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Conserved domains on  [gi|2124871198|ref|WP_227096759|]
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MULTISPECIES: bifunctional lytic transglycosylase/C40 family peptidase [Lachnospiraceae]

Protein Classification

bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 13013941)

bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Gene Ontology:  GO:0008233|GO:0016787|GO:0006508
MEROPS:  C40
PubMed:  12620121|11517925|8765311|7479697

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CwlT-like cd16891
CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall ...
 52-202 1.07e-77

CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381612 [Multi-domain]  Cd Length: 151  Bit Score: 234.42  E-value: 1.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  52 HQPTVEKYAKEYGISDYVNYLLAIMQVESGGTATDVMQSSESMGLPPNS-LSTEESIKQGCKYFSELLKSAEAKGCDIDT 130
Cdd:cd16891     1 YRPLVEKEAKKYGIPEYVPLILAIIMQESGGKGPDIMQSSESAGLPPNTiTDPEESIEQGVKYFADVLKKAKGKGVDIWT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124871198 131 VVQAYNYGGGFIDYVAKHGKKYTFELAVSFAKDKSGGVKVTYKNeISIKENGGWRYKYGNMFYVRLVNQYLA 202
Cdd:cd16891    81 AVQAYNFGGGYIDYVAKNGGKYTLELAKAYSREVVAPSLGNYTG-SALYNGGYLYYNYGDFFYVELVMRYLA 151
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
199-330 3.11e-47

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 158.71  E-value: 3.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 199 QYLAVPSFSDATAQAIFKEALKYQGWKYVFGGSNPNtSFDCSGLTSWCYGKAGISLPRTAQAQYDATQHIPLSQAKAGDL 278
Cdd:COG0791    88 SAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDL 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2124871198 279 VFFhstYNSGTYVTHVGIYAGNNRMYHA---GDPIGYADLTSPYWQKHLIGAGRV 330
Cdd:COG0791   167 VFF---RTGGGGISHVGIYLGNGKFIHAsssGKGVRISSLDSPYWKSRYVGARRV 218
 
Name Accession Description Interval E-value
CwlT-like cd16891
CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall ...
 52-202 1.07e-77

CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381612 [Multi-domain]  Cd Length: 151  Bit Score: 234.42  E-value: 1.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  52 HQPTVEKYAKEYGISDYVNYLLAIMQVESGGTATDVMQSSESMGLPPNS-LSTEESIKQGCKYFSELLKSAEAKGCDIDT 130
Cdd:cd16891     1 YRPLVEKEAKKYGIPEYVPLILAIIMQESGGKGPDIMQSSESAGLPPNTiTDPEESIEQGVKYFADVLKKAKGKGVDIWT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124871198 131 VVQAYNYGGGFIDYVAKHGKKYTFELAVSFAKDKSGGVKVTYKNeISIKENGGWRYKYGNMFYVRLVNQYLA 202
Cdd:cd16891    81 AVQAYNFGGGYIDYVAKNGGKYTLELAKAYSREVVAPSLGNYTG-SALYNGGYLYYNYGDFFYVELVMRYLA 151
Lysozyme_like pfam13702
Lysozyme-like;
46-201 1.04e-76

Lysozyme-like;


Pssm-ID: 433415 [Multi-domain]  Cd Length: 165  Bit Score: 232.62  E-value: 1.04e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  46 SEEVLKHQPTVEKYAKEYGISDYVNYLLAIMQVESGGTATDVMQSSESMGLPPNSL-STEESIKQGCKYFSELLKSAEAK 124
Cdd:pfam13702   1 SEEVLAYQPMVEKEAKEQGIPEYVPLILAIIYQESKGKGGDVMQSSESLGGPPNTItDPEESIKQGVKYLAENLEKAKKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 125 GCDIDTVVQAYNYGGGFIDYVAKHGKKYTFELAVSFAKDKS-------GGVKVTYKNEISIKENGGWRYK-YGNMFYVRL 196
Cdd:pfam13702  81 GVDLWTAVQAYNFGKGYIDYVAENGGKHTEELAKQYSKEVVapslgntTGEKYTYSNPVAIEYNGGWLYAnYGNIFYAEH 160


