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Conserved domains on  [gi|215272319|ref|NP_001135816|]
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chemerin-like receptor 1 isoform a [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606829)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
41-327 8.63e-158

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


:

Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 444.59  E-value: 8.63e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTP 198
Cdd:cd15116   81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFNNFSLSGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15116  161 NSSPE-----VNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 279 LNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFK 327
Cdd:cd15116  236 LNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
 
Name Accession Description Interval E-value
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
41-327 8.63e-158

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 444.59  E-value: 8.63e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTP 198
Cdd:cd15116   81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFNNFSLSGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15116  161 NSSPE-----VNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 279 LNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFK 327
Cdd:cd15116  236 LNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-316 2.22e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 153.61  E-value: 2.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319   57 GNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIIS 134
Cdd:pfam00001   1 GNLLVIlVILRNKKLRTPTNIFLLNLAVADLLFSLLtLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  135 SDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkisCFNNFSLSTPGSSSWPTHSqmdpvgy 214
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT--------LTVPEGNVTVCFIDFPEDL------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  215 SRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT--------KKPFKIIVTIIITFFLCWCPYHTLNLLELHH 286
Cdd:pfam00001 146 SKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKssertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLA 225
                         250       260       270
                  ....*....|....*....|....*....|.
gi 215272319  287 TAMPGS-VFSLGLPLATALAIANSCMNPILY 316
Cdd:pfam00001 226 LDCELSrLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
14-327 6.29e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 128.36  E-value: 6.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  14 YGDEYPDYLDSIVvledlspleARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLP 93
Cdd:PHA03087  23 YDEDYADCDLNIG---------YDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLP 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  94 IHITYAAMDyHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSP 173
Cdd:PHA03087  94 FQIYYYILF-QWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 174 SLVFRDTANLHGKISCFNNFSlstPGSSSWPthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-NRL 252
Cdd:PHA03087 173 ILFVYTTKKDHETLICCMFYN---NKTMNWK-------------LFINFEINIIGMLIPLTILLYCYSKILITLKGiNKS 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 253 AKTKKPFKIIVTIIITFFLCWCPYH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:PHA03087 237 KKNKKAIKLVLIIVILFVIFWLPFNvsvfvySLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKH 316

                 .
gi 215272319 327 K 327
Cdd:PHA03087 317 K 317
 
Name Accession Description Interval E-value
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
41-327 8.63e-158

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 444.59  E-value: 8.63e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTP 198
Cdd:cd15116   81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFNNFSLSGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15116  161 NSSPE-----VNQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 279 LNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFK 327
Cdd:cd15116  236 LNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
41-327 1.86e-130

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 374.72  E-value: 1.86e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpgs 200
Cdd:cd14974   81 LNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSC----------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 ssWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd14974  150 --NLTCVEDYDLRRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFA 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 281 LLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFK 327
Cdd:cd14974  228 LLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
41-325 1.12e-84

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 258.90  E-value: 1.12e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15117    1 ILSLVIYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSlstPGS 200
Cdd:cd15117   81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFD---PWN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15117  158 ETAEDPVLWLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 281 LLELHHTAMP----GSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15117  238 LLELVVILNQkedlNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRE 286
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
41-324 1.43e-80

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 247.73  E-value: 1.43e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANL-HGKISCFNNFslstpg 199
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNF------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswptHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15119  155 ------HKHDGDLIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIF 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 280 NLLEL--HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15119  229 SILELsiHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
41-325 2.37e-78

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 241.60  E-value: 2.37e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpgs 200
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRC----------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 sswpthsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAK-TKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15115  150 ------------GYDFLVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKsQSKTFRVIIAVVVAFFVCWAPYHII 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 280 NLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15115  218 GILSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
41-325 1.08e-69

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 219.97  E-value: 1.08e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTp 198
Cdd:cd15114   81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHfpEKTVCVVDYGGST- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15114  160 ----------------GVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 279 LNLLELHHTamPGSVFSLGL----PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15114  224 VGLIIAASA--PNSRLLANAlkadPLTVSLAYINSCLNPIIYVVAGRGFRK 272
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
43-327 1.48e-65

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 209.64  E-value: 1.48e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFL-GILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15120    2 LIAVALFVTFLvGLVVNGLYLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCFNNFSLSTPGS 200
Cdd:cd15120   82 GMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEkGKTICQNNYALSTNWE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SswpthSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15120  162 S-----AEVQASRQWIHVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 281 LLELhHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFK 327
Cdd:cd15120  237 GLVL-TRGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
41-323 2.32e-60

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 196.18  E-value: 2.32e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15118    1 VATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCFNNFSLSTPG 199
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKdGRKLCYYNFALFSPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSwpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15118  161 PDN------NHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIF 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 280 NLLELHHTAMPGS--VFSLGLPLATALAIANSCMNPILYVFMGQDF 323
Cdd:cd15118  235 SIIEVMAHNQHSLrpLVIQGLPFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
41-325 1.99e-53

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 177.79  E-value: 1.99e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLlVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA--DGWVFGSFLCKLVSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTpg 199
Cdd:cd14984   79 TINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDT-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd14984  157 ATTWK-------------TLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 280 NLLE-LHHTAMPGS------VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14984  224 LLLDtLQLLGIISRscelskSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
42-325 1.72e-52

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 175.64  E-value: 1.72e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd14985    2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGpKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVIS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG--KISCFNNFSlstp 198
Cdd:cd14985   82 VNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENlnKTACIMLYP---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKL------QRNRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd14985  158 -HEAW-------------HFGLSLELNILGFVLPLLIILTCYFHIARSLrkryerTGKNGRKRRKSLKIIFALVVAFLVC 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 273 WCPYHTLNLLEL------HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14985  224 WLPFHFFKFLDFlaqlgaIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
41-325 3.30e-52

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 174.79  E-value: 3.30e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIyVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTA-NLHGKISCfnnfslstp 198
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLqEEGGTISC--------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPTHSQMDpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRL----------AKTKKPFKIIVTIIIT 268
Cdd:cd14970  151 -NLQWPDPPDYW------GRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNlstsgarekrRARRKVTRLVLVVVAV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 269 FFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14970  224 FVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
41-325 4.32e-47

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 161.83  E-value: 4.32e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKlKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscFNNFSLSTPG 199
Cdd:cd15192   81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFF-------IENTNITVCA 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMdPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP-----FKIIVTIIITFFLCWC 274
Cdd:cd15192  154 FHYPSQNSTL-LVGLG------LMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPrndeiFKMIMAVVLFFFFCWI 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 275 PYHTLNLLE-------LHHTAMPgSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15192  227 PHQIFTFLDvliqlkvIQDCHIA-DIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRK 283
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-325 1.49e-45

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 158.39  E-value: 1.49e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIaTFKMK---KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15190   15 VIYMLVFVLGLSGNGLVLWT-VFRSKrkrRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG--KISCFNNFSLSTPG 199
Cdd:cd15190   94 NMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGtnKVICDMDYSGVVSN 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsqMDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVC-------KLQRNRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15190  174 ESEW-----AWIAGLG------LSSTVLGFLLPFLIMLTCYFFIGRtvarhfsKLRRKEDKKKRRLLKIIITLVVTFALC 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 273 WCPYHTL----NLLELHHTAMPGSV---FSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15190  243 WLPFHLVktlyALMYLGILPFSCGFdlfLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
41-325 7.50e-45

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 155.89  E-value: 7.50e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKrSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN-LHGKISCFNNFSlstp 198
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAkENNSTTCFEFLS---- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmDPVGYSRHMVVTVTRFlcGFLVPVLIITACYLTIVCKLQRNRLAKT-----KKPFKIIVTIIITFFLCW 273
Cdd:cd14982  157 -----------EWLASAAPIVLIALVV--GFLIPLLIILVCYSLIIRALRRRSKQSQksvrkRKALRMILIVLAVFLVCF 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 274 CPYHTLNLL-------ELHHTAMPGSVFSLgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14982  224 LPYHVTRILyllvrlsFIADCSARNSLYKA-YRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-316 2.22e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 153.61  E-value: 2.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319   57 GNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIIS 134
Cdd:pfam00001   1 GNLLVIlVILRNKKLRTPTNIFLLNLAVADLLFSLLtLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  135 SDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkisCFNNFSLSTPGSSSWPTHSqmdpvgy 214
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT--------LTVPEGNVTVCFIDFPEDL------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  215 SRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT--------KKPFKIIVTIIITFFLCWCPYHTLNLLELHH 286
Cdd:pfam00001 146 SKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKssertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLA 225
                         250       260       270
                  ....*....|....*....|....*....|.
gi 215272319  287 TAMPGS-VFSLGLPLATALAIANSCMNPILY 316
Cdd:pfam00001 226 LDCELSrLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-326 5.69e-44

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 153.39  E-value: 5.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLL 119
Cdd:cd15093    1 VLIPCIYAVVCLVGLCGNSLVIyVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKISCFNNfslstp 198
Cdd:cd15093   80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTrENQDGSSACNMQ------ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gsssWPthsqmDPVGYSRHMVVTVTrFLCGFLVPVLIITACYLTIVCKLQ--------RNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd15093  154 ----WP-----EPAAAWSAGFIIYT-FVLGFLLPLLIICLCYLLIVIKVKsaglragwQQRKRSERKVTRMVVMVVVVFV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15093  224 ICWLPFYVLQLVNVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKS 279
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
41-325 6.25e-44

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 153.20  E-value: 6.25e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVlVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVV--KGWIFGTFMCKLVSLLQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLST 197
Cdd:cd15178   79 EANFYSGILLLACISVDRYLAIVHATRALTQKR-HLVKFVCAGVWLLSLLLSLPALLNRDAFKPPnsGRTVCYENLGNES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgSSSWpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYh 277
Cdd:cd15178  158 --ADKW-------------RVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPY- 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 278 tlNLLELHHTAMPGSVFS----------LGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15178  222 --NVTVLIDTLMRTKLITetcelrnhvdVALYVTQILGFLHSCINPVLYAFIGQKFRN 277
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
41-323 1.08e-42

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 150.16  E-value: 1.08e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPwNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNnfsLSTPG 199
Cdd:cd15168   81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYD---TTSPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSwpthsqmDPVGYSrhMVVTVTrflcGFLVPVLIITACYLTIVCKLQR------NRLAKtKKPFKIIVTIIITFFLCW 273
Cdd:cd15168  158 ELN-------DYVIYS--MVLTGL----GFLLPLLIILACYGLIVRALIRklgegvTSALR-RKSIRLVIIVLALFAVCF 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 274 CPYH---TLNL----LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDF 323
Cdd:cd15168  224 LPFHvtrTINLaarlLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKF 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
41-325 2.62e-42

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 149.14  E-value: 2.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLyVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF-RDTANLHGKISCFnnFSLSTP 198
Cdd:cd15088   81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYsSLIYFPDGTTFCY--VSLPSP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKL--------QRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd15088  159 DDLYW----------------FTIYHFILGFAVPLVVITVCYILILHRLargvapgnQSHGSSRTKRVTKMVILIVVVFI 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHHTAmPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15088  223 VCWLPFHVVQLVNLAMNR-PTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-319 6.72e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.82  E-value: 6.72e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVIlVILRNRRLRTVTNYFILNLAVADLLVGLLvIPFSLVSLLLG-RWWFGDALCKLLGFLQS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPgs 200
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 sswpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------------QRNRLAKTKKPFKIIVTI 265
Cdd:cd00637  158 ----------------SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirssssnssRRRRRRRERKVTKTLLIV 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 266 IITFFLCWCPYHTLNLLELHHTaMPGSVFSLGLPLATALAIANSCMNPILYVFM 319
Cdd:cd00637  222 VVVFLLCWLPYFILLLLDVFGP-DPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
41-325 8.09e-41

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 145.19  E-value: 8.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTtLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISC--FNNFSlst 197
Cdd:cd15159   81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCmeYPNFE--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpthsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR--------NRLAKTKKPFKIIVTIIITF 269
Cdd:cd15159  158 ---------------KIKRLPLILLGACVIGFGVPVGIILFCYSQITLKLCRtakenpltEKSGHHKKACNVILLVLLVF 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 270 FLCWCPYHtLNLLE------LHHTAMPG-SVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15159  223 VVCFSPYH-LNIIQfmirklLYQPSCSElKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
46-326 2.47e-40

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 143.84  E-value: 2.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMdYHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15973    6 IYALVCLVGLIGNSMVIfVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAAL-QHWPFGSAMCRTVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstpgsssWP 204
Cdd:cd15973   85 TSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLI---------WP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 205 thsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQ--------RNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15973  156 --------HPAWSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRavalkagwQQRRKSEKKITRMVLMVVTVFVICWMPF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 HTLNLLELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15973  228 YVVQLLNLFLPRLDATVNHASL----ILSYANSCANPILYGFLSDNFRRS 273
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
42-324 3.40e-40

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 143.74  E-value: 3.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15191    2 AIPVLYSIIFILGFLGNSLVVCVfCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRlAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTp 198
Cdd:cd15191   82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQ-ARLVCLLVWVLACLSSLPTFYFRDTYYIEelGVNACIMAFPNEK- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-----NRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15191  160 -YAQW-------------SAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKtkgfgKNKQRRDKVLKMVAAVVLAFLICW 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 274 CPYHTLNLLE------LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15191  226 FPFHVLTFLDalarmgVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFR 282
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
41-325 8.44e-40

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 142.58  E-value: 8.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKmKKTVNMV--WFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15193    1 IYIPILYLIIFFTGLLGNLFVIALMSKR-STTKRLVdtFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscfnnfslstp 198
Cdd:cd15193   80 IAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLIN---------------- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHMVvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP------FKIIVTIIITFFLC 272
Cdd:cd15193  144 ESVCVEDSSSRFFQGISLATL------FLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGrrrrnsLRIVFAIVTAFVLS 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 273 WCPYHTLN----LLELHHTAMPGS---VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15193  218 WLPFNTLKavrlLLELGGGVLPCHttvAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
41-325 3.01e-39

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 141.07  E-value: 3.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIyVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpg 199
Cdd:cd15094   80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSC---------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR--------NRLAKTKKPFKIIVTIIITFFL 271
Cdd:cd15094  150 TIVWPDSSAV-----NGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTvgpknkskEKRRSHRKVTRLVLTVISVYII 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 272 CWCPY--HTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15094  225 CWLPYwaFQVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
41-325 3.24e-39

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 140.82  E-value: 3.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMdYHWVFGTAMCKISNFLL 119
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIyVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL-RHWPFGSLLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTA-NLHGKISCfnNFSLSTP 198
Cdd:cd15970   80 AINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTApNSDGSVAC--NMQMPEP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQ--------RNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd15970  158 -SQRWL-------------AVFVVYTFLMGFLLPVIAICLCYILIIVKMRvvalkagwQQRKRSERKITLMVMMVVTVFV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15970  224 ICWMPFYVVQLVSVFVGQHDATVSQ----LSVILGYANSCANPILYGFLSDNFKR 274
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
41-325 4.86e-39

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 140.63  E-value: 4.86e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATfKMKK-----TVNmVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKI 114
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLA-RVKPgkrrsTTN-VFILNLSIADLFFLLFcVPFQATIYSLP-EWVFGAFMCKF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 115 SNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiscfNNFS 194
Cdd:cd15098   78 VHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTA----SNQT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 LSTPgssSWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIV---CKLQRNRLAK----TKKPFKIIVTIII 267
Cdd:cd15098  154 FCWE---NWPEKQQ--------KPVYVVCTFVFGYLLPLLLITFCYAKVLnhlHKKLKNMSKKsersKKKTAQTVLVVVV 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 268 TFFLCWCPYHTLNL-LELHHTAMPGSVFSLGLpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15098  223 VFGISWLPHHIIHLwVEFGDFPLTQASFVLRI-TAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
44-322 5.08e-39

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 140.31  E-value: 5.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLIHN 122
Cdd:cd14975    4 CTLLSLAFAIGLPGNSFVIWSILIKVKQrSVTMLLVLNLALADLAVLLTLPVWIYFLATG-TWDFGLAACKGCVYVCAVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnfslstpgsss 202
Cdd:cd14975   83 MYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCK------------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpthsqmdPVGYSRHMVVTVTRF--LCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd14975  151 --------YRHYSDGQLVFHLLLetVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGN 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 281 LLEL--------HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQD 322
Cdd:cd14975  223 LLEVvseliggsKMAGTLGKVAEAGRPIAGALAFLSSSINPLLYAFAARG 272
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
41-325 6.80e-39

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 140.33  E-value: 6.80e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII----ATFKMKKTVNMVWFlNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISN 116
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYLlksnKKLRQQSESNKFVF-NLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF-RDTANLHGKISCfnnfSL 195
Cdd:cd14976   80 YVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFsTDTWSSVNHTLC----LL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPThsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK---KPFKIIVTIIITFFLC 272
Cdd:cd14976  156 RFPKNSSVTR-------WYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRrksRVTKSVFIVVLSFFIC 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 273 WCPYHTLNL-------LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14976  229 WLPNQALSLwsalikfDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRD 288
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
45-324 1.53e-38

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 139.08  E-value: 1.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIII--ATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15157    5 TVYLIIFVLGVVGNGLSIYVflQPSKKKTSVN-IFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPsLVFRDTANLHGKISCFNnfslstpgsss 202
Cdd:cd15157   84 MYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSP-LLSKGTSKYNSQTKCLD----------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wPTHSQMDPVGYSRHMVVTVtrflcGFLVPVLIITACYLTIVCKL------QRNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15157  152 -LHPSKIDKLLILNYIVLVV-----GFILPFCTLSICYILIIKALlkprvpQSKLRVSHKKALLTIIITLILFLLCFLPY 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 HTLNLLELHHTAMPGSVFSL--GLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15157  226 HILRTVHLMQWSEGQCNLRLhkAVVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
41-325 1.97e-38

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 138.75  E-value: 1.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIAT-FKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLL 119
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGyQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN--WYFGNFLCKAVHVIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTpg 199
Cdd:cd15179   79 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDT-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMdpvgysRHMVVtvtrflcGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH-- 277
Cdd:cd15179  157 FELWVVAFRF------QHILV-------GLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYig 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 278 ----TLNLLEL-HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15179  224 isidTFMLLEIiKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
41-325 6.34e-38

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 137.28  E-value: 6.34e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMdYHWVFGTAMCKISNFLL 119
Cdd:cd15971    1 AFLTFIYFVVCIIGLCGNTLVIyVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVAL-VHWPFGKAICRVVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpg 199
Cdd:cd15971   80 GINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSC---------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYsrhMVVTvtrFLCGFLVPVLIITACYLTIVCKLQRN--------RLAKTKKPFKIIVTIIITFFL 271
Cdd:cd15971  150 TIIWPGESSAWYTGF---IIYT---FILGFFVPLTIICLCYLFIIIKVKSSgirvgsskRKKSEKKVTRMVSIVVAVFVF 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15971  224 CWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
41-325 1.52e-36

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 134.26  E-value: 1.52e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAvVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYR-PWVFGEVLCKAVPYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPvWSQNHRSVRLAYMACMV-IWVLAFFLSSPSLVFRdtaNLHGKISCFNNFSLST 197
Cdd:cd14993   80 QGVSVSASVLTLVAISIDRYLAICYP-LKARRVSTKRRARIIIVaIWVIAIIIMLPLLVVY---ELEEIISSEPGTITIY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPthSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKL----------------QRNRLAKTKKPFKI 261
Cdd:cd14993  156 ICTEDWP--SPELRKAY------NVALFVVLYVLPLLIISVAYSLIGRRLwrrkppgdrgsanstsSRRILRSKKKVARM 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 262 IVTIIITFFLCWCPYHTLNLLELHH---TAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14993  228 LIVVVVLFALSWLPYYVLSILLDFGplsSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRR 294
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
41-325 1.32e-35

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 131.57  E-value: 1.32e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYaAMDYHWVFGTAMCKISNFL 118
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYvVLRNKSMQTVTNIFILNLAVSDLLLCLVsLPFTLIY-TLTKNWPFGSILCKLVPSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN--LHGKISCFNNFSLS 196
Cdd:cd15203   80 QGVSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDvpIEILPYCGYFCTES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSwpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITF------- 269
Cdd:cd15203  158 WPSSSS--------------RLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELrrkrrtn 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 270 ----------FLCWCPYHTLNLL-ELHHTAM-PGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15203  224 rlliamvvvfAVCWLPLNLFNLLrDFEPLPQiDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
41-325 1.68e-35

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 131.40  E-value: 1.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNG-LVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15397    1 VFLVVSYSLVMAVGLLGNIcLICVIARQKEKTNVTNILIANLSFSDILVCLVcLPFTVVYTLMD-YWIFGEVLCKMTPFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPV-WSQnhrSVRLAYMACMVIWVLAFFLSSPSLVFRD-TANLHGKISCFNNFSLS 196
Cdd:cd15397   80 QCMSVTVSILSLVLIALERHQLIINPTgWKP---SVSQAYLAVVVIWMLACFISLPFLAFHIlTDEPYKNLSHFFAPLAD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TP-GSSSWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR------------NRLAKTKKPFKIIV 263
Cdd:cd15397  157 KAvCTESWPSEHH--------KLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRrkdmlerrgeynRRAGHSKRINVMLV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 264 TIIITFFLCWCPYHTLN-LLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15397  229 SLVAAFALCWLPLNVFNaIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
41-325 2.59e-35

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 130.31  E-value: 2.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIyVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISY-WPFGSFLCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGkiSCfnnfslstpg 199
Cdd:cd15974   80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLN--TC---------- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPthsqmDPVGYSRHMVVTVTRFLcGFLVPVLIITACYLTIVCKLQRNRL--------AKTKKPFKIIVTIIITFFL 271
Cdd:cd15974  148 NISWP-----EPVSVWSTAFIIYTAVL-GFFGPLLVICLCYLLIVIKVKSSGLrvgstkrrKSERKVTRMVVIIVVVFVF 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15974  222 CWLPFYMLNIVNLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-325 4.58e-35

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 129.89  E-value: 4.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSV 127
Cdd:cd15189    9 SLCLFGLLGNLFVLLVFLLhRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANL--HGKISCFNNFSlstpgSSSWpt 205
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIpdLNITACVLLYP-----HEAW-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 206 hsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK------KPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15189  162 -----------HFAHIVLLNIVGFLLPLLVITFCNYNILQALRTREESTRCedrndsKATALVLAVTLLFLVCWGPYHFF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 280 NLLELHH------TAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15189  231 TFLDFLFdvgvldECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
41-325 5.51e-35

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 130.02  E-value: 5.51e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKM--KKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVLYLMKSKQgwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTP 198
Cdd:cd15926   81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPT--HSQmdpvgysrhmvvtvtRFLCGFLVPVLIITACYLTIVCKLQRNRLA-----KTKKPFKIIVTIIITFFL 271
Cdd:cd15926  161 NAQFWLGlyHAQ---------------KVLLGFLIPLGIISLCYLLLVRFITDKNITgsstkRRSKVTKSVTIVVLSFFL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 272 CWCPYHTL---------NLLELHHTAMPGSVFSlgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15926  226 CWLPNQALttwgiliklNVVHFSYEYFTTQVYI--FPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
41-324 8.78e-35

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 129.22  E-value: 8.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLV--IIIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15092    1 VTIVVVYLIVCVVGLVGNCLVmyVILRHTKMKTATN-IYIFNLALADTLVLLTLPFQGTDIFLGF-WPFGNALCKTVIAI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnFSLSTP 198
Cdd:cd15092   79 DYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECL--VEIPTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWpthsqmDPvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP--------FKIIVTIIITFF 270
Cdd:cd15092  157 -QDYW------DP-------VFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEkdrnlrriTRLVLVVVAVFV 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLElHHTAMPGSVFSLG-LPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15092  223 GCWTPIQIFVLAQ-GLGVQPSSETAVAiLRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
45-325 2.66e-34

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 127.80  E-value: 2.66e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFK--MKKTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNqqMRSTTNIL-ILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanLHGKISCFNnfsLSTPGSSS 202
Cdd:cd15096   84 AYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLF------LHGVVSYGF---SSEAYSYC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpTHSQMDPVGYSrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRL----------AKTKKPFKIIVTIIITFFLC 272
Cdd:cd15096  155 --TFLTEVGTAAQ---TFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSpggrrsaesqRGKRRVTRLVVVVVVVFAIC 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 273 WCPYHtLNLLELHHTAMPGSVFSLGL-PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15096  230 WLPIH-IILLLKYYGVLPETVLYVVIqILSNCLAYGNSCVNPILYAFLSQNFRK 282
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
14-327 6.29e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 128.36  E-value: 6.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  14 YGDEYPDYLDSIVvledlspleARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLP 93
Cdd:PHA03087  23 YDEDYADCDLNIG---------YDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLP 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  94 IHITYAAMDyHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSP 173
Cdd:PHA03087  94 FQIYYYILF-QWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 174 SLVFRDTANLHGKISCFNNFSlstPGSSSWPthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-NRL 252
Cdd:PHA03087 173 ILFVYTTKKDHETLICCMFYN---NKTMNWK-------------LFINFEINIIGMLIPLTILLYCYSKILITLKGiNKS 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 253 AKTKKPFKIIVTIIITFFLCWCPYH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:PHA03087 237 KKNKKAIKLVLIIVILFVIFWLPFNvsvfvySLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKH 316

                 .
gi 215272319 327 K 327
Cdd:PHA03087 317 K 317
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
41-325 8.64e-34

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 126.04  E-value: 8.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd15173    1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKlRTLTDIFLVNLAVADLLFLCTLPFWAYSAA--HEWIFGTVMCKITNGLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAY--MACMVIWVLAFFLSSPSLVFRDTANLHGKIsCFNNFSlst 197
Cdd:cd15173   79 TINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWgkVVCTLVWVISLLLSLPQFIYSEVRNLSSKI-CSMVYP--- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswPTHSQMdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15173  155 ------PDAIEV---------VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYN 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 278 TLNLLE-LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15173  220 IMKLIRtLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
42-325 1.91e-33

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 125.63  E-value: 1.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLLI 120
Cdd:cd15174    2 FLPPLYWLIFLVGAVGNSLVVLIyTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAAS--SGWVFGTFLCKVVNSMYK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAY--MACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstp 198
Cdd:cd15174   80 INFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYskLVCFFVWLLSTILSLPEILFSQSKEEESVTTC--------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPTHSQMdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15174  151 -TMVYPSNESN-----RFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNS 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 279 LNLLELHHtAMPGSVFS--------LGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15174  225 ILLIKTIN-AYNITITDcatsqnldIAGQVTQSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
42-325 2.95e-33

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 124.88  E-value: 2.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIAT-FKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLLI 120
Cdd:cd15175    2 FLPAMYSVICFLGLLGNGLVILTYIyFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKAVYCLYK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRS--VRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslsTP 198
Cdd:cd15175   80 MSFFSGMLLLMCISIDRYFAIVQAASAHRHRSraVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC-------SI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15175  153 FTNNKQTLS----------VKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNS 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 279 LNLLELHHTAMPGSV-------FSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15175  223 VMLVSTLSSFKGNTTdcdysknLDFALDVTYSLACFRCCLNPFLYAFIGVKFRN 276
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
41-326 3.05e-33

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 124.91  E-value: 3.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHiTYAAMDyHWVFGTAMCKISNFLL 119
Cdd:cd15187    1 LFLPVLYCLLFVFGLLGNSLVIwVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQ-AYYLLD-QWVFGNAMCKIVSGAY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSlstPG 199
Cdd:cd15187   79 YIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYP---GQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWP--THSQMDpvgysrhmvvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15187  156 GNSWKvfTNFEVN---------------ILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFN 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 278 TLNLLELHHT------AMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15187  221 VVLFLDSLHSlhiidgCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKH 275
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
42-325 3.20e-33

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 124.92  E-value: 3.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMvWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15921    2 FYPTAYILIFILGLTGNSISVyvFLSQYRSQTPVSV-LMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNnfslstpg 199
Cdd:cd15921   81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLE-------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswPTHSQMDPVgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT------KKPFKIIVTIIITFFLCW 273
Cdd:cd15921  153 ----LAHDAVDKL-----LLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGrtrpsrRKACALIIISLGIFLVCF 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 274 CPYHTLNLLELH----HTAMPGSVFSL--GLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15921  224 LPYHIVRTIHLIterqIKESCGYILRVrkAAVITLCLAASNSCFDPLLYFFVGENFRS 281
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
44-323 5.29e-33

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 124.16  E-value: 5.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLIHN 122
Cdd:cd15121    4 IAILSLAFILGFPGNLFVVWSVLCRMKKrSVTCILVLNLALADAAVLLTAPFFLHFLSGG-GWEFGSVVCKLCHYVCGVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRdtANLHGKIscfnNFSLSTPGSSS 202
Cdd:cd15121   83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYR--TVLKKNI----NMKLCIPYHPS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wPTHSQMdpvgysRHMVVTVTrflcGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLL 282
Cdd:cd15121  157 -VGHEAF------QYLFETIT----GFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 283 E----LHHTAMPGSVF---SLGLPLATALAIANSCMNPILYVFMGQDF 323
Cdd:cd15121  226 QvagaLQNQAGNASVLkaaKLARPNVTALAFLSSSVNPVLYAFAGGSL 273
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
49-325 5.72e-33

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 124.49  E-value: 5.72e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSV 127
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLhKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRdtanlhgKISCFNNFSLstpgssswpTHS 207
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFR-------TVMYFPEYNI---------TAC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 208 QMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK------KPFKIIVTIIITFFLCWCPYH---- 277
Cdd:cd15381  153 VLDYPSEGWHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKeiqterKATVLVLAVLLMFFICWLPFHiftf 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 278 --TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15381  233 ldTLHKLGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
41-318 7.37e-33

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 124.20  E-value: 7.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15194    1 GFLPILYCLVFLVGAVGNAILMgaLVFKRGVRRLID-IFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstp 198
Cdd:cd15194   80 ISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYC--------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL------QRNRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15194  151 ----------NEDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLchhyqkSGKHQKKLRKSIKIVFIVVAAFVFS 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 273 WCPYHTLNLLEL------HHTAMPGSVFSLGLPLATALAIANSCMNPILYVF 318
Cdd:cd15194  221 WMPFNLFKALAIasglqvEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYF 272
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
41-326 8.54e-33

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 123.71  E-value: 8.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15373    1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPwNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpg 199
Cdd:cd15373   81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITC---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswptHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT------KKPFKIIVTIIITFFLCW 273
Cdd:cd15373  151 ------HDTSSPELFDQFVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTStnsrskKKSVKMIIIVLAVFILCF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 274 CPYHTLNLLELHHTAMPGSVFSLGL-----PLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15373  225 LPFHVTRTLYYSFRSMDLSCGTLNAinlayKVTRPLASANSCLDPILYFLAGQSFRSN 282
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
46-325 1.46e-32

