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Conserved domains on  [gi|2127873179|ref|YP_010204202|]
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ribosomal protein L16 (mitochondrion) [Ahnfeltia fastigiata]

Protein Classification

mitochondrial large ribosomal subunit protein uL16m( domain architecture ID 10106530)

mitochondrial large ribosomal subunit protein uL16m

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
 22-111 1.18e-22

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


:

Pssm-ID: 238714  Cd Length: 112  Bit Score: 85.62  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  22 LRFGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngNKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKPG 101
Cdd:cd01433     5 LFFGEYGLVALEPGRITAEQLEAARIAINRYLK-----KKGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPG 79

                          90
                  ....*....|
gi 2127873179 102 FVLFEFSGLS 111
Cdd:cd01433    80 QILFEVRGVP 89
 
Name Accession Description Interval E-value
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
 22-111 1.18e-22

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 85.62  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  22 LRFGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngNKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKPG 101
Cdd:cd01433     5 LFFGEYGLVALEPGRITAEQLEAARIAINRYLK-----KKGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPG 79

                          90
                  ....*....|
gi 2127873179 102 FVLFEFSGLS 111
Cdd:cd01433    80 QILFEVRGVP 89
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
 21-114 1.75e-19

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 77.80  E-value: 1.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  21 FLRFGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKP 100
Cdd:TIGR01164  24 TVAFGEYGLQALEPGWITARQIEAARVAMTRYVK------RGGKLWIRIFPDKPYTKKPLETRMGKGKGNPEYWVAVVKP 97

                          90
                  ....*....|....
gi 2127873179 101 GFVLFEFSGLSRHQ 114
Cdd:TIGR01164  98 GKILFEIAGVPEEV 111
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
12-109 6.99e-16

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 68.99  E-value: 6.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  12 PSKTSYSRHFLR-------------FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKEvsngNKNFKIWSLLSTNLSLTKL 78
Cdd:pfam00252   1 PKRTKYRKSRKRyirgvptkgttldFGDYGLVALEGGQITARQLEAARIAINRYLKK----TRGGKLWIRVFPDKPVTKK 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2127873179  79 SSESRMGKGKGSV-YTHALfVKPGFVLFEFSG 109
Cdd:pfam00252  77 PGEDRMGKGKGKPeGWVAR-VKPGRILFEIKG 107
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 24-111 1.99e-12

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 60.05  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  24 FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSV-YTHAlFVKPGF 102
Cdd:COG0197    29 FGNYGLKALEPGQITSRQIEAARIAITRYLK------RGGKVWIRIFPDKPLTKKPAETRMGAGKGKPeGWVA-VVKPGR 101


                  ....*....
gi 2127873179 103 VLFEFSGLS 111
Cdd:COG0197   102 ILFEIAGVS 110
rpl16 CHL00044
ribosomal protein L16
 24-111 2.23e-09

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 51.82  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  24 FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKPGFV 103
Cdd:CHL00044   29 FGRYALQALEPAWITSRQIEAGRRAITRYAR------RGGKIWIRIFPDKPVTMRPAETRMGSGKGSPEYWVAVVKPGRI 102


                  ....*...
gi 2127873179 104 LFEFSGLS 111
Cdd:CHL00044  103 LYEMGGVS 110
 
Name Accession Description Interval E-value
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
 22-111 1.18e-22

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 85.62  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  22 LRFGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngNKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKPG 101
Cdd:cd01433     5 LFFGEYGLVALEPGRITAEQLEAARIAINRYLK-----KKGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPG 79

                          90
                  ....*....|
gi 2127873179 102 FVLFEFSGLS 111
Cdd:cd01433    80 QILFEVRGVP 89
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
 21-114 1.75e-19

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 77.80  E-value: 1.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  21 FLRFGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKP 100
Cdd:TIGR01164  24 TVAFGEYGLQALEPGWITARQIEAARVAMTRYVK------RGGKLWIRIFPDKPYTKKPLETRMGKGKGNPEYWVAVVKP 97

                          90
                  ....*....|....
gi 2127873179 101 GFVLFEFSGLSRHQ 114
Cdd:TIGR01164  98 GKILFEIAGVPEEV 111
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
12-109 6.99e-16

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 68.99  E-value: 6.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  12 PSKTSYSRHFLR-------------FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKEvsngNKNFKIWSLLSTNLSLTKL 78
Cdd:pfam00252   1 PKRTKYRKSRKRyirgvptkgttldFGDYGLVALEGGQITARQLEAARIAINRYLKK----TRGGKLWIRVFPDKPVTKK 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2127873179  79 SSESRMGKGKGSV-YTHALfVKPGFVLFEFSG 109
Cdd:pfam00252  77 PGEDRMGKGKGKPeGWVAR-VKPGRILFEIKG 107
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 24-111 1.99e-12

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 60.05  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  24 FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSV-YTHAlFVKPGF 102
Cdd:COG0197    29 FGNYGLKALEPGQITSRQIEAARIAITRYLK------RGGKVWIRIFPDKPLTKKPAETRMGAGKGKPeGWVA-VVKPGR 101


                  ....*....
gi 2127873179 103 VLFEFSGLS 111
Cdd:COG0197   102 ILFEIAGVS 110
rpl16 CHL00044
ribosomal protein L16
 24-111 2.23e-09

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 51.82  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127873179  24 FGQFGIKATSSGRLTEEQLNSLDRLLIKKLKevsngnKNFKIWSLLSTNLSLTKLSSESRMGKGKGSVYTHALFVKPGFV 103
Cdd:CHL00044   29 FGRYALQALEPAWITSRQIEAGRRAITRYAR------RGGKIWIRIFPDKPVTMRPAETRMGSGKGSPEYWVAVVKPGRI 102


                  ....*...
gi 2127873179 104 LFEFSGLS 111
Cdd:CHL00044  103 LYEMGGVS 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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