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hypothetical protein LK462_06870 [Burkholderia vietnamiensis]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
DHFR super family | cl17279 | Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with ... |
1-39 | 1.73e-03 | ||
Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase. Inhibition of DHFR interrupts thymidilate synthesis and DNA replication, inhibitors of DHFR (such as Methotrexate) are used in cancer chemotherapy. 5,6,7,8-tetrahydrofolate also is involved in glycine, serine, and threonine metabolism and aminoacyl-tRNA biosynthesis. The actual alignment was detected with superfamily member PRK10786: Pssm-ID: 473077 [Multi-domain] Cd Length: 367 Bit Score: 33.59 E-value: 1.73e-03
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Name | Accession | Description | Interval | E-value | ||
ribD | PRK10786 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6- ... |
1-39 | 1.73e-03 | ||
bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD; Pssm-ID: 182729 [Multi-domain] Cd Length: 367 Bit Score: 33.59 E-value: 1.73e-03
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Name | Accession | Description | Interval | E-value | ||
ribD | PRK10786 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6- ... |
1-39 | 1.73e-03 | ||
bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD; Pssm-ID: 182729 [Multi-domain] Cd Length: 367 Bit Score: 33.59 E-value: 1.73e-03
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Blast search parameters | ||||
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