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 123.32  E-value: 1.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNG--LVIIIATFKmKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15158    6 LYSVITVFGLVGNGfaLYVLIKTYR-QKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnfslSTPGSSSW 203
Cdd:cd15158   85 YCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCF-----EPPQSNQQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PTHSqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK------KPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15158  160 LTKL----------LVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKqqssrkKAIRMIIIVLLAFLVSFMPYH 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 278 TLNLLELH-----------HTAMPGSVFslglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15158  230 IQRTIHLHflsrkdstceeVLYMQKSVV-----ITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
42-325 1.50e-32

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 122.67  E-value: 1.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILaVYRNRRLRTVTNYFIVSLAVADLLVALLvMPFSAVYTLLGY-WPFGPVLCRFWIALD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRdtanlhgkiscfnnfslsTPG 199
Cdd:cd14967   80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGW------------------RDE 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVgysRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd14967  142 TQPSVVDCECEFT---PNKIYVLVSSVISFFIPLLIMIVLYARIFRVARREL-----KAAKTLAIIVGAFLLCWLPFFII 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 280 NLLELHHTamPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14967  214 YLVSAFCP--PDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
41-325 1.99e-32

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 122.92  E-value: 1.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKkTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIyvILRAPKMK-TVTNVFILNLAIADDLFTLVLPINIAEHLLQQ-WPFGELLCKLILSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQN--HRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKISCFnnFSL 195
Cdd:cd15087   79 DHYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVySNELGRKSCV--LSF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPThsqmdpvgySRhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNR-------LAKTKKPFKIIVTIIIT 268
Cdd:cd15087  157 PSPESLWFKA---------SR-----IYTLVLGFAIPVSTICILYTMMLYKLRNMRlnsnakaLDKAKKKVTLMVLVVLA 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 269 FFL-CWCPYHTLNLLELhHTAMPGSVFSLGLPLA-TALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15087  223 VCLfCWTPFHLSTVVAL-TTDLPQTPLVIGISYFiTSLSYANSCLNPFLYAFLDDSFRK 280
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
41-326 2.88e-32

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 122.56  E-value: 2.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd15172    1 VFVPVIYSLICVVGLIGNSLVVITyAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEA--HQWIFGNFSCKLLRGIY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAY--MACMVIWVLAFFLSSPSLVFRDT--ANLHGKISCFNNFSl 195
Cdd:cd15172   79 AINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYskLICAAVWLLAILISLPTFIFSEVydFGLEEQYVCEPKYP- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPThsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCP 275
Cdd:cd15172  158 KNSTAIMWKL-------------LVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVP 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 276 YHTLNLLELHHTAMPGS-----VFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15172  225 YNIVLLIEAINLGEQQScssekAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNY 280
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
41-323 7.22e-32

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 121.42  E-value: 7.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLtRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSlstpg 199
Cdd:cd15968   81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAP----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRN-------RLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15968  156 -----------PALFPHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTlgpaeppAQARRRKSIRTIVTVTLLFALC 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 273 WCPYHTLNLLELHHTAMPG------SVFSLGLPLATALAIANSCMNPILYVFMGQDF 323
Cdd:cd15968  225 FLPFHITRTIYLAVRVTPGvpchvlEAVAACYKITRPLASANSVLNPLLYFLTKKKF 281
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
45-325 8.16e-32

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 121.24  E-value: 8.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMdYHWVFGTAMCKISNFLlIHN 122
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIyVVSRHREMRTVTNYYIVNLAVTDLAFLVCcVPFTAALYAT-PSWVFGDFMCKFVNYM-MQV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFL-LTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT--ANLHG-KISCfnnfslstp 198
Cdd:cd15095   83 TVQATCLtLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLeeGYWYGpQTYC--------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPTHSqmdpvGYSRHMVVTVtrfLCGFLVPVLIITACYLTIVCKL--------------QRNRLAKTKKPFKIIVT 264
Cdd:cd15095  154 -REVWPSKA-----FQKAYMIYTV---LLTYVIPLAIIAVCYGLILRRLwrrsvdgnnqseqlSERALRQKRKVTRMVIV 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 265 IIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLP-LATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15095  225 VVVLFAICWLPNHVLNLWQRFDPNFPETYATYALKiAALCLSYANSAVNPFVYAFMGENFRK 286
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
52-325 8.66e-32

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 121.06  E-value: 8.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  52 FLGILGNGLVIIIATFKMK---KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLIHNMFTSVF 128
Cdd:cd15122   12 LLGLPGNGFIIWSILWKMKargRSVTCILILNLAVADGAVLLLTPFFITFLTRK-TWPFGQAVCKAVYYLCCLSMYASIF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 129 LLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiscfnNFSLSTPGSSSwPTHSQ 208
Cdd:cd15122   91 IIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGM-----NDRICEPCHAS-RGHAI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 209 MDpvgYSRHMVVTvtrflcgFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTA 288
Cdd:cd15122  165 FH---YTFETLVA-------FVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 215272319 289 MPGSVFS-------LGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15122  235 APGEVLEklggaakAARAGATALAFFSSSVNPLLYVFAAGDLIK 278
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
41-325 4.05e-31

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 119.14  E-value: 4.05e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSAsESVTNIYILNLALADELFMLGLPFLAAQNALSY-WPFGSFMCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhGKISCfnnfslstpg 199
Cdd:cd15972   80 AINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPG--GMGTC---------- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYsrhMVVTVTrflCGFLVPVLIITACYLTIVCKL----QRNRLAKTK------KPFKIIVTIIITF 269
Cdd:cd15972  148 HIAWPEPAQVWRAGF---IIYTAT---LGFFCPLLVICLCYLLIVVKVrssgRRVRATSTKrrgserKVTRMVVIVVAAF 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 270 FLCWCPYHTLNLLELHHT-AMPGSVFSLgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15972  222 VLCWLPFYALNIVNLVCPlPEEPSLFGL-YFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
42-324 1.09e-30

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 117.93  E-value: 1.09e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15372    2 LVPSLYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLstpg 199
Cdd:cd15372   82 NMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLErlNITLCHDVLPL---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsQMDpVGYSRHMVVTVtrFLCGFLVPVLIITACYLTIVCKLQRNRlAKTKKPFKIIVTIIITFFLCWCPYHTl 279
Cdd:cd15372  158 --------DEQ-DTYLFYYFACL--AVLGFLLPLVVILFCYGSVLHTLLRSG-QRYGHAMKLTVLVLVSFVLCFTPSNL- 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 280 nLLELHHTAMPGSVFS-LGLPLATALAIA--NSCMNPILYVFMGQDFK 324
Cdd:cd15372  225 -LLLLHYSDPTLDDGGnLYIVYMVSLAIStlNSCVDPFIYYYVSEEFR 271
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
41-325 1.39e-30

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 117.99  E-value: 1.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15339    1 VILPSFIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCfnNFSLSTPG 199
Cdd:cd15339   81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRdGLESC--AFNLTSPD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsqmdpvgYSRHMVVTvtrflcGFLVPVLIITACYLTIVC----KLQRNRLAK---TKKP-------FKIIVTI 265
Cdd:cd15339  159 DVLW----------YTLYQTIT------TFFFPLPLILICYILILCytweMYRKNKKAGrynTSIPrqrvmrlTKMVLVL 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 266 IITFFLCWCPYHTLNLLELhHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15339  223 VGVFLVSAAPYHVIQLVNL-SVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
41-325 1.52e-30

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 117.87  E-value: 1.52e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVlAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV--HGWIFGTGLCKLAGAVF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF----RDTANLhgKISCFNNFSL 195
Cdd:cd15180   79 KINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFleatKDPRQN--KTECVHNFPQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STpgsSSWPTHSQMDPvgysrHMVvtvtrflcGFLVPVLIITACYLTIVCKLQRNRLAKTK-KPFKIIVTIIITFFLCWC 274
Cdd:cd15180  157 SD---TYWWLALRLLY-----HIV--------GFLLPLAVMVYCYTSILLRLLRSSQGFQKqRAIRVIVAVVVVFFLCWT 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 275 PYH------TLNLLELHHTAMP-GSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15180  221 PYNiallvdTLIDLSVLDRNCGtESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRR 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
41-324 2.16e-30

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 117.15  E-value: 2.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLL 119
Cdd:cd15176    1 LFLPVFYTIALVVGLAGNSLVVAIyAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVlLPVWSQNhRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNF--SLST 197
Cdd:cd15176   79 TMNFSCGMQFLACISVDRYVAI-TKATSRQ-FTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFppSLVT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSwpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15176  157 SAKAT-----------------IQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYN 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 278 TLNL--------LELHHTAMpGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15176  220 VVKFyraidviyLLITDCSM-SKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
41-324 2.26e-30

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 117.16  E-value: 2.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLL 119
Cdd:cd15181    1 VFIPLAYSLVFLLGVVGNGLVLtILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISC-FNNFslS 196
Cdd:cd15181   79 KLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTnaNRTSCsFHQY--G 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSWPThsqmdpvgysrhmvvtvTRFL---CGFLVPVLIITACYLTIVCKL-QRNRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15181  157 IHESNWWLT-----------------SRFLyhvVGFFLPLLIMGYCYATIVVTLcQSSRRLQKQKAIRVAILVTLVFCLC 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 273 WCPYHT---LNLLELHHTAMPGSVFSLGLPLA----TALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15181  220 WLPYNIvifLDTLDDLKAVVKNCKLNDLLDAAitvtESLGFSHCCLNPILYAFIGVKFR 278
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
41-325 2.81e-30

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 116.98  E-value: 2.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLV--IIIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVmfVIIRYTKMKTATN-IYIFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVISI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTP 198
Cdd:cd15091   79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPThsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRL--------AKTKKPFKIIVTIIITFF 270
Cdd:cd15091  159 DYSWWDT-------------FMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLlsgsrekdRNLRRITRLVLVVVAVFV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 271 LCWCPYHTLNLLEL-----HHTAMPGSVFslglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15091  226 VCWTPIHIFILVEAlgsvsHSTAAVSSYY-----FCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
41-324 5.05e-30

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 116.63  E-value: 5.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIwIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscfnnFSLSTPG 199
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIWLASFLLALPQLLYSTT------------ETYYYYT 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSRHM-------VVTVTRFLcgflvPVLIITACYLTIVCKL------------QRNRLAKTKKPFK 260
Cdd:cd15390  147 GSERTVCFIAWPDGPNSLQdfvynivLFVVTYFL-----PLIIMAVAYTRVGVELwgsktigentprQLESVRAKRKVVK 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 261 IIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFK 324
Cdd:cd15390  222 MMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIYLAIYwLAMSNSMYNPIIYCWMNKRFR 286
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
44-324 6.58e-30

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 115.84  E-value: 6.58e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIhITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFvVARFRRMRSVTNVFLASLATADLLLLVFcVPL-KTAEYFSPTWSLGAFLCKAVAYLQLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhGKISCFNNFSLSTPGSS 201
Cdd:cd15001   82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLF--------GQGLVRYESENGVTVYH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPThsqMDPVGYSRHMVVTVtrFLCGFLVPVLIITACYLtivcklqrnrLAKTKKPFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15001  154 CQKA---WPSTLYSRLYVVYL--AIVIFFIPLIVMTFAYA----------RDTRKQVIKMLISVVVLFAVCWGPLLIDNL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 282 L---ELHHTAMPGSVFSLGLPLaTALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15001  219 LvsfDVISTLHTQALKYMRIAF-HLLSYANSCINPIIYAFMSKNFR 263
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
41-324 6.72e-30

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 115.96  E-value: 6.72e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKsGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpg 199
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVC---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthSQMDPVGYSRHMVVTVTrflCGFLVPVLIITACYLTIVCKLQR-NRLAK--TKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15161  151 -------LQLYREKASRGALVSLA---VAFTIPFVTTVTCYLLIIRSLRTgKREEKplKDKAIKMIILVLTIFLICFVPY 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 277 HTLNLLE-LHHTAMPGS-----VFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15161  221 HISRYIYiLSHNGAGAScssrrGLALANRITSCLTCLNGALDPVMYFFVAEKFR 274
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
41-325 7.36e-30

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 115.86  E-value: 7.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMyVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGNILCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSlstpg 199
Cdd:cd15090   80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFS----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmDPVGYSRHMvVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP--------FKIIVTIIITFFL 271
Cdd:cd15090  155 ----------HPSWYWENL-LKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15090  224 CWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
42-325 8.83e-30

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 115.56  E-value: 8.83e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15375    2 YLPVMYSIIFIVGFPGNIIAIFVYLFKMRPwKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnNFSLSTPGS 200
Cdd:cd15375   82 FNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICL-DFTSSDNLN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPthsqmdpvgYSrhMVVTVTrflcGFLVPVLIITACYLTIVCKLQR---NRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15375  161 TIWW---------YN--WILTVL----GFLLPLVIVTLCYTRIIYTLAKgphTGSASKQKARRLIILILLVFYVCFLPFH 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 278 TLNLLELHHTAMPGSVFSLGLPLA-----TALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15375  226 ILRVVRIETRLPPVSCCLKHQVHAiyiitRPLAALNTFGNLLLYVVSGDNFQQ 278
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
42-334 5.93e-29

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 116.27  E-value: 5.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIhITYAAMDyHWVFGTAMCKISNFLLIH 121
Cdd:PHA02638 100 YIKIFYIIIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFPF-IIYNEFD-QWIFGDFMCKVISASYYI 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLhgkISCFNNfslSTPGSS 201
Cdd:PHA02638 178 GFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNI---IFSAQD---SNETIS 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDPVGYSRHMVVTVTRF---LCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPyht 278
Cdd:PHA02638 252 NYQCTLIEDNEKNNISFLGRILQFeinILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIP--- 328
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 279 LNLLELHHTAMPGSVFS--------------LGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRL 334
Cdd:PHA02638 329 LNIVILFATMYSFKGFNsiisehicgfiklgYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRNI 398
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
41-325 9.21e-29

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 113.10  E-value: 9.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPI----HITYAamdyhWVFGTAMCKI 114
Cdd:cd15207    1 VLFIVSYSLIFLLCVVGNVLVClVVAKNPRMRTVTNYFILNLAVSDLLVGVFcMPFtlvdNILTG-----WPFGDVMCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 115 SNFLLIHNMFTSVFLLTIISSDRCISVLLPvwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdtanLHGKISCFNNFS 194
Cdd:cd15207   76 SPLVQGVSVAASVFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPQALV-----LEVKEYQFFRGQ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 LSTPGSSSWPThsqmdpVGYSRhmVVTVTRFLCGFLVPVLIITACYLTIVCKL---------------QRNRLAKTKKPF 259
Cdd:cd15207  149 TVHICVEFWPS------DEYRK--AYTTSLFVLCYVAPLLIIAVLYVRIGYRLwfkpvpgggsasreaQAAVSKKKVRVI 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLLE-LHHTAMPGS--VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15207  221 KMLIVVVVLFALSWLPLHTVTMLDdFGNLSPNQRevLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
45-325 1.74e-28

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 112.17  E-value: 1.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI--IIATFKMKKTVNMvWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIH 121
Cdd:cd14971    5 LFFALIFLLGLVGNSLVIlvVARNKPMRSTTNL-FILNLAVADLTFLLFcVPFTATIYPLP-GWVFGDFMCKFVHYFQQV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanLHGkiscfnnfsLSTPGSS 201
Cdd:cd14971   83 SMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA------LHR---------LRNYTPG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDPVGYSRHMVVTVTrFLCGFLVPVLIITACYLTIVCKL----------QRNRLAKtKKPFKIIVTIIITFFL 271
Cdd:cd14971  148 NRTVCSEAWPSRAHRRAFALCT-FLFGYLLPLLLICVCYAAMLRHLwrvavrpvlsEGSRRAK-RKVTRLVLVVVVLFAA 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 272 CWCPYHTLNLLELHHTAmPGSVFSLGLP-LATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14971  226 CWGPIHAILLLVALGPF-PLTYATYALRiWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
41-325 1.89e-28

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 111.97  E-value: 1.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15089    1 IAITALYSVVCVVGLLGNVLVMygIVRYTKMKTATN-IYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCFNNFSlst 197
Cdd:cd15089   79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRdGAVVCMLQFP--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpthsqmDPVGYsRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP--------FKIIVTIIITF 269
Cdd:cd15089  156 ------------SPSWY-WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEkdrnlrriTRMVLVVVAAF 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 270 FLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15089  223 IICWTPIHIFVIVwTLVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
41-324 3.54e-28

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 111.32  E-value: 3.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15160    1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKeNVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSL----VFRDTANlhgKISCFNNFsl 195
Cdd:cd15160   81 YTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLghdeLFRDEPN---HTLCYEKY-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 stpgssswpthsQMDpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNR--LAKTKKPFKIIVTIIITFFL-C 272
Cdd:cd15160  156 ------------PME----GWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPslEREEKRKIIGLLLSIVVIFLlC 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 273 WCPYHTLNL----LELHHTAM--------PGSVFSLGLplaTALaiaNSCMNPILYVFMGQDFK 324
Cdd:cd15160  220 FLPYHVVLLvrsvIELVQNGLcgfekrvfTAYQISLCL---TSL---NCVADPILYIFVTEDVR 277
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
41-324 3.74e-28

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 111.39  E-value: 3.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd16001    1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRwTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNnfsLSTPG 199
Cdd:cd16001   81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYD---LTSPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SsswptHSQMDPVGysrhMVVTVTrflcGFLVPVLIITACYLTIVCKLQRNR------LAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd16001  158 N-----FGNYFPYG----MVLTVT----GFLIPFLIILLCYCLMIKSLIRSEeaagvgKAARAKSIRTILLVCGLFALCF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 274 CPYH---TLNLLELHHTAMPGSVF---SLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd16001  225 VPFHitrTIYLFVRVYLVQDCPLLqfvSLAYKIWRPLVSFNSCINPLLYFLSGDSNR 281
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
50-324 4.42e-28

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 111.43  E-value: 4.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  50 VCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVF 128
Cdd:cd15380   10 ICFFGLLGNLFVLFVfLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 129 LLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRdtanlhgKISCFNNFSLSTpGSSSWPTHSQ 208
Cdd:cd15380   90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFR-------SVKHVPDLNISA-CILLFPHEAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 209 mdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK--------KPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15380  162 --------HFARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKrcgglkdtKATRLILTLVLMFLVCWTPYHFFA 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 281 LLE--LHHTAMPGSVF----SLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15380  234 FLDflFQVEVIQGCFWeefiDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
41-325 5.42e-28

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 111.12  E-value: 5.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK--TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLRNCARRapPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSlstp 198
Cdd:cd15925   81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFP---- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPTHSQMDpvgysrhmvvtvtRFLCGFLVPVLIITACYLTIVCKLQR-----NRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15925  157 -SNYWLGAYHLQ-------------RVVVAFVVPLGVITTSYLLLLSFLQQhkvnqNNRQRQSVIARSVRLVVASFFLCW 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 274 CPYHTLNL--LELHHTAMPGS-----VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15925  223 FPNHVVTFwgVLVKFRAVPWNstfyfIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
41-326 8.06e-28

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 110.26  E-value: 8.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGL--VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFL 118
Cdd:cd15188    1 VFLPVFYTLVFLLGLAGNLLlfVVLLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVA--WHWVFGSFLCKFVSTL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCFNNFSLSt 197
Cdd:cd15188   79 YTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNnGVWVCHADYGGH- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgSSSWpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY- 276
Cdd:cd15188  158 --HTIW-------------KLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYn 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 277 -----HTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15188  223 ltlflHSLQDLHVIGNCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLY 277
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-326 1.09e-27

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 110.06  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYS-IVCFLGIlGNgLVIIIATFKMKKTVNMVWFL--NLAVADFLFNVF-LPIhityaAMDYH------WVFGTA 110
Cdd:cd15204    1 IVLGVVYVlIMLVCGV-GN-LLLIAVLARYKKLRTLTNLLiaNLALSDFLVAVFcLPF-----EMDYYvvrqrsWTHGDV 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 111 MCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRsvRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKIS 188
Cdd:cd15204   74 LCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKR--RTACVVIALVWVVSLLLAIPSAVYSKTTPYAnqGKIF 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 189 CfnnfslstpgSSSWPTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKL------------QRNRLAKTK 256
Cdd:cd15204  152 C----------GQIWPVDQQAYYKAY------YLFLFVLEFVLPVLIMTLCYLRIVRKVwfrrvpgqqteqIRRRLRRRR 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 257 KPFKIIVTIIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGL-PLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15204  216 RKVRLLVVILTAFVLCWAPYYGYAIVrDFFPTLLSKEKLNTTIfYIVEALAMSNSMINTVVYVAFNNNIRKY 287
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
45-324 1.28e-27

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 109.81  E-value: 1.28e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKK---TVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIGILLNNARKgkpSLIDSLILNLSAADLLLLLFsVPFRAAAYSKG-SWPLGWFVCKTADWFGH 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQN--HRSVrLAYMACmvIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstp 198
Cdd:cd15002   83 ACMAAKSFTIAVLAKACYMYVVNPTKQVTikQRRI-TAVVAS--IWVPACLLPLPQWLFRTVKQSEGVYLCILCI----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssSWPTHSQMdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRL--------AKTKKPFKIIVTIIITFF 270
Cdd:cd15002  155 ---PPLAHEFM--------SAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTktqnlrnqIRSRKLTHMLLSVVLAFT 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15002  224 ILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
41-325 1.60e-27

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 109.47  E-value: 1.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKpKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLST 197
Cdd:cd15368   81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKelNITTCFDVLKWTM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 -PGSSSWpthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFL----C 272
Cdd:cd15368  161 lPNIAAW--------------AAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRAIYLALIVLLvfitC 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 273 WCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15368  227 FAPNNFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRK 279
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
41-324 2.62e-27

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 108.60  E-value: 2.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVFLPihitYAAMDYH--WVFGTAMCKISNF 117
Cdd:cd15182    1 AFLPVFYYLVFLLSLLGNGLVlWILVKYEKLKTLTNIFILNLAISDLLFTFTLP----FWASYHSsgWIFGEILCKAVTS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKISCfnnfsls 196
Cdd:cd15182   77 IFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVmKSDEDGSLC------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgssswpthsqmDPVGYSRHMVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15182  150 -------------EYSSIKWKLGYYYQQNLF-FLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPY 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 277 HTLNLLELHH-TAMPGSVFSLGLPLA----TALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15182  216 NIVIFLRSLKdLTIPICECSKQLDYAfyicRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
41-324 6.90e-27

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 107.92  E-value: 6.90e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKkKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNnfslst 197
Cdd:cd15162   81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPalDITTCHD------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpTHSQMDPVGYSRHMVVTVtrFLCGFLVPVLIITACYLTIVCKL----QRNRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15162  155 -------VLPEQLLVGDWFYYFLSL--AIVGFLIPFILTASCYVATIRTLaaleDENSEKKKKRAIKLAATVLAIFIICF 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 274 CPYhtlNLLELHHTAMP-----GSVFSLGLPlATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15162  226 APS---NLLLLAHYSLIsssgtGHLYFAYLL-ALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
45-325 9.66e-27

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 107.60  E-value: 9.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLV--IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIH 121
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVlaVLLRSGQSGHNTTNLFILNLSVADLCFILFcVPFQATIYSLE-GWVFGSFLCKAVHFFIYL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscFNNFSLSTPGSS 201
Cdd:cd15097   84 TMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLID-------YANSTVCMPGWE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWpthsqmdpvgysRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR---------NRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15097  157 EA------------RRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTavdpleamsESKRAKRKVTKMIIIVTALFCLC 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 273 WCPYHTLNLLELH-HTAMPGSVFSLGLpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15097  225 WLPHHVVILCYLYgDFPFNQATYAFRL-LSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-326 1.47e-26

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 107.14  E-value: 1.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHI-TYAAMDyhWVFGTAMCKISNFLL 119
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMyVYILNLALADLLYLLTIPFYVsTYFLKK--WYFGDVGCRLLFSLD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPG 199
Cdd:cd14999   79 FLTMHASIFTLTVMSTERYLAVVKPL-DTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdPVGYSRHMVVTvtrFLCGFLVPVLIITACYLTIVCKL----------QRNRLAKtKKPFKIIVTIIITF 269
Cdd:cd14999  158 -----------EESYKVYLTLL---FSTSIVIPGLVIGYLYIRLARKYwlsqaaasnsSRKRLPK-QKVLKMIFTIVLVF 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 270 FLCWCPYHTLNLLELHHTAMPGSVFSLGLP--LATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd14999  223 WACFLPFWIWQLLYLYSPSLSLSPRTTTYVnyLLTCLTYSNSCINPFLYTLLTKNYKEY 281
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
41-326 2.40e-26

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 106.07  E-value: 2.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMdyHWVFGTAMCKISNFLL 119
Cdd:cd15186    1 IFLSIFYSLVFAFGLVGNLLVVLaLTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLIN--EWGLHNAMCKLTTAFF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF-RDTANlhgkiSCFNNFSLSTp 198
Cdd:cd15186   79 FIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFtKMKEN-----ECLGDYPEVL- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH- 277
Cdd:cd15186  153 -QEIWP-------------VLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNv 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 278 -----TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15186  219 mifleTLKLYDFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRY 272
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
42-326 2.56e-26

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 106.38  E-value: 2.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLLI 120
Cdd:cd15184    2 LLPPLYSLVFIFGFVGNMLVVLIlINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNAMCKLLTGLYH 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpgS 200
Cdd:cd15184   80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTC----------S 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPtHSQMDpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK-KPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15184  150 PHFP-PSQYQ----FWKNFQTLKMNILGLVLPLLVMIICYSGILKTLLRCRNEKKRhKAVRLIFTIMIVYFLFWAPYNIV 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 280 NLLELHHTAM------PGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15184  225 LLLNTFQEFFglnncsSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSY 277
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
41-325 6.28e-26

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 105.28  E-value: 6.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII----ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISN 116
Cdd:cd15338    1 VIMPSVFGVICFLGIIGNSIVIYTivkkSKFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH-GKISCfnNFSL 195
Cdd:cd15338   81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPdGSVGC--ALLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKL--------QRNRLAKTKKPFKIIVTIII 267
Cdd:cd15338  159 PNPETDTY---------------WFTLYQFFLAFALPLVVICVVYFKILQNMastvaplpQRSLRVRTKKVTRMAVAICL 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 268 TFFLCWCPYHTLNLLELhHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15338  224 AFFICWAPFYILQLAHL-SIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKR 280
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
49-342 7.75e-26

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 104.64  E-value: 7.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWvFGTAMCKISNFLLIHNMFTSVF 128
Cdd:cd14973    9 LLSLCGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMFFSYTVGLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 129 LLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdtanlhgkiscfnnfslstPGSSSWPTHsq 208
Cdd:cd14973   88 LLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYF--------------------CGFLFWKFN-- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 209 mdPVGYSRHMVVTVTRFLcgFLVPVLIItaCYLTIVCKLQRN-RLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHT 287
Cdd:cd14973  146 --ESACRTFNFLSALLFL--LLFLVMCV--SSLTLLIRVQCSsQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFS 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 288 AMPGSVFslgLPLATALAIANSCMNPILYVFMG-QDFKKFKVALFSRLVNALSEDT 342
Cdd:cd14973  220 NYLFHTF---HPISDLLSCVNSSANPIIYFFVGsLRGRRLREPLRVVLQRALRDEP 272
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
42-316 8.49e-26

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 104.78  E-value: 8.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVN--MVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15376    2 FLWPILGVEFLVAVLGNGLALWLFVTRERRPWHtgVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKISCfnnfsLSTP 198
Cdd:cd15376   82 TCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLeVERHNKTEC-----LGTA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHsqmdpVGYSRHMVVtvtrFLCGflVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWC---P 275
Cdd:cd15376  157 VDSRLPTY-----LPYSLFLAV----VGCG--LPFLLTLASYLAIVWAVLRSPGITTLEKRKVAALVAVVVALYAVsfvP 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 276 YHTLNLLELH------HTAMPGSVFSlGLPLATALAIANSCMNPILY 316
Cdd:cd15376  226 YHILRNLNLYrrlqwlKAAASLRIYF-AYQVTKGLVTLNMCIHPLLY 271
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
42-326 2.59e-25

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 103.37  E-value: 2.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIAT-FKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15185    2 FLPPLYSLVFIVGLLGNVVVVVILIkYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWN-NWVFGHGMCKLLSGFYY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpgS 200
Cdd:cd15185   81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLC----------S 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDpvgYSRHMVVTVTRFlcGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15185  151 PLYPEDTEDS---WKRFHALRMNIF--GLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 281 LLELHHTAMPGSV------FSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15185  226 LLSAFQSIFFETDcerskhLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKY 277
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
43-326 4.43e-25

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 103.03  E-value: 4.43e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLIH 121
Cdd:cd15183    3 LPPLYSLVFIIGVVGNVLVVLVlIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKD-DWIFGDAMCKFLSGFYYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpgSS 201
Cdd:cd15183   82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTC----------SA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDpvgYSRHMVVTVTrfLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15183  152 HFPRKSLIR---WKRFQALKLN--LLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAF 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 282 LE------LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15183  227 VSafqdvlFTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKY 277
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
41-325 7.61e-25

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 102.28  E-value: 7.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVfLKKKKLRTPLNLFLLNLALADLLMSVVgYPLSFYSNLSGR-WSFGDPGCVIYGFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF-----RDTanlhGKISCFNNF 193
Cdd:cd14969   80 VTFLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWALPPLFGwssyvPEG----GGTSCSVDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 SLSTPGSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQR-----------NRLAKTKKP---- 258
Cdd:cd14969  155 YSKDPNSLSY-----------------IVSLFVFCFFLPLAIIIFCYYKIYRTLRKmskraarrknsAITKRTKKAekkv 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 259 FKIIVTIIITFFLCWCPYHTLNLLElhhTAMPGSVFSLGLPLATAL-AIANSCMNPILYVFMGQDFKK 325
Cdd:cd14969  218 AKMVLVMIVAFLIAWTPYAVVSLYV---SFGGESTIPPLLATIPALfAKSSTIYNPIIYVFMNKQFRR 282
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
41-325 1.15e-24

