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Conserved domains on  [gi|2116730773|ref|XP_044233430|]
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opsin-5 isoform X1 [Thunnus albacares]

Protein Classification

opsin-5 family protein( domain architecture ID 11606773)

opsin-5 family protein belongs to the type 2 opsin family of the class A G-protein coupled receptors (GPCRs), such as Human opsin-5 (also known as neuropsin) which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
71-343 3.44e-144

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


:

Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 410.13  E-value: 3.44e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15074    10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSIN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd15074    90 TLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGASASVGGMSYIIS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15074   170 IFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDS 249
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIYQVVDLKNSC 343
Cdd:cd15074   250 VPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
 
Name Accession Description Interval E-value
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
71-343 3.44e-144

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 410.13  E-value: 3.44e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15074    10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSIN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd15074    90 TLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGASASVGGMSYIIS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15074   170 IFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDS 249
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIYQVVDLKNSC 343
Cdd:cd15074   250 VPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
78-334 3.41e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 142.82  E-value: 3.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLI-GWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFF 234
Cdd:pfam00001  81 IDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 clILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:pfam00001 161 --LLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRR-----KALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 2116730773 315 VSVVPTL---LAKSSAMYNPIIY 334
Cdd:pfam00001 234 LDKALSVtlwLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
80-354 3.60e-07

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 51.32  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  80 GYVIYMTIKRKTKLKPPELM-TVNLAIFDFgISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGCGSLITM---TMV 155
Cdd:PHA03087   57 GNIIVIYVLTKTKIKTPMDIyLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKI---VSGLYYIGFYNSMnfiTVM 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGTWLK--RHHAFLCLVfVWVYAAFwATMPLIGWGNYAPE-------PFGTSCTLDWWLAqaslsgQT 226
Cdd:PHA03087  133 SVDRYIAIVHPVKSNKINtvKYGYIVSLV-IWIISII-ETTPILFVYTTKKDhetliccMFYNNKTMNWKLF------IN 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFclILPTGIIVFSYVMIIFKVKsstkevshfdaRINNSHNlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF- 305
Cdd:PHA03087  205 FEINIIGM--LIPLTILLYCYSKILITLK-----------GINKSKK-NKKAIKLVLIIVILFVIFWLPFNVSVFVYSLh 270
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 306 ------GEPDSVPIPVSV-VPTLLAKSSAMYNPIIYQVVDLKNSCAKSSCFKVLKK 354
Cdd:PHA03087  271 ilhfksGCKAVKYIQYALhVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFT 326
 
Name Accession Description Interval E-value
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
71-343 3.44e-144

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 410.13  E-value: 3.44e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15074    10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSIN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd15074    90 TLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGASASVGGMSYIIS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15074   170 IFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDS 249
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIYQVVDLKNSC 343
Cdd:cd15074   250 VPILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
71-338 1.18e-93

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 281.79  E-value: 1.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd14969    10 IGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSIS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLaqASLSGQTFVMA 230
Cdd:cd14969    90 TLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYS--KDPNSLSYIVS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSH--FDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP 308
Cdd:cd14969   168 LFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARrkNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGE 247
                         250       260       270
                  ....*....|....*....|....*....|
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd14969   248 STIPPLLATIPALFAKSSTIYNPIIYVFMN 277
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
71-334 3.06e-68

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 217.06  E-value: 3.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15079    10 LGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIW 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPL-IGWGNYAPEPFGTSCTLDWwLAQaSLSGQTFVM 229
Cdd:cd15079    89 TNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWALLPLlFGWGRYVPEGFLTSCSFDY-LTR-DWNTRSFVA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARIN----------NSHNLEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15079   167 TIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAKKMNvvslrsnadaNKQSAEIRIAKVALTNVFLWFIAWTPYAVV 246
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 300 SVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15079   247 ALIGAFGNQSLLTPLVSMIPALFAKTAACYNPIVY 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
71-340 1.14e-66

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 212.67  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15073    10 AGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSgqTFVMA 230
Cdd:cd15073    90 LLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSSFV--SYTMS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15073   168 VIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTD--QNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKK 245
                         250       260       270
                  ....*....|....*....|....*....|
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15073   246 IPPWMAIIPPLFAKSSTFYNPCIYVIANKK 275
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
71-334 1.87e-66

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 212.58  E-value: 1.87e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15083    10 IGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSIN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRH-HAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDwWLAQASLSgQTFVM 229
Cdd:cd15083    90 TLAAIAVDRYLVITRPMKASVRISHrRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFD-YLSRDDAN-RSYVI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSH--------NLEMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15083   168 CLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSElsspkarrQAEVKTAKIALLLVLLFCLAWTPYAVVAL 247
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 302 VSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15083   248 IGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIY 280
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
71-334 2.99e-66

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 211.80  E-value: 2.99e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGIS-VTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15337    10 VGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSaVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwLAQaSLSGQTFV 228
Cdd:cd15337    90 TTLAAISIDRYLVIAKpLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDY-LSR-DLNNRLFI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 229 MAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARIN--------NSHNLEMKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd15337   168 LGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQTAKSGMgkdtekndARKKAEIRIAKVAIILISLFLLSWTPYAVVA 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2116730773 301 VVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15337   248 LLGQFGPAYWITPYVSELPVMFAKASAIYNPIIY 281
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
69-337 2.00e-63

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 204.57  E-value: 2.00e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd15336     8 LIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlAQASLSGQTF 227
Cdd:cd15336    88 MITLLAISLDRYLVITKpLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDY--MTFTPSVRAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNL-------EMKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd15336   166 TMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRKEKAKqyqrmknEWKMAKIAFVVILLFVLSWSPYACVA 245
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2116730773 301 VVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15336   246 LIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAIT 282
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
71-334 1.59e-48

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 165.54  E-value: 1.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd00637     8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASIL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYaPEPFGTSCTLDWWLAQASlsgQTFVM 229
Cdd:cd00637    88 TLTAISVDRYLAIVHpLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVY-DYGGYCCCCLCWPDLTLS---KAYTI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSSTKEV--SHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF-G 306
Cdd:cd00637   164 FLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIrsSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFgP 243
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 307 EPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd00637   244 DPSPLPRILYFLALLLAYLNSAINPIIY 271
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
71-334 2.59e-48

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 164.91  E-value: 2.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15086    10 ILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASlsGQTFVMA 230
Cdd:cd15086    90 SLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRSAN--SISYIIC 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKeVSHFDARINNSHNLEMKLTkvaMLICagFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15086   168 LFIFCLLLPFLVMVYCYGRLLYAIKQVGK-INKSTARKREQHVLLMVVT---MVIC--YLLCWLPYGVMALLATFGKPGL 241
                         250       260
                  ....*....|....*....|....
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15086   242 VTPVASIVPSILAKSSTVVNPIIY 265
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
79-334 1.38e-43

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 152.13  E-value: 1.38e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGkPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLD 158
Cdd:cd15072    18 NGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNA-LVAASSSLLRRWPYGSEGCQAHGFQGFFTALASICSSAAIAWD 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 159 RYLKICHLRYGTWlkrHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlAQASLSGQTFVMAILFFCLIL 238
Cdd:cd15072    97 RYHHYCTRSKLQW---STAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDY--SKGDRNYVSYLFTMAFFNFIL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 239 PTGIIVFSYVMIIFKVKSstkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVV 318
Cdd:cd15072   172 PLFILLTSYSSIEQKLKK------------------EGHLRFNTGLPLLTLLICWGPYAILALYAAITDVTSISPKLRMV 233
                         250
                  ....*....|....*.
gi 2116730773 319 PTLLAKSSAMYNPIIY 334
Cdd:cd15072   234 PALLAKTSPTINAILY 249
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
66-334 6.82e-42

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 148.05  E-value: 6.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFG 145
Cdd:cd15078     5 LLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKICHLRY--GTWLKRhhaflCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlAQASLS 223
Cdd:cd15078    85 IVSIMTLTVLAYERYIRVVHAKVvnFSWSWR-----AITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDW--KSKDPN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFCLILPTGIIVFSYVMIIFKVK--SSTKEVSHFdaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15078   158 DTSFVLLFFLGCLVVPLGIMAYCYGHILYEIRmlRSVEDLQTF--QVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSL 235
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 302 VSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15078   236 LVTSGYSKLVTPTIAIIPSLFAKSSTAYNPVIY 268
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
73-334 7.97e-41

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 145.38  E-value: 7.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15085    12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlAQASLSGQTFVMAIL 232
Cdd:cd15085    92 TLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCSIGW--EERSWSNYSYLILYF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLIcaGFLIAWIPYAVVSVVSAFGEPDSVP 312
Cdd:cd15085   170 LMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVI--AFLICWLPYTVFALIVVVNPELSIS 247
                         250       260
                  ....*....|....*....|..
gi 2116730773 313 IPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15085   248 PLAATMPTYFAKTSPVYNPIIY 269
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
78-334 3.41e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 142.82  E-value: 3.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLI-GWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFF 234
Cdd:pfam00001  81 IDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLfGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 clILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:pfam00001 161 --LLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRR-----KALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 2116730773 315 VSVVPTL---LAKSSAMYNPIIY 334
Cdd:pfam00001 234 LDKALSVtlwLAYVNSCLNPIIY 256
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
74-334 6.83e-40

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 143.40  E-value: 6.83e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  74 MSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMT 153
Cdd:cd15082    26 LSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLA 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 154 MVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWlaQASLSGQTFVMAILF 233
Cdd:cd15082   106 VLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWY--SGNMHDHTYIITFFT 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FCLILPTGIIVFSYVMIIFKVksstKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPI 313
Cdd:cd15082   184 TCFILPLGVIFVSYGKLLQKL----RKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHPTIHLDP 259
                         250       260
                  ....*....|....*....|.
gi 2116730773 314 PVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15082   260 RLAAIPAFFSKTAAVYNPIIY 280
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
79-334 1.11e-37

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 137.22  E-value: 1.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLD 158
Cdd:cd15075    18 NATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFGIAALCTVAVIAVD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 159 RYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWlaQASLSGQTFVMAILFFCLIL 238
Cdd:cd15075    98 RLFVVCKPLGTLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWY--SRDPVNVSYILCYFSFCFAI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 239 PTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVV 318
Cdd:cd15075   176 PFAIILVSYGYLLWTLRQVAKLGVAEGGSTAKA---EVQVARMVVVMVMAFLLCWLPYAAFALTVVSKPDVYINPLIATV 252
                         250
                  ....*....|....*.
gi 2116730773 319 PTLLAKSSAMYNPIIY 334
Cdd:cd15075   253 PMYLAKSSTVYNPIIY 268
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
63-334 2.40e-34

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 128.44  E-value: 2.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  63 GVRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGF 142
Cdd:cd15084    12 TVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCGSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQAsl 222
Cdd:cd15084    92 LTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCGPNWYTGGT-- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 223 SGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSstkeVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15084   170 NNNSYILALFVTCFALPLSTIIFSYSNLLLTLRA----VAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAMV 245
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 303 SAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15084   246 VATNKDVVIQPTLASLPSYFSKTATVYNPIIY 277
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
66-334 6.37e-34

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 126.52  E-value: 6.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIyMTIKRKTKL-KPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFF 144
Cdd:cd14967     4 VFLSLIILVTVFGNLLVI-LAVYRNRRLrTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 145 GCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlaqaslS 223
Cdd:cd14967    83 CTASILNLCAISLDRYLAITRpLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFT-------P 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFCLILPTGIIVFSYVMiIFKVksstkevshfdARinnshnLEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd14967   156 NKIYVLVSSVISFFIPLLIMIVLYAR-IFRV-----------AR------RELKAAKTLAIIVGAFLLCWLPFFIIYLVS 217
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2116730773 304 AFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14967   218 AFCPPDCVPPILYAVFFWLGYLNSALNPIIY 248
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
79-334 2.85e-29

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 114.54  E-value: 2.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLD 158
Cdd:cd15077    18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSLAVVAFE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 159 RYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFCLIL 238
Cdd:cd15077    98 RFLVICKPLGNFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLQCSCGPDWYTTNNKWNNESYVMFLFCFCFGV 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 239 PTGIIVFSYVMIIFKVKSSTKEvshfDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVV 318
Cdd:cd15077   178 PLSIIVFSYGRLLLTLRAVAKQ----QEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNRGEPFDLRLASI 253
                         250
                  ....*....|....*.
gi 2116730773 319 PTLLAKSSAMYNPIIY 334
Cdd:cd15077   254 PSVFSKASTVYNPVIY 269
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
71-334 2.76e-28

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 111.93  E-value: 2.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGCG--- 147
Cdd:cd15203    10 IIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKL---VPSLQGVSifv 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRhHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPF------GTSCTLDWWLAQAS 221
Cdd:cd15203    87 STLTLTAIAIDRYQLIVYPTRPRMSKR-HALLIIALIWILSLL-LSLPLAIFQELSDVPIeilpycGYFCTESWPSSSSR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMAILFfclILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVA--MLIC--AGFLIAWIPYA 297
Cdd:cd15203   165 LIYTISVLVLQF---VIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELRRKRRTnrLLIAmvVVFAVCWLPLN 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 298 VVSVVSAFGEPDSVPIPVSVVPTLLAK----SSAMYNPIIY 334
Cdd:cd15203   242 LFNLLRDFEPLPQIDGRHFYLIFLICHliamSSACVNPLLY 282
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
79-334 9.47e-28

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 110.31  E-value: 9.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLD 158
Cdd:cd15080    18 NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 159 RYLKIC----HLRYGTwlkrHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFF 234
Cdd:cd15080    98 RYVVVCkpmsNFRFGE----NHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYVMIIFKVKSSTKEvshfDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:cd15080   174 HFTIPLIVIFFCYGRLVCTVKEAAAQ----QQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPI 249
                         250       260
                  ....*....|....*....|
gi 2116730773 315 VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15080   250 FMTIPAFFAKSSAVYNPVIY 269
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
71-334 1.47e-25

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 104.60  E-value: 1.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15081    22 VVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLW 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd15081   102 SLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMIV 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDArinnSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15081   182 LMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESES----TQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYA 257
                         250       260
                  ....*....|....*....|....
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15081   258 FHPLAAALPAYFAKSATIYNPIIY 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
71-338 2.58e-24

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 100.83  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKP-PELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd14970    10 VCVVGLTGNSLVIYV-ILRYSKMKTvTNIYILNLAVAD-ELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGT-SCTLDWwLAQASLSGQTF 227
Cdd:cd14970    88 FCLTVMSVDRYLAVVHpVKSLRFRTPRKAKLVSLCVWA-LSLVLGLPVIIFARTLQEEGGTiSCNLQW-PDPPDYWGRVF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd14970   166 TIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARR---KVTRLVLVVVAVFVVCWLPFHVFQIVRLLID 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 308 PDSVPIPVSV--VPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd14970   243 PPETLTVVGVflFCIALSYANSCLNPILYAFLD 275
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
73-334 4.08e-24

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 100.75  E-value: 4.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFG---CGSL 149
Cdd:cd14993    12 LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA---VPYLQGvsvSASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLI----GWGNYAPEPFGTS---CTLDWWLAQAS 221
Cdd:cd14993    89 LTLVAISIDRYLAICYpLKARRVSTKRRARIIIVAIWVIAII-IMLPLLvvyeLEEIISSEPGTITiyiCTEDWPSPELR 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 lsgQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVA-MLIC--AGFLIAWIPYAV 298
Cdd:cd14993   168 ---KAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILRSKKKVArMLIVvvVLFALSWLPYYV 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 299 VSVVSAFGEPDSVPIPVSV-----VPTLLAKSSAMYNPIIY 334
Cdd:cd14993   245 LSILLDFGPLSSEESDENFllilpFAQLLGYSNSAINPIIY 285
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
79-334 1.93e-23

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 98.35  E-value: 1.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLD 158
Cdd:cd15076    18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 159 RYLKIC----HLRYGTwlkrHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFF 234
Cdd:cd15076    98 RYIVICkpfgNFRFGS----KHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIF 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYVMIIfkvkSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:cd15076   174 CFIVPLSIIIFSYSQLL----GALRAVAAQQQESASTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLR 249
                         250       260
                  ....*....|....*....|
gi 2116730773 315 VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15076   250 LVTIPAFFSKSSCVYNPIIY 269
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
98-334 2.39e-21

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 92.43  E-value: 2.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  98 LMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICHLRygTWLKRHHA 177
Cdd:cd15213    37 LLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQ--DKLNPHRA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 178 FLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFcliLPTGIIVFSYVMIIFKVKSs 257
Cdd:cd15213   115 KILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYTESPADRIYVVLLLVAVFF---IPFLIMLYSYFCILNTVRS- 190
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 258 tkevshFDARInnshnlemklTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15213   191 ------FKTRA----------FTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
71-334 8.18e-20

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 88.30  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKppelmTV-NLAIFDFGIS----VTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFG 145
Cdd:cd15094    10 ICIVGLVGNGLVIYV-VLRYAKMK-----TVtNLYILNLAVAdecfLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSG 224
Cdd:cd15094    84 FTSSFTLTVMSADRYLAVCHpIRSMRYRTPFIAKVVCATTWS-ISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKV-------KSSTKEVSHfdarinnshnleMKLTKVAMLICAGFLIAWIPYA 297
Cdd:cd15094   163 KAFTLYTFLLGFAIPLLLISVFYTLVILRLrtvgpknKSKEKRRSH------------RKVTRLVLTVISVYIICWLPYW 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 298 VVSVVSAFGEPDSVP----IPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15094   231 AFQVHLIFLPPGTDMpkweILMFLLLTVLSYANSMVNPLLY 271
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
77-338 5.05e-19

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 85.96  E-value: 5.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVS-SFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15193    16 LGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLT-LPFWAAStALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTGM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGTWLK-RHHAFLCLVFVWVYAAFWATMPLIgwgnYAPEPFGTSCtldwWLAQASLSGQTFVMAILFF 234
Cdd:cd15193    95 SVDRYLAVVKLLDSRPLRtRRCALITCCIIWAVSLVLGIPSLV----YRNLINESVC----VEDSSSRFFQGISLATLFL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHnlemkltKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:cd15193   167 TFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSL-------RIVFAIVTAFVLSWLPFNTLKAVRLLLELGGGVLP 239
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 315 VS---------VVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15193   240 CHttvairqglTITACLAFVNSCVNPLIYSLLD 272
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
71-308 4.47e-17

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 80.34  E-value: 4.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISV-----------TGKPFFivsSFAHRWLFGWeGCQFYGW 139
Cdd:cd15136    10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIylgllaivdakTLGEYY---NYAIDWQTGA-GCKTAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPE----PFGTSCTLD 214
Cdd:cd15136    86 LAVFSSELSVFTLTVITLERWYAITHaMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTsiclPFETETPVS 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 wwlaqaslsgQTFVMAILFFClILPTGIIVFSYVMIIFKVKSSTKEVSHFDARInnshnlemkLTKVAMLICAGFLiAWI 294
Cdd:cd15136   166 ----------KAYVIFLLLFN-GLAFLIICGCYIKIYLSVRGSGRAANSNDTRI---------AKRMALLVFTDFL-CWA 224
                         250
                  ....*....|....
gi 2116730773 295 PYAVVSVVSAFGEP 308
Cdd:cd15136   225 PIAFFGLTAAFGLP 238
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
103-334 1.42e-16

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 79.14  E-value: 1.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 103 LAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCL 181
Cdd:cd15055    42 LAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDpLLYPTKITIRRVKICI 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 182 VFVWVYAAFWATMPLIGWGNYAPEPFGTSCtldwwlaqaslSGQTFVM-------AILFFCLILPTGIIVFSYvMIIFKV 254
Cdd:cd15055   122 CLCWFVSALYSSVLLYDNLNQPGLIRYNSC-----------YGECVVVvnfiwgvVDLVLTFILPCTVMIVLY-MRIFVV 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 255 --------KSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVptLLAKSS 326
Cdd:cd15055   190 arsqaraiRSHTAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYISTPSSVFDVLIW--LGYFNS 267

                  ....*...
gi 2116730773 327 AMyNPIIY 334
Cdd:cd15055   268 CL-NPLIY 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
71-334 3.68e-16

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 78.03  E-value: 3.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKPP-ELMTVNLAIFD--FGISVtgkPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd15970    10 VCLVGLCGNSMVIYV-ILRYAKMKTAtNIYILNLAIADelLMLSV---PFLVTSTLLRHWPFGSLLCRLVLSVDAINMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGT-SCTLDW------WLAq 219
Cdd:cd15970    86 SIYCLTVLSIDRYIAVVHpIKAARYRRPTVAKMVNLGVWVFSIL-VILPIIIFSNTAPNSDGSvACNMQMpepsqrWLA- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 aslsgqTFVMAILFFCLILPTGIIVFSYVMIIFKVKsstkeVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15970   164 ------VFVVYTFLMGFLLPVIAICLCYILIIVKMR-----VVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVV 232
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 300 SVVSAFGEPDSVpiPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15970   233 QLVSVFVGQHDA--TVSQLSVILGYANSCANPILY 265
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
71-334 5.73e-16

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 76.90  E-value: 5.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15214     9 IAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASML 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlaqASLSGQTFVM 229
Cdd:cd15214    89 TLGAIAIDRYYAVLYpMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMCVAAW----HKEAGYTAFW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AIlfFCLILPTGIIVFSYvMIIFKVksstkevshfdARINnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPD 309
Cdd:cd15214   165 QV--WCALLPFVVMLVCY-GFIFRV-----------ARAN-----QCKAFITILVVLGAFVTTWGPYMVVISTEALWGKN 225
                         250       260
                  ....*....|....*....|....*
gi 2116730773 310 SVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15214   226 SVSPQLETLATWLSFTSAVCHPLIY 250
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
71-334 2.34e-15

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 75.70  E-value: 2.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgisVTGKPFFIVSSF-----------AHRWLFGWeGCQFYGW 139
Cdd:cd15137    10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADF---LMGVYLLIIASVdlyyrgvyikhDEEWRSSW-LCTFAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGnYAPEPFGTS--CtLDWWL 217
Cdd:cd15137    86 LATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIGLLLAVLPLLPWD-YFGNFYGRSgvC-LPLHI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 AQASLSGQTFVMAIL----FFCLIlptgIIVFSYVMIIFKVKSSTKEVSHfdarinNSHNLEMKLTKVAMLICAGFLIAW 293
Cdd:cd15137   164 TDERPAGWEYSVFVFlglnFLAFV----FILLSYIAMFISIRRTRKAAAS------RKSKRDMAVAKRFFLIVLTDFLCW 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2116730773 294 IPYAVVSVVSAFGepdsVPIP--------VSVVPTllakSSAMyNPIIY 334
Cdd:cd15137   234 IPIIVIGILALSG----VPIPgevyawvaVFVLPI----NSAL-NPILY 273
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
71-334 3.58e-15

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 74.97  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYM-TIKRKTKLKPPELMTVNLAIFDFGISVtgkpFFIVSSFAHRWLFGWEGCQFYGW-------AGF 142
Cdd:cd14980    10 IGILALIGNILVIIWhISSKKKKKKVPKLLIINLAIADFLMGI----YLLIIAIADQYYRGRYAQYSEEWlrsppclLAC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGC----GSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYA-------------PE 205
Cdd:cd14980    86 FLVSlsslMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILYSINQPgdnrlygyssicmPS 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 206 PFGTSCTLDWWLAQASLsgqTFVMAIlffclilptgIIVFSYVMIIFKVKSSTKevshfdARINNSHNLEMKLTKVAMLI 285
Cdd:cd14980   166 NVSNPYYRGWLIAYLLL---TFIAWI----------IICILYILIFISVRKSRK------SARRSSSKRDKRIAIRLALI 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116730773 286 CAGFLIAWIPYAVVSVVSAFGEP--DSVPIPVSVVPTLLAKSSAmyNPIIY 334
Cdd:cd14980   227 LITDLICWLPYYIVIFSGLLTSTeiDIHVLQFIAILALPLNSAI--NPYLY 275
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
71-361 3.60e-15

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 74.88  E-value: 3.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKP-PELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15971    10 VCIIGLCGNTLVIYV-ILRYAKMKTvTNIYILNLAIAD-ELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDW-WLAQASLSGQTF 227
Cdd:cd15971    88 FCLTVMSIDRYLAVVHpIKSAKWRKPRTAKMINMAVWG-VSLLVILPIMIYAGVQTKHGRSSCTIIWpGESSAWYTGFII 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFclILPTGIIVFSYVMIIFKVKSSTKEVSHfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSafge 307
Cdd:cd15971   167 YTFILGF--FVPLTIICLCYLFIIIKVKSSGIRVGS-----SKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSS---- 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2116730773 308 pdsvpIPVSVVPTLLAKSsaMYNPIIyqVVDLKNSCAKSSCFKVLKKrrHFRKS 361
Cdd:cd15971   236 -----VSVSISPTPGLKG--MFDFVV--VLSYANSCANPILYAFLSD--NFKKS 278
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
77-337 3.99e-15

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 74.80  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAHR-WLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15088    16 VGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIHQFAIDGqWYFGEVMCKIITALDANNQFTSTYILTAM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGT-SCTLDWwlaQASLSGQTFVMAILF 233
Cdd:cd15088    95 SVDRYLAVVHpIRSTKYRTRFVAKLVNVGLWA-ASFLSILPVWVYSSLIYFPDGTtFCYVSL---PSPDDLYWFTIYHFI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FCLILPTGIIVFSYVMIIFKVKSSTKEvshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVS-AFGEPDSVP 312
Cdd:cd15088   171 LGFAVPLVVITVCYILILHRLARGVAP-----GNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNlAMNRPTLAF 245
                         250       260
                  ....*....|....*....|....*
gi 2116730773 313 IPVSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15088   246 EVAYFLSICLGYANSCLNPFVYILV 270
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
71-338 4.60e-15

