NCBI Conserved Domain Search

Conserved domains on [gi|2127773551|gb|UEB99765|]

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sensor histidine kinase [Burkholderia vietnamiensis]

Protein Classification

sensor histidine kinase( domain architecture ID 12081975)

sensor histidine kinase with the transmembrane region and the extracellular 2 domain of 7TM-DISM (7TM Receptors with Diverse Intracellular Signaling Modules), part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to external signals

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

339-664

2.78e-54

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 190.50 E-value: 2.78e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 339 ARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIVGLATHLLVLAAWINHVGRQRTEARKRLEHWQLTE 418
Cdd:COG0642     2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 419 QDRLRDEVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPGQARLIRSIDRSIRYQLTLI 498
Cdd:COG0642    82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 499 DELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRpLTPLPRKLTIDGIRLQQVLLNLLSNASKFTR 578
Cdd:COG0642   162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELD-LPDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 579 DGTvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN--GGTGLGLFIAQRIVGAMNGELAVSSQPGV 656
Cdd:COG0642   241 EGG-TVTVSVRREGD--RVRISVEDTGPGIPPEDLERIFEPFFRTDPSRrgGGTGLGLAIVKRIVELHGGTIEVESEPGK 317


                  ....*...
gi 2127773551 657 GTSFTFQI 664
Cdd:COG0642   318 GTTFTVTL 325

7TMR-DISMED2

pfam07696

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...

43-166

1.01e-14

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives. It can also recognize Ca(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 429601 Cd Length: 127 Bit Score: 71.22 E-value: 1.01e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  43 VALLEDPGAALSASEVATRVAERQRraaePARPSFNIEFSRSAWWVGATLVNRAATRQPMVLAIRDARVDRADFYVEHGG 122
Cdd:pfam07696   1 VEYLEDPTGSLTIEDVLSADGRFRP----PEKGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYPLLDEIDLYLPDGG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2127773551 123 ----QWTLAGRFPARDGSLGepvSRYPVLAATLDAGERLPVLVRVTSR 166
Cdd:pfam07696  77 ggyrEQRLGDRLPFSQRPVA---HRNFVFPLPLPPGETVTLYLRVKSS 121

7TMR-DISM_7TM

pfam07695

7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...

190-365

7.08e-11

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).

Pssm-ID: 429600 [Multi-domain] Cd Length: 207 Bit Score: 62.29 E-value: 7.08e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 190 MWNFGFLGGLLALMWCALLIGFFSRSGTFAVLALLALGTALFEATYRGYTALYLWPGA-YEWSARAEMVSVYLSLACF-I 267
Cdd:pfam07695   3 LLLGLFYGILLALALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNApPWLNNKLLYLSLLLLLPFFaL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 268 AFILLIADREKTGMPMRAAYLVFLAFECVGMAGAACGDLLTFTWLSLRVNAALAVMNISLALILAFRRTPTARVMLIAIS 347
Cdd:pfam07695  83 LFARSFLELKKYLPRLLRLLLGLALLLALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKGYKPARYFLLAWL 162

                         170
                  ....*....|....*...
gi 2127773551 348 FAGFNMLIRVLDARGAIP 365
Cdd:pfam07695 163 LLLIGALIDILSLLGLLP 180

Name

Accession

Description

Interval

E-value

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

339-664

2.78e-54

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 190.50 E-value: 2.78e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 339 ARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIVGLATHLLVLAAWINHVGRQRTEARKRLEHWQLTE 418
Cdd:COG0642     2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 419 QDRLRDEVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPGQARLIRSIDRSIRYQLTLI 498
Cdd:COG0642    82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 499 DELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRpLTPLPRKLTIDGIRLQQVLLNLLSNASKFTR 578
Cdd:COG0642   162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELD-LPDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 579 DGTvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN--GGTGLGLFIAQRIVGAMNGELAVSSQPGV 656
Cdd:COG0642   241 EGG-TVTVSVRREGD--RVRISVEDTGPGIPPEDLERIFEPFFRTDPSRrgGGTGLGLAIVKRIVELHGGTIEVESEPGK 317


                  ....*...
gi 2127773551 657 GTSFTFQI 664
Cdd:COG0642   318 GTTFTVTL 325

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

454-694

9.90e-44

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 169.74 E-value: 9.90e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIHGYAKLLLQTA-TPGQARLIRSIDRSiryQLTL------IDELLQYTRAELQplgIAPDATDLPGLLD 526
Cdd:PRK11091  290 ISHELRTPLNGIVGLSRILLDTElTAEQRKYLKTIHVS---AITLgnifndIIDMDKMERRKLQ---LDNQPIDFTDFLA 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 527 DIGDYALALCAQQNNRFDYRPLTPLPRKLTIDGIRLQQVLLNLLSNASKFTRDGTVTLSIGayRQAGAwRLVFEVADTGI 606
Cdd:PRK11091  364 DLENLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVR--YEEGD-MLTFEVEDSGI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 607 GIELDQTTDIFRAYQQVQAVNG-----GTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQIVAPALGHALIPASALAR 681
Cdd:PRK11091  441 GIPEDELDKIFAMYYQVKDSHGgkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVEDAFDEDD 520

                         250
                  ....*....|...
gi 2127773551 682 TVQPAEQIDLLAD 694
Cdd:PRK11091  521 MPLPALNILLVED 533

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

562-664

7.69e-36

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 131.08 E-value: 7.69e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTVTLSI-GAYRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN----GGTGLGLFI 636
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEVTLRVsLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkyGGTGLGLAI 80

                          90       100
                  ....*....|....*....|....*...
gi 2127773551 637 AQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTL 108

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

557-664

5.53e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 108.51 E-value: 5.53e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  557 IDGIRLQQVLLNLLSNASKFT-RDGTVTLSIgayRQAGAWrLVFEVADTGIGIELDQTTDIFRAYQQVQAVN---GGTGL 632
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTL---ERDGDH-VEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2127773551  633 GLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITL 108

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

558-664

2.42e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.21 E-value: 2.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFT---RDGTVTLSIGAyrqagawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN-GGTGLG 633
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAakaGEITVTLSEGG-------ELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2127773551 634 LFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTL 105

7TMR-DISMED2

pfam07696

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...

43-166

1.01e-14

Pssm-ID: 429601 Cd Length: 127 Bit Score: 71.22 E-value: 1.01e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  43 VALLEDPGAALSASEVATRVAERQRraaePARPSFNIEFSRSAWWVGATLVNRAATRQPMVLAIRDARVDRADFYVEHGG 122
Cdd:pfam07696   1 VEYLEDPTGSLTIEDVLSADGRFRP----PEKGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYPLLDEIDLYLPDGG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2127773551 123 ----QWTLAGRFPARDGSLGepvSRYPVLAATLDAGERLPVLVRVTSR 166
Cdd:pfam07696  77 ggyrEQRLGDRLPFSQRPVA---HRNFVFPLPLPPGETVTLYLRVKSS 121

7TMR-DISM_7TM

pfam07695

7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...

190-365

7.08e-11

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).

Pssm-ID: 429600 [Multi-domain] Cd Length: 207 Bit Score: 62.29 E-value: 7.08e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 190 MWNFGFLGGLLALMWCALLIGFFSRSGTFAVLALLALGTALFEATYRGYTALYLWPGA-YEWSARAEMVSVYLSLACF-I 267
Cdd:pfam07695   3 LLLGLFYGILLALALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNApPWLNNKLLYLSLLLLLPFFaL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 268 AFILLIADREKTGMPMRAAYLVFLAFECVGMAGAACGDLLTFTWLSLRVNAALAVMNISLALILAFRRTPTARVMLIAIS 347
Cdd:pfam07695  83 LFARSFLELKKYLPRLLRLLLGLALLLALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKGYKPARYFLLAWL 162

                         170
                  ....*....|....*...
gi 2127773551 348 FAGFNMLIRVLDARGAIP 365
Cdd:pfam07695 163 LLLIGALIDILSLLGLLP 180

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

380-655

2.28e-07

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 53.93 E-value: 2.28e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 380 VIAIVGLATHLLVL-AAWINHVG----RQRTEARKRLEHWQLT---EQDRLRDEVAKRTVALNDALQEVKTHMQQKIETL 451
Cdd:TIGR01386 166 LILIAVLLVLLTALlGWWITRLGleplRRLSAVAARISPESLDqrlDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFS 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 452 GYVSHDLRAPLSTIHGYAKLLL---QTATPGQARLIRSIDRSIRyqLT-LIDELLQYTRAELQPLGIAPDATDLPGLLDD 527
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVALsqpRTGEEYREVLESNLEELER--LSrMVSDMLFLARADNGQLALERVRLDLAAELAK 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 528 IGDYALALCAQQNNRFDYRPLTPLPrkltIDGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRLVfeVADTGIG 607
Cdd:TIGR01386 324 VAEYFEPLAEERGVRIRVEGEGLVR----GDPQMFRRAISNLLSNALRHTPDGG-TITVRIERRSDEVRVS--VSNPGPG 396