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 101.78  E-value: 1.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIAT-FKMKKTVNMVWFLNLAVADFLFNVFLPIHItyAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15177    1 VFQPCVYLVVFVLGLVGNGLVLATHTrYRRLRSMTDVYLLNLALADLLLLLTLPFAA--AETLQGWIFGNAMCKLIQGLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVL--LPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLST 197
Cdd:cd15177   79 AINFYSGFLFLTCISVDRYVVIVraTSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHsqmdpvgysrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15177  159 SRTVKGATA---------------LTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYS 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 278 TLNLLE----LHHTAMPGSVFS---LGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15177  224 VVLLLDtadlLATLELSCSQSKrkdIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
49-326 1.68e-24

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 101.28  E-value: 1.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSV 127
Cdd:cd15201    9 LEFVLGLLGNGLALWIFCFHLKSwKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVL-----AFFLSSPSLVFRDTANlhgkiSCfNNFSLSTPGSSS 202
Cdd:cd15201   89 FFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLtiamtVYLLTKKHLFPRGNAT-----QC-ESFNICTGTDSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 WPTHSQMdpvgysrhmvvtvtrFLCGFLVPVLIITACYLTIVCKLQRNRL---AKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15201  163 SNWHEAM---------------FLLEFFLPLAIILYCSVRIIWQLRGRQLdrhAKIKRAVQFIMVVAIVFIICFLPSNVT 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 280 NLLELHHTAMPGSVFSLGLPLATALAIA------NSCMNPILYVFMGQDFKKF 326
Cdd:cd15201  228 RIAIWILKHTSNEDCQYYRSVDLAFYITisftyfNSMLDPVVYYFSSPSFKNF 280
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
45-325 2.21e-24

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 101.15  E-value: 2.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAaMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKmRNETAIFMTNLAVSDLLFVFTLPFKIFYN-FNRHWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTpgsssW 203
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSI-----W 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PTHSQMdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRL-----AKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15155  159 KTYLSK----------ITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATlsqigTNKEKVLKMILVHVAIFVVCFVPYNS 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 279 lnLLELHHTAMPGSVFSLGL--------PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15155  229 --ILFLYALVRSQAIANCGVerfartmyPITLCLATLNCCFDPFVYYFTSESFQK 281
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
42-324 2.36e-23

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 98.22  E-value: 2.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15967    2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNInVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhGKISCFNnfSLSTPGS 200
Cdd:cd15967   82 LNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNS--NGTKCFD--TTFNDYL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSqmdpvgysrhMVVTVTrflcGFLVPVLIITACYLTIVCKLQRNRLAKT---KKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15967  158 ESYLTYS----------LGWTVT----GFVIPLLIILGCYGHVVVVLCRNNNVDKglkQRCLKLVIILIVLFSVCYIPYH 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 278 TLNLLELHH---------TAMPGSVFsLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15967  224 VFRNLNLLSrilqkqgscTQWFRGIY-IAHQVSRGLVCLNSALNPLVYLMGSEDIL 278
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
42-326 2.43e-23

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 97.90  E-value: 2.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd14991    2 ILPPLLILEFVLGLPGNVVALWIFCFHSRtWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfNNFSLSTPGS 200
Cdd:cd14991   82 VNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSC-HSFSSYTKPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMdpvgysrhmvvtvtrFLCGFLVPVLIITACYLTIVCKLQR----NRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd14991  161 LSIRWHNAL---------------FLLEFFLPLGLIVFCSVRIACNLRIrqslGKQARVQRAIRLVFLVVIVFVLCFLPS 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 277 HTLNLLeLHHTAMPGSVFSLG-----LPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd14991  226 IIAGLL-ALVFKNLGSCRCLNsvaqlFHISLAFTYLNSALDPVIYCFSSPWFRNS 279
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
44-318 3.32e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 97.83  E-value: 3.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWF-LNLAVADFLFNVF--LPiHITYAAMdYHWVFGTAMCKISNFLLI 120
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFiLNLAIADLVVAFFtvLT-QIIWEAT-GEWVAGDVLCRIVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRsvRLAYMACMVIWVLAFFLSSPSL-VFRDTANLHGKISCFnnfslstpg 199
Cdd:cd14986   82 VGLFASTYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVLSFLFSIPQLvIFVERELGDGVHQCW--------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 sSSWPTHSQMDPvgYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLAKT------------------------ 255
Cdd:cd14986  151 -SSFYTPWQRKV--YITWLATYV------FVIPLIILSYCYGRILRTIWIRSRQKTdrpiaptamscrsvscvssrvsli 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 256 ----KKPFKIIVTIIITFFLCWCPYHTLNLLELH--HTAMPGSVFSlglpLATALAIANSCMNPILYVF 318
Cdd:cd14986  222 srakIKTIKMTLVIILAFILCWTPYFIVQLLDVYagMQQLENDAYV----VSETLASLNSALNPLIYGF 286
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
46-318 4.99e-23

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 97.23  E-value: 4.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKvRNETTTYMINLAISDLLFVFTLPFRIFYFVQR-NWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANL--HGKISCFNNFSlstpgSSS 202
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQlnNNSETCFENFS-----SKT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 WPTHsqmdpvgYSRHMVVTVTrflCGFLVPVLIITAC------YLTIVCKLQRNRLAKtKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15156  160 WKTY-------LSKIVIFIEI---VGFFIPLILNVTCstmvlkTLRRPNTLSRSKLNK-KKVLKMIFVHLFIFCFCFIPY 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 277 H-TLNLLELHHT-----AMPGSVFSLGLPLATALAIANSCMNPILYVF 318
Cdd:cd15156  229 NvNLVLYSLVRTqtfknCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
42-318 6.03e-23

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 97.14  E-value: 6.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15369    2 FVPSVYTIVFVISLPLNILALVVFLRKMRvKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLStp 198
Cdd:cd15369   82 CNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPdlGITTCHDVLNEQ-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmDPVGYSRHMVVTVTRFLcgFLVPVLIITACYLTIVCKLQR-----NRLAKTKKPFkIIVTIIITFFLCW 273
Cdd:cd15369  160 -----------LLMGYYVYYFSIFSCLF--FFVPLIITTVCYVSIIRCLSSssdvaNSSKKTRALF-MAVAVFCVFVICF 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 274 CPYHTLNL---LELHHTAMPGSVFSLGLpLATALAIANSCMNPILYVF 318
Cdd:cd15369  226 GPTNVLLLahyVRFAYTSTNDASYFAYL-LCVCVGSISCCLDPLIYYY 272
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
45-321 6.52e-23

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 97.34  E-value: 6.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNG-LVIIIATFKMKKTVNMVWFLNLAVADFLFnvfLPIHITYAAMDY---HWVFGTAMCKISNFLLI 120
Cdd:cd15927    5 ILFALIFLVGVLGNGtLILIFLRNKSMRNVPNIFILSLALGDLLL---LLTCVPFTSTIYtldSWPFGEFLCKLSEFLKD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKIscFNNFSLSTPGS 200
Cdd:cd15927   82 TSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTD--NQTIQICYPYP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWpthsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------QRNRLAKT-----KKPFKIIVTII 266
Cdd:cd15927  160 QEL---------GPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLirstrnigsGQNQAAQRqiearKKVAKTVLAFV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 267 ITFFLCWCPYHTLNLleLHHTAMPGS--------VFSLglpLATALAIANSCMNPI-LYVFMGQ 321
Cdd:cd15927  231 VLFAVCWLPRHVFML--WFHFAPNGLvdynafwhVLKI---VGFCLSFINSCVNPVaLYLLSGS 289
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
42-325 1.87e-22

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 95.75  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15377    2 YLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGIsVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGK-ISCFNNfslstpg 199
Cdd:cd15377   82 VNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKtITCYDT------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpTHSQMDPVGYSRHMVVTVTrflcGFLVPVLIITACYLTIVCKLQRNRLAKT--------KKPFKIIVTIIITFFL 271
Cdd:cd15377  155 -----TSDEYLRSYFIYSMCTTVA----MFCVPFILILGCYGLIVRALIYKDMKYTeennaplrRKSIYLVIIVLTVFAV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 272 CWCPYHTLNLLELH---------HTAMPGSVFSLgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15377  226 SYLPFHVMKTLNLRarldfqtpaMCAFNDRVYAT-YQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
41-325 2.82e-22

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 95.28  E-value: 2.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGN-GLVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNlCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMcIPFTAVYTLMD-HWIFGETMCKLTSFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPV-WSQNhrsVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiSCFNNFSLST 197
Cdd:cd15396   80 QSVSVSVSIFSLVLIAIERYQLIVNPRgWKPS---ASHAYWGIVLIWLFSLMISIPFLIFHQLTD-----EPFRNLSSHS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSS-------SWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTI-VCKLQRN-----------RLAKTKKP 258
Cdd:cd15396  152 DFYKdkvvcieAWPSETE--------RLIFTTSLLVFQYFVPLGFIFICYLKIfVCLKKRNskidrmrenesRLSENKRI 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 259 FKIIVTIIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15396  224 NTMLISIVVTFAACWLPLNIFNVVfDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
44-324 4.25e-22

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 94.73  E-value: 4.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYH-WVFGTAMCKISNFLLIH 121
Cdd:cd15392    4 ILMYSTIFVLAVGGNGLVCyIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQyWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSL----VFRDTANLHGKISCfnnfslst 197
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAitsrLFEDSNASCGQYIC-------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgSSSWPTHSQMDpvgysrhmVVTVTRFLCGFLVP--VLIITACYLTIVCKLQR----------NRLAKTK-KPFKIIVT 264
Cdd:cd15392  154 --TESWPSDTNRY--------IYSLVLMILQYFVPlaVLVFTYTRIGIVVWAKRtpgeaennrdQRMAESKrKLVKMMIT 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 265 IIITFFLCWCPYHTLNLLELHH-TAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15392  224 VVAIFALCWLPLNILNLVGDHDeSIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFR 284
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
47-324 4.58e-22

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 94.47  E-value: 4.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  47 YSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAaMDYHWVFGTAMCKISNFLLIHNMFT 125
Cdd:cd15153    7 YIIIFIPGLLANSAALwVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYY-IQHTWPFGRFLCLLCFYLKYLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 126 SVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGssswpt 205
Cdd:cd15153   86 SICFLTCISIQRCFFLLHPFKARDWKR-RYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLN------ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 206 hsqmdpVGYSRHMVVTVTRFlcGFLVPVLIITACYLTIVCKL-----QRNRLAKTKKPFKIIVTIIITFFLCWCPYHT-- 278
Cdd:cd15153  159 ------FGAAIAMMTVAELF--GFVIPLFIIAWCTWKTENSLrqrnkQQQSTSEKQKALRMVRMCAAVFFICFAPYHInf 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 279 ---LNLLELHHTAMPGSVFSLGL-PLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15153  231 lfyLMVSESIITNCEVSQVILQFhPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
41-325 5.43e-22

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 94.42  E-value: 5.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKISNFL 118
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIaALARHKNLRGATNYFIASLAISDLLMALFcTPFNFTYV-VSLSWEYGHFLCKIVNYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstp 198
Cdd:cd14992   80 RTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIF----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWPTHSQmdpvgYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKL-------------QRNRLAKTKKPFKIIVTI 265
Cdd:cd14992  155 -CCQIPPVDN-----KTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELwfrkvpgfsikevERKRLKCKRRVIKMLVCV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 266 IITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14992  229 VVLFVICWLPFHLFFLLRDFFPLIMKEKHTLQVYYFLHwIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
43-325 6.18e-22

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 94.50  E-value: 6.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGN-GLVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15395    3 LALAYSAVIILGVSGNlALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMcLPFTFVYTLMD-HWVFGEAMCKLNSMVQC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPV-WSQNHRSvrlAYMACMVIWVLAFFLSSPSLVFR--DTANLHGKISCFNNFSLST 197
Cdd:cd15395   82 ISITVSIFSLVLIAIERHQLIINPRgWRPNNRH---AYVGIAVIWVLAVLTSLPFLIFQvlTDEPFKNVNVSLDAYKGKY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRN------------RLAKTKKPFKIIVTI 265
Cdd:cd15395  159 VCLDQFPSDTI--------RLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRnnmmdkmrdnkyRSSETKRINIMLISI 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 266 IITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15395  231 VVAFAVCWLPLNIFNAVfDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
41-324 7.67e-22

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 94.11  E-value: 7.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCwIIFKNQRMRTVTNYFIVNLAVADIMITLFnTPFTFVRAVNNT-WIFGLFMCHFSNFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPslvfrdtanlHGKIScfnnfSLSTP 198
Cdd:cd15202   80 QYCSVHVSAYTLTAIAVDRYQAIMHPL--KPRISKTKAKFIIAVIWTLALAFALP----------HAICS-----KLETF 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHM----VVTVTRFLCGFLVPVLIITACYLTIVCKLQRNR-------------LAKTKKPFKI 261
Cdd:cd15202  143 KYSEDIVRSLCLEDWPERADlfwkYYDLALFILQYFLPLLVISFAYARVGIKLWASNmpgdatteryfalRRKKKKVIKM 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 262 IVTIIITFFLCWCPYHTLNLLeLHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFK 324
Cdd:cd15202  223 LMVVVVLFALCWLPFNIYVLL-LSSKPDYLIKTINAVYFAFHwLAMSSTCYNPFIYCWLNERFR 285
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
41-325 1.01e-21

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 93.71  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPwNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCfnnfslstpg 199
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLC---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswptHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT--------KKPFKIIVTIIITFFL 271
Cdd:cd15374  151 ------HDTTRPEEFDHYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSrqqgpsskKRSLKTIIMVLTVFAI 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGL-----PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15374  225 CFVPFHITRTLYYVARLLKADCDTLNIinvtyKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
43-325 1.18e-21

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 93.22  E-value: 1.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15206    3 IIPLYSVIFLLAVVGNILVIVtLVQNKRMRTVTNVFLLNLAVSDLLLAVFcMPFTLVGQLLR-NFIFGEVMCKLIPYFQA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstpgs 200
Cdd:cd15206   82 VSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCRE------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 sSWPTHsqmdpvGYSRHMVVTVTRFLcgFLVPVLIITACYLTIVCKLqrnRLAKtKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15206  155 -VWPNE------IAEQAWYVFLDLML--LVIPGLVMSVAYGLISWTL---LEAK-KRVIRMLFVIVVEFFICWTPLYVIN 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 281 LLELHHTA-MPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15206  222 TWKAFDPPsAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
43-324 2.04e-21

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 92.90  E-value: 2.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd14987    3 LSFFYIFIFVIGLLANSVVVWVnLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPslvfrDTANLHGKISCFNNfslSTPGSS 201
Cdd:cd14987   83 NLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLP-----DTYFLKTVTSPSNN---ETYCRS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSqmdpvgYSRHMV-VTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd14987  155 FYPEES------FKEWLIgMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVV 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 281 LLE-------LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd14987  229 LLDilsflhlIPFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
45-325 4.97e-21

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 92.01  E-value: 4.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFN-VFLPIhITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIyAFCRFKSLRTPANYLIINLAISDFLMCiLNCPL-MVISSFSGRWIFGKTGCDMYGFSGGLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCfnnfslstpgss 201
Cdd:cd15083   84 GIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGlLTSC------------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQmDPVGYSRHMVVTVTrflcGFLVPVLIITACYLTIV-----CKLQRNRLAKTK----------------KPFK 260
Cdd:cd15083  152 SFDYLSR-DDANRSYVICLLIF----GFVLPLLIIIYCYSFIFravrrHEKAMKEMAKRFskselsspkarrqaevKTAK 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 261 IIVTIIITFFLCWCPYHTLNLLELhhtAMPGSVFS-LGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15083  227 IALLLVLLFCLAWTPYAVVALIGQ---FGYLEVLTpLATAIPAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
41-325 1.17e-20

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 90.93  E-value: 1.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIwVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQnhRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLhgkiscfnnfslstPG 199
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALALRVEEL--------------TD 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSR--HMVVTVTRFLCGFLVPVLIITACYLTIVCKL-------------QRNRLAKTKKPFKIIVT 264
Cdd:cd15393  145 KTNNGVKPFCLPVGPSDdwWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIwgtkapgnaqdvrDDEILKNKKKVIKMLII 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 265 IIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15393  225 VVALFALCWLPLQTYNLLnEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
38-327 1.37e-20

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 90.34  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  38 VTRIFLVVVYSIVCFlgilGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLpihITYAAMDYHW--VFG------ 108
Cdd:cd15137    2 VLRVFIWVVGIIALL----GNLFVLIWrLKYKEENKVHSFLIKNLAIADFLMGVYL---LIIASVDLYYrgVYIkhdeew 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 109 --TAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMVIWVLAFFLSS-PSLVFRDTANLHG 185
Cdd:cd15137   75 rsSWLCTFAGFLATLSSEVSVLILTLITLDRFICIVFPF-SGRRLGLRRAIIVLACIWLIGLLLAVlPLLPWDYFGNFYG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 186 KIS-CFnNFSLSTPGSSSWpthsqmdpvGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVT 264
Cdd:cd15137  154 RSGvCL-PLHITDERPAGW---------EYS------VFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMA 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 265 IIITFFL-------CWCPYHTLNLLELHHTAMPGSVFS----LGLPLatalaiaNSCMNPILYVFMGQDFKKFK 327
Cdd:cd15137  218 VAKRFFLivltdflCWIPIIVIGILALSGVPIPGEVYAwvavFVLPI-------NSALNPILYTLSTPKFRKKL 284
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
41-325 1.67e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 90.09  E-value: 1.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFnVFLPIHITYAA-MDYHWVFGTAMCKISNFL 118
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVChVIFKNKRMHTATNLFIVNLAVSDILI-TLLNTPFTLVRfVNSTWVFGKIMCHLSRFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACmvIWVLAFFLSSPSLVFR-----DTANLHGKISCFNNF 193
Cdd:cd15389   80 QYCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAI--IWIMASCLSLPHAIYQklvefEYSNERTRSRCLPSF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 slSTPGSSSWpthsqmdpvgysrhMVVTVTRFLCGFLVPVLIITACYLTIVCKL-------------QRNRLAKTKKPFK 260
Cdd:cd15389  158 --PEPSDLFW--------------KYLDLATFILQYVLPLLIIGVAYTRVAKKLwlrnaigdvtteqYVAQRRKKKKTIK 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 261 IIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLataLAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15389  222 MLMLVVLLFAICWLPLNCYHVLLSSHPIRSNSALFFAFHW---LAMSSTCYNPFIYCWLNDSFRS 283
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
45-319 2.06e-20

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 89.84  E-value: 2.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15365    5 FVYIFVIVISIPSNCISLYVSCLQIRKKNELgVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKISCFNNFSLSTPGSSs 202
Cdd:cd15365   85 YTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSfHESSSHTLCYDKFPLEDWQAR- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLA---KTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15365  164 -----------------LNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATedqEKKKIFKLLLLITVTFVICFTPYHVV 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 280 NLLEL---HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFM 319
Cdd:cd15365  227 LLIRSivePCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFV 269
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
41-325 3.98e-20

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 88.93  E-value: 3.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKISNFLL 119
Cdd:cd15165    1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKwTESTIYMINLALNDLLLLLSLPFKMHSSK--KQWPLGRTLCSFLESLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtaNLHGKISCFNNFSLSTpg 199
Cdd:cd15165   79 FVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHD--KPTNNTRCFHGFSNKT-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdpvgYSRHMVVTVTRFlcGFLVPVLIITACYLTIVCKLQRNRLA-----KTKKPFKIIVTIIITFFLCWC 274
Cdd:cd15165  155 --------------WSKKVIVVVEEF--GFLIPMAVMVFCSVQIIRTLLDMRRPeqpkvKQNKSVKIVLSNLVVFLVCFT 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 275 PYHTLNLLEL----HHTAMPGS--VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15165  219 PYHLGIFLQFlvknDIINDCSTkqSIRLFVQVSMCLANVNCCLDAICYYFILKEFRE 275
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
41-249 4.63e-20

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 89.16  E-value: 4.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHI-TYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGqIWATRQALSRTTIYMLNLATADLLYVCSLPLLIyNYTQKDY-WPFGDFTCRLVRFQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVR-LAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNnfsLST 197
Cdd:cd15379   80 FYTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKkLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYD---LSP 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 198 PGSSswpthSQMDPVGysrhMVVTVTrflcGFLVPVLIITACYLTIVCKLQR 249
Cdd:cd15379  157 PARS-----TAYFPYG----ITLTRT----GFLLPFAARLACYCSMATILCR 195
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
41-325 4.71e-20

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 89.29  E-value: 4.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII--IATFKMKKTVNMvWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKIsnF 117
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILafIKDKKLRTVSNF-FLLNLAVADFLVGLVsMPFYIPYTLTG-KWPFGKVFCKA--W 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFT--SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtanlhgkiscfnnfsl 195
Cdd:cd15048   77 LVVDYTLCtaSALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWD---------------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPTHSQMdpVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-------------------------- 249
Cdd:cd15048  141 LWTGYSIVPTGDCE--VEFFDHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKrsrrrplrsvpilpasqnpsrarsqr 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 250 --NRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLElhhTAMPGS-VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15048  219 eqVKLRRDRKAAKSLAILVLVFLICWAPYTILTIIR---SFCSGScVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
44-325 5.70e-20

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 89.02  E-value: 5.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHItYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd14977    4 MSLSLVIFAVGIIGNLMVLcIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNA-YNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAnlhgKISCFNNfslsTPGSS 201
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVA----RESSLDN----SSLTV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDPVGYSRhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRN----------RLAKTKKPFKIIVTIIITFFL 271
Cdd:cd14977  155 CIMKPSTPFAETYPK--ARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAakeytrgtkkHMKQRRQLAKTVLCLVLVFAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGLPLAT----ALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14977  233 CWLPEHISNILRATLYNEVLIDTRSTLDILDligqFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
42-324 8.78e-20

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 88.23  E-value: 8.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMK--KTVNmVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFLL 119
Cdd:cd15378    2 YLPTMYSIEFVLGFIGNTIVILGYIFCLKnwKSSN-IYLFNLSVSDLAFLCTLPMLVYSYSNG-QWLFGDFLCKSNRYLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPV---WSQNHRSvrlAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLS 196
Cdd:cd15378   80 HANLYSSILFLTFISIDRYLLIKYPFrehILQKKRS---AVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSswpthsqmdpVGYSrhMVVTVtrflCGFLVPVLIITACYLTIVCKL-QRNRLAKT----KKPFKIIVTIIITFFL 271
Cdd:cd15378  157 DATNS----------LIYS--LFLTV----TGFLIPLCVMCFFYYKIALFLkNRNRQLANatsfEKPLTLVILAVVIFSV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 272 CWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-------LAIANSCMNPILYVFMGQDFK 324
Cdd:cd15378  221 LFTPYHVMRNVRIASRLDSIGVSECTLIIIKSlyivtrpIAFLNSVINPVFYFLMGDHFR 280
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
45-325 1.30e-19

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 88.05  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIHN 122
Cdd:cd15123    5 VTYAVIISVGILGNAILIkVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIAD-TWLFGRIGCKLLSFIQLTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscfnnFSLSTPGSSS 202
Cdd:cd15123   84 VGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDL------------YSFRDPEKNT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpTHSQMDPVGYSRHMVVTVTRFLC---GFLVPVLIITACYLTIVCKL--------------QRNRLAKTKKPFKIIVTI 265
Cdd:cd15123  152 --TFEACAPYPVSEKILQEIHSLLCflvFYIIPLSIISVYYFLIARTLykstfnmpaeehshARKQIESRKRVAKTVLVL 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 266 IITFFLCWCPYHTLNLLE--LHHTAMPGSVFSLGLPL-ATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15123  230 VALFAFCWLPNHILYLYRsfTYHTSVDSSAFHLIATIfSRVLAFSNSCVNPFALYWLSKSFRQ 292
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
41-325 1.69e-19

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 87.14  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIaTFKMKKTVNMVWF--LNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd14988    1 VVLFILYLVIFVVGLVENVLVIWV-NWHRWGSKNLVNLyiLNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDR--CISVLLPVWSQNHRSVRLAymACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnfsls 196
Cdd:cd14988   80 YFANMYSSIFFLTCLSVDRylTLTSSSPFWQQHQHRIRRA--LCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLF------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgSSSWPTHSQMdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd14988  152 ---LAPFETYDEW-------ALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPY 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 277 H-TLNLLELHHTAMPGSVFSLGL-----PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14988  222 HvTLLLLTLHGSHISLHCNLVHFlyffyDVIDCFSLLHCVANPILYNFLSKSFRG 276
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
41-324 4.99e-19

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 86.00  E-value: 4.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTV-NMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15370    1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHpAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLhgkiscfNNFSLSTPG 199
Cdd:cd15370   81 YGNMYCSILFMTCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFI-------PALDITTCH 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQ-----RNRLAKTKKPFKIIVTIIITFFLCWC 274
Cdd:cd15370  153 DVLPEQLLVGDMFNYFLSLAIGV------FLFPAFLTAVAYVLMIRALKssindESIEKKRKRAIKLIVTVLVMYLICFT 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 275 PYHTlnLLELHHTAMPGSVFSLGLPL---ATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15370  227 PSNL--LLVVHYFLLKNQGQSSVYAFyitALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
43-325 6.07e-19

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 85.97  E-value: 6.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMdYHWVFGTAMCKISNFLLIH 121
Cdd:cd15154    3 HLVGYSLLFPVGLLLNAVALWVFVRYLRlHSVVSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGSIFQM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAN--LHGKIS--CFNNFSLST 197
Cdd:cd15154   82 NMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDclLHGEKVyrCFESFSDND 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGssswpthsqmdpvgysRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT---KKPFKIIVTIIITFFLCWC 274
Cdd:cd15154  162 WK----------------GLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQgrrRKTVRLLLVNLVIFLICFV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 275 PYHTL---------NLLELHHTAMPgSVFSLgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15154  226 PYNTTlavygllraNLVEDTWNIKD-TLRKV-LSVTVLLASTNCALDPLVYYFSTEGFRN 283
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
41-325 7.10e-19

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 85.64  E-value: 7.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIyVVIKFKNMRTVTNFFIANLAVADLMVNTLcLPFTLVYTLLD-EWKFGAVLCHLVPYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDR--CISVLLpvwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkISCFNNFSLS 196
Cdd:cd15399   80 QALAVHVSTVTLTVIALDRhrCIVYHL----ESKISKKISFLIIGLTWAASALLASPLAIFREYSV----IEISPDFKIQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TpGSSSWPTHSQMDPVGYSRHMVvtvtrfLCGFLVPVLIITACYLTIVCKLqRNRLA----------KTKKPFKIIVTII 266
Cdd:cd15399  152 A-CSEKWPNGTLNDGTIYSVSML------LIQYVLPLAIISYAYIRIWTKL-KNHVSpgggndhyhqRRRKTTKMLVCVV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 267 ITFFLCWCPYHTLNL-LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15399  224 VVFAVSWLPFHAFQLaSDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRT 283
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
43-325 8.51e-19

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 85.19  E-value: 8.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTShRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHG-KISCFNNFSLstpg 199
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTvEILVTqDGQEEEICVL---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-NRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15012  158 -----------DREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKsSSIEARRKVVRLLVAVVVSFALCNLPYHA 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 279 LNLLELHHTAMPGS--VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15012  227 RKMWQYWSEPYRCDsnWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
41-324 9.55e-19

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 85.26  E-value: 9.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGN--GLVIIIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15166    1 IAALVFYSFIFIIGLFVNitALWVFSCTTKKRTTVT-VYMMNVALVDLIFILSLPFRMVYYAKD-EWPFGDYFCRILGAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscfnnfslstp 198
Cdd:cd15166   79 TVFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPD---------------- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHM-VVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTK-----KPFKIIVTIIITFFLC 272
Cdd:cd15166  143 KASNFTTCLKMLDIIHLKEVnVLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGRTSKLKpkvkeKSIRIIITLIVQVLVC 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 273 WCPYHTLNLLELHHTAMPGsvFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15166  223 FVPFHICFAFLMLQNGDNS--YNPWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
42-320 9.88e-19

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 85.15  E-value: 9.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15110    2 IEVWVSLIICLLGLVGNGIVLWFLGFRIRRNPFTVYILHLAIADFTFLLCIFILSIMYIGPFNFSHSRDYVAMLIFIILF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 nMF---TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstp 198
Cdd:cd15110   82 -LFgynTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMTSLEYLMCIDEGFHVRNECRAVL----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmdpvgysrhMVVTVTRFLCgfLVPVLIITAcyLTIVCKLQRNRLAK-TKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15110  156 -------------------IFIGILTFLV--FTPLMLISS--LILFIKVRCNSQRRhPGKLYIIIMLTVIFFLIFAMPMR 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 278 TLNLLELHHTampgSVFSLGLPLATALAIANSCMNPILYVFMG 320
Cdd:cd15110  213 VLLLLNYLHH----SSFLFSNPVPFLLSTVNSSINPIVYFLVG 251
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
42-325 1.10e-18

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 84.72  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISNFLL 119
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILaVATTRRLRTITNCYIVSLATADLLVGVLvLPLAIIRQLLGY-WPLGSHLCDFWISLD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnnfslstpg 199
Cdd:cd15061   80 VLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV----------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15061  137 GPSWHGRRGLGSCYYTYDKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIAKER-----KTAKTLAIVVGCFIVCWLPFFIM 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 280 NLLELHHTAMPGSVFSlglPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15061  212 YLIEPFCDCQFSEALS---TAFTWLGYFNSVINPFIYAFYNKDFRR 254
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
46-324 1.20e-18

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 84.82  E-value: 1.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCF-LGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYaaMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15923    5 AIYIPTFvLGLLLNILALWVFCWRLKKwTETNIYMTNLAVADLLLLISLPFKMHS--YRRESAGLQKLCNFVLSLYYINM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgKISCFNNFslstpgSSSW 203
Cdd:cd15923   83 YVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSNE---KTMCFQRT------KQTE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PTHSQMDPVgysrhmvvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRL-----AKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15923  154 SLKVFLLLE-------------IFGFLLPLIIMTFCSARVIHTLQKRLDdvgsrSETKQCIRVIMANLIVFIVCFLPVHV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 279 LNLLEL----HHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15923  221 GFFVKFivgkSYSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 2.78e-18

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 84.15  E-value: 2.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIHN 122
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMwIILAHKRMRTVTNYFLVNLAFAEASMSAFnTVINFTYAIHN-EWYYGLEYCKFHNFFPIAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNfslstpgsss 202
Cdd:cd16002   84 VFASIYSMTAIALDRYMAIIHPL--QPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVE---------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 WPTHSQMDpvgYSRHMVVTVTRFLcgFLVPVLIITACYLTIVCKL------------QRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd16002  152 WPEHEERK---YETVYHVCVTVLI--YFLPLLVIGCAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFA 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFK 324
Cdd:cd16002  227 ICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIMwLAMSSTMYNPIIYCCLNDRFR 281
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
42-319 5.17e-18