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 74.60  E-value: 4.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIkRKTKLKPP-ELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15091    10 VFVVGLVGNSLVMFVII-RYTKMKTAtNIYIFNLALAD-ALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH----LRYGTWLKRHHAFLClvfVWVYAAFWATMPLIGWGNYAPEPFG-TSCTLDWWLAQASLSG 224
Cdd:cd15091    88 FTLTMMSVDRYIAVCHpvkaLDFRTPLKAKIINIC---IWLLSSSVGISAIVLGGTKVREDVDsTECSLQFPDDDYSWWD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSstkeVSHFDARINNSHNLEmKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15091   165 TFMKICVFIFAFVIPVLIIIVCYTLMILRLKS----VRLLSGSREKDRNLR-RITRLVLVVVAVFVVCWTPIHIFILVEA 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 305 FGepdSVPIPVSVVPTL-----LAKSSAMYNPIIYQVVD 338
Cdd:cd15091   240 LG---SVSHSTAAVSSYyfciaLGYTNSSLNPILYAFLD 275
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-334 6.34e-15

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 74.42  E-value: 6.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKP-PELMTVNLAIFDFgISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15093    10 VCLVGLCGNSLVIYV-VLRYAKMKTvTNIYILNLAIADE-LFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTS-CTLDWWLAQASLSGqTF 227
Cdd:cd15093    88 FCLTVMSVDRYLAVVHpIKSARWRRPRVAKVVNLAVWV-ASLLVILPVVVFAGTRENQDGSSaCNMQWPEPAAAWSA-GF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF-- 305
Cdd:cd15093   166 IIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRS-----ERKVTRMVVMVVVVFVICWLPFYVLQLVNVFvq 240
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 306 GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15093   241 LPETPALVGVYHFVVILSYANSCANPILY 269
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
71-334 9.20e-15

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 73.87  E-value: 9.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15096    10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPL-----IGWGNYAPEPfGTSCTLDWwlaQASLSG 224
Cdd:cd15096    90 TLVLMSLDRYLAVVHpITSMSIRTERNTLIAIVGIWI-VILVANIPVlflhgVVSYGFSSEA-YSYCTFLT---EVGTAA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSStkeVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15096   165 QTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQ---KSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKY 241
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 305 FGEPDSVPIPVSVVPT--LLAKSSAMYNPIIY 334
Cdd:cd15096   242 YGVLPETVLYVVIQILsnCLAYGNSCVNPILY 273
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
73-334 1.19e-14

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 73.07  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKtKLKPP-ELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15329    12 LGTVVGNALVIIAVCLVK-KLRTPsNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILN 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLaqaslsgQTFVMA 230
Cdd:cd15329    91 LCAISVDRYLVITRpLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQDFGY-------QIYATF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFcliLPTGIIVFSYVMiIFKVKSStkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15329   164 GAFY---IPLIVMLVLYYK-IYRAAKS-----------------ERKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIK 222
                         250       260
                  ....*....|....*....|....*..
gi 2116730773 311 V-PIPVSVVPTL--LAKSSAMYNPIIY 334
Cdd:cd15329   223 CsCIPLWLSRLFlwLGYANSFLNPIIY 249
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
78-334 1.20e-14

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 73.45  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAHR-WLFGWEGCQFygwAGFFFGC---GSLITMT 153
Cdd:cd14982    17 GNILALWVFLRKMKKRSPTTIYMINLALADL-LFVLTLPFRIYYYLNGGwWPFGDFLCRL---TGLLFYInmyGSILFLT 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 154 MVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGN-YAPEPFGTSC--TLDWWLAQAslsgQTFVM 229
Cdd:cd14982    93 CISVDRYLAVVHpLKSRRLRRKRYAVGVCAGVWI-LVLVASVPLLLLRStIAKENNSTTCfeFLSEWLASA----APIVL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSSTKEvshfdariNNSHNLEMKLTKVAMLICAGFLIAWIPY-----AVVSVVSA 304
Cdd:cd14982   168 IALVVGFLIPLLIILVCYSLIIRALRRRSKQ--------SQKSVRKRKALRMILIVLAVFLVCFLPYhvtriLYLLVRLS 239
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 305 FGEPDSVPIPVSV---VPTLLAKSSAMYNPIIY 334
Cdd:cd14982   240 FIADCSARNSLYKayrITLCLASLNSCLDPLIY 272
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
69-340 1.37e-14

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 73.54  E-value: 1.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGI-MSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd15065     6 LSLIIvLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPL-IGWGNYAPEPFGTSCTLDWWLAQASLSgQ 225
Cdd:cd15065    86 SILNLCAISLDRYIHIKKpLKYERWMTTRRALVVIASVWILSALISFLPIhLGWHRLSQDEIKGLNHASNPKPSCALD-L 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAIL--FFCLILPTGIIVFSYVMIIF-------KVKSSTKEVSHFD--------ARINNSHNLEMKLTKVAMLICAG 288
Cdd:cd15065   165 NPTYAVVssLISFYIPCLVMLLIYSRLYLyarkhvvNIKSQKLPSESGSkfqvpslsSKHNNQGVSDHKAAVTLGIIMGV 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2116730773 289 FLIAWIPYAVVSVVSAFgEPDSVPIPVSVVPTLLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15065   245 FLICWLPFFIINIIAAF-CKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSE 295
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
73-334 2.02e-14

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 72.36  E-value: 2.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIyMTIKRKTKL-KPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygWAGFFFGC--GSL 149
Cdd:cd15064    12 LATILGNALVI-AAILLTRKLhTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDI--WISLDVTCctASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKIC-HLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGW-GNYAPEPfgTSCTLdwwlaQASLSGQTF 227
Cdd:cd15064    89 LHLCVIALDRYWAITdAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWrTPDSEDP--SECLI-----SQDIGYTIF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFcliLPTGIIVFSYvmiifkvksstkevshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15064   162 STFGAFY---IPLLLMLILY------------------WKIYRAAARERKAAKTLGIILGAFIVCWLPFFLVALIVPLCS 220
                         250       260
                  ....*....|....*....|....*..
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15064   221 HCWIPLALKSFFLWLGYFNSLINPLIY 247
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
71-337 6.07e-14

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 71.76  E-value: 6.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYM--TIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFA-HRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd14976    10 VFTVGLLGNLLVLYLlkSNKKLRQQSESNKFVFNLALTDLIFVLT-LPFWAVEYALdFVWPFGTAMCKVVRYVTKLNMYS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFG-TSCTLDWwLAQASLSGQ 225
Cdd:cd14976    89 SIFFLTALSVTRYIAVARaLKHGWIRKAFGAFATTIAIWAAAAL-AAIPEAIFSTDTWSSVNhTLCLLRF-PKNSSVTRW 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAI-----LFFCLILPTGIIVFSYVMIIFKVKsstkevshfDARINNSHNLEmKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd14976   167 YNWLGMyqlqkVVLGFFLPLGIITLSYLLLLRFLQ---------RKRGGSKRRKS-RVTKSVFIVVLSFFICWLPNQALS 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 301 VVSAFGEPDSVPIPVSV---------VPTLLAKSSAMYNPIIYQVV 337
Cdd:cd14976   237 LWSALIKFDDVPFSDAFfafqtyafpVAICLAHSNSCLNPVLYCLV 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
73-334 7.89e-14

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 70.88  E-value: 7.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGCG---SL 149
Cdd:cd15206    12 LLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKL---IPYFQAVSvsvST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATmPLIGWGNYAP--EPFGTSCTLDWWLAQASLSGQT 226
Cdd:cd15206    89 FTLVAISLERYFAICHpLKSRVWQTLSHAYKVIAGIWLLSFLIMS-PILVFSNLIPmsRPGGHKCREVWPNEIAEQAWYV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFcliLPTGIIVFSYVMIIFKVKSSTKEVshfdarinnshnlemklTKVAMLICAGFLIAWIPYAVVSVVSAFG 306
Cdd:cd15206   168 FLDLMLLV---IPGLVMSVAYGLISWTLLEAKKRV-----------------IRMLFVIVVEFFICWTPLYVINTWKAFD 227
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 307 EPDSV----PIPVSVVpTLLAKSSAMYNPIIY 334
Cdd:cd15206   228 PPSAAryvsSTTISLI-QLLAYISSCVNPITY 258
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
71-334 7.95e-14

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 70.85  E-value: 7.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15061     9 AIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASIL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGtSCTLDWWLAQASLSGqtfvM 229
Cdd:cd15061    89 NLCCISLDRYFAITYpLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLG-SCYYTYDKGYRIYSS----M 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFfcliLPTGIIVFSYVMiIFKVKSStkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPD 309
Cdd:cd15061   164 GSFF----LPLLLMLFVYLR-IFRVIAK-----------------ERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDCQ 221
                         250       260
                  ....*....|....*....|....*
gi 2116730773 310 SVPIPVSVVpTLLAKSSAMYNPIIY 334
Cdd:cd15061   222 FSEALSTAF-TWLGYFNSVINPFIY 245
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
78-338 8.62e-14

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 71.09  E-value: 8.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGC---GSLITMTM 154
Cdd:cd15402    17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQI---SGFLMGLsviGSIFNITG 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAPEPFGTSCTldwwLAQASLSGQTfvMAILF 233
Cdd:cd15402    94 IAINRYCYICHsLKYDKLYSDKNSLCYVLLIWVL-TVAAIVPNLFVGSLQYDPRIYSCT----FAQSVSSAYT--IAVVF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICagFLIAWIPYAVVSVVSAFGEPDSVP- 312
Cdd:cd15402   167 FHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVL--FAVCWAPLNFIGLAVAVDPETIVPr 244
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 313 IP--VSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15402   245 IPewLFVASYYMAYFNSCLNAIIYGLLN 272
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
103-333 8.73e-14

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 71.12  E-value: 8.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 103 LAIFDF-GISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd14981    44 LAITDLlGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHpFFYNSHVKKRRARLM 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 181 LVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFCLILPTgiIVFSYVMIIF----KVKS 256
Cdd:cd14981   124 LGAVWAFALLIASLPLLGLGSYVLQYPGTWCFLDFYSKNTGDAAYAYLYSILGLLILLVT--LLCNLLVIITllrmRRRK 201
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 257 STKEVSHFDARINNSHNLEMKLTKVAMLICagFLIAWIPYAVVSVVSAFGEPdsvpiPVSVVPTLLAKSSAMYNPII 333
Cdd:cd14981   202 KRHRRSRRSARRQKRNEIQMVVLLLAITVV--FSVCWLPLMIRVLINATGDS-----EKNGKTDLLAVRMASWNQIL 271
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
73-334 9.58e-14

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 71.00  E-value: 9.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15202    12 VFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHLRYGTWLKRHHAFLCLVfVWVYAAFWATMPLIGWG----NYAPEPFGTSCTLDwWLAQASLSGQTFV 228
Cdd:cd15202    92 TAIAVDRYQAIMHPLKPRISKTKAKFIIAV-IWTLALAFALPHAICSKletfKYSEDIVRSLCLED-WPERADLFWKYYD 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 229 MAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP 308
Cdd:cd15202   170 LALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLSSKPD 249
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 309 DSV-PIPVSVVPTL-LAKSSAMYNPIIY 334
Cdd:cd15202   250 YLIkTINAVYFAFHwLAMSSTCYNPFIY 277
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
66-334 1.09e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 70.42  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIyMTIKRKTKLKPpelMT----VNLAIFDFGISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWA 140
Cdd:cd15052     5 LLLLLLVIATIGGNILVC-LAISLEKRLQN---VTnyflMSLAIADLLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 141 GFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPE--PFGTSCTldwwl 217
Cdd:cd15052    81 DVLFCTASIMHLCTISLDRYMAIRYpLRTRRNKSRTTVFLKIAIVWL-ISIGISSPIPVLGIIDTTnvLNNGTCV----- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 aqasLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVksstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYA 297
Cdd:cd15052   155 ----LFNPNFVIYGSIVAFFIPLLIMVVTYALTIRLL------------------SNEQKASKVLGIVFAVFVICWCPFF 212
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 298 VVSVVSAFGEPDSVPIP--VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15052   213 ITNILTGLCEECNCRISpwLLSVFVWLGYVSSTINPIIY 251
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
70-303 1.96e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 69.85  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  70 SVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15399     9 SIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKIC-HLryGTWLKRHHAFLCLVFVWVYAAFWATmPLIGWGNYA----PEPFGTSCTLDWWLAQASLSG 224
Cdd:cd15399    89 VTLTVIALDRHRCIVyHL--ESKISKKISFLIIGLTWAASALLAS-PLAIFREYSvieiSPDFKIQACSEKWPNGTLNDG 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSstkEVSHFDARiNNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15399   166 TIYSVSMLLIQYVLPLAIISYAYIRIWTKLKN---HVSPGGGN-DHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLAS 240
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
66-334 2.43e-13

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 69.59  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFgwEGCQFYGWAGFFFG 145
Cdd:cd14968     5 VLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF--HGCLFMACLVLVLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSG 224
Cdd:cd14968    83 QSSIFSLLAIAIDRYLAIKIpLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGIQCLFEEVIPM 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNL--EMKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd14968   163 DYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRSTLqkEVKAAKSLAIILFLFALCWLPLHIINCI 242
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 303 SAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14968   243 TLFCPECKVPKILTYIAILLSHANSAVNPIVY 274
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
66-334 3.03e-13

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 69.45  E-value: 3.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFG 145
Cdd:cd15972     5 LVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYapePFGTSCTLDWWLAQASLSG 224
Cdd:cd15972    84 FTSIFCLTVMSVDRYLAVVHpIRSSKWRKPPVAKTVNATVWA-LSFLVVLPVVIFSGV---PGGMGTCHIAWPEPAQVWR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVM---AILFFClilPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlEMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15972   160 AGFIIytaTLGFFC---PLLVICLCYLLIVVKVRSSGRRVRATSTKRRGS---ERKVTRMVVIVVAAFVLCWLPFYALNI 233
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2116730773 302 VSAFG----EPDSVPIPVSVVPTLLAKSSAmyNPIIY 334
Cdd:cd15972   234 VNLVCplpeEPSLFGLYFFVVVLSYANSCA--NPIIY 268
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
63-337 3.33e-13

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 69.69  E-value: 3.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  63 GVRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSF-AHRWLFGWEGCQFYGWAG 141
Cdd:cd14979     2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGW--------GNYAPEPFGTSCT 212
Cdd:cd14979    82 EACTYATVLTIVALSVERYVAICHpLKAKTLVTKRRVKRFILAIWLVSILCA-IPILFLmgiqylngPLPGPVPDSAVCT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 213 LDwwLAQASLSGQTFVMAILFFCliLPTGIIVFSYVMIIFKVKS------STKEVSHFDARINNSHNLEMKLTKVAMLIC 286
Cdd:cd14979   161 LV--VDRSTFKYVFQVSTFIFFV--LPMFVISILYFRIGVKLRSmrnikkGTRAQGTRNVELSLSQQARRQVVKMLGAVV 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 287 AGFLIAWIPYAV----VSVVSAFGEPDS-VPIPVSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd14979   237 IAFFVCWLPFHAqrlmFSYASKEDTFLFdFYQYLYPISGILFYLSSAINPILYNLM 292
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
71-334 4.14e-13

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 68.84  E-value: 4.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFF-FGCgSL 149
Cdd:cd15001     9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLsFIC-SV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNY----APEPFGTSCTLDWWlaqASLSG 224
Cdd:cd15001    88 LTLTAISIERYYVILHpMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVryesENGVTVYHCQKAWP---STLYS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVmiifkvksstkevshfdarinnsHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15001   165 RLYVVYLAIVIFFIPLIVMTFAYA-----------------------RDTRKQVIKMLISVVVLFAVCWGPLLIDNLLVS 221
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2116730773 305 FGEPDSVPI----PVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15001   222 FDVISTLHTqalkYMRIAFHLLSYANSCINPIIY 255
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
78-305 4.69e-13

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 68.78  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFD--FGISVtgkPFFIVSsFAHRWLFGWEGCQFYGW---AGFFfgCGSLITM 152
Cdd:cd14984    17 GNSLVLLVLLYYRKLRSMTDVYLLNLALADllFVLTL---PFWAVY-AADGWVFGSFLCKLVSAlytINFY--SGILFLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMvSLDRYLKICHLRYGTWLKR-HHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDwWLAQASLSGQTFV-MA 230
Cdd:cd14984    91 CI-SIDRYLAIVHAVSALRARTlLHGKLTCLGVWALALL-LSLPEFIFSQVSEENGSSICSYD-YPEDTATTWKTLLrLL 167
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd14984   168 QNILGFLLPLLVMLFCYSRIIRTLLRARNHKKH-------------RALRVIFAVVVVFFLCWLPYNIVLLLDTL 229
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
70-334 4.81e-13

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 68.97  E-value: 4.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  70 SVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15393     9 IISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRhhAFLCLVFVWVYAAFWAT-MPLIGWGNYAPEPFGTS----C-----TLDWWla 218
Cdd:cd15393    89 FTLTVIAVDRYRAVIHpLKARCSKKS--AKIIILIIWILALLVALpVALALRVEELTDKTNNGvkpfClpvgpSDDWW-- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 qaslsgQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15393   165 ------KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQT 238
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 299 VSVVSAFGEPDSVPIPVSVV---PTLLAKSSAMYNPIIY 334
Cdd:cd15393   239 YNLLNEIKPEINKYKYINIIwfcSHWLAMSNSCYNPFIY 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
64-334 5.53e-13

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 68.94  E-value: 5.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVgIMSAT--GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAG 141
Cdd:cd14986     2 SRVAVLGV-LFVFTlvGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICHlRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNyapEPFGTSCTLDWWLAQAS 221
Cdd:cd14986    81 VVGLFASTYILVSMSLDRYQAIVK-PMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVE---RELGDGVHQCWSSFYTP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMAILFFCLILPTGIIVFSYVMIIFKV--KSSTKEVSH--FDARINNSHNL-----------EMKLTKVAMLIC 286
Cdd:cd14986   157 WQRKVYITWLATYVFVIPLIILSYCYGRILRTIwiRSRQKTDRPiaPTAMSCRSVSCvssrvslisraKIKTIKMTLVII 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2116730773 287 AGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14986   237 LAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIY 284
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
73-334 5.88e-13

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 68.54  E-value: 5.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSF-AHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15392    12 VLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLiLQYWPFGEFMCPVVNYLQAVSVFVSAFT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRygTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTS---CTLDWWLAQASLSGQTF 227
Cdd:cd15392    92 LVAISIDRYVAIMWpLR--PRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGqyiCTESWPSDTNRYIYSLV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFcliLPTGIIVFSYVMIIFKV---KSSTKEVSHFDARINNShnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15392   170 LMILQYF---VPLAVLVFTYTRIGIVVwakRTPGEAENNRDQRMAES---KRKLVKMMITVVAIFALCWLPLNILNLVGD 243
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 305 FGEPDSV--PIPVSVVPT-LLAKSSAMYNPIIY 334
Cdd:cd15392   244 HDESIYSwpYIPYLWLAAhWLAMSHCCYNPFIY 276
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
64-334 6.68e-13

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 68.58  E-value: 6.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSV-GIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGC---QFYGW 139
Cdd:cd15195     2 VRVLVTWVlFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCrvmMFLKQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGcgSLITMTMvSLDRYLKICH-LRYGTWLKRHHAFLCLVfvWVYAAFWATMPLIGW--GNYAPEPFGTSCTLDWW 216
Cdd:cd15195    82 FGMYLS--SFMLVVI-ALDRVFAILSpLSANQARKRVKIMLTVA--WVLSALCSIPQSFIFsvLRKMPEQPGFHQCVDFG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 217 LAQASLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKE------VSHFDARINNSHNLEMKLTKVAMLICAGFL 290
Cdd:cd15195   157 SAPTKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRardtpiSNRRRSRTNSLERARMRTLRMTALIVLTFI 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 291 IAWIPYAVVSVVSAFGEPDSVPIP--VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15195   237 VCWGPYYVLGLWYWFDKESIKNLPpaLSHIMFLLGYLNPCLHPIIY 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
69-334 7.53e-13

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 68.42  E-value: 7.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRktklkpPELMTV------NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGF 142
Cdd:cd15207     8 SLIFLLCVVGNVLVCLVVAKN------PRMRTVtnyfilNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCGSLITMTMVSLDRYLKICHLRYGTWLKRHhAFLCLVFVWVYAAfwATM-PLIGWGNYAPEPFG-----TSCTLDWW 216
Cdd:cd15207    82 VSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQ-AFVIIVAIWVLAL--AIMiPQALVLEVKEYQFFrgqtvHICVEFWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 217 laqASLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLI--CAGFLIAWI 294
Cdd:cd15207   159 ---SDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASREAQAAVSKKKVRVIKMLIvvVVLFALSWL 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 295 PYAVVSVVSAFG---EPDSVPIPVSVVPT---LLAKSSAMyNPIIY 334
Cdd:cd15207   236 PLHTVTMLDDFGnlsPNQREVLYVYIYPIahwLAYFNSCV-NPIVY 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
73-334 8.32e-13

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 68.09  E-value: 8.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15390    12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHlrygtWLKRHHAFLCLVFV----WVYAAFWATMPLIGWG----NYAPEPFGTSCTLDWWLAQASLSG 224
Cdd:cd15390    92 MAISIDRYIAIVH-----PLRPRLSRRTTKIAiaviWLASFLLALPQLLYSTtetyYYYTGSERTVCFIAWPDGPNSLQD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSStKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVsA 304
Cdd:cd15390   167 FVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGS-KTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLYFIL-T 244
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2116730773 305 FGEPDSVPIP----VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15390   245 YLYPDINSWKyiqqIYLAIYWLAMSNSMYNPIIY 278
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
67-334 1.07e-12

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 68.04  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  67 LDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFgwEGCQFYGWAGFFFGC 146
Cdd:cd15069     6 LELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDF--HSCLFLACFVLVLTQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 GSLITMTMVSLDRYLKIC-HLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNyapEPFGTSCTLDWWLAQASLSG- 224
Cdd:cd15069    84 SSIFSLLAVAVDRYLAIKvPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNK---AMSATNNSTNPADHGTNHSCc 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 -----------QTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAW 293
Cdd:cd15069   161 lisclfenvvpMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCW 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2116730773 294 IPYAVVSVVSAFGEPDSVPIP--VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15069   241 LPVHILNCITLFQPEFSKSKPkwAMNVAILLSHANSVVNPIVY 283
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
71-337 1.08e-12

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 67.52  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15063    10 LNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGW----GNYAPEPFGTSCTLDWWLAqaslSGQ 225
Cdd:cd15063    90 NLCAISLDRYLAITRpIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWndgkDGIMDYSGSSSLPCTCELT----NGR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAILFFCLILPTGIIVFSYVmiifkvksstkevshfdaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15063   166 GYVIYSALGSFYIPMLVMLFFYF------------------RIYRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAF 227
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 306 GEPDSVPIPVSVVPTLLAKSSAMyNPIIYQVV 337
Cdd:cd15063   228 CEDCIPPLLFSVFFWLGYCNSAL-NPCIYALF 258
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
78-334 1.21e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 67.22  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15326    17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPePFGTSC--TLDWWLAQASLSGQTFVMAILFF 234
Cdd:cd15326    97 DRYIGVRHsLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAP-PDDKVCeiTEEPFYALFSSLGSFYIPLIVIL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYvmiifkvksstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:cd15326   176 VMYCRVYIVALKF-------------------------SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPET 230
                         250       260
                  ....*....|....*....|
gi 2116730773 315 VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15326   231 LFKIIFWLGYFNSCLNPIIY 250
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
77-334 1.39e-12

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 67.44  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVI--YMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:cd15098    16 LGNSLVItvLARVKPGKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICHLRYGTWL-KRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFG--TSCTLDWWLAQASlsgQTFVMAI 231
Cdd:cd15098    96 MSVDRYIAVVHSRTSSSLrTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASnqTFCWENWPEKQQK---PVYVVCT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKVKSSTKEVShfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE-P-D 309
Cdd:cd15098   173 FVFGYLLPLLLITFCYAKVLNHLHKKLKNMS------KKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDfPlT 246
                         250       260
                  ....*....|....*....|....*
gi 2116730773 310 SVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15098   247 QASFVLRITAHCLAYANSCVNPIIY 271
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
69-334 1.75e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 66.93  E-value: 1.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgisVTGKPFFIVSSFahrwlFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd14972     6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADL---LAGIAFVFTFLS-----VLLVSLTPSPATWLLRKGSL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMT-------MVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnYAPEPFGTSCtldwwlaqa 220
Cdd:cd14972    78 VLSLLasaysllAIAVDRYISIVHgLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGW--NCVLCDQESC--------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SLSGQTFVMAILFFCLI---LPTGIIVFSYVMIIFKVKsstkevSHFDARINNSHNL-------EMKLTKVAMLICAGFL 290
Cdd:cd14972   147 SPLGPGLPKSYLVLILVfffIALVIIVFLYVRIFWCLW------RHANAIAARQEAAvpaqpstSRKLAKTVVIVLGVFL 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2116730773 291 IAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14972   221 VCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIY 264
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
69-338 1.98e-12

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 66.81  E-value: 1.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMtIKRKTKLKPP-ELMTVNLAIFDFGISVTgKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd15092     8 LIVCVVGLVGNCLVMYV-ILRHTKMKTAtNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTL------DWWlaqa 220
Cdd:cd15092    86 STFTLTAMSVDRYVAICHpIKALDVRTPHKAKVVNVCIWALASVVG-VPVMVMGSAQVEDEEIECLVeiptpqDYW---- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 slsGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSstkeVSHFDARINNSHNLEmKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd15092   161 ---DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRG----VRLLSGSKEKDRNLR-RITRLVLVVVAVFVGCWTPIQIFV 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 301 VVSAFG-EPDSV-PIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15092   233 LAQGLGvQPSSEtAVAILRFCTALGYVNSSLNPVLYAFLD 272
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
78-334 2.35e-12

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 66.71  E-value: 2.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYViyMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSS---FAHRwLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:cd15220    16 GNTAV--MVVIAKTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSspfFLGV-VFGEAECRVYIFLSVCLVSASILTISA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNY-APEPFGTSCTLDWWlaqaSLSGQTFVMAIL 232
Cdd:cd15220    93 ISVERYYYIVHpMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYgGPAPIAARHCSLHW----SHSGHRGVFVVL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 F--FCLILPTGIIVFSYVMiIFKVKSSTKEVShfdarinnshnlemkltkVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15220   169 FalVCFLLPLLLILVVYCG-VFKVFGGGKAAL------------------TLAAIVGQFLCCWLPYFAFHLYSALAASPV 229
                         250       260
                  ....*....|....*....|....
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15220   230 SGGEAEEVVTWLAYSCFAVNPFFY 253
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
78-302 3.19e-12

