319
Cdd:pfam05557  423 ELQA 426
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 105-287 7.71e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.58  E-value: 7.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   105 EANKKEKLALDKSKEALKSSNTELKKAENQYKRT---NQRKQDAYQKLKQLRDAEQKLKNSNQATtaQLKRASDAVQKQS 181
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLkeqAKKALEYYQLKEKLELEEEYLLYLDYLK--LNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   182 AKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESS----YAKTNTKLKQTEKEF-------NDLNNTIKNHSANVAKA 250
Cdd:pfam02463  247 RDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLqeeeLKLLAKEEEELKSELlklerrkVDDEEKLKESEKEKKKA 326

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 215401158   251 ETAVNKEKAALNNLErsIDKASSEMKTFNKEQMIAQS 287
Cdd:pfam02463  327 EKELKKEKEEIEELE--KELKELEIKREAEEEEEEEL 361
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 58-266 8.04e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.43  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   58 IKGLNDRLKVQKKMYSQVEDELKQVNANYQkakssvkDVEKAYLKLVEANKKEKLALDKS-KEALKssntELKKAENQY- 135
Cdd:PRK00409  522 IASLEELERELEQKAEEAEALLKEAEKLKE-------ELEEKKEKLQEEEDKLLEEAEKEaQQAIK----EAKKEADEIi 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  136 --KRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLK---------RASDAVQKQSAKHKALVEQYKQEGN-QVQ---- 199
Cdd:PRK00409  591 keLRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKkqkekqeelKVGDEVKYLSLGQKGEVLSIPDDKEaIVQagim 670

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158  200 KLKVQNDNLSKSND--KIESSYAKTNTKLKQTEKefndlnNTIKNHSANVAKAETAVNK--EKAALNNLER 266
Cdd:PRK00409  671 KMKVPLSDLEKIQKpkKKKKKKPKTVKPKPRTVS------LELDLRGMRYEEALERLDKylDDALLAGYGE 735
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 917-1208 1.04e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.24  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   917 KYVHYSEENSRIMEKVRLNSGQISEdKAKKLLKIETDLsNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQnILTRTK 996
Cdd:TIGR04523  219 QISELKKQNNQLKDNIEKKQQEINE-KTTEISNTQTQL-NQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQ-LNQLKS 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   997 EKNDLRIKKEQELNQKIKEL-----KEKALSDGQISENERK------EIEKLENQRRDITVKELSK----TEKEQERILV 1061
Cdd:TIGR04523  296 EISDLNNQKEQDWNKELKSElknqeKKLEEIQNQISQNNKIisqlneQISQLKKELTNSESENSEKqrelEEKQNEIEKL 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1062 RMQRNRNAYSIDEASKAIKEAEkaRKARKKEVDKQYEDDVIAIKnnvnlsKSEKDKLlaiaDQRHKDeVRKAKSKKDAVV 1141
Cdd:TIGR04523  376 KKENQSYKQEIKNLESQINDLE--SKIQNQEKLNQQKDEQIKKL------QQEKELL----EKEIER-LKETIIKNNSEI 442

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158  1142 DVVKKQNKDIDKEmdlssgrvYKNTEkwwnglkswwsNFREDQKKKSDKYAKEQEETaRRNRENIKK 1208
Cdd:TIGR04523  443 KDLTNQDSVKELI--------IKNLD-----------NTRESLETQLKVLSRSINKI-KQNLEQKQK 489
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 76-302 1.07e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.40  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    76 EDELKQVNANYQKAKSSVKDVEKAYLKLVE--------------------------ANKKEKLaldksKEALKSSNTELK 129
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEeknalqeqlqaetelcaeaeemrarlAARKQEL-----EEILHELESRLE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   130 KAE-------NQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKR-------ASDAVQKQSAKHKALVEQYKQEG 195
Cdd:pfam01576   86 EEEersqqlqNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKleedillLEDQNSKLSKERKLLEERISEFT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   196 NQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEK--------------EFNDLNNTIKNHSANVAKAETAVNKEKAAL 261
Cdd:pfam01576  166 SNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKgrqelekakrklegESTDLQEQIAELQAQIAELRAQLAKKEEEL 245

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 215401158   262 NNLERSIDKASSEMKTFNKEQMIAQSHFGKLasQADVMSKK 302
Cdd:pfam01576  246 QAALARLEEETAQKNNALKKIRELEAQISEL--QEDLESER 284
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
143-271 1.09e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  143 QDAYQKLKQLRDAEQKLK---NSNQATTAQLKRASDAVQKQSAKHKALVEQYKQE------GNQVQKLKVQNDNLSKSND 213
Cdd:COG4913   606 FDNRAKLAALEAELAELEeelAEAEERLEALEAELDALQERREALQRLAEYSWDEidvasaEREIAELEAELERLDASSD 685

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215401158  214 KI---ESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKA 271
Cdd:COG4913   686 DLaalEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE 746
CENP-F_N pfam10481
Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound ...
 145-267 1.16e-03

Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.


Pssm-ID: 463106 [Multi-domain]  Cd Length: 304  Bit Score: 43.27  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   145 AYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQsaKHKAlveqyKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNT 224
Cdd:pfam10481   16 ALQKIQELESQLDKLKKERQQKQFQLESLEAALQKQ--KQKV-----ENEKNEGSALKRENQSLMESCDNLEKSRQKISH 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 215401158   225 KLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKaalNNLERS 267
Cdd:pfam10481   89 DLQVKESQVNFLEGQLNSSKKQIEKLEQELKRYK---SELERS 128
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 940-1208 1.30e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   940 SEDKAKKLLKIETD------LSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKqNILTRTKEKNDLRIKKEQELNQKI 1013
Cdd:TIGR04523   52 KEKELKNLDKNLNKdeekinNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLS-KINSEIKNDKEQKNKLEVELNKLE 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1014 KELKE-KALSDGQISE--NERKEIEKLENQRRDITV------KELSKTEKEQERILVRMQRNRNAYSIDEASKAIKeaeK 1084
Cdd:TIGR04523  131 KQKKEnKKNIDKFLTEikKKEKELEKLNNKYNDLKKqkeeleNELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNL---K 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1085 ARKARKKEVDKQYED---DVIAIKNNVNLSKSEKDKLLAIAdQRHKDEVRKAKSKKDAVVDVVKKQNKDIDKemdlsSGR 1161
Cdd:TIGR04523  208 KKIQKNKSLESQISElkkQNNQLKDNIEKKQQEINEKTTEI-SNTQTQLNQLKDEQNKIKKQLSEKQKELEQ-----NNK 281

