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Conserved domains on  [gi|2125241216|ref|XP_044766530|]
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heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Coccinella septempunctata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY super family cl02614
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 205-544 4.04e-44

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


The actual alignment was detected with superfamily member cd12884:

Pssm-ID: 470632  Cd Length: 177  Bit Score: 157.36  E-value: 4.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 205 VLLSWYDSDLHLLVDKQSFlSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEmswedftnqrrerqerakerrek 284
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 285 ekqrlksssdkndtgekdskieekdteekpkdikmevseekqsdekpVDVKMEVSEEKTneeenptdindkdqtnetees 364
Cdd:cd12884    57 -----------------------------------------------LPVKHLPTEETD--------------------- 68

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 365 kvkteetdikpeestepspveenqdkesseskadesekssenkvedetpneekkensekksddpstpilTHIFRTGWSVE 444
Cdd:cd12884    69 ---------------------------------------------------------------------PHVVRVGWSVD 79

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 445 KSSLQLGEDNFSYGYESTGKLVANKEFNDFGGSYKLGDVVGAYLNISNENVEMRFTVNGELQPEVKSIPRSEFpqENLVL 524
Cdd:cd12884    80 SSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEEL--GGKAL 157

                         330       340
                  ....*....|....*....|
gi 2125241216 525 FPHVLSRNFSFELNLGSKEE 544
Cdd:cd12884   158 FPHVLTKNCAVEVNFGQKEE 177
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 580-725 3.80e-24

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 98.92  E-value: 3.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 580 VIMMCGLPGSGKTHWVNEYLRSNNdklTNVIGATHLLERMTVHGQPLKSTYNGQWnmlmEKLQRCLNRLGDIAAQRRRNY 659
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDAT----DRTYERLHELARIALRAGRPV 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 660 ILDQTNVFPSAQHRKLRAFE--GFKRRAVVVVVGDEEFAKRQSLKEAA--VGKDVHEYTIMEMKANMALP 725
Cdd:pfam13671  74 ILDATNLRRDERARLLALAReyGVPVRIVVFEAPEEVLRERLAARARAggDPSDVPEEVLDRQKARFEPP 143
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-41 8.28e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


:

Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.19  E-value: 8.28e-12
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2125241216    8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKAL 41
Cdd:smart00513   2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
PTZ00121 super family cl31754
MAEBL; Provisional
 35-411 2.04e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   35 KRLKKALEEELNKELPDTSIADTSTEDFDSSRVEESSKNEVEVEPEA--ESESESKPVADQKDDDVSSQMTVEEPNDSSK 112
Cdd:PTZ00121  1146 RKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEElrKAEDARKAEAARKAEEERKAEEARKAEDAKK 1225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  113 IAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGECSESNDVEMK-EVSTDVEDNQKGEKRKRTDDSSEQIQKKRPF 191
Cdd:PTZ00121  1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKaEEARKADELKKAEEKKKADEAKKAEEKKKAD 1305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  192 KVTEDEPEIDPSKVLLSWYDSdlhllVDKQSFLSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEMSWEDFTNQR 271
Cdd:PTZ00121  1306 EAKKKAEEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA 1380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  272 RERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKdteEKPKDIKMEVSEEKQSDE--------KPVDVKMEVSEEKT 343
Cdd:PTZ00121  1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAK---KKADEAKKKAEEKKKADEakkkaeeaKKADEAKKKAEEAK 1457

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125241216  344 NEEENPTDINDKDQTNETE---ESKVKTEETDIKPEESTEPSpvEENQDKESSESKADESEKSSENKVEDE 411
Cdd:PTZ00121  1458 KAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEEAKKKA--DEAKKAAEAKKKADEAKKAEEAKKADE 1526
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 205-544 4.04e-44

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 157.36  E-value: 4.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 205 VLLSWYDSDLHLLVDKQSFlSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEmswedftnqrrerqerakerrek 284
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 285 ekqrlksssdkndtgekdskieekdteekpkdikmevseekqsdekpVDVKMEVSEEKTneeenptdindkdqtnetees 364
Cdd:cd12884    57 -----------------------------------------------LPVKHLPTEETD--------------------- 68

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 365 kvkteetdikpeestepspveenqdkesseskadesekssenkvedetpneekkensekksddpstpilTHIFRTGWSVE 444
Cdd:cd12884    69 ---------------------------------------------------------------------PHVVRVGWSVD 79

