BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DDSKNVLDLHHVTVTGFIP 84
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2119492405  85 LLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405 351 PTLQSTSSTNTHADDEDRTE-RPSPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDR--CGKKFTRAYSLKMH 427
Cdd:COG5048     3 LTSSQSSSSNNSVLSSTPKStLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRH 82

                  ....
gi 2119492405 428 RLKH 431
Cdd:COG5048    83 LRTH 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DDSKNVLDLHHVTVTGFIP 84
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2119492405  85 LLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405   32 DITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYM 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 2119492405  112 QMFSVASTCSEFMKSSI 128
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 2119492405 395 NLKQHMLIHSGIKPFQCDRCGKKFTR 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 2119492405 381 FQCPTCGVRFTRIQNLKQHMLIH 403
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DDSKNVLDLHHVTVTGFIP 84
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2119492405  85 LLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYTA 92
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2119492405  93 TLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18255    81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAM 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  11 PSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVgqaedDSKNVLDLHHVTVTGFIPLLEYAY 90
Cdd:cd18206     3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV-----DQKDVVHLDISNAAGLGQVLEFMY 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2119492405  91 TATLSINTENIIDVLAAASYMQMFSVASTCSEF 123
Cdd:cd18206    78 TAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYT 91
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2119492405  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18242    83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLES 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  11 PSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAY 90
Cdd:cd18326     6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAY 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2119492405  91 TATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18326    86 TATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  31 CDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSknVLDL-HHVTVTGFIPLLEYAYTATLSINTENIIDVLAAAS 109
Cdd:cd18955     2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDL--VITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAE 79

                          90
                  ....*....|....*
gi 2119492405 110 YMQMFSVASTCSEFM 124
Cdd:cd18955    80 FLGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYTA 92
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2119492405  93 TLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18256    83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  10 SPSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYA 89
Cdd:cd18261     8 SKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFA 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2119492405  90 YTATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18261    88 YTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405   5 TFTHSSPSHSQEMLGKLNMLR-NDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSK-NVLDLHHVTVTGF 82
Cdd:cd18207     1 SYTYQVSQHSADMLHNLNQQRkSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2119492405  83 IPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSS 127
Cdd:cd18207    81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  21 LNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAeddskNVLDLHHVTVTGFIP-----LLEYAYTATLS 95
Cdd:cd18240     8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGW-----NETEKKVYKIPGVSPemmelIIEYAYTRTVP 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2119492405  96 INTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18240    83 ITAENVEELLPAADQFNIMGIVKACCDFLED 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  16 EMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2119492405  96 INTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18238    81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKD 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTklvgQAEDDSKNV--LDLHHVTVTGFIPLLEYAY 90
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGA----QYKDTEDNIvfLDQSQVSADGFQKLLEFIY 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2119492405  91 TATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18217    77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKCKIKM 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTK--LVGQAEDDSKNVLDLHHVTVTGFIPLLEYA 89
Cdd:cd18201     3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLycFTNKESCDQTTVTHLDVVAVQGFSVILDFM 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2119492405  90 YTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18201    83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQ--AEDDSKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2119492405  95 SINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSkNVLDL-HHVTVTGFIPLLEYAYT 91
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGV-SVLTLpSGLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2119492405  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  11 PSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAY 90
Cdd:cd18235     2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2119492405  91 TATLSINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18235    82 TAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  11 PSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRtkLVGQAEDDSKNVLDLHH--VTVTGFIPLLEY 88
Cdd:cd18325     4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH--LFYRDQLDKRDIVHLNSdiVTAPAFSLLLEF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2119492405  89 AYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSIL 129
Cdd:cd18325    82 MYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKEL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSK-NVLDLHHVTVTGFIPLLEYAYT 91
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRpSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2119492405  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  21 LNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQ-AEDDSKnvldlhHVTVTGFIP-----LLEYAYTATL 94
Cdd:cd18247    10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmVESKQD------EITMQGIEPsaleaLINFAYSGRI 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2119492405  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18247    84 AIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  12 SHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHV-TVTGFIPLLEYAY 90
Cdd:cd18329     3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVY 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2119492405  91 TATLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18329    83 SGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNVLDLHHVTVTGFIPLLEYAYTA 92
Cdd:cd18237     4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTA 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2119492405  93 TLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18237    84 RISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  13 HSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEdDSKNVLDL-HHVTVTGFIPLLEYAYT 91
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLK-NNVSVINLdPEIEPEGFRILLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2119492405  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEF 123
Cdd:cd18215    81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2119492405  11 PSHSQEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDDSKNV--LDLHHVTVTGFIPLLEY 88
Cdd:cd18196     2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMiqLDSEVVTAEAFAALIDM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2119492405  89 AYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILWNTP 133
Cdd:cd18196    82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSP 126