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2127773551 608 IELDQTTDIF-RAYQQVQAVNG---GTGLGLFIAQRIVGAMNGELAVSSQPG 655
Cdd:TIGR01386 397 IPPEHLSRLFdRFYRVDPARSNsgeGTGLGLAIVRSIMEAHGGRASAESPDG 448

Name

Accession

Description

Interval

E-value

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

339-664

2.78e-54

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 190.50 E-value: 2.78e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 339 ARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIVGLATHLLVLAAWINHVGRQRTEARKRLEHWQLTE 418
Cdd:COG0642     2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 419 QDRLRDEVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPGQARLIRSIDRSIRYQLTLI 498
Cdd:COG0642    82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 499 DELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRpLTPLPRKLTIDGIRLQQVLLNLLSNASKFTR 578
Cdd:COG0642   162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELD-LPDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 579 DGTvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN--GGTGLGLFIAQRIVGAMNGELAVSSQPGV 656
Cdd:COG0642   241 EGG-TVTVSVRREGD--RVRISVEDTGPGIPPEDLERIFEPFFRTDPSRrgGGTGLGLAIVKRIVELHGGTIEVESEPGK 317


                  ....*...
gi 2127773551 657 GTSFTFQI 664
Cdd:COG0642   318 GTTFTVTL 325

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

432-664

2.23e-52

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 182.03 E-value: 2.23e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 432 ALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTA---TPGQARLIRSIDRSIRYQLTLIDELLQYTRAE 508
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlsPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 509 LQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRPLTPLPRkLTIDGIRLQQVLLNLLSNASKFTRDGTvTLSIGA 588
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPL-VYADPELLEQVLANLLDNAIKYSPPGG-TITISA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2127773551 589 YRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN--GGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG2205   159 RREGD--GVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

306-664

6.97e-48

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 174.74 E-value: 6.97e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 306 LLTFTWLSLRVNAALAVMNISLALILAFRRTPTARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIVG 385
Cdd:COG5002    26 LLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 386 LATHLLVLAAWINHVGRQRTEARKRLEHWQLTEQDRLRDEVakRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTI 465
Cdd:COG5002   106 LLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLL--LLAAVERDITELERLEQMRREFVANVSHELRTPLTSI 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 466 HGYAKLLLQTAT---PGQARLIRSIDRSIRYQLTLIDELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNR 542
Cdd:COG5002   184 RGYLELLLDGAAddpEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIE 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 543 FDYRPLTPLPRkLTIDGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQ 622
Cdd:COG5002   264 LELDLPEDPLL-VLGDPDRLEQVLTNLLDNAIKYTPEGG-TITVSLREEDD--QVRISVRDTGIGIPEEDLPRIFERFYR 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2127773551 623 VQAVN----GGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG5002   340 VDKSRsretGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

454-694

9.90e-44

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 169.74 E-value: 9.90e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIHGYAKLLLQTA-TPGQARLIRSIDRSiryQLTL------IDELLQYTRAELQplgIAPDATDLPGLLD 526
Cdd:PRK11091  290 ISHELRTPLNGIVGLSRILLDTElTAEQRKYLKTIHVS---AITLgnifndIIDMDKMERRKLQ---LDNQPIDFTDFLA 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 527 DIGDYALALCAQQNNRFDYRPLTPLPRKLTIDGIRLQQVLLNLLSNASKFTRDGTVTLSIGayRQAGAwRLVFEVADTGI 606
Cdd:PRK11091  364 DLENLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVR--YEEGD-MLTFEVEDSGI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 607 GIELDQTTDIFRAYQQVQAVNG-----GTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQIVAPALGHALIPASALAR 681
Cdd:PRK11091  441 GIPEDELDKIFAMYYQVKDSHGgkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVEDAFDEDD 520

                         250
                  ....*....|...
gi 2127773551 682 TVQPAEQIDLLAD 694
Cdd:PRK11091  521 MPLPALNILLVED 533

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

155-664

4.33e-42

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 160.72 E-value: 4.33e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 155 ERLPVLVRVTSRKELKLAPSAFTRDAWHAYELRAAMWNFGFLGGLLALMWCALLIGFFSRSGTFAVLALLALGTALFEAT 234
Cdd:COG4251     8 LLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 235 YRGYTALYLWPGAYEWSARAEMVSVYLSLACFIAFILLIADREktgmpMRAAYLVFLAFECVGMAGAACGDLLTFTWLSL 314
Cdd:COG4251    88 ELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLL-----LLALLLLEELALLRLALALLLLLLLLLLLLLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 315 RVNAALAVMNISLALILAFRRTPTARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIVGLATHLLVLA 394
Cdd:COG4251   163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 395 AWINHVGRQRTEARKRLEHWQLTEqdrlrdEVAKRTVALNDALQEvkthmqqkIETLGY-VSHDLRAPLSTIHGYAKLLL 473
Cdd:COG4251   243 LLLLLLILVLELLELRLELEELEE------ELEERTAELERSNEE--------LEQFAYvASHDLREPLRKISGFSQLLE 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 474 QTATPGQ----ARLIRSIDRSIRYQLTLIDELLQYTRAELQPLGIAPdaTDLPGLLDDIGDYALALCAQQNNRFDYrplT 549
Cdd:COG4251   309 EDYGDKLdeegREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEP--VDLNELLEEVLEDLEPRIEERGAEIEV---G 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 550 PLPRkLTIDGIRLQQVLLNLLSNASKFTRDGTV-TLSIGAYRQAGAWRlvFEVADTGIGIELDQTTDIFRAYQQVQAVN- 627
Cdd:COG4251   384 PLPT-VRGDPTLLRQVFQNLISNAIKYSRPGEPpRIEIGAEREGGEWV--FSVRDNGIGIDPEYAEKIFEIFQRLHSRDe 460

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 2127773551 628 -GGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG4251   461 yEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498

PRK15347

two component system sensor kinase;

416-664

2.45e-41

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 163.27 E-value: 2.45e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 416 LTEQ-DRLRDEVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGyAKLLLQTA--TPGQARLIRSIDRSIR 492
Cdd:PRK15347  366 LNEQyDTLENKVAERTQALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLG-ALELLQNTplTAEQMDLADTARQCTL 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 493 YQLTLIDELLQYTRAELQPLGIAPDATDLPGLLDDigdyalALCAQQNNRFDyRPLT-------PLPRKLTIDGIRLQQV 565
Cdd:PRK15347  445 SLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQ------AMLTIQGPAQS-KSLTlrtfvgaHVPLYLHLDSLRLRQI 517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 566 LLNLLSNASKFTRDGTVTLSIGAYRQagawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLGLFIAQRIVGAMN 645
Cdd:PRK15347  518 LVNLLGNAVKFTETGGIRLRVKRHEQ----QLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMG 593

                         250
                  ....*....|....*....
gi 2127773551 646 GELAVSSQPGVGTSFTFQI 664
Cdd:PRK15347  594 GELTLFSTPGVGSCFSLVL 612

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

562-664

7.69e-36

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 131.08 E-value: 7.69e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTVTLSI-GAYRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN----GGTGLGLFI 636
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEVTLRVsLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTtrkyGGTGLGLAI 80

                          90       100
                  ....*....|....*....|....*...
gi 2127773551 637 AQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTL 108

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

305-664

4.51e-29

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 119.52 E-value: 4.51e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 305 DLLTFTWLSLRVNAALAVMNISLALILAFRRTPTARVMLIAISFAGFNMLIRVLDARGAIPGWLPWLRSDIYPNPVIAIV 384
Cdd:COG4191     1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 385 GLATHLLVLAAWINHVGRQRTEARKRLEHWQLTEQDRLRDEVAKRTVALNDALQEvkthmQQKIETLGY----VSHDLRA 460
Cdd:COG4191    81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQ-----SEKLAALGElaagIAHEINN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 461 PLSTIHGYAKLLL----QTATPGQAR-LIRSIDRSIRYQLTLIDELLQYTRAElqplGIAPDATDLPGLLDDIGDYALAL 535
Cdd:COG4191   156 PLAAILGNAELLRrrleDEPDPEELReALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDEALELLRPR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 536 CAQQNNRFDYRPLTPLPRkLTIDGIRLQQVLLNLLSNAS---KFTRDGTVTLSIgayRQAGAWrLVFEVADTGIGIELDQ 612
Cdd:COG4191   232 LKARGIEVELDLPPDLPP-VLGDPGQLEQVLLNLLINAIdamEEGEGGRITIST---RREGDY-VVISVRDNGPGIPPEV 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2127773551 613 TTDIFRAYQQVQAVNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG4191   307 LERIFEPFFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

