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Conserved domains on  [gi|2130696768|gb|KAH7639218|]
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sushi domain containing protein 2 [Dermatophagoides farinae]

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 12867676)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 307-422 1.66e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130696768 307 VDGSRSVEYHCHDGYRLIGQSRRHCD-QRTGQ--WIDKEPYCERITCPEPVSIMNGFHRMYgEDYYDQpvvGSRTVYECR 383
Cdd:PHA02927  102 VDFGSSITYSCNSGYQLIGESKSYCElGSTGSmvWNPEAPICESVKCQSPPSISNGRHNGY-EDFYTD---GSVVTYSCN 177

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2130696768 384 PGFVFVdpnANDTRICDRyGQWSgslDVPQCEPIDCGHP 422
Cdd:PHA02927  178 SGYSLI---GNSGVLCSG-GEWS---DPPTCQIVKCPHP 209
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 59-114 2.82e-17

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 76.35  E-value: 2.82e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 307-422 1.66e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130696768 307 VDGSRSVEYHCHDGYRLIGQSRRHCD-QRTGQ--WIDKEPYCERITCPEPVSIMNGFHRMYgEDYYDQpvvGSRTVYECR 383
Cdd:PHA02927  102 VDFGSSITYSCNSGYQLIGESKSYCElGSTGSmvWNPEAPICESVKCQSPPSISNGRHNGY-EDFYTD---GSVVTYSCN 177

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2130696768 384 PGFVFVdpnANDTRICDRyGQWSgslDVPQCEPIDCGHP 422
Cdd:PHA02927  178 SGYSLI---GNSGVLCSG-GEWS---DPPTCQIVKCPHP 209
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 59-114 2.82e-17

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 76.35  E-value: 2.82e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-114 8.15e-16

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 72.17  E-value: 8.15e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768   59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
59-114 8.24e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 63.67  E-value: 8.24e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 350-414 9.94e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 9.94e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2130696768  350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQC 414
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYS----YGDTVTYSCDPGYTLIGSS---TITCLENGTWSPP--PPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 350-415 1.35e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.00  E-value: 1.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768 350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQCE 415
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYS----YGSTVTYSCNEGYTLVGSS---TITCTENGGWSPP--PPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
350-414 3.13e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 3.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2130696768 350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQC 414
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYN----YGASVSYECDPGYRLVGSP---TITCQEDGTWSPP--FPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 59-114 1.52e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.12  E-value: 1.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTC---QSNNTWSGRMPIC 114
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFC 80
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 307-422 1.66e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130696768 307 VDGSRSVEYHCHDGYRLIGQSRRHCD-QRTGQ--WIDKEPYCERITCPEPVSIMNGFHRMYgEDYYDQpvvGSRTVYECR 383
Cdd:PHA02927  102 VDFGSSITYSCNSGYQLIGESKSYCElGSTGSmvWNPEAPICESVKCQSPPSISNGRHNGY-EDFYTD---GSVVTYSCN 177

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2130696768 384 PGFVFVdpnANDTRICDRyGQWSgslDVPQCEPIDCGHP 422
Cdd:PHA02927  178 SGYSLI---GNSGVLCSG-GEWS---DPPTCQIVKCPHP 209
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 59-114 2.82e-17

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 76.35  E-value: 2.82e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-114 8.15e-16

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 72.17  E-value: 8.15e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768   59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
59-114 8.24e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 63.67  E-value: 8.24e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 350-414 9.94e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 9.94e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2130696768  350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQC 414
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYS----YGDTVTYSCDPGYTLIGSS---TITCLENGTWSPP--PPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 350-415 1.35e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.00  E-value: 1.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130696768 350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQCE 415
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYS----YGSTVTYSCNEGYTLVGSS---TITCTENGGWSPP--PPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 289-346 2.73e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.23  E-value: 2.73e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2130696768 289 CGQVEVPAFGFVLDQQISVDGSRSVEYHCHDGYRLIGQSRRHCdQRTGQWIDKEPYCE 346
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC-TENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
350-414 3.13e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 3.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2130696768 350 CPEPVSIMNGFHRMYGEDYYdqpvVGSRTVYECRPGFVFVDPNandTRICDRYGQWSGSldVPQC 414
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYN----YGASVSYECDPGYRLVGSP---TITCQEDGTWSPP--FPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 289-345 9.96e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 46.75  E-value: 9.96e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2130696768  289 CGQVEVPAFGFVLDQQISVDGSRSVEYHCHDGYRLIGQSRRHCdQRTGQWIDKEPYC 345
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITC-LENGTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 298-422 8.38e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.89  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130696768 298 GFVLDQQISVDGSRSVEYHCHDGYRLIGQSRRHC--DQRTGQWIDKEPYCERITCPEPVSIMNGfhRMYGEDyyDQPVVG 375
Cdd:PHA02639   31 GFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCikDKNNAIWSNKAPFCMLKECNDPPSIING--KIYNKR--EMYKVG 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2130696768 376 SRTVYECRP-GFVFVDPNANDTRICDRYGQWSGslDVPQCEPIDCGHP 422
Cdd:PHA02639  107 DEIYYVCNEhKGVQYSLVGNEKITCIQDKSWKP--DPPICKMINCRFP 152
PHA02639 PHA02639
EEV host range protein; Provisional
 59-114 1.52e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.12  E-value: 1.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2130696768  59 CGYPGSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTC---QSNNTWSGRMPIC 114
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFC 80
Sushi pfam00084
Sushi repeat (SCR repeat);
312-345 1.87e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.87  E-value: 1.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2130696768 312 SVEYHCHDGYRLIGQSRRHCdQRTGQWIDKEPYC 345
Cdd:pfam00084  24 SVSYECDPGYRLVGSPTITC-QEDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 298-414 7.17e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 45.75  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130696768 298 GFVLDQQISVDGSRSVEYHCH----DGYRLIGQSRRHCDQrtGQWIDKEPYCERITCPEPvSIMNGFHRMYGEDYYDQPV 373
Cdd:PHA02831   87 GYIKNKKDQYSFGDSVTYACKvnklEKYSIVGNETVKCIN--KQWVPKYPVCKLIRCKYP-ALQNGFLNVFEKKFYYGDI 163

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2130696768 374 VgsrtVYECRPGFVFVdpnANDTRICDRYGQWSGSLdvPQC 414
Cdd:PHA02831  164 V----NFKCKKGFILL---GSSVSTCDINSIWYPGI--PKC 195
PHA02831 PHA02831
EEV host range protein; Provisional
 54-114 1.92e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 41.13  E-value: 1.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2130696768  54 LVRatCGYPgSPRNGRVLHLLERYEEGMVITFECDPGYFLLGPMTRTCQSNNTWSGRMPIC 114
Cdd:PHA02831  138 LIR--CKYP-ALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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