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Conserved domains on  [gi|213516201|gb|ACJ49577|]
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cytochrome b, partial (mitochondrion) [Cheirogaleus major]

Protein Classification

cytochrome b( domain architecture ID 999999)

cytochrome b is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain; contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis

CATH:  1.20.810.10
Gene Ontology:  GO:0009055|GO:0046872|GO:0022904|GO:0005743|GO:0020037
PubMed:  2509716|8329437
SCOP:  4002208

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYTB super family cl31797
cytochrome b; Provisional
 1-80 2.08e-56

cytochrome b; Provisional


The actual alignment was detected with superfamily member MTH00100:

Pssm-ID: 177162 [Multi-domain]  Cd Length: 379  Bit Score: 177.14  E-value: 2.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00100  79 IRYLHANGASMFFICLFLHVGRGLYYGSYLFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 158
 
Name Accession Description Interval E-value
CYTB MTH00100
cytochrome b; Provisional
 1-80 2.08e-56

cytochrome b; Provisional


Pssm-ID: 177162 [Multi-domain]  Cd Length: 379  Bit Score: 177.14  E-value: 2.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00100  79 IRYLHANGASMFFICLFLHVGRGLYYGSYLFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 158
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-80 1.33e-31

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 108.61  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSF--TMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:cd00284   71 IRSLHANGASMFFLMLYLHIFRGLYYGSYkkPRELTWVIGVILLLLTMATAFMGYVLPWGQMSYWGATVITNLFSAIPVI 150


                 ..
gi 213516201  79 GT 80
Cdd:cd00284  151 GI 152
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-80 5.80e-29

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 106.03  E-value: 5.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSE--TWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:COG1290   88 IRYMHHWGASLFFAAVYLHMFRGFFYGAYKKPRelNWIIGVLLLLLTMAEAFTGYSLPWDQLSYWGARVITGLFGAIPVI 167


                 ..
gi 213516201  79 GT 80
Cdd:COG1290  168 GT 169
Cytochrome_B pfam00033
Cytochrome b/b6/petB;
1-80 1.04e-28

Cytochrome b/b6/petB;


Pssm-ID: 306530  Cd Length: 189  Bit Score: 100.92  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201    1 IRYLHANGASMFFLCLFIHVGRGMYYGSF--TMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:pfam00033  62 IRSVHANGASMFFLMLYLHIFRGLYYGGFsyPRELTWVIGVILLVLTMSTAFIGYVLPWGQMSYWGATVITNLLSAIPVI 141


                  ..
gi 213516201   79 GT 80
Cdd:pfam00033 142 GD 143
 
Name Accession Description Interval E-value
CYTB MTH00100
cytochrome b; Provisional
 1-80 2.08e-56

cytochrome b; Provisional


Pssm-ID: 177162 [Multi-domain]  Cd Length: 379  Bit Score: 177.14  E-value: 2.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00100  79 IRYLHANGASMFFICLFLHVGRGLYYGSYLFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 158
CYTB MTH00119
cytochrome b; Provisional
 1-80 2.35e-49

cytochrome b; Provisional


Pssm-ID: 214425 [Multi-domain]  Cd Length: 380  Bit Score: 159.30  E-value: 2.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00119  80 IRNLHANGASMFFICIYLHIGRGLYYGSYLYKETWNTGVILLLLLMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGQ 159
CYTB MTH00156
cytochrome b; Provisional
 1-80 1.23e-48

cytochrome b; Provisional


Pssm-ID: 214440 [Multi-domain]  Cd Length: 356  Bit Score: 156.48  E-value: 1.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00156  69 LRTLHANGASFFFICIYLHIGRGIYYGSYKLKHTWMSGVIILFLVMATAFLGYVLPWGQMSFWGATVITNLLSAIPYLGT 148
CYTB MTH00074
cytochrome b; Provisional
 1-80 3.77e-47

cytochrome b; Provisional


Pssm-ID: 177145 [Multi-domain]  Cd Length: 380  Bit Score: 153.30  E-value: 3.77e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00074  80 MRNIHANGASFFFICIYLHIGRGLYYGSYMYKETWNIGVILLFLVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYMGD 159
CYTB MTH00145
cytochrome b; Provisional
 1-79 2.86e-46

