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Conserved domains on  [gi|2124955632|ref|WP_227160446|]
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MULTISPECIES: conjugal transfer protein [Bacillota]

Protein Classification

conjugal transfer protein( domain architecture ID 10576919)

conjugal transfer protein similar to TcpC which is required for efficient conjugal transfer; membrane localization is important for its function, as are oligomerization and interaction with the conjugation proteins TcpA, TcpH and TcpG

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpcC pfam12642
Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative ...
 75-299 6.02e-68

Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.


:

Pssm-ID: 463652  Cd Length: 230  Bit Score: 211.18  E-value: 6.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632  75 FVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSsTVTNVIVWHIEQSGTDTFSATYEVDQQIKE 154
Cdd:pfam12642   1 FAKNFAKEYLTWSNSQEAIEQRIERLAPYLTKGLDDLSLDDGRADIPTR-TVTSVRLLEVEKAGDGYYLVTYLVDYEITE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632 155 GEQTRNVKATYTVKVhVDADGDMVIVQNPTL----APAIEKSDYEPKTPEADASVDADTVNDATTFLETFFKLYPTATEK 230
Cdd:pfam12642  80 GEGKKNVTRYLRVPV-TDKGGGLVILGLPTLvaipATDISKKGYEPKQDPDDEDVDTEETQEIEEFLNTFFKLYATGDKE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124955632 231 ELAYYVTGNVIEPIGRDYLYSELVNPIFTKDGDN--VKVKVAVKFLDNQTKATQVSQYELVLHKDS-NWKIV 299
Cdd:pfam12642 159 ELTYYVKPGALLPAGVELVFVELVNPRYYKEGQNgvVLVRVTVKFKDAETKQTLTSQFTLTLTKTAgSWFIQ 230
 
Name Accession Description Interval E-value
TpcC pfam12642
Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative ...
 75-299 6.02e-68

Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.


Pssm-ID: 463652  Cd Length: 230  Bit Score: 211.18  E-value: 6.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632  75 FVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSsTVTNVIVWHIEQSGTDTFSATYEVDQQIKE 154
Cdd:pfam12642   1 FAKNFAKEYLTWSNSQEAIEQRIERLAPYLTKGLDDLSLDDGRADIPTR-TVTSVRLLEVEKAGDGYYLVTYLVDYEITE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632 155 GEQTRNVKATYTVKVhVDADGDMVIVQNPTL----APAIEKSDYEPKTPEADASVDADTVNDATTFLETFFKLYPTATEK 230
Cdd:pfam12642  80 GEGKKNVTRYLRVPV-TDKGGGLVILGLPTLvaipATDISKKGYEPKQDPDDEDVDTEETQEIEEFLNTFFKLYATGDKE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124955632 231 ELAYYVTGNVIEPIGRDYLYSELVNPIFTKDGDN--VKVKVAVKFLDNQTKATQVSQYELVLHKDS-NWKIV 299
Cdd:pfam12642 159 ELTYYVKPGALLPAGVELVFVELVNPRYYKEGQNgvVLVRVTVKFKDAETKQTLTSQFTLTLTKTAgSWFIQ 230
TcpC_N cd16386
N-terminal domain of conjugative transposon protein TcpC; This family contains the N-terminal ...
 66-188 8.14e-32

N-terminal domain of conjugative transposon protein TcpC; This family contains the N-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. N-terminal region (sometimes referred to as central domain) of TcpC is required for efficient conjugation, oligomerization and protein-protein interactions. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.


Pssm-ID: 319860  Cd Length: 123  Bit Score: 114.71  E-value: 8.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632  66 LQDTNGIENFVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSSTVTnviVWHIEQSGTDTFSAT 145
Cdd:cd16386     4 LADTPAAESFAENFAKEYFTWSNDDEAQEERAERLKKYLAEGLDEQNGDDVRSDLPTSSSVQ---LWSVEENSEAQYRVT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2124955632 146 YEVDQQIKEGEQTRNVKATYTVKVHVDaDGDMVIVQNPTLAPA 188
Cdd:cd16386    81 YKVEQKITEEEEKKEVTSYLNVPVYVD-GGSFVVVGLPYFTAV 122
 
Name Accession Description Interval E-value
TpcC pfam12642
Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative ...
 75-299 6.02e-68

Conjugative transposon protein TcpC; This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.


Pssm-ID: 463652  Cd Length: 230  Bit Score: 211.18  E-value: 6.02e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632  75 FVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSsTVTNVIVWHIEQSGTDTFSATYEVDQQIKE 154
Cdd:pfam12642   1 FAKNFAKEYLTWSNSQEAIEQRIERLAPYLTKGLDDLSLDDGRADIPTR-TVTSVRLLEVEKAGDGYYLVTYLVDYEITE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632 155 GEQTRNVKATYTVKVhVDADGDMVIVQNPTL----APAIEKSDYEPKTPEADASVDADTVNDATTFLETFFKLYPTATEK 230
Cdd:pfam12642  80 GEGKKNVTRYLRVPV-TDKGGGLVILGLPTLvaipATDISKKGYEPKQDPDDEDVDTEETQEIEEFLNTFFKLYATGDKE 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124955632 231 ELAYYVTGNVIEPIGRDYLYSELVNPIFTKDGDN--VKVKVAVKFLDNQTKATQVSQYELVLHKDS-NWKIV 299
Cdd:pfam12642 159 ELTYYVKPGALLPAGVELVFVELVNPRYYKEGQNgvVLVRVTVKFKDAETKQTLTSQFTLTLTKTAgSWFIQ 230
TcpC_N cd16386
N-terminal domain of conjugative transposon protein TcpC; This family contains the N-terminal ...
 66-188 8.14e-32

N-terminal domain of conjugative transposon protein TcpC; This family contains the N-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. N-terminal region (sometimes referred to as central domain) of TcpC is required for efficient conjugation, oligomerization and protein-protein interactions. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.


Pssm-ID: 319860  Cd Length: 123  Bit Score: 114.71  E-value: 8.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632  66 LQDTNGIENFVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSSTVTnviVWHIEQSGTDTFSAT 145
Cdd:cd16386     4 LADTPAAESFAENFAKEYFTWSNDDEAQEERAERLKKYLAEGLDEQNGDDVRSDLPTSSSVQ---LWSVEENSEAQYRVT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2124955632 146 YEVDQQIKEGEQTRNVKATYTVKVHVDaDGDMVIVQNPTLAPA 188
Cdd:cd16386    81 YKVEQKITEEEEKKEVTSYLNVPVYVD-GGSFVVVGLPYFTAV 122
TcpC_C cd16428
C-terminal domain of conjugative transposon protein TcpC; This family contains the C-terminal ...
 205-299 1.51e-29

C-terminal domain of conjugative transposon protein TcpC; This family contains the C-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. C-terminal domain is critical for interactions with these other conjugation proteins. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.


Pssm-ID: 319759  Cd Length: 97  Bit Score: 108.08  E-value: 1.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124955632 205 VDADTVNDATTFLETFFKLYPTATEKELAYYVTGNVIEPIGRDYLYSELVNPIFTKDGDNVKVKVAVKFLDNQTKATQVS 284
Cdd:cd16428     1 VDAEEKEEIEEFLETFFKAYATGSEEELSYYMKDKDPEGLNGDYTFVSLDNPVYKGKGDGYIVTVTVTFKDKDTGIEQTE 80

                          90
                  ....*....|....*.
gi 2124955632 285 QYELVLHK-DSNWKIV 299
Cdd:cd16428    81 QYTLTLVKkDGRWYVK 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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