557-664

5.53e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 108.51 E-value: 5.53e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  557 IDGIRLQQVLLNLLSNASKFT-RDGTVTLSIgayRQAGAWrLVFEVADTGIGIELDQTTDIFRAYQQVQAVN---GGTGL 632
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTpEGGRITVTL---ERDGDH-VEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGL 76

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2127773551  633 GLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:smart00387  77 GLSIVKKLVELHGGEISVESEPGGGTTFTITL 108

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

415-661

1.16e-27

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 115.33 E-value: 1.16e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 415 QLTEQDRLRDEVAKRtvalndalqevkthmqQKIETLGY----VSHDLRAPLSTIHGYAKLLLQTATPGQAR-----LIR 485
Cdd:COG3852   115 DITERKRLERELRRA----------------EKLAAVGElaagLAHEIRNPLTGIRGAAQLLERELPDDELReytqlIIE 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 486 SIDRsIRyqlTLIDELLQYTRaelqPLGIAPDATDLPGLLDDIGDYALALCAQQNN-RFDYRPltPLPrKLTIDGIRLQQ 564
Cdd:COG3852   179 EADR-LN---NLVDRLLSFSR----PRPPEREPVNLHEVLERVLELLRAEAPKNIRiVRDYDP--SLP-EVLGDPDQLIQ 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 565 VLLNLLSNASKFTRD-GTVTLSIGAYRQAGAWR------LVFEVADTGIGIELDQTTDIF------RAyqqvqavnGGTG 631
Cdd:COG3852   248 VLLNLVRNAAEAMPEgGTITIRTRVERQVTLGGlrprlyVRIEVIDNGPGIPEEILDRIFepffttKE--------KGTG 319

                         250       260       270
                  ....*....|....*....|....*....|
gi 2127773551 632 LGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:COG3852   320 LGLAIVQKIVEQHGGTIEVESEPGKGTTFR 349

PRK11107

hybrid sensory histidine kinase BarA; Provisional

447-665

2.27e-27

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 119.18 E-value: 2.27e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 447 KIETLGYVSHDLRAPLSTIHGYAKLLLQTA-TPGQARLIRSIDRSIRYQLTLIDELLQYTRAE-----LQ--PLG----- 513
Cdd:PRK11107  293 KSEFLANMSHELRTPLNGVIGFTRQTLKTPlTPTQRDYLQTIERSANNLLAIINDILDFSKLEagklvLEniPFSlretl 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 514 ------IAPDATDlPGLlddigdyALALCAQQNnrfdyrpltpLPRKLTIDGIRLQQVLLNLLSNASKFTRDGTVTLSIG 587
Cdd:PRK11107  373 devvtlLAHSAHE-KGL-------ELTLNIDPD----------VPDNVIGDPLRLQQIITNLVGNAIKFTESGNIDILVE 434

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 588 AYRQAG-AWRLVFEVADTGIGIELDQTTDIFRAYQQVQAV----NGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTF 662
Cdd:PRK11107  435 LRALSNtKVQLEVQIRDTGIGISERQQSQLFQAFRQADASisrrHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWF 514


                  ...
gi 2127773551 663 QIV 665
Cdd:PRK11107  515 HLP 517

PRK10841

two-component system sensor histidine kinase RcsC;

431-664

1.65e-24

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 110.06 E-value: 1.65e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 431 VALNDALQEVKTHMQQ----KIETLGYVSHDLRAPLSTIHGyaKL-LLQTAT--PGQARLIRSIDRSIRYQLTLIDELLQ 503
Cdd:PRK10841  427 VKMEESLQEMAQAAEQasqsKSMFLATVSHELRTPLYGIIG--NLdLLQTKElpKGVDRLVTAMNNSSSLLLKIISDILD 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 504 YTRAELQPLGIAPDATDLPGLLDDI-GDYaLALCAQqnnrfdyRPLT------P-LPRKLTIDGIRLQQVLLNLLSNASK 575
Cdd:PRK10841  505 FSKIESEQLKIEPREFSPREVINHItANY-LPLVVK-------KRLGlycfiePdVPVALNGDPMRLQQVISNLLSNAIK 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 576 FTRDGTVTLSIgaYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQ----VQAVNGGTGLGLFIAQRIVGAMNGELAVS 651
Cdd:PRK10841  577 FTDTGCIVLHV--RVDGD--YLSFRVRDTGVGIPAKEVVRLFDPFFQvgtgVQRNFQGTGLGLAICEKLINMMDGDISVD 652

                         250
                  ....*....|...
gi 2127773551 652 SQPGVGTSFTFQI 664
Cdd:PRK10841  653 SEPGMGSQFTIRI 665

PRK11466

hybrid sensory histidine kinase TorS; Provisional

404-664

2.03e-24

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 109.61 E-value: 2.03e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 404 RTEARKRLEHWQ-LTEQDRLRD-EVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLL-QTATPGQ 480
Cdd:PRK11466  399 RSNVHALNRHREqLAAQVKARTaELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAdNPALNAQ 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 481 ARLIRSIDRSIRYQLTLIDELLQYTRAELQPLGIApdATDLPGLLDDIGDYALALcaqQNNRFDYRPLT-------PLPR 553
Cdd:PRK11466  479 RDDLRAITDSGESLLTILNDILDYSAIEAGGKNVS--VSDEPFEPRPLLESTLQL---MSGRVKGRPIRlatdiadDLPT 553

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 554 KLTIDGIRLQQVLLNLLSNASKFTRDGTVTLSIGAYRQAgaWRLvfEVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLG 633
Cdd:PRK11466  554 ALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQ--WLV--EVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLG 629

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2127773551 634 LFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:PRK11466  630 LTISSRLAQAMGGELSATSTPEVGSCFCLRL 660

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

558-664

2.42e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.21 E-value: 2.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFT---RDGTVTLSIGAyrqagawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN-GGTGLG 633
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAakaGEITVTLSEGG-------ELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2127773551 634 LFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:pfam02518  75 LSIVRKLVELLGGTITVESEPGGGTTVTLTL 105

PRK11360

two-component system sensor histidine kinase AtoS;

416-662

5.74e-24

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 107.36 E-value: 5.74e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 416 LTEQDRLRDEVAKrtvalndalqevkthmQQKIETLGY----VSHDLRAPLSTIHGYAKLLLQTATPGQAR-----LIRS 486
Cdd:PRK11360  371 LTERKRLQRRVAR----------------QERLAALGElvagVAHEIRNPLTAIRGYVQIWRQQTSDPPSQeylsvVLRE 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 487 IDRSIRyqltLIDELLQYTRaelqPLGIAPDATDLPGLLDDIGDYALALCAQQNNRF--DYRPLTPLprkLTIDGIRLQQ 564
Cdd:PRK11360  435 VDRLNK----VIDQLLEFSR----PRESQWQPVSLNALVEEVLQLFQTAGVQARVDFetELDNELPP---IWADPELLKQ 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 565 VLLNLLSNASK-FTRDGTVTLSIgayRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAvnGGTGLGLFIAQRIVGA 643
Cdd:PRK11360  504 VLLNILINAVQaISARGKIRIRT---WQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINA 578

                         250
                  ....*....|....*....
gi 2127773551 644 MNGELAVSSQPGVGTSFTF 662
Cdd:PRK11360  579 HGGDIEVESEPGVGTTFTL 597

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

445-661

2.13e-22

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 100.81 E-value: 2.13e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 445 QQKIETLGYV----SHDLRAPLSTIHGYA----KLLLQTATPGQARLIRSIDRSIRyQL----TLIDELLQYTR---AEL 509
Cdd:COG5000   195 AERLAAWGELarriAHEIKNPLTPIQLSAerlrRKLADKLEEDREDLERALDTIIR-QVdrlkRIVDEFLDFARlpePQL 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 510 QPLgiapdatDLPGLLDDIGDYALALCAQQNNRFDYRPLTPLPRkLTIDGIRLQQVLLNLLSNASKFTRD-GTVTLSigA 588
Cdd:COG5000   274 EPV-------DLNELLREVLALYEPALKEKDIRLELDLDPDLPE-VLADRDQLEQVLINLLKNAIEAIEEgGEIEVS--T 343

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2127773551 589 YRQAGawRLVFEVADTGIGIELDQTTDIFRAYqqvqaV---NGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:COG5000   344 RREDG--RVRIEVSDNGPGIPEEVLERIFEPF-----FttkPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFT 412

PRK09959

acid-sensing system histidine kinase EvgS;