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 445 KSSLQLGEDNFSYGYESTGKLVANKEFNDFGGSYKLGDVVGAYLNISNENVEMRFTVNGELQPEVKSIPRSEFpqENLVL 524
Cdd:cd12884    80 SSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEEL--GGKAL 157

                         330       340
                  ....*....|....*....|
gi 2125241216 525 FPHVLSRNFSFELNLGSKEE 544
Cdd:cd12884   158 FPHVLTKNCAVEVNFGQKEE 177
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 580-725 3.80e-24

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 98.92  E-value: 3.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 580 VIMMCGLPGSGKTHWVNEYLRSNNdklTNVIGATHLLERMTVHGQPLKSTYNGQWnmlmEKLQRCLNRLGDIAAQRRRNY 659
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDAT----DRTYERLHELARIALRAGRPV 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 660 ILDQTNVFPSAQHRKLRAFE--GFKRRAVVVVVGDEEFAKRQSLKEAA--VGKDVHEYTIMEMKANMALP 725
Cdd:pfam13671  74 ILDATNLRRDERARLLALAReyGVPVRIVVFEAPEEVLRERLAARARAggDPSDVPEEVLDRQKARFEPP 143
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-41 8.28e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.19  E-value: 8.28e-12
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2125241216    8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKAL 41
Cdd:smart00513   2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 8-41 3.13e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.57  E-value: 3.13e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2125241216   8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKAL 41
Cdd:pfam02037   2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
COG4639 COG4639
Predicted kinase [General function prediction only];
577-735 1.65e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 54.45  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 577 ECEVIMMCGLPGSGKTHWVNEYLrsnndKLTNVIGATHLleRMTVHGQPLKSTYNGQ-WNMLMEKLQRCLnrlgdiaaQR 655
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLF-----APTEVVSSDDI--RALLGGDENDQSAWGDvFQLAHEIARARL--------RA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 656 RRNYILDQTNVfpSAQHRK--LRAFEGFKRRAVVVV--VGDEEFAKRQSLKEAAVGKDVheytIMEMKANM-ALPTKGEL 730
Cdd:COG4639    66 GRLTVVDATNL--QREARRrlLALARAYGALVVAVVldVPLEVCLARNAARDRQVPEEV----IRRMLRRLrRPPLPEEG 139


                  ....*
gi 2125241216 731 FDEVL 735
Cdd:COG4639   140 FRVVY 144
PTZ00121 PTZ00121
MAEBL; Provisional
 35-411 2.04e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   35 KRLKKALEEELNKELPDTSIADTSTEDFDSSRVEESSKNEVEVEPEA--ESESESKPVADQKDDDVSSQMTVEEPNDSSK 112
Cdd:PTZ00121  1146 RKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEElrKAEDARKAEAARKAEEERKAEEARKAEDAKK 1225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  113 IAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGECSESNDVEMK-EVSTDVEDNQKGEKRKRTDDSSEQIQKKRPF 191
Cdd:PTZ00121  1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKaEEARKADELKKAEEKKKADEAKKAEEKKKAD 1305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  192 KVTEDEPEIDPSKVLLSWYDSdlhllVDKQSFLSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEMSWEDFTNQR 271
Cdd:PTZ00121  1306 EAKKKAEEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA 1380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  272 RERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKdteEKPKDIKMEVSEEKQSDE--------KPVDVKMEVSEEKT 343
Cdd:PTZ00121  1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAK---KKADEAKKKAEEKKKADEakkkaeeaKKADEAKKKAEEAK 1457

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125241216  344 NEEENPTDINDKDQTNETE---ESKVKTEETDIKPEESTEPSpvEENQDKESSESKADESEKSSENKVEDE 411
Cdd:PTZ00121  1458 KAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEEAKKKA--DEAKKAAEAKKKADEAKKAEEAKKADE 1526
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 434-541 1.95e-06

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 47.67  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  434 THIFRTGWSVEKSSL----QLGEDNFSYGYEST-GKLVANKEFNDFGGSYKL-GDVVGAYLNISNEnvEMRFTVNGELQP 507
Cdd:smart00449  13 GGHWRVGVATKSVPRgyfaLLGEDKGSWGYDGDgGKKYHNSTGPEYGLPLQEpGDVIGCFLDLEAG--TISFYKNGKYLH 90