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 215401158  1162 VYKNTEKWWNGLKSWWSNFREDQKKKSDKYAKEQEETARRNRENIKK 1208
Cdd:TIGR04523  282 KIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQN 328
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 68-317 1.32e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.79  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   68 QKKMYSQVEDELKQVNANYQKAKSSVKDVEKAYLKLVEANKK-------------EKLALDKSKEALKSSNTELKKAENQ 134
Cdd:COG5185   223 EKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDlrleklgenaessKRLNENANNLIKQFENTKEKIAEYT 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  135 YKRTNQRKQDAYQKLKQLRDAEQKL-------KNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKvqndN 207
Cdd:COG5185   303 KSIDIKKATESLEEQLAAAEAEQELeeskretETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSE----E 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  208 LSKSNDKIESSYAKTNTKLKQTEKEFND----LNNTIKNHSANVAKAETAVNKE-------KAALNNLERSIDKASSEMK 276
Cdd:COG5185   379 LDSFKDTIESTKESLDEIPQNQRGYAQEilatLEDTLKAADRQIEELQRQIEQAtssneevSKLLNELISELNKVMREAD 458

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 215401158  277 TFNKEQMI--AQSHFGKLASQADVMSKKFSSIGDKMTSLGRTM 317
Cdd:COG5185   459 EESQSRLEeaYDEINRSVRSKKEDLNEELTQIESRVSTLKATL 501
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 113-307 1.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  113 ALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRD----AEQKLKNSNQ---ATTAQLKRASDAVQKQSAKHK 185
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERriaaLARRIRALEQelaALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  186 ALVEQYKQEGNQVQK-------------------------LKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTI 240
Cdd:COG4942   101 AQKEELAELLRALYRlgrqpplalllspedfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELEALL 180

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158  241 KNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIG 307
Cdd:COG4942   181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
secA PRK12903
preprotein translocase subunit SecA; Reviewed
 842-1099 1.33e-03

preprotein translocase subunit SecA; Reviewed


Pssm-ID: 237258 [Multi-domain]  Cd Length: 925  Bit Score: 43.89  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  842 EFKNYlgsIGKSFKEKFSKDMKDGYKSLSDDDLLKVGVNKFKGF-----MQTMGTASKKASDTVKVLGKGVSketekaLE 916
Cdd:PRK12903  671 DFENY---HKEELAQYLIEALNEIYFKKRQVILDKIALNTFFESeryiiLSALDKYWQNHIDTMDKLRSGVN------LV 741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  917 KYVH------YSEENSRIMEKVRLNsgqISEDKAKKLLKIETDLSNNLIAEIEK---RNKKELEKTQELIDKYSAFDEQ- 986
Cdd:PRK12903  742 QYSQknpyqvYTEEGTKKFNILLQE---IAYDVIVSLFNNPNAEKILIITEILSdgiNNSDINDRPQELIDQIIESEEEr 818

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  987 -EKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQR 1065
Cdd:PRK12903  819 lKALRIQREEMLMRPEELELINEEQKNLKQEIKLELSEIQEAEEEIQNINENKNEFVEFKNDPKKLNKLIIAKDVLIKLV 898

                         250       260       270
                  ....*....|....*....|....*....|....
gi 215401158 1066 NRnaySIDEAskaiKEAEKARKARKKEVDKQYED 1099
Cdd:PRK12903  899 IS---SDEIK----QDEKTTKKKKKDLEKTDEEA 925
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 46-280 1.54e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.89  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    46 KSEKSmEKYQARIKGLNDRLK--VQKKMYSQVEDELK------QVNANYQKAKSSVKDVEKAYLKLVEANKKEKLA---- 113
Cdd:TIGR01612  662 KSELS-KIYEDDIDALYNELSsiVKENAIDNTEDKAKlddlksKIDKEYDKIQNMETATVELHLSNIENKKNELLDiive 740

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   114 ------------LDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQS 181
Cdd:TIGR01612  741 ikkhihgeinkdLNKILEDFKNKEKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYI 820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   182 AKHKALVEQYKQEGNQVQKLKvqNDNLSKSNDKI--ESSYAKtntKLKQTEKEFNDLNNTIKNHSAN--VAKAETAVNKE 257
Cdd:TIGR01612  821 KTISIKEDEIFKIINEMKFMK--DDFLNKVDKFInfENNCKE---KIDSEHEQFAELTNKIKAEISDdkLNDYEKKFNDS 895

                          250       260
                   ....*....|....*....|...
gi 215401158   258 KAALNNLERSIDKASSEMKTFNK 280
Cdd:TIGR01612  896 KSLINEINKSIEEEYQNINTLKK 918
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 41-284 1.65e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.89  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    41 LSAFDKSEKSMEKYQA--RIKGLNDRLKVQK-KMYSQVE------DELKQVNANYQKAKSSVKDVEKAYLKLVEAN---K 108
Cdd:TIGR01612 1980 LNIIFENQQLYEKIQAsnELKDTLSDLKYKKeKILNDVKlllhkfDELNKLSCDSQNYDTILELSKQDKIKEKIDNyekE 2059

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   109 KEKLALDKS----KEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKH 184
Cdd:TIGR01612 2060 KEKFGIDFDvkamEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKDNIIQSKKKLKELTEAFNTEIKIIEDKIIEKNDLI 2139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   185 KALVEQYKQ-----EGNQVQKLKVQ----------------------NDNLSKSNDKIESsyAKTNTKLKQTEKEFNDLN 237
Cdd:TIGR01612 2140 DKLIEMRKEcllfsYATLVETLKSKvinhsefitsaakfskdffefiEDISDSLNDDIDA--LQIKYNLNQTKKHMISIL 2217

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 215401158   238 NTIKNHSANVakaetaVNKEKAA---LNNLER--SIDKASSEMKT--FNKEQMI 284
Cdd:TIGR01612 2218 ADATKDHNNL------IEKEKEAtkiINNLTElfTIDFNNADADIlhNNKIQII 2265
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 47-274 1.67e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   47 SEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKaylklveankkeklALDKSKEALKSSNT 126
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQA--------------EIDKLQAEIAEAEA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  127 ELKKAENQYKrtnQRKQDAYQKLKQLRDAEQkLKNSNQATTAqLKRAsDAVQKQSAKHKALVEQYKQegnQVQKLKVQND 206
Cdd:COG3883    80 EIEERREELG---ERARALYRSGGSVSYLDV-LLGSESFSDF-LDRL-SALSKIADADADLLEELKA---DKAELEAKKA 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158  207 NLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSE 274
Cdd:COG3883   151 ELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAA 218
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 97-280 1.75e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.42  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    97 EKAYLKLVEANKKEKLALDKskealkssNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNSNQATtaQLKRASDA 176
Cdd:pfam02463  172 KEALKKLIEETENLAELIID--------LEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLK--LNEERIDL 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   177 VQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESS----YAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAET 252
Cdd:pfam02463  242 LQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLqeeeLKLLAKEEEELKSELLKLERRKVDDEEKLKESEK 321