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 66.57  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAH-RWLFGWEGCQFygwAGFFFGC---GSLITMT 153
Cdd:cd15168    17 LNSVVLYRFIFHLKPWNSSAIYMFNLAVSDL-LYLLSLPFLIYYYANGdHWIFGDFMCKL---VRFLFYFnlyGSILFLT 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 154 MVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSC---TLDWWLAQASLSGqtFVM 229
Cdd:cd15168    93 CISVHRYLGICHpLRSLGKLKKRHAVAISVAVWI-LVLLQLLPILFFATTGRKNNRTTCydtTSPEELNDYVIYS--MVL 169
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 230 AILFFCliLPTGIIVFSYVMIIFKVKSSTKEVShfdarinnSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15168   170 TGLGFL--LPLLIILACYGLIVRALIRKLGEGV--------TSALRRKSIRLVIIVLALFAVCFLPFHVTRTI 232
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
77-334 4.12e-12

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 65.79  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKlKPPELMTVNLAIFDFgISVTGKPFFIVSS-FAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd14974    16 PGNGLVIWVAGFKMKR-TVNTVWFLNLALADF-LFCLFLPFLIVYIaMGHHWPFGSVLCKLNSFVISLNMFASVFLLTAI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHlryGTWLKRHH----AFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQA-SLSGQTFVMA 230
Cdd:cd14974    94 SLDRCLLVLH---PVWAQNHRtvrlASVVCVGIWI-LALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDlRRSRHKALTV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFC-LILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPd 309
Cdd:cd14974   170 IRFLCgFLLPLLIIAICYSVIAVKLRRKRLAKSS-------------KPLRVLLAVVVAFFLCWLPYHVFALLELVAAA- 235
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 310 sVPIPVSVVPTLLAKSSAMY----NPIIY 334
Cdd:cd14974   236 -GLPEVVLLGLPLATGLAYFnsclNPILY 263
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
73-338 4.96e-12

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 65.70  E-value: 4.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15401    12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTW--LKRHHAFLCLVFVWVYAAFwatMPLIGWGNYAPEPFGTSCTldwwLAQASLSGQTFVM 229
Cdd:cd15401    92 TAIAINRYCYICHsLRYDKLynMKKTCCYVCLTWVLTLAAI---VPNFFVGSLQYDPRIYSCT----FAQTVSSSYTITV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFclILPTGIIVFSYVMI---IFKVKSSTKEVSHFDARINNSHNLemkLTKVAMLICagFLIAWIPYAVVSVVSAFG 306
Cdd:cd15401   165 VVVHF--IVPLSIVTFCYLRIwvlVIQVKHRVRQDSKQKLKANDIRNF---LTMFVVFVL--FAVCWGPLNFIGLAVAIN 237
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 307 EPDSVP-IP--VSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15401   238 PLKVAPkIPewLFVLSYFMAYFNSCLNAVIYGVLN 272
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
66-334 8.11e-12

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 65.17  E-value: 8.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR-WLFGWEGCQFYGWAGFFF 144
Cdd:cd15212     5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPgWLFGDRLCLANGFFNACF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 145 GCGSLITMTMVSLDRYLKICHLRYGTWLKRhHAFLCLVFVWVYA-AFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLS 223
Cdd:cd15212    85 GIVSTLTMTLISFDRYYAIVRQPQGKIGRR-RALQLLAAAWLTAlGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDA-----RINNshnlEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15212   164 GAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTyahllRFYS----EMRTATTVLIMIVFIICCWGPYCL 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2116730773 299 VSVVSAFGEPdSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15212   240 LGLVAAAGGY-QFPPLMDTVAIWMAWANGAINPLIY 274
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
71-334 8.58e-12

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 64.88  E-value: 8.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMtIKRKTKLKPP-ELMTVNLAIFD--FGISVtgkPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd15973    10 VCLVGLIGNSMVIFV-ILRYAKMKTAtNIYILNLAIADelFMLSV---PFLAASAALQHWPFGSAMCRTVLSVDGINMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSgqt 226
Cdd:cd15973    86 SVFCLTVLSVDRYIAVVHpLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAA--- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF- 305
Cdd:cd15973   163 FVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKS-----EKKITRMVLMVVTVFVICWMPFYVVQLLNLFl 237
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 306 GEPDSVPIPVSVVptlLAKSSAMYNPIIY 334
Cdd:cd15973   238 PRLDATVNHASLI---LSYANSCANPILY 263
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-334 1.02e-11

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 64.86  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd16004    12 LVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHlRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAIL 232
Cdd:cd16004    92 TAIAADRYMAIIH-PFKPRLSAGSTKVVIAGIWL-VALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKHQLTYHLAVI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP---D 309
Cdd:cd16004   170 VLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNEDiycQ 249
                         250       260
                  ....*....|....*....|....*
gi 2116730773 310 SVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd16004   250 KYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
101-334 1.44e-11

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 64.66  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 101 VNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFL 179
Cdd:cd15051    40 VSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITApLRYPSRVTPRRVAI 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 180 CLVFVWVYAAFWATMPL-IGW----GNYAPEPFGTSCTLDWwlaqaslsGQTFVMAILFFCLILPTGIIVFSYVMIIFKV 254
Cdd:cd15051   120 ALAAIWVVSLAVSFLPIhLGWntpdGRVQNGDTPNQCRFEL--------NPPYVLLVAIGTFYLPLLIMCGVYLRIFRIA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 255 KSSTKEVSHFD----ARINNSHNL--EMKLTK-VAMLICAgFLIAWIPYAVVSVVSAFgEPDSVPIPVSVVPTLLAKSSA 327
Cdd:cd15051   192 REQAKRINALTpastANSSKSAATarEHKATVtLAAVLGA-FIICWFPYFTYFTYRGL-CGDNINETALSVVLWLGYANS 269

                  ....*..
gi 2116730773 328 MYNPIIY 334
Cdd:cd15051   270 ALNPILY 276
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
78-338 1.70e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 63.82  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15210    17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICHLR-YGTWLKRHHAFLCLVFVWVYAAFWATMPLIG-WGNYAPEPFGTSCTLDWWLAQASLsgQTFVMAILFfc 235
Cdd:cd15210    97 NRYILIAHPSlYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCSCSILRDKKGRSP--KTFLFVFGF-- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 lILPTGIIVFSYVMiifkvksstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDsvpiPV 315
Cdd:cd15210   173 -VLPCLVIIICYAR-----------------------REDRRLTRMMLVIFLCFLVCYLPITLVNVFDDEVAPP----VL 224
                         250       260
                  ....*....|....*....|...
gi 2116730773 316 SVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15210   225 HIIAYVLIWLSSCINPIIYVAMN 247
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
78-334 2.98e-11

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 63.60  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIK-RKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGwEGCQFygWAGFFFGC--GSLITMTM 154
Cdd:cd15057    17 GNALVIAAVLRfRHLRSKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDV--WVSFDIMCstASILNLCV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPL-IGWGNYAPEPFGTSCTLDWWLAQASLSgQTFVMAIL 232
Cdd:cd15057    94 ISVDRYWAISSpFRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRADDTSEALALYADPCQCDSSLN-RTYAISSS 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHN----------LEMKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15057   173 LISFYIPVAIMIVTYTRIYRIARRQIRRIAALERAAQESTNpdsslrsslrRETKALKTLSIIMGVFVCCWLPFFILNCV 252
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2116730773 303 SAF-----GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15057   253 LPFcdlrtAQFPCVPDTTFIVFVWLGWANSSLNPIIY 289
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
71-338 4.05e-11

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 63.09  E-value: 4.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIkRKTKLKPP-ELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15090    10 VCVVGLFGNFLVMYVIV-RYTKMKTAtNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTLDW----WLAQASLSg 224
Cdd:cd15090    88 FTLCTMSVDRYIAVCHpVKALDFRTPRNAKIVNVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFshpsWYWENLLK- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 qtfvMAILFFCLILPTGIIVFSYVMIIFKVKSstkeVSHFDARINNSHNLEmKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15090   166 ----ICVFIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPIHIYVIIKA 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 305 FgepdsVPIPVSVVPTL-------LAKSSAMYNPIIYQVVD 338
Cdd:cd15090   237 L-----VTIPETTFQTVswhfciaLGYTNSCLNPVLYAFLD 272
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
78-334 5.66e-11

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 62.49  E-value: 5.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15209    17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLdwwlaqASLSGQTFVMAILFFCL 236
Cdd:cd15209    97 NRYCYICHsLQYDRLYSLRNTCCYLCLTWLLTVL-AVLPNFFIGSLQYDPRIYSCTF------AQTVSTVYTITVVVIHF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 237 ILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICagFLIAWIPYAVVSVVSAFGEPDSVP-IP- 314
Cdd:cd15209   170 LLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVL--FAVCWAPLNFIGLAVAINPKEMAPkIPe 247
                         250       260
                  ....*....|....*....|.
gi 2116730773 315 -VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15209   248 wLFVASYFMAYFNSCLNAIIY 268
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
94-318 5.89e-11

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 62.17  E-value: 5.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  94 KPPELMTV------NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-L 166
Cdd:cd15215    26 RKPQLLQVanrfifNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHpL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 167 RYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWwlaqASLSGQTFVMAILFFclILPTGIIVFS 246
Cdd:cd15215   106 SYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCSVIW----GSSYSYTILSVVSSF--VLPVIIMLAC 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2116730773 247 YVMIifkvksstkevshFDARINNSHnleMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVV 318
Cdd:cd15215   180 YSMV-------------FRAARRCYH---CKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQVPQWVISII 235
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
78-336 6.93e-11

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 61.97  E-value: 6.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15059    17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGtsctldwwLAQASLSgqTFVMAILFFCL 236
Cdd:cd15059    97 DRYWSVTQaVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGA--------EPQCELS--DDPGYVLFSSI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 237 ---ILPTGIIVFSYVMIIFKVKSStkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPI 313
Cdd:cd15059   167 gsfYIPLLIMIIVYARIYRAAKRK-----------------ERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPE 229
                         250       260
                  ....*....|....*....|...
gi 2116730773 314 PVSVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15059   230 LLFKFFFWLGYCNSALNPVIYTI 252
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
101-334 8.34e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 61.83  E-value: 8.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 101 VNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFL 179
Cdd:cd15325    40 VNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYpLRYPSIMTERRGLL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 180 CLVFVWVYAAFWATMPLIGWGNYAPEPfGTSCTLDwwlaqaslSGQTFVMAILFFCLILPTGIIVFSYVMI-IFKVKSST 258
Cdd:cd15325   120 ALLCVWVLSLVISIGPLFGWKEPAPED-ETICQIT--------EEPGYALFSALGSFYLPLAIILVMYCRVyVVALKFSR 190
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 259 kevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15325   191 ----------------EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIY 250
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
73-333 1.25e-10

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 61.75  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTV--NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15142    12 IFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVM 229
Cdd:cd15142    92 IICAMSIERYLAINHaYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLGKSKLQYPKTWCFIDWRTNVSVHAAYSYMY 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPT---------GIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAG--FLIAWIPYAV 298
Cdd:cd15142   172 AGFSSLLILVTvlcnvlvcgALIRMHRQFVRRTSLGTDQRLSDFRRRRSFRRMAGAEIQMVILLIATSvvVLICSIPLVV 251
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 299 VSVVSAFGEPDSVPIPvSVVPTLLAKSSAMYNPII 333
Cdd:cd15142   252 RVFVNQLYQPAVEKDL-DKNPDLQAIRIASVNPIL 285
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-334 1.26e-10

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 61.80  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd16002    12 VVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVfvWVYAAFWAtMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAI 231
Cdd:cd16002    92 TAIALDRYMAIIHpLQPRLSATATKVVICVI--WVLAFLLA-FPQGYYSDTEEMPGRVVCYVEWPEHEERKYETVYHVCV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP--- 308
Cdd:cd16002   169 TVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSD-RYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFHPElye 247
                         250       260
                  ....*....|....*....|....*.
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd16002   248 QKFIQQVYLAIMWLAMSSTMYNPIIY 273
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
73-339 1.27e-10

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 61.29  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15060    12 AFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGtwLKRHHAFLCL--VFVWVYAAFWATMPLIGWGNYaPEPF--GTSCTLDwwlaqaslSGQTF 227
Cdd:cd15060    92 CAIALDRYWAIHDpINYA--QKRTLKRVLLmiVVVWALSALISVPPLIGWNDW-PENFteTTPCTLT--------EEKGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFkvkSSTKevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15060   161 VIYSSSGSFFIPLLIMTIVYVKIFI---ATSK---------------ERRAARTLGIIMGVFVVCWLPFFLMYVILPFCE 222
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIYQVVDL 339
Cdd:cd15060   223 TCSPSAKVVNFITWLGYVNSALNPVIYTIFNL 254
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
73-334 1.35e-10

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 61.32  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTiKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15115    12 LLGVPGNGLVIWVA-GLKMKRTVNTIWFLNLAVADL-LCCLSLPFSIAHLLLNgHWPYGRFLCKLLPSIIVLNMFASVFT 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICHlryGTWLKRHH----AFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQaslsgqTF 227
Cdd:cd15115    90 LTAISLDRFLLVIK---PVWAQNHRsvllACLLCGCIWI-LALLLCLPVFIYRTTVTDGNHTRCGYDFLVAI------TI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFclILPTGIIVFSYVMIIFKVKSStkevshfdarinNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15115   160 TRAVFGF--LLPLLIIAACYSFIAFRMQRG------------RFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGD 225
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 308 PDS--VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15115   226 PPLskVLMSWDHLSIALAYANSCLNPVLY 254
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
101-334 1.63e-10

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 61.55  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 101 VNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKIchlRYGTWLKRHHAF-- 178
Cdd:cd15048    40 LNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSV---TKAVKYRAKQTKrr 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 179 --LCLVFVWVYAAFWATMPLIGW---GNYAPEPFGtSCTLDWWLAQASlsgqTFVMAILFFCliLPTGIIVFSYVMIIFK 253
Cdd:cd15048   117 tvLLMALVWILAFLLYGPAIIGWdlwTGYSIVPTG-DCEVEFFDHFYF----TFITSVLEFF--IPFISVSFFNLLIYLN 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 254 V-KSSTKEVSHFDARINNSHNLE--------------MKLTKV-AMLICAgFLIAWIPYAVVSVVSAFGEPDSVPIPVSV 317
Cdd:cd15048   190 IrKRSRRRPLRSVPILPASQNPSrarsqreqvklrrdRKAAKSlAILVLV-FLICWAPYTILTIIRSFCSGSCVDSYLYE 268
                         250
                  ....*....|....*..
gi 2116730773 318 VPTLLAKSSAMYNPIIY 334
Cdd:cd15048   269 FTFWLLWTNSAINPFLY 285
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
148-334 2.58e-10

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 60.85  E-value: 2.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIgWGNYAPEPFGTSCTLDWWLAQAslsgqt 226
Cdd:cd15104    87 SVLSLAAIAFDRYLALKQpLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI-SPQFQQTSYKGKCSFFAAFHPR------ 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 fVMAILFFCLILPTGIIVFSYVMIIFKVKS------STKEVSHFDARINNSHNLEMKLTK-VAMLICAgFLIAWIPYAVV 299
Cdd:cd15104   160 -VLLVLSCMVFFPALLLFVFCYCDILKIARvhsraiYKVEHALARQIHPRRTLSDFKAARtVAVLIGC-FLLSWLPFQIT 237
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2116730773 300 SVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15104   238 GLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIY 272
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
78-336 2.90e-10

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 60.32  E-value: 2.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15321    23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGT-SCTLD---WWLAQASLSGqtfvmail 232
Cdd:cd15321   103 DRYWSVSRaIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLpQCKLNeeaWYILSSSIGS-------- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FF--CLILptgIIVFSYVMIIFKvksstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGePDS 310
Cdd:cd15321   175 FFapCLIM---ILVYLRIYLIAK-------------------NREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAIC-PEL 231
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 311 VPIPVSVVPTL--LAKSSAMYNPIIYQV 336
Cdd:cd15321   232 CKVPHSLFQFFfwIGYCNSSLNPVIYTI 259
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
77-338 5.08e-10

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 59.70  E-value: 5.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIV-SSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd14985    16 LGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLT-LPLWATyTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTCM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGTWLKRH-HAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFG--TSCTLDWWLAQASLsGQTFVMAIL 232
Cdd:cd14985    95 SVDRYLAIVHPVASRRLRRRrQARVTCALIWVVACL-LSLPTFLLRSLQAIENLnkTACIMLYPHEAWHF-GLSLELNIL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFclILPTGIIVFSYVMIIFKVKssTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFG------ 306
Cdd:cd14985   173 GF--VLPLLIILTCYFHIARSLR--KRYERTGKNGRKRR-----KSLKIIFALVVAFLVCWLPFHFFKFLDFLAqlgair 243
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2116730773 307 --EPDSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd14985   244 pcFWELFLDLGLPIATCLAFTNSCLNPFIYVFVD 277
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
62-334 6.22e-10

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 59.53  E-value: 6.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  62 SGVRLLDLSVGIMSATGNGYVIyMTIKRKTKLKP-PELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWA 140
Cdd:cd15958     1 AGMSLLMALIVLLIVAGNVLVI-VAIGRTQRLQTlTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 141 GFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQ 219
Cdd:cd15958    80 DVLCVTASIETLCVIAIDRYLAITSpFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCCD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 AsLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNL----------------EMKLTKVAM 283
Cdd:cd15958   160 F-VTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEGRFHNTLTGlgrkckrrpsrilalrEQKALKTLG 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116730773 284 LICAGFLIAWIPYAVVSVVSAFGEpDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15958   239 IIMGVFTLCWLPFFLVNVVNVFNR-ELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
64-334 6.70e-10

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 59.35  E-value: 6.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPP--ELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAG 141
Cdd:cd15002     2 VPILLGVICLLGFAGNLMVIGILLNNARKGKPSliDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTLDW-WLAQA 220
Cdd:cd15002    82 HACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLP-LPQWLFRTVKQSEGVYLCILCIpPLAHE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SLSgqTFVMAILFFCLILPTGIIVFSYVMII-FKVKSSTKEvshfdariNNSHN--LEMKLTKVAMLICAGFLIAWIPyA 297
Cdd:cd15002   161 FMS--AFVKLYPLFVFCLPLTFALFYFWRAYgQCQRRGTKT--------QNLRNqiRSRKLTHMLLSVVLAFTILWLP-E 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 298 VVSVVSAFGEPDSVPIP---VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15002   230 WVAWLWLIHIKSSGSSPpqlFNVLAQLLAFSISSVNPIIF 269
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
71-334 7.58e-10

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 59.44  E-value: 7.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATG---NGYVIYmTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIvssfaHRWLFGWEgcqfygWAGFFFGCG 147
Cdd:cd15339     7 IGILCSTGlvgNILVLF-TIIRSRKKTVPDIYVCNLAVADL-VHIIVMPFLI-----HQWARGGE------WVFGSPLCT 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLIT------------MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGT-SCTL 213
Cdd:cd15339    74 IITSldtcnqfacsaiMTAMSLDRYIALVHpFRLTSLRTRSKTIRINLLVWA-ASFILVLPVWVYAKVIKFRDGLeSCAF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 214 DWwLAQASLSGQTFVMAILFFclILPTGIIVFSYVMIIFKVKSSTKEvSHFDARINNSHNLE--MKLTKVAMLICAGFLI 291
Cdd:cd15339   153 NL-TSPDDVLWYTLYQTITTF--FFPLPLILICYILILCYTWEMYRK-NKKAGRYNTSIPRQrvMRLTKMVLVLVGVFLV 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2116730773 292 AWIPYAVVSVVSAFGEPDSVPIPVSV-VPTLLAKSSAMYNPIIY 334
Cdd:cd15339   229 SAAPYHVIQLVNLSVSQPTLAFYVSYyLSICLSYASSSINPFLY 272
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
71-334 7.95e-10

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 59.05  E-value: 7.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygWAGFFFGC--GS 148
Cdd:cd15054    10 IILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPI--WYAFDVMCcsAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPL-IGWGNYAPEPFGTSCTldwwlaQASLSGQT 226
Cdd:cd15054    88 ILNLCVISLDRYLLIISpLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELGHERTLPNLT------SGTVEGQC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLI-------LPTGIIVFSYVMIIFKVKSStkevshfdarinnshnleMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15054   162 RLLVSLPYALVascltffLPSGAICFTYCRILLAARKA------------------LKASLTLGILLGMFFVTWLPFFVA 223
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 300 SVVSAFGepDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15054   224 NVVQAVC--DCVSPGLFDVLTWLGYCNSTMNPIIY 256
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
73-334 1.30e-09

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 58.60  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15384    12 VISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYIT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLclVFVWVYAAFWATmPLIGWGNYAPEPFGTSCT--LDWWLAQASLSGQTFVM 229
Cdd:cd15384    92 VLISLDRCVAILYpMKRNQAPERVRRMV--TVAWILSPIFSI-PQAVIFHVERGPFVEDFHqcVTYGFYTAEWQEQLYNM 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNS--------HNLEMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15384   169 LSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNRgpnrqrlfHKAKVKSLRMSAVIVTAFILCWTPYYVIMI 248
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 302 VSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15384   249 WFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
78-334 1.53e-09

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 58.61  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15317    17 GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWaTMPLIGWGNYAPEpfgtsctLDWWLAQASLSGQ---------TF 227
Cdd:cd15317    97 DRYYAVCDpLRYPSKITVQVAWRFIAIGWLVPGIY-TFGLIYTGANDEG-------LEEYSSEISCVGGcqllfnkiwVL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFcliLPTGIIVFSYVMIIF----KVKSSTKEVSHFDARINNS----HNLEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15317   169 LDFLTFF---IPCLIMIGLYAKIFLvarrQARKIQNMEDKFRSSEENSskasASRERKAAKTLAIVMGIFLFCWLPYFID 245
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 300 SVVSAFGEPDSVPIPVSVVPTLLAKSSAMyNPIIY 334
Cdd:cd15317   246 TIVDEYSNFITPAIVFDAVIWLGYFNSAF-NPFIY 279
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
75-334 1.75e-09

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 58.21  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  75 SATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:cd14992    14 SVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATmPLIGWGNYAPEPFGTSCtLDWWLAQASLSGQTFVMAILF 233
Cdd:cd14992    94 IAFDRYFAIIHpLKPRHRQSYTTTVIIIITIWVVSLLLAI-PQLYYATTEVLFSVKNQ-EKIFCCQIPPVDNKTYEKVYF 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FCL-----ILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGeP 308
Cdd:cd14992   172 LLIfvvifVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFF-P 250
                         250       260       270
                  ....*....|....*....|....*....|
gi 2116730773 309 DSVPIP----VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14992   251 LIMKEKhtlqVYYFLHWIAMSNSMYNPIIY 280
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
78-334 1.79e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 57.94  E-value: 1.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15400    17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTldwwLAQASLSGQTFVMAILFFcl 236
Cdd:cd15400    97 NRYCYICHsFAYDKLYSRWNTLLYVCLIWALTVV-AIVPNFFVGSLEYDPRIYSCT----FVQTASSSYTIAVVVIHF-- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 237 ILPTGIIVFSYVMI-IFKVKSSTKEVSHFDARINNShNLEMKLTKVAMLICagFLIAWIPYAVVSVVSAFGEPDSVP-IP 314
Cdd:cd15400   170 IVPITVVSFCYLRIwVLVIQVRRKVKSESKPRLKPS-DFRNFLTMFVVFVI--FAICWAPLNLIGLAVAINPQEMAPkVP 246
                         250       260
                  ....*....|....*....|..
gi 2116730773 315 --VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15400   247 ewLFVVSYFMAYFNSCLNAIIY 268
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
103-309 1.87e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 58.41  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 103 LAIFDFGISVTGkpFFIVSSFAHRWLFGWEGCQFYG-------WAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKR 174
Cdd:cd14978    41 LAVSDILVLLSA--LPLFLLPYIADYSSSFLSYFYAyflpyiyPLANTFQTASVWLTVALTVERYIAVCHpLKARTWCTP 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 175 HHAFLCLVFVWVYAA------FWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFclILPTGIIVFSYV 248
Cdd:cd14978   119 RRARRVILIIIIFSLllnlprFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVV--LLPFILLLILNI 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116730773 249 MIIFKV-KSSTKEVSHFDARINNSHNL--EMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPD 309
Cdd:cd14978   197 LLIRALrKSKKRRRLLRRRRRLLSRSQrrERRTTIMLIAVVIVFLICNLPAGILNILEAIFGES 260
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
73-334 2.13e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 57.63  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVtgkpFFIVSSFAHRWLFGWEG----CQFYGWAGFFFGCGS 148
Cdd:cd15196    12 VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAL----FNVLPQLIWDITYRFYGgdllCRLVKYLQVVGMYAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHhaFLCLVFV-WVYAAFWATMPLIGWGNYAPEPFGTSCtldWWLAQASLSGQT 226
Cdd:cd15196    88 SYVLVATAIDRYIAICHpLSSHRWTSRR--VHLMVAIaWVLSLLLSIPQLFIFSYQEVGSGVYDC---WATFEPPWGLRA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLILPTGIIVFSYVMIIFKV-KSSTKEVshfdarinnshnlemKLTKVamlICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15196   163 YITWFTVAVFVVPLIILAFCYGRICYVVwRAKIKTV---------------KLTLV---VVACYIVCWTPFFVVQMWAAW 224
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 306 GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15196   225 DPTAPIEGPAFVIIMLLASLNSCTNPWIY 253
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
78-334 2.55e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 57.44  E-value: 2.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAHRWlFGWEGCQFYGWAGFFFGC--GSLITMTMV 155
Cdd:cd14964    15 GNLLVLLSLVRLRKRPRSTRLLLASLAACDL-LASLVVLVLFFLLGLTEA-SSRPQALCYLIYLLWYGAnlASIWTTLVL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGnYAPEPFGTSCTLDWWLAQASLSgqtfvMAILFF 234
Cdd:cd14964    93 TYHRYFALCGpLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKG-AIPRYNTLTGSCYLICTTIYLT-----WGFLLV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYvmiIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIP 314
Cdd:cd14964   167 SFLLPLVAFLVIF---SRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNL 243
                         250       260
                  ....*....|....*....|
gi 2116730773 315 VSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14964   244 LSILANLLAVLASTLNPFIY 263
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
64-334 3.44e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 57.55  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMsatGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFF 143
Cdd:cd15403     6 VMILMIAIGFL---GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLKIchLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLS 223
Cdd:cd15403    83 FVLEGVAILLIISVDRFLII--VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARAPQCVLGYTESPADRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFcliLPTGIIVFSYVMIIFKVKSSTKEV-SHFDAR------------INNSH--NLEMKLTKVA----ML 284
Cdd:cd15403   161 YAVLLVVAVFF---VPFSIMLYSYLCILNTVRRNAVRIhNHADSLclsqvsklglmgLQRPHqmNVDMSFKTRAfttiLI 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 285 ICAGFLIAWIPYAVVSVVSAFGEP---DSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15403   238 LFVGFSLCWLPHTVFSLLSVFSRRfyySSSFYPISTCVLWLSYLKSVFNPVIY 290
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
73-334 3.83e-09