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 82.92  E-value: 5.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15371    2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSLSTPG 199
Cdd:cd15371   82 NMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKelNITTCHDVLPECEQN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVgysrhmvvtvtrflCGFLVPVLIITACYLTIVCKLQRNRlAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15371  162 SNFQFYYFISMAV--------------FGFLIPLVITIFCYISIIRTLNAYE-HKWFWYVKITALVLIIFTICFAPSNVI 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 215272319 280 NLLEL--HHTAMPGSVFSLGLpLATALAIANSCMNPILYVFM 319
Cdd:cd15371  227 LIIHHfnYYYFNNDNLYSIYL-IALCLGSLNSCLDPFLYFLM 267
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
41-325 5.31e-18

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 82.90  E-value: 5.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15364    1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRrKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtANLHGKISCFNNFslstpg 199
Cdd:cd15364   81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRE-GQTEGSHTCFETL------ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswPTHSQMDPVGYSrhmvvtvtRFLCGFLVP--VLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFL-CWCPY 276
Cdd:cd15364  154 ----QMDTQVAGFYYA--------RFCIGFAIPlaILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLiCFAPY 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 277 HTLNLLE-LHHTAMPGSVFSLGLPLATALAI------ANSCMNPILYVFMGQDFKK 325
Cdd:cd15364  222 HLVLLVRaIAFSLYPNGMCGFEERIYTPSVIflclstVNSVADPIIYVLVSENVRQ 277
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
43-325 5.86e-18

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 83.25  E-value: 5.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNmvwFL--NLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNF 117
Cdd:cd15394    3 IIPLYSLVVLVGVVGNYLLIyvICRTKKMHNVTN---FLigNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVwsqnHRSVRLAYMACMV--IWVLAFFLSSPSLVFRDTANL--HGKISCfnnf 193
Cdd:cd15394   80 MQPVTVYVSVFTLTAIAVDRYYVTVYPL----RRRISRRTCAYIVaaIWLLSCGLALPAAAHTYYVEFkgLDFSIC---- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 slstpgSSSWpTHSQMDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLqRNRL--------------AKTKKPF 259
Cdd:cd15394  152 ------EEFW-FGQEKQRLAYACSTLLIT------YVLPLLAISLSYLRISVKL-RNRVvpgsmtqsqaewdrARRRKTF 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15394  218 RLLVVVVVAFAICWLPLHIFNVIrDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
41-324 7.42e-18

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 82.95  E-value: 7.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITyAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15391    1 PHLINLYQSTIFLSVGGNYSVIVVfYDGRRSRTDLNYYLINLAVSDLIMALFcMPFTFT-QIMLGHWVFPAPMCPIVLYV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMAcmVIWVLAFFLSSPSLvFRDTANLHGKISCFnnfslSTP 198
Cdd:cd15391   80 QLVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIA--SIWAISFSLSSVQL-FAGRTQRYGQYSEG-----RVL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSqmdpvgYSRhMVVTVTRFLCGFLVPVLIITACYLTIVCKL-------------QRNRLAKTKKPFKIIVTI 265
Cdd:cd15391  152 CGESWPGPD------TSR-SAYTVFVMLLTYIIPLLILTSTYGYVGFRLwnrtapgnadkgrDDMQIKSKRKVIKMLVFV 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 266 IITFFLCWCPYHTLNLLELHHT---AMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15391  225 VLMFGICWLPLHLFNLVQDFSTvfrNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 1.01e-17

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 82.29  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIwIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACmvIWVLAFFLSSPSLVFRDTANLHGKISCFnnfslstpgsSSW 203
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGS--IWILAFLLAFPQCLYSKTKVMPGRTLCF----------VAW 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PThsqmdpvGYSRHMVVTVTRFLCGFLVPVLIITACYlTIV-------------CKLQRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd16003  153 PG-------GPDQHFTYHIIVIVLVYCLPLLVMGITY-TIVgitlwggeipgdtSDKYHEQLRAKRKVVKMMIIVVLTFA 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFK 324
Cdd:cd16003  225 ICWLPYHIYFIVTGLYQQLNRWKYIQQVYLASFwLAMSSTMYNPIIYCCLNKRFR 279
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
43-325 1.12e-17

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 82.26  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGN-GLVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15124    3 IPTVYGIIILIGLIGNiTLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLAD-EWLFGRVGCKLIPFIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiSCFNNFSLSTPgs 200
Cdd:cd15124   82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDK-STNKTFVSCAP-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 ssWPTHSQMDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVCKL--------------------QRNRLAKTKKPFk 260
Cdd:cd15124  159 --YPHSNELHPKIHS------MASFLIFYVIPLSIISVYYYFIAKNLirsaynlpvegnvhvrrqieSRKRLAKTVLVF- 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 261 iivtiIITFFLCWCPYHTLNLLELHH-----TAMPGSVFSLglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15124  230 -----VGLFAFCWLPNHIIYLYRSYHysevdTSMLHFVSSI---CARILAFTNSCVNPFALYLLSKSFRK 291
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
41-324 1.52e-17

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 81.54  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHwvfGTAMCKISNFLL 119
Cdd:cd15164    1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKwTETRVYMINLAVADCCLLFSLPFVLYFLKHSWP---DDELCLVLQSIY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFlsspSLVFRDTANLHGKISCFNNFSlstpg 199
Cdd:cd15164   78 FINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVII----SVSLRLAWEEQEENFCFGKTS----- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR--NRLAKTKKPFK----IIVTIIITFFLCW 273
Cdd:cd15164  149 ---------------TRPSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKkkKTNPHEEKLIQkaiyIVSANLIVFIVCF 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 274 CPYHTLNLLELHHTAMPGS-----VFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15164  214 LPLHIGLLVRFVMESNKAScsliqNIRNFIYVASCLANANCCLDAICYYFVAKEFQ 269
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
45-325 1.95e-17

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 81.31  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVFLPIHITYAaMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15152    5 VTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMiNLAIADLLQVLSLPLRIFYY-LNKSWPFGKFLCMFCFYLKYVNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMaCMVIWVLAFFLSSPSLVFRdTANLHGKISCFNNFSLSTpgsssw 203
Cdd:cd15152   84 YASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYI-SIAGWLVVCVGCLPFPLLR-QSQDTNPTCCFADLPLRN------ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 pthsqmdpVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNR-----LAKTKKPFKIIVTIIITFFLCWCPYH- 277
Cdd:cd15152  156 --------VGLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTpvlqdLGEKKKALKMILTCAVVFLICFAPYHi 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 278 --TLNLLELHHTAMPGS---VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15152  228 sfPLDFLVKSNKIKSCTarkVILIFHPVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
41-326 1.99e-17

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 81.68  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15922    1 PAIPVFLSLVFLGGFLLNSFSLWIFWFRIKQwSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFslstpg 199
Cdd:cd15922   81 STHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIH------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswptHSQMDPVGYSRHMVVTVTrflcGFLVPVLIITACYLTIVCKL-------QRNRLAKTKKpFKIIVTIIITFFLC 272
Cdd:cd15922  155 ------QSELSLLYFVWNFVLLIL----GFLLPFGVSLTCYALLGASIakmnsnnARGRAMKAKS-LQMIGISLVIFIIC 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 273 WCPyhtlnlleLHHTAMPGSVFSLGLPLATA--------------LAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15922  224 FVP--------LHVTRTVGVVVKLFYPESCTllhkvevayyiswvLTGVNCCLDPLLYCFASEKFRKS 283
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
44-325 2.73e-17

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 81.26  E-value: 2.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKKTVNMV--WFLNLAVADFLFN-VFLPIHITYAAMdYHWVFGTAMCKISNFLLI 120
Cdd:cd15383    4 VAVTFVLFVLSACSNLAVLWSATRNRRRKLSHVriLILHLAAADLLVTfVVMPLDAAWNVT-VQWYAGDLACRLLMFLKL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACmVIWVLAFFLSSPSLVFRDTANLHGKIscfnNFS-LSTPG 199
Cdd:cd15383   83 FAMYSSAFVTVVISLDRHAAILNPLAIGSARR-RNRIMLC-AAWGLSALLALPQLFLFHTVTATPPV----NFTqCATHG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssSWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-------------------NRLAKTK-KPF 259
Cdd:cd15383  157 --SFPAHWQ--------ETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRrmkekkdsaknevalrsssDNIPKARmRTL 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLLELHHTAM-----PGSV----FSLGLplatalaiANSCMNPILYVFMGQDFKK 325
Cdd:cd15383  227 KMTIVIVSSFIVCWTPYYLLGLWYWFSPEMleqtvPESLshilFLFGL--------LNACLDPLIYGLFTISFRR 293
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
41-325 2.96e-17

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 80.45  E-value: 2.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAaILLTRKLHTPANYLIASLAVADLLVAVLvMPLSAVYELTG-RWILGQVLCDIWISL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnfslstp 198
Cdd:cd15064   80 DVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECL-------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmdpvgYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15064  152 ---------------ISQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAARER-----KAAKTLGIILGAFIVCWLPFFL 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 279 LNLLE--LHHTAMPGSVFSLglplATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15064  212 VALIVplCSHCWIPLALKSF----FLWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
42-318 3.14e-17

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 80.74  E-value: 3.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWF-LNLAVADFLFNVF--LP---IHITYaamdyhwVF--GTAMCK 113
Cdd:cd15196    2 VEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFiLHLSVADLLVALFnvLPqliWDITY-------RFygGDLLCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 114 ISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACmVIWVLAFFLSSPSL-VFRDTANLHGKISCFNN 192
Cdd:cd15196   75 LVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVA-IAWVLSLLLSIPQLfIFSYQEVGSGVYDCWAT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 193 FSLSTpgssswpthsqmDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLaktkKPFKIIVTIIITFFLC 272
Cdd:cd15196  154 FEPPW------------GLRAYITWFTVAV------FVVPLIILAFCYGRICYVVWRAKI----KTVKLTLVVVACYIVC 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 273 WCPYHTLNLLELHHTAMP--GSVFSLGLPLATalaiANSCMNPILYVF 318
Cdd:cd15196  212 WTPFFVVQMWAAWDPTAPieGPAFVIIMLLAS----LNSCTNPWIYLA 255
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
49-325 3.33e-17

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 80.75  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKK--TVNMVWFLNLAVADFLFNVFLPIhITYAAMDYHWVFG--------TAMCKISNFL 118
Cdd:cd14980    9 IIGILALIGNILVIIWHISSKKKkkKVPKLLIINLAIADFLMGIYLLI-IAIADQYYRGRYAqyseewlrSPPCLLACFL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwsQNHR-SVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNnfSLST 197
Cdd:cd14980   88 VSLSSLMSVLMMLLITLDRYICIVYPF--SNKRlSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGYS--SICM 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPthsqmdpvgYSRHMVVTVTrfLCGFLVpVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFL------ 271
Cdd:cd14980  164 PSNVSNP---------YYRGWLIAYL--LLTFIA-WIIICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALilitdl 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 272 -CWCPYHTLNLLELhhtAMPGSVFSLGLPLATALAIA-NSCMNPILYVFMGQDFKK 325
Cdd:cd14980  232 iCWLPYYIVIFSGL---LTSTEIDIHVLQFIAILALPlNSAINPYLYTLTTPTFKR 284
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
43-325 4.78e-17

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 80.09  E-value: 4.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILaVLRERYLRTVTNYFIVSLAVADLLVGsIVMPFSILHEMTGGYWLFGRDWCDVWHSFDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscfnnfslSTPGS 200
Cdd:cd15067   82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRA---------------VDPGP 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYltivCKLQRNRlAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15067  147 SPPNQCLFTDDSGY------LIFSSCVSFYIPLVVMLFTY----YRIYRAA-AKEQKAAKTLGIVMGVFILCWLPFFVTN 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 281 LLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15067  216 ILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRR 260
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
41-325 6.32e-17

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 80.18  E-value: 6.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15924    1 QLFPVLYTVIFFAGILLNGLAMWIFFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdTANLHGKISCFNNFSLSTPGS 200
Cdd:cd15924   81 FTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMIL--TNQQPREKNVKKCSFLKSELG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWpthsqmdpvgysrHMVVTVTrFLCGFLVPVLIITACYLTIVCKL-------QRNRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15924  159 LKW-------------HEIVNYI-CQVIFWIVFLLMIVCYTAITKKVyrsyrrvFRSSSSRRKKSNVKIFIIVAVFFVCF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 274 CPYH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15924  225 VPYHfaripyTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
41-244 7.38e-17

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 79.61  E-value: 7.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII--IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15170    1 WLVLAVYIITFLIGLPANLLAFYtfIRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSS-----PSLVFRDTANLHGKISCFNNF 193
Cdd:cd15170   81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHCSivyivEYHIDSENTSVTNNSRCYDNF 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 194 slstpgssswpTHSQMDPVgysrhMVVTVTRFLCGFLVPVLIITACYLTIV 244
Cdd:cd15170  161 -----------TPEQLKIL-----LPVRLELFLVLFCIPFLITCFCYINFI 195
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
41-325 1.75e-16

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 78.91  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTcIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYPWVFGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscfnNFSLSTP 198
Cdd:cd15134   81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRI-----------VYLEYPP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHMVVTVTRFLCG--FLVPVLIITACYLTIVCKLQRNRLAK---------------TKKPFKI 261
Cdd:cd15134  150 TSGEALEESAFCAMLNEIPPITPVFQLSTFlfFIIPMIAIIVLYVLIGLQLRRSTLLRrgqrsvsggrrssqsRRTVLRM 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 262 IVTIIITFFLCWCPYHTLNLLELHHTAMPGS---VFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15134  230 LVAVVVAFFICWAPFHAQRLLTVYAKNMTPPylfINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-325 2.23e-16

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 78.45  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGN-GLVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15125    6 LYLLIITVGLLGNiTLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYE-EWMFGTVGCKLIPVIQLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAnlHGKISCFNNFSLSTPgsssW 203
Cdd:cd15125   85 GVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVA--HIMPDDNTTFTACIP----Y 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PTHSQMDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRN-------------RLAKTKKPF-KIIVTIIITF 269
Cdd:cd15125  159 PQTDEMHPKIHS------VLIFLVYFLIPLAIISIYYYHIAKTLIKSahnipgeysehskRQMETRKRLaKIVLVFVGLF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 270 FLCWCPYHTLNLLE-LHHTAMPGSVFSLGLPL-ATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15125  233 AFCWFPNHVLYMYRsFNYNEIDSSLGHMIVTLvARVLSFCNSCVNPFALYLLSESFRR 290
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
42-324 2.91e-16

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 77.89  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNgLVIIIATFKMKKTVNMVWFL--NLAVADFLFNVFL-PIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15398    2 FLIGLYTFISLLGFLGN-LLILTALTKKWKQKTIINFLigNLAFSDILVVLFCsPFTLTCVLLD-QWIFGEVMCHIVPFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHgkiSCFNNFSLSTP 198
Cdd:cd15398   80 QCVSVMVSTLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLS---ETFNLESLKNK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 G--SSSWPTHSQmdpvgysrHMVVTVTRFLCGFLVPVLIITACYlTIVCKlqrnRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15398  155 YlcIESWPSDSY--------RIAFTISLLFVQYILPLVCLTVSH-TSVCR----SVKRSRSVFYRLTIVILAFAVSWMPL 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 277 HTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15398  222 HLFHLVtDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIK 270
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
42-339 3.04e-16

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 78.79  E-value: 3.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyhWVFGTAMCKISNFLLIH 121
Cdd:PHA02834  30 FVIVFYILLFIFGLIGNVLVIAVLIVKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNE--WIFGEFMCKLVLGVYFV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNhRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISC-FN----NFSLS 196
Cdd:PHA02834 108 GFFSNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCiFNdyheNFSWS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TpgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:PHA02834 187 A---------------------FFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPF 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 277 ---------HTLNLLELHHTAMPGSVFSLGlpLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALS 339
Cdd:PHA02834 246 nivlfinslQSVGLIDIGCYHFKKIVYSID--IAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCRTNNIFI 315
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
41-325 3.16e-16

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 77.91  E-value: 3.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKIsnFL 118
Cdd:cd15296    1 VILAVLMALLVVATVLGNALVILaFVVDSSLRTQGNFFFLNLAISDFLVGGFcIPLYIPYV-LTGRWKFGRGLCKL--WL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMF--TSVFLLTIISSDRCISVLLPVWSQNHRSV-RLAYMACMVIWVLAFFLSSPSLVFRDtanlhgkiscfnnfsl 195
Cdd:cd15296   78 VVDYLLctASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFLLYGPAIISWE---------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPTHSQMDPVGYSRHMVVTVTRFlcGFLVPVLIITACYLTIVCKLQRN--RLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15296  142 YIAGGSIIPEGECYAEFFYNWYFLMTASTL--EFFTPFISVTYFNLSIYLNIQKRrfRLSRDKKVAKSLAIIVCVFGLCW 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 274 CPYHTLNLLE--LHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15296  220 APYTLLMIIRaaCHGHCVPDYWYETSF----WLLWVNSAINPVLYPLCHMSFRR 269
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
44-325 3.51e-16

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 78.21  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIaTFKMKKTVNMVWFL--NLAVADFLFNVF-LPIHITYAAMdYHWVFGTAMCKISNFLLI 120
Cdd:cd15195    4 VLVTWVLFVISAAGNLTVLIQ-LFRRRRAKSHIQILimHLALADLMVTFFnMPMDAVWNYT-VEWLAGDLMCRVMMFLKQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMViWVLAFFLSSPSLVFRDTanlhGKISCFNNFSLSTPGS 200
Cdd:cd15195   82 FGMYLSSFMLVVIALDRVFAILSPL-SANQARKRVKIMLTVA-WVLSALCSIPQSFIFSV----LRKMPEQPGFHQCVDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDPVgysrHMVVtvtrFLCGFLVPVLIITACYLTIVCKLqrNRLAKT---------------------KKPF 259
Cdd:cd15195  156 GSAPTKKQERLY----YFFT----MILSFVIPLIITVTCYLLILFEI--SKMAKRardtpisnrrrsrtnslerarMRTL 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 260 KIIVTIIITFFLCWCPYHtlnLLELHHTAMPGSVFSLGLPLATALAI---ANSCMNPILYVFMGQDFKK 325
Cdd:cd15195  226 RMTALIVLTFIVCWGPYY---VLGLWYWFDKESIKNLPPALSHIMFLlgyLNPCLHPIIYGVFMKEIRN 291
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
41-325 3.90e-16

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 77.24  E-value: 3.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILsVACHRHLQTVTHYFIVNLAVADLLLtSTVLPFSAIFEILGY-WAFGRVFCNIWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlhgkiscfnnFSLSTP 198
Cdd:cd15325   80 DVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPL-----------------FGWKEP 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTI-VCKLqrnRLAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15325  143 APEDETICQITEEPGYA------LFSALGSFYLPLAIILVMYCRVyVVAL---KFSREKKAAKTLGIVVGCFVLCWLPFF 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 278 TLnllelhhtaMP-GSVFSLGLPLATALAIA------NSCMNPILYVFMGQDFKK 325
Cdd:cd15325  214 LV---------MPiGSIFPAYKPSDTVFKITfwlgyfNSCINPIIYPCSSQEFKK 259
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
42-323 6.34e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 77.12  E-value: 6.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15200    2 FLAPVLGIEFVLGLVGNGIALFIFCFHRRPwKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvfrdTANLHGKISCFNNFSLSTPGS 200
Cdd:cd15200   82 MNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLL----LLDHVQSNSTCLSYDHGTDPS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMdpvgysrhmvvtvtrFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP---FKIIVTIIITFFLCWCPYH 277
Cdd:cd15200  158 ASDRWHRIL---------------FFLEFFLPLGIILFCIFSIILTLKQRKLAKQAGPqraVKVLAVIVLVYTVCFLPSI 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 278 TLNLLELhhtampgSVFSLGLPL-----------ATALAIANSCMNPILYVFMGQDF 323
Cdd:cd15200  223 LFALASL-------VAFKVSQCRsldlctqlfhgSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
43-325 6.54e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 76.79  E-value: 6.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKIsnFLLI 120
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIaFVVDKNLRHRSNYFFLNLAISDFFVGAIsIPLYIPYT-LTNRWDFGRGLCVF--WLVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMF--TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMV-IWVLAFFLSSPSLVFrdtanlhgkiscfnnfslst 197
Cdd:cd15295   80 DYLLctASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVaVWVLAFLVHGPAILV-------------------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgSSSWPTH-SQMDPVGYSRHMVVTVTRFLcGFLVPVLIITACYLTIVCKLqRNRLaKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15295  140 --SDSWKTEdGECEPEFFSNWYILAITSVL-EFLVPVILVAYFNTQIYWSL-WKRL-RDRKLAKSLAIILGTFAICWAPY 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 277 HTLNLLELHHTAMPGSVFslgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15295  215 SLFTIIRAACEKHRGSPW---YNFAFWLQWFNSFINPFLYPLCHKRFRK 260
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
41-325 6.84e-16

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 77.14  E-value: 6.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15969    1 IVFPVLYLIIFIGSILLNGLAVWIFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKIscFNNFSLSTPGS 200
Cdd:cd15969   81 ASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNI--HDCSKLKSPLG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWpthsqmdpvgysrHMVVTVTRfLCGFLVPVLIITACYLTIVCKLQRNR------LAKTKKPFKIIVTIIITFFLCWC 274
Cdd:cd15969  159 VKW-------------HTAVSYIN-ICIFVAVLVILIVCYISISRYIYKSSkqfissSSRTRKHNQSIRVVVAVFFVCFL 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 275 PYH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15969  225 PYHlcripfTFSQLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
43-325 6.85e-16

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 77.23  E-value: 6.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15980    3 FIASYLLIFLLCMMGNGVVcFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTP--- 198
Cdd:cd15980   83 SVSASVFTLVAIAVDRFRCIVYPF--KQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPvyw 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQmdpvgysRHMVVTVTrFLCGFLVPVLIITACYLTIVCKL--------------QRNRLAKTK-KPFKIIV 263
Cdd:cd15980  161 CREDWPNQEM-------RKIYTTVL-FANIYLAPLSLIVIMYARIGITLfktamphtgkhnqeQRHVVSRKKqKVIKMLL 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 264 TIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGL---PLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15980  233 IVALLFILSWLPLWTLMMLSDYANLSPNQLQIINIyiyPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
41-325 1.11e-15

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 76.16  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIaVCLVKKLRTPSNYLIVSLAVSDLLVALLvMPLAIIYELSGY-WPFGEILCDVWISF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLayMACMVI--WVLAFFLSSPSLvFRDTANLHGKISCFnnfsls 196
Cdd:cd15329   80 DVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKR--MALMIAivWLLSALISIPPL-FGWKNKVNDPGVCQ------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgssswpthsqmdpvgYSRHMVVTVTRFLCGFLVPVLIITACYLTIVcklqrnRLAKT-KKPFKIIVTIIITFFLCWCP 275
Cdd:cd15329  151 -----------------VSQDFGYQIYATFGAFYIPLIVMLVLYYKIY------RAAKSeRKAIKTLGIIMGAFTLCWLP 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 276 YHTLNLLE-----LHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15329  208 FFILALLRpflkpIKCSCIPLWLSRLFL----WLGYANSFLNPIIYAKFNREFRT 258
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
45-325 1.17e-15

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 76.23  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMsVFRERSLQTATNYFIVSLAVADLLVAILvMPFAVYVEVNGGKWYLGPILCDIYIAMDVMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSL-VFRDTANLHGKISCFNNfslstpgss 201
Cdd:cd15053   85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLfGLNNVPYRDPEECRFYN--------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 swpthsqMDPVGYSRhmvvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15053  156 -------PDFIIYSS---------ISSFYIPCIVMLLLYYRIFRALRREK-----KATKTLAIVLGVFLFCWLPFFTLNI 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 282 LELH-------HTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15053  215 LNAIcpklqnqSCHVGPALFS----LTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-325 1.24e-15

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 76.66  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIiATFKMK--KTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLL 119
Cdd:cd15208    3 LIALYILVFIVGLVGNVLVCF-AVWRNHhmRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTE-TWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRsvRLAYMACMVIWVLAFFLSSPSLVFRDTANLhgkISCFNNFSLSTPG 199
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTA--KRARVSILIIWIVSLLIMIPQAIVMECSRV---VPLANKTILLTVC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQmdPVGYsrHMVVtvtrFLCGFLVPVLIITACYLTIVCKL--------------------------QRNRLA 253
Cdd:cd15208  156 DERWSDSIY--QKVY--HICF----FLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnkprksavaaEEKQLR 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 254 KTKKPFKIIVTIIITFFLCWCPYHTLNLLE---LHHTAMPGSVFSLGLpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15208  228 SRRKTAKMLIVVVIMFAICYLPVHLLNILRyvfGLFTVDRETIYAWFL-FSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
50-190 2.88e-15

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 75.18  E-value: 2.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  50 VCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLF---NVFLPIHITYAAMDYHWVFGTAMCKISNFLLIhnmfTS 126
Cdd:cd15108   10 TCVCGMAGNGLVVWLLSCRGRRTPFCVYVLHLAVADLLFllcMASTLSLETSPLVITHDLAYEVVRRVKYFAYT----AS 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCF 190
Cdd:cd15108   86 LSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSEFWHPDEWQCF 149
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
43-324 3.03e-15

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 75.47  E-value: 3.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGL-VIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd14979    3 VTAIYVAIFVVGIVGNLLtCIVIARHKSLRTTTNYYLFSLAVSDLLILLVgLPVELYNFWWQYPWAFGDGGCKLYYFLFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGkisCFNnfslSTPGS 200
Cdd:cd14979   83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNG---PLP----GPVPD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT-------------------KKPFKI 261
Cdd:cd14979  156 SAVCTLVVDR----STFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKgtraqgtrnvelslsqqarRQVVKM 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 262 IVTIIITFFLCWCPYHTLNLLELHHTAMPGS---VFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd14979  232 LGAVVIAFFVCWLPFHAQRLMFSYASKEDTFlfdFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
41-258 3.20e-15

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 75.40  E-value: 3.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIII--ATFKMKKTVNmVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNF 117
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVvwKNKDMRTPTN-IFLVNLSVADLLVLLVcMPVALVETWAREPWLLGEFMCKLVPF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgKISCFNNFSLS- 196
Cdd:cd14997   80 VELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEF-----KEEDFNDGTPVa 154
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 197 ---TPGSSSWpthsqmdPVGYsrhMVVTVTRFlcgFLVPVLIITACYLTIVCKLQRNRLAKTKKP 258
Cdd:cd14997  155 vcrTPADTFW-------KVAY---ILSTIVVF---FVVPLAILSGLYSVICRRLVGHPALESRRA 206
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
45-326 6.98e-15

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 74.40  E-value: 6.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMV--WFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLwVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrDTANLHGKIS-----CFNNFSls 196
Cdd:cd15147   85 NTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFM-DSTNTVKIDSgnftrCFEGYE-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgssswpthsqmdpvgYSRHMVVTVTRF-LCG-FLVPVLIITACYLTIVCKL-----QRNRLAKTK-KPFKIIVTIIIT 268
Cdd:cd15147  162 -----------------KDNSKPVLIIHFiIIGlFFLVFLLILVCNLVIARTLlsqpvQGQRNAGVKrRALWMVCTVLAV 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 269 FFLCWCPYH------TLNLLELHHTAMPGSVFSLGLPLATALAI--ANSCMNPILYVFMGQDFKKF 326
Cdd:cd15147  225 FVICFVPHHvvqgpwTLAVLQQWRYWDCQFRQALNDAHQITLCLmsTNCVLDPVIYCFLTKKFRKH 290
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
43-320 9.44e-15

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 73.63  E-value: 9.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFnvfLPIHITYAAMDYHWVFGT-AMCKISNFLLIH 121
Cdd:cd15106    3 LTFLTCIISLVGLTGNAVVLWLLGFRMRRNAFSVYILNLAAADFLF---LCCHIIDSLLRLINIFHIiSIPKILTNVMTF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSpslvfrdtanLHGKISCFnnfsLSTPGSS 201
Cdd:cd15106   80 PYFAGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSI----------LEWKFCGF----LFSGADS 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDPVGYSRHMVVTvtrfLCGFLVPVLIitacylTIVCKLQRNRLAKTkkpFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15106  146 HWCQTFDFITTAWLIFLFVV----LCGSSLALLV------RILCGSRKMPLTRL---YVTILLTVLVFLLCGLPFGIQWF 212
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 215272319 282 LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMG 320
Cdd:cd15106  213 LLLWIHIDLEVLFCHVYLVSVVLSCLNSSANPIIYFFVG 251
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
44-325 1.06e-14

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 73.31  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIH 121
Cdd:cd15979    4 ILLYSVIFLLSVFGNMLIIVVlGLNKRLRTVTNSFLLSLALSDLMLAVFcMPFTLIPNLMG-TFIFGEVICKAVAYLMGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiscfnNFSLSTPGSS 201
Cdd:cd15979   83 SVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVG-----DRPRGHQCRH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPThSQMDPVGYsrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKtKKPFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15979  158 AWPS-AQVRQAWY-------VLLLLILFFIPGVVMIVAYGLISRELYRGLLAK-KRVIRMLVVIVAMFFLCWLPIFSANT 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 282 LELHHTAMPGSVFSlGLPLA--TALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15979  229 WRAFDPLSAHRALS-GAPISfiHLLSYTSACVNPLVYCFMNRRFRK 273
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
46-172 2.48e-14

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 72.25  E-value: 2.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFT 125
Cdd:cd15109    6 IFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGLCTFLT 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 126 SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSS 172
Cdd:cd15109   86 GVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTC 132
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
44-316 2.52e-14

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 72.47  E-value: 2.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNgLVIIIATFKMKKTVNMVW--FLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15384    4 IVVLAVMFVISFIGN-LLTIIQIYRLRRSRRTIYslLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMAcMVIWVLAFFLSSPSLVFRDTANlHGKISCFnnFSLSTPGSS 201
Cdd:cd15384   83 GLYLSTYITVLISLDRCVAILYPM-KRNQAPERVRRMV-TVAWILSPIFSIPQAVIFHVER-GPFVEDF--HQCVTYGFY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMdpvgYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKL-------------------QRNRL---AKTKKpF 259
Cdd:cd15384  158 TAEWQEQL----YNMLSLVFM------FPIPLVIMVTCYVLIFITLskssrdfqgleiytrnrgpNRQRLfhkAKVKS-L 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLLELHHTAMP-GSVFSLGLPLataLAIANSCMNPILY 316
Cdd:cd15384  227 RMSAVIVTAFILCWTPYYVIMIWFLFFNPYPlNDILFDVIFF---FGMSNSCVNPLIY 281
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
41-318 3.51e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 72.13  E-value: 3.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15366    1 LFPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELgVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSL----VFRDTANlhgKISCFNNFSL 195
Cdd:cd15366   81 YTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLfhdeLFRDRYN---HTFCFEKYPM 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 StpGSSSWpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKL------QRNRLAKTKkpfKIIVTIIITF 269
Cdd:cd15366  158 E--DWVAW----------------MNLYRVFVGFLFPWVLMLFSYRGILRAVrgnvstEQQEKAKIK---RLALSLIAIV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 270 FLCWCPYHTLNLLElhhtampgSVFSLGLP--------------LATALAIANSCMNPILYVF 318
Cdd:cd15366  217 LLCFAPYHVLLLSR--------SVVYLGKPcdcgfeervftayhVSLALTSLNCVADPILYCL 271
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
43-325 3.86e-14