                  ....*
gi 2124871198 197 VNQYL 201
Cdd:pfam13702 161 VKQYY 165
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
199-330 3.11e-47

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 158.71  E-value: 3.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 199 QYLAVPSFSDATAQAIFKEALKYQGWKYVFGGSNPNtSFDCSGLTSWCYGKAGISLPRTAQAQYDATQHIPLSQAKAGDL 278
Cdd:COG0791    88 SAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDL 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2124871198 279 VFFhstYNSGTYVTHVGIYAGNNRMYHA---GDPIGYADLTSPYWQKHLIGAGRV 330
Cdd:COG0791   167 VFF---RTGGGGISHVGIYLGNGKFIHAsssGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 223-329 2.63e-37

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 129.33  E-value: 2.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 223 GWKYVFGGSNPnTSFDCSGLTSWCYGKAGISLPRTAQAQYDATQH-IPLSQAKAGDLVFFHSTYNSGtyvtHVGIYAGNN 301
Cdd:pfam00877   1 GVPYRWGGGSP-SGFDCSGLVRYAFAKVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKGIS----HVGIYLGNG 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 2124871198 302 RMYHA--GDPIGYADLTSPYWQKHLIGAGR 329
Cdd:pfam00877  76 QMLHAstGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
207-330 9.89e-36

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 134.93  E-value: 9.89e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 207 SDATAQAIFKEALKYQGWKYVFGGSNPnTSFDCSGLTSWCYGKAGISLPRTAQAQYDATQHIPLSQAKAGDLVFFhsTYN 286
Cdd:PRK13914  362 SNSSASAIIAEAQKHLGKAYSWGGNGP-TTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFF--DYG 438

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2124871198 287 SGtyVTHVGIYAGNNRMYHAGDP-IGYADLTSPYWQKHLIGAGRV 330
Cdd:PRK13914  439 SG--ISHVGIYVGNGQMINAQDNgVKYDNIHGSGWGKYLVGFGRV 481
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 50-152 2.19e-06

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 48.07  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  50 LKHQPTVEKYAKEYGISDYvnYLLAIMQVESG-------------------GTATDVmqsSESMGLPPNSLST---EESI 107
Cdd:COG0741   101 LPYLPLIEEAAKKYGVDPA--LVLALIRQESAfnpnavspagarglmqlmpATARRL---GLKLGLGPSPDDLfdpETNI 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2124871198 108 KQGCKYFSELLKsaEAKGcDIDTVVQAYNYGGGfidYVAKHGKKY 152
Cdd:COG0741   176 RAGAAYLRELLD--RFDG-DLVLALAAYNAGPG---RVRRWLRRN 214
 
Name Accession Description Interval E-value
CwlT-like cd16891
CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall ...
 52-202 1.07e-77

CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381612 [Multi-domain]  Cd Length: 151  Bit Score: 234.42  E-value: 1.07e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  52 HQPTVEKYAKEYGISDYVNYLLAIMQVESGGTATDVMQSSESMGLPPNS-LSTEESIKQGCKYFSELLKSAEAKGCDIDT 130
Cdd:cd16891     1 YRPLVEKEAKKYGIPEYVPLILAIIMQESGGKGPDIMQSSESAGLPPNTiTDPEESIEQGVKYFADVLKKAKGKGVDIWT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2124871198 131 VVQAYNYGGGFIDYVAKHGKKYTFELAVSFAKDKSGGVKVTYKNeISIKENGGWRYKYGNMFYVRLVNQYLA 202
Cdd:cd16891    81 AVQAYNFGGGYIDYVAKNGGKYTLELAKAYSREVVAPSLGNYTG-SALYNGGYLYYNYGDFFYVELVMRYLA 151
Lysozyme_like pfam13702
Lysozyme-like;
46-201 1.04e-76