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2125241216  508 EVkSIPRSEFPQEnlvLFPHVLSRNF-SFELNLGS 541
Cdd:smart00449  91 GL-AFFDVKFSGP---LYPAFSLGSGnSVRLNFGP 121
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 109-413 6.96e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.99  E-value: 6.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  109 DSSK--IAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGEcseSNDVEMKEVSTDVEDNQKGEkrkrTDDSSEQIQ 186
Cdd:TIGR00927  629 DLSKgdVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGE---TETKGENESEGEIPAERKGE----QEGEGEIEA 701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  187 KKRPFKVTEDEPEIDpskvllswydsdlhllvdkqsflsakplheglfgyAWAGVRATHGINSGKVRYEVKLTQEMSWED 266
Cdd:TIGR00927  702 KEADHKGETEAEEVE-----------------------------------HEGETEAEGTEDEGEIETGEEGEEVEDEGE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  267 FTNQRRERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEK-----DTEEKPKDIKMEVSEEKQSDEKPVDVKMEVSEE 341
Cdd:TIGR00927  747 GEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDgemkgDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2125241216  342 KTNEEENPTDINDKDQTNETEESK-VKTEETDIKPEESTEPSPVEENQDKESSESKADESEKSSENKVEDETP 413
Cdd:TIGR00927  827 EVKDETGEQELNAENQGEAKQDEKgVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLEWP 899
Caldesmon pfam02029
Caldesmon;
270-427 1.68e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 45.24  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 270 QRRERQERAKERREKEK-------------------QRLKSSSDKNDTGEKD-SKIEEKDTEEKPKDIKMEVSEEKQSDE 329
Cdd:pfam02029  12 RRRAREERRRQKEEEEPsgqvtesvepnehnsyeedSELKPSGQGGLDEEEAfLDRTAKREERRQKRLQEALERQKEFDP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 330 KPVDVKMEVSEEKTNEEENPTDINDKDQTNETEESKVKTEETDIKPEEstepspvEENQDKESSESKADESEKSSENKVE 409
Cdd:pfam02029  92 TIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKE-------YQENKWSTEVRQAEEEGEEEEDKSE 164

                         170
                  ....*....|....*...
gi 2125241216 410 DETPNEEKKENSEKKSDD 427
Cdd:pfam02029 165 EAEEVPTENFAKEEVKDE 182
pseT PHA02530
polynucleotide kinase; Provisional
 577-724 1.37e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 41.93  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 577 ECEVIMMCGLPGSGKTHWVNEYLRSNNDklTNVIGATHLleRMTVHGQPLKSTYNGqwNMLMEKLQRCLNRLGDIAAQRR 656
Cdd:PHA02530    1 MMKIILTVGVPGSGKSTWAREFAAKNPK--AVNVNRDDL--RQSLFGHGEWGEYKF--TKEKEDLVTKAQEAAALAALKS 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2125241216 657 -RNYILDQTNVFPSAQH--RKLRAFEGFKRRAVVVVVGDEEFAKRQSLK-EAAVGKDVHEYTIMEMKANMAL 724
Cdd:PHA02530   75 gKSVIISDTNLNPERRRkwKELAKELGAEFEEKVFDVPVEELVKRNRKRgERAVPEDVLRSMFKQMKEYRGL 146
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 6-69 5.52e-03

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 40.59  E-value: 5.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2125241216   6 DPSKLKVSELREELQARGLDTKGNKPVLVKRLKKALEEELNKELPDTSIADTSTEDFDSSRVEE 69
Cdd:PLN03124   78 EVKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKVGSANGTGEDEKEKGGDEEREKE 141
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 205-544 4.04e-44

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 157.36  E-value: 4.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 205 VLLSWYDSDLHLLVDKQSFlSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEmswedftnqrrerqerakerrek 284
Cdd:cd12884     1 VCLDTYNSDLHLKISKDRY-SASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTEN----------------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 285 ekqrlksssdkndtgekdskieekdteekpkdikmevseekqsdekpVDVKMEVSEEKTneeenptdindkdqtnetees 364
Cdd:cd12884    57 -----------------------------------------------LPVKHLPTEETD--------------------- 68

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 365 kvkteetdikpeestepspveenqdkesseskadesekssenkvedetpneekkensekksddpstpilTHIFRTGWSVE 444
Cdd:cd12884    69 ---------------------------------------------------------------------PHVVRVGWSVD 79

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 445 KSSLQLGEDNFSYGYESTGKLVANKEFNDFGGSYKLGDVVGAYLNISNENVEMRFTVNGELQPEVKSIPRSEFpqENLVL 524
Cdd:cd12884    80 SSSLQLGEEEFSYGYGSTGKKSTNCKFEDYGEPFGENDVIGCYLDFESEPVEISFSKNGKDLGVAFKISKEEL--GGKAL 157

