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Conserved domains on  [gi|212721330|ref|NP_001132883|]
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Zinc finger CCCH domain-containing protein 12 [Zea mays]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 10457906)

zinc finger CCCH domain-containing protein similar to Homo sapiens proline-rich protein 3 (PRR3)

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
363-388 2.18e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.80  E-value: 2.18e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  363 PGEELCKFYSRYGICKFGANCKFDHP 388
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
120-145 2.50e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.42  E-value: 2.50e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  120 GQPECQYYLKTGTCKFGPTCKFHHPR 145
Cdd:pfam00642   2 KTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
317-343 1.17e-06

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 44.49  E-value: 1.17e-06
                          10        20
                  ....*....|....*....|....*..
gi 212721330  317 PDEPECQYYMKTGDCKFGAVCKFHHPR 343
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
74-100 2.07e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 41.02  E-value: 2.07e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330   74 PGEPDCTYYLRTGLCRFGMSCRFNHPP 100
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
165-191 5.40e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.87  E-value: 5.40e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330  165 PNEKECAYYLKTGHCKYANTCKFHHPE 191
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
 
Name Accession Description Interval E-value
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
363-388 2.18e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.80  E-value: 2.18e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  363 PGEELCKFYSRYGICKFGANCKFDHP 388
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
120-145 2.50e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.42  E-value: 2.50e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  120 GQPECQYYLKTGTCKFGPTCKFHHPR 145
Cdd:pfam00642   2 KTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
317-343 1.17e-06

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 44.49  E-value: 1.17e-06
                          10        20
                  ....*....|....*....|....*..
gi 212721330  317 PDEPECQYYMKTGDCKFGAVCKFHHPR 343
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
74-100 2.07e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 41.02  E-value: 2.07e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330   74 PGEPDCTYYLRTGLCRFGMSCRFNHPP 100
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
165-191 5.40e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.87  E-value: 5.40e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330  165 PNEKECAYYLKTGHCKYANTCKFHHPE 191
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
362-388 5.60e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 5.60e-04
                           10        20
                   ....*....|....*....|....*..
gi 212721330   362 RPGEELCKFYsRYGICKFGANCKFDHP 388
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
120-145 1.91e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 35.68  E-value: 1.91e-03
                           10        20
                   ....*....|....*....|....*.
gi 212721330   120 GQPECQYYlKTGTCKFGPTCKFHHPR 145
Cdd:smart00356   3 KTELCKFF-KRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
363-388 2.18e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.80  E-value: 2.18e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  363 PGEELCKFYSRYGICKFGANCKFDHP 388
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
120-145 2.50e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 46.42  E-value: 2.50e-07
                          10        20
                  ....*....|....*....|....*.
gi 212721330  120 GQPECQYYLKTGTCKFGPTCKFHHPR 145
Cdd:pfam00642   2 KTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
317-343 1.17e-06

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 44.49  E-value: 1.17e-06
                          10        20
                  ....*....|....*....|....*..
gi 212721330  317 PDEPECQYYMKTGDCKFGAVCKFHHPR 343
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
74-100 2.07e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 41.02  E-value: 2.07e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330   74 PGEPDCTYYLRTGLCRFGMSCRFNHPP 100
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
165-191 5.40e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.87  E-value: 5.40e-05
                          10        20
                  ....*....|....*....|....*..
gi 212721330  165 PNEKECAYYLKTGHCKYANTCKFHHPE 191
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
362-388 5.60e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 5.60e-04
                           10        20
                   ....*....|....*....|....*..
gi 212721330   362 RPGEELCKFYsRYGICKFGANCKFDHP 388
Cdd:smart00356   1 KYKTELCKFF-KRGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
120-145 1.91e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 35.68  E-value: 1.91e-03
                           10        20
                   ....*....|....*....|....*.
gi 212721330   120 GQPECQYYlKTGTCKFGPTCKFHHPR 145
Cdd:smart00356   3 KTELCKFF-KRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 368-387 5.58e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 33.93  E-value: 5.58e-03
                          10        20
                  ....*....|....*....|
gi 212721330  368 CKFYSRyGICKFGANCKFDH 387
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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