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Conserved domains on  [gi|2131399688|ref|NP_990499|]
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secreted phosphoprotein 24 isoform 2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cathelicidins super family cl29764
Cathelicidin; A novel protein family, showing a conserved proregion and a variable ...
3-63 5.63e-18

Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.


The actual alignment was detected with superfamily member pfam07448:

Pssm-ID: 453055  Cd Length: 64  Bit Score: 71.77  E-value: 5.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399688   3 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 63
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63
 
Name Accession Description Interval E-value
Spp-24 pfam07448
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ...
3-63 5.63e-18

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.


Pssm-ID: 429466  Cd Length: 64  Bit Score: 71.77  E-value: 5.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399688   3 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 63
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63
 
Name Accession Description Interval E-value
Spp-24 pfam07448
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved ...
3-63 5.63e-18

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.


Pssm-ID: 429466  Cd Length: 64  Bit Score: 71.77  E-value: 5.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399688   3 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 63
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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