                         330       340
                  ....*....|....*....|
gi 2125241216 525 FPHVLSRNFSFELNLGSKEE 544
Cdd:cd12884   158 FPHVLTKNCAVEVNFGQKEE 177
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 580-725 3.80e-24

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 98.92  E-value: 3.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 580 VIMMCGLPGSGKTHWVNEYLRSNNdklTNVIGATHLLERMTVHGQPLKSTYNGQWnmlmEKLQRCLNRLGDIAAQRRRNY 659
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLFGEGRPSISYYTDAT----DRTYERLHELARIALRAGRPV 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 660 ILDQTNVFPSAQHRKLRAFE--GFKRRAVVVVVGDEEFAKRQSLKEAA--VGKDVHEYTIMEMKANMALP 725
Cdd:pfam13671  74 ILDATNLRRDERARLLALAReyGVPVRIVVFEAPEEVLRERLAARARAggDPSDVPEEVLDRQKARFEPP 143
SPRY_DDX1 cd12873
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ...
 438-542 1.52e-20

SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay.


Pssm-ID: 293933  Cd Length: 155  Bit Score: 89.17  E-value: 1.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 438 RTGWSVEKSSLQLGEDNFSYGYESTGKLVANKEFNDFGGSYKLGDVVGAYLNISNEnvEMRFTVNGELQPEVKSIPrseF 517
Cdd:cd12873    55 RVGWSTEDASLDLGTDKFGFGYGGTGKKSHGRQFDDYGEPFGLGDVIGCYLDLDNG--TISFSKNGKDLGKAFDIP---P 129

                          90       100
                  ....*....|....*....|....*
gi 2125241216 518 PQENLVLFPHVLSRNFSFELNLGSK 542
Cdd:cd12873   130 HLRNSALFPAVCLKNAEVEFNFGDK 154
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
8-41 8.28e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.19  E-value: 8.28e-12
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2125241216    8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKAL 41
Cdd:smart00513   2 AKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 8-41 3.13e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.57  E-value: 3.13e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2125241216   8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKAL 41
Cdd:pfam02037   2 SKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
COG4639 COG4639
Predicted kinase [General function prediction only];
577-735 1.65e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 54.45  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 577 ECEVIMMCGLPGSGKTHWVNEYLrsnndKLTNVIGATHLleRMTVHGQPLKSTYNGQ-WNMLMEKLQRCLnrlgdiaaQR 655
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLF-----APTEVVSSDDI--RALLGGDENDQSAWGDvFQLAHEIARARL--------RA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 656 RRNYILDQTNVfpSAQHRK--LRAFEGFKRRAVVVV--VGDEEFAKRQSLKEAAVGKDVheytIMEMKANM-ALPTKGEL 730
Cdd:COG4639    66 GRLTVVDATNL--QREARRrlLALARAYGALVVAVVldVPLEVCLARNAARDRQVPEEV----IRRMLRRLrRPPLPEEG 139


                  ....*
gi 2125241216 731 FDEVL 735
Cdd:COG4639   140 FRVVY 144
PTZ00121 PTZ00121
MAEBL; Provisional
 35-411 2.04e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   35 KRLKKALEEELNKELPDTSIADTSTEDFDSSRVEESSKNEVEVEPEA--ESESESKPVADQKDDDVSSQMTVEEPNDSSK 112
Cdd:PTZ00121  1146 RKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEElrKAEDARKAEAARKAEEERKAEEARKAEDAKK 1225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  113 IAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGECSESNDVEMK-EVSTDVEDNQKGEKRKRTDDSSEQIQKKRPF 191
Cdd:PTZ00121  1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKaEEARKADELKKAEEKKKADEAKKAEEKKKAD 1305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  192 KVTEDEPEIDPSKVLLSWYDSdlhllVDKQSFLSAKPLHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEMSWEDFTNQR 271
Cdd:PTZ00121  1306 EAKKKAEEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA 1380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  272 RERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKdteEKPKDIKMEVSEEKQSDE--------KPVDVKMEVSEEKT 343
Cdd:PTZ00121  1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAK---KKADEAKKKAEEKKKADEakkkaeeaKKADEAKKKAEEAK 1457

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2125241216  344 NEEENPTDINDKDQTNETE---ESKVKTEETDIKPEESTEPSpvEENQDKESSESKADESEKSSENKVEDE 411
Cdd:PTZ00121  1458 KAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEEAKKKA--DEAKKAAEAKKKADEAKKAEEAKKADE 1526
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 8-161 2.17e-07