Lysozyme-like;


Pssm-ID: 433415 [Multi-domain]  Cd Length: 165  Bit Score: 232.62  E-value: 1.04e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  46 SEEVLKHQPTVEKYAKEYGISDYVNYLLAIMQVESGGTATDVMQSSESMGLPPNSL-STEESIKQGCKYFSELLKSAEAK 124
Cdd:pfam13702   1 SEEVLAYQPMVEKEAKEQGIPEYVPLILAIIYQESKGKGGDVMQSSESLGGPPNTItDPEESIKQGVKYLAENLEKAKKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 125 GCDIDTVVQAYNYGGGFIDYVAKHGKKYTFELAVSFAKDKS-------GGVKVTYKNEISIKENGGWRYK-YGNMFYVRL 196
Cdd:pfam13702  81 GVDLWTAVQAYNFGKGYIDYVAENGGKHTEELAKQYSKEVVapslgntTGEKYTYSNPVAIEYNGGWLYAnYGNIFYAEH 160


                  ....*
gi 2124871198 197 VNQYL 201
Cdd:pfam13702 161 VKQYY 165
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
199-330 3.11e-47

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 158.71  E-value: 3.11e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 199 QYLAVPSFSDATAQAIFKEALKYQGWKYVFGGSNPNtSFDCSGLTSWCYGKAGISLPRTAQAQYDATQHIPLSQAKAGDL 278
Cdd:COG0791    88 SAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPS-GFDCSGLVQYVYRQAGISLPRTSADQAAAGTPVSRSELQPGDL 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2124871198 279 VFFhstYNSGTYVTHVGIYAGNNRMYHA---GDPIGYADLTSPYWQKHLIGAGRV 330
Cdd:COG0791   167 VFF---RTGGGGISHVGIYLGNGKFIHAsssGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 223-329 2.63e-37

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 129.33  E-value: 2.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 223 GWKYVFGGSNPnTSFDCSGLTSWCYGKAGISLPRTAQAQYDATQH-IPLSQAKAGDLVFFHSTYNSGtyvtHVGIYAGNN 301
Cdd:pfam00877   1 GVPYRWGGGSP-SGFDCSGLVRYAFAKVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKGIS----HVGIYLGNG 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 2124871198 302 RMYHA--GDPIGYADLTSPYWQKHLIGAGR 329
Cdd:pfam00877  76 QMLHAstGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
207-330 9.89e-36

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 134.93  E-value: 9.89e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 207 SDATAQAIFKEALKYQGWKYVFGGSNPnTSFDCSGLTSWCYGKAGISLPRTAQAQYDATQHIPLSQAKAGDLVFFhsTYN 286
Cdd:PRK13914  362 SNSSASAIIAEAQKHLGKAYSWGGNGP-TTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFF--DYG 438

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2124871198 287 SGtyVTHVGIYAGNNRMYHAGDP-IGYADLTSPYWQKHLIGAGRV 330
Cdd:PRK13914  439 SG--ISHVGIYVGNGQMINAQDNgVKYDNIHGSGWGKYLVGFGRV 481
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
220-333 3.16e-16

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 75.57  E-value: 3.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198 220 KYQGWK---YVFGGSNpNTSFDCSGLTSWCYGKA-GISLPRTAQAQYDATQHIPLSQAKAGDLVFFHstynSGTYVTHVG 295
Cdd:PRK10838   73 QYADWKgvrYRLGGST-KKGIDCSAFVQRTFREQfGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFR----AGSTGRHVG 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2124871198 296 IYAGNNRMYHAGDPIGY--ADLTSPYWQKHLIGAGRVKSK 333
Cdd:PRK10838  148 IYIGNNQFVHASTSSGViiSSMNEPYWKKRYNEARRVLSR 187
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 72-152 4.00e-08