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 57.36  E-value: 3.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15312    12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA------TMPLIGWGNYapepfgtsctldwwLAQASLSGQ 225
Cdd:cd15312    92 CFIAVDRYYAVCDpLHYRTKITTPVIKVFLVISWSVPCLFAfgvvfsEVNLEGIEDY--------------VALVSCTGS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVM------AILFF-CLILPTGIIVFSYVMIIF------KVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIA 292
Cdd:cd15312   158 CVLIfnklwgVIASLiAFFIPGTVMIGIYIKIFFvarkhaKVINNRPSVTKGDSKNKLSKKKERKAAKTLSIVMGVFLLC 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 293 WIPYAVVSVVSAFGEpDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15312   238 WLPFFVATLIDPFLN-FSTPVDLFDALVWLGYFNSTCNPLIY 278
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
63-334 3.99e-09

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 57.13  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  63 GVRLLDLSVgIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGkPFFIVSSFAHRWLFGWEGCQFYGWAGF 142
Cdd:cd15121     3 GIAILSLAF-ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTA-PFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCGSLITMTMVSLDRYLKICH------LRYGTWLKRhhaflCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWW 216
Cdd:cd15121    81 VSMYASIFLITLMSMDRCLAVAKpflsqkMRTKRSVRA-----LLLAIWI-VAFLLSLPMPFYRTVLKKNINMKLCIPYH 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 217 LAQASLSGQTFVMAILFFclILPTGIIVFSYVMIIFKVKSstkevshfdARINNSHnlemKLTKVAMLICAGFLIAWIPY 296
Cdd:cd15121   155 PSVGHEAFQYLFETITGF--LLPFTAIVTCYSTIGRRLRS---------ARFRRKR----RTNRLVVLIIATFALFWLPY 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2116730773 297 AVVSVVSAFGEPDSVPIPVSV---------VPTLLAKSSAMYNPIIY 334
Cdd:cd15121   220 HVVNLIQVAGALQNQAGNASVlkaaklarpNVTALAFLSSSVNPVLY 266
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
73-334 5.34e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 56.46  E-value: 5.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15327    12 LMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNyAPEPFGTSCTLDWWLAQASLSGqtfvmai 231
Cdd:cd15327    92 CVISVDRYVGVKHsLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKE-PPPPDESICSITEEPGYALFSS------- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 lFFCLILPTGIIVFSYVMI-IFKVKSSTkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS 310
Cdd:cd15327   164 -LFSFYLPLMVILVMYFRVyVVALKFSR----------------EKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALK 226
                         250       260
                  ....*....|....*....|....
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15327   227 PSEMVFKVIFWLGYFNSCVNPIIY 250
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
73-336 5.92e-09

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 56.79  E-value: 5.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15316    12 VLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWaTMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMaI 231
Cdd:cd15316    92 CFISVDRYIAVTDpLVYPTKFTVSVSGICISVSWIFSLTY-SFSVFYTGVNDDGLEELVNALNCVGGCQIILNQNWVL-V 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHN--------LEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15316   170 DFLLFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSEsykdrvarRERKAAKTLGITVIAFLVSWLPYLIDVLID 249
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 304 AFGEPDSVPIPVSVVPTLLAKSSAMyNPIIYQV 336
Cdd:cd15316   250 AFMNFITPPYIYEICCWCAYYNSAM-NPLIYAL 281
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
103-334 7.68e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 56.10  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 103 LAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCL 181
Cdd:cd15314    42 LAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQpLLYRSKITVRVVLVMI 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 182 VFVWVYAAFWA-TMPL----IGWGNYAPEPFGTSCTLDwwlaQASLSGqtFVMAILFFclILPTGIIVFSYvMIIFKV-- 254
Cdd:cd15314   122 LISWSVSALVGfGIIFlelnIKGIYYNHVACEGGCLVF----FSKVSS--VVGSVFSF--YIPAVIMLCIY-LKIFLVaq 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 255 KSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGepdSVPIPVSVVPTL--LAKSSAMYNPI 332
Cdd:cd15314   193 RQARSIQSARTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDPFI---NYSIPPVLIEVLnwLGYSNSTLNPF 269

                  ..
gi 2116730773 333 IY 334
Cdd:cd15314   270 IY 271
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
62-334 7.79e-09

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 56.37  E-value: 7.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  62 SGVRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAG 141
Cdd:cd15391     1 PHLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVfVWVYAAFWATMPLI-------GWGNyapePFGTSCTLD 214
Cdd:cd15391    81 LVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIAS-IWAISFSLSSVQLFagrtqryGQYS----EGRVLCGES 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 WWLAQASLSGQTFVMAILFFclILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWI 294
Cdd:cd15391   156 WPGPDTSRSAYTVFVMLLTY--IIPLLILTSTYGYVGFRLWNRTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWL 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2116730773 295 PYAVVSVVSAF-----GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15391   234 PLHLFNLVQDFstvfrNMPQHTTRLIYGACHWIAMSNSFVNPIIY 278
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
64-334 8.02e-09

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 56.00  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTI-KRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR------WLFGWEGCQf 136
Cdd:cd15341     3 IAVLCTLCGLLCILENVAVLYLILsSPKLRRKPSYLFIGSLALADFLASVVFACSFVDFHVFHGvdssaiFLLKLGGVT- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 137 ygwAGFFFGCGSLITMtmvSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYapePFGTSCT-LD 214
Cdd:cd15341    82 ---MSFTASLGSLLLM---AFDRYVCIYYpSEYKALVTRKRALVALAVMWVLTALIAYLPLMGWNCC---PLNSPCSeLF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 WWLAQASLSGQTFVMAILFFClilptgiIVFSYVMIIFKVKSSTKEVSHFDARI---NNSHNLEMKLTKVAMLICAGFLI 291
Cdd:cd15341   153 PLIPNDYLLSWLLLVAILLSG-------IIYTYGHVLWKAHKHVVYMEKHQDQQgpgNARMRLDVRLAKTLGLVLAVLLI 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2116730773 292 AWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15341   226 CWSPVLALMMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIY 268
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
71-262 8.80e-09

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 55.92  E-value: 8.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSF-AHRWLFGWEGCQFYgwAGFFFG--CG 147
Cdd:cd15162    10 VFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADL-LLVIWLPFKIAYHIhGNNWIFGEALCRLV--TVAFYGnmYC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGN--YAPEPFGTSC--TLDWWLAQASL 222
Cdd:cd15162    87 SILLLTCISIDRYLAIVHpMGHRRLRARRYALGTCLAIWLL-ALLVTLPLYLVKQtiFLPALDITTChdVLPEQLLVGDW 165
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2116730773 223 sgQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVS 262
Cdd:cd15162   166 --FYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENS 203
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
66-334 8.90e-09

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 56.09  E-value: 8.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSAT---GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGF 142
Cdd:cd16003     2 LWSLAYGFVVAVavfGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCGSLITMTMVSLDRYLKICHlRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTLDWWLAQASL 222
Cdd:cd16003    82 TSVFASIYSMTAIAVDRYMAIID-PLKPRLSATATKVVIGSIWILAFLLA-FPQCLYSKTKVMPGRTLCFVAWPGGPDQH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 223 SGQTFVMAILFFCLILPTGIIVFSYVMIIF---KVKSSTKEVSHFDARInnshnlEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd16003   160 FTYHIIVIVLVYCLPLLVMGITYTIVGITLwggEIPGDTSDKYHEQLRA------KRKVVKMMIIVVLTFAICWLPYHIY 233
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2116730773 300 SVVSAFGEPDS---VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd16003   234 FIVTGLYQQLNrwkYIQQVYLASFWLAMSSTMYNPIIY 271
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
64-334 9.31e-09

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 55.73  E-value: 9.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSAT--GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFA-HRWLFGWEGCQFygWA 140
Cdd:cd15328     1 VLVLTLLAMLVVATflWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgRRWQLGRSLCQV--WI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 141 GFFFGC--GSLITMTMVSLDRYLKIC-HLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLI-GWGN-YAPEpfgtsctldw 215
Cdd:cd15328    79 SFDVLCctASIWNVTAIALDRYWSITrHLEYTLRTRRRISNVMIALTWALSAVISLAPLLfGWGEtYSED---------- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 216 wLAQASLSGQ-TFVMAILFFCLILPTGIIVFSYVMIifkVKSSTKEvshfdarinnshnlEMKLTKVAMLICAgFLIAWI 294
Cdd:cd15328   149 -SEECQVSQEpSYTVFSTFGAFYLPLCVVLFVYWKI---YKAAQKE--------------KRAALMVGILIGV-FVLCWI 209
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 295 PYAVVSVVSAFGEPDSVPIPVSVVpTLLAKSSAMYNPIIY 334
Cdd:cd15328   210 PFFLTELISPLCSCDIPPIWKSIF-LWLGYSNSFFNPLIY 248
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
66-355 9.58e-09

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 56.11  E-value: 9.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFG 145
Cdd:cd15307     5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWgnYAPEPfgtSCTLDWWLAQASLSG 224
Cdd:cd15307    85 TASIMHLCTISVDRYLSLRYpMRFGRNKTRRRVTLKIVFVWLL-SIAMSLPLSLM--YSKDH---ASVLVNGTCQIPDPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAILffCLILPTGIIVFSYVMiifkvksSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15307   159 YKLVGSIV--CFYIPLGVMLLTYCL-------TVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPT 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 305 FGEPDSVPIPVSV--VPTLLAKSSAMYNPIIYQVVdlkNSCAKSSCFKVLKKR 355
Cdd:cd15307   230 VCAECEERISHWVfdVVTWLGYASSMVNPIFYTIF---NKVFRQAFKKVLLCR 279
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
70-334 1.04e-08

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 55.51  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  70 SVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15050     9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWaTMPLIGWGNYAPEpfGTSCTLDwwlaqaSLSGQTFV 228
Cdd:cd15050    89 FSLFILCIDRYRSVQQpLKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFARG--GERVVLE------DKCETDFH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 229 MAILFFCLilpTGIIVFSYVMIIFKVksstkevshFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGeP 308
Cdd:cd15050   160 DVTWFKVL---TAILNFYIPSLLMLW---------FYAKIFKAVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFC-K 226
                         250       260
                  ....*....|....*....|....*.
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15050   227 NCCNENLHMFTIWLGYINSTLNPFIY 252
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
71-334 1.38e-08

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 55.55  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd14971    10 IFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLK-RHHAFLCLVFVWVYAAFWATMPLIGWG--NYAPEPFgTSCTLDWWLAQASLSgqtF 227
Cdd:cd14971    90 TLVAMSLDRFLAVVYPLRSLHIRtPRNALAASGCIWVVSLAVAAPVLALHRlrNYTPGNR-TVCSEAWPSRAHRRA---F 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd14971   166 ALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRP----VLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGP 241
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 308 PDSVPIPVS--VVPTLLAKSSAMYNPIIY 334
Cdd:cd14971   242 FPLTYATYAlrIWAHCLAYSNSAVNPVLY 270
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
78-338 1.60e-08

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 54.95  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15322    17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICHLRYGTWLKRHHAFLCLVF-VWVYAAFWATMPLIGWGNYAPEPFGTSCTLD---WWLAQASLSGqtfvmailF 233
Cdd:cd15322    97 DRYWSITQAIEYNLKRTPRRIKCIIFiVWVISAVISFPPLITIEKKSGQPEGPICKINdekWYIISSCIGS--------F 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FcliLPTGIIVFSYVMIIFKVKsstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPdSVPI 313
Cdd:cd15322   169 F---APCLIMVLVYIRIYQIAK-----------------NREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDC-SVPE 227
                         250       260
                  ....*....|....*....|....*
gi 2116730773 314 PVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15322   228 TLFKFFFWFGYCNSSLNPVIYTIFN 252
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
71-338 1.73e-08

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 55.34  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYmTIKRKTKLKPP-ELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15089    10 VCVVGLLGNVLVMY-GIVRYTKMKTAtNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH----LRYGTWLKRHHAFLClvfVWVYAAFWATMPLIGWGNYAPEPFGTSCTL-----DWWLAQA 220
Cdd:cd15089    88 FTLTMMSVDRYIAVCHpvkaLDFRTPAKAKLINIC---IWVLSSGVGVPIMVMAVTKTPRDGAVVCMLqfpspSWYWDTV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SlsgqtfVMAILFFCLILPTGIIVFSYVMIIFKVKSstkeVSHFDARINNSHNLEmKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd15089   165 T------KICVFIFAFVVPILVITVCYGLMILRLRS----VRLLSGSKEKDRNLR-RITRMVLVVVAAFIICWTPIHIFV 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 301 VVSAFGEPDSV-PIPVSVVPTLLA--KSSAMYNPIIYQVVD 338
Cdd:cd15089   234 IVWTLVDIDRRnPLVVAALHLCIAlgYANSSLNPVLYAFLD 274
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
148-334 1.83e-08

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 55.24  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLR--YGTWLKRHHAFLCLVFVWVYAaFWATMPLIGWGNYAPEPfgTSCTLDWWLAQASLSGQ 225
Cdd:cd15211    85 SLLSHSLIALNRYVLITKLPavYQALYQKRNTEWMIALSWALA-LGLLLPWLTSFRYPTKS--CHDSADGSFAVVSVLSS 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINN----SHNLEMKLTKVAMLI-CAGFLIAWIPYAVVS 300
Cdd:cd15211   162 RYPALLLAFTVLGQTALVLHCYFGIFRRVQISVKRVSVLNFQIVNnlpySRPRKDKRLGLYVLLvCCVFLLTTEPLVWVS 241
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2116730773 301 VVSAFgepdsVPIPVSVVPT--LLAKSSAMYNPIIY 334
Cdd:cd15211   242 LAGLF-----VPVPVALQTAswLLFCTLFVLNPFLY 272
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
64-334 2.80e-08

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 54.46  E-value: 2.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTI-KRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR------WLFGWEGCQf 136
Cdd:cd15099     3 IAVLCFLAGPVTFLENILVLLTILsSTALRRRPSYLFIGSLALADMLASVIFTISFLDFHVFHQrdsrnlFLFKLGGVT- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 137 ygwAGFFFGCGSLItmtMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyAPEPFGTSCT-LD 214
Cdd:cd15099    82 ---MAFTASVGSLL---LTALDRYLCIYQpSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGW---RCKTWDSPCSrLF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 WWLAQASLSGQTFVMAILFFclilptgIIVFSYVMIIFKVKS---STKEVSHFDARINNSHNLEM--KLTKVAMLICAGF 289
Cdd:cd15099   153 PYIDRHYLASWTGLQLVLLF-------LIIYAYPYILWKAHRheaNMGGPKLGRQQVKGQARMRMdiRLAKTLSLILLVL 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2116730773 290 LIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15099   226 AICWLPVLAFMLVDVRVTLTNKQKRMFAFCSMLCLVNSCVNPIIY 270
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
64-358 3.18e-08

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 54.48  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgkPFFIVS------SFAHRWLFGWE---GC 134
Cdd:cd15360     3 LRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIY--LLLIASvdirtkSQYYNYAIDWQtgaGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 135 QFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTL 213
Cdd:cd15360    81 AAAGFFTVFASELSVYTLTVITLERWHTITYaMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 214 DWWLAQAslsgqtFVMAILFFClILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNshnlemkltKVAMLICAGFLiAW 293
Cdd:cd15360   161 ESPLSQA------YIIFILVLN-VLAFLIICACYIKIYLTVRNPNFVSSNSDTKIAK---------RMAVLIFTDFL-CM 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 294 IPYAVVSVVSAFGEPdsvPIPVSVVPTLLakssAMYNPIiyqvvdlkNSCAKSSCFKVLKK--RRHF 358
Cdd:cd15360   224 APISFFAISASLKVP---LITVSKSKILL----VLFYPI--------NSCANPFLYAIFTKtfRRDF 275
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
63-333 3.33e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 54.77  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  63 GVRLLDLSVGI-MSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVS-SFAHRWLFGWEGCQFYGWA 140
Cdd:cd15005     1 ALKLTTLGLILcVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASvRHGSGWIYGALSCKVIAFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 141 GFFFGCGSLITMTMVSLDRYLKICHLR-YGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYA--PE---------PFG 208
Cdd:cd15005    81 AVLFCFHSAFTLFCIAVTRYMAIAHHRfYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTfiREedqctfehrSYK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 209 TSCTLDWWLAQASLSGQTFVMAILFFCLI------------------------------------LPTGIIVFSYVMIIF 252
Cdd:cd15005   161 ANDTLGFMLVLAVVIAATHLVYLKLLIFLrhhrkmkpaqlvpaisqnwtfhgpgatgqaaanwtaGFGRGPTPPTLLGIR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 253 KVKSSTKEVSHFDARinnsHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPI 332
Cdd:cd15005   241 QAFHSGARRLLVLDE----FKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYAVPQGFLTAAVWMTFAQAGVNPI 316

                  .
gi 2116730773 333 I 333
Cdd:cd15005   317 V 317
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
73-334 3.68e-08

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 54.40  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15205    12 VLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAA-----FWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQT 226
Cdd:cd15205    92 TCIAVERHQGIVHpLKMKWQYTNRRAFTMLGLVWIVSVivgspMLFVQQLEVKYDFLYEKRHVCCLERWYSPTQQKIYTT 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFfclILPTGIIVFSYVMIIFKV----KSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIA--WIPYAVVS 300
Cdd:cd15205   172 FILVILF---LLPLTTMLFLYSRIGYELwikkRVGDASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAvcWAPFHVVH 248
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 301 VVSAF----GEPDSVPIPVSV-VPTLLAKSSAMYNPIIY 334
Cdd:cd15205   249 MMIEYsnleNKYDGVTIKLIFaIVQLIGFSNSFNNPIVY 287
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
73-334 3.90e-08

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 54.11  E-value: 3.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGCG---SL 149
Cdd:cd15978    12 LLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKT---ATYFMGISvsvST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAP-----EPFGTSCTLDWWLAQASLS 223
Cdd:cd15978    89 FNLVAISLERYSAICKpLKSRVWQTKSHALKVIAATWCL-SFTIMLPYPIYSNLVPftrinNSTGNMCRLLWPNDVTQQS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFfclILPTGIIVFSYVMIIFKVKSSTKEVShfdarinnshnLEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15978   168 WYIFLLLILF---LIPGIVMMTAYGLISLELYRGIKFLM-----------AKKRVIRMLIVIVILFFLCWTPIFSANAWR 233
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 304 AFgEPDSVPIPVSVVPT----LLAKSSAMYNPIIY 334
Cdd:cd15978   234 AF-DTRSADRLLSGAPIsfihLLSYTSACVNPIIY 267
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
69-334 4.60e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 54.14  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKP-PELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd15959     7 LSLAILVIVGGNLLVIVAIAKTPRLQTmTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIG-WGNYAPEPFGTSCTLDWWLAqASLSGQ 225
Cdd:cd15959    87 SIETLCAIAVDRYLAITNpLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqWWRDGADEEAQRCYDNPRCC-DFVTNM 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAILFFCLILPTGIIVFSYVMIIF----KVKSSTKEVSHFD-----------ARINNSHNL----EMKLTKVAMLIC 286
Cdd:cd15959   166 PYAIVSSTVSFYVPLLVMIFVYVRVFVvatrQVRLIRKDKVRFPpeesppaesrpACGRRPSRLlaikEHKALKTLGIIM 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2116730773 287 AGFLIAWIPYAVVSVVSAFGePDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15959   246 GTFTLCWLPFFVANIIKVFC-RSLVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
73-298 5.40e-08

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 53.56  E-value: 5.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGIsVTGKPFFIVSSFA-HRWLFGWEGCQFygwAGFFFGCG---S 148
Cdd:cd15161    12 ILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYHLSgNHWPFGEVPCRL---AGFLFYLNmyaS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGwGNYAPEPFGTSCTLDWWLAQASlsgqTF 227
Cdd:cd15161    88 LYFLACISVDRFLAIVHpVKSMKIRKPLYAHVVCGFLWVIVTV-AMAPLLV-SPQTVEVNNTTVCLQLYREKAS----RG 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnLEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15161   162 ALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKP----------LKDKAIKMIILVLTIFLICFVPYHI 222
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
75-334 5.58e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 53.50  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  75 SATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:cd15389    14 SLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRygTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTLDWWLA---QASLSGQTFVMA 230
Cdd:cd15389    94 IALDRHRVILHpLK--PRITPCQGVVVIAIIWIMASCLS-LPHAIYQKLVEFEYSNERTRSRCLPsfpEPSDLFWKYLDL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCL-ILPTGIIVFSYVMIIFK------VKSSTKE--VSHFDARinnshnleMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15389   171 ATFILQyVLPLLIIGVAYTRVAKKlwlrnaIGDVTTEqyVAQRRKK--------KKTIKMLMLVVLLFAICWLPLNCYHV 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 302 VSAFgEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15389   243 LLSS-HPIRSNSALFFAFHWLAMSSTCYNPFIY 274
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
66-334 6.16e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 53.40  E-value: 6.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAhrWLFGWEGCQFYGWAGFFFG 145
Cdd:cd15068     5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFIACFVLVLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CGSLITMTMVSLDRYLKI-CHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAP----EPFGTSCT--LDWWLA 218
Cdd:cd15068    83 QSSIFSLLAIAIDRYIAIrIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQpkegKNHSQGCGegQVACLF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 QASLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSH---FDARINNSHNLEMKLTKVAMLICAGFLIAWIP 295
Cdd:cd15068   163 EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESqplPGERARSTLQKEVHAAKSLAIIVGLFALCWLP 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 296 YAVVSVVSAF-GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15068   243 LHIINCFTFFcPDCSHAPLWLMYLAIVLSHTNSVVNPFIY 282
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
64-334 6.22e-08

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 53.28  E-value: 6.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSV-GIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGF 142
Cdd:cd15979     2 VRILLYSViFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKA---VAY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCG---SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWV--------YAAFWATMPLigwgNYAPEPFGTS 210
Cdd:cd15979    79 LMGVSvsvSTFSLVAIAIERYSAICNpLQSRVWQTRSHAYRVIAATWLlsglimipYPVYSVTVPV----PVGDRPRGHQ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 211 CTLDWWLAQASLSGQTFVMAILFFcliLPTGIIVFSYVMIifkvkssTKEVshFDARINNSHNLEMKLTKVAMlicagFL 290
Cdd:cd15979   155 CRHAWPSAQVRQAWYVLLLLILFF---IPGVVMIVAYGLI-------SREL--YRGLLAKKRVIRMLVVIVAM-----FF 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2116730773 291 IAWIPYAVVSVVSAFGEPDS----VPIPVSVVpTLLAKSSAMYNPIIY 334
Cdd:cd15979   218 LCWLPIFSANTWRAFDPLSAhralSGAPISFI-HLLSYTSACVNPLVY 264
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
73-298 6.31e-08

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 53.51  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFD--FGISVTGKPFFIVSSFAhrWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15159    12 VFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDilFTLALPGRIAYYALGFD--WPFGDWLCRLTALLFYINTYAGVN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAPEPFGTSCtldwwLAQASLSGqTFVM 229
Cdd:cd15159    90 FMTCLSVDRYIAVVHpLRRHRLRKVKVVRYICVFVWVL-VFLQTLPLLFMPMTKEMGGRITC-----MEYPNFEK-IKRL 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116730773 230 A--ILFFCLI---LPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15159   163 PliLLGACVIgfgVPVGIILFCYSQITLKLCRTAKENPLTEKSGHHK-----KACNVILLVLLVFVVCFSPYHL 231
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
73-334 1.12e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 52.49  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15062    12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFgTSCTLDWWLAQASLSgqtfvmAI 231
Cdd:cd15062    92 CVISVDRYIGVRYpLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADE-QACGVNEEPGYVLFS------SL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 LFFclILPTGIIVFSYVMIIfkvksstkevshfdaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSV 311
Cdd:cd15062   165 GSF--YLPLAIILVMYCRVY---------------VVAFKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKP 227
                         250       260
                  ....*....|....*....|...
gi 2116730773 312 PIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15062   228 PEPVFKVVFWLGYFNSCLNPIIY 250
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
78-334 1.18e-07

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 52.28  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFI-VSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15310    17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKIC---HLRYGT-WLKRHHAFLCLVFVWVYAaFWATMPLIgwgnyapepFGTSCTLDwwLAQASLSGQTFVMAIL 232
Cdd:cd15310    97 IDRYTAVVmpvHYQHGTgQSSCRRVSLMITAVWVLA-FAVSCPLL---------FGFNTTGD--PTVCSISNPDFVIYSS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFCLILPTGIIVFSYVMI-IFKVKsstkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSV 311
Cdd:cd15310   165 VVSFYLPFGVTLLVYVRIyVVLLR-------------------EKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHV 225
                         250       260
                  ....*....|....*....|...
gi 2116730773 312 PIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15310   226 PPELYSATTWLGYVNSALNPVIY 248
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
78-334 1.23e-07