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 54.84  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   8 SKLKVSELREELQARGLDTKGNKPVLVKRLKKALEEElnkelpdtsIADTSTEDFDSSRVEESSKNEVEVEPEAESESES 87
Cdd:PLN03124    3 NKLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAED---------AKTASKSGTKSSAGRKKRRERQDDGDDEPVSPKR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2125241216  88 KPVADQKDddvssqMTVEEPNDSSKIAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGECSESNDVEMKE 161
Cdd:PLN03124   74 IAIDEVKG------MTVRELREAASERGLATTGRKKDLLERLCAALESDVKVGSANGTGEDEKEKGGDEEREKE 141
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 435-506 9.96e-07

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 49.44  E-value: 9.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 435 HIfRTGWSVEKSSLQ--LGEDNFSYGY---------ESTGKLVANKEFndfggsyKLGDVVGAYLNISnenvEMRFTVNG 503
Cdd:cd12872    46 HV-RVGWSRREASLQapVGYDKYSYAIrdkdgskfhQSRGKPYGEPGF-------KEGDVIGFLITLP----KIEFFKNG 113


                  ...
gi 2125241216 504 ELQ 506
Cdd:cd12872   114 KSQ 116
PTZ00121 PTZ00121
MAEBL; Provisional
 17-411 1.10e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   17 EELQARGLDTKGNKPVLVKRLKKALEEELNKELPDTSIADTSTEDFDSSRVEESSKNEVEVEPEAESESESKPVADQKDD 96
Cdd:PTZ00121  1421 DEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   97 DVSSQMTVEEPNDSSKIAEPSDNNENTDDKEEVPNSESNENKEEIQddqeKQGECSESNDVEMKEVSTDVEDNQKGEKRK 176
Cdd:PTZ00121  1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKK----KADELKKAEELKKAEEKKKAEEAKKAEEDK 1576

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  177 ----RTDDSSEQIQKKRPFKVTEDEPEIDPSKVllswydsdlhllvdkqsflsakplhEGLFGYAWAGVRATHGINSGKV 252
Cdd:PTZ00121  1577 nmalRKAEEAKKAEEARIEEVMKLYEEEKKMKA-------------------------EEAKKAEEAKIKAEELKKAEEE 1631

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  253 RYEVkltqemswEDFTNQRRERQERAKE-RREKEKQRLKSSSDKNDTGEKDSKIEEKDTEEKPKDIKMEVSEEKQSDEKP 331
Cdd:PTZ00121  1632 KKKV--------EQLKKKEAEEKKKAEElKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKK 1703

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  332 VD-VKMEVSEEKTNEEEnptdindkdQTNETEESKVKTEETDIKPEE---STEPSPVEENQDKESSESKADESEKSSENK 407
Cdd:PTZ00121  1704 AEeLKKKEAEEKKKAEE---------LKKAEEENKIKAEEAKKEAEEdkkKAEEAKKDEEEKKKIAHLKKEEEKKAEEIR 1774


                   ....
gi 2125241216  408 VEDE 411
Cdd:PTZ00121  1775 KEKE 1778
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 434-541 1.95e-06

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 47.67  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  434 THIFRTGWSVEKSSL----QLGEDNFSYGYEST-GKLVANKEFNDFGGSYKL-GDVVGAYLNISNEnvEMRFTVNGELQP 507
Cdd:smart00449  13 GGHWRVGVATKSVPRgyfaLLGEDKGSWGYDGDgGKKYHNSTGPEYGLPLQEpGDVIGCFLDLEAG--TISFYKNGKYLH 90

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2125241216  508 EVkSIPRSEFPQEnlvLFPHVLSRNF-SFELNLGS 541
Cdd:smart00449  91 GL-AFFDVKFSGP---LYPAFSLGSGnSVRLNFGP 121
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 109-413 6.96e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.99  E-value: 6.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  109 DSSK--IAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGEcseSNDVEMKEVSTDVEDNQKGEkrkrTDDSSEQIQ 186
Cdd:TIGR00927  629 DLSKgdVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGE---TETKGENESEGEIPAERKGE----QEGEGEIEA 701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  187 KKRPFKVTEDEPEIDpskvllswydsdlhllvdkqsflsakplheglfgyAWAGVRATHGINSGKVRYEVKLTQEMSWED 266
Cdd:TIGR00927  702 KEADHKGETEAEEVE-----------------------------------HEGETEAEGTEDEGEIETGEEGEEVEDEGE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  267 FTNQRRERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEK-----DTEEKPKDIKMEVSEEKQSDEKPVDVKMEVSEE 341
Cdd:TIGR00927  747 GEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDgemkgDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2125241216  342 KTNEEENPTDINDKDQTNETEESK-VKTEETDIKPEESTEPSPVEENQDKESSESKADESEKSSENKVEDETP 413
Cdd:TIGR00927  827 EVKDETGEQELNAENQGEAKQDEKgVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLEWP 899
SPRY_RanBP_like cd12885
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ...
 449-540 1.08e-05

SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate.


Pssm-ID: 293943  Cd Length: 132  Bit Score: 45.73  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 449 QLGEDNFSYGYE-STGKLVANKEFN-DFGGSYKLGDVVGAYLNISNEnvEMRFTVNGELqpeVKSIPRSEFPQEnlvLFP 526
Cdd:cd12885    45 MPGWEDGSYGYHgDDGRVYLGGGEGeNYGPPFGTGDVVGCGINFKTG--EVFFTKNGEL---LGTAFENVVKGR---LYP 116

                          90
                  ....*....|....*.
gi 2125241216 527 --HVLSRNFSFELNLG 540
Cdd:cd12885   117 tvGLGSPGVKVRVNFG 132
PTZ00121 PTZ00121
MAEBL; Provisional
 8-407 1.39e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216    8 SKLKVSElrEELQARGLDTKGNKPVLVKRLKKALEEElNKELPDTSIADTSTEDFDSSRVEESSKNEVEVEPEAESESES 87
Cdd:PTZ00121  1369 AEKKKEE--AKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKK 1445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   88 KPVADQKDDDVSSQMTVEEPNDSSKIAEPSDNNENTDDKEEVPNSESNENKEEIQDDQEKQGECSESNDVEMKEVSTDVE 167
Cdd:PTZ00121  1446 ADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKAD 1525

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  168 DNQKGEKRKRTDDSSEQIQKKRPFKVTEDEpeidpskvllswydsDLHLLVDKQSFLSAKPLHEGLfGYAWAGVRATHGI 247
Cdd:PTZ00121  1526 EAKKAEEAKKADEAKKAEEKKKADELKKAE---------------ELKKAEEKKKAEEAKKAEEDK-NMALRKAEEAKKA 1589

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  248 NSGKVRYEVKLTQEMSWEDFTNQRRERQER--AKERREKEKQRLKSSSDKNDTGEKDSKIEEKDTEEKPKDIKMEVSEEK 325
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKikAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK 1669

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  326 QSDE--KPVDVKMEVSEEKTNEEENPTDINDK---DQTNETEESKVKTEETDIKPEESTEPSPVEENQDKESSESKADES 400
Cdd:PTZ00121  1670 AEEDkkKAEEAKKAEEDEKKAAEALKKEAEEAkkaEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEA 1749


                   ....*..
gi 2125241216  401 EKSSENK 407
Cdd:PTZ00121  1750 KKDEEEK 1756
Caldesmon pfam02029
Caldesmon;
270-427 1.68e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 45.24  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 270 QRRERQERAKERREKEK-------------------QRLKSSSDKNDTGEKD-SKIEEKDTEEKPKDIKMEVSEEKQSDE 329
Cdd:pfam02029  12 RRRAREERRRQKEEEEPsgqvtesvepnehnsyeedSELKPSGQGGLDEEEAfLDRTAKREERRQKRLQEALERQKEFDP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 330 KPVDVKMEVSEEKTNEEENPTDINDKDQTNETEESKVKTEETDIKPEEstepspvEENQDKESSESKADESEKSSENKVE 409
Cdd:pfam02029  92 TIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKE-------YQENKWSTEVRQAEEEGEEEEDKSE 164

                         170
                  ....*....|....*...
gi 2125241216 410 DETPNEEKKENSEKKSDD 427
Cdd:pfam02029 165 EAEEVPTENFAKEEVKDE 182
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 91-346 2.28e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 2.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   91 ADQKDDDVSSQMTVEEPNDSSKIAEpSDNNENTDDKEEvpNSESNENKEEIQDDQEKQGEC-SESNDVEMKEVSTDVEDN 169
Cdd:TIGR00927  642 GERTGEEGERPTEAEGENGEESGGE-AEQEGETETKGE--NESEGEIPAERKGEQEGEGEIeAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  170 QKGEKRKRTDDSSEQIQKKRPFKVTEDEPEIDPSKVLLSWYDSDLHLLVDKQSFLSAKPLHEGlfgYAWAGVRATHGINS 249
Cdd:TIGR00927  719 GETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEG---EIQAGEDGEMKGDE 795