414-694

1.07e-21

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 101.35 E-value: 1.07e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  414 WQ-LTEQdrlRDEVAKRTVALNDALQEVKThmqqKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPGQARlIRSIdrSIR 492
Cdd:PRK09959   685 WQdITET---RDLIHALEVERNKAINATVA----KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQR-VEAI--SLA 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  493 YQ-----LTLIDELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRPLTPLPRKLTIDGIRLQQVLL 567
Cdd:PRK09959   755 YAtgqslLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLS 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  568 NLLSNASKFTRDGTVTLSIGAYRQAGAWRLV-FEVADTGIGIELDQTTDIFRAYQQVQA--VNGGTGLGLFIAQRIVGAM 644
Cdd:PRK09959   835 NLLSNALKFTTEGAVKITTSLGHIDDNHAVIkMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNM 914

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2127773551  645 NGELAVSSQPGVGTSFTFQIVAPALGH-ALIPASALARTVQPAEQIDLLAD 694
Cdd:PRK09959   915 QGDLSLESHPGIGTTFTITIPVEISQQvATVEAKAEQPITLPEKLSILIAD 965

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

3.40e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 88.92 E-value: 3.40e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTV-TLSIGAYRQAGAWRlvFEVADTGIGIELDQTTDIFRAYQQVQAVN--GGTGLGLFIAQ 638
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPpRIEVGAEDVGEEWT--FYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVR 78

                          90       100
                  ....*....|....*....|....*.
gi 2127773551 639 RIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16921    79 KIIERHGGRIWLESEPGEGTTFYFTL 104

PRK09303

histidine kinase;

421-662

3.93e-21

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 96.17 E-value: 3.93e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 421 RLRDEvakrtvalNDALQEvKTHMQQKIetLGYVSHDLRAPLSTihgyAKLLLQTATPGQ--------ARLIRSIDRSIR 492
Cdd:PRK09303  136 VLRQE--------NETLLE-QLKFKDRV--LAMLAHDLRTPLTA----ASLALETLELGQidedtelkPALIEQLQDQAR 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 493 YQL----TLIDELLQYTRAELQPLGIAPDATDLPGLLDDIgdyalalCAQQNNRFDYRPL---TPLPRKLTI---DGIRL 562
Cdd:PRK09303  201 RQLeeieRLITDLLEVGRTRWEALRFNPQKLDLGSLCQEV-------ILELEKRWLAKSLeiqTDIPSDLPSvyaDQERI 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 563 QQVLLNLLSNASKFTRD-GTVTLSIgAYR--QagawRLVFEVADTGIGIELDQTTDIF-------RAYQQvqavnGGTGL 632
Cdd:PRK09303  274 RQVLLNLLDNAIKYTPEgGTITLSM-LHRttQ----KVQVSICDTGPGIPEEEQERIFedrvrlpRDEGT-----EGYGI 343

                         250       260       270
                  ....*....|....*....|....*....|
gi 2127773551 633 GLFIAQRIVGAMNGELAVSSQPGVGTSFTF 662
Cdd:PRK09303  344 GLSVCRRIVRVHYGQIWVDSEPGQGSCFHF 373

PRK10364

two-component system sensor histidine kinase ZraS;

445-661

2.30e-20

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 94.85 E-value: 2.30e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 445 QQKIETLGY----VSHDLRAPLSTIHGYAKLLLQTATPG-QAR-----LIRSIDRSIRyqltLIDELLQYTRaelqPLGI 514
Cdd:PRK10364  231 KEKLVALGHlaagVAHEIRNPLSSIKGLAKYFAERAPAGgEAHqlaqvMAKEADRLNR----VVSELLELVK----PTHL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 515 APDATDLpgllDDIGDYALALCAQQNNR----FDYRPLTPLPRkLTIDGIRLQQVLLNLLSNA-SKFTRDGTVTLSIgay 589
Cdd:PRK10364  303 ALQAVDL----NDLINHSLQLVSQDANSreiqLRFTANDTLPE-IQADPDRLTQVLLNLYLNAiQAIGQHGVISVTA--- 374

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2127773551 590 rQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAvnGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:PRK10364  375 -SESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA--EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFT 443

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-667

1.09e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 84.78 E-value: 1.09e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASK-FTRDGTVTLSIGAYRQagawRLVFEVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLGLFIAQRI 640
Cdd:cd16943     4 LNQVLLNLLVNAAQaMEGRGRITIRTWAHVD----QVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*..
gi 2127773551 641 VGAMNGELAVSSQPGVGTsfTFQIVAP 667
Cdd:cd16943    80 IQKHGGTIRVASVPGGGT--RFTIILP 104

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

400-664

8.06e-18

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 87.34 E-value: 8.06e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 400 VGRQRTEaRKRLEHwQLTEQDRLrdevakrtvalndalqevkthmqQKI-ETLGYVSHDLRAPLSTIHGYAKLLLQTATP 478
Cdd:COG5809   247 IFRDITE-RKKLEE-LLRKSEKL-----------------------SVVgELAAGIAHEIRNPLTSLKGFIQLLKDTIDE 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 479 GQARLIRSIDRSIRYQLTLIDELL--------QYTRAELQPLgiapdatdlpgllddIGDYALALCAQ---QNNRFDYRP 547
Cdd:COG5809   302 EQKTYLDIMLSELDRIESIISEFLvlakpqaiKYEPKDLNTL---------------IEEVIPLLQPQallKNVQIELEL 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 548 LTPLPrKLTIDGIRLQQVLLNLLSNASKFT-RDGTVTLSIGAYRQAGawrLVFEVADTGIGIELDQTTDIF-----RAYQ 621
Cdd:COG5809   367 EDDIP-DILGDENQLKQVFINLLKNAIEAMpEGGNITIETKAEDDDK---VVISVTDEGCGIPEERLKKLGepfytTKEK 442

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2127773551 622 qvqavngGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG5809   443 -------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

447-664

3.42e-17

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 84.53 E-value: 3.42e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 447 KIETLGY----VSHDLRAPLSTIHGYAKLLLQTATPGQAR------LIRSIDRSIRyqltLIDELLQYTRAELQPLGIAP 516
Cdd:COG5806   197 KLEVVSElaasIAHEVRNPLTVVRGFIQLLQEPELSDEKRkqyiriALEELDRAEA----IITDYLTFAKPQPEKLEKID 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 517 DATDLPGLLDDIGDYAlalcaqqnNRFDYRPLTPLPRKLTIDGIR--LQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGa 594
Cdd:COG5806   273 VSEELEHVIDVLSPYA--------NMNNVEIQTELEPGLYIEGDRqkLQQCLINIIKNGIEAMPNGG-TLTIDVSIDKN- 342

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 595 wRLVFEVADTGIGIELDQTTDIFRAYQQVQAVngGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG5806   343 -KVIISIKDTGVGMTKEQLERLGEPYFSTKEK--GTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

442-664

5.35e-15

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 77.58 E-value: 5.35e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 442 THMQQKIETLGYVSHDLRAPLSTIHGYAKLLlqtatpgqarlirSIDRSIRYqltlIDELLQYTRAELQPLGIAPDATDL 521
Cdd:COG3290   184 EGVKELAEALRAQRHDFRNHLHTISGLLQLG-------------EYDEALEY----IDEISEELQELIDSLLSRIGNPVL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 522 PGLLddIGDYALAlcAQQNNRFDYRPLTPLPrKLTIDGIRLQQVLLNLLSNA-----SKFTRDGTVTLSIGAYRQagawR 596
Cdd:COG3290   247 AALL--LGKAARA--RERGIDLTIDIDSDLP-DLPLSDTDLVTILGNLLDNAieaveKLPEEERRVELSIRDDGD----E 317

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2127773551 597 LVFEVADTGIGIELDQTTDIFRAYQQVQAvNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG3290   318 LVIEVEDSGPGIPEELLEKIFERGFSTKL-GEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384

PRK11100

sensory histidine kinase CreC; Provisional

380-657

8.53e-15

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 77.58 E-value: 8.53e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 380 VIAIVGLAthllvLAAWIN-HVGRQRTEARKrlehwqLTEQDRL------RDEVAKrtvaLNDALQEVKTHMQQK--IEt 450
Cdd:PRK11100  194 IALLIGAG-----VVWWLNrSIRRLTRYADA------VTEGKPVplpklgSSELRE----LAQALESMRVKLEGKayVE- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 451 lGYV---SHDLRAPLSTIHGYAKLLlQTATPGQ--ARLIRSIDR-SIRYQlTLIDELLQYTRAElQPLGI-APDATDLPG 523
Cdd:PRK11100  258 -QYVqtlTHELKSPLAAIRGAAELL-QEDPPPEdrARFTGNILTqSARLQ-QLIDRLLELARLE-QRQELeVLEPVALAA 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 524 LLDDIGDYALALCAQQNNRFDYRPLtplPRKLTIDGIRLQQVLLNLLSNASKFT-RDGTVTLSIGayRQAGAWRLVfeVA 602
Cdd:PRK11100  334 LLEELVEAREAQAAAKGITLRLRPD---DARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAE--VDGEQVALS--VE 406

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 603 DTGIGI---ELDQTTDIFraYQQVQAVNG--GTGLGLFIAQRIVGAMNGELAVSSQPGVG 657
Cdd:PRK11100  407 DQGPGIpdyALPRIFERF--YSLPRPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEGG 464

7TMR-DISMED2

pfam07696

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...