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 50.67  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  72 LLAIMQVESGG--------TATDVMQSSESMG------LPPNSLSTEESIKQGCKYFSELLKsaEAKGcDIDTVVQAYNY 137
Cdd:cd00254     4 VLAVIRVESGFnpravspaGARGLMQLMPGTArdlgrrGVDDLFDPEENIRAGARYLRELLD--RFGG-DLELALAAYNA 80

                          90
                  ....*....|....*
gi 2124871198 138 GGGfidYVAKHGKKY 152
Cdd:cd00254    81 GPG---AVDRWGGGE 92
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 50-143 8.74e-07

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 47.89  E-value: 8.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  50 LKHQPTVEKYAKEYGISDYVnyLLAIMQVESG---------GtATDVMQ--------SSESMGLPPNSLST----EESIK 108
Cdd:cd16896     2 LKYREYIEKYAKEYGVDPLL--VAAVIKVESNfnpnavsskG-AIGLMQimpetaewIAEKLGLEDFSEDDlydpETNIR 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2124871198 109 QGCKYFSELLKsaEAKGcDIDTVVQAYNYGGGFID 143
Cdd:cd16896    79 LGTWYLSYLLK--EFDG-NLVLALAAYNAGPGNVD 110
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 50-152 2.19e-06

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 48.07  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  50 LKHQPTVEKYAKEYGISDYvnYLLAIMQVESG-------------------GTATDVmqsSESMGLPPNSLST---EESI 107
Cdd:COG0741   101 LPYLPLIEEAAKKYGVDPA--LVLALIRQESAfnpnavspagarglmqlmpATARRL---GLKLGLGPSPDDLfdpETNI 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2124871198 108 KQGCKYFSELLKsaEAKGcDIDTVVQAYNYGGGfidYVAKHGKKY 152
Cdd:COG0741   176 RAGAAYLRELLD--RFDG-DLVLALAAYNAGPG---RVRRWLRRN 214
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 58-142 4.15e-04

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 39.21  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  58 KYAKEYGISdyVNYLLAIMQVESGG--------TATDVMQ----SSESMGLPPNS-----LSTEESIKQGCKYFSELLKS 120
Cdd:pfam01464   3 KAAQKYGVD--PSLLLAIAQQESGFnpkavsksGAVGLMQimpsTAKRLGLRVNPgvddlFDPEKNIKAGTKYLKELYKQ 80

                          90       100
                  ....*....|....*....|..
gi 2124871198 121 AeakGCDIDTVVQAYNYGGGFI 142
Cdd:pfam01464  81 Y---GGDLWLALAAYNAGPGRV 99
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 51-140 1.94e-03

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 39.66  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2124871198  51 KHQPTVEKYAKEYGIsDYVNyLLAIMQVESG---------GtATDVMQ----SSESMGLpPNSLSTEESIKQGCKYFSEL 117
Cdd:COG4623   263 PYDPLFEKYAEEYGL-DWRL-LAALAYQESHwnprarsptG-ARGLMQlmpaTAKELGV-DDRLDPEQSIRAGAKYLRWL 338

                          90       100
                  ....*....|....*....|....*.
gi 2124871198 118 LK--SAEAKGCD-IDTVVQAYNYGGG 140
Cdd:COG4623   339 YDrfPEAIDEPDrWWFALAAYNAGPG 364
yfaT COG3234
Uncharacterized conserved protein YfaT, DUF1175 family [Function unknown];
269-311 5.66e-03

Uncharacterized conserved protein YfaT, DUF1175 family [Function unknown];


Pssm-ID: 442466  Cd Length: 231  Bit Score: 37.77  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2124871198 269 PLSQAKAGDLVFFHSTYNSGTYvtHVGIYAGNNRMYHAGdPIG 311
Cdd:COG3234   151 DLNQALPGDLLFFDHPEDDMPY--HLMIYMGDGIVYHTG-PVG 190
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 54-82 8.69e-03

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 36.38  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|....*....
gi 2124871198  54 PTVEKYAKEYGISdyVNYLLAIMQVESGG 82
Cdd:cd16893     1 PIVEKYAKKYGVD--PALILAIIETESSF 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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