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 52.55  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15318    17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLigWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFCL 236
Cdd:cd15318    97 DRHCAICDpLLYPSKFTIRVACIFIAAGWLVPTVYTSVFL--YTKAVEEGLAELLTSVPCVGSCQLLYNKLWGWLNFPVF 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 237 ILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVS 316
Cdd:cd15318   175 FIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPLLFD 254
                         250
                  ....*....|....*...
gi 2116730773 317 VVPTLLAKSSAMyNPIIY 334
Cdd:cd15318   255 IIIWFAYFNSAC-NPLIY 271
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
102-340 1.51e-07

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 52.33  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPF-FIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFL 179
Cdd:cd15134    41 SLAVSDLLLLILGLPFeLYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHpLRSHTMSKLSRAIR 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 180 CLVFVWVyAAFWATMPLIGWG--NYAPEPFGTSCTLDwWLAQASLSGQTFVMAILF---FCL--ILPTGIIVFSYVMIIF 252
Cdd:cd15134   121 IIIAIWI-IAFVCALPFAIQTriVYLEYPPTSGEALE-ESAFCAMLNEIPPITPVFqlsTFLffIIPMIAIIVLYVLIGL 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 253 KVKSST----KEVSHFDARINNSHNLEMKLTKVAMLICagFLIAWIPYAVVSVVSAFGePDSVPIPVSVVPTLLAKSSAM 328
Cdd:cd15134   199 QLRRSTllrrGQRSVSGGRRSSQSRRTVLRMLVAVVVA--FFICWAPFHAQRLLTVYA-KNMTPPYLFINRILFYISGVL 275
                         250
                  ....*....|....*...
gi 2116730773 329 Y------NPIIYQVVDLK 340
Cdd:cd15134   276 YyvsstvNPILYNVMSAK 293
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
78-302 1.91e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 52.12  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYmTIKRKTKLKP----PELMTVNLAIFDFgISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15338    17 GNSIVIY-TIVKKSKFRCqqtvPDIFIFNLSIVDL-LFLLGMPFLIHQLLGNgVWHFGETMCTLITALDTNSQITSTYIL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAaFWATMPLIGWGNYAPEPFGT-SCTLdwWLAQASLSGQTFVMA 230
Cdd:cd15338    95 TVMTLDRYLATVHpIRSTKIRTPRVAVAVICLVWILS-LLSITPVWMYAGLMPLPDGSvGCAL--LLPNPETDTYWFTLY 171
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15338   172 QFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTK-----KVTRMAVAICLAFFICWAPFYILQLA 238
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
101-334 2.45e-07

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 51.62  E-value: 2.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 101 VNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRhhAFL 179
Cdd:cd15208    40 VNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHpLMFKSTAKR--ARV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 180 CLVFVWVYAAFWA--------TMPLIGWGNYApePFGTSCTLDWWLAQASLSGQTFVMAILFFcliLPTGIIVFSYVMII 251
Cdd:cd15208   118 SILIIWIVSLLIMipqaivmeCSRVVPLANKT--ILLTVCDERWSDSIYQKVYHICFFLVTYL---LPLCLMILAYFQIF 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 252 FKV-------KSSTKEVSHFDARINNSHNLEMKLT---KVA-MLIC--AGFLIAWIPYAVVSV---VSAF--GEPDSVPI 313
Cdd:cd15208   193 RKLwcrqipgTSSVVQRKWNKPRKSAVAAEEKQLRsrrKTAkMLIVvvIMFAICYLPVHLLNIlryVFGLftVDRETIYA 272
                         250       260
                  ....*....|....*....|.
gi 2116730773 314 PVSVVPTLLAKSSAMyNPIIY 334
Cdd:cd15208   273 WFLFSHWLVYANSAI-NPIIY 292
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
73-302 2.47e-07

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 51.67  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFAHrWLFGWEGCQFYGWAGFF-FGCGSLIt 151
Cdd:cd15181    12 LLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIAG-WVFGTFLCKLVGAIHKLnFYCSSLL- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICHLRYGTWLKRHHA--FLCLVfVWVyAAFWATMPLIGWGNY--APEPFGTSCTL--------DWWLAq 219
Cdd:cd15181    89 LACISVDRYLAIVHAIHSYRHRRLRSvhLTCGS-IWL-VCFLLSLPNLVFLEVetSTNANRTSCSFhqygihesNWWLT- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 aslsgQTFVMAILFFclILPTGIIVFSYVMIIFKVKSStkevshfdarinnSHNLE-MKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15181   166 -----SRFLYHVVGF--FLPLLIMGYCYATIVVTLCQS-------------SRRLQkQKAIRVAILVTLVFCLCWLPYNI 225

                  ....
gi 2116730773 299 VSVV 302
Cdd:cd15181   226 VIFL 229
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
73-301 2.57e-07

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 51.60  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIY-MTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15383    12 VLSACSNLAVLWsATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVfvWVYAAFWATMPLIGWGN---YAPEPFgTSCTLDWWLaQASLSGQTF 227
Cdd:cd15383    92 TVVISLDRHAAILNpLAIGSARRRNRIMLCAA--WGLSALLALPQLFLFHTvtaTPPVNF-TQCATHGSF-PAHWQETLY 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMaILFFCL-ILPTGIIVFSYVMIIFKVKS---STKEVSHFDARINNSHNL----EMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15383   168 NM-FTFFCLfLLPLLIMIFCYTRILLEISRrmkEKKDSAKNEVALRSSSDNipkaRMRTLKMTIVIVSSFIVCWTPYYLL 246

                  ..
gi 2116730773 300 SV 301
Cdd:cd15383   247 GL 248
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
73-337 3.21e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 51.40  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFA-HRWLFGWEGCQFYGwAGFFFGC-GSLI 150
Cdd:cd15357    12 VVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSnYPFLFGPVGCYFKT-ALFETVCfASIL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWG---NYAPE----PFGTSCTL--DWWLAQA 220
Cdd:cd15357    91 SVTTVSVERYVAILHpFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGiklQYFPNgtliPDSATCTVvkPLWIYNL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SLSgqtfVMAILFFclILPTGIIVFSYVMIIFKVKSStKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd15357   171 IIQ----ITSLLFY--VLPMGVISVLYYLMGLKLRGD-KSLEADEMNVNIQRPSRKSVTKMLFVLVLVFAICWAPFHVDR 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 301 VVSAFGEPDSVPIP-----VSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15357   244 LFFSFVVEWTEPLAnvfnlIHVVSGVFFYLSSAVNPIIYNLL 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
71-334 3.33e-07

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 51.30  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTiKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15116    10 VFVLGVLGNGLVIFIT-GFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNMFTSVF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKIChlrYGTWLKRHH----AFLCLVFVWVYAAFWATMPLIgWGNYAPEPFG--TSCTLDW--------- 215
Cdd:cd15116    89 LLTVISIDRCISVV---FPVWSQNHRsvrlASLVSLAVWVVAFFLSSPSFI-FRDTAPSQNNnkIICFNNFslsgdnssp 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 216 WLAQASLSGQTFVMAILFFC-LILPTGIIVFSYVMIIFKVKSStkevshfdaRINNSHnlemKLTKVAMLICAGFLIAWI 294
Cdd:cd15116   165 EVNQLRNMRHQVMTITRFLLgFLIPFTIIICCYAAIVLKLKRN---------RLAKSS----KPFKIIAAVIVTFFLCWA 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2116730773 295 PYAVVSVVSAFGEPD-----SVPIPVSvvpTLLAKSSAMYNPIIY 334
Cdd:cd15116   232 PYHILNLLEMEATRSpasvfKIGLPIT---SSLAFINSCLNPILY 273
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
80-354 3.60e-07

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 51.32  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  80 GYVIYMTIKRKTKLKPPELM-TVNLAIFDFgISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGCGSLITM---TMV 155
Cdd:PHA03087   57 GNIIVIYVLTKTKIKTPMDIyLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACKI---VSGLYYIGFYNSMnfiTVM 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGTWLK--RHHAFLCLVfVWVYAAFwATMPLIGWGNYAPE-------PFGTSCTLDWWLAqaslsgQT 226
Cdd:PHA03087  133 SVDRYIAIVHPVKSNKINtvKYGYIVSLV-IWIISII-ETTPILFVYTTKKDhetliccMFYNNKTMNWKLF------IN 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFclILPTGIIVFSYVMIIFKVKsstkevshfdaRINNSHNlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF- 305
Cdd:PHA03087  205 FEINIIGM--LIPLTILLYCYSKILITLK-----------GINKSKK-NKKAIKLVLIIVILFVIFWLPFNVSVFVYSLh 270
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 306 ------GEPDSVPIPVSV-VPTLLAKSSAMYNPIIYQVVDLKNSCAKSSCFKVLKK 354
Cdd:PHA03087  271 ilhfksGCKAVKYIQYALhVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFT 326
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
78-340 3.67e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.14  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR-WLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd14997    17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDWWLAQA-SLSGQTFVMAILFF 234
Cdd:cd14997    97 FERYYAICHpLQAKYVCTKRRALVIIALIWLLALL-TSSPVLFITEFKEEDFNDGTPVAVCRTPAdTFWKVAYILSTIVV 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 235 CLILPTGIIVFSYVMIIFK-VKSSTKEvsHFDARINNSHNLEMKLTKVAMLIC--AGFLIA---------WIPYAVVSVV 302
Cdd:cd14997   176 FFVVPLAILSGLYSVICRRlVGHPALE--SRRADAANRHTLRSRRQVVYMLITvvVLFFVCllpfrvvtlWIIFAPDEDL 253
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2116730773 303 SAFGePDSVPIPVSVVPTLLAKSSAMyNPIIYQVVDLK 340
Cdd:cd14997   254 QALG-LEGYLNLLVFCRVMVYLNSAL-NPILYNLMSTK 289
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
66-334 3.78e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 50.94  E-value: 3.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGImsaTGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGkPFFIVSSFAHRWLFGWEGCQfygwaGFFFG 145
Cdd:cd14975     8 SLAFAIGL---PGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTL-PVWIYFLATGTWDFGLAACK-----GCVYV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 146 CG-----SLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTL----DWW 216
Cdd:cd14975    79 CAvsmyaSVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYrhysDGQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 217 LAqaslsgqtfvmailfFCLILPTG--------IIVFSYVMIIFKVKSSTKEVSHFDARInnshnlemkltkVAMLICAg 288
Cdd:cd14975   159 LV---------------FHLLLETVvgfavpftAVVLCYSCLLRRLRRRRFRRRRRTGRL------------IASVVVA- 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 289 FLIAWIPYAVVSVVS----------AFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14975   211 FAACWLPYHVGNLLEvvseliggskMAGTLGKVAEAGRPIAGALAFLSSSINPLLY 266
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
64-336 4.31e-07

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 51.02  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGI--------SVTGKPFFIVSSFAHRWLFGwEGCQ 135
Cdd:cd15359     3 LRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMglyllliaSVDSQTKSQYYNHAIDWQTG-SGCS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 136 FYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLD 214
Cdd:cd15359    82 TAGFFTVFASELSVYTLTVITLERWHTITYaMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 WWLAQAslsgqtFVMAILFFCLILPTgIIVFSYVMIIFKVKSSTKEVSHFDARINNshnlemkltKVAMLICAGFlIAWI 294
Cdd:cd15359   162 TLLSQA------YILLILVLNVIAFL-VICACYIKIYLAVQNPELVAKNKDTKIAK---------RMAILIFTDF-TCMA 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 295 PYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15359   225 PISFFAISAAFKVPLITVTNSKILLVLFYPINSCANPFLYAI 266
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
71-334 4.50e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 50.93  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRwlFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15070    10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVT--IHFYSCLFMSCLLVVFTHASIM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKI-CHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAqaSLSGQTFVM 229
Cdd:cd15070    88 SLLAIAVDRYLRVkLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFT--SVMRMDYMV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLIL-PTGIIVFSYVMIIFKVK-------SSTKEVSHFDARinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15070   166 YFSFFTWILiPLVIMCALYVDIFYIIRnklsqnaTGFRETGAFYGR-------EFKTAKSLALVLFLFAVCWLPLSIINC 238
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 302 VSAFGEpdSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15070   239 VVYFNP--KVPKIALYLGILLSHANSMMNPIVY 269
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
67-334 6.01e-07

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 50.51  E-value: 6.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  67 LDLSVGIMsatGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGwagfFFGC 146
Cdd:cd15397     9 LVMAVGLL---GNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTP----FIQC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 G----SLITMTMVSLDRYLKICHlRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGT------------S 210
Cdd:cd15397    82 MsvtvSILSLVLIALERHQLIIN-PTGWKPSVSQAYLAVVVIWMLACF-ISLPFLAFHILTDEPYKNlshffapladkaV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 211 CTLDWWLAQASLSGQTFvmaILFFCLILPTGIIVFSYVMIIFKVKSSTKEVShfdaRINNSHNLEMKLTKVAML---ICA 287
Cdd:cd15397   160 CTESWPSEHHKLAYTTW---LLLFQYCLPLLFILVCYLRIYLRLRRRKDMLE----RRGEYNRRAGHSKRINVMlvsLVA 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116730773 288 GFLIAWIPYAVVSVVSAFgEPDSVPI----PVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15397   233 AFALCWLPLNVFNAIADW-NHEAIPHcqhnLIFSLCHLAAMASTCVNPIIY 282
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
64-334 7.13e-07

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 50.26  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYM-TIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIV-SSFAHRWLFGWEGCQFYGWAG 141
Cdd:cd15925     3 VALAYGLVCAIGLLGNLAVMYLlRNCARRAPPPIDVFVFNLALADFGFALT-LPFWAVeSALDFHWPFGGAMCKMVLTAT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSCTL----DWW 216
Cdd:cd15925    82 VLNVYASVFLLTAMSVTRYWVVASaAGPGTHLSTFWAKIITLALWA-AALLATVPTAIFATEGEVCGVELCLLkfpsNYW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 217 LAQASLsgQTFVMAilffcLILPTGIIVFSYVMIIFKVKSSTKEVSHFD--ARINNShnlemkltkvAMLICAGFLIAWI 294
Cdd:cd15925   161 LGAYHL--QRVVVA-----FVVPLGVITTSYLLLLSFLQQHKVNQNNRQrqSVIARS----------VRLVVASFFLCWF 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2116730773 295 PYAVVSVVSAFGEPDSVP-------IPVSVVP--TLLAKSSAMYNPIIY 334
Cdd:cd15925   224 PNHVVTFWGVLVKFRAVPwnstfyfIHTYVFPvtTCLAHSNSCLNPVLY 272
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
73-337 7.31e-07

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 50.15  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFF-IVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15381    12 VLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADL-LLVCCLPFWaINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH------LRYGTWLKrhhaFLCLVfVWVYaAFWATMPLIGWGN--YAPEPFGTSCTLDWwlaqASLS 223
Cdd:cd15381    91 LMMVSIDRYLALVKtmssgrMRRPACAK----LNCLI-IWMF-GLLMSTPMIVFRTvmYFPEYNITACVLDY----PSEG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFV-MAILFFCLILPTGIIVFSYVMIIFKVKSST----KEVshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15381   161 WHVALnILLNVVGFLIPLSIITFCSTQIIQVLRNNKmqkfKEI-----------QTERKATVLVLAVLLMFFICWLPFHI 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2116730773 299 VSVVSAFGEPDSVPIP--------VSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15381   230 FTFLDTLHKLGLISGCrwedildiGTQIATFLAYSNSCLNPLLYVIV 276
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
70-300 7.34e-07

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 50.16  E-value: 7.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  70 SVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFF---IVSSFahRWLFGWEGCQFYGWAGFFFGC 146
Cdd:cd15189     9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL-VFVSGLPFWamnILNQF--NWPFGELLCRVVNGVIKVNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 GSLITMTMVSLDRYLKICHLRYGTWLKR-HHAFLCLVFVWVYAAFWAT-MPLIGWGNYAPEPFGTSCTLD-----WWLAQ 219
Cdd:cd15189    86 TSIYLLVMISQDRYLALVKTMAARRLRRrRYAKLICVLIWVVGLLLSIpTFLLRKIKAIPDLNITACVLLypheaWHFAH 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 ASLsgqtfvMAILFFclILPTGIIVFSyVMIIFKVKSSTKEVSHFDARInnshnlEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15189   166 IVL------LNIVGF--LLPLLVITFC-NYNILQALRTREESTRCEDRN------DSKATALVLAVTLLFLVCWGPYHFF 230

                  .
gi 2116730773 300 S 300
Cdd:cd15189   231 T 231
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
69-334 8.06e-07

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 50.39  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSAT-GNGYVIYMTIK-RKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGwEGCQFygWAGFFFGC 146
Cdd:cd15320     8 LSVLILSTLlGNTLVCAAVIRfRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNI--WVAFDIMC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 --GSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPL-IGWGNYAPEPF--GTSCTLDWWLAQA 220
Cdd:cd15320    85 stASILNLCVISVDRYWAISSpFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKAKPTSFldLNASLRDLTMDNC 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SLS-GQTFVMAILFFCLILPTGIIVFSYVMI-------IFKVKSSTKEVSHFDARINNSHNL------------------ 274
Cdd:cd15320   165 DSSlNRTYAISSSLISFYIPVAIMIVTYTRIyriaqkqIRRISALERAAVHAKNCQNSTGNRgsgdcqqpessfkmsfkr 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 275 EMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTL-----LAKSSAMYNPIIY 334
Cdd:cd15320   245 ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTEPFCISSTTFdvfvwFGWANSSLNPIIY 309
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
71-307 8.48e-07

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 50.14  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKtKLKP-PELMTVNLAIFDFGISVTgKPFFIVSSfAHRWLFGWEGCQFYG---WAGFFFGC 146
Cdd:cd15184    10 VFIFGFVGNMLVVLILINCK-KLKSmTDIYLLNLAISDLLFLLT-LPFWAHYA-ANEWVFGNAMCKLLTglyHIGFFSGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 GSLITMTMvslDRYLKICHLRYGtwLKRH---HAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDWWLAQASLS 223
Cdd:cd15184    87 FFIILLTI---DRYLAIVHAVFA--LKARtvtFGVVTSVVTWVVAVF-ASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSstkevshfdARINNSHNLEMKLTKVAMLIcagFLIAWIPYAVVSVVS 303
Cdd:cd15184   161 KNFQTLKMNILGLVLPLLVMIICYSGILKTLLR---------CRNEKKRHKAVRLIFTIMIV---YFLFWAPYNIVLLLN 228

                  ....
gi 2116730773 304 AFGE 307
Cdd:cd15184   229 TFQE 232
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
78-340 8.48e-07

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 50.07  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSfAHRWLFGWEGCQFYGwAGFF--FGCGSLItMTMV 155
Cdd:cd15180    17 GNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVT-LPFWAVQA-VHGWIFGTGLCKLAG-AVFKinFYCGIFL-LACI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHlryGTWLKRHH----AFLCLVFVWVYAAFWATMPLIGWG-NYAPEPFGTSC-------TLDWWLAQasls 223
Cdd:cd15180    93 SFDRYLSIVH---AVQMYSRKkpmlVHLSCLIVWLFCLLLSIPDFIFLEaTKDPRQNKTECvhnfpqsDTYWWLAL---- 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 gqTFVMAILFFclILPTGIIVFSYVMIIFKVKSSTKEVShfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15180   166 --RLLYHIVGF--LLPLAVMVYCYTSILLRLLRSSQGFQ------------KQRAIRVIVAVVVVFFLCWTPYNIALLVD 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 304 AFGEP----DSVPIPVSVVPTLLAKSSAMY-----NPIIYQVVDLK 340
Cdd:cd15180   230 TLIDLsvldRNCGTESRLDIALSVTSSLGYfhcclNPLLYAFVGVK 275
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
78-334 8.93e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 50.14  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIyMTIKRKTKLKP-PELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15058    17 GNLLVI-IAIARTSRLQTmTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIgwgnyapepfgtsctLDWWLAQ--------------AS 221
Cdd:cd15058    96 VDRYIAITRpLRYQVLLTKRRARVIVCVVWIVSALVSFVPIM---------------NQWWRANdpeandcyqdptccDF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNL-----------------------EMKL 278
Cdd:cd15058   161 RTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKRRLRFQSECPApqttspegkrssgrrpsrltvvkEHKA 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 279 TKVAMLICAGFLIAWIPYAVVSVVSAFGePDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15058   241 LKTLGIIMGTFTLCWLPFFIANIINVFN-RNLPPGEVFLLLNWLGYINSGLNPIIY 295
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
71-259 9.52e-07

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 49.77  E-value: 9.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSF-AHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15368    10 VALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDL-MLACFLPFQIVYHIqRNHWIFGKPLCNVVTVLFYANMYSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWG-NYAPEPFG-TSC--TLDWWLAQASLSG 224
Cdd:cd15368    89 LTMTCISIERYLGVVYpMRSMRWRKKRYAVAACIGMWLLVLT-ALSPLERTDlTYYVKELNiTTCfdVLKWTMLPNIAAW 167
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2116730773 225 QTFVMAILFFCLILPTGIIVFSYVMIIFK-VKSSTK 259
Cdd:cd15368   168 AAFLFTLFILLFLIPFIITVYCYVLIILKlVQTSER 203
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
71-334 1.04e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 49.75  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRktkLKPPELMTV---NLAIFDFGISVTGkPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCG 147
Cdd:cd14999     9 MCVVGVAGNVYTLVVMCLS---MRPRASMYVyilNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKIchLRYGTWLKR--HHAFLCLVFVWVyAAFWATMPLIGW----GNYAPEPFGTSCTLDWWlaqaS 221
Cdd:cd14999    85 SIFTLTVMSTERYLAV--VKPLDTVKRskSYRKLLAGVIWL-LSLLLTLPMAIMirlvTVEDKSGGSKRICLPTW----S 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMAILFFCLIL-PTGIIVFSYVMIIFKVKSSTKEVSHFD-ARINNSHNLEMKLTKVAMlicagFLIAWIPYAVV 299
Cdd:cd14999   158 EESYKVYLTLLFSTSIViPGLVIGYLYIRLARKYWLSQAAASNSSrKRLPKQKVLKMIFTIVLV-----FWACFLPFWIW 232
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 300 SVVSAFGEPDSVP----IPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd14999   233 QLLYLYSPSLSLSprttTYVNYLLTCLTYSNSCINPFLY 271
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
73-338 1.09e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 49.55  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15323    12 VFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTL--DWWLAQASLSGQTFVm 229
Cdd:cd15323    92 CAISLDRYWSVTQaVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYPQCKLndETWYILSSCIGSFFA- 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 ailffclilPTGIIVFSYVMIIFKVKSSTKevshfdarinnshnlemKLTKVAMLICAGFLIAWIPYAV-VSVVSAFGEP 308
Cdd:cd15323   171 ---------PCLIMILVYIRIYRVAKAREK-----------------RFTFVLAVVMGVFVVCWFPFFFsYSLYGICREA 224
                         250       260       270
                  ....*....|....*....|....*....|
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15323   225 CEVPEPLFKFFFWIGYCNSSLNPVIYTIFN 254
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
66-334 1.27e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 49.55  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIyMTIKRKTKLK-PPELMTVNLAIFDFGISVTGKPFFIVSS-FAHRWLFGWEGCQFYGWAGFF 143
Cdd:cd15304     5 LLTVIVIILTIAGNILVI-MAVSLEKKLQnATNYFLMSLAIADMLLGFLVMPVSMLTIlYGYRWPLPSKLCAVWIYLDVL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLK----ICHLRYGTwlkRHHAFLCLVFVW-VYAAFWATMPLIGWGNYAPEPFGTSCtldwwla 218
Cdd:cd15304    84 FSTASIMHLCAISLDRYIAirnpIHHSRFNS---RTKAFLKIIAVWtISVGISMPIPVFGLQDDSKVFKEGSC------- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 qaSLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSStkevshfdarINNshnlEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15304   154 --LLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQS----------ISN----EQKASKVLGIVFFLFVVMWCPFFI 217
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 299 VSVVSAFGEPDSVPIPVSV---VPTLLAKSSAMYNPIIY 334
Cdd:cd15304   218 TNVMAVICKESCNEVVIGGllnVFVWIGYLSSAVNPLVY 256
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
71-302 1.47e-06

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 49.13  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGIsvtGKPFFIVSS-----------FAHRWLFGwEGCQFYGW 139
Cdd:cd15964    10 VNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCM---GIYLLLIASvdlhtrseyynHAIDWQTG-PGCNTAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPE----PFGTSCTLd 214
Cdd:cd15964    86 FTVFASELSVYTLTVITLERWYAITFaMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVsiclPMDTETPL- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 wwlaqaslsGQTFVMAILfFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNshnlemkltKVAMLICAGFL-IAW 293
Cdd:cd15964   165 ---------AQAYIVFVL-MLNIIAFVIICACYIKIYITVRNPQYKSGDKDTKIAK---------RMAVLIFTDFIcMAP 225

                  ....*....
gi 2116730773 294 IPYAVVSVV 302
Cdd:cd15964   226 ISFYALSAI 234
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
148-338 1.65e-06

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 49.05  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyapepfGTSCTLDWWLAQASLSGQTF 227
Cdd:cd15101    86 SVANLLAIAVERHISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGW--------NCLCAIDACSNMAPLYSRSY 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTgIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15101   158 LVFWAISNLVTFL-VMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLCC 236
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15101   237 RQCNVLAVEKFFLLLAEFNSAVNPIIYSYRD 267
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
71-336 1.67e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 48.79  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygWAGFFFGC--GS 148
Cdd:cd15334    10 LALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDI--WLSVDITCctCS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNyapepFGTSCTLDWWLAQASLsgqTF 227
Cdd:cd15334    88 ILHLSAIALDRYRAITDaVEYARKRTPKHAGIMIAVVWIISIF-ISMPPLFWRH-----QTTSREDECIIKHDHI---VF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGIIVFSYVMIifkVKSSTKevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15334   159 TIYSTFGAFYIPLALILILYYKI---YRAATR---------------ERKAATTLGLILGAFVICWLPFFVKEVIVNTCD 220
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15334   221 SCYISEEMSNFLTWLGYINSLINPLIYTI 249
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
66-303 1.78e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 49.13  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIyMTIKRKTKLK-PPELMTVNLAIFDFGISVTGKPFFIVSS-FAHRWLFGWEGCQFYGWAGFF 143
Cdd:cd15305     5 LLILIIIILTIGGNILVI-MAVSLEKKLQnATNFFLMSLAVADMLVGILVMPVSLIAIlYDYAWPLPRYLCPIWISLDVL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLKIC----HLRYGTwlkRHHAFLCLVFVWVYA-AFWATMPLIGWGNYAPEPFGTSCTLDwwla 218
Cdd:cd15305    84 FSTASIMHLCAISLDRYVAIRnpieHSRFNS---RTKAMMKIAAVWTISiGISMPIPVIGLQDDEKVFVNGTCVLN---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 qaslsGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKevshfdarINNshnlEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15305   157 -----DENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQA--------INN----ERRASKVLGIVFFLFLIMWCPFFI 219