43-166

1.01e-14

Pssm-ID: 429601 Cd Length: 127 Bit Score: 71.22 E-value: 1.01e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551  43 VALLEDPGAALSASEVATRVAERQRraaePARPSFNIEFSRSAWWVGATLVNRAATRQPMVLAIRDARVDRADFYVEHGG 122
Cdd:pfam07696   1 VEYLEDPTGSLTIEDVLSADGRFRP----PEKGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYPLLDEIDLYLPDGG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2127773551 123 ----QWTLAGRFPARDGSLGepvSRYPVLAATLDAGERLPVLVRVTSR 166
Cdd:pfam07696  77 ggyrEQRLGDRLPFSQRPVA---HRNFVFPLPLPPGETVTLYLRVKSS 121

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

558-664

2.65e-14

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 69.44 E-value: 2.65e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFTRDG---TVTLSIGayrqaGAWRLVFEVADTGIGIELDQTTDIFRAYQQV----QAVNGGT 630
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGgriRCILEKF-----RLNRFLLTVSDSGPGIPPNLREEIFERFRQGdgssTRAHGGT 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2127773551 631 GLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16925    76 GLGLSIVKEFVELHGGTVTVSDAPGGGALFQVEL 109

PRK10604

sensor protein RstB; Provisional

454-662

6.57e-14

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 74.64 E-value: 6.57e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIHGYAKLLLQTATPGQARLIRSIDrsiryQL-TLIDELLQYTRAELQPLGIAPDATDLPGLLDDIGDYA 532
Cdd:PRK10604  219 IAHELRTPLVRLRYRLEMSDNLSAAESQALNRDIG-----QLeALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 533 LALCAQQNNRFDyRPLTPLPrkLTIDGIRLQQVLLNLLSNASKFTRDgtvTLSIGAYRQAGAWRLvfEVADTGIGIELDQ 612
Cdd:PRK10604  294 QAVTPEKTVRLD-TPHQGDY--GALDMRLMERVLDNLLNNALRYAHS---RVRVSLLLDGNQACL--IVEDDGPGIPPEE 365

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2127773551 613 TTDIFRAYQQVQA----VNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTF 662
Cdd:PRK10604  366 RERVFEPFVRLDPsrdrATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSF 419

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

454-664

1.07e-13

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 73.89 E-value: 1.07e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIHGYAKLLLQTATPGQAR--LIRSIDRSIRYQLTLIDELLQYTRAELQPLGIAPDATDLPGLLDDIGDY 531
Cdd:PRK11006  211 VSHELRTPLTVLQGYLEMMQDQPLEGALRekALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLERE 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 532 ALALCAQQNN-RFDYRPltplprKLTIDGI--RLQQVLLNLLSNASKFTRDGTvTLSIGAYRQA-GAWrlvFEVADTGIG 607
Cdd:PRK11006  291 AQTLSQGKHTiTFEVDN------SLKVFGNedQLRSAISNLVYNAVNHTPEGT-HITVRWQRVPqGAE---FSVEDNGPG 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2127773551 608 IE---LDQTTDIF------RAYQqvqavNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:PRK11006  361 IApehIPRLTERFyrvdkaRSRQ-----TGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

1.41e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 67.42 E-value: 1.41e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTVT---LSIGaYRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAvnGGTGLGLFIAQ 638
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGCErreLTIR-TSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICR 77

                          90       100
                  ....*....|....*....|....*.
gi 2127773551 639 RIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16920    78 SIIEAHGGRLSVESPAGGGATFQFTL 103

PRK10755

two-component system sensor histidine kinase PmrB;

424-648

4.64e-13

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 71.15 E-value: 4.64e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 424 DEVAKRTVALNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPGQARLIRSIDRSIRyqltLIDELLQ 503
Cdd:PRK10755  114 LEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVAPLIARLDQMMH----TVEQLLQ 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 504 YTRAE-------LQPLGiapdatdlpgLLDDI----GDYALALCAQQNNRFDYrPLTPLPRKLTIDGIRLQQVLLNLLSN 572
Cdd:PRK10755  190 LARAGqsfssghYQTVK----------LLEDVilpsQDELSEMLEQRQQTLLL-PESAADITVQGDATLLRLLLRNLVEN 258

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2127773551 573 ASKFTRDGTvTLSIGAYRQAGAWRLvfEVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLGLFIAQRIVGAMNGEL 648
Cdd:PRK10755  259 AHRYSPEGS-TITIKLSQEDGGAVL--AVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQF 331

PRK13837

two-component system VirA-like sensor kinase;

391-660

8.85e-13

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 72.02 E-value: 8.85e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 391 LVLAAWINHVGRQRTEA-RKRLEHwqlteqdrlRDEVAKRtvalndaLQEVKThmqqkieTLGYVSHDLRAPLSTIHGYA 469
Cdd:PRK13837  416 LALDCLAHAIERRRLETeRDALER---------RLEHARR-------LEAVGT-------LASGIAHNFNNILGAILGYA 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 470 KLLLQTATPGQ--ARLIRSIDRSIRYQLTLIDELLQYTRAelQPLGIAPdaTDLPGLLDDIGDyALALCAQQNNRFDYRp 547
Cdd:PRK13837  473 EMALNKLARHSraARYIDEIISAGARARLIIDQILAFGRK--GERNTKP--FDLSELVTEIAP-LLRVSLPPGVELDFD- 546

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 548 LTPLPRKLTIDGIRLQQVLLNLLSNASK-FTRDGTVTLSIGAYRQAGAWRL-----------VFEVADTGIGIELDQTTD 615
Cdd:PRK13837  547 QDQEPAVVEGNPAELQQVLMNLCSNAAQaMDGAGRVDISLSRAKLRAPKVLshgvlppgryvLLRVSDTGAGIDEAVLPH 626

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2127773551 616 IFRAYQQVQAvnGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSF 660
Cdd:PRK13837  627 IFEPFFTTRA--GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRF 669

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

2.00e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 64.02 E-value: 2.00e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTV-TLSIGAYRQAGAWRLVfeVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLGLFIAQRI 640
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENpRIRIAARRLGGRLVLV--VRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGI 78

                          90       100
                  ....*....|....*....|....
gi 2127773551 641 VGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16976    79 VEEHGGRLSVANEEGAGARFTFDL 102

PRK10490

sensor protein KdpD; Provisional

451-662

4.46e-12

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 69.68 E-value: 4.46e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 451 LGYVSHDLRAPLSTIHGYAKLL-LQTATPG-----QARLIRS-IDRSIRyqltLIDELLQYTRaeLQPLGIAPDATDLPg 523
Cdd:PRK10490  668 LAALSHDLRTPLTVLFGQAEILtLDLASEGspharQASEIRQqVLNTTR----LVNNLLDMAR--IQSGGFNLRKEWLT- 740

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 524 lLDDIGDYALalcAQQNNRFDYRPLT-PLPRKLTI---DGIRLQQVLLNLLSNASKFTRDGTvTLSIGAyrQAGAWRLVF 599
Cdd:PRK10490  741 -LEEVVGSAL---QMLEPGLSGHPINlSLPEPLTLihvDGPLFERVLINLLENAVKYAGAQA-EIGIDA--HVEGERLQL 813

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2127773551 600 EVADTGIGIELDQTTDIFRAYQQVQAVNG--GTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTF 662
Cdd:PRK10490  814 DVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-661

6.08e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.30 E-value: 6.08e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTVtlsIGAYRQAGAWRLVFEVADTGIGIELDQTTDIF-RAYQQVQAVNG---GTGLGLFIA 637
Cdd:cd16947    21 LQRILKNLISNAIKYGSDGKF---LGMTLREDEKHVYIDIWDKGKGISETEKDHVFeRLYTLEDSRNSakqGNGLGLTIT 97

                          90       100
                  ....*....|....*....|....
gi 2127773551 638 QRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:cd16947    98 KRLAESMGGSIYVNSKPYEKTVFT 121

PRK10549

two-component system sensor histidine kinase BaeS;

383-661

9.40e-12

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 68.12 E-value: 9.40e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 383 IVGLATHLLVLAAWInhVGRQRTEARKRL---EHwQLTEQD-------RLRDEVAKRTVALNDALQEVKTHMQQKIETLG 452
Cdd:PRK10549  169 IVALSTLLAALATFL--LARGLLAPVKRLvegTH-KLAAGDfttrvtpTSRDELGRLAQDFNQLASTLEKNEQMRRDFMA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 453 YVSHDLRAPLSTIHGYAKLL---LQTATPGQarlIRSIDRSIRYQLTLIDELLQYTRAELQPLGIAPDATDLPGLLD-DI 528
Cdd:PRK10549  246 DISHELRTPLAVLRGELEAIqdgVRKFTPES---VASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEvAG 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 529 GDYalalcaqqNNRFDYRPLT---PLPRKLTI--DGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRLVFEvaD 603
Cdd:PRK10549  323 GAF--------RERFASRGLTlqlSLPDSATVfgDPDRLMQLFNNLLENSLRYTDSGG-SLHISAEQRDKTLRLTFA--D 391

