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Conserved domains on  [gi|212725475|ref|YP_002317228|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Gasterosteus wheatlandi]

Protein Classification

NADH-ubiquinone oxidoreductase subunit 4L( domain architecture ID 10009576)

NADH-ubiquinone oxidoreductase subunit 4L (ND4L) is core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.41e-47

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177185  Cd Length: 98  Bit Score: 146.65  E-value: 1.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.41e-47

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 146.65  E-value: 1.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-98 1.19e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 55.65  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  11 AFMLGLTGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVAAARTHGTDHL 90
Cdd:pfam00420  9 LFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDV 87


                 ....*...
gi 212725475  91 QNLNLLQC 98
Cdd:pfam00420 88 DSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.41e-47

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 146.65  E-value: 1.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.91e-34

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 113.16  E-value: 2.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.51e-31

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 105.70  E-value: 2.51e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.68e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 83.44  E-value: 1.68e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 212725475 81 AARTHGTDHLQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 2.23e-17

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 70.36  E-value: 2.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  5 HFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVAAART 84
Cdd:MTH00181  2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                        90
                ....*....|..
gi 212725475 85 HGTDHLQNLNLL 96
Cdd:MTH00181 82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.79e-13

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 60.32  E-value: 1.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 212725475 81 AARTHGTDHLQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-98 1.19e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 55.65  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  11 AFMLGLTGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGAPMLLLAFSACEASAGLALLVAAARTHGTDHL 90
Cdd:pfam00420  9 LFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDV 87


                 ....*...
gi 212725475  91 QNLNLLQC 98
Cdd:pfam00420 88 DSLNLLKG 95
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 12-98 3.38e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.19  E-value: 3.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475 12 FMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSGapMLLLAFSACEASAGLALLVAAARTHGTDHLQ 91
Cdd:MTH00188 13 VVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIRSHGSDYVS 90


                ....*..
gi 212725475 92 NLNLLQC 98
Cdd:MTH00188 91 SLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.41e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 37.52  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSLFIAL-SLWTLQLDSTNFSgapMLLLAFSACEASAGLALLV 79
Cdd:MTH00149  2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMfSSSGLISFSSYLF---LIILTFGACEASLGLSLLV 78

                        90
                ....*....|....*....
gi 212725475 80 AAARTHGTDHLQNLNLLQC 98
Cdd:MTH00149 79 SLIRLHGNDYVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 1.91e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 36.67  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475 12 FMLGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSgaPMLLLAFSACEASAGLALLVAAARTHGTDHLQ 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYF--LLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 212725475 92 N 92
Cdd:MTH00162 89 S 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 3.35e-03

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 33.96  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212725475  1 MTPVHFAFSSAFMLGLTGLAFHRTHLLSALLCLEGMMLSL--FIALSLWTLQLDSTNFSgapMLLLAFSACEASAGLALL 78
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLalFIPLSLMFANQVNGMLA---IVLLTFGACEASLGLSLL 77

                        90       100
                ....*....|....*....|
gi 212725475 79 VAAARTHGTDHLQNLNLLQC 98
Cdd:MTH00013 78 VLMTRSYGNDMLKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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