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 71.80  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15149    3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTA-NLHGKISCFNnfsLSTPGSS 201
Cdd:cd15149   83 MYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSfHEANYTKCAR---LKSELGI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVC---KLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH- 277
Cdd:cd15149  160 QWHKASNY----------ICVSIFWVVFLLLIIFYVAISRKIYKsnqKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHa 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 278 -----TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15149  230 lripyTLSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFRE 282
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
41-325 4.07e-14

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 71.96  E-value: 4.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFL--NLAVADFLFN-VFLPIHITYAAMdYHWVFGTAMCKISNF 117
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSRVNILlmHLAIADLLVTfIMMPLEIGWAAT-VAWLAGDFLCRLMLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQN-HRSVRLaymacMVI--WVLAFFLSSP-SLVFRDTANLH--GKISC-- 189
Cdd:cd15382   80 FRAFGLYLSSFVLVCISLDRYFAILKPLRLSDaRRRGRI-----MLAvaWVISFLCSIPqSFIFHVESHPCvtWFSQCvt 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 190 FNNFslstpgssswPTHSQMdpVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKL-QRNRLAKTK------------ 256
Cdd:cd15382  155 FNFF----------PSHDHE--LAYNIFNMITM------YALPLIIIVFCYSLILCEIsRKSKEKKEDvseksssvrlrr 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 257 -----------KPFKIIVTIIITFFLCWCPYHTLNLLelhHTAMPGSVFSLGLPLATAL---AIANSCMNPILYVFMGQD 322
Cdd:cd15382  217 ssvgllerarsRTLKMTIVIVLVFIICWTPYFIMSLW---YWFDRESASKVDPRIQKGLflfAVSNSCMNPIVYGYFSID 293

                 ...
gi 215272319 323 FKK 325
Cdd:cd15382  294 LRR 296
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-326 5.67e-14

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 71.69  E-value: 5.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVcflgILGNGLVIIIATFKMKKTVNMVWF-LNLAVADF---LFNVFLPIHITYAAmdyHWVFGTAMCKISN 116
Cdd:cd15197    5 ATLWVLFVFI----VVGNSSVLFALWMRKAKKSRMNFFiTQLAIADLcvgLINVLTDIIWRITV---EWRAGDFACKVIR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPV-WSQNHRSVRLayMACmVIWVLAFFLSSPSLV-FRDTANLHGKISCFnnfs 194
Cdd:cd15197   78 YLQVVVTYASTYVLVALSIDRYDAICHPMnFSQSGRQARV--LIC-VAWILSALFSIPMLIiFEKTGLSNGEVQCW---- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 lstpgsSSWPTHSQMDPVgysrhmvVTVTRFLCgFLVPVLIITACYLTIV-----------------CKLQRNRLAKTK- 256
Cdd:cd15197  151 ------ILWPEPWYWKVY-------MTIVAFLV-FFIPATIISICYIIIVrtiwkkskiqvtinkagLHDGSSRRSSSRg 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 257 -------KPFKIIVTIIITFFLCWCPYHTLNLLE----LHHTAMPGSVfslgLPLATALAIANSCMNPILY-VFMGQDFK 324
Cdd:cd15197  217 iiprakiKTIKMTFVIVTVFIICWSPYFVFDLLDvfglLPRSKTKIAA----ATFIQSLAPLNSAINPLIYcLFSTHLCR 292

                 ..
gi 215272319 325 KF 326
Cdd:cd15197  293 PL 294
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
41-325 5.94e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 71.15  E-value: 5.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMK---KTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISN 116
Cdd:cd17790    1 VLIVITTGILSLVTVTGNLLVLI--SFKVNselKTVNNYFLLSLACADLIIGAFsMNLYTTYILMG-HWALGTVACDLWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKI---SCFNNF 193
Cdd:cd17790   78 ALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVlagQCYIQF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 sLSTPgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVcklqrNRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd17790  158 -LSQP--------------------IITFGTAIAAFYLPVTIMIILYWRIY-----RETIKEKKAARTLSAILLAFILTW 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 274 CPYHTLNLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd17790  212 TPYNIMVLVSTFcKDCVPKTLWELGY----WLCYVNSTVNPMCYALCNKSFRD 260
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
41-325 6.76e-14

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 71.35  E-value: 6.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIyVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRdtaNLHGKISCFNNFSLSTPG 199
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQ---QLEVKYDFLYEKRHVCCL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSW-PTHSQMdpvgYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKL-------------------QRNRLAKTKKPF 259
Cdd:cd15205  158 ERWYsPTQQKI----YTTFILVIL------FLLPLTTMLFLYSRIGYELwikkrvgdasvlqtihgieMSKISRKKKRAV 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIA--NSCMNPILYVFMGQDFKK 325
Cdd:cd15205  228 KMMVTVVLLFAVCWAPFHVVHMMiEYSNLENKYDGVTIKLIFAIVQLIGfsNSFNNPIVYAFMNENFKK 296
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
42-324 7.92e-14

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 71.01  E-value: 7.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCF-LGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVfgTAMCKISNFLL 119
Cdd:cd14989    1 FLSCLYTIFLFpIGFIGNILILVVnLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDI--AVLCTFMSLFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNfslstpg 199
Cdd:cd14989   79 QINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFAD------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 ssswpthsqmdpVGYSRHMVVTVtrflcGFLVPVLIITACYLTIVCKLQR----NRL-AKTKKPFKIIVTIIITFFLCWC 274
Cdd:cd14989  152 ------------VREIQWLEVTL-----GFIIPFSIIGLCYSLIVRVLVRaqkhRRLrPRRQKALRMILVVVLVFFICWL 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 275 PYHTLNLLELHHTAMPGSV---------FSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd14989  215 PENVFISIQLLQGTQEPSEsydesfrhnHPLTGHIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
42-325 8.07e-14

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 71.39  E-value: 8.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15981    2 MFILAYLFIFLLCMVGNGLVcFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTA--NLHGKISCFNNFSLSTP 198
Cdd:cd15981   82 MSVSASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTreEHHFMVDDYNNSYPLYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPtHSQMdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKL---------------QRNRLAKTK-KPFKII 262
Cdd:cd15981  160 CWEAWP-DTEM-------RKIYTTVLFSHIYLAPLTLIVIMYARIAFKLfkssapirgsqgeeeEGRRVSKRKiKVINML 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 263 VTIIITFFLCWCPYHTLNLL---------ELHhtAMPGSVFslglPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15981  232 IIVALFFTLSWLPLWTLMLLtdyghlsedQLN--LVTVYVF----PFAHWLAFFNSSVNPIIYGYFNENFRR 297
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-324 8.32e-14

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 70.81  E-value: 8.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15052    9 LLVIATIGGNILVCLaISLEKRLQNVTNYFLMSLAIADLLVGLLvMPLSILTELFGGVWPLPLVLCLLWVTLDVLFCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF--RDTANLHGKISCfnnfslstpgssswp 204
Cdd:cd15052   89 IMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLgiIDTTNVLNNGTC--------------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 205 thsqmdpVGYSRHMVVTVTrfLCGFLVPVLIITACY-LTIvcKLQRNRlaktKKPFKIIVTIIITFFLCWCPYHTLNLL- 282
Cdd:cd15052  154 -------VLFNPNFVIYGS--IVAFFIPLLIMVVTYaLTI--RLLSNE----QKASKVLGIVFAVFVICWCPFFITNILt 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 283 ---ELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15052  219 glcEECNCRISPWLLSVFV----WLGYVSSTINPIIYTIFNKTFR 259
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
44-324 9.85e-14

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 70.67  E-value: 9.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVLIRnKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdtanlhGKISCFNNFSLSTPGSSS 202
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIY-------SNLVPFTRINNSTGNMCR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 --WPThsqmDPVGYSRHMVVtvtrFLCGFLVPVLIITACYLTIVCKLQR--NRLAKTKKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15978  157 llWPN----DVTQQSWYIFL----LLILFLIPGIVMMTAYGLISLELYRgiKFLMAKKRVIRMLIVIVILFFLCWTPIFS 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 279 LNLLELHHTAMPGSVFSlGLPLA--TALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15978  229 ANAWRAFDTRSADRLLS-GAPISfiHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
43-176 1.14e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 70.49  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15148    3 LAVFYSLIFLFGLVGNLLALWVFLFiHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYM 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 122 NMFTSVFLLTIISSDRCI----SVLLPVWSQNHRSVrlayMACMVIWVLAFFLSSPSLV 176
Cdd:cd15148   83 NMYISIILLGFISLDRYLkinrSSRRQKFLTRKWSI----VACGVLWAVALVGFVPMIV 137
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
41-325 1.61e-13

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 69.60  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNgLVIIIATFKMKK--TVNMVWFLNLAVADFLFNVF-LPIhityAAMDY---HWVFGTAMCKI 114
Cdd:cd15210    1 YFAAVWGIVFMVVGVPGN-LLTVLALLRSKKlrTRTNAFIINLSISDLLFCAFnLPL----AASTFlhqAWIHGETLCRV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 115 SNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlHGKISCFNnFS 194
Cdd:cd15210   76 FPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLW--------LGIWGRFG-LD 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 LSTPGSSSWPTHSQMDPvgysrhmvvTVTRFLCGFLVPVLIITACYLtivcklqrnrLAKTKKPFKIIVTIIITFFLCWC 274
Cdd:cd15210  147 PKVCSCSILRDKKGRSP---------KTFLFVFGFVLPCLVIIICYA----------RREDRRLTRMMLVIFLCFLVCYL 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 275 PYHTLNLLelhHTAMPGSVFSLglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15210  208 PITLVNVF---DDEVAPPVLHI---IAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
41-325 1.93e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 69.89  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFL-PIHITYaAMDYHWVFGTAMCKISNFL 118
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIIsISHFKQLHTPTNLLLLSLAVADFLVGLLVmPFSMIR-SIETCWYFGDTFCKLHSSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFR-DTANLHGKISCFNNFSLST 197
Cdd:cd15055   80 DYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNlNQPGLIRYNSCYGECVVVV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTI--VCKLQ----------------RNRLAKTK--K 257
Cdd:cd15055  160 --NFIW-----------------GVVDLVLTFILPCTVMIVLYMRIfvVARSQarairshtaqvslegsSKKVSKKSerK 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 258 PFKIIVTIIITFFLCWCPYHTLNLLELhHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15055  221 AAKTLGIVVGVFLLCWLPYYIVSLVDP-YISTPSSVFD----VLIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
41-325 2.37e-13

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 69.27  E-value: 2.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMKK---TVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKIsn 116
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVIL--SFRVNRqlrTVNNYFLLSLACADLIIGLVsMNLYTVYLVMGY-WPLGPLLCDL-- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFT--SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF-------RDTANlhgkI 187
Cdd:cd15049   76 WLALDYVASnaSVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGwqyfvgeRTVPD----G 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 188 SCFNNFsLSTPgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYltivCKLQRNrLAKTKKPFKIIVTIII 267
Cdd:cd15049  152 QCYIQF-LDDP--------------------AITFGTAIAAFYLPVLVMTILY----WRIYRE-TARERKAARTLSAILL 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 268 TFFLCWCPYHTLNLLE-LHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15049  206 AFIITWTPYNILVLVStFCAKCIPDTLWSFGY----WLCYINSTINPFCYALCNKTFRK 260
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 2.63e-13

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 69.49  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIwIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNfslstpgsssW 203
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPF--KPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVA----------W 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 PthsqmDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR-------------NRLAKTKKPFKIIVTIIITFF 270
Cdd:cd16004  153 P-----GDSGGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRsavpghqahgayhRQLQAKKKFVKTMVVVVVTFA 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFK 324
Cdd:cd16004  228 ICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIFwLAMSSTMYNPIIYCCLNQRFR 282
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
45-325 2.70e-13

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 69.61  E-value: 2.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIAtFKMKKTVNMVWFL--NLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVL-YRRRSKLKPAELLtvNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSqNHRSVRLAYMACMVIWVLAFFLSSPSLV--FRDTANLHGkISCFNNFSLSTPGS 200
Cdd:cd15074   84 GCCSINTLTAISIYRYLKICHPPYG-PKLSRRHVCIVIVAIWLYALFWAVAPLVgwGSYGPEPFG-TSCSIDWTGASASV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SswpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKT---KKPFKIIVTIIITFFLC----- 272
Cdd:cd15074  162 G---------------GMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAgfdSRSKRQHKIERKVTKVAvlica 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 273 -----WCPYHTLNLLELHhtAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15074  227 gfliaWTPYAVVSMWSAF--GSPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
41-333 3.31e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 69.21  E-value: 3.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMK---KTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKIsn 116
Cdd:cd15299    4 VLIAFLTGILALVTIIGNILVIV--SFKVNkqlKTVNNYFLLSLACADLIIGVIsMNLFTTYIIMN-RWALGNLACDL-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFT--SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanLHGKIS-----C 189
Cdd:cd15299   79 WLSIDYVASnaSVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQY--FVGKRTvppdeC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 190 FNNFsLSTPgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVcklqrNRLAKTKKPFKIIVTIIITF 269
Cdd:cd15299  157 FIQF-LSEP--------------------IITFGTAIAAFYLPVTIMTILYWRIY-----KETIKEKKAAQTLSAILLAF 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 270 FLCWCPYHTLNLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK-FKVALFSR 333
Cdd:cd15299  211 IITWTPYNIMVLVNTFcDSCIPKTYWNLGY----WLCYINSTVNPVCYALCNKTFRTtFKMLLLCQ 272
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
45-282 4.15e-13

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 69.02  E-value: 4.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15367    5 VVYILVLVVGLPANCLSLYYGYLQIKAKNELgIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIW-----VLAFFLSSPSLvfrdTANLHGKISCFNNFslstp 198
Cdd:cd15367   85 YISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWlkelmTCVFFFLHGEI----SKDKENHSVCFEHY----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswPTHSQMDPVGYsrhmvvtvTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPF---KIIVTIIITFFLCWCP 275
Cdd:cd15367  156 -----PIKAWEHNINY--------YRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIqikRLVLSTVVIFLVCFGP 222

                 ....*..
gi 215272319 276 YHTLNLL 282
Cdd:cd15367  223 YHILLLV 229
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
41-325 5.21e-13

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 68.45  E-value: 5.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVsIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtanlhgkiscFNNFSLSTPG 199
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQ----------FIVGGRTVPE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsqmdpVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNrlaktKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15297  151 GECY--------IQFFSNAAVTFGTAIAAFYLPVIIMTVLYWQISRASSRE-----KKVTRTILAILLAFIITWTPYNVM 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 280 NLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15297  218 VLINTFcASCIPNTVWTIGY----WLCYINSTINPACYALCNATFKK 260
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
47-326 6.08e-13

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 68.32  E-value: 6.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  47 YSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmdYHWVFGTAMCKI----SNFLLIH 121
Cdd:cd15171    7 CSAVFLVGLLDNGLVVfILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAW--HGGSLGNPTCKVlvalSSVGLHS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVfLLTIISSDRCISVLLpvWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSS 201
Cdd:cd15171   85 EALFNV-LLTVQASRVFFHGRL--ASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAEE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVcKLQRNRLAKTKKpFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15171  162 TFWKY------------FLTLKMNIVVLVFPLLVFIICCVQLR-KTQRFRERQRDL-SKLVFAIMVVFLLMWAPYNIALF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 282 LELHHTAMP----GSVFSL--GLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15171  228 LSAFKEHFSlrdcKSSYHLdaSVQVTKLIATTHCCVNPLLYALLDPAFRRR 278
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
42-325 7.39e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 67.69  E-value: 7.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15310    2 YYALSYCALILAIVFGNVLVCMaVLRERALQTTTNYLVVSLAVADLLVaTLVMPWVVYLEVTGGVWNFSRICCDVFVTLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQ---NHRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlhgkiscfnnFSLS 196
Cdd:cd15310   82 VMMCTASILNLCAISIDRYTAVVMPVHYQhgtGQSSCRRVSLMITAVWVLAFAVSCPLL-----------------FGFN 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSWPTHSQMDPVGYSrhmvvTVTRFLCGFLVPVLIITACYLTivcklqrnrLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15310  145 TTGDPTVCSISNPDFVIYS-----SVVSFYLPFGVTLLVYVRIYVV---------LLREKKATQMLAIVLGAFIVCWLPF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 277 HTLNLLELHHTA--MPGSVFSLglplATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15310  211 FLTHILNTHCQAchVPPELYSA----TTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
41-324 7.39e-13

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 68.03  E-value: 7.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMVwFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNF 117
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIaaICTTKKLHQPANYL-ICSLAVTDFLVAVLvMPLSITYIVMD-TWTLGYFICEIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFnnfslst 197
Cdd:cd15335   79 VDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCI------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpthSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15335  152 ---------IQHDHVIY------TIYSTFGAFYIPLTLILILYYRIYHAASRER-----KAARILGLILGAFILSWLPFF 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 278 TLNLLELHHTAMPGSVFSLGLplaTALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15335  212 IKELIVGLSVMTVSPEVADFL---TWLGYVNSLVNPLLYTSFNEDFK 255
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
44-324 7.53e-13

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 67.91  E-value: 7.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLG---ILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15063    1 LISLLVLTFLNvlvVLGNLLVIAaVLCSRKLRTVTNLFIVSLACADLLVGtLVLPFSAVNEVLDV-WIFGHTWCQIWLAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdTANLHGKISCFNNFSLSTP 198
Cdd:cd15063   80 DVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV---GWNDGKDGIMDYSGSSSLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSwPTHSQmdpvGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVcklqrnRLAKT-KKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15063  157 CTCE-LTNGR----GY------VIYSALGSFYIPMLVMLFFYFRIY------RAARMeTKAAKTVAIIVGCFIFCWLPFF 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 278 TLNLLE-LHHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15063  220 TVYLVRaFCEDCIPPLLFS----VFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
41-257 8.72e-13

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 67.84  E-value: 8.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIAT--FKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd14983    1 QLSLMVYVLTILLGLPSNLLALYAFVnrARLRLTPNVIYMINLCLSDLVFILSLPIKIVEALSS-AWTLPAVLCPLYNLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFF-------LSSPSLVFRDTANLHGKISCFN 191
Cdd:cd14983   80 HFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFhvtlvfiLETSGGTLDINTPVGNSSTCYE 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 192 NFslstpgssswpTHSQMDPVGYSRHMVVTVTRFLcgflvPVLIITACYLTIVCKLQRNRLAKTKK 257
Cdd:cd14983  160 NF-----------TPEQLALLAPVRLELSLVLFFL-----PLAITAFCYVRCIRILVRSRLHERRK 209
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-324 1.42e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 67.58  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15357    3 MSLVYAVIFVVGVIGNLLVcLVILKHQNMKTPTNYYLFSLAVSDLLVLLFgMPLEVYEMWSNYPFLFGPVGCYFKTALFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSlvfrdtANLHG-KISCFNNFSLsTPG 199
Cdd:cd15357   83 TVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPN------TSIHGiKLQYFPNGTL-IPD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMdpvgYSRHMVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNRLAKT------------KKPFKIIVTIII 267
Cdd:cd15357  156 SATCTVVKPL----WIYNLIIQITSLLF-YVLPMGVISVLYYLMGLKLRGDKSLEAdemnvniqrpsrKSVTKMLFVLVL 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 268 TFFLCWCPYHTLNL---LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15357  231 VFAICWAPFHVDRLffsFVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
41-324 1.44e-12

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 67.12  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFLPIHITYaamdyhwVFGTAMCKISNFLL 119
Cdd:cd15163    1 LALMVINTLIFLVGIVLNSLALYVFCFRTKtKTTSVIYTINLVVTDLLVGLSLPTRIVM-------YYSAGNCLTCSFVH 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IH----NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdTANLHGKISCFNNFSL 195
Cdd:cd15163   74 IFsyfvNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILT---TAIKFASCCLSKLFAL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 StpgssswpthsqmdpvgysrhmvvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRL-----AKTKKPFKIIVTIIITFF 270
Cdd:cd15163  151 T-----------------------------VFEFFLPLLIITFFTIRIMCALSRPGLmhqsrERRMRAVQLLITVLIIFM 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15163  202 ICFTPFHVRQVAVAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
42-325 1.59e-12

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 67.35  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVY-SIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLF---NVFlPIhITYAAMDYHWVFGTAMCKISN 116
Cdd:cd15337    1 YLIGIYiAIVGILGVIGNLLVIYLfSKTKSLRTPSNMFIINLAISDFGFsavNGF-PL-KTISSFNKKWIWGKVACELYG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCFNNFsL 195
Cdd:cd15337   79 FAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGfQTSCTFDY-L 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STpgssSWPTHSqmdpvgYSRHMvvtvtrFLCGFLVPVLIITACYLTIVCKLQRNRL------------------AKTKK 257
Cdd:cd15337  158 SR----DLNNRL------FILGL------FIFGFLCPLLIIIFCYVNIIRAVRNHEKemtqtaksgmgkdtekndARKKA 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 258 PF---KIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15337  222 EIriaKVAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPV--MFAKASAIYNPIIYALSHPKFRA 290
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
41-258 1.62e-12

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 67.12  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15199    1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVwKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscfnnfslstpg 199
Cdd:cd15199   81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKN----------------- 143
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 200 SSSWPTHSQMDPVGYSRHMVVTVtrFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKP 258
Cdd:cd15199  144 FTECNSFSPKDDEDFSDTWQEAV--FFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQP 200
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
41-325 1.75e-12

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 66.97  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMK---KTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISN 116
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMI--SFKVNsqlKTVNNYYLLSLACADLIIGIFsMNLYTSYILMG-YWALGSLACDLWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkisCFNNFSls 196
Cdd:cd15300   78 ALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIL------------CWQYFV-- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpGSSSWPTHSQMdpVGYSRHMVVTVTRFLCGFLVPVLIITACYltivCKLQRNRLaKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15300  144 --GKRTVPERECQ--IQFLSEPTITFGTAIAAFYIPVSVMTILY----CRIYKETI-KERKAAQTLSAILLAFIITWTPY 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 HTLNLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15300  215 NIMVLVSTFcSDCIPLTLWHLGY----WLCYVNSTVNPMCYALCNKTFRK 260
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
41-325 1.86e-12

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 67.13  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVFLPIHITYaamdYHWVFGTAMCKISNFLL 119
Cdd:cd15920    1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSIsVYMRNLALADLLLVLCLPFRVAY----QNTAGPLSFCKIVGAFF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPslvfrdtanlhgkiSCFNNFSLSTPG 199
Cdd:cd15920   77 YLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIP--------------FLFESRNEGPCD 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLAKT--------KKPFKIIVTIIITFFL 271
Cdd:cd15920  143 NKCFHFRSKGLTAGGINLTAVVI------FYILSLLFLYFYAKISHKLYKVSLGNAqqqikkasKRAIIKTFIVLAIFIV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 272 CWCPYH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15920  217 CFVPYHivrvpyVLAQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
45-325 1.92e-12

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 66.87  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFL---GILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYhWVFGTAMCKIsnFLL 119
Cdd:cd15321    8 AIAAAITFLilfTIFGNVLVIIaVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFSLANELMGY-WYFRKTWCEI--YLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMF--TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscfnnfslST 197
Cdd:cd15321   85 LDVLFctSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGK---------------QK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVcKLQRNRlaktKKPFKIIVTIII-TFFLCWCPY 276
Cdd:cd15321  150 DEQGGLPQCKLNEEAWY------ILSSSIGSFFAPCLIMILVYLRIY-LIAKNR----EKRFTFVLAVVIgVFVLCWFPF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 277 ---HTLNLLELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15321  219 ffsYSLGAICPELCKVPHSLFQFFF----WIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-318 2.22e-12

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 66.76  E-value: 2.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVF--LP-----IHITYAAMDYhwvfgtaMCKIS 115
Cdd:cd15387    4 VTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMkHLSIADLVVAVFqvLPqliwdITFRFYGPDF-------LCRLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 116 NFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRlayMACMVIWVLAFFLSSPSL---VFRDTANlhGKISCFNN 192
Cdd:cd15387   77 KYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDR---VYVLFSWLLSLVFSIPQVhifSLREVGN--GVYDCWAD 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 193 FSLstpgssSWpthsqmDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLAKTKK--------------- 257
Cdd:cd15387  152 FIQ------PW------GPKAYITWITLSV------YIIPVLILSVCYGLISFKIWQNVKLKTRRetktplssaasggaa 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 258 ----------------PFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSlgLPLATALAIANSCMNPILYVF 318
Cdd:cd15387  214 larvssvkliskakirTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEASP--FIIAMLLASLNSCCNPWIYMF 288
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
39-171 6.14e-12

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 65.50  E-value: 6.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  39 TRIFLVVVYSIVcflGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFgTAMCKISNFL 118
Cdd:cd15107    2 TMNFLSIIIALV---GLAGNAIVLWLLGFHMHRNAFSVYILNLAGADFLFLCTQIVFSLEIVLQFHSID-IHIPLFLLTV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS 171
Cdd:cd15107   78 TMFAYLAGLSMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLS 130
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
41-325 7.05e-12

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 64.97  E-value: 7.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMVwFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKISNF 117
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVItaIIVTRKLHHPANYL-ICSLAVTDFLVAVLvMPFSIMYI-VKETWIMGQVVCDIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAnlhgkiscfnnfslst 197
Cdd:cd15334   79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQT---------------- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTkkpfkIIVTIIITFFLCWCPYH 277
Cdd:cd15334  143 -------TSREDECIIKHDHIVFTIYSTFGAFYIPLALILILYYKIYRAATRERKAAT-----TLGLILGAFVICWLPFF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 278 T----LNLLELHHTAMPGSVFslglplATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15334  211 VkeviVNTCDSCYISEEMSNF------LTWLGYINSLINPLIYTIFNEDFKK 256
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
41-325 7.41e-12

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 65.04  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLsIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRD---TANLHGKISCFNNFsLS 196
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQfvvGKRTVPDNQCFIQF-LS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGssswpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYLTIVCKlqrnrLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15298  160 NPA--------------------VTFGTAIAAFYLPVVIMTVLYIHISLA-----SARERKVTRTIFAILLAFILTWTPY 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 HTLNLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15298  215 NVMVLVNTFcQSCIPDTVWSIGY----WLCYVNSTINPACYALCNATFKK 260
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
41-316 7.60e-12

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 65.08  E-value: 7.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFK--MKKTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKpaMRSAINLL-LANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAML 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRcisVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnnfslsTP 198
Cdd:cd15213   80 YWFFVLEGVAILLIISVDR---YLIIVQRQDKLNPHRAKILIAVSWVLSFCVSFPPLV--------------------GW 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSR---HMVVTVTRFLCGFLVPVLIITACYLtivCKLQRNRLAKTKKpFKIIVTIIITFFLCWCP 275
Cdd:cd15213  137 GKYEFPPRAPQCVLGYTEspaDRIYVVLLLVAVFFIPFLIMLYSYF---CILNTVRSFKTRA-FTTILILFIGFSVCWLP 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 215272319 276 YHTLNLleLHHTAMPGSVFSLGLPLATALAIANSCMNPILY 316
Cdd:cd15213  213 YTVYSL--LSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
41-326 9.35e-12

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 65.05  E-value: 9.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLaVAVNRRLRNLTNYFIVSLAVTDLLLGLLvLPFSAIYELRG-EWPLGPVFCNIYISL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTANLHGKiscfnnfSLST 197
Cdd:cd15051   80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWNTPDGRVQ-------NGDT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPThsqmdpvgySRHMVVTVTrfLCGFLVPVLIITACYLTI--VCKLQRNRLAKTKKPFKIIVTIIITFF----- 270
Cdd:cd15051  153 PNQCRFEL---------NPPYVLLVA--IGTFYLPLLIMCGVYLRIfrIAREQAKRINALTPASTANSSKSAATArehka 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 271 ------------LCWCPYHTLnllelhHTAMPGS---VFSLGLPLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15051  222 tvtlaavlgafiICWFPYFTY------FTYRGLCgdnINETALSVVLWLGYANSALNPILYAFLNRDFRRA 286
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
42-325 1.54e-11

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 64.16  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIhitYAAMDYH-----------WVFGT 109
Cdd:cd15136    2 WLRIGVWFVFLLALVGNIIVLLvLLTSRTKLTVPRFLMCNLAFADFCMGIYLGL---LAIVDAKtlgeyynyaidWQTGA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 110 AmCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgKISC 189
Cdd:cd15136   79 G-CKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLV---------GVSS 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 190 FNNFSLSTPGSSSWPTHsqmdpVGYsrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPF---KIIVTII 266
Cdd:cd15136  149 YSKTSICLPFETETPVS-----KAY-------VIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNDTriaKRMALLV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 267 ITFFLCWCPyhtlnllelhhTAMPGSVFSLGLPL-----ATALAI----ANSCMNPILYVFMGQDFKK 325
Cdd:cd15136  217 FTDFLCWAP-----------IAFFGLTAAFGLPLisvsnAKILLVffypLNSCANPFLYAIFTKQFRR 273
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
41-324 1.60e-11

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 63.94  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIA-TFKMKKTVNMVWFLNLAVAD--FLFNVFLPIHITYAAMDYHWVFGTAMCKISNF 117
Cdd:cd14995    1 VVATFLVLLICGVGIVGNIMVVLVVlRTRHMRTPTNCYLVSLAVADlmVLVAAGLPNEIESLLGPDSWIYGYAGCLLITY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLH--GKISCFNNFSL 195
Cdd:cd14995   81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHygDDIVVRCGYKV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STpgssswpthsqmdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktKKPFKIIVTIIITFFLCWCP 275
Cdd:cd14995  161 SR-----------------HYYLPIYLADFVLFYVIPLLLAIVLYGLIGRILFSSR----KQVTKMLAVVVVLFALLWMP 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 276 YHTLnlLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd14995  220 YRTL--VVYNSFASPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFR 266
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
45-330 1.71e-11