                          170       180
                   ....*....|....*....|....*...
gi 215401158   253 AVNKEKAALNNLERSIDKASSEMKTFNK 280
Cdd:pfam02463  322 EKKKAEKELKKEKEEIEELEKELKELEI 349
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 910-1163 1.78e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  910 ETEKALEKYVHYSEEN----SRIMEKVRLNSGQISEDKAKKLLKIETDLSNnLIAEIE--KRNKKELEKTQELIDKYSAF 983
Cdd:PRK05771   54 KLSEALDKLRSYLPKLnplrEEKKKVSVKSLEELIKDVEEELEKIEKEIKE-LEEEISelENEIKELEQEIERLEPWGNF 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  984 D-----EQEKQNI------LTRTKEKNDLRIKkEQELNQKIKELKEK----ALSDGQISENERKEIEKLENQRRDITVKE 1048
Cdd:PRK05771  133 DldlslLLGFKYVsvfvgtVPEDKLEELKLES-DVENVEYISTDKGYvyvvVVVLKELSDEVEEELKKLGFERLELEEEG 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1049 LSKTEkeqerilvrmqrnrnaysIDEASKAIKEAEKARKARK---KEVDKQYEDDVIAIKNnvnlsksekdkLLAIADQR 1125
Cdd:PRK05771  212 TPSEL------------------IREIKEELEEIEKERESLLeelKELAKKYLEELLALYE-----------YLEIELER 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 215401158 1126 HKDEVRKAKSKKDAVVD--VVKKQNKDIDKEMD-LSSGRVY 1163
Cdd:PRK05771  263 AEALSKFLKTDKTFAIEgwVPEDRVKKLKELIDkATGGSAY 303
COG5325 COG5325
t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion];
88-288 1.88e-03

t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion];


Pssm-ID: 227635 [Multi-domain]  Cd Length: 283  Bit Score: 42.52  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   88 KAKSSVKDVEKAYLKLVEANKKEKLALDKSKEAL-KSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDaeqklkNSNQAT 166
Cdd:COG5325    49 AVRRSISRLGKVYAKHTEPSFSDKSEKEDEIDELsKKVNQDLQRCEKILKTKYKNLQSSFLQSKLLRD------LNTECM 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  167 TAQlkrasdAVQKQSAKhkalveQYKQEGNQVQKLKVQNDNLSKSNDK-----IESSYAK-TNTKLKQTEKEFNDLNNTI 240
Cdd:COG5325   123 EGQ------RIQQKSAQ------FRKYQVLQAKFLRNKNNDQHPLEEEedeesLSSLGSQqTLQQQGLSNEELEYQQILI 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215401158  241 KNHSANVAKAETAVN-------------KEKAAL-NNLERSIDKASSEMKTFNKEQMIAQSH 288
Cdd:COG5325   191 TERDEEIKNLARGIYelneifrdlgslvGEQGELvDRIDFNIENTSDNLKNANKELEKAPAH 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 114-274 1.90e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   114 LDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRDAEQKLKNsnqattaQLKRASDAVQKQSAKHKALVEQYKQ 193
Cdd:TIGR04523   42 LKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLND-------KLKKNKDKINKLNSDLSKINSEIKN 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   194 EGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASS 273
Cdd:TIGR04523  115 DKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKN 194


                   .
gi 215401158   274 E 274
Cdd:TIGR04523  195 K 195
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 60-271 2.01e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    60 GLNDRLK-VQKKMYSQVEDELK----QVNANYQKAKSSVKDVEKAylkLVEANKKeklaLDKSKEALKSSNTELKKA-EN 133
Cdd:pfam12128  582 GVKLDLKrIDVPEWAASEEELRerldKAEEALQSAREKQAAAEEQ---LVQANGE----LEKASREETFARTALKNArLD 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   134 QYKRTNQRKQDAYQKlkqlrdaeqklknsNQATTAQLKRASDAVQKQSA-------KHKALVEQYKQE-----GNQVQKL 201
Cdd:pfam12128  655 LRRLFDEKQSEKDKK--------------NKALAERKDSANERLNSLEAqlkqldkKHQAWLEEQKEQkrearTEKQAYW 720

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215401158   202 KV----QNDNLSKSNDKIESSYAKTNTKLKQTEKEFndlnntiKNHSANVAKAETAVNKEKAALNNLERSIDKA 271
Cdd:pfam12128  721 QVvegaLDAQLALLKAAIAARRSGAKAELKALETWY-------KRDLASLGVDPDVIAKLKREIRTLERKIERI 787
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 89-309 2.07e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 43.28  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   89 AKSSVKDVEKAYLKLVEANKKEKLAL-DKskealkssntelKKAENQYKRTNQRKQDAYQKL----KQLRDAEQ-KLKNS 162
Cdd:NF012221 1536 ATSESSQQADAVSKHAKQDDAAQNALaDK------------ERAEADRQRLEQEKQQQLAAIsgsqSQLESTDQnALETN 1603

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  163 NQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDN------LSKSNDKIESSYAKTNTKLKQTEKEFNDL 236
Cdd:NF012221 1604 GQAQRDAILEESRAVTKELTTLAQGLDALDSQATYAGESGDQWRNpfagglLDRVQEQLDDAKKISGKQLADAKQRHVDN 1683

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215401158  237 NNTIKNhsaNVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIGDK 309
Cdd:NF012221 1684 QQKVKD---AVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQ 1753
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 985-1139 2.09e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 42.53  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   985 EQEKQNILTRTKEKNDLRIKKEQelnQKIKELKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQ 1064
Cdd:TIGR02794   66 EQERQKKLEQQAEEAEKQRAAEQ---ARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAER 142

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215401158  1065 RnrnaysidEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDA 1139
Cdd:TIGR02794  143 K--------AKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEA 209
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1007-1127 2.29e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1007 QELNQKIKEL---KEKALSDGQISENER-----KEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIDEASKA 1078
Cdd:COG0542   414 DELERRLEQLeieKEALKKEQDEASFERlaelrDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGKIPELEKE 493

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 215401158 1079 IKEAEKARKARKK----EVDKqyED--DVIAIKNNVNLSK---SEKDKLLAIADQRHK 1127
Cdd:COG0542   494 LAELEEELAELAPllreEVTE--EDiaEVVSRWTGIPVGKlleGEREKLLNLEEELHE 549
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 945-1118 2.35e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.31  E-value: 2.35e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    945 KKLLK-IETDLSNNLiaEIEKRNKKELEKTQELI--------DKYSAFdeQEKQNILTrtKEKNDLRIKKEQELNQkike 1015
Cdd:smart00787  139 MKLLEgLKEGLDENL--EGLKEDYKLLMKELELLnsikpklrDRKDAL--EEELRQLK--QLEDELEDCDPTELDR---- 208

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   1016 LKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQErilvrmqrnrnaySIDEASKAIKEAEKARKARKKEVdK 1095
Cdd:smart00787  209 AKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSE-------------LNTEIAEAEKKLEQCRGFTFKEI-E 274

                           170       180
                    ....*....|....*....|....*
gi 215401158   1096 QYEDDVIAIKN--NVNLSKSEKDKL 1118
Cdd:smart00787  275 KLKEQLKLLQSltGWKITKLSGNTL 299
FCH_F-BAR cd07610
The Extended FES-CIP4 Homology (FCH) or F-BAR (FCH and Bin/Amphiphysin/Rvs) domain, a ...
 903-1069 2.39e-03

The Extended FES-CIP4 Homology (FCH) or F-BAR (FCH and Bin/Amphiphysin/Rvs) domain, a dimerization module that binds and bends membranes; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. F-BAR domain containing proteins, also known as Pombe Cdc15 homology (PCH) family proteins, include Fes and Fer tyrosine kinases, PACSINs/Syndapins, FCHO, PSTPIP, CIP4-like proteins and srGAPs. Many members also contain an SH3 domain and play roles in endocytosis. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. These tubules have diameters larger than those observed with N-BARs. The F-BAR domains of some members such as NOSTRIN and Rgd1 are important for the subcellular localization of the protein.