                  ....*
gi 2116730773 299 VSVVS 303
Cdd:cd15305   220 TNILS 224
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-305 2.05e-06

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 48.90  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSsFAHRWLFGWEGCQFYGwAGFFFGC-GSLIT 151
Cdd:cd15182    12 LLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL-LFTFTLPFWASY-HSSGWIFGEILCKAVT-SIFYIGFySSILF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMP-LIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFvm 229
Cdd:cd15182    89 LTLMTIDRYLAVVHpLSALRSRKLRYASLVSVAVWV-ISILASLPeLILSTVMKSDEDGSLCEYSSIKWKLGYYYQQN-- 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2116730773 230 aiLFFclILPTGIIVFSYVMIIFKVksstkevshFDARINNSHnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15182   166 --LFF--LIPLGIIVYCYVRILQTL---------MRTRTMRKH----RTVKLIFVIVLVFFLSWAPYNIVIFLRSL 224
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
70-302 2.10e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 49.04  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  70 SVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15395     9 AVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICHLRyGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTS------------CTLDWWL 217
Cdd:cd15395    89 FSLVLIAIERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVL-TSLPFLIFQVLTDEPFKNVnvsldaykgkyvCLDQFPS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 AQASLSGQTFVMAILFFClilPTGIIVFSYVMIIFKVKSSTKEVSHFdaRINNSHNLEMKLTKVAML-ICAGFLIAWIPY 296
Cdd:cd15395   167 DTIRLSYTTCLLVLQYFG---PLCFIFICYLKIYIRLKRRNNMMDKM--RDNKYRSSETKRINIMLIsIVVAFAVCWLPL 241

                  ....*.
gi 2116730773 297 AVVSVV 302
Cdd:cd15395   242 NIFNAV 247
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
73-334 2.30e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 48.65  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSF-AHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15921    12 ILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDL-LLVCTLPLRLTYYVlNSHWPFGDIACRIILYVLYVNMYSSIYF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDWWLAQASLsgQTFVMA 230
Cdd:cd15921    91 LTALSVFRYLALVWpYLYLRVQTHSVAGIICGLIWILMGL-ASSPLLFAKSKQHDEGSTRCLELAHDAVDKL--LLINYV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIFKVKSSTKEVShfdaRINNSHNLEMKLTKVAMLIcagFLIAWIPYAVVSVV------SA 304
Cdd:cd15921   168 TLPVGFVVPFMTVIFCYIFIIKNLLKPSPALG----RTRPSRRKACALIIISLGI---FLVCFLPYHIVRTIhliterQI 240
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 305 FGEPDSV-PIPVSVVPTL-LAKSSAMYNPIIY 334
Cdd:cd15921   241 KESCGYIlRVRKAAVITLcLAASNSCFDPLLY 272
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
69-302 2.38e-06

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 48.58  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd15000     7 LPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKIChLRYGTWLKRHHAFLCLVFVWVyAAFWATMPLI--------GWGNYAPepfgTSCTLDwwlaqa 220
Cdd:cd15000    87 VLALCAVSYDRLTAIV-LPSEARLTKRGAKIVIVITWI-VGLLLALPLAiyrsyrerQWKNFLE----TYCAEN------ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 slsgqTFVMAILFFCLI-----LPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHnlEMKLTKVAMLICAGFLIAWIP 295
Cdd:cd15000   155 -----TQVLPIYWHVIItvlvwLPLGIMLICYSAIFWKLDKYERRVLRREHPSVVRY--KKKAAKTLFIVLITFVVCRIP 227

                  ....*..
gi 2116730773 296 YAVVSVV 302
Cdd:cd15000   228 FTALIFY 234
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
78-338 2.54e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 48.50  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR-WLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15053    17 GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGkWYLGPILCDIYIAMDVMCSTASIFNLCAIS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCtldwwlaqaSLSGQTFVMAILFFC 235
Cdd:cd15053    97 IDRYIAVTQpIKYARQKNSKRVLLTIAIVWVVSAAIA-CPLLFGLNNVPYRDPEEC---------RFYNPDFIIYSSISS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 LILPTGIIVFSYVMIIFKVKSstkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSA----FGEPD-S 310
Cdd:cd15053   167 FYIPCIVMLLLYYRIFRALRR------------------EKKATKTLAIVLGVFLFCWLPFFTLNILNAicpkLQNQScH 228
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 311 VPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15053   229 VGPALFSLTTWLGYVNSFLNPIIYTIFN 256
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
148-338 2.84e-06

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 48.34  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyapepfGTSCTLDWWLAQASLSGQTF 227
Cdd:cd15343    86 SLTNLLVIAVERHISIMRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGW--------NCICNISACSSLAPIYSRSY 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTgIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGE 307
Cdd:cd15343   158 LVFWSVSNLVVFL-IMVVVYLRIYVYVQRKTNVLSPHTSGSINRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLLDGLNC 236
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15343   237 TRCGVQHVKRWFLLLALLNSVMNPIIYSYKD 267
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
66-305 3.19e-06

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 48.26  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGImsaTGNGYVIYMTI-KRKTKLKP-PELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFF 143
Cdd:cd15122     8 LLAALLGL---PGNGFIIWSILwKMKARGRSvTCILILNLAVAD-GAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLKICHLRYGTWL-KRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTS----CTLDWWLA 218
Cdd:cd15122    84 SMYASIFIIGLMSLDRCLAVTRPYLAQSLrKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRicepCHASRGHA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 QASLSGQTFVmailffCLILPTGIIVFSYVMIIFKVKsstkevshfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15122   164 IFHYTFETLV------AFVLPFGVILFSYSVILVRLK-------------GARFRRRARVEKLIAAIVVAFALLWVPYHV 224

                  ....*..
gi 2116730773 299 VSVVSAF 305
Cdd:cd15122   225 VNLLQVV 231
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
64-303 3.39e-06

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 48.86  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  64 VRLLDLSVGIMSATGNGYVIYMTIKRKTKlKPPELMTVNLAIFDFgISVTGKPFFIVSSFaHRWLFGWEGCQFYG---WA 140
Cdd:PHA02638  101 IKIFYIIIFILGLFGNAAIIMILFCKKIK-TITDIYIFNLAISDL-IFVIDFPFIIYNEF-DQWIFGDFMCKVISasyYI 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 141 GFFfgcGSLITMTMVSLDRYLKIChlrYGTWLKRHHAF-----LC--------LVFVWVYAAFWATMPLIGWGNYAPEPF 207
Cdd:PHA02638  178 GFF---SNMFLITLMSIDRYFAIL---YPISFQKYRTFnigiiLCiiswilslIITSPAYFIFEASNIIFSAQDSNETIS 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 208 GTSCTL--DWWLAQASLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNshnlemkltkvAMLI 285
Cdd:PHA02638  252 NYQCTLieDNEKNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVS-----------IIII 320
                         250
                  ....*....|....*...
gi 2116730773 286 CAgfLIAWIPYAVVSVVS 303
Cdd:PHA02638  321 CS--LICWIPLNIVILFA 336
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
79-298 4.63e-06

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 47.85  E-value: 4.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVS-SFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15968    18 NSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALS-LPLLIYNyAMRDRWLFGDFMCRLVRFLFYFNLYGSILFLTCISV 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMPLIGWGNYAPEPFGTSC---TLDWWLAQASLSGqtfvMAILF 233
Cdd:cd15968    97 HRYLGICHpMRPWHKETRRAAWLTCVLVWI-LVFAQTLPILIFARTGIIRNRTVCydlAPPALFPHYVPYG----MALTV 171
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 234 FCLILPTGIIVFSYVMIIFKVKSSTKEVShfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAV 298
Cdd:cd15968   172 SGFLLPFSIILWCYCLVVRTLCRTLGPAE------PPAQARRRKSIRTIVTVTLLFALCFLPFHI 230
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
71-334 4.85e-06

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 47.61  E-value: 4.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygWAGFFFGC--GS 148
Cdd:cd15335    10 ITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEI--WLSVDMTCctCS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLdwwlaQASLSGQTF 227
Cdd:cd15335    88 ILHLCVIALDRYWAITDaIEYARKRTAKRAGLMILTVWTISIF-ISIPPLFWRNHHDANIPSQCII-----QHDHVIYTI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAilFFCLILPTGIIVFSYvmiifkvksstkevshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFgE 307
Cdd:cd15335   162 YST--FGAFYIPLTLILILY------------------YRIYHAASRERKAARILGLILGAFILSWLPFFIKELIVGL-S 220
                         250       260
                  ....*....|....*....|....*..
gi 2116730773 308 PDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15335   221 VMTVSPEVADFLTWLGYVNSLVNPLLY 247
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
129-303 5.37e-06

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 47.44  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 129 FGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPepf 207
Cdd:cd15905    63 RGYHSCLFVYVAPNFLFLSFLANLLMVHYERYLCIVYpLQYHNFWVHRWVPLALLLTWALPLLFACLPALGWNNWTP--- 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 208 GTSCTldwwlaqaslSGQTFVMAILF---FCLILPT-GIIVFSYVMIIFKVKSSTKEVSHF------DARINNSHNLEMK 277
Cdd:cd15905   140 GSNCS----------YKQVFPAAYIYlevYGLVLPSiLAIAFMSVRVLAVARRQLQDICKLlravqrDGPSELEQQLNLR 209
                         170       180
                  ....*....|....*....|....*.
gi 2116730773 278 LTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15905   210 YAKCIAGVSLTFLVCWVPYIAYLLMS 235
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
77-262 6.83e-06

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 47.09  E-value: 6.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15199    16 PGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLIC-LPFKAYFYLNGnRWSLGGGTCKALLFMLSLSRGVSIAFLTAV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGT-WLKRHHAFLCLVFVWVYAafwatMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFF 234
Cdd:cd15199    95 ALDRYFRVVHPRGKKnSLSLQAAPYISFLVWLLL-----VGLTIPTLLASQPKNFTECNSFSPKDDEDFSDTWQEAVFFL 169
                         170       180
                  ....*....|....*....|....*...
gi 2116730773 235 CLILPTGIIVFSYVMIIFKVKSSTKEVS 262
Cdd:cd15199   170 QFLLPFGLIVFCTVRIIRRLKKRLRDVG 197
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
73-299 7.91e-06

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 47.10  E-value: 7.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAhRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15187    12 VFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDL-LFVFSLPFQAYYLLD-QWVFGNAMCKIVSGAYYIGFYSSMFFI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHLRYGTWLK--RHHAFLCLVfVWVyAAFWATMPLIGWGNYAPEPFGTSCTLDWwlAQASLSGQTFV-M 229
Cdd:cd15187    90 TLMSIDRYLAIVHAVYALKVRtaSHGTILSLA-LWL-VAILASVPLLVFYQVASEDGRLQCIPFY--PGQGNSWKVFTnF 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AILFFCLILPTGIIVFSYVMIIFKVKSStkevshfdarinNSHNlEMKLTKVAMLICAGFLIAWIPYAVV 299
Cdd:cd15187   166 EVNILGLLIPFSILIFCYHNILRNLRRC------------HNQN-KTKAIKLVFIVVIVFFLFWTPFNVV 222
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
96-334 8.08e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 47.07  E-value: 8.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  96 PELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKR 174
Cdd:cd15219    35 PGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFpLSYTSKMRY 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 175 HHAFLCLVFVWVYA-AFWATMPLIGWGNYApePFGTSCTLDWWLAQASLSGQTFVMAILFFCLILPTGIIVFSYVMiIFK 253
Cdd:cd15219   115 RDAALMVGYSWLHSlTFSLVALFLSWLGYS--SLYASCTLHLPREEERRRFAVFTAFFHAFTFLLSLLVLCVTYLK-VLK 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 254 VK---SSTKEVSHFdarinnshnlemkltkvamliCAGFLIAWIPYAVVSVVSAFgepDSVPIPV--SVVPTLLAKSSAM 328
Cdd:cd15219   192 VRrrqRATKKISIF---------------------IGTFVLCFAPYVITRLVELL---PFVTINRywGIVSKCLTYSKAA 247

                  ....*.
gi 2116730773 329 YNPIIY 334
Cdd:cd15219   248 SDPFVY 253
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
71-338 8.85e-06

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 46.77  E-value: 8.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15194    10 VFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMYCSVF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA-------TMPLIGWGNYAPEPFGTSCTLDWwlaqasl 222
Cdd:cd15194    90 LLTCMSLDRYLAIVLpLVSRKFRTKHNAKVCCTCVWMLSCLLGlptllsrELKKYEEKEYCNEDAGTPSKVIF------- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 223 sgqtfVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemklTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15194   163 -----SLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRKS-------IKIVFIVVAAFVFSWMPFNLFKAL 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2116730773 303 S-AFGEPDSVPIPVSVVPTL-------LAKSSAMYNPIIYQVVD 338
Cdd:cd15194   231 AiASGLQVEVTCLPYTLAQLgmevsapLAFANSCANPFIYYFFD 274
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
77-338 9.39e-06

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 46.66  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMtIKRKTKLKP-PELMTVNLAIFDfGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15087    16 TGNTAVIYV-ILRAPKMKTvTNVFILNLAIAD-DLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKI---CHLRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGN-YAPEPFGTSCTLD-------WWlaQASlSG 224
Cdd:cd15087    94 SVDRYLVVlatVRSRRMPYRTYRAAKIVSLCVWLLVTI-IVLPFTVFAGvYSNELGRKSCVLSfpspeslWF--KAS-RI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAilffcLILPTGIIVFSYVMIIFKVKSStkevsHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSA 304
Cdd:cd15087   170 YTLVLG-----FAIPVSTICILYTMMLYKLRNM-----RLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVAL 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2116730773 305 FGEPDSVP--IPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15087   240 TTDLPQTPlvIGISYFITSLSYANSCLNPFLYAFLD 275
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
78-334 1.01e-05

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 46.66  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSsFAH--RWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15158    17 GNGFALYVLIKTYRQKSAFHIYMLNLAVSDL-LCVCTLPLRVVY-YVHkgQWLFGDFLCRISSYALYVNLYCSIYFMTAM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKIC----HLRYGTWLKrhhAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCtldwWLAQASLSGQTFVMAI 231
Cdd:cd15158    95 SFTRFLAIVfpvqNLNLVTVKK---ARIVCVGIWIFVTL-TSSPFLMSGSHDTETNKTKC----FEPPQSNQQLTKLLVL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 ----LFFCLILPTGIIVFSYVMIIFKVKSSTkevshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAV-----VSVV 302
Cdd:cd15158   167 nyisLVVGFIIPFLVILICYAMIIRTLLKNT-------MKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIqrtihLHFL 239
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 303 SAFGEP--DSVPIPVSVVPTL-LAKSSAMYNPIIY 334
Cdd:cd15158   240 SRKDSTceEVLYMQKSVVITLcLAAANCCFDPLLY 274
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
102-334 1.08e-05

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 46.78  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15957    41 SLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSpFKYQSLLTKNKARVI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 181 LVFVWVYAAFWATMPLIGWGNYAPEPFGTSCtldwwLAQAS----LSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKS 256
Cdd:cd15957   121 ILMVWIVSGLTSFLPIQMHWYRATHQEAINC-----YAEETccdfFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 257 STKEVSHFDARINNSHNL-------------------EMKLTKVAMLICAGFLIAWIPYAVVSVVSAFgEPDSVPIPVSV 317
Cdd:cd15957   196 QLQKIDKSEGRFHNQNIDqngsgggggnrrrskfclkEHKALKTLGIIMGTFTLCWLPFFIVNIVHVI-QDNLIRKEVYI 274
                         250
                  ....*....|....*..
gi 2116730773 318 VPTLLAKSSAMYNPIIY 334
Cdd:cd15957   275 LLNWIGYVNSGFNPLIY 291
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
81-307 1.14e-05

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 46.61  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  81 YVIYMTIKRKTKLKppeLMTVNLAIFDFgISVTGKPFFIVSSF-AHRWLFGWEGCQFygwAGFFFGCGSLIT---MTMVS 156
Cdd:cd15160    23 WVLYLQIKKENVLG---VYLLNLSLSDL-LYILTLPLWIDYTAnHHNWTFGPLSCKV---VGFFFYTNIYASigfLCCIA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWV------YAAFWATMPLIGWGNYapepfgTSC----TLDWWLAqaslsgq 225
Cdd:cd15160    96 VDRYLAVVHpLRFRGLRTRRFALKVSASIWVlelgthSVFLGHDELFRDEPNH------TLCyekyPMEGWQA------- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARInnshnlemklTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15160   163 SYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKI----------IGLLLSIVVIFLLCFLPYHVVLLVRSV 232

                  ..
gi 2116730773 306 GE 307
Cdd:cd15160   233 IE 234
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
77-334 1.34e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 46.20  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFA-HRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15067    15 AGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTgGYWLFGRDWCDVWHSFDVLASTASILNLCVI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTS-CTLDWWLAQASLSGqtfvmAILF 233
Cdd:cd15067    95 SLDRYWAITDpISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNqCLFTDDSGYLIFSS-----CVSF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 234 FClilPTGIIVFSYvmiifkvksstkevshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPI 313
Cdd:cd15067   170 YI---PLVVMLFTY------------------YRIYRAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSN 228
                         250       260
                  ....*....|....*....|...
gi 2116730773 314 PVSVVP--TLLAKSSAMYNPIIY 334
Cdd:cd15067   229 PDILFPlvTWLGYINSGMNPIIY 251
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
127-340 1.62e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.94  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 127 WLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWG----N 201
Cdd:cd15928    66 WRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHpLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGvehiQ 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 202 YAPEPFGTSCTlDWWLAQASLSGQTFVMAILFFcliLPTGIIVFSYVMIIFKVKSSTKEVSHFDA-RINNSHNLEMKLTK 280
Cdd:cd15928   146 GQQTPRGFECT-VVNVSSGLLSVMLWVSTSFFF---VPMVCLSLLYGLIGRALWDRRQRSRTAGAsRRDNNHRQTVRMLA 221
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 281 VAMLIcagFLIAWIPYAVVSVVSAFGEPDSVPIP-----VSVVPTLLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15928   222 VIVLA---FVLCWLPFHVGRVIFNHSRASTKHLHyvsqyFNLVSFVLFYLSAAINPILYNLMSKR 283
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
71-340 1.81e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 45.73  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSfAHRWLFGWEGCQFYGW---AGFFfgcG 147
Cdd:cd15178    10 VFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALT-LPFWAVSV-VKGWIFGTFMCKLVSLlqeANFY---S 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRHHA-FLCLVfVWVYAAFWATMPLIGWGNYAPEP---------FGTSCTLDWWL 217
Cdd:cd15178    85 GILLLACISVDRYLAIVHATRALTQKRHLVkFVCAG-VWLLSLLLSLPALLNRDAFKPPNsgrtvcyenLGNESADKWRV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 AQASLSgQTFVmailFFcliLPTGIIVFSY---VMIIFKVKSSTKEvshfdarinnshnlemKLTKVAMLICAGFLIAWI 294
Cdd:cd15178   164 VLRILR-HTLG----FL---LPLVVMLFCYgftIKTLLQTRSFQKH----------------RAMRVIFAVVLAFLLCWL 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 295 PYAVVSVVSAFGEPDSVP--------IPVSVVPT-LLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15178   220 PYNVTVLIDTLMRTKLITetcelrnhVDVALYVTqILGFLHSCINPVLYAFIGQK 274
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
69-340 1.86e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 45.94  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGIsVTGKPFFIVSSFAHR-WLFGWEGCQFYGWagFFFGC- 146
Cdd:cd15132     8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLYRLWKSRpWIFGEFLCRLYHY--ISEGCt 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 -GSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWG-----NYAPEPFGTSCTLDWWLAQ 219
Cdd:cd15132    85 yATILHITALSIERYLAICFpLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGveqdnNIHPDDFSRECKHTPYAVS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 ASLSGQTF-VMAILFFClilPTGIIVFSYVMIIFKV-KSSTKEVSHFDARINNSHNLEMKLTKVAMLicaGFLIAWIPYA 297
Cdd:cd15132   165 SGLLGIMIwVTTTYFFL---PMLCLSFLYGFIGRKLwKSKNDLRGPNAAARERSHRQTVRILAVVVL---AFIICWLPFH 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 298 VVSVVSAFGEPDSVPI---PVSVVPTLLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15132   239 IGRILFANTEDYRTMMfsqYFNIVAMQLFYLSASINPILYNLISRK 284
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
71-334 2.26e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 45.61  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFgwEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15071    10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF--YSCLMVACPVLILTQSSIL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKI-CHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNyapepfgTSCTLDWWLAQASLSG----- 224
Cdd:cd15071    88 ALLAIAVDRYLRVkIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNN-------LNAVERAWAANSSMGElvikc 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 -------QTFVMAILFFCLILPTGIIVFSYVMIIFKV--KSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIP 295
Cdd:cd15071   161 qfetvisMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLirKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWLP 240
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 296 YAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15071   241 LHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVY 279
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
73-334 2.44e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 45.76  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRK-TKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQ---FYGWAGFFFGCGS 148
Cdd:cd15382    12 LIAAVGNLTVLLILLRNRrRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRlmlFFRAFGLYLSSFV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMtmvSLDRYLKICHLRYGTWLKRHHAFLcLVFVWVYAaFWATMPLIGWGNYAPEPfgtscTLDWWlaQASLSGQTF- 227
Cdd:cd15382    92 LVCI---SLDRYFAILKPLRLSDARRRGRIM-LAVAWVIS-FLCSIPQSFIFHVESHP-----CVTWF--SQCVTFNFFp 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 ----VMAILFFCLI----LPTGIIVFSYVMIIFKVKSSTKEV--------SHFDARINNSHNLE---MKLTKVAMLICAG 288
Cdd:cd15382   160 shdhELAYNIFNMItmyaLPLIIIVFCYSLILCEISRKSKEKkedvseksSSVRLRRSSVGLLErarSRTLKMTIVIVLV 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2116730773 289 FLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTL--LAKSSAMYNPIIY 334
Cdd:cd15382   240 FIICWTPYFIMSLWYWFDRESASKVDPRIQKGLflFAVSNSCMNPIVY 287
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
78-336 2.99e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 45.04  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygWAGFFFGC--GSLITMTMV 155
Cdd:cd15331    17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDM--WISMDVLCctASILHLVAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWG--NYAPEPFGTS-CtldwwLAQASLSGQTFVMAIL 232
Cdd:cd15331    95 ALDRYWAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKdeDDLDRVLKTGvC-----LISQDYGYTIFSTVGA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFCLILptgiivfsyVMIIFKVKsstkevshfdarINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVP 312
Cdd:cd15331   170 FYVPLL---------LMIIIYWK------------IYQAAKRERKAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQIS 228
                         250       260
                  ....*....|....*....|....
gi 2116730773 313 IPVSVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15331   229 RFLESFFLWLGYFNSLLNPIIYTI 252
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
102-194 3.02e-05

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 45.14  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFG-ISVTgKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHhafL 179
Cdd:cd15227    41 NLSFLDLCyISVT-VPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHpLHYEVIMNRG---A 116
                          90
                  ....*....|....*...
gi 2116730773 180 CL---VFVWVYAAFWATM 194
Cdd:cd15227   117 CVqmaAASWLSGLLYGAL 134
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
73-310 3.10e-05

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 45.13  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSsFAHRWLFGWEGCQFY-GWAGFFFGCGSLIt 151
Cdd:cd15172    12 VVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLT-LPFWAVY-EAHQWIFGNFSCKLLrGIYAINFYSGMLL- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH------LRYGTWLKRHhaFLCLVfVWVYAAFWATMPLIGWGNYAPEPFGTS-CTLDWWLAQASLSG 224
Cdd:cd15172    89 LACISVDRYIAIVQatksfrLRSRTLAYSK--LICAA-VWLLAILISLPTFIFSEVYDFGLEEQYvCEPKYPKNSTAIMW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 225 QTFVMAI-LFFCLILPTGIIVFSYVMIIfkvksstkeVSHFDARINNSHnlemKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15172   166 KLLVLSLqVSLGFFIPLLVMIFCYSFII---------KTLLQAQNSQRH----KAVRVVVAVVLVFLVCQVPYNIVLLIE 232

                  ....*....
gi 2116730773 304 A--FGEPDS 310
Cdd:cd15172   233 AinLGEQQS 241
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
78-305 3.19e-05

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 45.20  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSL 157
Cdd:cd15295    17 GNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISY 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 158 DRYLKICH--LRYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAPEPfGTSCTLDWwlaqasLSGQTFVMAILFFC 235
Cdd:cd15295    97 DRYQSVSNavSYRNQQTATLRIVTQMVAVWVL-AFLVHGPAILVSDSWKTE-DGECEPEF------FSNWYILAITSVLE 168
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 LILPTGIIVFSYVMIIFKVKSSTKevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15295   169 FLVPVILVAYFNTQIYWSLWKRLR---------------DRKLAKSLAIILGTFAICWAPYSLFTIIRAA 223
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
66-334 4.28e-05