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 64.05  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGL-VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15928    5 AVCSVLMLVGASGNLLtVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSsw 203
Cdd:cd15928   85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSS-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 pthsqmdpvGYSRHMVVTVTRFlcgFLVPVLIITACYLTIVCKL----QRNRLAKT-------KKPFKIIVTIIITFFLC 272
Cdd:cd15928  163 ---------GLLSVMLWVSTSF---FFVPMVCLSLLYGLIGRALwdrrQRSRTAGAsrrdnnhRQTVRMLAVIVLAFVLC 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 273 WCPYHTLNLLELH------HTAMPGSVFSLglpLATALAIANSCMNPILYVFMGqdfKKFKVAL 330
Cdd:cd15928  231 WLPFHVGRVIFNHsrastkHLHYVSQYFNL---VSFVLFYLSAAINPILYNLMS---KRYRYAV 288
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-325 2.92e-11

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 63.28  E-value: 2.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILsVACNRHLRTPTHYFIVNLAVADLLLSfTVLPFSATLEVLGY-WAFGRIFCDVWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDtanlhgkiscfnnfslst 197
Cdd:cd15062   80 DVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISiGPLLGWKE------------------ 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYltivCKLQRN--RLAKTKKPFKIIVTIIITFFLCWCP 275
Cdd:cd15062  142 ------PAPADEQACGVNEEPGYVLFSSLGSFYLPLAIILVMY----CRVYVVafKFSREKKAAKTLGIVVGAFVLCWFP 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 276 YhtlnllelhHTAMP-GSVFSLGLPLATALAIA------NSCMNPILYVFMGQDFKK 325
Cdd:cd15062  212 F---------FVVLPlGSLFSTLKPPEPVFKVVfwlgyfNSCLNPIIYPCSSREFKR 259
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
41-325 4.67e-11

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 62.45  E-value: 4.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFL 118
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILsVFTYRPLRIVQNFFIVSLAVADLAVAIFvLPLNVAYFLLG-KWLFGIHLCQMWLTC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnnfslstp 198
Cdd:cd15060   80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI---------------------- 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMD-PVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLqrnrlAKTKKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15060  138 GWNDWPENFTETtPCTLTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFIAT-----SKERRAARTLGIIMGVFVVCWLPFF 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 278 TLN-LLELHHTAMPGSVFSLGLplaTALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15060  213 LMYvILPFCETCSPSAKVVNFI---TWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
41-325 5.51e-11

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 62.36  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLViIIATF---KMKKTVNmvWFL-NLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKIS 115
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLV-IVAVLtsrKLRAPQN--WFLvSLAVADILVGLLiMPFSLVNELMGY-WYFGSVWCEIW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 116 NFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV--FRDTANLHGKISCfnnf 193
Cdd:cd15059   77 LALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFgwKDEQPWHGAEPQC---- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 SLStpgssswpthsqmDPVGYsrhmvvTVTRFLCGFLVPVLIITACYltivCKLQRNRLAKTKKPFKIIVTIIITFFLCW 273
Cdd:cd15059  153 ELS-------------DDPGY------VLFSSIGSFYIPLLIMIIVY----ARIYRAAKRKERRFTLVLGVVMGAFVLCW 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 274 CPYHTLNLLEL--HHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15059  210 LPFFFTYPLVVvcKTCGVPELLFK----FFFWLGYCNSALNPVIYTIFNKDFRR 259
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-325 7.11e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 62.27  E-value: 7.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFK-MKKTVNMVwFLNLAVAD--FLFNVFLPIHITYAAMDYHWVFGTAM---CKI 114
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVLTRKsMRSSTNVY-LAALAVSDilVLLSALPLFLLPYIADYSSSFLSYFYayfLPY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 115 SNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkISCFNNfs 194
Cdd:cd14978   80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEV------VECENC-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 lstpgssSWPTHSQMDPVGYSRHM-----VVTVTRFLCGFLVPVLIITACYLTIVCKLQR-NRLAKTKKPFKIIVTIIIT 268
Cdd:cd14978  152 -------NNNSYYYVIPTLLRQNEtyllkYYFWLYAIFVVLLPFILLLILNILLIRALRKsKKRRRLLRRRRRLLSRSQR 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 269 FF---------------LCWCPYHTLNLLE-LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14978  225 RErrttimliavvivflICNLPAGILNILEaIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-318 1.06e-10

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 62.15  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVF--LP---IHITYAAMDYHWvfgtaMCKISNF 117
Cdd:cd15385    4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIkHLSLADLVVAFFqvLPqlcWDITYRFYGPDF-----LCRIVKH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQnHRSVRLAYMACMVIWVLAFFLSSP-SLVF--RDTANLHGKISCFNNFS 194
Cdd:cd15385   79 LQVLGMFASTYMLVMMTADRYIAICHPLKTL-QQPTKRSYLMIGSAWALSFILSTPqYFIFslSEIENGSGVYDCWANFI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 LstpgssSWPTHSqmdpvgYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLAKTK------------------ 256
Cdd:cd15385  158 V------PWGIKA------YITWITISI------FVVPVIILLTCYGFICYNIWRNIKCKTRrglsdnalknillavcvs 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 257 ----------KPFKIIVTIIITFFLCWCPYHTLNLLEL--HHTAMPGSVfSLGLPLATALAIANSCMNPILYVF 318
Cdd:cd15385  220 svktisrakiRTVKMTFVIVLAYIVCWAPFFTIQMWSVwdQNFPWDESE-NTAVTITALLASLNSCCNPWIYMF 292
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
50-325 1.22e-10

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 61.67  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  50 VCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVF 128
Cdd:cd15000    9 VVLFGIFGNFVLLyILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 129 LLTIISSDRCISVLLPvwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-----ANLHGKIsCFNNFSLStpgSSSW 203
Cdd:cd15000   89 ALCAVSYDRLTAIVLP--SEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYrerqwKNFLETY-CAENTQVL---PIYW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 pthsqmdpvgysrHMVVTVTRFLcgflvPVLIITACYLTIVCKLQR-----------NRLAKTKKPFKIIVTIIITFFLC 272
Cdd:cd15000  163 -------------HVIITVLVWL-----PLGIMLICYSAIFWKLDKyerrvlrrehpSVVRYKKKAAKTLFIVLITFVVC 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 273 WCPYHTL------NLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15000  225 RIPFTALifyrykLVPNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-325 1.24e-10

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 61.46  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVcfLGILGNgLVIIIATFKMKKTVNM--VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15402    6 ILIFTIV--VDILGN-LLVILSVYRNKKLRNAgnIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvFRDTANLHGKI-SCfnnfSLSTPGS 200
Cdd:cd15402   83 SVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNL-FVGSLQYDPRIySC----TFAQSVS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTI-VCKLQ-RNRLAKTKKP---------FKIIVTIIITF 269
Cdd:cd15402  158 SAY-----------------TIAVVFFHFILPIIIVTFCYLRIwILVIQvRRRVKPDNKPklkphdfrnFVTMFVVFVLF 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 270 FLCWCPyhtLNLLELHHTAMPGSVFSLgLP-----LATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15402  221 AVCWAP---LNFIGLAVAVDPETIVPR-IPewlfvASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
49-324 1.51e-10

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 61.46  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIiATFKMKKTVN-MVWFL-NLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15081   21 FVVFASVFTNGLVLV-ATLKFKKLRHpLNWILvNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCFNN-FSlstpGSSSWP 204
Cdd:cd15081  100 LWSLTIISWERWVVVCKPFGNIKFDG-KLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGlKTSCGPDvFS----GSSDPG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 205 THSQMdpvgysrhMVVTVTrflCGFLvPVLIITACYLTI------VCKLQRNRLAKTK---KPFKIIVTIIITFFLCWCP 275
Cdd:cd15081  175 VQSYM--------IVLMIT---CCII-PLAIIILCYLQVwlairaVAQQQKESESTQKaekEVSRMVVVMIFAYCFCWGP 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 276 YhtlNLLELHHTAMPGSVFSlglPLATAL----AIANSCMNPILYVFMGQDFK 324
Cdd:cd15081  243 Y---TFFACFAAANPGYAFH---PLAAALpayfAKSATIYNPIIYVFMNRQFR 289
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
53-325 2.01e-10

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 60.68  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  53 LGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDYhWVFGTAMCKISNFLLIHNMFTSVFLL 130
Cdd:cd15326   13 FAIVGNILVILsVVCNRHLRIPTNYFIVNLAIADLLLSfTVLPFSATLEILGY-WVFGRIFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 131 TIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTANLHGKIScfnnfslstpGSSSWPTHSQM 209
Cdd:cd15326   92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISiGPLLGWKEPAPPDDKVC----------EITEEPFYALF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 210 DPVGysrhmvvtvtrflcGFLVPVLIITACYLTIVckLQRNRLAKTKKPFKIIVTIIITFFLCWCPYhtlnllelhHTAM 289
Cdd:cd15326  162 SSLG--------------SFYIPLIVILVMYCRVY--IVALKFSREKKAAKTLGIVVGMFILCWLPF---------FIAL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 290 P-GSVFSLGLPLATALAIA------NSCMNPILYVFMGQDFKK 325
Cdd:cd15326  217 PlGSLFSHLKPPETLFKIIfwlgyfNSCLNPIIYPCSSKEFKR 259
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
41-325 3.59e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 60.22  E-value: 3.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMKK---TVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGTAMCKISN 116
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMI--SFKIDKqlqTISNYFLFSLAVADFAIGVIsMPLFTVYTALGY-WPLGYEVCDTWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrDTANLHGKIS-----CFN 191
Cdd:cd15301   78 AIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIY--SWPYIEGKRTvpagtCYI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 192 NFSLSTPgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFL 271
Cdd:cd15301  156 QFLETNP--------------------YVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIV 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 272 CWCPYHTLNLLElHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15301  216 TWTPYNVLVLIK-AFFPCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 4.24e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 60.24  E-value: 4.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTcLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKIscfnnfslstPGSSs 202
Cdd:cd15133   85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGV----------PASA- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpTHSQMDPVgYSRHMVVTVTRFlCGFLVPVLIITACYLTIVCKLQRNRL---------------AKTKKPF------KI 261
Cdd:cd15133  154 --QCTVRKPQ-AIYNMIPQHTGH-LFFVLPMAVISVLYLLMALRLARERGldatgagskigtrtgQLLQHPRtraqvtKM 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 262 IVTIIITFFLCWCPYHTLNLL---ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15133  230 LFILVVVFAICWAPFHIDRLMwsfISDWTDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-325 5.24e-10

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 59.78  E-value: 5.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTcIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLELYEMWSNYPFLLGAGGCYFKTLLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLP-----VWSQNHrsvrlAYMACMVIWVLAFFLSSPSlvfrdtANLHGKiscfnnFSLST 197
Cdd:cd15358   85 CFASILNVTALSVERYIAVVHPlkakyVVTRTH-----AKRVIGAVWVVSILCSIPN------TSLHGI------FQLTV 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHSQMDPVG--YSRHMVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNRL-----AKTKKPF----------- 259
Cdd:cd15358  148 PCRGPVPDSATCMLVKprWMYNLIIQITTLLF-FFLPMGTISVLYLLIGLQLKREKMllvleAKGSKAGdsyqhrriqqe 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 260 --------KIIVTIIITFFLCWCPYHTLNL---LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15358  227 krrrrqvtKMLFVLVVVFGICWAPFHTDRLmwsFISQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
41-325 5.33e-10

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 59.79  E-value: 5.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVcfLGILGNGLVIIiATFKMKKTVNM--VWFLNLAVADFLFNVFlPIHITYAAMDYH-WVFGTAMCKISNF 117
Cdd:cd15209    3 LACVLIVTIV--VDVLGNLLVIL-SVLRNKKLRNAgnIFVVSLSVADLVVAIY-PYPLILHAIFHNgWTLGQLHCQASGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvFRDTANLHGKI-SCFNNFSLS 196
Cdd:cd15209   79 IMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNF-FIGSLQYDPRIySCTFAQTVS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TpgssswpthsqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTI-VCKLQ-RNRLAKTKKP---------FKIIVTI 265
Cdd:cd15209  158 T---------------------VYTITVVVIHFLLPLLIVSFCYLRIwVLVLQvRQRVKPDQRPklkpadvrnFLTMFVV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 266 IITFFLCWCPYHTLNLL-ELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15209  217 FVLFAVCWAPLNFIGLAvAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
42-316 5.62e-10

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 59.51  E-value: 5.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHItYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIyIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFI-YNSFYEGWALGPLGCQIYAFLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdtanlhgkisCFNNFS----LS 196
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPL-NGNPLTRGKALLLILFIWLYALPWALLPLLF-----------GWGRYVpegfLT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPG----SSSWPTHSQMdpvgysrhmvvtVTRFLCGFLVPVLIITACYLTIVC-------------------KLQRNRLA 253
Cdd:cd15079  149 SCSfdylTRDWNTRSFV------------ATIFVFAYVIPLIIIIYCYSFIVKavfahekalreqakkmnvvSLRSNADA 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 254 KTK----KPFKIIVTIIITFFLCWCPYHTLNLLelhhtampGSVFSLGL--PLATAL----AIANSCMNPILY 316
Cdd:cd15079  217 NKQsaeiRIAKVALTNVFLWFIAWTPYAVVALI--------GAFGNQSLltPLVSMIpalfAKTAACYNPIVY 281
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
53-329 6.83e-10

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 59.51  E-value: 6.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  53 LGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLT 131
Cdd:cd15131   13 VGVTGNLMTMlVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNIT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 132 IISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiscfNNFSLSTPGSSSWPTHSqmdp 211
Cdd:cd15131   93 ALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGT----NPIDTNECKATEYAVRS---- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 212 vGYSRHMVVTVTRFlcgFLVPVLIITACYLTIVCKLQRN-----------RLAKTKKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15131  165 -GLLTIMVWVSSVF---FFLPVFCLTVLYSLIGRKLWRRrrenigpnashRDKNNRQTVKMLAVVVFAFVLCWLPFHVGR 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 281 LLeLHHTAMPGS----VFSLGLPL-ATALAIANSCMNPILYVFMGqdfKKFKVA 329
Cdd:cd15131  241 YL-FSKSFEAGSleiaLISQYCNLvSFVLFYLSAAINPILYNIMS---KKYRVA 290
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
52-324 1.30e-09

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 58.45  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  52 FLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIHNMFTSVFL 129
Cdd:cd15330   12 LCAIFGNACVVAaIALERSLQNVANYLIGSLAVTDLMVSVLvLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTSSILH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 130 LTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnnfSLSTPGSSSWPthsqm 209
Cdd:cd15330   91 LCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML-----------------GWRTPEDRSDP----- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 210 DPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVcklqrNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLelhhtaM 289
Cdd:cd15330  149 DACTISKDPGYTIYSTFGAFYIPLILMLVLYGRIF-----KAAARERKTVKTLGIIMGTFILCWLPFFIVALV------L 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 215272319 290 PGSVFSLGLP-----LATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15330  218 PFCESTCHMPellgaIINWLGYSNSLLNPIIYAYFNKDFQ 257
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
41-325 1.57e-09

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 58.29  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIaTFKMKKTVNMVWFL-NLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15150    1 VIFPLLYTVLFIVGLTMNGLAMRV-FFQIPSKSNFIIFLkNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKIscFNNFSLSTPG 199
Cdd:cd15150   80 YFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNV--KKCSLLKSEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsqmdpvgysrHMVVTvtrFLCG--FLVPVLIITACYLTIVCKL-------QRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd15150  158 GLVW-------------HEIVN---YICQviFWVNFLIVIVCYTLITKELyksykrtRGVGKVSRKKVNVKVFIIIAVFF 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 271 LCWCPYHTLNL-LELHHT----AMPGSVFSLGLPLATA-LAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15150  222 ICFVPFHFARIpYTLSQTrdvfDCTAKNTLFYVKESTLwLTSLNACLDPFIYFFLCKSFRN 282
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
49-171 1.62e-09

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 58.22  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFnvfLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM--FTS 126
Cdd:cd15105    9 IFGLVGLTGNAIVFWLLGFRLHRNAFSVYILNLALADFLF---LLCHIIDSTLLLLKVFYPNIIFLPCFYTIMMVlyITG 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS 171
Cdd:cd15105   86 LSMLSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLIC 130
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
44-325 2.78e-09

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 57.46  E-value: 2.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYsIVCFLGIL----GNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15317    1 VIIY-IVLVLAMLitvsGNLVVIIsISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF----RDTANLHGKISC----- 189
Cdd:cd15317   80 DLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTgandEGLEEYSSEISCvggcq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 190 --FNNFslstpgsssWpthsqmdpvgysrhmvvTVTRFLCgFLVPVLIITACYLTI--VCKLQRNRL------------- 252
Cdd:cd15317  160 llFNKI---------W-----------------VLLDFLT-FFIPCLIMIGLYAKIflVARRQARKIqnmedkfrsseen 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 253 ------AKTKKPFKIIVTIIITFFLCWCPYHTLNLL-ELHHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15317  213 sskasaSRERKAAKTLAIVMGIFLFCWLPYFIDTIVdEYSNFITPAIVFD----AVIWLGYFNSAFNPFIYAFFYPWFRK 288
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
46-243 3.04e-09

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 57.42  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVI--IIATFKMKKTVNMvWFLNLAVADFLFNVF-LPIHITyAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15336    6 VILIIGITGMLGNALVIyaFCRSKKLRTPANY-FIINLAVSDFLMSLTqSPIFFV-NSLHKRWIFGEKGCELYAFCGALF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCFNNFSLSTPGSS 201
Cdd:cd15336   84 GITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGlLTSCTWDYMTFTPSVR 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 215272319 202 SWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTI 243
Cdd:cd15336  164 AY-----------------TMLLFCFVFFIPLGIIIYCYLFI 188
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
55-325 3.19e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 57.17  E-value: 3.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  55 ILGNgLVIIIATFKMKKTVNM--VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTI 132
Cdd:cd15400   15 ILGN-LLVIISVFRNRKLRNSgnVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 133 ISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvFRDTANLHGKI-SCfnnfSLSTPGSSSWpthsqmdp 211
Cdd:cd15400   94 IAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNF-FVGSLEYDPRIySC----TFVQTASSSY-------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 212 vgysrhmvvTVTRFLCGFLVPVLIITACYLTI-VCKLQRNRLAKTK-----KP-----FKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15400  161 ---------TIAVVVIHFIVPITVVSFCYLRIwVLVIQVRRKVKSEskprlKPsdfrnFLTMFVVFVIFAICWAPLNLIG 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 281 L-LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15400  232 LaVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
44-325 4.59e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 56.88  E-value: 4.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMckISNFLLIh 121
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWaVKLNRALRTVTNYFIVSLAVADILVGALaIPLAILISLGLPTNFHGCLF--MACLVLV- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 nmFT--SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLvfrdtanlhgkisCFNNFSLSTP 198
Cdd:cd14968   81 --LTqsSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGlTPMF-------------GWNNGAPLES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHMVVtVTRFLCgFLVPVLIITACYLTIVCKLQRN---------------RLAKTKKPFKIIV 263
Cdd:cd14968  146 GCGEGGIQCLFEEVIPMDYMVY-FNFFAC-VLVPLLIMLVIYLRIFRVIRKQlrqiesllrsrrsrsTLQKEVKAAKSLA 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 264 TIIITFFLCWCPYHTLNLLELHHTAMPgsVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14968  224 IILFLFALCWLPLHIINCITLFCPECK--VPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
45-325 5.11e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 56.67  E-value: 5.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIII-ATFKMKKT-VNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFllIHN 122
Cdd:cd15086    5 VFLGFILTFGFLNNLLVLVLfCKYKVLRSpINLL-LLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGF--ANS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFL--LTIISSDRCISVLLPVWSQ--NHRSVRLAymaCMVIWVLAFFLSSPSLVFRDTANLHGK-ISCFNNFSLST 197
Cdd:cd15086   82 LFGIVSLisLAVLSYERYCTLLRPTEADvsDYRKAWLG---VGGSWLYSLLWTLPPLLGWSSYGPEGPgTTCSVQWTSRS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQR----NRLAKTKKPFKIIVTIIITFF--- 270
Cdd:cd15086  159 ANSISY-----------------IICLFIFCLLLPFLVMVYCYGRLLYAIKQvgkiNKSTARKREQHVLLMVVTMVIcyl 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 271 LCWCPYHTLNLLELHhtAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15086  222 LCWLPYGVMALLATF--GKPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYR 274
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
45-325 6.14e-09

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 56.33  E-value: 6.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15151    5 VLYTVLFLVGLILNSVAAWIFFHIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFYITMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTAnlhgkiscfnnfslsTPGSSSWP 204
Cdd:cd15151   85 ISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKP---------------ATPISVKK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 205 THSQMDPVGYSRHMVVTvtrFLCGFLV-PVLIITACYLTIVCK-------LQRNRLAKTKKPFKI-IVTIIITFFLCWCP 275
Cdd:cd15151  150 CASLKSPLGLKWHEVVN---YICQFIFwGVFALMVLFYTIISKkvyesykKSRSKDNKASKKTKAkVFIIVAVFFVCFAP 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 276 YH------TLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15151  227 FHfvrvpyTLSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
40-325 6.21e-09

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 56.34  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  40 RIFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMVwFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKISN 116
Cdd:cd15333    4 KISLAVLLALITLATTLSNAFVIatIYLTRKLHTPANYL-IASLAVTDLLVSILvMPISIVYT-VTGTWTLGQVVCDIWL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNfsls 196
Cdd:cd15333   82 SSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVN---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgssswpthsqmdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQrnrlAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15333  158 ------------------TDHILYTVYSTVGAFYIPTLLLIALYGRIYVEAR----ARERKATKTLGIILGAFIVCWLPF 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 277 HTLNLLelhhtaMPGSVFSLGLPLA-----TALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15333  216 FIISLV------LPICKDACWFHLAifdffTWLGYLNSLINPIIYTMSNEDFKQ 263
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
41-325 7.54e-09

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 56.03  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYhWVFGTAMCKISNFL 118
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVaVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGSTWCAFYLAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtanlHGKISCFNNfslstp 198
Cdd:cd15324   80 DVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTK----HDEWECLLN------ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gSSSWpthsqmdpvgysrhmvVTVTRFLCGFLVPVLIITACYltivCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY-- 276
Cdd:cd15324  150 -DETW----------------YILSSCTVSFFAPGLIMILVY----CKIYRVAKMREKRFTFVLAVVMGVFVLCWFPFff 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 -HTLNLLELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15324  209 tYSLHAVCRKRCGIPDALFNLFF----WIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
43-324 7.92e-09

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 55.99  E-value: 7.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGilGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15306    5 LLILMVIIPTIG--GNILVILAVSLEKKLQYATNYFLmSLAVADLLVGLFvMPIALLTILFEAMWPLPLVLCPIWLFLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSlvfrdtanlhgkiscfnnfslstpgs 200
Cdd:cd15306   83 LFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPV-------------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 sswPTHSQMDPVGYSRHM--VVTVTRF--------LCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd15306  137 ---PIKGIETDVDNPNNItcVLTKERFgdfilfgsLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFL 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15306  214 LMWCPFFITNITSVLCDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFR 267
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
41-325 9.35e-09

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 55.90  E-value: 9.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYhWVFGtAMCKISNF 117
Cdd:cd15057    1 IITGCILYLLVLLTLLGNALVIaaVLRFRHLRSKVTNYFIVSLAVSDLLVAILvMPWAAVNEVAGY-WPFG-SFCDVWVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSpslvfrdtanlhgkISCFNNFSLST 197
Cdd:cd15057   79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISF--------------IPVQLGWHRAD 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRN-----------------------RLAK 254
Cdd:cd15057  145 DTSEALALYADPCQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQirriaaleraaqestnpdsslrsSLRR 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 255 TKKPFKIIVTIIITFFLCWCPYHTLNLL-------ELHHTAMPGSVFSLglplATALAIANSCMNPILYVFmGQDFKK 325
Cdd:cd15057  225 ETKALKTLSIIMGVFVCCWLPFFILNCVlpfcdlrTAQFPCVPDTTFIV----FVWLGWANSSLNPIIYAF-NADFRK 297
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
40-318 9.40e-09

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 55.97  E-value: 9.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  40 RIFLVVVYSIVcFLGILGNGLVIIIATFKMKKTVNMVWF-LNLAVADFLFNVFLPI-HITYAAMDYHWVFGTAMCKISNF 117
Cdd:cd15198    1 RTRLIFLGVIL-VAGVAGNTTVLCWLCGGRRRKSRMNFLlLQLALADLLVIGGTALsQIIWELLGDRWMAGDVACRLLKL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMAcmviWVLAFFLSSPSL-VFRDTANlhgkiscfnnfsls 196
Cdd:cd15198   80 LQASARGASANLVVLLALDRHQAIRAPL-GQPLRAWKLAALG----WLLALLLALPQAyVFRVDFP-------------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSWPTHSQMDPVGYSR---HMVVTVT-RFLCGFLVPVLIITACYLTIVCKLQRNR--------------------- 251
Cdd:cd15198  141 DDPASAWPGHTLCRGIFAPLprwHLQVYATyEAVVGFVAPVVILGVCYGRLLLKWWERAnqapgakkpwkkpskshlrat 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 252 ----LAKTK-KPFKIIVTIIITFFLCWCPYHTLNLLelhhtAMPGSVFSLGLPLATAL---AIANSCMNPILYVF 318
Cdd:cd15198  221 apsaLPRAKvKTLKMTLVIALLFVGCSLPYFIAELA-----AAFGSGDWEPEKVAAALgvmAVANSATNPFVFLF 290
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
45-325 1.02e-08

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 55.69  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDYhWVFGTAMCKISNFLLIHN 122
Cdd:cd15327    5 VFLAIFILMAIVGNILVILsVACNRHLQTVTNYFIVNLAIADLLLStTVLPFSATLEVLGF-WAFGRVFCDIWAAVDVLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDtanlhgkiscfnnfslstPGSS 201
Cdd:cd15327   84 CTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISiGPLLGWKE------------------PPPP 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPTHSQMDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVckLQRNRLAKTKKPFKIIVTIIITFFLCWCPYH-TLN 280
Cdd:cd15327  146 DESICSITEEPGYA------LFSSLFSFYLPLMVILVMYFRVY--VVALKFSREKKAAKTLAIVVGVFILCWFPFFfVLP 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 281 LLELHHTAMPG-SVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15327  218 LGSFFPALKPSeMVFKVIF----WLGYFNSCVNPIIYPCSSKEFKR 259
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
44-324 1.31e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 55.71  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYA---AMDYHWVFGTAMckisnFL 118
Cdd:cd15069    4 VALELIIAALSVAGNVLVCaAVGTNSTLQTPTNYFLVSLAAADVAVGLFaIPFAITISlgfCTDFHSCLFLAC-----FV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMfTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTanlhgKISCFNnfslST 197
Cdd:cd15069   79 LVLTQ-SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNKA-----MSATNN----ST 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSWPTHS---------QMDPVGYsrhmVVTVTRFLCgFLVPVLIITACYLTI---VCK-LQRNRLAKTKKPF----- 259
Cdd:cd15069  149 NPADHGTNHScclisclfeNVVPMSY----MVYFNFFGC-VLPPLLIMLVIYIKIflvACRqLQRTELMDHSRTTlqrei 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 260 ---KIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15069  224 haaKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
41-325 1.46e-08

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 55.13  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIiaTFKMKKTVNMV---WFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISN 116
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLL--SFYVDRNIRQPsnyFIASLAVSDLLIGLEsMPFYTVYVLNGDYWPLGWVLCDLWL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLafflssPSLVFrdtanlhgKISCFNNFSLS 196
Cdd:cd15302   79 SVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWII------PALLF--------FISIFGWQYFT 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSWPTHSqmdpvgYSRHMVVTVtrFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPY 276
Cdd:cd15302  145 GQGRSLPEGEC------YVQFMTDPY--FNMGMYIGYYWTTLIVMLILYAGIYRAANRARKALRTITFILGAFVICWTPY 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 277 HTLNLLELHHTAmPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15302  217 HILATIYGFCEA-PPCVNETLYTISYYLCYMNSPINPFCYALANQQFKK 264
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
49-324 1.58e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.94  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15304    9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLmSLAIADMLLGFLvMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF--RDTANLHGKISCF---NNFslstpgss 201
Cdd:cd15304   89 IMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFglQDDSKVFKEGSCLladENF-------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 swpthsqmdpvgysrhmvVTVTRFLcGFLVPVLIITACYLTIVCKLQRNrLAKTKKPFKIIVTIIITFFLCWCPYHTLNL 281
Cdd:cd15304  161 ------------------VLIGSFV-AFFIPLTIMVITYFLTIKSLQQS-ISNEQKASKVLGIVFFLFVVMWCPFFITNV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 282 LEL--HHTAMPGSVFSLgLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15304  221 MAVicKESCNEVVIGGL-LNVFVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
41-325 2.29e-08

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 54.80  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVaVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMAcMVIWVLAFFLS-SPSLVFRDTANLHGKISCfnNFSLSTP 198
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVML-GGCWVIPTFISfLPIMQGWNHIGIEDLIAF--NCASGST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpthsqmdpvgYSRHMVVTVTRFLC---GFLVPVLIITACYLTIV-----------------------CKLQRNRL 252
Cdd:cd15056  158 ---------------SCVFMVNKPFAIICstvAFYIPALLMVLAYYRIYvaareqahqirslqragssnheaDQHRNSRM 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 253 AKTKKPFKIIVTIIITFFLCWCPYHTLNLLE-LHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15056  223 RTETKAAKTLGIIMGCFCVCWAPFFVTNIVDpFIGYRVPYLLWTAFL----WLGYINSGLNPFLYAFFNKSFRR 292
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
42-324 2.80e-08

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 54.30  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKK-TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15104    1 AAGVILAVLSPLIITGNLLVIVaLLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF--RDTANLHGKISCFNNFslst 197
Cdd:cd15104   81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISpqFQQTSYKGKCSFFAAF---- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 pgssswpthsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTIVC------------------KLQRNRLAKTKKPF 259
Cdd:cd15104  157 -------------------HPRVLLVLSCMVFFPALLLFVFCYCDILKiarvhsraiykvehalarQIHPRRTLSDFKAA 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 260 KIIVTIIITFFLCWCPYHTLNLLELH-HTAMPGSVFSLGLPLataLAIANSCMNPILYVFMGQDFK 324
Cdd:cd15104  218 RTVAVLIGCFLLSWLPFQITGLVQALcDECKLYDVLEDYLWL---LGLCNSLLNPWIYAFWQKEVR 280
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
52-324 2.95e-08