Pssm-ID: 153294 [Multi-domain]  Cd Length: 191  Bit Score: 41.17  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  903 LGKGVSKETEKALEKYVHYSEENSRIMEKVRLNSGQISEDK------AKKLLKIETDLSNNLIAEIEKRnkkeleKTQEL 976
Cdd:cd07610    11 LGLDLLKDLREFLKKRAAIEEEYAKNLQKLAKKFSKKPESGktslgtSWNSLREETESAATVHEELSEK------LSQLI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  977 IDKYSAFDEQEKQNiltRTKEKNDLRiKKEQELNQKIKELKEKALSDgqisenERKEIEKLENQRRDITVKELSKTEKEQ 1056
Cdd:cd07610    85 REPLEKVKEDKEQA---RKKELAEGE-KLKKKLQELWAKLAKKADEE------YREQVEKLNPAQSEYEEEKLNKIQAEQ 154

                         170
                  ....*....|...
gi 215401158 1057 ERILVRMQRNRNA 1069
Cdd:cd07610   155 EREEERLEILKDN 167
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 19-199 2.40e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.51  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKSS------ 92
Cdd:COG3883    28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSvsyldv 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   93 ----------------VKDVEKAYLKLVE---------ANKKEKlaLDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQ 147
Cdd:COG3883   108 llgsesfsdfldrlsaLSKIADADADLLEelkadkaelEAKKAE--LEAKLAELEALKAELEAAKAELEAQQAEQEALLA 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 215401158  148 KLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQ 199
Cdd:COG3883   186 QLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 922-1113 2.74e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   922 SEENSRIMEKVRLNSGQIS--EDKAKKLLKIETDlSNNLIAEIEKRNKKE------LEKT-----------QELIDKYSA 982
Cdd:pfam01576  151 SKERKLLEERISEFTSNLAeeEEKAKSLSKLKNK-HEAMISDLEERLKKEekgrqeLEKAkrklegestdlQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   983 FDEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISE------NERKEIEKLENQRRDITvKELS--KTEK 1054
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISElqedleSERAARNKAEKQRRDLG-EELEalKTEL 308

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215401158  1055 E---------QErilVRMQRNRnaySIDEASKAIKEAEKARKA-----RKK------EVDKQYEDdviAIKNNVNLSKS 1113
Cdd:pfam01576  309 EdtldttaaqQE---LRSKREQ---EVTELKKALEEETRSHEAqlqemRQKhtqaleELTEQLEQ---AKRNKANLEKA 378
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1-272 2.74e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158     1 MNEKVEGMTLELKldhlGVQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELK 80
Cdd:pfam01576  529 MKKKLEEDAGTLE----ALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQK 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    81 QVNANYQKAKS-SVKDVEKAYLKLVEANKKEKLALDKSKEAlkssnTELKKAENQYKRTNqrkqdayqklKQLRDAEQKL 159
Cdd:pfam01576  605 KFDQMLAEEKAiSARYAEERDRAEAEAREKETRALSLARAL-----EEALEAKEELERTN----------KQLRAEMEDL 669

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   160 KNSNQAT---TAQLKRASDAVQKQSAKHKALVEQYKQEGN-----------QVQKLKVQND-NLSKSNDKIESsyaktnt 224
Cdd:pfam01576  670 VSSKDDVgknVHELERSKRALEQQVEEMKTQLEELEDELQatedaklrlevNMQALKAQFErDLQARDEQGEE------- 742

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 215401158   225 KLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKAS 272
Cdd:pfam01576  743 KRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAAN 790
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
941-1219 2.75e-03

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 42.77  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  941 EDKAKKLLKIETDlsnnliaEIEKRNKKELEKTQELIDKYSafDEQEKQNILTRTKEKNDLRIKKEQELNqkiKELKEKA 1020
Cdd:COG5644   389 ERKAKRVAKIKSK-------TYRKIRKNRKEKEMALIPKSE--DLENEKSEEARALERMTQRHKNTSSWT---RKMLERA 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1021 LSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNaysIDEASKAIKEAE-----------KARKAR 1089
Cdd:COG5644   457 SHGEGTREAVNEQIRKGDELMQRIHGKEIMDGEDVSEFSDSDYDTNEQ---VSTAFEKIRNEEelkgvlgmkfmRDASNR 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1090 KKEVDKQYEDDVIAIKNNVNLSKSEKDKLLAIADQrhkdevrkAKSKKDAVVDVVKKQNKDID---KEMDLSSGRVYKNT 1166
Cdd:COG5644   534 QMAASKISVADLVKVENGDDIDVGELDEVGGDAIY--------ANAGRREVFPVVEQRRKLAPrkrKEDFVTPSTSLEKS 605

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 215401158 1167 EKWWNglkswwsnfrEDQKKKSDkyAKEQEETARRNRENIKKWFGNAWDGVKS 1219
Cdd:COG5644   606 MDRIL----------HGQKKRAE--GAVVFEKPLEATENFNPWLDRKMRRIKR 646
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
901-1055 3.08e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.54  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  901 KVLGKGVSKETEKALEKYVHYSEENSRIMEKVRLNSGQIsedkakKLLKIETDLSNNLIAEIEKRNKkELEKTQELIDKy 980
Cdd:COG2433   384 ELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQV------ERLEAEVEELEAELEEKDERIE-RLERELSEARS- 455

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  981 SAFDEQEKQNILTRTKEKNDlRIKKE-QELNQKIKELKEKalsdgqisENERKEIEKLENQRRDITVKELSKTEKE 1055
Cdd:COG2433   456 EERREIRKDREISRLDREIE-RLERElEEERERIEELKRK--------LERLKELWKLEHSGELVPVKVVEKFTKE 522
MapZ_EC1 pfam18041
MapZ extracellular domain 1; This is the extracellular domain 1 (MapZextra1) found in ...
 118-218 3.39e-03

MapZ extracellular domain 1; This is the extracellular domain 1 (MapZextra1) found in Streptococcus pneumoniae cell division site positioning protein MapZ. MapZ ensures accurate placement of the bacterial division site. The domain is a rigid four alpha-helices with two flexible linkers. The N-terminal end of MapZextra1 is connected to the trans-membrane segment of MapZ whilst the C-terminal is linked to MapZextra2 via a serine rich linker (SRL).The highly conserved residues are not accessible at the surface but are directly involved in many inter-helices interactions allowing for rigidity.