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 44.73  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFA-HRWLFGWEGCQFYGWAGFFF 144
Cdd:cd15302     5 LITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNgDYWPLGWVLCDLWLSVDYTV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 145 GCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYApepfGTSCTLDWWLAQASLS 223
Cdd:cd15302    85 CLVSIYTVLLITIDRYCSVKIpAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFT----GQGRSLPEGECYVQFM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 224 GQTFVMAILFFCLILPTGIIVFSYVMIIFKVKsstkevshfdarinnshNLEMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15302   161 TDPYFNMGMYIGYYWTTLIVMLILYAGIYRAA-----------------NRARKALRTITFILGAFVICWTPYHILATIY 223
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 304 AFGE-PDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15302   224 GFCEaPPCVNETLYTISYYLCYMNSPINPFCY 255
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
102-334 4.30e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 44.58  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15330    41 SLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDpIDYVNKRTPRRAAVL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 181 LVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDwwlaqaslSGQTFVMAILFFCLILPTGIIVFSYvmiifkvksstke 260
Cdd:cd15330   121 ISLTWLIGFSISIPPMLGWRTPEDRSDPDACTIS--------KDPGYTIYSTFGAFYIPLILMLVLY------------- 179
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 261 vshfdARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDS-VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15330   180 -----GRIFKAAARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTChMPELLGAIINWLGYSNSLLNPIIY 249
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
78-302 4.99e-05

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 44.79  E-value: 4.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFF---IVSSFahRWLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:cd15380    17 GNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLPFWaenIRNQF--NWPFGNFLCRVISGVIKANLFISIFLVVA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMP-LIGWGNYAPEPFGTSCTLDWwLAQASLSGQTFVMAIL 232
Cdd:cd15380    94 ISQDRYRTLVHtMTSRRQRSRRQAQVICLLIWVFGGLLSIPTfLFRSVKHVPDLNISACILLF-PHEAWHFARRVELNIV 172
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 233 FFclILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNShnlemKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15380   173 GF--LLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDT-----KATRLILTLVLMFLVCWTPYHFFAFL 235
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
71-337 5.34e-05

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 44.48  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAHRWLFGWEGCQFYgwAGFFF-GCGS- 148
Cdd:cd15183    10 VFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDAMCKFL--SGFYYlGLYSe 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICHLRYGTWLKR-HHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTL--------DWWLAQ 219
Cdd:cd15183    87 IFFIILLTIDRYLAIVHAVFALRARTvTFGIITSIITWALAIL-ASMPCLYFFKSQWEFTHHTCSAhfprksliRWKRFQ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 AslsgqtfvMAILFFCLILPTGIIVFSYVMIIfkvksstkEVSHfdARINNSHNLEMKLTKVAMLIcagFLIAWIPYAVV 299
Cdd:cd15183   166 A--------LKLNLLGLILPLLVMIICYTGII--------NILL--RRPNEKKAKAVRLIFVITLL---FFLLWTPYNLA 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 300 SVVSAFGE-------PDSVPIPVSV-VPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15183   225 AFVSAFQDvlftpscEQSQQLDLALqVTEVIAYTHCCVNPVIYVFV 270
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
78-264 5.71e-05

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 44.39  E-value: 5.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGyVIYMTIKRKTKLKPPELMTV-NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15946    17 GNG-LIITLICLDSRLHTPMYFFLsVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA------TMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVM 229
Cdd:cd15946    96 YDRYVAICHpLRYKVIMSWGLCILMVAGSWVCGVFSSllhtffTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVD 175
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2116730773 230 AIL-FFCLILPTGIIVFSYVMI---IFKVKSSTKEVSHF 264
Cdd:cd15946   176 FVLgVIVLVVPLSLILASYVNIfkaILKIRSTQGRCKAF 214
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
71-334 6.75e-05

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 44.40  E-value: 6.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15056    10 VILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMP-LIGWGN--------YAPEPFGTSCTLdwwlaqas 221
Cdd:cd15056    90 HLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPiMQGWNHigiedliaFNCASGSTSCVF-------- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSH----------NLEMKLTKVAMLICAGFLI 291
Cdd:cd15056   162 MVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAGSSNHeadqhrnsrmRTETKAAKTLGIIMGCFCV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2116730773 292 AWIPYAVVSVVSAFGEpDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15056   242 CWAPFFVTNIVDPFIG-YRVPYLLWTAFLWLGYINSGLNPFLY 283
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
140-334 7.37e-05

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 44.00  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLITMTmvsLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPepfGTSCTLDWWLA 218
Cdd:cd15100    78 AAFSASVCSLLAIT---VDRYLSLYNaLTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLRE---GSSCSVVRPLT 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 Q---ASLSGQTFVMAILFFCLILPTGIIVFSYVMIIfKVKSSTKEVSHFDARINNSHNLEmkltkvamLICAGFLIAWIP 295
Cdd:cd15100   152 KnhlAVLAVAFLLVFALMLQLYAQICRIVLRHAHQI-ALQRHFLAPSHYVATRKGVSTLA--------LILGTFAACWIP 222
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2116730773 296 YAVVSVVSAFGEPdsvpiPVSVVPTLL-AKSSAMYNPIIY 334
Cdd:cd15100   223 FAVYCLLGDGSSP-----ALYTYATLLpATYNSMINPIIY 257
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
69-337 7.50e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 44.17  E-value: 7.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELM---TVNLAIFDFGISVTGKPFFIVSS--FAHRWLFGWEGCQFYGWAGFF 143
Cdd:cd15130     8 LALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPVELYNFiwVHHPWAFGDAGCRGYYFLRDA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA-----TMPLIGWGNYAPEPFGTSCTLdwWL 217
Cdd:cd15130    88 CTYATALNVASLSVERYLAICHpFKAKTLMSRSRTKKFISAIWLASALLAipmlfTMGLQNESDDGTHPGGLVCTP--IV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 AQASLsgQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKevshfdarinnshnlemKLTKVAMLICAGFLIAWIPYA 297
Cdd:cd15130   166 DTATL--KVVIQVNTFMSFLFPMLVTSILNTVIANKLVQALR-----------------RGVLVLRAVVIAFVVCWLPYH 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2116730773 298 VVSVVSAFGEPDSVPIPV-------SVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15130   227 VRRLMFCYISDEQWTTFLfdfyhyfYMLTNALFYVSSAINPILYNLV 273
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
103-320 8.68e-05

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 44.04  E-value: 8.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 103 LAIFDF-GISVTGKpffIVSSFaHRWLFGWEG-------CQFYGWAGFFFGCGSLITMTMVSLDRYLKI-CHLRYGTWLK 173
Cdd:cd15143    47 LVVTDFlGLLVTGT---IVISF-HLTNFNWRVvdpdcylCNFMGLSMVFYGLCPLLLGATMAVERFFGInRPFSRSTAMS 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 174 RHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDwwLAQASlSGQTFVMaILFFCLILPTGI-IVFSYVMIIF 252
Cdd:cd15143   123 KRRAWYMVGMVWAFAFLLGLLPILGLGRYTLQYPGSWCFLT--LLFDS-KDVAFGL-LFSFLGILSVGLsFLLNTVSVVT 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2116730773 253 KVKSSTKEVSHFDARinnSHNLEMKLTKVAMLICAGflIAWIPYAVVSVVSAFGEPDSVPIPVSVVPT 320
Cdd:cd15143   199 LCRVYHDRESVQRRR---DSEVEMMVQLLGIMVIAS--VCWLPLLVFIAQTVLQKPPAMLLAGQIPRL 261
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
77-334 1.02e-04

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 43.57  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKlKPPELMTVNLAIFDFGISVTgKPFFIVS-SFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15117    16 LGNGLVIWVTGFRMTR-TVTTVCFLNLAVADFAFCLF-LPFSVVYtALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYlkICHLrYGTWLKRHH----AFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDW---------WLAQASL 222
Cdd:cd15117    94 SLDRC--VSVL-WPVWARNHRtparAALVAVGAWLLALA-LSGPHLVFRDTRKENGCTHCYLNFdpwnetaedPVLWLET 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 223 SGQTFVMAIL---FFCLILPTGIIVFSYVMIIFK------VKSStkevshfdarinnshnlemKLTKVAMLICAGFLIAW 293
Cdd:cd15117   170 VVQRLSAQVItrfVLGFLVPLVIIGGCYGLIAARlwregwVHSS-------------------RPFRVLTAVVAAFFLCW 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2116730773 294 IPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAM------YNPIIY 334
Cdd:cd15117   231 FPFHLVSLLELVVILNQKEDLNPLLILLLPLSSSLacvnscLNPLLY 277
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
101-199 1.06e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 43.52  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 101 VNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFL 179
Cdd:cd15066    39 VSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQpLEYPSKMTKRRVAI 118
                          90       100
                  ....*....|....*....|.
gi 2116730773 180 CLVFVWVYAAFWATMPL-IGW 199
Cdd:cd15066   119 MLANVWISPALISFLPIfLGW 139
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
71-334 1.09e-04

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 43.57  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHR-WLFGWEGCQFYGWAGFFFGCGSL 149
Cdd:cd15394    10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVTVYVSV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 150 ITMTMVSLDRYLKICH-LRygtwlKRHHAFLC---LVFVWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQaSLSGQ 225
Cdd:cd15394    90 FTLTAIAVDRYYVTVYpLR-----RRISRRTCayiVAAIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFWFGQ-EKQRL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 TFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15394   164 AYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDI 243
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2116730773 306 GEPDSVPIPVSVVPTL---LAKSSAMYNPIIY 334
Cdd:cd15394   244 DIDLIDKQYFNLIQLLchwLAMSSACYNPFLY 275
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
102-194 1.31e-04

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 43.19  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15228    41 NLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHpLRYLLIMNRRVCALL 120
                          90
                  ....*....|....
gi 2116730773 181 LVFVWVYAAFWATM 194
Cdd:cd15228   121 AAGTWITSSFHATI 134
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
66-290 1.55e-04

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 43.20  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSatgNGYVIYMTIKRKTKLkPPELMTVNLAIFDFGISVTgKPFFIVSSF-AHRWLFGWEGCQFYgwAGFFF 144
Cdd:cd15372     8 TLVFLVGLPA---NGLALWVLATQVKRL-PSTIFLINLAVADLLLILV-LPFKISYHFlGNNWPFGEGLCRVV--TAFFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 145 G--CGSLITMTMVSLDRYLKICHLRYGTWL--KRHHAFLCLVfVWVYAAFwATMPLIGW-GNYAPEPFGTSCTLDWWLAQ 219
Cdd:cd15372    81 GnmYCSVLLLMCISLDRYLAVVHPFFARTLrsRRFALCMCTA-IWLIAAA-LTLPLTLQrQSYPLERLNITLCHDVLPLD 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2116730773 220 ASLSGQTFVMAILF-FCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlEMKLTKVAMLICAGFL 290
Cdd:cd15372   159 EQDTYLFYYFACLAvLGFLLPLVVILFCYGSVLHTLLRSGQRYGH-----------AMKLTVLVLVSFVLCF 219
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
71-334 1.56e-04

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 43.28  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15396    10 VTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICHLRyGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAPEPFGT------------SCTLDWWLA 218
Cdd:cd15396    90 SLVLIAIERYQLIVNPR-GWKPSASHAYWGIVLIWLF-SLMISIPFLIFHQLTDEPFRNlsshsdfykdkvVCIEAWPSE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 QASLsgqTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHF---DARINNSHNLEMKLTKvamlICAGFLIAWIP 295
Cdd:cd15396   168 TERL---IFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDRMrenESRLSENKRINTMLIS----IVVTFAACWLP 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 296 YAVVSVVSAFGEPDSVPIPVSVVPT---LLAKSSAMYNPIIY 334
Cdd:cd15396   241 LNIFNVVFDWNHEVLMSCHHNLVFTlchLVAMVSTCINPIFY 282
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
73-334 1.63e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 43.22  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFA-HRWLFGWEGCQFygwAGFFFGC---GS 148
Cdd:cd15358    12 VVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSnYPFLLGAGGCYF---KTLLFETvcfAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA----------TMPLIGWGnyaPEPFGTSCTLDWWL 217
Cdd:cd15358    89 ILNVTALSVERYIAVVHpLKAKYVVTRTHAKRVIGAVWVVSILCSipntslhgifQLTVPCRG---PVPDSATCMLVKPR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 218 AQASLSGQtfVMAILFFCliLPTGIIVFSYVMI-----------IFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLIC 286
Cdd:cd15358   166 WMYNLIIQ--ITTLLFFF--LPMGTISVLYLLIglqlkrekmllVLEAKGSKAGDSYQHRRIQQEKRRRRQVTKMLFVLV 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 287 AGFLIAWIPYAVVSVVSAF-----GEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15358   242 VVFGICWAPFHTDRLMWSFisqwtGELHLAFQYVHIISGVFFYLSSAANPVLY 294
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
148-338 1.73e-04

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 42.86  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyapepfGTSCTLDWWLAQASLSGQTF 227
Cdd:cd15342    86 SVANLLAIAVERHQTIFTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGW--------NCLCDLKRCSTMAPLYSRSY 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 vmaILFFCLI--LPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15342   158 ---LVFWALSnlLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQVVLLLDGL 234
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2116730773 306 GEPDSVPIPVSVVPTLLAKSSAMYNPIIYQVVD 338
Cdd:cd15342   235 GCESCNVLAYEKYFLLLAEINSLVNPIVYSYRD 267
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
73-251 1.90e-04

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 42.82  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAHR-WLFGWEGCqfygWAGFFF----GCG 147
Cdd:cd14991    12 VLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADF-LLLICLPFRIDYYLRGEhWIFGEAWC----RVNLFMlsvnRSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHlrygtwlkRHHAfLCLVFV----WVYAAFWA-----TMPLIGWGNYAPEPFGTSCT--LDWW 216
Cdd:cd14991    87 SIAFLTAVALDRYFKVVH--------PHHR-VNRMSVkaaaGVAGLLWAlvlllTLPLLLSTLLTVNSNKSSCHsfSSYT 157
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2116730773 217 LAQASLSGQTFVMAILFFcliLPTGIIVFSYVMII 251
Cdd:cd14991   158 KPSLSIRWHNALFLLEFF---LPLGLIVFCSVRIA 189
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
78-334 1.96e-04

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 42.78  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRkTKLKPPELMTVNLAIFDFgISVTGKPFFIVS-SFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15114    17 GNALVAWVTGFE-AKRSVNAVWFLNLAVADL-LCCLSLPILAVPiAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAIS 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKI-----CHLRYGTWLKRhhaFLCLVfVWVYAAFwATMPLIGWGNYAPEPF--GTSCTLDWwlaQASLSGQTFVM 229
Cdd:cd15114    95 ADRCLLVlrpvwCQNHRRARLAW---IACGA-AWLLALL-LTVPSFIYRRIHQEHFpeKTVCVVDY---GGSTGVEWAVA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 AI-LFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP 308
Cdd:cd15114   167 IIrFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSR-------------RTLKVVTAVVVGFFLCWTPYHVVGLIIAASAP 233
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2116730773 309 DSV---------PIPVSvvptlLAKSSAMYNPIIY 334
Cdd:cd15114   234 NSRllanalkadPLTVS-----LAYINSCLNPIIY 263
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
102-358 2.18e-04

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 42.65  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPF----FIVSSFAhrWLFGwegcqfygwagfFFGCGSLITMTMVSL------------DRYLKICH 165
Cdd:cd15204    41 NLALSDFLVAVFCLPFemdyYVVRQRS--WTHG------------DVLCAVVNYLRTVSLyvstnallviaiDRYLVIVH 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 166 LRYGTwLKRHHAFLCLVFVWVYAAFWA--------TMPLIGWGNyapepfgTSCTLDW--WLAQASLSGQTFVMAILFfc 235
Cdd:cd15204   107 PLKPR-MKRRTACVVIALVWVVSLLLAipsavyskTTPYANQGK-------IFCGQIWpvDQQAYYKAYYLFLFVLEF-- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 lILPTGIIVFSYVMIIFKV--KSSTKEVSHFDARInnshnLEMKLTKVAMLIC--AGFLIAWIPYAVVSVVSAFgepdsv 311
Cdd:cd15204   177 -VLPVLIMTLCYLRIVRKVwfRRVPGQQTEQIRRR-----LRRRRRKVRLLVVilTAFVLCWAPYYGYAIVRDF------ 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2116730773 312 pipvsvVPTLLAKSSaMYNPIIYQV--VDLKNSCAKSSCFKVLKK--RRHF 358
Cdd:cd15204   245 ------FPTLLSKEK-LNTTIFYIVeaLAMSNSMINTVVYVAFNNniRKYL 288
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
148-334 2.44e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 42.23  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgNYAPEPfgTSCTLDWWLAQASLsgqT 226
Cdd:cd15962    83 SVSSLLAITVDRYLSLYNaLTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGW-NCLEER--ASCSIVRPLTKSNV---T 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLILptgiIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAG-FLIAWIPYAVVSVVSAF 305
Cdd:cd15962   157 LLSASFFFIFIL----MLHLYIKICKIVCRHAHQIALQQHFLTASHYVATKKGVSTLAIILGtFGASWLPFAIYCVVGDH 232
                         170       180       190
                  ....*....|....*....|....*....|
gi 2116730773 306 GEPdsvpiPVSVVPTLL-AKSSAMYNPIIY 334
Cdd:cd15962   233 EYP-----AVYTYATLLpATYNSMINPIIY 257
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
73-194 2.67e-04

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 42.29  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGC--QFYGWagFFFGCGSLI 150
Cdd:cd15915    12 LASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCisQLHFF--HFLGSSEAM 89
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATM 194
Cdd:cd15915    90 LLAVMAYDRYVAICNpLRYTVIMNPQVCLLLAVACWVTGFFHALM 134
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
89-235 2.87e-04

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 42.50  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  89 RKTKLKPPELMTVNLAIFDF-GISVTGKPFFIvsSFAHRW-LFGWEG----CQFYGWAGFFFGCGSLITMTMVSLDRYLK 162
Cdd:cd15141    32 RRTKSSAFCVLVTGLAATDLlGTCFLSPMVFV--SYAQNSsLLGLAAgqplCHLFAFAMTFFGLASMLILFAMAVERCLA 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 163 ICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSC-------------TLDWWLAQASLSGqtFV 228
Cdd:cd15141   110 ISHpYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWCfirmtvpghrepgSLAFSLLYASLMA--LL 187

                  ....*..
gi 2116730773 229 MAILFFC 235
Cdd:cd15141   188 IAAIFLC 194
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
66-186 3.09e-04

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 42.10  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMSATG---NGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSFAH-RWLFGWEGCQFYGWAG 141
Cdd:cd15374     2 LLPVSYGLVFVVGlplNATALWLFIKRMRPWNPTTVYMFHLALSDT-LYVLSLPTLIYYYADHnHWPFGVVACKIVRFLF 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2116730773 142 FFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWV 186
Cdd:cd15374    81 YANLYCSILFLTCISVHRYVGICHpIRALRWVKPRHAYLICASVWL 126
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
63-305 3.28e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 42.02  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  63 GVRLLDLSVGIMsatGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGwagf 142
Cdd:cd14977     5 SLSLVIFAVGII---GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVP---- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 143 FFGCGSL----ITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWG----NYAPEPFGTSCTL 213
Cdd:cd14977    78 FIQVTSLgvtvFSLCALSIDRYRAAVNsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTvareSSLDNSSLTVCIM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 214 D--WWLAQASLSGQTFVMAILFFCliLPTGIIVFSYVMIIFKVKSSTKEVshfdariNNSHNLEMK----LTKVAMLICA 287
Cdd:cd14977   158 KpsTPFAETYPKARSWWLFGCYFC--LPLAFTAVCYLLMARTLIRAAKEY-------TRGTKKHMKqrrqLAKTVLCLVL 228
                         250
                  ....*....|....*...
gi 2116730773 288 GFLIAWIPYAVVSVVSAF 305
Cdd:cd14977   229 VFAFCWLPEHISNILRAT 246
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
69-186 3.56e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 41.86  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGyVIYMTIKRKTKLKPPE-LMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGC--QFYgwagFF-- 143
Cdd:cd15232     8 LFLYAAALTGNS-LIILAISTSPKLHTPMyFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCmaQLY----FFtw 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2116730773 144 FGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWV 186
Cdd:cd15232    83 SLGSELLLLTAMAYDRYVAICHpLHYSTIMRKEVCVGLATGVWA 126
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
134-303 3.66e-04

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 42.07  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 134 CQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCT 212
Cdd:cd15144    81 CQFFGACMVFFGLCPLFLGCAMAVERCVGVTRpLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWCF 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 213 LDwwlAQASLSGQTFVMAILFFCLILPTgiIVFSYVMIIFK----VKSSTKEVSHFDARINNSHNLEM--KLTKVAMLIC 286
Cdd:cd15144   161 IK---VQPPGSWADVAFALLFSLLGLAS--LLVSLVCNTISgltlVRARLRKKCSCSNRRAKSHDIEMvvQLVGIMVVSC 235
                         170
                  ....*....|....*..
gi 2116730773 287 agflIAWIPYAVVSVVS 303
Cdd:cd15144   236 ----ICWSPLLIFVLIS 248
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
73-305 4.03e-04

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 41.75  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15404    12 LVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAIL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHLRygTWLKRHHAFLCLVFVWVyAAFWATMPL-IGWGNYAPEPFGTSCTLDWwlaQASLSGQTFVMAI 231
Cdd:cd15404    92 LIISIDRFLIIVQKQ--DKLNPYRAKVLIAVSWA-VSFCVAFPLaVGSPDLQIPSRAPQCVFGY---TTNPGYQAYVILI 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKVKSstkevshFDARinnshnlemKLTKVAMLICAgFLIAWIPYAVVSVVSAF 305
Cdd:cd15404   166 MLIFFFIPFMVMLYSFMGILNTVRS-------FKTR---------AFTTILILFIV-FTVCWAPFTTYSLVATF 222
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
127-340 4.19e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 41.79  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 127 WLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVyAAFWATMP---LIGWGN- 201
Cdd:cd15131    66 WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFpLRAKVVVTKRRVKLVILVLWA-VSFLSAGPifvLVGVEHe 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 202 YAPEPFGTS-C-TLDWWLAQASLSGQTFVMAILFFcliLPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMklT 279
Cdd:cd15131   145 NGTNPIDTNeCkATEYAVRSGLLTIMVWVSSVFFF---LPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQT--V 219
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 280 KVAMLICAGFLIAWIPYAVVS-VVSAFGEPDSVPIPV-----SVVPTLLAKSSAMYNPIIYQVVDLK 340
Cdd:cd15131   220 KMLAVVVFAFVLCWLPFHVGRyLFSKSFEAGSLEIALisqycNLVSFVLFYLSAAINPILYNIMSKK 286
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
134-197 4.24e-04

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 41.70  E-value: 4.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 134 CQFYgwagFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLI 197
Cdd:cd15912    77 SFFY----FFLGTTEFFLLAVMSFDRYVAICNpLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTI 137
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-334 4.59e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 41.64  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  77 TGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15197    16 VGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKICH-LRYGTWLKRHHAFLCLVfvWVYAAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMAILFFc 235
Cdd:cd15197    96 IDRYDAICHpMNFSQSGRQARVLICVA--WILSALFSIPMLIIFEKTGLSNGEVQCWILWPEPWYWKVYMTIVAFLVFF- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 liLPTGIIVFSYVMIIFKV----KSSTKEVSHFDARINNSHNL--------EMKLTKVAMLICAGFLIAWIPYAVVSVVS 303
Cdd:cd15197   173 --IPATIISICYIIIVRTIwkksKIQVTINKAGLHDGSSRRSSsrgiipraKIKTIKMTFVIVTVFIICWSPYFVFDLLD 250
                         250       260       270
                  ....*....|....*....|....*....|...
gi 2116730773 304 AFGE-PDS-VPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15197   251 VFGLlPRSkTKIAAATFIQSLAPLNSAINPLIY 283
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
147-342 5.53e-04

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 41.16  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 GSLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyapepfGTSCTLDWWLAQASLSGQT 226
Cdd:cd15344    85 ASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGW--------NCICDIENCSNMAPLYSDS 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLILPTGIIVFsYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFG 306
Cdd:cd15344   157 YLVFWAIFNLVTFVVMVVL-YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC 235
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2116730773 307 ePDSVPIPVSVVPTLLAKSSAMYNPIIYQVVDLKNS 342
Cdd:cd15344   236 -PQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMS 270
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
81-337 6.30e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 41.35  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  81 YVIYMTIKRKTKLKppeLMTVNLAIFDFgISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRY 160
Cdd:cd15166    23 WVFSCTTKKRTTVT---VYMMNVALVDL-IFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRY 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 161 LKICHLRYGTWLKR-HHAFLCLVFVWVyAAFWATMPLIgWGNYAPEP---FGTSCTLDWWLAQASLSGQTFVMAILFFcl 236
Cdd:cd15166    99 MAIVQPKHAKELKNtPKAVLACVGVWI-MTLASTFPLL-FLYEDPDKasnFTTCLKMLDIIHLKEVNVLNFTRLIFFF-- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 237 ILPTGIIVFSYVMIIF--------KVKSSTKEvshfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP 308
Cdd:cd15166   175 LIPLFIMIGCYLVIIHnlvhgrtsKLKPKVKE----------------KSIRIIITLIVQVLVCFVPFHICFAFLMLQNG 238
                         250       260
                  ....*....|....*....|....*....
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15166   239 DNSYNPWAAFTTFLMNLSTCLDVILYYIV 267
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
73-340 6.74e-04

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 40.91  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVSSfAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15179    12 LLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADL-LFVLTLPFWAVDA-AANWYFGNFLCKAVHVIYTVNLYSSVLIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICHLRYGTWLKRHHA--FLClVFVWVYAAFwATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd15179    90 AFISLDRYLAIVHATNSQRPRKLLAekVVY-VGVWLPALL-LTVPDLVFAKVSELDDRYICDRIYPEDTFELWVVAFRFQ 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 231 ILFFCLILPTGIIVFSYVMIIfkvksstkevshfdARINNSHNLE-MKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPD 309
Cdd:cd15179   168 HILVGLVLPGLVILTCYCIII--------------SKLSHSKGHQkRKALKTTVILILAFFACWLPYYIGISIDTFMLLE 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 310 SVPIPVSVVPTL---------LAKSSAMYNPIIYQVVDLK 340
Cdd:cd15179   234 IIKQSCEMEQTVhkwisiteaLAFFHCCLNPILYAFLGAK 273
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
102-186 6.92e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 41.03  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15226    41 NLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKpLHYLTIMSPRMCILL 120

                  ....*.
gi 2116730773 181 LVFVWV 186
Cdd:cd15226   121 VVASWI 126
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
102-185 7.92e-04

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 40.90  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15935    42 NLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHpLRYLAVMNRQLCIKL 121

                  ....*
gi 2116730773 181 LVFVW 185
Cdd:cd15935   122 LAACW 126
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
148-334 8.71e-04

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 40.57  E-value: 8.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 148 SLITMTMVSLDRYLKICHLRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgnyapepfgtSCTLDwwLAQASLSGQTF 227
Cdd:cd15345    86 STFSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGW----------NCLDN--LPDCSTILPLY 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 228 VMAILFFCLILPTGI---IVFSYVMIIFKVKSSTKEVShfdarinNSHNLE--MKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15345   154 SKKYVAFCISIFIAIlvaIVILYARIYILVKSSSRRVT-------NHRNSErsMALLRTVVIVVGVFIACWSPLFILLLI 226
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2116730773 303 SAFGEPDSVPI--PVSVVPTLLAKSSAMyNPIIY 334
Cdd:cd15345   227 DVACEVKQCPIlyKADWFIALAVLNSAM-NPIIY 259
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
71-337 8.92e-04

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 40.58  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  71 VGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFAHRWLFGWEGCQFYgwAGFFFGC--GS 148
Cdd:cd15185    10 VFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFT-LPFWIHYVRWNNWVFGHGMCKLL--SGFYYLGlySE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICHLRYGTWLKR-HHAFLCLVFVWVYAAFWATMPLIGWGnyAPEPFG-TSCTLDWWLAQASLSGQT 226
Cdd:cd15185    87 IFFIILLTIDRYLAIVHAVFALRARTvTFGIITSIITWGLAVLAALPEFIFYE--TQELFEeFLCSPLYPEDTEDSWKRF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 227 FVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFG 306
Cdd:cd15185   165 HALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKY-------------KAIRLIFVIMVVFFIFWTPYNLVLLLSAFQ 231
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2116730773 307 --------EPDSVPIPVSVVPTLLAKSSAMYNPIIYQVV 337
Cdd:cd15185   232 siffetdcERSKHLDLAMQVTEVIAYTHCCINPVIYAFV 270
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
69-298 1.01e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGImsaTGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd15927    11 FLVGV---LGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICH--LRYGTWLKRHHAfLCLVFVWVYAAFWA--------TMPLIGWGNY-----APEPFgtscTL 213
Cdd:cd15927    88 VFTLTALSADRYFAIVNpmRKHRSQATRRTL-VTAASIWIVSILLAipeaifshVVTFTLTDNQtiqicYPYPQ----EL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 214 DWWLAQAslsgQTFVMAILFFCliLPTGIIVFSYVMIIFKVKSSTKevsHFDARINNSHNLEM----KLTKVAMLICAGF 289
Cdd:cd15927   163 GPNYPKI----MVLLRFLVYYL--IPLLIIGVFYVLMARHLIRSTR---NIGSGQNQAAQRQIearkKVAKTVLAFVVLF 233

                  ....*....
gi 2116730773 290 LIAWIPYAV 298
Cdd:cd15927   234 AVCWLPRHV 242
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
181-334 1.05e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 40.54  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 181 LVFVWVYAAFWATMPLIGWGnyapepfgTSCTLDWWLAQASLSGQTFvmaiLFFCLILPTGI---IVFSYVMIIFKVKSS 257
Cdd:cd15349   120 IVLCWILAFLIGFLPLLGWN--------CLCDFRSCSSLLPLYSKSY----ILFCLVIFFIIlltIIGLYFAIYCLVRAS 187
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2116730773 258 TKEVSHfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSV--VPTLLAKSSAMyNPIIY 334
Cdd:cd15349   188 GQRVIS-----ARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGMewVLALAVLNSAI-NPLIY 260
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
147-334 1.16e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 40.40  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 147 GSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEpfgTSCTLDWWLAQASlsgq 225
Cdd:cd15961    82 ASVCSLLAITVDRYLSLYYaLTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADE---STCSVVRPLTKNN---- 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 226 tfvMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAMLICAG-FLIAWIPYAVVSVVSA 304
Cdd:cd15961   155 ---AAILSVSFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGtFAACWMPFTLYSLIAD 231
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2116730773 305 FGEPdsvpiPVSVVPTLL-AKSSAMYNPIIY 334
Cdd:cd15961   232 YTYP-----SIYTYATLLpATYNSIINPVIY 257
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
73-305 1.19e-03

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 40.51  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSFAH-RWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd14987    12 VIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVAT-LPVWVVSLVQHnQWPMGEFTCKITHLIFSINLFGSIFF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICHL-RYGTWLKRHHAFLCLVFVWVYaAFWATMPLIGWGNYAPEPFGTSCTLDWWLAQASLSGQTFVMA 230
Cdd:cd14987    91 LTCMSVDRYLSVTLFgNTSSRRKKIVRRIICVLVWLL-AFVASLPDTYFLKTVTSPSNNETYCRSFYPEESFKEWLIGME 169
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 231 ILFFCL--ILPTGIIVFSYVMIIFKVKSSTkevshfDARINNSHNLEMKLTKVamlicagFLIAWIPYAVVSVVSAF 305
Cdd:cd14987   170 LVSIVLgfVIPFPIIAVFYFLLARAISASS------DQERKSSRKIIFSYVVV-------FLVCWLPYHTVVLLDIL 233
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
69-181 1.40e-03

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 40.11  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd15942     8 LVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAE 87
                          90       100       110
                  ....*....|....*....|....*....|....
gi 2116730773 149 LITMTMVSLDRYLKICH-LRYGTwLKRHHAFLCL 181
Cdd:cd15942    88 CFLYTVMAYDRFLAICKpLHYST-IMNHRACLCL 120
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
66-334 1.43e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 39.95  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMS---ATGNGYVIyMTIKRKTKLKppelmTVN------LAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQF 136
Cdd:cd17790     2 LIVITTGILSlvtVTGNLLVL-ISFKVNSELK-----TVNnyfllsLACADLIIGAFSMNLYTTYILMGHWALGTVACDL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 137 YGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYA-AFWAtmPLIGWGNYapepfgtsctld 214
Cdd:cd17790    76 WLALDYVASNASVMNLLIISFDRYFSITRpLTYRAKRTPRRAAIMIGLAWLISfVLWA--PAILFWQY------------ 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 215 wwlaqasLSGQTFVMAILFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFdaRINNSHNLEMKLTKVAMLICAGFLIAWI 294
Cdd:cd17790   142 -------LVGERTVLAGQCYIQFLSQPIITFGTAIAAFYLPVTIMIILYW--RIYRETIKEKKAARTLSAILLAFILTWT 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 295 PYAVVSVVSAFGePDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd17790   213 PYNIMVLVSTFC-KDCVPKTLWELGYWLCYVNSTVNPMCY 251
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
73-334 1.47e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 40.11  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTiKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVS-SFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15119    12 VLGVPGNAIVIWVT-GFKWKKTVNTLWFLNLAIADF-VFVLFLPLHITYvALDFHWPFGVWLCKINSFVAVLNMFASVLF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICHLRygtWLKRHHA-----FLCLvFVWVYAAFWATMPLIGWGNYAPEPFGTSC-----TLDWWLAQAS 221
Cdd:cd15119    90 LTVISLDRYISLAHPV---WSHRYRTlksalILCG-IVWLSAAAISGPALYFRDTMELSINVTICfnnfhKHDGDLIVMR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LSGQTFVMaiLFFCLILPTGIIVFSYVMIIFKVKSSTKEVSHfdarinnshnlemKLTKVAMLICAGFLIAWIPYAVVSV 301
Cdd:cd15119   166 HTILVWVR--FFFGFLFPLLTMVVCYSLLAIKVKRRTLLISS-------------KFFWTISAVIVAFFVCWTPYHIFSI 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2116730773 302 V-------SAFGEPDSVPIPVSvvpTLLAKSSAMYNPIIY 334
Cdd:cd15119   231 LelsihhsSYLHNVLRAGIPLA---TSLAFINSCLNPILY 267
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
78-302 1.69e-03

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 39.67  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIvSSFAHR--WLFGWEGCQFYGWAGFFFGCGSLITMTMV 155
Cdd:cd15375    17 GNIIAIFVYLFKMRPWKSSTIIMLNLALTDL-LYVTSLPFLI-YYYINGesWIFGEFMCKFIRFIFHFNLYGSILFLTCF 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 156 SLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNyAPEPFGTSCTLD----------WWLaqaslsg 224
Cdd:cd15375    95 SIFRYVVIVHpLRAFQVQKRRWAIVACAVVWVISLA-EVSPMTFLIT-TKEKNNRTICLDftssdnlntiWWY------- 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2116730773 225 qTFVMAILFFCLilPTGIIVFSYVMIIFKVKSSTkevshfdariNNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVV 302
Cdd:cd15375   166 -NWILTVLGFLL--PLVIVTLCYTRIIYTLAKGP----------HTGSASKQKARRLIILILLVFYVCFLPFHILRVV 230
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
133-197 1.76e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 39.61  E-value: 1.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 133 GC--QFYgwagFFF--GCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLI 197
Cdd:cd15913    72 GCflQFY----FFFslGTTECFFLSVMAFDRYLAICRpLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVV 137
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
102-305 1.80e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 39.81  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLC 180
Cdd:cd15301    41 SLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRpLTYRARRTTKKAAVM 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 181 LVFVWVYAAFWATMPLIGW----GNYAPEPfgTSCTLDWWLAQASLsgqTFVMAILFFclILPTGIIVFSYVMIIFKVKS 256
Cdd:cd15301   121 IASAWIISLLLWPPWIYSWpyieGKRTVPA--GTCYIQFLETNPYV---TFGTALAAF--YVPVTIMCILYWRIWRETKK 193
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2116730773 257 STKEVshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd15301   194 RQKKQ-------------ESKAAKTLSAILLAFIVTWTPYNVLVLIKAF 229
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
140-334 1.96e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 39.89  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLItmtMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPE-------PFGTSC 211
Cdd:cd15340    82 ASFTASVGSLF---LTAIDRYISIHRpLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNsvcsdifPLIDET 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 212 TLDWWLAQASLsgqtfvmaILFFclilptgiIVFSYVMIIFKV---------KSSTKEVSHFDARINNSH-------NLE 275
Cdd:cd15340   159 YLMFWIGVTSV--------LLLF--------IVYAYMYILWKAhhhavrmlqRGTQKSIIVYTSEDGKVQttrpdqtRMD 222
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2116730773 276 MKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIY 334
Cdd:cd15340   223 IRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIY 281
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
69-331 1.97e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 39.90  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMsatGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGS 148
Cdd:cd15123    11 ISVGIL---GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 149 LITMTMVSLDRYLKICHlryGTWLKRHHAFL--CL--VFVWVYAAFWATMPLIGWGNYA---PEPFGT--SCTlDWWLAQ 219
Cdd:cd15123    88 VFTLTVLSADRYRAIVK---PLELQTSDAVLktCCkaGCVWIVSMLFAIPEAVFSDLYSfrdPEKNTTfeACA-PYPVSE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 220 ASLSGQTFVMAILFFcLILPTGIIVFSYVMIIFKVKSST-----KEVSHFDARINNshnlEMKLTKVAMLICAGFLIAWI 294
Cdd:cd15123   164 KILQEIHSLLCFLVF-YIIPLSIISVYYFLIARTLYKSTfnmpaEEHSHARKQIES----RKRVAKTVLVLVALFAFCWL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 295 PYAVVSVVSAFG-----EPDSVPIPVSVVPTLLAKSSAMYNP 331
Cdd:cd15123   239 PNHILYLYRSFTyhtsvDSSAFHLIATIFSRVLAFSNSCVNP 280
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
116-334 2.05e-03

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 39.76  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 116 PFFIVSSFA-HRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICHlryGTWLKRHH----AFLCLVFVWVYAAF 190
Cdd:cd15120    53 PFMAVHVLMdNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLH---PVWSRQHRtnrwASAIVLGVWISAIL 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 191 WATMPLIGWGNYAPEPFGTSCTLDW-----WLAQASLSGQTFVMAILFFC-----LILPTGIIVFSYVMIIFKVKsstke 260
Cdd:cd15120   130 LSIPYLAFRETRLDEKGKTICQNNYalstnWESAEVQASRQWIHVAMFVFrfllgFLLPFLIITFCYVRMALKMK----- 204
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2116730773 261 vshfDARINNSHnlemKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKS-SAMYNPIIY 334
Cdd:cd15120   205 ----ERGLARSS----KPFKVMFTAVVSFFVCWLPYHLHSGLVLTRGRPPSLTDITLLLTVGTTCfNTCFTPVLY 271
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
69-302 2.52e-03

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 39.37  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  69 LSVGIMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgKPFFIVSSfAHRWLFGWEGCQ---------FYGw 139
Cdd:cd15177     8 LVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLT-LPFAAAET-LQGWIFGNAMCKliqglyainFYS- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 aGFFFgcgslitMTMVSLDRYLKI------CHLRYGTwlkRHHAFLCLVFVWVYAAFWAtMPLIGWGNYAPEPFGTSCTL 213
Cdd:cd15177    85 -GFLF-------LTCISVDRYVVIvratsaHRLRPKT---LFYSVLTSLIVWLLSILFA-LPQLIYSRVENRSELSSCRM 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 214 DW--WLAQASLSGQTFVMAILFFCliLPTGIIVFSYVMIIFKVksstkevshFDARINNSHnlemKLTKVAMLICAGFLI 291
Cdd:cd15177   153 IFpeVVSRTVKGATALTQVVLGFA--IPLIVMAVCYAAIGRTL---------LAARGWERH----RALRVIAALVVAFVL 217
                         250
                  ....*....|.
gi 2116730773 292 AWIPYAVVSVV 302
Cdd:cd15177   218 FQLPYSVVLLL 228
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
79-284 2.57e-03

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 39.12  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTgkpFFIVSS----FAHRWLFGWEGCQFYGWAGFFFGCGSLITMTM 154
Cdd:pfam10328  11 NLLVFIAFLKLPSLKNSFGILCLSQAIGNAIICLI---FLFYVVpmtlFQNSFLPEWLNSHIIGLIAMGLYEISPLSHLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPligwgnYAPEPFGTSCTLDWWLAQASLSGQTFVMAILF 233
Cdd:pfam10328  88 IALNRFCAVFFpLKYEKIFSIKNTKIIIIFIWIVSIIFCTVF------YEPEGCHFYYNPETLTWSFEDTPCCDFITWYL 161
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 234 -FCLILPTGIIVFSY-VMIIFKVKSSTKEVSHFDARINNSHNLEMKLTKVAML 284
Cdd:pfam10328 162 dFYKNLSLVIITLFLnLLTAIKLRVSKKKSNTSSSESKRRRKREINFFKQTCF 214
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
78-336 3.25e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 39.05  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSF-AHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVS 156
Cdd:cd15308    17 GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFqGGVWTLSPVLCDALMTMDVMLCTASIFNLCAIS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 157 LDRYLKIC-HLRYGTWLKRHHAFLCLVFVWVYAAFWATmPLIGWGNYAPEPFGTSCTLDwwlaqaslsGQTFVMAILFFC 235
Cdd:cd15308    97 VDRFIAVSvPLNYNRRQGSVRQLLLISATWILSFAVAS-PVIFGLNNVPNRDPAVCKLE---------DNNYVVYSSVCS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 236 LILPTGIIVFSYVMIIFKVKSstkevshfdarinnshnlEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPDSVPIPV 315
Cdd:cd15308   167 FFIPCPVMLVLYCAMFRGLGR------------------ERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQL 228
                         250       260
                  ....*....|....*....|.
gi 2116730773 316 SVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15308   229 ISIVTWLGYVNSALNPVIYTV 249
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
73-360 3.37e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 39.04  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIK-RKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15097    12 LLGTVGNSLVLAVLLRsGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATmPLIGWGNYAPEPFGTSCTLDWWLA-QASLSGQTFVm 229
Cdd:cd15097    92 LAAVSVDRYLAIRYpLRSRELRTPRNAVAAIALIWGLSLLFAG-PYLSYYDLIDYANSTVCMPGWEEArRKAMDTCTFA- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 230 ailfFCLILPTGIIVFSYVMIIFKVKSSTKEVSHFDArinnSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEPD 309
Cdd:cd15097   170 ----FGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSE----SKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFP 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2116730773 310 SVPIPVS--VVPTLLAKSSAMYNPIIYQVVDlknscaksscfkvlkkrRHFRK 360
Cdd:cd15097   242 FNQATYAfrLLSHCMAYANSCLNPIVYALVS-----------------KHFRK 277
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
73-336 3.62e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 38.66  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITM 152
Cdd:cd15008    11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 153 TMVSLDRYLKICH-LRYGtwLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYApepfGTSCtlDWWLAQaSLSGQTFVMAI 231
Cdd:cd15008    91 LSICVDRFYTIVYpLSFK--VSREKAKKMIAASWLFDAAFVSPALFFYGSNW----GPHC--NFFLPD-SWDGAAYAIIH 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 232 LFFCLILPTGIIVFSY---VMIIFKVKSSTKEVSHfdaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAFGEP 308
Cdd:cd15008   162 LLVGFLVPSILIILFYqkvIKYIWRIGTDGRTVRR---TMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHPRESD 238
                         250       260
                  ....*....|....*....|....*...
gi 2116730773 309 DSVPIPVSVVPTLLAKSSAMYNPIIYQV 336
Cdd:cd15008   239 YRQSSLVFLAVTWISFSSSASKPTLYSV 266
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
78-260 3.82e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 38.58  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISVtgkpFFIVSSFAH----RWLFGWEGCQFYGWAGFFFGCGSLITMT 153
Cdd:cd15012    16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGI----FCVLQNLSIylipSWPFGEVLCRMYQFVHSLSYTASIGILV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 154 MVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNY-APEPFGTSCTLDWWLAQASLSGQTFVMAI 231
Cdd:cd15012    92 VISVERYIAILHpLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVeILVTQDGQEEEICVLDREMFNSKLYDTIN 171
                         170       180       190
                  ....*....|....*....|....*....|
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKV-KSSTKE 260
Cdd:cd15012   172 FIVWYLIPLLIMTVLYSKISIVLwKSSSIE 201
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
102-188 4.51e-03

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 38.36  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGC--QFYgwagFFFGCG---SLITMTMvSLDRYLKICH-LRYGTWLKRH 175
Cdd:cd15235    42 HLSLVDICFTSTTVPKMLANLLSGSKTISYAGClaQMY----FFIAFGntdSFLLAVM-AYDRYVAICHpLHYATVMSPK 116
                          90
                  ....*....|...
gi 2116730773 176 HAFLCLVFVWVYA 188
Cdd:cd15235   117 RCLLLVAGSWLLS 129
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
73-192 4.74e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 38.31  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  73 IMSATGNgYVIYMTIKRKTKLKPPE-LMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLIT 151
Cdd:cd15938    12 TMVLVGN-LLIMVTVRSDPKLSSPMyFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2116730773 152 MTMVSLDRYLKICH-LRYGTWLKRHhafLCLVFVwvyAAFWA 192
Cdd:cd15938    91 LTVMAYDRYVAICKpLHYTTIMSRR---LCWVLV---AASWA 126
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
66-340 5.03e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 38.52  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  66 LLDLSVGIMsatGNGYVIYMTIKRKTKLKPPELMTVNLAIFDFGISV-TGKPFFIVSSFA-HRWLFGWEGCQFYGWAGFF 143
Cdd:cd14995     8 LLICGVGIV---GNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVaAGLPNEIESLLGpDSWIYGYAGCLLITYLQYL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 144 FGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWaTMPLIGWGNYAPEPFG--TSCTLDWWLAQA 220
Cdd:cd14995    85 GINASSLSITAFTIERYIAICHpMKAQFICTVSRAKKIICFVWIFTSLY-CSPWLFLLDLSIKHYGddIVVRCGYKVSRH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 221 SLSGQTFVMAILFFclILPTGIIVFSYVMIIFKVKSSTKEVshfdarinnshnlemklTKVAMLICAGFLIAWIPYAVVS 300
Cdd:cd14995   164 YYLPIYLADFVLFY--VIPLLLAIVLYGLIGRILFSSRKQV-----------------TKMLAVVVVLFALLWMPYRTLV 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2116730773 301 VVSAF-GEPDSVPIPVSVVPTLLAKSSAMyNPIIYQVVDLK 340
Cdd:cd14995   225 VYNSFaSPPYLDLWFLLFCRTCIYLNSAI-NPILYNLMSQK 264
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
79-305 5.26e-03

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 38.20  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  79 NGYVIYMTIKRKTKLKPPELMTVNLAIFDFgISVTGKPFFIVS-SFAHRWLFGWEGCQFygwAGFFFGC---GSLITMTM 154
Cdd:cd16001    18 NGTVLWLSWCRTKRWTCSTIYLVNLAVADL-LYVCSLPLLIVNyAMRDRWPFGDFLCKL---VRFLFYTnlyGSILFLTC 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 155 VSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIgwgnYAPEPFGTSCTLDWWLAQASLSGQTFV--MAI 231
Cdd:cd16001    94 ISVHRFLGVCYpIRSLAYRTRRLAVIGSAATWILVVLQLLPTLV----YARTGSINNRTVCYDLTSPDNFGNYFPygMVL 169
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2116730773 232 LFFCLILPTGIIVFSYVMIIFKVKSSTKevshfdaRINNSHNLEMKLTKVAMLICAGFLIAWIPYAVVSVVSAF 305
Cdd:cd16001   170 TVTGFLIPFLIILLCYCLMIKSLIRSEE-------AAGVGKAARAKSIRTILLVCGLFALCFVPFHITRTIYLF 236
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
78-302 5.55e-03

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 38.14  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  78 GNGYVIYMTIKRKTKL-KPPELMTVNLAIFDFGISVTGKPFFIVSSFAHRWLFGWEGCQFygwAGFFFGC---GSLITMT 153
Cdd:cd15376    17 GNGLALWLFVTRERRPwHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKL---ERFLFTCnlyGSIFFIT 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 154 MVSLDRYLKICHLRYG-TWLKRHHAFLCLVFVWVYAAFwATMPLIGWGNYAPEPFGtsCTLDWWLAQASLSGQTFVMAIL 232
Cdd:cd15376    94 CISLNRYLGIVHPFFTrSHVRPKHAKLVSLAVWLLVAA-LSAPVLSFSHLEVERHN--KTECLGTAVDSRLPTYLPYSLF 170
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2116730773 233 FFCL--ILPTGIIVFSYVMIIFKVKSstkevshfdarinnSHNLEM--KLtKVAMLICAGFL---IAWIPYAVVSVV 302
Cdd:cd15376   171 LAVVgcGLPFLLTLASYLAIVWAVLR--------------SPGITTleKR-KVAALVAVVVAlyaVSFVPYHILRNL 232
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
134-214 6.43e-03

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 38.22  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 134 CQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWGNYAPEPFGTSCT 212
Cdd:cd15139    82 CGYFGFAMTFFSLATMLILLAMALERCLSIGHpYFYERYVSKRCGYVTIPLIYLLCALFCLFPFLGFGKYVQYCPGTWCF 161

                  ..
gi 2116730773 213 LD 214
Cdd:cd15139   162 ID 163
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
76-337 7.73e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 37.92  E-value: 7.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773  76 ATGNGYVIYMTIKRKTKLKPPELM---TVNLAIFDFGISVTGKPFFIVSS--FAHRWLFGWEGCQFYGWAGFFFGCGSLI 150
Cdd:cd15356    15 AAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFvwFHYPWVFGDLVCRGYYFVRDICSYATVL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 151 TMTMVSLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWA-TMPLIGWGNY-------APEPFGTSCTLdwWLAQAS 221
Cdd:cd15356    95 NIASLSAERYLAICQpLRAKRLLSKRRTKWLLALIWASSLGFAlPMAFIMGQKYeletadgEPEPSSRVCTV--LVSRAT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 222 LsgQTFVMAILFFCLILPTGIIVFSYVMIifkvksstkeVSHFDARiNNSHNLEMKLTKVAMlicagFLIAWIPYAVVSV 301
Cdd:cd15356   173 L--KVFIQVNAFVSFVLPLALIAFLNGVT----------VSHLRIQ-SLQHSVQVLRAIVIA-----YVICWLPYHARRL 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2116730773 302 VSAFGEPDSVPIPV--------SVVPTLLAKSSAMyNPIIYQVV 337
Cdd:cd15356   235 MFCYVPDDAWTDSLynfyhyfyMLTNTLFYVSSAV-NPLLYNVV 277
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
102-186 7.86e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 37.82  E-value: 7.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 102 NLAIFD--FGISVtgkPFFIVSSFAHRWLFGWEGCQFYGWAGFFFGCGSLITMTMVSLDRYLKICH-LRYGTWLKRHHAF 178
Cdd:cd15154    41 NLALSDllFTLSL---PLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHpLRFRHLRRPKVAR 117

                  ....*...
gi 2116730773 179 LCLVFVWV 186
Cdd:cd15154   118 LLCLAVWA 125
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
140-334 8.00e-03

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 37.55  E-value: 8.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 140 AGFFFGCGSLITMTmvsLDRYLKICH-LRYGTWLKRHHAFLCLVFVWVYAAFWATMPLIGWgNYAPEPfgTSCTLDWWLA 218
Cdd:cd15963    78 PSFTASVSSLLAIT---IDRYLSLYNaLTYYSERTVTRTYIMLILTWGASLCLGLLPVVGW-NCLKDP--STCSVVKPLT 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116730773 219 QASLSgqtfVMAILFFCLIlptGIIVFSYVMIIFKVKSSTKEVSHFDARINNSHNLEM-KLTKVAMLICAGFLIAWIPYA 297
Cdd:cd15963   152 KNHLV----ILSISFFMVF---ALMLQLYAQICRIVCRHAHQIALQRHFLPTSHYVTTrKGIATLAVILGTFASCWLPFA 224
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2116730773 298 VVSVVSAFGEPdsvpiPVSVVPTLL-AKSSAMYNPIIY 334
Cdd:cd15963   225 VYCLLGDYTYP-----ALYTYATLLpATYNSMINPIIY 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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