importin-beta family protein contains HEAT repeats and may bind and transport cargo by itself, or can form heterodimers with importin-alpha; importin-beta mediates interactions with the pore complex
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
24-90
3.90e-16
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
:
Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 73.82 E-value: 3.90e-16
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
914-969
7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
:
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.50 E-value: 7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
673-724
5.10e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
:
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.19 E-value: 5.10e-03
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
24-90
3.90e-16
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 73.82 E-value: 3.90e-16
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
914-969
7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.50 E-value: 7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
362-417
3.61e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.58 E-value: 3.61e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
673-724
5.10e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.19 E-value: 5.10e-03
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
24-90
3.90e-16
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 73.82 E-value: 3.90e-16
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
914-969
7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.50 E-value: 7.62e-04
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
362-417
3.61e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.58 E-value: 3.61e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
673-724
5.10e-03
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 36.19 E-value: 5.10e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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