Pssm-ID: 465625 [Multi-domain]  Cd Length: 129  Bit Score: 39.62  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   118 KEALKSSNTELKKAENQYKRTNQRKQDAYqklkqLRDAEQKLKNSNqaTTAQLkrasDAVQKQSAKHKAlVEQYKQEGNQ 197
Cdd:pfam18041    1 QESETASSQELKKEDANLDAFEKEYDAFY-----TDDEHTFLKNSE--FAAQL----SKLQKQLEKLKD-SKYYDKLKTK 68

                           90       100
                   ....*....|....*....|.
gi 215401158   198 VQKLKVQNDNLSKSNDKIESS 218
Cdd:pfam18041   69 LDSLKDQIAAIQKVNGKFTSP 89
PLN02372 PLN02372
violaxanthin de-epoxidase
 950-1058 3.96e-03

violaxanthin de-epoxidase


Pssm-ID: 215212 [Multi-domain]  Cd Length: 455  Bit Score: 42.14  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  950 IETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQE--KQNILTRTKEKNDLrikKEQELNQKIKELKEKALSDGQ-I 1026
Cdd:PLN02372  350 VRTDNTCGPEPPLLERLEKDVEEGEKTIVKEARQIEEEleKEVEKLGKEEESLF---KRVALEEGLKELEQDEENFLKeL 426

                          90       100       110
                  ....*....|....*....|....*....|..
gi 215401158 1027 SENERKEIEKLEnqrrditvKELSKTEKEQER 1058
Cdd:PLN02372  427 SKEEKELLEKLK--------MEASEVEKLFGR 450
TACC_C pfam05010
Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a ...
 49-214 4.52e-03

Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organizing centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1). TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis. Maskin is also found to bind CPEB and elF-4E. Interestingly, the functional homolog (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organization of bipolar spindles.


Pssm-ID: 461517 [Multi-domain]  Cd Length: 201  Bit Score: 40.43  E-value: 4.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    49 KSMEKYQARIKGLNDRLKVQKKMYSQvedELKQVNANYQKAKSSVKDVEKAYLKLVEANKKEKLALdkskEALKSSNTEL 128
Cdd:pfam05010   43 KIVAEFEKTIAQMIEEKQKQKELEHA---EIQKVLEEKDQALADLNSVEKSFSDLFKRYEKQKEVI----SGYKKNEESL 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   129 KKAENQYKRTNQRKQDAYQKLKQlrDAEQKLKNSNqATTAQLKRasdavqKQSAKHKALVEQYKQEGNQVQKLKVQNDNL 208
Cdd:pfam05010  116 KKCAQDYLARIKKEEQRYQALKA--HAEEKLDQAN-EEIAQVRS------KAKAETAALQASLRKEQMKVQSLERQLEQK 186


                   ....*.
gi 215401158   209 SKSNDK 214
Cdd:pfam05010  187 TKENEE 192
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 19-285 4.56e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    19 VQEGMKGLKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKvqkkmysqvEDELKQVNANYQKAKSSVKDVEK 98
Cdd:TIGR02169  742 LEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLS---------HSRIPEIQAELSKLEEEVSRIEA 812

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    99 AylkLVEANKKEKlALDKSKEALkssntelkkaenqykrtnqrkQDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQ 178
Cdd:TIGR02169  813 R---LREIEQKLN-RLTLEKEYL---------------------EKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE 867

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   179 KQSAKHKALVEQYkqeGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEK 258
Cdd:TIGR02169  868 EELEELEAALRDL---ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE 944

                          250       260       270
                   ....*....|....*....|....*....|...
gi 215401158   259 ------AALNNLERSIDKASSEMKTFNKEQMIA 285
Cdd:TIGR02169  945 eipeeeLSLEDVQAELQRVEEEIRALEPVNMLA 977
46 PHA02562
endonuclease subunit; Provisional
 6-222 4.65e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    6 EGMTLELKLDHlgVQEGMKGLKRQLGVVNSEMKANL----SAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQ 81
Cdd:PHA02562  182 QIQTLDMKIDH--IQQQIKTYNKNIEEQRKKNGENIarkqNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNK 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   82 VNANYQKAKSSVKD---VEKAYLK----------------LVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRK 142
Cdd:PHA02562  260 LNTAAAKIKSKIEQfqkVIKMYEKggvcptctqqisegpdRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKL 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  143 QDAYQKLKQLRDAEQKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKT 222
Cdd:PHA02562  340 LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKDSGIKA 419
Caldesmon pfam02029
Caldesmon;
909-1138 4.70e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.78  E-value: 4.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   909 KETEKALEKYVHYSEENSRIMEKVRLNSGQISEDKAK---KLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDE 985
Cdd:pfam02029   77 KRLQEALERQKEFDPTIADEKESVAERKENNEEEENSsweKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   986 QEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQR 1065
Cdd:pfam02029  157 EEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQER 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1066 NRNAYSIDEASKAIKE-----AEKARKARKKEVDKQYEddviAIKNNVNLSKS--EKDKLLAIADQRHKDEVRKAKSKKD 1138
Cdd:pfam02029  237 EEEAEVFLEAEQKLEElrrrrQEKESEEFEKLRQKQQE----AELELEELKKKreERRKLLEEEEQRRKQEEAERKLREE 312
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 75-272 4.93e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 41.94  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    75 VEDELKQVNANYQKAKS----SVKDVEKAYLKLVEANKK-EKLA--LDKSKEALKSSNTELKKAENQYKRTN-QRKQDAY 146
Cdd:pfam05701  143 VKEELESLRKEYASLVSerdiAIKRAEEAVSASKEIEKTvEELTieLIATKESLESAHAAHLEAEEHRIGAAlAREQDKL 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   147 QKLKQLRDAEQKLKNSNQATTAQ------LKRASDAVQKQSAKHKALVEqykqegNQVQKLKVQNDNLSKSNDKIESsya 220
Cdd:pfam05701  223 NWEKELKQAEEELQRLNQQLLSAkdlkskLETASALLLDLKAELAAYME------SKLKEEADGEGNEKKTSTSIQA--- 293

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158   221 ktntKLKQTEKEFNDLNntiknhsANVAKAETAVN--------------KEKAALNNLERSIDKAS 272
Cdd:pfam05701  294 ----ALASAKKELEEVK-------ANIEKAKDEVNclrvaaaslrseleKEKAELASLRQREGMAS 348
Ax_dynein_light pfam10211
Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in ...
 74-172 4.98e-03

Axonemal dynein light chain; Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organizms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.


Pssm-ID: 463000 [Multi-domain]  Cd Length: 187  Bit Score: 40.25  E-value: 4.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    74 QVEDELKQVNANYQK-AKSSV----KDVEKAYLKLVEANKKEKlALDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQK 148
Cdd:pfam10211   87 RVRDELRMTIAAYQTlYESSVafgmRKALQAEQGKAELEKKIA-DLEEEKEELEKQVAELKAKCEAIEKREEERRQAEEK 165

                           90       100
                   ....*....|....*....|....
gi 215401158   149 LKQlrDAEQKLKNSNQATTAQLKR 172
Cdd:pfam10211  166 KHA--EEIAFLKKTNQQLKAQLER 187
Utp11 pfam03998
Utp11 protein; This protein is found to be part of a large ribonucleoprotein complex ...
 984-1164 5.03e-03

Utp11 protein; This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome.