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  250 GKVRYEVKLTQEMSWEDFTNQRRERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKDTEEKPKDIKMEVSEEKQSDE 329
Cdd:TIGR00927  796 GAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEE 875

                          250
                   ....*....|....*..
gi 2125241216  330 KPVDVKMEVSEEKTNEE 346
Cdd:TIGR00927  876 EEEEEEEEEEEEEENEE 892
SPRY_RING cd12883
SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY ...
 436-533 2.29e-04

SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY domain is found at the N-terminus of RING finger domains which are present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RING-finger domain is a type of Zn-finger that binds two Zn atoms and is identified in proteins with a wide range of functions such as viral replication, signal transduction, and development.


Pssm-ID: 293941  Cd Length: 121  Bit Score: 41.95  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 436 IFRTGWSVEKSSLQ------LGEDNFSYGYESTGKLV---------ANKefndfggSYKLGDVVGAYLNISNEnvEMRFT 500
Cdd:cd12883    14 VMQIGWATKDSKFLnhegygIGDDEYSCAYDGCRQLIwynakskphTHP-------RWKPGDVLGCLLDLNKK--QMIFS 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2125241216 501 VNGELQPEVKSIPRSE----FPQENLVLFPHVlSRNF 533
Cdd:cd12883    85 LNGNRLPPERQVFTSAksgfFAAASFMSFQQC-EFNF 120
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 35-342 3.72e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.60  E-value: 3.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216   35 KRLKKALEEELNKELPDTSIA--DTSTEDFDSSRVEESSKNEVEVEPEAESESESKPVADQKDDDVSSQMTVEEPNDSSK 112
Cdd:TIGR00927  606 KQIELWVKEQLSRRPVAKVMAlgDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEI 685

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  113 IAEPSDNNEN-TDDKEEVPNSESNENKEEIQ---------DDQEKQGECSESNDVEMKEVSTDVEDNQKGEKRKRTDDSS 182
Cdd:TIGR00927  686 PAERKGEQEGeGEIEAKEADHKGETEAEEVEhegeteaegTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETE 765

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  183 EQIQKKRPFKVTEDEPEIDPSKvllswyDSDlhllvdkqsflsakplHEGLFGYAWAGVRATHGINSGKVRYEVKLTQEM 262
Cdd:TIGR00927  766 HEGETEAEGKEDEDEGEIQAGE------DGE----------------MKGDEGAEGKVEHEGETEAGEKDEHEGQSETQA 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  263 SWEDFTNQRRERQERAKERRE-KEKQRLKSSSDKNDTGEKDSKIEEKDTEEKPKDIKMEVSEEKQSDEKPVDVKMEVSEE 341
Cdd:TIGR00927  824 DDTEVKDETGEQELNAENQGEaKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLEWPETRQ 903


                   .
gi 2125241216  342 K 342
Cdd:TIGR00927  904 K 904
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 262-412 3.82e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.60  E-value: 3.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  262 MSWEDFTNQRRERQERAKERREKEKQRLKSSSDKNDT---------GEKDSKIEEKDTEEKPKDIKMEVSEEKQSDEKPV 332
Cdd:TIGR00927  625 MALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEesggeaeqeGETETKGENESEGEIPAERKGEQEGEGEIEAKEA 704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  333 DVKMEVSEEKTNEEENPTDINDKDQtNETEESKVKTEETDIKPEESTEPSPVEENQDKESSESKADESEKSSENKVEDET 412
Cdd:TIGR00927  705 DHKGETEAEEVEHEGETEAEGTEDE-GEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEI 783
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
271-413 4.40e-04

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 43.92  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 271 RRERQERAKERREKEKQRLKSSSDKndTGEKDSKIEEKDTEEKPKDIKMEVSEEKQSdekPVDVKMEVSEEKTNEEENPT 350
Cdd:PRK06347    2 QKTRKERILEALQEEKKNKKSKKFK--TGATIAGVTAIATSITVPGIEVIVSADETA---PADEASKSAEANTTKEAPAT 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2125241216 351 DINDKDQTNETEESKVKTEEtdiKPEESTEPSPVEENQDKESSESKadeSEKSSENKVEDETP 413
Cdd:PRK06347   77 ATPENTTEPTVEPKQTETKE---QTKTPEEKQPAAKQVEKAPAEPA---TVSNPDNATSSSTP 133
CAF-1_p150 pfam11600
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...
 255-378 1.13e-03

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.