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 54.45  E-value: 2.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  52 FLGILGN--GLVIIIATFKMKKTVNMVWFL--NLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSV 127
Cdd:cd15077    9 FLVIAGFpiNVLTIICTIKYKKLRSHLNYIlvNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRlAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCfnnfslstpGSSSWPTH 206
Cdd:cd15077   89 WSLAVVAFERFLVICKPLGNFTFRGTH-AIIGCIATWVFGLAASLPPLFGWSRYIPEGlQCSC---------GPDWYTTN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 207 SQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKL-----QRNRLAKTKKP----FKIIVTIIITFFLCWCPYH 277
Cdd:cd15077  159 NKWNNESY------VMFLFCFCFGVPLSIIVFSYGRLLLTLravakQQEQSASTQKAerevTKMVVVMVLGFLVCWLPYA 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 278 TLNLLELHHTampGSVFSLGL-PLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15077  233 SFALWVVTNR---GEPFDLRLaSIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
49-325 4.43e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 53.76  E-value: 4.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15305    9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLmSLAVADMLVGILvMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV--FRDTANLHGKISCFNNfslstpgssswp 204
Cdd:cd15305   89 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVigLQDDEKVFVNGTCVLN------------ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 205 thsqmDPvgysrhMVVTVTRFLcGFLVPVLIITACYLTIVCKLQRNRLAKT-KKPFKIIVTIIITFFLCWCPYHTLNLLE 283
Cdd:cd15305  157 -----DE------NFVLIGSFV-AFFIPLIIMVITYCLTIQVLQRQQAINNeRRASKVLGIVFFLFLIMWCPFFITNILS 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 284 -LHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15305  225 vLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRR 267
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
43-325 5.15e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 53.59  E-value: 5.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFN-VFLPIHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15050    3 LGIALSTISLITVILNLLVLYaVRTERKLHTVGNLYIVSLSVADLIVGaVVMPLNIVYLLES-KWILGRPVCLFWLSMDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANlhgkiscfnnfslstpGS 200
Cdd:cd15050   82 VASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFAR----------------GG 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMDPVGYSRHMVVTVTRFLcGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHTLN 280
Cdd:cd15050  146 ERVVLEDKCETDFHDVTWFKVLTAIL-NFYIPSLLMLWFYAKIFKAVNRER-----KAAKQLGFIMAAFILCWIPYFILF 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 281 L-LELHHTAMPGSVFslglpLATA-LAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15050  220 MvIAFCKNCCNENLH-----MFTIwLGYINSTLNPFIYPLCNENFKK 261
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
64-321 6.36e-08

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 53.47  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  64 IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKIsnFLLIH--NMFTSVFLLTIISSDRCISV 141
Cdd:cd15169   26 TAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPV--FAVAHfaPLYAGGGFLAALSAGRYLGA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 142 LLPVWSQNHRSVRLAYMACMVIWvlAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGySRHMVVT 221
Cdd:cd15169  104 AFPLGYQAFRRPCYSWGVCAAIW--ALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPAS-AGPARFS 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 222 VTRFLcgFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVT--IIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLP 299
Cdd:cd15169  181 LSLLL--FFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAggALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLI 258
                        250       260
                 ....*....|....*....|..
gi 215272319 300 LATALAIanscMNPILYVFMGQ 321
Cdd:cd15169  259 TGAWSVV----LNPLVTGYLGR 276
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
44-318 7.77e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 53.24  E-value: 7.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMKKTVNM-VWFLNLAVADFLFNVF--LPiHITYAAMDyHWVFGTAMCKISNFLLI 120
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMhVFMLHLCIADLVVAFFqvLP-QLVWDITD-RFRGPDVLCRLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACmVIWVLAFFLSSPSL-VFRDTANLHGKISCFNNFSlstpg 199
Cdd:cd15388   82 VGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVC-VAWAISLILSLPQVfIFSKVEVAPGVYECWACFI----- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 sSSWpthsqmDPVGYSRHMVVTVtrflcgFLVPVLIITACYLTIVCKLQRNRLAKTK----------------------- 256
Cdd:cd15388  156 -EPW------GLKAYVTWITLVV------FVLPTLIITVCQVLIFKEIHINIYLKSQiivavvkkkqllssrassvaevs 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 257 ----KPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMP--GSVFSLGLPLATalaiANSCMNPILYVF 318
Cdd:cd15388  223 kamiKTVKMTLVIVLVYVLCWAPFFLVQLWSVWDPKAPteGATFTILMLLAS----LNSCTNPWIYMA 286
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
43-325 8.17e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 53.02  E-value: 8.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYhWVFGTAMCKIsnFLLI 120
Cdd:cd15323    3 LAAVVGFLIVFTIVGNVLVVIaVLTSRALRAPQNLFLVSLASADILVaTLVMPFSLANELMGY-WYFGQVWCNI--YLAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMF--TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDtanlhgkiscfnnfslSTP 198
Cdd:cd15323   80 DVLFctSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMY----------------RDP 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVcklqRNRLAKTKKPFKIIVTIIITFFLCWCPY-- 276
Cdd:cd15323  144 EGDVYPQCKLNDETWY------ILSSCIGSFFAPCLIMILVYIRIY----RVAKAREKRFTFVLAVVMGVFVVCWFPFff 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 215272319 277 -HTLNLLELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15323  214 sYSLYGICREACEVPEPLFKFFF----WIGYCNSSLNPVIYTIFNQDFRR 259
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-324 8.84e-08

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 52.94  E-value: 8.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  34 LEARVTRIFLVVVYSIVCFLGILGNGLVIIIATF--KMKKTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAM 111
Cdd:cd15084    4 LAPRSTYLTVAVLMGMVVALASFVNGLVIVVSIKykKLRSPLNYI-LVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 112 CKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVFRDTANLHG-KISCF 190
Cdd:cd15084   83 CEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGlRTSCG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 191 NNFSLSTPGSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTIVCKL-----QRNRLAKTKKPFKIIVTI 265
Cdd:cd15084  162 PNWYTGGTNNNSY-----------------ILALFVTCFALPLSTIIFSYSNLLLTLravaaQQKESETTQRAEKEVTRM 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 266 IITFFL----CWCPYHTLNLLELHHTAMPGSVFSLGLPlaTALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15084  225 VIAMVMafliCWLPYATFAMVVATNKDVVIQPTLASLP--SYFSKTATVYNPIIYVFMNKQFR 285
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
42-325 1.04e-07

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 52.34  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15309    2 YYAMLLTLLIFVIVFGNVLVCMaVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLP-VWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlhgkiscfnnFSLSTPG 199
Cdd:cd15309   82 MMCTASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLL-----------------FGLNNTD 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSswpthsqmdpVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQrnrlaKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15309  145 QN----------ECIIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLQ-----KEKKATQMLAIVLGVFIICWLPFFIT 209
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 280 NLLELHHTA-MPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15309  210 HILNMHCDCnIPPALYS----AFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
44-325 1.11e-07

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 52.61  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVcfLGILGNGLVIIiATFKMKKTVNM--VWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15401    6 VLIFTIV--VDVLGNLLVIL-SVLRNKKLRNAgnIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvFRDTANLHGKI-SCfnnfSLSTPGS 200
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNF-FVGSLQYDPRIySC----TFAQTVS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTI----------VCKLQRNRLAKTK-KPFKIIVTIIITF 269
Cdd:cd15401  158 SSY-----------------TITVVVVHFIVPLSIVTFCYLRIwvlviqvkhrVRQDSKQKLKANDiRNFLTMFVVFVLF 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 270 FLCWCPYHTLNL-LELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15401  221 AVCWGPLNFIGLaVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
60-324 1.52e-07

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 52.14  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  60 LVIIIATFKMKKTVNMVwFLNLAVADfLFNVFLPIHIT-YAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRC 138
Cdd:cd15080   22 LYVTVQHKKLRTPLNYI-LLNLAVAD-LFMVFGGFTTTmYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 139 ISVLLPV----WSQNHrsvrlAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnNFSLSTP---GSSSWPTHSQMDP 211
Cdd:cd15080  100 VVVCKPMsnfrFGENH-----AIMGVAFTWVMALACAAPPLV---------------GWSRYIPegmQCSCGIDYYTLKP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 212 VGYSRHMVVTVtrFLCGFLVPVLIITACYLTIVCKL-----QRNRLAKTKKPFK----IIVTIIITFFLCWCPYHTLNLL 282
Cdd:cd15080  160 EVNNESFVIYM--FVVHFTIPLIVIFFCYGRLVCTVkeaaaQQQESATTQKAEKevtrMVIIMVIAFLICWVPYASVAFY 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 283 ELHHTampGSVFS-LGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15080  238 IFTHQ---GSDFGpIFMTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
41-325 1.56e-07

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 52.50  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNF-- 117
Cdd:cd14996    1 VALPIIYSFLFVTGVFGNLLSLwVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFfg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 -LLIH-NMFTSVFLLTII------------SSDRCISVLLPVWS----QNHRSVRLAYMACMVIWVLAFFLSSPSLVF-- 177
Cdd:cd14996   81 tLVIHvSMCVSILILSWIaisryatlmkhdSATQKQSCYEKIFYghflKRFRQPKFARYLCIYIWGVVLCIIIPVVVYys 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 178 RDTANLHGKISCFNnfslstpgssswpthSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYL-TIVCKLQRNRLAKTK 256
Cdd:cd14996  161 VREADEDGESLCYN---------------RQVELGAKGSQIAGLIATTFFFLFFLVVLLSYYSFvNHLRRIQKNTCISEK 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 257 -----KPFKIIVTIIITFFLCWCPYHTLNLLELH-HTAMPGSVFSLGLP---LATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd14996  226 dliyrSVKRNILIIQALLVVCFLPYHIFKPVFYVlHQREDCQQLNYLIEtknILTCLASARSSTDPIMYLLLDKTFKK 303
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
28-325 2.35e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 51.72  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  28 LEDLSPLEARVTRIFLVVVYSIVcflgiLGNGLVIIIATFKMK---KTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYH 104
Cdd:cd15082    5 LKSIAPWNFTVLAALMFVVTSLS-----LAENFAVMLVTFRFKqlrQPLNYI-IVNLSVADFLVSLTGGTISFLTNARGY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 105 WVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVfrdtanlh 184
Cdd:cd15082   79 FFLGVWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQG-KHAALGLLFVWTFSFIWTIPPVL-------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 185 gkisCFNNFSLSTPGSSSwpthsqmDPVGYSRHM---VVTVTRFLCGFLVPVLIITACYLTIVCKLQ-----RNRLAKTK 256
Cdd:cd15082  150 ----GWSSYTVSKIGTTC-------EPNWYSGNMhdhTYIITFFTTCFILPLGVIFVSYGKLLQKLRkvsntQGRLGNAR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 257 KP----FKIIVTIIITFFLCWCPYHTLNLLElhhTAMPGSVFSLGLPLATALAIANSCM-NPILYVFMGQDFKK 325
Cdd:cd15082  219 KPerqvTRMVVVMIVAFMVCWTPYAAFSILV---TAHPTIHLDPRLAAIPAFFSKTAAVyNPIIYVFMNKQFRK 289
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
44-318 2.95e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 51.34  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNgLVIIIATFKM-KKTVNMVWF-LNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15386    4 IGVLAAILVVATAGN-LAVLLAMYRMrRKMSRMHLFvLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQnHRSVRLAYMACMVIWVLAFFLSSPSLV---FRDTANLHGKISCFNNFSLSTP 198
Cdd:cd15386   83 SMFASTYMLIMMTVDRYIAVCHPLRTL-QQPSRQAYLMIGATWLLSCILSLPQVFifsLREVDQGSGVLDCWADFGFPWG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSS--SWPThsqmdpvgysrhmvvtvtrfLCGFLVPVLIITACYLTIVCKLQRNRLAKTK-------------------- 256
Cdd:cd15386  162 AKAyiTWTT--------------------LSIFVLPVAILIVCYSLICYEICKNLKGKTQtsrsegggwrtqgmpsrvss 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 257 ---------KPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFS-LGLPLATALAIANSCMNPILYVF 318
Cdd:cd15386  222 vrtisrakiRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPDEDSSdFAFTITMLLASLSSCCNPWIYMF 293
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
42-325 3.88e-07

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 50.98  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVIII-ATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd15078    2 LLALLIATIGFLGVCNNLLVLILyYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRlaymACMVIWVLAFFLSSPSLV--FRDTANLHGkISCFNNFSLSTP 198
Cdd:cd15078   82 LFGIVSIMTLTVLAYERYIRVVHAKVVNFSWSWR----AITYIWLYSLAWTGAPLLgwNRYTLEVHG-LGCSFDWKSKDP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQRNR-------------LAKTKKPFKIIVTI 265
Cdd:cd15078  157 NDTSF-----------------VLLFFLGCLVVPLGIMAYCYGHILYEIRMLRsvedlqtfqvikiLKYEKKVAKMCLLM 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215272319 266 IITFFLCWCPYHTLNLLElhhTAMPGSVFSLGLPLATAL-AIANSCMNPILYVFMGQDFKK 325
Cdd:cd15078  220 ISTFLICWMPYAVVSLLV---TSGYSKLVTPTIAIIPSLfAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
46-316 9.34e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 49.91  E-value: 9.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15959    6 LLSLAILVIVGGNLLVIVaIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV---FRDTANLHGKiSCFNNfslstPGSS 201
Cdd:cd15959   86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMnqwWRDGADEEAQ-RCYDN-----PRCC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 202 SWPThsqmdpvgysrHMVVTVTRFLCGFLVPVLIITACYLTI------------------------------VCKLQRNR 251
Cdd:cd15959  160 DFVT-----------NMPYAIVSSTVSFYVPLLVMIFVYVRVfvvatrqvrlirkdkvrfppeesppaesrpACGRRPSR 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 252 L--AKTKKPFKIIVTIIITFFLCWCPYHTLNLLE-LHHTAMPGSVFsLGLplaTALAIANSCMNPILY 316
Cdd:cd15959  229 LlaIKEHKALKTLGIIMGTFTLCWLPFFVANIIKvFCRSLVPDPAF-LFL---NWLGYANSAFNPIIY 292
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
42-326 1.09e-06

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 49.45  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGIL-GNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15308    1 AAALVGGVLLILAIIaGNVLVCLsVCTERALKTTTNYFIVSLAVADLLLALLvLPLYVYSEFQGGVWTLSPVLCDALMTM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVwSQNHRSVRLAYMACM-VIWVLAFFLSSPSLvfrdtanlhgkiscfnnFSLST 197
Cdd:cd15308   81 DVMLCTASIFNLCAISVDRFIAVSVPL-NYNRRQGSVRQLLLIsATWILSFAVASPVI-----------------FGLNN 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSSwPTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYH 277
Cdd:cd15308  143 VPNRD-PAVCKLEDNNY------VVYSSVCSFFIPCPVMLVLYCAMFRGLGRER-----KAMRVLPVVVGAFLFCWTPFF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215272319 278 TLNLLE--LHHTAMPGSVFSLglplATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15308  211 VVHITRalCESCSIPPQLISI----VTWLGYVNSALNPVIYTVFNAEFRNV 257
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
45-325 1.12e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 49.47  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLG----ILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15318    1 LVIYLACAIGmliiVLGNLFVVVtVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSL----VFRDTANLHGKISCFNNFSL 195
Cdd:cd15318   81 TLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLytkaVEEGLAELLTSVPCVGSCQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWPTHsqmdPVgysrhmvvtvtrflcgFLVPVLIITACYLTIVCKLQR------------NRLAKT-KKPFKII 262
Cdd:cd15318  161 LYNKLWGWLNF----PV----------------FFIPCLIMIGLYVKIFIVAKRqaraiasllsdtNGASKReRKAAKTL 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 263 VTIIITFFLCWCPYHTLNLLE-LHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15318  221 GIAVGVYLLCWLPFTIDTMVDsLLNFITPPLLFDIII----WFAYFNSACNPLIYVFSYPWFRK 280
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
44-172 1.14e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.55  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIII---ATFKMKKTVNMVWFLNLAVADFLFNVFL-PIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd14981    4 PAPPALMFVFGVLGNLLALIVlarSSKSHKWSVFYRLVAGLAITDLLGILLTsPVVLAVYASNFEWDGGQPLCDYFGFMM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSS 172
Cdd:cd14981   84 SFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS 136
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
41-176 1.15e-06

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 49.85  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFK--MKKTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15403    1 ILLAIVMILMIAIGFLGNAIVCLIVYQKpaMRSAINLL-LATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAML 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 119 LIHNMFTSVFLLTIISSDRcisVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV 176
Cdd:cd15403   80 YWFFVLEGVAILLIISVDR---FLIIVQRQDKLNPHRAKVMIAISWVLSFCISFPSVV 134
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
47-176 1.36e-06

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 49.37  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  47 YSIVCFLGILGN--GLVIIIATFKMKKTVNmVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15167    7 YYLIFLIGFIGScfALWAFIQKRSSRKCIN-IYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMY 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV 176
Cdd:cd15167   86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMA 137
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
38-325 1.68e-06

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 49.10  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  38 VTRIFLVVVYSIVCFlgilGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLPIhITYAAMDYH---------WVF 107
Cdd:cd15965    2 VQRVFVWVVSAVTCF----GNIFVICMRPYiRSENKLHAMSIISLCCADCLMGIYLFV-IGAFDLKYRgeynkhaqlWMD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 108 GTAmCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRlAYMACMVIWVLAFFLSSPSLVFRDTanlhgki 187
Cdd:cd15965   77 STQ-CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCR-TITILILIWIIGFIIAFIPLSNKEF------- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 188 scFNNFsLSTPGSSsWPTHS-QMDPVGYSRHMVVTvtrFLCGFLVPVLIITACYLTIVCKLQR---------NRLAKTKK 257
Cdd:cd15965  148 --FRNY-YGTNGVC-FPLHSeQPESTGAQIYSVVI---FLGLNLAAFIIIVFSYGSMFYSIHQtaimateisNHIKKEMT 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 258 PFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALaiaNSCMNPILYVFMGQDFKK 325
Cdd:cd15965  221 LAKRFFFIVFTDALCWIPIFILKLLSLLQVEIPGTISSWVVIFILPI---NSALNPILYTLTTRPFKE 285
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
42-325 1.75e-06

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 49.13  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLpihITYAAMDYH-----------WVFGT 109
Cdd:cd15964    2 FLRIVVWFVNLLAILGNVFVLlILLTSHYKLTVPRFLMCNLAFADFCMGIYL---LLIASVDLHtrseyynhaidWQTGP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 110 AmCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVwsQNHRSVRLAYMACMVI--WVLAFFLSSPSLVfrdtanlhgKI 187
Cdd:cd15964   79 G-CNTAGFFTVFASELSVYTLTVITLERWYAITFAM--RLDRKIRLRHASAIMLggWVFCFLLALLPLV---------GV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 188 SCFNNFSLSTPGSSSWPThsqmdpvgySRHMVVTVtrfLCGFLVPVLIITACYLTIVCKL---QRNRLAKTKKPFKIIVT 264
Cdd:cd15964  147 SSYAKVSICLPMDTETPL---------AQAYIVFV---LMLNIIAFVIICACYIKIYITVrnpQYKSGDKDTKIAKRMAV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 265 IIITFFLCWCP--YHTLNLLeLHHTAMPGSVFSLGLPLATALaiaNSCMNPILYVFMGQDFKK 325
Cdd:cd15964  215 LIFTDFICMAPisFYALSAI-LNKPLITVSNSKILLVLFYPL---NSCANPFLYAIFTKAFRR 273
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
43-330 2.07e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.58  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVC-FLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFlpihiTY---AAMDYH--WVFGTAMCKIS 115
Cdd:cd15073    2 IVAAYLIVAgIISTISNGIVLvTFVKFRELRTPTNALIINLAVTDLGVSII-----GYpfsAASDLHgsWKFGYAGCQWY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 116 NFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMAcMVIWVLAFFLSSPSLVfrdtanlhgKISCFNNFSL 195
Cdd:cd15073   77 AFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMI-LLAWTNAFFWAAMPLV---------GWASYALDPT 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGSSSWpTHSQMDPVGYsrhmvvTVTRFLCGFLVPVLIITACYLTIVCKLQR----------NRLAKTKKPF-KIIVT 264
Cdd:cd15073  147 GATCTINW-RKNDSSFVSY------TMSVIVVNFIVPLAVMFYCYYNVSRFVKKvlasdclesvNIDWTDQNDVtKMSVI 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 265 IIITFFLCWCPYHTLNLLELHhtAMPGSVFSLGLPLATALAIANSCMNPILYVFMGqdfKKFKVAL 330
Cdd:cd15073  220 MIVMFLVAWSPYSIVCLWASF--GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIAN---KKFRRAI 280
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
43-325 2.33e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 48.40  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYhWVFGTAMCKISNFLLI 120
Cdd:cd15322    3 LIILVGLLMLLTVFGNVLVIIaVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGY-WYFGKVWCEIYLALDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfnnfslSTPGS 200
Cdd:cd15322   82 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-------------------TIEKK 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPthsQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVcKLQRNRlakTKKPFKIIVTIIITFFLCWCP-YHTL 279
Cdd:cd15322  143 SGQP---EGPICKINDEKWYIISSCIGSFFAPCLIMVLVYIRIY-QIAKNR---EKRFTFVLAVVIGVFVICWFPfFFTY 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 215272319 280 NLLELHHTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15322  216 TLTAVCDCSVPETLFKFFF----WFGYCNSSLNPVIYTIFNHDFRR 257
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
42-316 2.78e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.60  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  42 FLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLL 119
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIaIARTSRLQTMTNIFITSLACADLVMGLLvVPLGATIVVTG-KWQLGNFWCELWTSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTANLHGKISCFNN------ 192
Cdd:cd15058   81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDCYQDptccdf 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 193 -----FSLSTPGSSSWPTHSQMDPVgYSRHMVVTVT----------RFLCGFLVPVLIITACYLTivCKLQRNRL--AKT 255
Cdd:cd15058  161 rtnmaYAIASSVVSFYIPLLIMIFV-YARVFLIATRqlqlidkrrlRFQSECPAPQTTSPEGKRS--SGRRPSRLtvVKE 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 256 KKPFKIIVTIIITFFLCWCPYHTLNLLE-LHHTAMPGSVFSlglpLATALAIANSCMNPILY 316
Cdd:cd15058  238 HKALKTLGIIMGTFTLCWLPFFIANIINvFNRNLPPGEVFL----LLNWLGYINSGLNPIIY 295
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-324 4.37e-06

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 47.87  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGL-VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15132    1 IPVTIVCLILFVVGVTGNTMtVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGkiscfnnfslSTPG 199
Cdd:cd15132   81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNN----------IHPD 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsQMDPVGYSRH-------MVVTVTRFLCgflvPVLIITACYLTIVCKLQR-----------NRLAKTKKPFKI 261
Cdd:cd15132  151 DFSR----ECKHTPYAVSsgllgimIWVTTTYFFL----PMLCLSFLYGFIGRKLWKskndlrgpnaaARERSHRQTVRI 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 262 IVTIIITFFLCWCPYHTLNLL----ELHHTAMPGSVFSLglpLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15132  223 LAVVVLAFIICWLPFHIGRILfantEDYRTMMFSQYFNI---VAMQLFYLSASINPILYNLISRKYR 286
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
46-325 4.87e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 47.73  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLpihITYAA---MDYHWVFGTAMCKIsnFLLIH 121
Cdd:cd15065    5 FLSLIIVLAIFGNVLVCLaIFTDRRLRKKSNLFIVSLAVADLLVALLV---MTFAVvndLLGYWLFGETFCNI--WISFD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFT--SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-----------SPSLVFRDTANLHGKIS 188
Cdd:cd15065   80 VMCStaSILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISflpihlgwhrlSQDEIKGLNHASNPKPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 189 CFnnFSLSTPGSsswpthsqmdpVGYSrhmvvtvtrfLCGFLVPVLIITACYLTIVC---KLQRN-----RLAKTKKPFK 260
Cdd:cd15065  160 CA--LDLNPTYA-----------VVSS----------LISFYIPCLVMLLIYSRLYLyarKHVVNiksqkLPSESGSKFQ 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 261 IIVTIIITFF--------------------LCWCPYHTLNLLE-LHHTAMPGSVFSLglplATALAIANSCMNPILYVFM 319
Cdd:cd15065  217 VPSLSSKHNNqgvsdhkaavtlgiimgvflICWLPFFIINIIAaFCKTCIPPKCFKI----LTWLGYFNSCLNPIIYSIF 292

                 ....*.
gi 215272319 320 GQDFKK 325
Cdd:cd15065  293 NSEFRR 298
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
45-325 6.78e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 47.14  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNV----FLPIHITYAamdyHWVFGTAMCKISNFLL 119
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVcLVIHRSRRTQSTTNYFVVSMACADLLLSVasapFVLLQFTSG----RWTLGSAMCKLVRYFQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVrlAYMACMVIWVLAFFLSSPSLVFRDTAnlhgKISCFNNFSlstpg 199
Cdd:cd15008   80 YLTPGVQIYVLLSICVDRFYTIVYPLSFKVSREK--AKKMIAASWLFDAAFVSPALFFYGSN----WGPHCNFFL----- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWpthsqmDPVGYSrhmvvtVTRFLCGFLVPVLIITACYLTIVCKLQR------------NRLAKTK-KPFKIIVTII 266
Cdd:cd15008  149 PDSW------DGAAYA------IIHLLVGFLVPSILIILFYQKVIKYIWRigtdgrtvrrtmNIVPRTKvKTIKMFLMLN 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 267 ITFFLCWCPYHTLNLLELHHTAMPGSvfSLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15008  217 SMFLLSWLPFYVVQLWHPRESDYRQS--SLVFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
44-324 7.77e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 47.08  E-value: 7.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVF-LPIHITYA-AMDYHWVFGTAMCkisnFLLI 120
Cdd:cd15070    4 ISIEILIGLCAVVGNVLVIWVVKLNPSlRTTTFYFIVSLALADIAVGVLvIPLAIVVSlGVTIHFYSCLFMS----CLLV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFflsspslvfrdtanLHGKISCFN-NFSLSTPG 199
Cdd:cd15070   80 VFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSF--------------LVGLTPMFGwNRKPSLES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 200 SSSWPTHSQMDPVGYSRHMVVTvtRFLCGFLVPVLIITACYLTIVcKLQRNRLA--------------KTKKPFKIIVTI 265
Cdd:cd15070  146 VNTTPLQCQFTSVMRMDYMVYF--SFFTWILIPLVIMCALYVDIF-YIIRNKLSqnatgfretgafygREFKTAKSLALV 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 215272319 266 IITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATAlaiaNSCMNPILYVFMGQDFK 324
Cdd:cd15070  223 LFLFAVCWLPLSIINCVVYFNPKVPKIALYLGILLSHA----NSMMNPIVYACKIKKFK 277
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
41-319 1.39e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 46.08  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKISNFL 118
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIIsIAHFKQLHTPTNYLILSLAVADLLVGGLvMPPSMVRS-VETCWYFGDLFCKIHSSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSpSLVFrdtANLHGKISCFNNfslstp 198
Cdd:cd15314   80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGF-GIIF---LELNIKGIYYNH------ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 gssswpTHSQMDPVGYSRHMVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNRLA--------------KTKKPFKIIVT 264
Cdd:cd15314  150 ------VACEGGCLVFFSKVSSVVGSVFS-FYIPAVIMLCIYLKIFLVAQRQARSiqsartksgassskMERKATKTLAI 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 265 IIITFFLCWCPYHTLNLLE--LHHTAmPGSVFSLglplATALAIANSCMNPILYVFM 319
Cdd:cd15314  223 VMGVFLLCWTPFFLCNIIDpfINYSI-PPVLIEV----LNWLGYSNSTLNPFIYAFF 274
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
44-318 1.53e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 46.13  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVI--IIATFKMKKTvnMVWFL-NLAVADFLFNVFLpihiTYAAMDYHWVFGTAMCKISNFL-- 118
Cdd:cd14972    2 LVVAIVLGVFIVVENSLVLaaIIKNRRLHKP--MYILIaNLAAADLLAGIAF----VFTFLSVLLVSLTPSPATWLLRkg 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 -LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTANLHGkiSCfnnfsls 196
Cdd:cd14972   76 sLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQE--SC------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 tpgssswpthSQMDPvGYSRHMVVTVTRFlcgFLVPVLIITACYLTIVCKLQRN--------------RLAKTKKPFKII 262
Cdd:cd14972  147 ----------SPLGP-GLPKSYLVLILVF---FFIALVIIVFLYVRIFWCLWRHanaiaarqeaavpaQPSTSRKLAKTV 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 263 VTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLplATALAIANSCMNPILYVF 318
Cdd:cd14972  213 VIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFYY--FLVLALLNSAINPIIYAF 266
7tmA_MAS1L cd15113
mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of ...
49-177 1.65e-05

mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of seven-transmembrane G protein-coupled receptors; MAS1L is also called MAS1 oncogene-like (MAS1-like) or mas-related G-protein coupled receptor MRG. MAS1L is a G protein-coupled receptor that only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L. The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320241  Cd Length: 265  Bit Score: 45.98  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLF-NVFLPIHITYAAMDYHWVfgtaMCKISNFLLIHNMFT-- 125
Cdd:cd15113    9 LVSLCGLVGNGVVFWLLCCGVRSNPYMVYILNLAAADVINlSCSAVILLEVTLLLYHGV----TLFVADFLEPVSYFSdt 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 215272319 126 -SVFLLTIISSDRCISVLLPVWsQNHRSVRLAYMACMVIWVLAFFLSSPSLVF 177
Cdd:cd15113   85 vGLCLLVAISTESCLCVLFPIW-CCHRPKYTSAVVSTLSWGLPLSLHIVKSLC 136
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
49-171 2.24e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.91  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFlGILGNGLV-IIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15005   10 ILCV-SLAGNLLFsVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHS 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 127 VFLLTIISSDRCISVllpvwsQNHR--SVRLAYMACMVIWVLAFFLS 171
Cdd:cd15005   89 AFTLFCIAVTRYMAI------AHHRfyAKRMTFWTCLAVICMAWTLS 129
7tmA_MrgprG cd15111
mas-related G protein-coupled receptor subtype G, member of the class A family of ...
49-166 2.24e-05