Pssm-ID: 461122 [Multi-domain]  Cd Length: 241  Bit Score: 40.68  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   984 DEQEKQNILTRTKEK----ND-------LRIKKEQELNQKIKELKEKALSDGQIS--------------ENERKEIEKLE 1038
Cdd:pfam03998   31 DYHKKQATLKALREKaaerNPdefyfgmISSKTDDGVHVLVNKDRGNALSVDQVKllktqdlgyvrtkrQIERKKIEKLE 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1039 NQRRDITVkELSKTEKEQERILVRMQRNRNAYSIDEASKAIKEAEKARKARKKEVDKQYEDDVIAIKNNVNLSKSEKDKL 1118
Cdd:pfam03998  111 EELHLLDA-GVKNEKKNKHTVFVDSEEEVKNFDPAEYFDTDPELLDRRENRLKKEQLESNSLTAATLKKLDKKKEKLYKE 189

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 215401158  1119 LAIADQRHKD--------EVRKAKSKKDAVVDVVKKQNKdidkemdlsSGRVYK 1164
Cdd:pfam03998  190 LKARLEREKElkkaeqklELQRALMKKGAKKKVKGGTTK---------KGPVYK 234
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 185-271 5.16e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 41.25  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   185 KALVEQYKQEGNQVQKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNT--------IKNHSANVAKAETAVNK 256
Cdd:TIGR04320  257 AALQAKLATAQADLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQAQalqtaqnnLATAQAALANAEARLAK 336

                           90
                   ....*....|....*
gi 215401158   257 EKAALNNLERSIDKA 271
Cdd:TIGR04320  337 AKEALANLNADLAKK 351
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 929-1100 5.20e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 5.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   929 MEKVRLNSGQISEDKAK-KLLKIETDL--SNNLIAEIEKR---NKKELEKTQ-ELIDKYSAFdEQEKQNILTRTKEKNDL 1001
Cdd:pfam12128  587 LKRIDVPEWAASEEELReRLDKAEEALqsAREKQAAAEEQlvqANGELEKASrEETFARTAL-KNARLDLRRLFDEKQSE 665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1002 RIKKEQELNQKIKELKEKALS-DGQISENERKEIEKLENQRRDItvKELSkTEKEQERILVRMQRNRNAYSIDEAskaIK 1080
Cdd:pfam12128  666 KDKKNKALAERKDSANERLNSlEAQLKQLDKKHQAWLEEQKEQK--REAR-TEKQAYWQVVEGALDAQLALLKAA---IA 739

                          170       180
                   ....*....|....*....|
gi 215401158  1081 EAEKARKARKKEVDKQYEDD 1100
Cdd:pfam12128  740 ARRSGAKAELKALETWYKRD 759
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 939-1159 5.23e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  939 ISEDKAKK---LLKIEtDLSNNL------IAEIEKR--------NK----KELEKTQELIDKYSAF--------DEQEKQ 989
Cdd:COG1196   167 ISKYKERKeeaERKLE-ATEENLerlediLGELERQleplerqaEKaeryRELKEELKELEAELLLlklreleaELEELE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  990 NILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQ----ISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQR 1065
Cdd:COG1196   246 AELEELEAELEELEAELAELEAELEELRLELEELELeleeAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1066 NRNAYSIDEASKAIKEAEKARKARKKEVDkqyeddviAIKNNVNLSKSEKDKLLAIADQRHKDEVRKAKSKKDAVVDVVK 1145
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELE--------EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE 397

                         250
                  ....*....|....
gi 215401158 1146 KQNKDIDKEMDLSS 1159
Cdd:COG1196   398 LAAQLEELEEAEEA 411
PTZ00121 PTZ00121
MAEBL; Provisional
 46-276 5.23e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   46 KSEKSMEKYQARIKGlnDRLKVQKKMYSQVEDELKQVNANYQKAKSSVKDVEKAylKLVEANKKEKL----ALDKSKEAL 121
Cdd:PTZ00121 1471 KADEAKKKAEEAKKA--DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAK--KADEAKKAEEAkkadEAKKAEEKK 1546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  122 KSSNT----ELKKAEN-----QYKRTNQRKQDAYQKLKQLRDAEQK--------LKNSNQATTAQLKRASDA-------- 176
Cdd:PTZ00121 1547 KADELkkaeELKKAEEkkkaeEAKKAEEDKNMALRKAEEAKKAEEArieevmklYEEEKKMKAEEAKKAEEAkikaeelk 1626

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  177 ----VQKQSAKHKALVEQYKQEGNQVQK----LKVQNDNLSKSND----------KIESSYAKTNTKLKQTEKEFNDLNN 238
Cdd:PTZ00121 1627 kaeeEKKKVEQLKKKEAEEKKKAEELKKaeeeNKIKAAEEAKKAEedkkkaeeakKAEEDEKKAAEALKKEAEEAKKAEE 1706

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 215401158  239 TIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMK 276
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKK 1744
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 224-503 5.31e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  224 TKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQMIAQShfgKLASQADVMSKKF 303
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEA---EIEERREELGERA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  304 SSI---GDKMTSLgrtmtmgvstpitlglgAALKTSADFEGQMSRVGAIAQASSKDLKSMSNQAVDLGAKTSKSAnEVAK 380
Cdd:COG3883    93 RALyrsGGSVSYL-----------------DVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKA-ELEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  381 GMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFGLKASDANHVADLLARSANDSAADIQYMGDALK 460
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAA 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 215401158  461 YAGTPAKAlGVSIEDTSAAIEVLSNSGLEGSQAGTALRASFIR 503
Cdd:COG3883   235 AAAAAAAA-AASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGA 276
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 27-318 5.36e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.13  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   27 KRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQV------------NANYQKAKSSVK 94
Cdd:PTZ00440 2208 KKKNIINNIYKKINFIKLQEIENSSEKYNDISKLFNNVVETQKKKLLDNKNKINNIkdkindkekeliNVDSSFTLESIK 2287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   95 DVEKAYLKLVEANKKEKLALDKSKEALKSSNTELKKAENQYKRTNQRKQDA--YQKLKQLRDAEQKLKNSNQATTAQLKR 172
Cdd:PTZ00440 2288 TFNEIYDDIKSNIGDLYKLEDTNNDELKKVKLYIENITHLLNRINTLINDLdnYQDENYGKDKNIELNNENNSYIIKTKE 2367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  173 ASDAVQKQSAKHKALVEQYKQEGNQVQKLKVQNDNLSKSNDKIE--SSYAKTNTKLKQTEKEFNDLNN------TIKNHS 244
Cdd:PTZ00440 2368 KINNLKEEFSKLLKNIKRNNTLCNNNNIKDFISNIGKSVETIKQrfSSNLPEKEKLHQIEENLNEIKNimnetkRISNVD 2447