Pssm-ID: 402959 [Multi-domain]  Cd Length: 164  Bit Score: 40.83  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 255 EVKLTQEMSWEDFTNQRRERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKDTEEKpkdikmEVSEEKQSDEKPVDV 334
Cdd:pfam11600  11 EEKEKQRLEKDKERLRRQLKLEAEKEEKERLKEEAKAEKERAKEEARRKKEEEKELKEK------ERREKKEKDEKEKAE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2125241216 335 KMEVSEEKTNEEENPTDINDKDQTNETEESKVKTEETDIKPEES 378
Cdd:pfam11600  85 KLRLKEEKRKEKQEALEAKLEEKRKKEEEKRLKEEEKRIKAEKA 128
pseT PHA02530
polynucleotide kinase; Provisional
 577-724 1.37e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 41.93  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 577 ECEVIMMCGLPGSGKTHWVNEYLRSNNDklTNVIGATHLleRMTVHGQPLKSTYNGqwNMLMEKLQRCLNRLGDIAAQRR 656
Cdd:PHA02530    1 MMKIILTVGVPGSGKSTWAREFAAKNPK--AVNVNRDDL--RQSLFGHGEWGEYKF--TKEKEDLVTKAQEAAALAALKS 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2125241216 657 -RNYILDQTNVFPSAQH--RKLRAFEGFKRRAVVVVVGDEEFAKRQSLK-EAAVGKDVHEYTIMEMKANMAL 724
Cdd:PHA02530   75 gKSVIISDTNLNPERRRkwKELAKELGAEFEEKVFDVPVEELVKRNRKRgERAVPEDVLRSMFKQMKEYRGL 146
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 273-410 1.90e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 41.91  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 273 ERQERAKERREKEKQRLKSSSDKNDTGEKDSKIEEKDTEEKPKdikmevsEEKQSdEKPVDVKMEVSEEKTNEEenptdi 352
Cdd:pfam05262 213 KRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQ-------EAKNL-PKPADTSSPKEDKQVAEN------ 278

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2125241216 353 ndkdQTNETEESKVKTEETDIKPEESTEPSPVEENQDKESSESKADESEKSSENKVED 410
Cdd:pfam05262 279 ----QKREIEKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREP 332
rne PRK10811
ribonuclease E; Reviewed
 269-411 2.22e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.95  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  269 NQRRERQERAKERREKEKQRLKSSSD----------KNDTGEKDSKIEEKDTEEKPKDIKMEV---------SEEK--QS 327
Cdd:PRK10811   612 NNRRDRNERRDTRDNRTRREGRENREenrrnrrqaqQQTAETRESQQAEVTEKARTQDEQQQAprrerqrrrNDEKrqAQ 691

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216  328 DEKPVDVKMEVSEEKTNEEENPTDINDKDQTNETE-----ESKVKTEETDIKPEESTEPSPVEENQDKESSESKADESEK 402
Cdd:PRK10811   692 QEAKALNVEEQSVQETEQEERVQQVQPRRKQRQLNqkvriEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPV 771


                   ....*....
gi 2125241216  403 SSENKVEDE 411
Cdd:PRK10811   772 VAQTAPEQD 780
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
580-690 2.29e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.90  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2125241216 580 VIMMCGLPGSGKTHwvneYLRsnndKLTNVIGATHL---LERMTVHGQPLKSTYNGQWnmLMEKLQRCLNRLGDIAAQRR 656
Cdd:COG0645     1 LILVCGLPGSGKST----LAR----ALAERLGAVRLrsdVVRKRLFGAGLAPLERSPE--ATARTYARLLALARELLAAG 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2125241216 657 RNYILDQTnvFPSAQHRKlRAFEGFKRRAVVVVV 690
Cdd:COG0645    71 RSVILDAT--FLRRAQRE-AFRALAEEAGAPFVL 101
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 6-69 5.52e-03

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 40.59  E-value: 5.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2125241216   6 DPSKLKVSELREELQARGLDTKGNKPVLVKRLKKALEEELNKELPDTSIADTSTEDFDSSRVEE 69
Cdd:PLN03124   78 EVKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKVGSANGTGEDEKEKGGDEEREKE 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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