cytochrome b; Provisional


Pssm-ID: 177203 [Multi-domain]  Cd Length: 379  Bit Score: 151.21  E-value: 2.86e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIG 79
Cdd:MTH00145  80 LRSLHANGASFFFICIYLHIGRGLYYGSYLMQHTWNIGVTLLLLSMGTAFLGYVLPWGQMSFWGATVITNLLSAIPYVG 158
CYTB MTH00131
cytochrome b; Provisional
 1-79 2.33e-45

cytochrome b; Provisional


Pssm-ID: 177189 [Multi-domain]  Cd Length: 380  Bit Score: 148.65  E-value: 2.33e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIG 79
Cdd:MTH00131  79 IRNLHANGASFFFICIYLHIGRGLYYGSYLYKETWNIGVVLLLLVMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVG 157
CYTB MTH00191
cytochrome b; Provisional
 1-80 6.14e-45

cytochrome b; Provisional


Pssm-ID: 177239 [Multi-domain]  Cd Length: 365  Bit Score: 147.37  E-value: 6.14e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00191  76 LRNIHANGASFFFICIYLHIGRGLYYGSYLNKETWNVGVILLILSMATAFLGYVLPWGQMSFWGATVITNLLSAIPYIGD 155
CYTB MTH00016
cytochrome b; Validated
 1-81 1.27e-43

cytochrome b; Validated


Pssm-ID: 177102 [Multi-domain]  Cd Length: 378  Bit Score: 144.43  E-value: 1.27e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00016  80 LRNLHANGASFFFICLYLHIGRGIYYGSYFLMETWNIGVILLLLTMATAFLGYVLPWGQMSFWGATVITNLLSAIPYIGK 159


                 .
gi 213516201  81 I 81
Cdd:MTH00016 160 M 160
CYTB MTH00034
cytochrome b; Validated
 1-80 1.16e-41

cytochrome b; Validated


Pssm-ID: 177109 [Multi-domain]  Cd Length: 379  Bit Score: 139.07  E-value: 1.16e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00034  79 LRNIHANGASLFFICLYFHIGRGLYYGSYVNIETWNIGVILFLLTMLTAFVGYVLPWGQMSFWAATVITNLVSAVPYIGT 158
CYTB MTH00022
cytochrome b; Validated
 1-80 4.90e-40

cytochrome b; Validated


Pssm-ID: 164595 [Multi-domain]  Cd Length: 379  Bit Score: 134.83  E-value: 4.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00022  78 LRYLHANGASLFFLCLYIHIGRGLYYGGYLKFHVWNVGVVIFLLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGT 157
CYTB MTH00224
cytochrome b; Provisional
 1-79 1.03e-38

cytochrome b; Provisional


Pssm-ID: 164767 [Multi-domain]  Cd Length: 379  Bit Score: 131.58  E-value: 1.03e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIG 79
Cdd:MTH00224  80 LRSIHANGASMFFLFIYLHVGRGLYYGSFNLSETWNIGVILFILTMATAFLGYVLPWGQMSFWGATVITNLFSAIPYIG 158
CYTB MTH00053
cytochrome b; Provisional
 1-79 1.18e-37

cytochrome b; Provisional


Pssm-ID: 164624 [Multi-domain]  Cd Length: 381  Bit Score: 128.67  E-value: 1.18e-37
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIG 79
Cdd:MTH00053  80 LRYLHANGASMFFLCVYFHIGRGIYYGSYTKIIVWNVGVLIFLLMILTAFIGYVLPWGQMSFWAATVITNLLSAIPYVG 158
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-80 1.33e-31

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 108.61  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSF--TMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:cd00284   71 IRSLHANGASMFFLMLYLHIFRGLYYGSYkkPRELTWVIGVILLLLTMATAFMGYVLPWGQMSYWGATVITNLFSAIPVI 150


                 ..
gi 213516201  79 GT 80
Cdd:cd00284  151 GI 152
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-80 5.80e-29