mas-related G protein-coupled receptor subtype G, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320239  Cd Length: 263  Bit Score: 45.55  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLfnvFLPIHITYAAMdyHWVFGTAmcKISNFLLIHNMFTS-V 127
Cdd:cd15111    9 IVSLAGLVGNGLVLWHLGFHIKKGPFSNYLLHLAAADFL---FLSCQVGFSIA--QAALGSE--DTLYFVVTFLWFAAgL 81
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVL 166
Cdd:cd15111   82 WLLAAFSVERCLSYLFPACCQGCRPRWTSAVLCAVVWVL 120
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-324 3.10e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 45.23  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  53 LGILGNGLVIIIaTFKMKKTVN--MVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLL 130
Cdd:cd15085   13 FSIFNNVLVIAV-TLKNPQLRNpiNIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 131 TIISSDRCISVLLPVWSQNhRSVRLAYMACMVIWVLAFFLSspslvfrdTANLHGkISCFNNFSLSTPGSSSWPTHSQmd 210
Cdd:cd15085   92 TLLAYERYNVVCKPMGGLK-LSTKRGYQGLLFIWLFCLFWA--------VAPLFG-WSSYGPEGVQTSCSIGWEERSW-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 211 pvgysRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQ-----------RNRLAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15085  160 -----SNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHklnkkieqqggKNCPEEEERAVIMVLAMVIAFLICWLPYTVF 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 280 NLLELHHTAMpgSVFSLGLPLATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15085  235 ALIVVVNPEL--SISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
43-319 4.15e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 44.73  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVIIIaTFKMKKTVNMVWFL--NLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI 120
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLS-LVRLRKRPRSTRLLlaSLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 121 HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTanlhgkiscFNNFSLSTPGS 200
Cdd:cd14964   80 GANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGA---------IPRYNTLTGSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSQMdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTIV----------CKLQRNRLAKTKKPFKIIVTIIITFF 270
Cdd:cd14964  151 YLICTTIYL-----------TWGFLLVSFLLPLVAFLVIFSRIVlrlrrrvraiRSAASLNTDKNLKATKSLLILVITFL 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 271 LCWCPYHTLNLLELHHTAMPGSvfSLGLPLATALAIANSCMNPILYVFM 319
Cdd:cd14964  220 LCWLPFSIVFILHALVAAGQGL--NLLSILANLLAVLASTLNPFIYCLG 266
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
44-325 4.43e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.93  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVIIIATFKMK-KTVNMVWFLNLAVADFLFNVFlpihityaAMDYHWVFGTAMCK-------IS 115
Cdd:cd15068    4 ITVELAIAVLAILGNVLVCWAVWLNSNlQNVTNYFVVSLAAADIAVGVL--------AIPFAITISTGFCAachgclfIA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 116 NFLLIHNMfTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS-SPSLVFRDTANLHGKiscfNNFS 194
Cdd:cd15068   76 CFVLVLTQ-SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGlTPMLGWNNCGQPKEG----KNHS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 195 LSTPGSSSWPTHSQMDPVGYsrhmVVTVTRFLCgFLVPVLIITACYLTI---------------VCKLQ-RNRLAKTKKP 258
Cdd:cd15068  151 QGCGEGQVACLFEDVVPMNY----MVYFNFFAC-VLVPLLLMLGVYLRIflaarrqlkqmesqpLPGERaRSTLQKEVHA 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215272319 259 FKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLgLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15068  226 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWL-MYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
41-324 5.56e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 44.27  E-value: 5.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAaMDYHWVFGTAMCKISNFL 118
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAaILLERSLQGVSNYLILSLAVADLMVAVLvMPLSAVYE-VSQHWFLGPEVCDMWISM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNhRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlhgkiscfnnFSLSTP 198
Cdd:cd15331   80 DVLCCTASILHLVAIALDRYWAVTNIDYIRR-RTAKRILIMIAVVWFVSLIISIAPL-----------------FGWKDE 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVgySRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRlaktkKPFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15331  142 DDLDRVLKTGVCLI--SQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQAAKRER-----KAARTLAIITGAFVVCWLPFFL 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215272319 279 LNLLELHHTA--MPGSVFSLGLPLAtalaIANSCMNPILYVFMGQDFK 324
Cdd:cd15331  215 VALVMPFCGAwqISRFLESFFLWLG----YFNSLLNPIIYTIFSPDFR 258
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
41-171 5.58e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 44.46  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLL 119
Cdd:cd15316    1 VILYIVLGFGAVLAVFGNLLVMIsILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 215272319 120 IHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS 171
Cdd:cd15316   81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYS 132
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
48-325 7.60e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 44.18  E-value: 7.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  48 SIVCFLGILGNGLVI--IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGtAMCKISNFLLIHNMFT 125
Cdd:cd15319    8 SLLILWTLLGNILVCaaVVRFRHLRSKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 126 SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF---RDTANLHGKISCFNNFSLSTPGSSS 202
Cdd:cd15319   87 SILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLnwhKDSGDDWVGLHNSSISRQVEENCDS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 203 wpthsqmdpvgySRHMVVTVTRFLCGFLVPVLIITACYLTI--VCKLQRNRLA--------------------------- 253
Cdd:cd15319  167 ------------SLNRTYAISSSLISFYIPVAIMIVTYTRIyrIAQIQIRRISsleraaehaqscrsnridchhhtslrt 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 254 ---KTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSlGLPLATALAI--------ANSCMNPILYVFmGQD 322
Cdd:cd15319  235 sikKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPADPDA-GLPCVSETTFdvfvwfgwANSSLNPIIYAF-NAD 312

                 ...
gi 215272319 323 FKK 325
Cdd:cd15319  313 FRK 315
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
41-282 1.04e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 43.29  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFK--MKKTVNMVwFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFL 118
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKaaMRSAINIL-LASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRcisVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkiscfNNFSLSTP 198
Cdd:cd15404   80 FWLFVMEGVAILLIISIDR---FLIIVQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAV--------------GSPDLQIP 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 199 GSSSWPTHSQMDPVGYSRHMVVTVTRFlcgFLVPVLIITACYLTIvckLQRNRLAKTKKpFKIIVTIIITFFLCWCPYHT 278
Cdd:cd15404  143 SRAPQCVFGYTTNPGYQAYVILIMLIF---FFIPFMVMLYSFMGI---LNTVRSFKTRA-FTTILILFIVFTVCWAPFTT 215

                 ....
gi 215272319 279 LNLL 282
Cdd:cd15404  216 YSLV 219
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
44-318 1.11e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 43.60  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  44 VVVYSIVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15212    4 ALVLLAIFLLSSLGNCAVIgVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSRPGWLFGDRLCLANGFFNAC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDR-CISVLLPvwsQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGS 200
Cdd:cd15212   84 FGIVSTLTMTLISFDRyYAIVRQP---QGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SswpthsqmdPVGYSRHMVVTVtrfLCgFLVPVLIITACYLTIvCKLQRN---------------RLAKTKKPFKIIVTI 265
Cdd:cd15212  161 S---------RLGAAYSSVLIV---LC-YLLPFALMCFCHYNI-CKTVRLsesrvrpvttyahllRFYSEMRTATTVLIM 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215272319 266 IITFFLCWCPYHTLNLLelhhTAMPGSVFSLGL-PLATALAIANSCMNPILYVF 318
Cdd:cd15212  227 IVFIICCWGPYCLLGLV----AAAGGYQFPPLMdTVAIWMAWANGAINPLIYAI 276
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
43-177 1.14e-04

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 43.23  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCF-LGILGNGLvIIIATFKMKKTVNM--VWFLNLAVADFLFNVFLPIHI-----TYAAMdyhWVFGTAMCKI 114
Cdd:cd14990    2 LSLLYLIICFpVGLCYNAL-LVLVNLYNKASMTMpdVYFVNMAIAGLVLNAVAPVQLlgpdnTRWPL---WNSNNEVYIT 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215272319 115 SNFLLIHNMFTSVFLLTIISSDRCISVLLPvwSQNHRSVRLAYMACMVIWVLAFFLSSPSLVF 177
Cdd:cd14990   78 LLILFNVSSLVSMYSTTLLSLDYYIERALP--RTYMSSVYNTKHVCGFIWGGAVLTSFSSLLF 138
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
41-326 1.29e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 43.32  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFK-----MKKTVNMvWFLNLAVADFLFNVF-LPIHI-TYAAMDYHWVFGTAMCK 113
Cdd:cd15356    1 VLFTAVYALIWALGAAGNALTIHLVLKKrslrgLQGTVHY-HLVSLALSDLLILLIsVPIELyNFVWFHYPWVFGDLVCR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 114 ISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPslvfrdTANLHGKiscfnNF 193
Cdd:cd15356   80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALP------MAFIMGQ-----KY 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 194 SLSTPGSSSWPThSQMDPVGYSR---HMVVTVTRFLcGFLVPVLIITACYLTIVCKLQRNRLaktKKPFKIIVTIIITFF 270
Cdd:cd15356  149 ELETADGEPEPS-SRVCTVLVSRatlKVFIQVNAFV-SFVLPLALIAFLNGVTVSHLRIQSL---QHSVQVLRAIVIAYV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215272319 271 LCWCPYHTLNLLELHhtaMPGSVFSLGL--------PLATALAIANSCMNPILYVFMGQDFKKF 326
Cdd:cd15356  224 ICWLPYHARRLMFCY---VPDDAWTDSLynfyhyfyMLTNTLFYVSSAVNPLLYNVVSSSFRKL 284
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
40-178 1.45e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 43.24  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  40 RIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAmDYHWVFGTAMCK-ISNFL 118
Cdd:cd14994    1 TYSLIFLYSVVLIGGVIGVILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYA-SKTWKFGMPLCKmVSAMI 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 119 LIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRlAYMACMVIWVLAFFLSSPSLVFR 178
Cdd:cd14994   80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLH-AVAASAVVWVLVLLIVVPVFVKE 138
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
41-324 1.87e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 42.84  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIaTFKMKKTVNMVWF--LNLAVADFLFNVF--LPIHITYAAMdyHWVFGTAMCKISN 116
Cdd:cd15075    1 TILSIIMAVFSIASVVLNATVIIV-TLRHKQLRQPLNYalVNLAVADLGTTVFggLLSVVTNAVG--YFNLGRVGCVLEG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 117 FLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSvRLAYMACMVIWVLAFFLSSPSLVfrdtanlhgkisCFNNFSLS 196
Cdd:cd15075   78 FAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQT-RHALAGIASSWLWSLIWNTPPLF------------GWGSYQLE 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSSWPTHSQMDPVGYSrhmvVTVTRFLCGFLVPVLIITACY------LTIVCKLQRNRLAKTKKP----FKIIVTII 266
Cdd:cd15075  145 GVMTSCAPDWYSRDPVNVS----YILCYFSFCFAIPFAIILVSYgyllwtLRQVAKLGVAEGGSTAKAevqvARMVVVMV 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 267 ITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLatALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15075  221 MAFLLCWLPYAAFALTVVSKPDVYINPLIATVPM--YLAKSSTVYNPIIYIFMNKQFR 276
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
49-333 2.05e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 42.63  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHITYAAMDyHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15307    9 VLVLGTAAGNILVCLaIAWERRLQNVTNYFLMSLAITDLMVAVLvMPLGILTLVKG-HFPLSSEHCLTWICLDVLFCTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSP-SLVFRDtanlhgkiscfNNFSLSTPGSSSWPt 205
Cdd:cd15307   88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPlSLMYSK-----------DHASVLVNGTCQIP- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 206 hsqmDPVgysrhmVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNR------LAKTKKPFKIIVTIIITFFLCWCPYHTL 279
Cdd:cd15307  156 ----DPV------YKLVGSIVC-FYIPLGVMLLTYCLTVRLLARQRsrhgriIRLEQKATKVLGVVFFTFVILWSPFFVL 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 280 NLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKK-FKVALFSR 333
Cdd:cd15307  225 NLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQaFKKVLLCR 279
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
41-325 2.45e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 42.53  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGlvIIIATFKMKKTVNMV------WFLNLAVADFL-FNVFLPIHI-TYAAMDYHWVFGTAMC 112
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNS--ITLYTLARKKSLQHLqstvhyHLASLALSDLLiLLLAMPVELyNFIWVHHPWAFGDAAC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 113 KISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANL----HGKIS 188
Cdd:cd15355   79 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRsgthPGGLI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 189 CFNNFSLSTPGSsswpthsqmdpvgysrhmVVTVTRFLcGFLVPVLIITACYLTIVCKLQR------------------- 249
Cdd:cd15355  159 CTPIVDTSTLKV------------------VIQVNAFL-SFLFPMLVISVLNTLIANQLTVmvnqaeqenqvctiggqrt 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 250 --------NRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLL-----ELHHTAMPGSVFSLGLPLATALAIANSCMNPILY 316
Cdd:cd15355  220 vlsvsmepGRVQSLRHGVLVLRAVVIAFVVCWLPYHVRRLMfcyvsDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILY 299

                 ....*....
gi 215272319 317 VFMGQDFKK 325
Cdd:cd15355  300 NLVSANFRQ 308
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
41-325 2.75e-04

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 42.48  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCFLGILGNGLVIIIATFKMKK-------TVNMVwflNLAVADFLFNVF-LPIHITYAAMD-YHWVFGTAM 111
Cdd:cd15135    1 ITLTLLYSLILVAGILGNSATIKVTQVLQKKgylqksvTDHMV---SLACSDLLVLLLgMPVELYSAIWDpFATPSGNIA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 112 CKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMViWVLAFFLSSPSLV-----------FRDT 180
Cdd:cd15135   78 CKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFV-WLTSALVALPLLFamgtedpleafPSYR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 181 ANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVV-TVTRFLCGFLVPVLIITACYLTIVCK-------LQRNRL 252
Cdd:cd15135  157 GTRHHCQDQKSNLTICTSLSSKWTVFQASIFSAFVLYLLVlASVAFMCRRMMRALMGSKKGAVAVKGpggsvqlLRKHES 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 253 AKTKKPFKIIVTI----IITFFLCWCPYHTLNLLElhhTAMPGSVFSLG--------LPLATALAIANSCMNPILYVFMG 320
Cdd:cd15135  237 AEGKTARKQTILFlgliVGTLAVCWMPNQIRRIMA---AAKPKDDWTRSyfrayiilLPIADTFFYLSSVLNPLLYNLSS 313

                 ....*
gi 215272319 321 QDFKK 325
Cdd:cd15135  314 QQFRS 318
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
41-325 2.86e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 42.14  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  41 IFLVVVYSIVCfLGILGNglVIIIATFKMKKTVNMV---WFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNF 117
Cdd:cd15215    1 IRSVLIVIFLC-ASLFGN--IVLLLVFQRKPQLLQVanrFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKiscfNNFSLST 197
Cdd:cd15215   78 LMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDER----NALCSVI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 198 PGSSswpthsqmdpvgYSRHMVVTVTrflcGFLVPVLIITACYLTIVCKLQRNRLAKTKkpfKIIVTIIITFFLCWCPYH 277
Cdd:cd15215  154 WGSS------------YSYTILSVVS----SFVLPVIIMLACYSMVFRAARRCYHCKAA---KVIFIIIFSYVLSMGPYS 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 278 TLNLLELH-HTAMPGSVFSLGLplatALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15215  215 FLSVLAVWvDTQVPQWVISIIL----WLFFLQCCIHPYIYGYMHKSIKK 259
7tmA_MrgprE cd15112
mas-related G protein-coupled receptor subtype E, member of the class A family of ...
54-170 3.11e-04

mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320240  Cd Length: 272  Bit Score: 42.13  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  54 GILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFnvfLPIHITYAAMDY--------HWVFgTAMCKISNFLLIhnmfT 125
Cdd:cd15112   14 GLLGNGLVLWLLSSNVYRNPFSIYLLDVACADLIF---LCCHMVAIIPELlqnhlsfpHFVY-DSLLALRFFCYI----V 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 215272319 126 SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFL 170
Cdd:cd15112   86 GLSLLAAISAEQCLATLFPAWYQCRRPRHLTTCVCALLWALCLLL 130
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 4.07e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 41.76  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNG-LVIIIATFKMKKTVNMVWFLNLAVADFLFNVF-LPIHiTYAAMDYHWVFGTAMCKISNFLLIHN 122
Cdd:cd15976    5 VVSCLVFVLGIIGNStLLRIIYKNKCMRNGPNILIASLALGDLLHIIIdIPIN-VYKLLAEDWPFGVEMCKLVPFIQKAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 123 MFTSVFLLTIISSDRCISVllPVWSQNHRSVRLAYMAC--MVIWVLAFFLSSPSLVfrdtanlhgkisCFNNFSLSTPGS 200
Cdd:cd15976   84 VGITVLSLCALSIDRYRAV--ASWSRIKGIGVPKWTAVeiVLIWVVSIILAVPEAI------------GFDMITMDYKGE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPThsQMDPVGYSRHMVVTVTR-----FLCGFLVPVLIITACYLTIVCKLQRNR----------LAKTKKPFKIIVTI 265
Cdd:cd15976  150 LLRIC--LLHPIQKTAFMQFYKTAkdwwlFSFYFCLPLACTAVFYTLMTCEMLRKKngmqialndhLKQRREVAKTVFCL 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215272319 266 IITFFLCWCPYHTLNLLEL----HHTAMPGSVFSLGLPL---ATALAIANSCMNPILYVFMGQDFK 324
Cdd:cd15976  228 VLVFALCWLPLHLSRILKLtiydEKDPNRCELLSFFLVLdyiGINMASLNSCINPIALYLVSKRFK 293
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
53-316 8.45e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 40.51  E-value: 8.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  53 LGILGNG--LVIIIATFKMKKtvnMVWFLNLAVADFLFNVFL-PIHITYA-AMDYHWVFGTAMCKISNFLLIHNMFTSVF 128
Cdd:cd15220   12 TALVGNTavMVVIAKTPHLRK---FAFVCHLCVVDLLAALLLmPLGILSSsPFFLGVVFGEAECRVYIFLSVCLVSASIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 129 LLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVfrdtanlhGKISCFNNFSLSTPGSSSWPTHSQ 208
Cdd:cd15220   89 TISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVL--------GWPSYGGPAPIAARHCSLHWSHSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 209 mdpvgySRHMVVTVTRFLCgFLVPVLIITACYLTIVCKLQRNRLAKTkkpfkiIVTIIITFFLCWCPYHTLNLlelhHTA 288
Cdd:cd15220  161 ------HRGVFVVLFALVC-FLLPLLLILVVYCGVFKVFGGGKAALT------LAAIVGQFLCCWLPYFAFHL----YSA 223
                        250       260       270
                 ....*....|....*....|....*....|
gi 215272319 289 MPGSVFSLGLPLATALAIANSCM--NPILY 316
Cdd:cd15220  224 LAASPVSGGEAEEVVTWLAYSCFavNPFFY 253
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
40-325 1.23e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 40.37  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  40 RIFLVVVYSIVCFLGILGNGLVI--IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTaMCKISNF 117
Cdd:cd15320    1 RVLTGCFLSVLILSTLLGNTLVCaaVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 118 LLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFrdtaNLH-GKISCFNNFSLS 196
Cdd:cd15320   80 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQL----NWHkAKPTSFLDLNAS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 197 TPGSSswpthsqMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTI--VCKLQRNRLA--------------------- 253
Cdd:cd15320  156 LRDLT-------MDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIyrIAQKQIRRISaleraavhakncqnstgnrgs 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 254 ---------------KTKKPFKIIVTIIITFFLCWCPYHTLNLLEL---HHTAMPGSVFSLGLPLATALAIANSCMNPIL 315
Cdd:cd15320  229 gdcqqpessfkmsfkRETKVLKTLSVIMGVFVCCWLPFFILNCMVPfckPTSTEPFCISSTTFDVFVWFGWANSSLNPII 308
                        330
                 ....*....|
gi 215272319 316 YVFmGQDFKK 325
Cdd:cd15320  309 YAF-NADFRK 317
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
46-324 1.44e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 40.04  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVIIiATFKMKK--TVNMVWFLNLAVADFLFNVFLPIHiTYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15072    6 ILLVEALVGFSLNGLTIL-SFCKTRElrTPSNLLVLSLAVADMGISLNALVA-ASSSLLRRWPYGSEGCQAHGFQGFFTA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQnhrSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSW 203
Cdd:cd15072   84 LASICSSAAIAWDRYHHYCTRSKLQ---WSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDRNYVSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 204 pthsqmdpvgysrhmVVTVTRFlcGFLVPVLIITACYLTIVcklqrNRLAKTKKPFKIIVTIIITFFLCWCPYhtlNLLE 283
Cdd:cd15072  161 ---------------LFTMAFF--NFILPLFILLTSYSSIE-----QKLKKEGHLRFNTGLPLLTLLICWGPY---AILA 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 215272319 284 LHHTAMPGSVFSLGLPLATALAIANSC-MNPILYVFMGQDFK 324
Cdd:cd15072  216 LYAAITDVTSISPKLRMVPALLAKTSPtINAILYALGNENYR 257
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
46-171 1.53e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 39.67  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  46 VYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMF 124
Cdd:cd15066    5 AMTLIILAAIFGNLLVIIsVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 215272319 125 TSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLS 171
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALIS 131
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
79-325 1.90e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 39.54  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  79 LNLAVADFL-FNVFLPIHI-TYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLA 156
Cdd:cd15130   43 GSLALSDLLiLLLAMPVELyNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRT 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 157 YMACMVIWVLAFFLSSPSLVfrdtanlhgkISCFNNFSLSTPGSSSWPTHSQMDPVGYSrhmVVTVTRFLCGFLVPVLII 236
Cdd:cd15130  123 KKFISAIWLASALLAIPMLF----------TMGLQNESDDGTHPGGLVCTPIVDTATLK---VVIQVNTFMSFLFPMLVT 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 237 TACYLTIVCKLQRNrlakTKKPFKIIVTIIITFFLCWCPYHTLNLL-----ELHHTAMPGSVFSLGLPLATALAIANSCM 311
Cdd:cd15130  190 SILNTVIANKLVQA----LRRGVLVLRAVVIAFVVCWLPYHVRRLMfcyisDEQWTTFLFDFYHYFYMLTNALFYVSSAI 265
                        250
                 ....*....|....
gi 215272319 312 NPILYVFMGQDFKK 325
Cdd:cd15130  266 NPILYNLVSANFRQ 279
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
43-325 2.46e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 39.26  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  43 LVVVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIH 121
Cdd:cd15312    3 MYLFMAGAILLTVFGNLMVIIsISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 122 NMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSpSLVFRDtANLHG------KISCFNNFSL 195
Cdd:cd15312   83 LSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAF-GVVFSE-VNLEGiedyvaLVSCTGSCVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STpgSSSWpthsqmdpvgysrhmvvTVTRFLCGFLVPVLIITACYLTI--VCKLQ---------------RNRLAKTK-- 256
Cdd:cd15312  161 IF--NKLW-----------------GVIASLIAFFIPGTVMIGIYIKIffVARKHakvinnrpsvtkgdsKNKLSKKKer 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 257 KPFKIIVTIIITFFLCWCPYHTLNLLE-LHHTAMPGSVFSlglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15312  222 KAAKTLSIVMGVFLLCWLPFFVATLIDpFLNFSTPVDLFD----ALVWLGYFNSTCNPLIYGFFYPWFQK 287
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
45-325 3.75e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 38.73  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVII-IATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNM 123
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVaIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 124 FTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLV---FRDTANLHGKisCFNNfslstPGS 200
Cdd:cd15958   85 TASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMmhwWRDEDDQALK--CYED-----PGC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 201 SSWPTHSqmdpvgysrhmVVTVTRFLCGFLVPVLIITACYLTI---------------------------VCKLQRNRL- 252
Cdd:cd15958  158 CDFVTNR-----------AYAIASSIISFYIPLLIMIFVYLRVyreakkqikkidkcegrfhntltglgrKCKRRPSRIl 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215272319 253 -AKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAM-PGSVFSlglpLATALAIANSCMNPILYVfMGQDFKK 325
Cdd:cd15958  227 aLREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRELvPDWLFV----FFNWLGYANSAFNPIIYC-RSPDFRK 296
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
49-175 4.41e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 38.38  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNgLVIIIATFKMKK--TVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTS 126
Cdd:cd15214    8 IIAILICLGN-LVIVVTLYKKSYllTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSAS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 215272319 127 VFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSL 175
Cdd:cd15214   87 MLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPL 135
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
38-325 4.63e-03

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 38.61  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  38 VTRIFLVVVYSIVCFlgilGNGLVIIIATF-KMKKTVNMVWFLNLAVADFLFNVFLpIHITYAAMDYHWVFG-------- 108
Cdd:cd15966    2 ILRVFVWVMAFITCF----GNLFVIGMRSFiRAENKTHAMCIKILCCADCLMGVYL-FFVGIFDVKYRGEYNkyallwme 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 109 TAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPvWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT-ANLHGKI 187
Cdd:cd15966   77 SLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFP-FSNIRPGKCQTLIILISIWLVGFIIAVIPFWNEDFfGNYYGKN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 188 S-CFNNFSLSTPGSSSwpthsqmdpVGYSRHMvvtvtrFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTII 266
Cdd:cd15966  156 GvCFPLHSDQTEKIGA---------KGYSTGI------FLGLNLLAFIIIVFSYSSMFCSIQKTGLQTTEVRSHIHRDVA 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 267 ITF---------FLCWCPYHTLNLLELHHTAMPGSVFSLglpLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15966  221 VANrfffivfsdAICWIPIFLLKILSLFQVEIPGTITSW---IVIFILPINSALNPILYTLTTSFFKE 285
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
49-325 6.42e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 37.86  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  49 IVCFLGILGNGLVI-IIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSV 127
Cdd:cd15054    9 LIILLTVAGNSLLIlLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 128 FLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLvfrdtanlhgkiscfnNFSLSTPGSSSWPTHS 207
Cdd:cd15054   89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPI----------------ELGWHELGHERTLPNL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 208 QMDPVGYSRHMVVTVTRFLCG----FLVPVLIITACYLTIVcklqrnRLAKTK-KPFKIIVTIIITFFLCWCPYHTLNLL 282
Cdd:cd15054  153 TSGTVEGQCRLLVSLPYALVAscltFFLPSGAICFTYCRIL------LAARKAlKASLTLGILLGMFFVTWLPFFVANVV 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 215272319 283 ELHHTAMPGSVFSLglplATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15054  227 QAVCDCVSPGLFDV----LTWLGYCNSTMNPIIYPLFMRDFKR 265
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
45-325 8.62e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 37.55  E-value: 8.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  45 VVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFL-NLAVADFLF------NVFLPIHITYAAMDYHWVF--GTAMCKIS 115
Cdd:cd15346    5 VVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIgNLALSDLLAgvaytaNLLLSGATTYKLTPTQWFLreGSMFVALS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 116 nfllihnmfTSVFLLTIISSDRCISVLLPVWSQNHRSVRLaYMACMVIWVLAFFLSSPSLVFRDTanlhgkISCFNNFSL 195
Cdd:cd15346   85 ---------ASVFSLLAIAIERYITMLKMKLHNGSNSFRS-FLLISACWVISLILGGLPIMGWNC------ISALSSCST 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 196 STPGssswpthsqmdpvgYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQR------------NRLAKTKKPFKIIV 263
Cdd:cd15346  149 VLPL--------------YHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRrltfrknirkasRSSEKSMALLKTVI 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215272319 264 TIIITFFLCWCPYHTLNLLELHHTAMPGSVFsLGLPLATALAIANSCMNPILYVFMGQDFKK 325
Cdd:cd15346  215 IVLSVFIACWAPLFILLLLDVGCKVKTCSIL-FKAEYFLVLAVLNSATNPIIYTLTNKEMRR 275
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
80-325 8.79e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 37.70  E-value: 8.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  80 NLAVADFLFNVFLPIHITYAamdyhWVFGTAMCKISNFLLIHNMFT-SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYM 158
Cdd:cd15961   41 SLALADLLAGIGLILNFIFA-----YLLQSEAAKLVTVGLIVASFSaSVCSLLAITVDRYLSLYYALTYNSERTVTFTYV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 159 ACMVIWVLAFFLSSPSLVfrdtanlhgKISCFNNFSlstpgssswpTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITA 238
Cdd:cd15961  116 MLVLLWGASICLGLLPVM---------GWNCLADES----------TCSVVRPLTKNNAAILSVSFLLMFALMLQLYIQI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 239 CYLTI----VCKLQRNRLAK-----TKKPFKIIVTIIITFFLCWCPYhTLNLLELHHTAMPGSVFSLGLPlatalAIANS 309
Cdd:cd15961  177 CKIVMrhahQIALQHHFLATshyvtTRKGVSTLAIILGTFAACWMPF-TLYSLIADYTYPSIYTYATLLP-----ATYNS 250
                        250
                 ....*....|....*.
gi 215272319 310 CMNPILYVFMGQDFKK 325
Cdd:cd15961  251 IINPVIYAFRNQEIQK 266
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
80-325 9.35e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 37.45  E-value: 9.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  80 NLAVADFLFNVFLPIHITYAamdyhWVFGTAMCKISNFLLIHNMFT-SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYM 158
Cdd:cd15100   41 SLALADLLAGLGLILHFVFR-----YCVYSEALSLVSVGLLVAAFSaSVCSLLAITVDRYLSLYNALTYYSERTLTFTYV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 159 ACMVIWVLAFFLSS-PSLVFRdtaNLHGKISCfnnfslstpgssswpthSQMDPVGYSRHMVVTVTRFLCGFLVPVLIIT 237
Cdd:cd15100  116 MLALLWTLALGLGLlPVLGWN---CLREGSSC-----------------SVVRPLTKNHLAVLAVAFLLVFALMLQLYAQ 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319 238 ACylTIVCK------LQRNRLA-----KTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLgLPlatalAI 306
Cdd:cd15100  176 IC--RIVLRhahqiaLQRHFLApshyvATRKGVSTLALILGTFAACWIPFAVYCLLGDGSSPALYTYATL-LP-----AT 247
                        250
                 ....*....|....*....
gi 215272319 307 ANSCMNPILYVFMGQDFKK 325
Cdd:cd15100  248 YNSMINPIIYAFRNQDIQK 266
7tmA_GPR153_GPR162-like cd14998
orphan G protein-coupled receptors 153 and 162, member of the class A family of ...
53-182 9.72e-03

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320129  Cd Length: 301  Bit Score: 37.61  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215272319  53 LGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIhITYA-------AMDYHWVFGTAMCKISNFLLIhnMFT 125
Cdd:cd14998   13 LSLLANAWGILSISAKQQKHKPLELLLCFLAGTHMLMVAVPL-TTYSvvqlrrqASDYDWNEGLCKVFVSTFYTL--TLA 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 215272319 126 SVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSS-PSLVFRDTAN 182
Cdd:cd14998   90 TCFTVTSLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTlPSIGWHDNSE 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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