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215401158  245 ANVAKAETAVNKEKAALNNLE--RSIDKASSEMKTFNKEqmiAQSHFgklaSQADVMSKKFSSIGDKMTSLGRTMT 318
Cdd:PTZ00440 2448 AFTNKILQDIDNEKNKENNNMnaEKIDDLIENVTSHNEK---IKSEL----LIINDALRRVKEKKDEMNKLFNSLT 2516
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 949-1138 5.41e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.56  E-value: 5.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   949 KIETDLSNNLIAEIEKRNKKELEKTQELIdKYSA----FDEQEKQNILTR--TKEKNDLRIKKEQELNQKIK--ELKEKA 1020
Cdd:pfam15558  150 RLEEACHKRQLKEREEQKKVQENNLSELL-NHQArkvlVDCQAKAEELLRrlSLEQSLQRSQENYEQLVEERhrELREKA 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1021 lsdgqiseneRKEIEKLENQRRdiTVKELSKTEKEQERILVRM--QRNRNAYSIdeASKAIKeaEKARKARKKEVDKQye 1098
Cdd:pfam15558  229 ----------QKEEEQFQRAKW--RAEEKEEERQEHKEALAELadRKIQQARQV--AHKTVQ--DKAQRARELNLERE-- 290

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 215401158  1099 ddviaiKNN-VNLSKSEKDkllaiaDQRHKDEVRKAKSKKD 1138
Cdd:pfam15558  291 ------KNHhILKLKVEKE------EKCHREGIKEAIKKKE 319
YscO-like pfam16789
YscO-like protein; This family of proteins is similar to the type III secretion protein YscO. ...
 927-1059 5.84e-03

YscO-like protein; This family of proteins is similar to the type III secretion protein YscO. The family includes Chlamydia trachomatis CT670 which is found in a type III secretion gene cluster. CT670 interacts with CT671, a putative YscP homolog and CT670 and CT671 may form a chaperone-effector pair.


Pssm-ID: 435583 [Multi-domain]  Cd Length: 160  Bit Score: 39.43  E-value: 5.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   927 RIMEKVRLNSGQISEDKaKKLLKIETDLSNNLIAEIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKE 1006
Cdd:pfam16789   10 DIKKKRVEEAEKVVKDK-KRALEKEKEKLAELEAERDKVRKHKKAKMQQLRDEMDRGTTSDKILQMKRYIKVVKERLKQE 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 215401158  1007 QELNQKIKELKEKALSDGQISENE----RKEIEKLENQRRDItVKELSKTEKEQERI 1059
Cdd:pfam16789   89 EKKVQDQKEQVRTAARNLEIAREElkkkRQEVEKLEKHKKEW-VKEMKKEEEDQEER 144
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 50-300 5.92e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.96  E-value: 5.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    50 SMEKYQ------ARIKGLNDRLKVQKKMYSQVEDELKQvnaNYQKAKSSVKDVEKAYLKLVEANKKeKLALDKSKEALKS 123
Cdd:TIGR01612  511 FMELYKpdevpsKNIIGFDIDQNIKAKLYKEIEAGLKE---SYELAKNWKKLIHEIKKELEEENED-SIHLEKEIKDLFD 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   124 SNTELKKaENQYkrTNQRKQDAYQKLKQLRDaeqklKNSnqattaQLKRASDAvqkqsakhKALVEQYKQEGNQVQKLK- 202
Cdd:TIGR01612  587 KYLEIDD-EIIY--INKLKLELKEKIKNISD-----KNE------YIKKAIDL--------KKIIENNNAYIDELAKISp 644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   203 VQNDNLSKSNDKIESSYAKTNTKLKQ--TEKEFNDLNNTIKnhsanvakaETAVN--KEKAALNNLERSIDKASSEMKtf 278
Cdd:TIGR01612  645 YQVPEHLKNKDKIYSTIKSELSKIYEddIDALYNELSSIVK---------ENAIDntEDKAKLDDLKSKIDKEYDKIQ-- 713

                          250       260
                   ....*....|....*....|..
gi 215401158   279 NKEQMIAQSHFGKLASQADVMS 300
Cdd:TIGR01612  714 NMETATVELHLSNIENKKNELL 735
PRK11637 PRK11637
AmiB activator; Provisional
 168-271 6.09e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 41.22  E-value: 6.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  168 AQLKrasDAVQKQSAKHKALVEQYKQEGNQVQKLKVQndnlsksndkiESSYAKTNTKLKQTEKEFNDLNNTIKNHSANV 247
Cdd:PRK11637   47 DQLK---SIQQDIAAKEKSVRQQQQQRASLLAQLKKQ-----------EEAISQASRKLRETQNTLNQLNKQIDELNASI 112

                          90       100
                  ....*....|....*....|....
gi 215401158  248 AKAETavnKEKAALNNLERSIDKA 271
Cdd:PRK11637  113 AKLEQ---QQAAQERLLAAQLDAA 133
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
938-1139 6.31e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 41.40  E-value: 6.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  938 QISEDKAKKLLKIETDLSNNLiaeieKRNKKELE--KTQELIDKYSAFDEQEKQNIltrTKEKNDLRIKK-EQELNQKIk 1014
Cdd:COG2268   144 ELNEDREKFAEKVQEVAGTDL-----AKNGLELEsvAITDLEDENNYLDALGRRKI---AEIIRDARIAEaEAERETEI- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1015 elkekalsdgQISENERKEIEKLENQRRDITVKELSKTEKEQERILVRMQRNRNAYSIdeasKAIKEAEKARKARKKEVD 1094
Cdd:COG2268   215 ----------AIAQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAETARA----EAEAAYEIAEANAEREVQ 280

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 215401158 1095 KQYEddVIAIKNNVNLSKSEKDKLLA--IADQRHKDEVRKAKSKKDA 1139
Cdd:COG2268   281 RQLE--IAEREREIELQEKEAEREEAelEADVRKPAEAEKQAAEAEA 325
Caldesmon pfam02029
Caldesmon;
961-1151 6.34e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.39  E-value: 6.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   961 EIEKRNKKELEKTQELIDKYSAFDEQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKALSDGQISENERKEIEKLEN- 1039
Cdd:pfam02029   34 ESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEALERQKEFDPTIADEKESVAERKENNEEEENs 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1040 --QRRDITVKELSKTEKEQERILVRmQRNRNAYSIDEASKAIKEAEKARKARK-KEVDKQYEDDVIAIKNNVNLSKSEKD 1116
Cdd:pfam02029  114 swEKEEKRDSRLGRYKEEETEIREK-EYQENKWSTEVRQAEEEGEEEEDKSEEaEEVPTENFAKEEVKDEKIKKEKKVKY 192

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 215401158  1117 KLLAIADQRHKDEVRKAKSKKDAVVDVVKKQNKDI 1151
Cdd:pfam02029  193 ESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQ 227
PRK01156 PRK01156
chromosome segregation protein; Provisional
 26-300 6.74e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.43  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   26 LKRQLGVVNSEMKANLSAFDKSEKSMEKYQARIKGLNDRLKVQKKMYSQVEDELKQVNANYQKAKssvkdveKAYLKLVE 105
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKN-------RYESEIKT 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  106 ANKKEKLALDKSKEaLKSSNTELKKAENQYKRTNQRKQDAYQKLK-QLRDAEQKLKNSNqattAQLKRASDAVQKqSAKH 184
Cdd:PRK01156  261 AESDLSMELEKNNY-YKELEERHMKIINDPVYKNRNYINDYFKYKnDIENKKQILSNID----AEINKYHAIIKK-LSVL 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  185 KALVEQYKQEGNQVQKLKVQNDNLSKSNDKIES---SYAKTNTKLKQTEKEFNDLNNTIknhSANVAKAETAVNKEKAAL 261
Cdd:PRK01156  335 QKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSylkSIESLKKKIEEYSKNIERMSAFI---SEILKIQEIDPDAIKKEL 411