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 106.03  E-value: 5.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSE--TWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:COG1290   88 IRYMHHWGASLFFAAVYLHMFRGFFYGAYKKPRelNWIIGVLLLLLTMAEAFTGYSLPWDQLSYWGARVITGLFGAIPVI 167


                 ..
gi 213516201  79 GT 80
Cdd:COG1290  168 GT 169
Cytochrome_B pfam00033
Cytochrome b/b6/petB;
1-80 1.04e-28

Cytochrome b/b6/petB;


Pssm-ID: 306530  Cd Length: 189  Bit Score: 100.92  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201    1 IRYLHANGASMFFLCLFIHVGRGMYYGSF--TMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:pfam00033  62 IRSVHANGASMFFLMLYLHIFRGLYYGGFsyPRELTWVIGVILLVLTMSTAFIGYVLPWGQMSYWGATVITNLLSAIPVI 141


                  ..
gi 213516201   79 GT 80
Cdd:pfam00033 142 GD 143
CYTB MTH00033
cytochrome b; Provisional
 1-80 9.23e-28

cytochrome b; Provisional


Pssm-ID: 133672 [Multi-domain]  Cd Length: 383  Bit Score: 102.71  E-value: 9.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00033  76 LRYVHANGASLFFICVYCHIGRGLYYGGYSRVLTWIVGVLIFFIMMLTAFIGYVLPWGQMSFWAATVITNLVSAIPSVGG 155
CYTB MTH00086
cytochrome b; Provisional
 1-79 2.47e-25

cytochrome b; Provisional


Pssm-ID: 177151 [Multi-domain]  Cd Length: 355  Bit Score: 95.78  E-value: 2.47e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIG 79
Cdd:MTH00086  68 FRIFHFNGASLFFIFLYLHIFKGLFMMSYRLKKVWISGLTIYLLVMMEAFMGYVLVWAQMSFWAAVVITSLLSVIPIWG 146
CYTB MTH00046
cytochrome b; Validated
 1-81 1.68e-23

cytochrome b; Validated


Pssm-ID: 177121 [Multi-domain]  Cd Length: 355  Bit Score: 90.81  E-value: 1.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:MTH00046  70 VRYWHIWGVNVLFILLFIHMGRALYYSSYSKKGVWNVGFILYLLVMVEAFLGYILPWHQMSYWAATVLTSIVDSVPIVGS 149


                 .
gi 213516201  81 I 81
Cdd:MTH00046 150 L 150
Cytochrom_B_N_2 pfam13631
Cytochrome b(N-terminal)/b6/petB;
10-80 1.05e-15

Cytochrome b(N-terminal)/b6/petB;


Pssm-ID: 433364  Cd Length: 169  Bit Score: 67.27  E-value: 1.05e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 213516201   10 SMFFLCLFIHVGRGMYYGSF--TMSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGT 80
Cdd:pfam13631   1 YIFIAAIYVHMLRIFFTGAYrkPRELNWIIGVLLLLLTLGEGFTGYSLPDDLLSGTGLRIGLGILSSIPVVGT 73
PRK03735 PRK03735
cytochrome b6; Provisional
 1-79 2.26e-11

cytochrome b6; Provisional


Pssm-ID: 179639  Cd Length: 223  Bit Score: 56.64  E-value: 2.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSE--TWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:PRK03735  90 VRGMHHWGASLVIVMMFLHTLRVFFTGGYKKPRelNWVVGVLIFFVTVGLGFTGYLLPWDQKAYFATKVGSQIAEAIPVI 169


                 .
gi 213516201  79 G 79
Cdd:PRK03735 170 G 170
petB CHL00070
cytochrome b6
 1-79 1.13e-08

cytochrome b6


Pssm-ID: 177009  Cd Length: 215  Bit Score: 49.33  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213516201   1 IRYLHANGASMFFLCLFIHVGRGMYYGSFTMSE--TWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYI 78
Cdd:CHL00070  82 IRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRelTWVTGVVLAVLTVSFGVTGYSLPWDQIGYWAVKIVTGVPEAIPVI 161


                 .
gi 213516201  79 G 79
Cdd:CHL00070 162 G 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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