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Conserved domains on  [gi|21361503|ref|NP_057032|]
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adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1 [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 12093821)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; such as yeast UDP-N-acetylglucosamine transporter YEA4 and vertebrate UDP-xylose and UDP-N-acetylglucosamine transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 80-371 7.47e-103

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 306.92  E-value: 7.47e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503    80 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 155
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   156 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 227
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   228 GVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLgltCTSGLGPAVTFCAKNPVRTY-------GYA 300
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLL---LQGDLFSAVQFCSQSPDKAVlslpsmlFYL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21361503   301 FLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 371
Cdd:pfam08449 237 LLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 80-371 7.47e-103

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 306.92  E-value: 7.47e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503    80 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 155
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   156 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 227
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   228 GVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLgltCTSGLGPAVTFCAKNPVRTY-------GYA 300
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLL---LQGDLFSAVQFCSQSPDKAVlslpsmlFYL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21361503   301 FLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 371
Cdd:pfam08449 237 LLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 113-371 9.77e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 40.60  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 113 WYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQG 192
Cdd:COG0697  36 FLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLG 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 193 KRYNVADVSAAICMSLGLIWFTLADSTTAPNFNL-TGVVLISLALCAdavIGNVQEKAMkLHNASNSEMVLYSYSIGFVY 271
Cdd:COG0697 116 ERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLgDLLALLAALSWA---LYTVLTRRL-SRRLDPLTLTFWQMLVGALL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 272 ILLGLTCTSGLGPAvtfcaknPVRTYGYAFLFSLTGY-FGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFT 350
Cdd:COG0697 192 LLPLALLTGLPLPL-------SAAAWLALLYLGLFGTaLAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLT 264

                       250       260
                ....*....|....*....|.
gi 21361503 351 FQYVWSGLLVVLGIFLNVYSK 371
Cdd:COG0697 265 PLQLLGAALILAGVLLAALRE 285
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 80-371 7.47e-103

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 306.92  E-value: 7.47e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503    80 QFFICVAGVFVFYLIYGYLQELIFSVEGfKSCGWYLTLVQFAFYSIFGLIELQLI----QDKRRRIPGKTYMIIAFLTVG 155
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDIftskFLKPRKIPLKTYVILVALFFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   156 TMGLSNTSLGY-LNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTL-------ADSTTAPNFNLT 227
Cdd:pfam08449  80 TSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSVVSPNFFLI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503   228 GVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLgltCTSGLGPAVTFCAKNPVRTY-------GYA 300
Cdd:pfam08449 160 GIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLL---LQGDLFSAVQFCSQSPDKAVlslpsmlFYL 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21361503   301 FLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSK 371
Cdd:pfam08449 237 LLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 113-371 9.77e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 40.60  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 113 WYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQG 192
Cdd:COG0697  36 FLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLG 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 193 KRYNVADVSAAICMSLGLIWFTLADSTTAPNFNL-TGVVLISLALCAdavIGNVQEKAMkLHNASNSEMVLYSYSIGFVY 271
Cdd:COG0697 116 ERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLgDLLALLAALSWA---LYTVLTRRL-SRRLDPLTLTFWQMLVGALL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 272 ILLGLTCTSGLGPAvtfcaknPVRTYGYAFLFSLTGY-FGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFT 350
Cdd:COG0697 192 LLPLALLTGLPLPL-------SAAAWLALLYLGLFGTaLAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLT 264

                       250       260
                ....*....|....*....|.
gi 21361503 351 FQYVWSGLLVVLGIFLNVYSK 371
Cdd:COG0697 265 PLQLLGAALILAGVLLAALRE 285
VRG4 COG5070
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
 139-379 3.90e-03

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227402  Cd Length: 309  Bit Score: 39.10  E-value: 3.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 139 RRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADS 218
Cdd:COG5070  64 RLTKAKKWFPISFLLVVMIYTSSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGRVTSLELLSFILMVLSSVVATWGDQ 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 219 TTAPNFNLT---GVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTfcAKNPVR 295
Cdd:COG5070 144 QASAFKAQIlnpGYLWMFTNCLSSAAFVLIMRKRIKLTNFKDFDTMFYNNLLSLPILLSFSFLFEDWSPGNL--ANNLSV 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361503 296 TYGYAFLFSLTGYFGISFVLA-LIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMD 374
Cdd:COG5070 222 DSLMAMFISGLCSVGISYCSAwCVRVTSSTTYSMVGALNKLPIALAGLVFFDAPVNFLSIFSILLGFLSGAIYAVAKSKK 301


                ....*
gi 21361503 375 KIRLP 379
Cdd:COG5070 302 QQNQK 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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