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Conserved domains on  [gi|21361787|ref|NP_060729|]
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tetratricopeptide repeat protein 17 isoform 1 precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 5.51e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457   36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457  111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 1.48e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457   33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457  110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.18e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457   43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457  120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                        170       180
                 ....*....|....*....|..
gi 21361787  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457  200 LLALEQALRKKLAILTLAALAE 221
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 5.51e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457   36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457  111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 1.48e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457   33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457  110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.18e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457   43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457  120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                        170       180
                 ....*....|....*....|..
gi 21361787  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457  200 LLALEQALRKKLAILTLAALAE 221
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-738 2.69e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    573 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    638 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 21361787    718 LttkcpECENSLKLIRCMQFY 738
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 9.72e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 9.72e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21361787    658 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 4.81e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269  207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                 ....*
gi 21361787  406 LGNHQ 410
Cdd:cd16269  287 IRSLK 291
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 982-1116 1.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    982 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1060
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 21361787   1061 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1116
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 1.79e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 21361787     689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_1 pfam00515
Tetratricopeptide repeat;
1088-1118 3.16e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21361787   1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1088-1118 3.53e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.53e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 21361787    1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 7.59e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 21361787    297 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 5.51e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457   36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457  111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-729 7.94e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 7.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457    2 ELDPDDAEAYNNL---GLAYRRLGRYEEAIEDYEKALELDPDDAE--ALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSL 729
Cdd:COG0457   77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1132 1.48e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457   33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1132
Cdd:COG0457  110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 621-724 1.60e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 700
Cdd:COG3914   80 LLELAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR 157

                         90       100
                 ....*....|....*....|....
gi 21361787  701 ALKNISGALEAFRQALKLTTKCPE 724
Cdd:COG3914  158 RLGRLEEAIAALRRALELDPDNAE 181
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 610-718 4.60e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 4.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG3914  106 ALNPDNAEALFNLGNL---LLALGRLEEALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                         90       100
                 ....*....|....*....|....*....
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAYRRALEL 209
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1015-1121 4.90e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.26  E-value: 4.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1015 WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNV 1094
Cdd:COG0457    9 EAYNNLGLAYRR-LGRYEEAIEDYEKALELDPDD--AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                         90       100
                 ....*....|....*....|....*..
gi 21361787 1095 YVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG0457   86 LQALGRYEEALEDYDKALELDPDDAEA 112
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 615-718 7.15e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.79  E-value: 7.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  615 NAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 694
Cdd:COG4235   16 DAEGWLLL---GRAYLRLGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                         90       100
                 ....*....|....*....|....
gi 21361787  695 LGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4235   91 LGLAAFQQGDYAEAIAAWQKLLAL 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1006-1121 9.57e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 9.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG2956   67 KLLERDpDRAEALLELAQDYLK-AGLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 960-1121 1.33e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.32  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  960 LDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIgtriakvLEKN-QTSWVLSSMAALYwRVKGQGKKAIDCL 1038
Cdd:COG3914   64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRA-------LALNpDNAEALFNLGNLL-LALGRLEEALAAL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1039 RQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:COG3914  136 RRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213


                 ...
gi 21361787 1119 VPA 1121
Cdd:COG3914  214 ADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 622-724 1.83e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDP--DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100
                 ....*....|....*....|...
gi 21361787  702 LKNISGALEAFRQALKLTTKCPE 724
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHPE 107
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 977-1128 2.20e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  977 ESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYwRVKGQGKKAIDCLRQALHYAPHQMkdVPLI 1055
Cdd:COG2956   72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaEALRLLAEIY-EQEGDWEKAIEVLERLLKLGPENA--HAYC 148

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21361787 1056 SLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTI 1128
Cdd:COG2956  149 ELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 633-718 2.58e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.28  E-value: 2.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  633 GNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAF 712
Cdd:COG5010   68 GDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145


                 ....*.
gi 21361787  713 RQALKL 718
Cdd:COG5010  146 QRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 978-1118 5.76e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.58  E-value: 5.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  978 SQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLIS 1056
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNpEAFALLGEILLQ-LGDLDEAIVLLHEALELDPDE--PEARLN 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21361787 1057 LANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1020-1125 9.34e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 9.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1020 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1099
Cdd:COG3914   83 LAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160