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2127773551 604 TGIGIELDQTTDIF-RAYQQVQAVN---GGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:PRK10549  392 SAPGVSDEQLQKLFeRFYRTEGSRNrasGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSIT 453

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

558-662

2.20e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 61.32 E-value: 2.20e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRLVFEvaDTGIGIELDQTTDIFRAYQQVQA----VNGGTGLG 633
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGG-KLRIRAAQTPQEVRLDVE--DSAPGVSDDQLARLFERFYRVESsrnrASGGSGLG 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2127773551 634 LFIAQRIVGAMNGELAVSSQP--GVGTSFTF 662
Cdd:cd16946    78 LAICHNIALAHGGTISAEHSPlgGLRLVLTL 108

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

446-508

3.04e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.50 E-value: 3.04e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2127773551  446 QKIETLGYVSHDLRAPLSTIHGYAKLLLQT-ATPGQARLIRSIDRSIRYQLTLIDELLQYTRAE 508
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTeLSEEQREYLETILREAERLLRLINDLLDLSRIE 64

envZ

PRK09467

osmolarity sensor protein; Provisional

454-654

4.96e-11

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 65.70 E-value: 4.96e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIhgyaKLLLQTATPGQARLIRSIDRSIRYQLTLIDELLQYTR--AELQplgiaPDATDLPGLLDDIgdy 531
Cdd:PRK09467  236 VSHDLRTPLTRI----RLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRtgQEMP-----MEMADLNALLGEV--- 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 532 alalCAQQNNR-----FDyrpLTPLPRKLTIDGIRLQQVLLNLLSNASKFTRdGTVTLSIGAYRQagawRLVFEVADTGI 606
Cdd:PRK09467  304 ----IAAESGYereieTA---LQPGPIEVPMNPIAIKRALANLVVNAARYGN-GWIKVSSGTEGK----RAWFQVEDDGP 371

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2127773551 607 GIELDQTTDIFRAYQQVQAVNG--GTGLGLFIAQRIVGAMNGELAVSSQP 654
Cdd:PRK09467  372 GIPPEQLKHLFQPFTRGDSARGssGTGLGLAIVKRIVDQHNGKVELGNSE 421

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-655

5.51e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.11 E-value: 5.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFT--RDGTVTLS--------IGAYRQAGAWRLvfEVADTGIGIELDQTTDIFraYQQVQAVNGGTG 631
Cdd:cd16918     1 LIQVFLNLVRNAAQALagSGGEIILRtrtqrqvtLGHPRHRLALRV--SVIDNGPGIPPDLQDTIF--YPMVSGRENGTG 76

                          90       100
                  ....*....|....*....|....
gi 2127773551 632 LGLFIAQRIVGAMNGELAVSSQPG 655
Cdd:cd16918    77 LGLAIAQNIVSQHGGVIECDSQPG 100

7TMR-DISM_7TM

pfam07695

7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...

190-365

7.08e-11

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).

Pssm-ID: 429600 [Multi-domain] Cd Length: 207 Bit Score: 62.29 E-value: 7.08e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 190 MWNFGFLGGLLALMWCALLIGFFSRSGTFAVLALLALGTALFEATYRGYTALYLWPGA-YEWSARAEMVSVYLSLACF-I 267
Cdd:pfam07695   3 LLLGLFYGILLALALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNApPWLNNKLLYLSLLLLLPFFaL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 268 AFILLIADREKTGMPMRAAYLVFLAFECVGMAGAACGDLLTFTWLSLRVNAALAVMNISLALILAFRRTPTARVMLIAIS 347
Cdd:pfam07695  83 LFARSFLELKKYLPRLLRLLLGLALLLALLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIAWRKGYKPARYFLLAWL 162

                         170
                  ....*....|....*...
gi 2127773551 348 FAGFNMLIRVLDARGAIP 365
Cdd:pfam07695 163 LLLIGALIDILSLLGLLP 180

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

444-506

1.08e-10

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.61 E-value: 1.08e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2127773551 444 MQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTA--TPGQARLIRSIDRSIRYQLTLIDELLQYTR 506
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELldDEEQREYLERIREEAERLLRLINDLLDLSR 65

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

446-508

1.15e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.61 E-value: 1.15e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2127773551 446 QKIETLGYVSHDLRAPLSTIHGYAKLLLQT-ATPGQARLIRSIDRSIRYQLTLIDELLQYTRAE 508
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEkLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-657

1.29e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 58.61 E-value: 1.29e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRdgtvtLSIGAYRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAVNG--GTGLGLFIAQR 639
Cdd:cd16950     1 LKRVLSNLVDNALRYGG-----GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGtsGTGLGLAIVQR 75

                          90
                  ....*....|....*...
gi 2127773551 640 IVGAMNGELAVSSQPGVG 657
Cdd:cd16950    76 ISDAHGGSLTLANRAGGG 93

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

1.41e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 58.75 E-value: 1.41e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRlvFEVADTGIGIE---LDQTTDIFRAYQQVQAVN-GGTGLGLFIA 637
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSD-TITVRWSQEESGAR--LSVEDTGPGIPpehIPRLTERFYRVDIERCRNtGGTGLGLAIV 77

                          90       100
                  ....*....|....*....|....*..
gi 2127773551 638 QRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16952    78 KHVMSRHDARLLIASELGKGSRFTCLF 104

glnL

PRK11073

nitrogen regulation protein NR(II);

544-661

3.16e-10

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 62.41 E-value: 3.16e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 544 DYRPLTPlprKLTIDGIRLQQVLLNLLSNASKF--TRDGTVTLSIGAYRQAGA----WRLV--FEVADTGIGI--ELDQT 613
Cdd:PRK11073  223 DYDPSLP---ELAHDPDQIEQVLLNIVRNALQAlgPEGGTITLRTRTAFQLTLhgerYRLAarIDIEDNGPGIppHLQDT 299

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2127773551 614 tdIFraYQQVQAVNGGTGLGLFIAQRIVGAMNGELAVSSQPGvGTSFT 661
Cdd:PRK11073  300 --LF--YPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFS 342

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

5.21e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 57.34 E-value: 5.21e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDgtvTLSIGAYRQAGAWrlVFEVADTGIGIELDQTTDIFRAYQQV----QAVNGGTGLGLFIA 637
Cdd:cd16949     1 LARALENVLRNALRYSPS---KILLDISQDGDQW--TITITDDGPGVPEDQLEQIFLPFYRVdsarDRESGGTGLGLAIA 75

                          90       100
                  ....*....|....*....|....*..
gi 2127773551 638 QRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16949    76 ERAIEQHGGKIKASNRKPGGLRVRIWL 102

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

402-652

5.50e-10

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.78 E-value: 5.50e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 402 RQRTEARKRLEHWQLTEQDRLRDEvakrtvalndalqevkTHMQQKIETLGYVSHDLRAPLSTIHGY---AKLLLQTATP 478
Cdd:COG4192   404 ETEIEERKRIEKNLRQTQDELIQA----------------AKMAVVGQTMTSLAHELNQPLNAMSMYlfsAKKALEQENY 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 479 GQAR-LIRSIDRSIRYQLTLIDELLQYTRAELQPLGiapdATDLPGLLDDigdyALALCAQQNNRFDYRPLTPLPRKLTI 557
Cdd:COG4192   468 AQLPtSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQ----PVDLRQVIEQ----AWELVESRAKPQQITLHIPDDLMVQG 539

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASkftrDGTVT---LSIGAYRQAGAWRLVfeVADTGIGIEL-DQTTDIFRAYQQVqavngGTGLG 633
Cdd:COG4192   540 DQVLLEQVLVNLLVNAL----DAVATqpqISVDLLSNAENLRVA--ISDNGNGWPLvDKLFTPFTTTKEV-----GLGLG 608

                         250
                  ....*....|....*....
gi 2127773551 634 LFIAQRIVGAMNGELAVSS 652
Cdd:COG4192   609 LSICRSIMQQFGGDLYLAS 627

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

416-669

1.27e-09

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 61.87 E-value: 1.27e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 416 LTEQDRlrdE--VAKRtvaLNDALQEVKTHMQQKIETLGYVSHDLRAPLSTIHGYAKLLLQTATPG-QARLIRSIDRSIR 492
Cdd:PRK10618  423 LRDQDR---EvlVNKK---LQQAQREYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEqQQPELDQLAEQSD 496

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 493 YQLTLIDELLQYTRAELQPLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYRPLTPLPRKLTIDGIRLQQVLLNLLSN 572
Cdd:PRK10618  497 VLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKILLLLLNY 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 573 ASKFTRDGTVTLSIgAYRQAGAWRLVFEVADTGIGIELDQTTDI---FRAYQQVQAVNGGTGLGLFIAQRIVGAMNGELA 649
Cdd:PRK10618  577 AITTTAYGKITLEV-DQDESSPDRLTIRILDTGAGVSIKELDNLhfpFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLT 655

                         250       260
                  ....*....|....*....|
gi 2127773551 650 VSSQPGVGTSFTFQIVAPAL 669
Cdd:PRK10618  656 IKSREGLGTRYSIHLKMLAA 675

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

552-658

2.56e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 55.49 E-value: 2.56e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 552 PRKLTIDGIRLQQVLLNLLSNASKFTRDGTVtLSIgayRQAGAWRLVFEVADTGIGIELDQTTDIFRAYQQVQAVN-GGT 630
Cdd:cd16940     4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSR-VEI---KLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNyGGS 79

                          90       100
                  ....*....|....*....|....*...
gi 2127773551 631 GLGLFIAQRIVGAMNGELAVSSQPGVGT 658
Cdd:cd16940    80 GLGLSIVKRIVELHGGQIFLGNAQGGGL 107

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

562-660

3.41e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 55.08 E-value: 3.41e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNAskftRD-----GTVTLSI----------GAYRQAGAWRLV-FEVADTGIGIELDQTTDIFRAYQQVQA 625
Cdd:cd16919     1 LELAILNLAVNA----RDampegGRLTIETsnqrvdadyaLNYRDLIPGNYVcLEVSDTGSGMPAEVLRRAFEPFFTTKE 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2127773551 626 VNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSF 660
Cdd:cd16919    77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTV 111

PRK11086

sensory histidine kinase DcuS; Provisional

565-664

5.68e-09

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.54 E-value: 5.68e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 565 VLLNLLSN---ASKFTRDGTVTLSIgaYRQAGawRLVFEVADTGIGIELDQTTDIFRayQQVQAVNGGTGLGLFIAQRIV 641
Cdd:PRK11086  437 ILGNLIENaleAVGGEEGGEISVSL--HYRNG--WLHCEVSDDGPGIAPDEIDAIFD--KGYSTKGSNRGVGLYLVKQSV 510

                          90       100
                  ....*....|....*....|...
gi 2127773551 642 GAMNGELAVSSQPGVGTSFTFQI 664
Cdd:PRK11086  511 ENLGGSIAVESEPGVGTQFFVQI 533

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

454-661

3.30e-08

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 56.66 E-value: 3.30e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 454 VSHDLRAPLSTIHGYAKLLLQTATPGQ--ARLIRS-IDR---------------SIRYQLTLIDELLQYTRAELQPlgia 515
Cdd:COG5805   294 IAHEIRNPLTSIKGFLQLLQPGIEDKEeyFDIMLSeLDRiesiiseflalakpqAVNKEKENINELIQDVVTLLET---- 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 516 pDATdlpglLDDIgdyalalcaqqNNRFDYrpLTPLPrKLTIDGIRLQQVLLNLLSNASKFTRD-GTVTLSIGAYRQAga 594
Cdd:COG5805   370 -EAI-----LHNI-----------QIRLEL--LDEDP-FIYCDENQIKQVFINLIKNAIEAMPNgGTITIHTEEEDNS-- 427

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 595 wrLVFEVADTGIGIE---LDQTTDIFRAYQQvqavnGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:COG5805   428 --VIIRVIDEGIGIPeerLKKLGEPFFTTKE-----KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFT 490

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

558-664

1.08e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 50.54 E-value: 1.08e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAwrLVFEVADTGIGI---ELDQTTDIFRAYQQVQAVNGGTGLGL 634
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGG-TVSISIYDEEEY--LYFEIWDNGHGFseqDLKKALELFYRDDTSRRSGGHYGMGL 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 2127773551 635 FIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16975    78 YIAKNLVEKHGGSLIIENSQKGGAEVTVKI 107

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

380-655

2.28e-07

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 53.93 E-value: 2.28e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 380 VIAIVGLATHLLVL-AAWINHVG----RQRTEARKRLEHWQLT---EQDRLRDEVAKRTVALNDALQEVKTHMQQKIETL 451
Cdd:TIGR01386 166 LILIAVLLVLLTALlGWWITRLGleplRRLSAVAARISPESLDqrlDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFS 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 452 GYVSHDLRAPLSTIHGYAKLLL---QTATPGQARLIRSIDRSIRyqLT-LIDELLQYTRAELQPLGIAPDATDLPGLLDD 527
Cdd:TIGR01386 246 ADLAHELRTPLTNLLGQTQVALsqpRTGEEYREVLESNLEELER--LSrMVSDMLFLARADNGQLALERVRLDLAAELAK 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 528 IGDYALALCAQQNNRFDYRPLTPLPrkltIDGIRLQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRLVfeVADTGIG 607
Cdd:TIGR01386 324 VAEYFEPLAEERGVRIRVEGEGLVR----GDPQMFRRAISNLLSNALRHTPDGG-TITVRIERRSDEVRVS--VSNPGPG 396

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2127773551 608 IELDQTTDIF-RAYQQVQAVNG---GTGLGLFIAQRIVGAMNGELAVSSQPG 655
Cdd:TIGR01386 397 IPPEHLSRLFdRFYRVDPARSNsgeGTGLGLAIVRSIMEAHGGRASAESPDG 448

HATPase_ETR2_ERS2-EIN4-like

cd16938

Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ...

551-661

7.57e-07

Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 48.99 E-value: 7.57e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 551 LPRKLTIDGIRLQQVLLNLLSNASKFTR-DGTVTLSI--------GAYRQAGAWR---------LVFEVADTGIGIELDQ 612
Cdd:cd16938     1 LPDVVVGDERRVFQVLLHMLGNLLKMRNgGGNITFRVfleggsedRSDRDWGPWRpsmsdesveIRFEVEINDSGSPSIE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2127773551 613 TTDIfRAYQ--QVQAVNGGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFT 661
Cdd:cd16938    81 SASM-RNSLnrRYNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMS 130

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-662

8.06e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 48.20 E-value: 8.06e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDgtvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQV----QAVNGGTGLGLFIA 637
Cdd:cd16939     1 MARALDNLLRNALRYAHR---TVRIALLVSGG--RLTLIVEDDGPGIPAAARERVFEPFVRLdpsrDRATGGFGLGLAIV 75

                          90       100
                  ....*....|....*....|....*
gi 2127773551 638 QRIVGAMNGELAVSSQPGVGTSFTF 662
Cdd:cd16939    76 HRVALWHGGHVECDDSELGGACFRL 100

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

568-664

8.72e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 48.05 E-value: 8.72e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 568 NLLSNA-----SKFTRDGTVTLSIgayRQAGAWrLVFEVADTGIGIELDQTTDIFRAYQQVQAvNGGTGLGLFIAQRIVG 642
Cdd:cd16915     7 NLIDNAldalaATGAPNKQVEVFL---RDEGDD-LVIEVRDTGPGIAPELRDKVFERGVSTKG-QGERGIGLALVRQSVE 81

                          90       100
                  ....*....|....*....|..
gi 2127773551 643 AMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16915    82 RLGGSITVESEPGGGTTFSIRI 103

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

565-663

1.85e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 47.28 E-value: 1.85e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 565 VLLNLLSNASKFTRDGTvTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYqqVQAVNG-----GTGLGLFIAQR 639
Cdd:cd16948     9 IIGQIVSNALKYSKQGG-KIEIYSETNEQ--GVVLSIKDFGIGIPEEDLPRVFDKG--FTGENGrnfqeSTGMGLYLVKK 83

                          90       100
                  ....*....|....*....|....
gi 2127773551 640 IVGAMNGELAVSSQPGVGTSFTFQ 663
Cdd:cd16948    84 LCDKLGHKIDVESEVGEGTTFTIT 107

HATPase_Phy-like

cd16932

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ...

558-648

4.63e-06

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.

Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 46.11 E-value: 4.63e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFT--RDGTVTLSIGAYRQA-----GAWRLVFEVADTGIGIELDQTTDIFRAyqqvqavNGGT 630
Cdd:cd16932     3 DQIRLQQVLADFLLNAVRFTpsPGGWVEIKVSPTKKQigdgvHVIHLEFRITHPGQGLPEELVQEMFEE-------NQWT 75

                          90       100
                  ....*....|....*....|.
gi 2127773551 631 ---GLGLFIAQRIVGAMNGEL 648
Cdd:cd16932    76 tqeGLGLSISRKLVKLMNGDV 96

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

436-636

5.46e-06

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 49.55 E-value: 5.46e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 436 ALQEVKTHmQQKIetLGYVSHDLRAPLSTihgyakllLQTATP------GQARLIRSIDRSIRYQLTLIDELLQYTRAEL 509
Cdd:PRK09470  235 ALERMMTS-QQRL--LSDISHELRTPLTR--------LQLATAllrrrqGESKELERIETEAQRLDSMINDLLVLSRNQQ 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 510 QpLGIAPDATDLPGLLDDIGDYALALCAQQNNRFDYrplTPLPRKLTIDGIR--LQQVLLNLLSNASKFTRDgTVTLSIG 587
Cdd:PRK09470  304 K-NHLERETFKANSLWSEVLEDAKFEAEQMGKSLTV---SAPPGPWPINGNPnaLASALENIVRNALRYSHT-KIEVAFS 378

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2127773551 588 AYRQagawRLVFEVADTGIGIELDQTTDIFRAYQQVQAV----NGGTGLGLFI 636
Cdd:PRK09470  379 VDKD----GLTITVDDDGPGVPEEEREQIFRPFYRVDEArdreSGGTGLGLAI 427

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

578-664

5.52e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 49.63 E-value: 5.52e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 578 RDGTVTLSIGAYRQAGawRLVFEVADTGIGIELDQTTDIFRAYQQvqaVNGGTGLGLFIAQRIVGAMNGE---LAVSSQP 654
Cdd:COG2972   356 KEGGGTIRISIRKEGD--RLVITVEDNGVGMPEEKLEKLLEELSS---KGEGRGIGLRNVRERLKLYYGEeygLEIESEP 430

                          90
                  ....*....|
gi 2127773551 655 GVGTSFTFQI 664
Cdd:COG2972   431 GEGTTVTIRI 440

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-664

5.76e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 46.03 E-value: 5.76e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTVTLSIGayRQAGAWRLVFEVADTGIGIELDQTTDIF-RAYQQ---VQAVNGGTGLGLFIA 637
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTGRITVS--AMPTGKMVTISVEDEGPGIPQEKLESIFdRFYTErpaNEAFGQHSGLGLSIS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2127773551 638 QRIVGAMNGELAVS--SQPGV--GTSFTFQI 664
Cdd:cd16953    79 RQIIEAHGGISVAEnhNQPGQviGARFTVQL 109

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-654

1.26e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 45.32 E-value: 1.26e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTrDGTVTLSigAYRQAGAWRLVfeVADTGIGIELDQTTDIFRAYQQVQAVNGGTGLGLFIAQRIV 641
Cdd:cd16954    38 LMELLGNLLDNACKWC-LEFVEVT--ARQTDGGLHLI--VDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIV 112

                          90
                  ....*....|...
gi 2127773551 642 GAMNGELAVSSQP 654
Cdd:cd16954   113 EQYGGELSLSDSP 125

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

580-664

1.70e-05

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 46.04 E-value: 1.70e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 580 GTVTLSigAYRQAGawRLVFEVADTGIGI------------------ELDQTTD------IFRA----YQQVQAVNGgTG 631
Cdd:cd16916    70 GTITLR--AEHQGN--QVVIEVSDDGRGIdrekirekaierglitadEAATLSDdevlnlIFAPgfstAEQVTDVSG-RG 144

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2127773551 632 LGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:cd16916   145 VGMDVVKRSIESLGGTIEVESEPGQGTTFTIRL 177

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

558-662

3.25e-05

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 47.07 E-value: 3.25e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFTRDG-TVTLSIGayRQAGAWRLVfeVADTGIGIELDQTTDIFRAYQQV----QAVNGGTGL 632
Cdd:PRK09835  372 DPLMLRRAISNLLSNALRYTPAGeAITVRCQ--EVDHQVQLV--VENPGTPIAPEHLPRLFDRFYRVdpsrQRKGEGSGI 447

                          90       100       110
                  ....*....|....*....|....*....|
gi 2127773551 633 GLFIAQRIVGAMNGELAVSSQPgVGTSFTF 662
Cdd:PRK09835  448 GLAIVKSIVVAHKGTVAVTSDA-RGTRFVI 476

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

558-657

9.62e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 42.14 E-value: 9.62e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 558 DGIRLQQVLLNLLSNASKFTRD-----GTVTLSIGAYRQAgawRLVFEVADTGIGIELDQTTDIFRAYqqVQAVNGGTGL 632
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIEGrpsdvGEVRIRVEADQDG---RIVLIVCDNGKGFPREMRHRATEPY--VTTRPKGTGL 75

                          90       100
                  ....*....|....*....|....*
gi 2127773551 633 GLFIAQRIVGAMNGELAVSSQPGVG 657
Cdd:cd16944    76 GLAIVKKIMEEHGGRISLSNREAGG 100

CheA

COG0643

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

580-696

1.11e-04

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.56 E-value: 1.11e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 580 GTVTLSigAYRQAGawRLVFEVADTGIGI------------------ELDQTTD------IFRA----YQQVQAVNGgTG 631
Cdd:COG0643   309 GTITLS--AYHEGG--RVVIEVSDDGRGLdlekirakaiekglitaeEAAALSDeellelIFAPgfstAEEVTDLSG-RG 383

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2127773551 632 LGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI-----VAPAL----GHAL--IPASALARTVQ-PAEQIDLLADAR 696
Cdd:COG0643   384 VGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLpltlaIIDGLlvrvGGETyaIPLSSVEEVLRlDPDDIETVEGRE 460

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-655

2.88e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 40.91 E-value: 2.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRD-GTVTLSIgayrQAGAWRLVFEVADTGIGI---ELDQTTDIFRAYQQVQAVNGGTGLGLFIA 637
Cdd:cd16945     5 LRQAINNLLDNAIDFSPEgGLIALQL----EADTEGIELLVFDEGSGIpdyALNRVFERFYSLPRPHSGQKSTGLGLAFV 80

                          90
                  ....*....|....*...
gi 2127773551 638 QRIVGAMNGELAVSSQPG 655
Cdd:cd16945    81 QEVAQLHGGRITLRNRPD 98

PRK10337

sensor protein QseC; Provisional

456-657

3.81e-04

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 43.87 E-value: 3.81e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 456 HDLRAPLstihgyAKLLLQT------ATPGQAR------LIRSIDRSIRyqltLIDELLQYTR--AELQPLGIAPDATD- 520
Cdd:PRK10337  246 HELRSPL------AALKVQTevaqlsDDDPQARkkallqLHAGIDRATR----LVDQLLTLSRldSLDNLQDVAEIPLEd 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 521 -LPGLLDDIgdYALALCAQQNNRFDYrPLTPLPRklTIDGIRLQQVLLNLLSNASKFT-RDGTVTLSIGAYRqagawrlv 598
Cdd:PRK10337  316 lLQSAVMDI--YHTAQQAGIDVRLTL-NAHPVIR--TGQPLLLSLLVRNLLDNAIRYSpQGSVVDVTLNARN-------- 382

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2127773551 599 FEVADTGIGIELDQTTDI----FRAYQQVQAvngGTGLGLFIAQRIVGAMNGELAVSSQPGVG 657
Cdd:PRK10337  383 FTVRDNGPGVTPEALARIgerfYRPPGQEAT---GSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

469-664

1.82e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 40.76 E-value: 1.82e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 469 AKLLLQTAtpgqARLIRSIDRSIRYQLTLIDELLQYTRAELQPL--GIAPDATDLPGLLDDIGDYALALCAQQNNRFDYR 546
Cdd:COG4585    72 IKLQLEAA----RRLLDADPEAAREELEEIRELAREALAELRRLvrGLRPPALDDLGLAAALEELAERLLRAAGIRVELD 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 547 ---PLTPLPRKLTIDgirLQQVLLNLLSNASKFTRDGTVTLSIGAYRQagawRLVFEVADTGIGIELDQTTdifrayqqv 623
Cdd:COG4585   148 vdgDPDRLPPEVELA---LYRIVQEALTNALKHAGATRVTVTLEVDDG----ELTLTVRDDGVGFDPEAAP--------- 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2127773551 624 qavngGTGLGLFIAQRIVGAMNGELAVSSQPGVGTSFTFQI 664
Cdd:COG4585   212 -----GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

562-653

1.93e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 38.52 E-value: 1.93e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2127773551 562 LQQVLLNLLSNASKFTRDGTvTLSIGAYRQAGAWRLvfEVADTGIGIELDQTTDIF-RAYQQVQAVN-GGTGLGLFIAQR 639
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENT-RIYITSFLTDDVVNI--MFKNPSSHPLDFKLEKLFeRFYRGDNSRNtEGAGLGLSIAKA 77

                          90
                  ....*....|....
gi 2127773551 640 IVGAMNGELAVSSQ 653
Cdd:cd16923    78 IIELHGGSASAEYD 91

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01