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 215401158  262 NNLERSIDKASSEMKTFNKEQMIAQSHFGKLASQADVMS 300
Cdd:PRK01156  412 NEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLN 450
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 114-428 7.83e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  114 LDKSKEALKSSNTELKKAENQYKRTNQRKQDAYQKLKQLRdaeqklknsnqattAQLKRASDAVQKQSAKHKALVEQYKQ 193
Cdd:COG3883    32 LEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQ--------------AEIAEAEAEIEERREELGERARALYR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  194 EGNQVQKLKV--QNDNLSKSNDKIESS---YAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKAALNNLERSI 268
Cdd:COG3883    98 SGGSVSYLDVllGSESFSDFLDRLSALskiADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQ 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  269 DKASSEMKTFNKEQMIAQSHFGKLASQADVMSKKFSSIGDKMTSLGRTMTMGVSTPITLGLGAALKTSADFEGQMSRVGA 348
Cdd:COG3883   178 AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  349 IAQASSKDLKSMSNQAVDLGAKTSKSANEVAKGMEELAALGFNAKQTMEAMPGVISAAEASGAEMATTATVMASAINSFG 428
Cdd:COG3883   258 AAGSAGAAGAAAGAAGAGAAAASAAGGGAGGAGGGGGGGGAASGGSGGGSGGAGGVGSGGGAGAVVGGASAGGGGGSGGG 337
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
985-1153 8.23e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 8.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  985 EQEKQNILTRTKEKNDLRIKKEQELNQKIKELKEKAlsdGQISENE------RKEIEKLENQRRDITvKELSKTEKE--- 1055
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKE---EEYAELQeeleelEEELEELEAELEELR-EELEKLEKLlql 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158 1056 ----QERILVRMQRNRNAYSIDEAS---KAIKEAEKARKARKKEVdKQYEDDVIAIKNNVNLSKSEKDKLLAIADQRHKD 1128
Cdd:COG4717   128 lplyQELEALEAELAELPERLEELEerlEELRELEEELEELEAEL-AELQEELEELLEQLSLATEEELQDLAEELEELQQ 206

                         170       180
                  ....*....|....*....|....*
gi 215401158 1129 EVRKAKSKKDAVVDVVKKQNKDIDK 1153
Cdd:COG4717   207 RLAELEEELEEAQEELEELEEELEQ 231
PRK12704 PRK12704
phosphodiesterase; Provisional
 170-282 8.77e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  170 LKRASDAVQKQsAKHKA--LVEQYKQEGNQVQKLKV--QNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSA 245
Cdd:PRK12704   25 RKKIAEAKIKE-AEEEAkrILEEAKKEAEAIKKEALleAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 215401158  246 NVAKAETAVNKEKAALNNLERSIDKASSEMKTFNKEQ 282
Cdd:PRK12704  104 LLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQ 140
Filament pfam00038
Intermediate filament protein;
55-183 8.97e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.67  E-value: 8.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    55 QARIKGLNDRLKVQKKMY--------SQVEDELKQV---NANYQKAKSSVKDVEKAYLKLVEANKKE------------K 111
Cdd:pfam00038  123 EAKIESLKEELAFLKKNHeeevrelqAQVSDTQVNVemdAARKLDLTSALAEIRAQYEEIAAKNREEaeewyqskleelQ 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   112 LALDKSKEALKSSNTELkkaeNQYKRTNQRKQ---DAYQKLK-----QLRDAEQKLknSNQATTAQLKRASDAVQKQSAK 183
Cdd:pfam00038  203 QAAARNGDALRSAKEEI----TELRRTIQSLEielQSLKKQKaslerQLAETEERY--ELQLADYQELISELEAELQETR 276
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 945-1167 9.30e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.99  E-value: 9.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   945 KKLLKIETDLSNNL--IAEIE-KRNKKELEKTQELIDK-YSAFdEQE---KQNIltrtkEKNDLRIKKE-QELNQKIKEL 1016
Cdd:pfam06160  237 KEIQQLEEQLEENLalLENLElDEAEEALEEIEERIDQlYDLL-EKEvdaKKYV-----EKNLPEIEDYlEHAEEQNKEL 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1017 KEK--ALSDG-QISENERKEIEKLEnqrrditvKELSKTEKEQERILVRMQRNRNAYS--------IDEASKAIKE---- 1081
Cdd:pfam06160  311 KEEleRVQQSyTLNENELERVRGLE--------KQLEELEKRYDEIVERLEEKEVAYSelqeeleeILEQLEEIEEeqee 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158  1082 -AEKARKARKKEVD-----KQYEDDVIAIK---NNVNLSKSEKDKLLAIADQRHK-DEVRKAKSKKDAVVDVVKKQNKDI 1151
Cdd:pfam06160  383 fKESLQSLRKDELEareklDEFKLELREIKrlvEKSNLPGLPESYLDYFFDVSDEiEDLADELNEVPLNMDEVNRLLDEA 462

                          250
                   ....*....|....*.
gi 215401158  1152 DKEMDlssgRVYKNTE 1167
Cdd:pfam06160  463 QDDVD----TLYEKTE 474
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 36-318 9.35e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.19  E-value: 9.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158    36 EMKANLSAFDKSEKSMEKYQARIKglndrlKVQKKMYSQVEDELKQVNANYQkakSSVKDVEKaylKLVEANKK-EKlaL 114
Cdd:TIGR00606  266 KLDNEIKALKSRKKQMEKDNSELE------LKMEKVFQGTDEQLNDLYHNHQ---RTVREKER---ELVDCQRElEK--L 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   115 DKSKEALKSSNTELkkaENQYKRTnQRKQDAYQKLKQLRDAEqKLKNSNQATTAQLKRASDAVQKQSAKHKALVEQYKQE 194
Cdd:TIGR00606  332 NKERRLLNQEKTEL---LVEQGRL-QLQADRHQEHIRARDSL-IQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDE 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215401158   195 GNQV--------QKLKVQNDNLSKSNDKIESSYAKTNTKLKQTEKEFNDLNNTIKNHSANVAKAETAVNKEKaALNNLER 266
Cdd:TIGR00606  407 AKTAaqlcadlqSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQ-ELRKAER 485

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 215401158   267 SIDKA--SSEMKTFNKEQMIAQShfgklaSQADVMsKKFSSIGDKMTSLGRTMT 318
Cdd:TIGR00606  486 ELSKAekNSLTETLKKEVKSLQN------EKADLD-RKLRKLDQEMEQLNHHTT 532
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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