                         90       100
                 ....*....|....*....|....*.
gi 21361787 1100 EFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG3914  161 RLEEAIAALRRALELDPDNAEALNNL 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1022-1128 1.58e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1022 ALYWRVKGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1101
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKALELDPDNP--EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                         90       100
                 ....*....|....*....|....*..
gi 21361787 1102 EKALVWYESTLKLQPEFVPAKNRIQTI 1128
Cdd:COG4783   89 DEALALLEKALKLDPEHPEAYLRLARA 115
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
615-724 1.92e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  615 NAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 694
Cdd:COG4785   69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAE--AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                         90       100       110
                 ....*....|....*....|....*....|
gi 21361787  695 LGNAYLALKNISGALEAFRQALKLTTKCPE 724
Cdd:COG4785  147 RGIALYYLGRYELAIADLEKALELDPNDPE 176
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
621-717 4.83e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 700
Cdd:COG0457   78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                         90
                 ....*....|....*..
gi 21361787  701 ALKNISGALEAFRQALK 717
Cdd:COG0457  156 KLGRYEEALELLEKLEA 172
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
628-719 6.62e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 6.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  628 YWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLlQALAINSSEPLTFLSLGNAYLALKNISG 707
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNAD--ALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|..
gi 21361787  708 ALEAFRQALKLT 719
Cdd:COG3063   78 ALAYLERALELD 89
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1028-1117 6.68e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 6.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1028 KGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAvIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1107
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNA--DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                         90
                 ....*....|
gi 21361787 1108 YESTLKLQPE 1117
Cdd:COG3063   82 LERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1010-1121 2.12e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1010 KNQTSWVLssMAALYWRvKGQGKKAIDCLRQALHYAPhQMKDVpLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHF 1089
Cdd:COG4235   15 NDAEGWLL--LGRAYLR-LGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALY 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 21361787 1090 TLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG4235   90 LLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 638-718 3.02e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  638 AIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG4783   57 AIVLLHEALELDPDEPE--ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134


                 .
gi 21361787  718 L 718
Cdd:COG4783  135 L 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1054-1125 3.93e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 3.93e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21361787 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1028-1116 4.25e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1028 KGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1107
Cdd:COG5010   67 LGDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                 ....*....
gi 21361787 1108 YESTLKLQP 1116
Cdd:COG5010  145 LQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1006-1117 7.99e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 7.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHqmKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG2956   33 EALELDpETVEAHLALGNLYRR-RGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                         90       100       110
                 ....*....|....*....|....*....|...
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPE 1117
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1006-1126 1.05e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1006 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1084
Cdd:COG0457   67 QALELDpDDAEALNNLGLALQA-LGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 21361787 1085 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQ 1126
Cdd:COG0457  144 ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.18e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457   43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457  120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                        170       180
                 ....*....|....*....|..
gi 21361787  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457  200 LLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1033-1121 1.34e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1033 KAIDCLRQALHYAPhqmKDVP-LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYEST 1111
Cdd:COG4235    1 EAIARLRQALAANP---NDAEgWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                         90
                 ....*....|
gi 21361787 1112 LKLQPEFVPA 1121
Cdd:COG4235   78 LALDPDNPEA 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1020-1136 1.48e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1020 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1099
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVE--AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 21361787 1100 EFEKALVWYESTLKLQPEFVPAKNRIqtIQCHLMLKK 1136
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAEALRLL--AEIYEQEGD 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 609-725 1.50e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  609 HAINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSE 688
Cdd:COG2956   35 LELDPETVEAHLAL--GNLYRRR-GEYDRAIRIHQKLLERDPDRAE--ALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 21361787  689 PLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPEC 725
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 622-718 3.85e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDvplvnlANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG3914   51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELA------ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                         90
                 ....*....|....*..
gi 21361787  702 LKNISGALEAFRQALKL 718
Cdd:COG3914  125 LGRLEEALAALRRALAL 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 638-718 5.76e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  638 AIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG2956  129 AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206


                 .
gi 21361787  718 L 718
Cdd:COG2956  207 Q 207
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 610-719 1.15e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPlqyQDVP-LVNLANLLIHYGLHLDATKLLLQALAINSSE 688
Cdd:COG2956  138 KLGPENAHAYCEL--AELYLEQ-GDYDEAIEALEKALKLDP---DCARaLLLLAELYLEQGDYEEAIAALERALEQDPDY 211

                         90       100       110
                 ....*....|....*....|....*....|.
gi 21361787  689 PLTFLSLGNAYLALKNISGALEAFRQALKLT 719
Cdd:COG2956  212 LPALPRLAELYEKLGDPEEALELLRKALELD 242
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 625-724 1.79e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  625 AGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKN 704
Cdd:COG2956   83 AQDYLKA-GLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                         90       100
                 ....*....|....*....|
gi 21361787  705 ISGALEAFRQALKLTTKCPE 724
Cdd:COG2956  160 YDEAIEALEKALKLDPDCAR 179
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-738 2.69e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    573 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    638 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 21361787    718 LttkcpECENSLKLIRCMQFY 738
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 622-736 3.72e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG5010   21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSR 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 21361787  702 LKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG5010  101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
643-718 5.30e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 5.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21361787  643 QRALNLAPLQYqdvplvNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4785   67 LALPDLAQLYY------ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL 136
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1054-1121 6.14e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 6.14e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21361787 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1121
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 9.72e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 9.72e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21361787    658 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 610-727 4.09e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG3914  140 ALNPDFAEAYLNLGEA---LRRLGRLEEAIAALRRALELDP-DNAEA-LNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 21361787  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN 727
Cdd:COG3914  215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSP 252
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 4.81e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269  207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                 ....*
gi 21361787  406 LGNHQ 410
Cdd:cd16269  287 IRSLK 291
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 673-718 6.46e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 6.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 21361787  673 DATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL 46
ClassIIa_HDAC5_Gln-rich-N cd10164
Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This ...
 338-424 7.23e-04

Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This family consists of the glutamine-rich domain of histone deacetylase 5 (HDAC5). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197400 [Multi-domain]  Cd Length: 97  Bit Score: 40.19  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  338 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEI-LEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRL 414
Cdd:cd10164    3 SLREQQLQQELLLlkQQQQLQKQL-LFAEFQKQHEHLTRQHEVqLQKHLKVRAELFSEQQQQEILAAKRQQELEQQRKRE 81

                         90
                 ....*....|
gi 21361787  415 VNQQHSLHCQ 424
Cdd:cd10164   82 QQRQEELEKQ 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1059-1123 7.54e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 7.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361787 1059 NILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKN 1123
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 982-1116 1.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787    982 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1060
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 21361787   1061 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1116
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 1.79e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 21361787     689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1054-1138 1.88e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787 1054 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIqtiqCHLM 1133
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL----GLAL 82


                 ....*
gi 21361787 1134 LKKGR 1138
Cdd:COG4783   83 LKAGD 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1004-1122 2.25e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787   1004 IAKVLE---KNQTSWVLSsmaALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEI 1080
Cdd:TIGR02917  182 IDEVLTadpGNVDALLLK---GDLLLSLGNIELALAAYRKAIALRPNNIA--VLLALATILIEAGEFEEAEKHADALLKK 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 21361787   1081 APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAK 1122
Cdd:TIGR02917  257 APNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPAL 298
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1078-1125 2.43e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 21361787 1078 VEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1125
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
TPR_1 pfam00515
Tetratricopeptide repeat;
1088-1118 3.16e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21361787   1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1088-1118 3.53e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.53e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 21361787    1088 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1118
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
689-718 4.08e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 4.08e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 21361787    689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 610-717 4.29e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG2956  172 KLDPDCARALLLL---AELYLEQGDYEEAIAALERALEQDP-DYLPA-LPRLAELYEKLGDPEEALELLRKALELDPSDD 246

                         90       100
                 ....*....|....*....|....*...
gi 21361787  690 LtFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG2956  247 L-LLALADLLERKEGLEAALALLERQLR 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-356 4.98e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 4.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21361787  291 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQ-KLEQKLEAQHRSLQ 356
Cdd:COG0457    4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLgRYEEALADYEQALE 70
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 7.59e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 21361787    297 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 695-718 7.95e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.19  E-value: 7.95e-03
                           10        20
                   ....*....|....*....|....
gi 21361787    695 LGNAYLALKNISGALEAFRQALKL 718
Cdd:pfam07719    7 LGLAYYKLGDYEEALEAYEKALEL 30
ClassIIa_HDAC_Gln-rich-N cd10149
Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, ...
 338-419 8.89e-03

Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); This superfamily consists of a glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDAC9; it is missing in HDAC7. It is referred to as the glutamine-rich domain, and confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors. This domain is able to repress transcription independently of the HDAC's C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197397 [Multi-domain]  Cd Length: 90  Bit Score: 36.59  E-value: 8.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  338 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLV 415
Cdd:cd10149    3 VLREQQLQQELLAlkQQQQIQKQL-LIAEFQKQHENLTRQHEAQLQEHIKQQQEMLAIKQQQELLEKQRKLEQQRQEQEL 81


                 ....
gi 21361787  416 NQQH 419
Cdd:cd10149   82 EKQR 85
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1022-1122 8.97e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 8.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787   1022 ALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLisLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1101
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNY 651

                           90       100
                   ....*....|....*....|.
gi 21361787   1102 EKALVWYESTLKLQPEFVPAK 1122
Cdd:TIGR02917  652 AKAITSLKRALELKPDNTEAQ 672
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-378 9.84e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 9.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  291 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQK--------LEQKLEAQ------HRSLQ 356
Cdd:COG0457   38 DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGryeealedYDKALELDpddaeaLYNLG 117

                         90       100
                 ....*....|....*....|..
gi 21361787  357 RTLNELKEYQKQHDHYLRQQEI 378
Cdd:COG0457  118 LALLELGRYDEAIEAYERALEL 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 172-385 9.89e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 9.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  172 AFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHeGLQKN-TSSWVLYNMASFYwRIKNEPYQVVECAM 250
Cdd:COG3914   59 LLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRR-ALALNpDNAEALFNLGNLL-LALGRLEEALAALR 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361787  251 RALHFSSRHNKdiALVNLANVLHRAH-FSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFE 329
Cdd:COG3914  137 RALALNPDFAE--AYLNLGEALRRLGrLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21361787  330 QAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQ---QEILEKHKLI 385
Cdd:COG3914  215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDddpAELLALARAW 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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