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Conserved domains on  [gi|2106675978|ref|XP_043963377|]
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mediator of RNA polymerase II transcription subunit 23 [Gambusia affinis]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 5-1216 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1967.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978    5 METQLQSIFEDVVKTEMIEEAFAGMFMDTPENERTKLISCLGAFRQYWGTLQQDSHEQCVQWIVRFIHSQHSPKRISFLY 84
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978   85 DCLAMAVETSLLPPRML--------------------------------------------------------------- 101
Cdd:pfam11573   81 QLLEYAVQKGIISARLVceglimseklvlcnrlfwqecfklirkiipgvdykgvreilkyclekarrlpyslspekvpql 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  102 -----------------------------------------LGSLISDFVDSFRPTARINSICGRCSLLPVVNNSG---A 137
Cdd:pfam11573  161 ralenvilyildrnacllpayfivneimkgypdakmwphwrLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  138 ICNSWKLDPTTLRFPLRGMLPYDKDLFEPQTGLLRYVLEQPYSREMVCNMLGLNKQtlniaqQKQRCPVLEEQLVDLVVY 217
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  218 AMERSETEEhfdaDIGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNA 297
Cdd:pfam11573  315 AMERSETEP----EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNP 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  298 LADFLPVMKLFDLLYPEKECIPVPDISKPQSTHSFAMTCIWIHLNRKAQNDNSKLQILIPHSLKLHHEFLQQ-SLRNKSL 376
Cdd:pfam11573  391 LSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSP 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  377 GM---SDYKIALLCNAYSTNSDCFSLPMGVLVETIYGNGSMrinlPGTSCMASGSVTPLPMNLLDSLTVHAKMSLIHSIA 453
Cdd:pfam11573  471 NLamgSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIV 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  454 TRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL 533
Cdd:pfam11573  547 THVIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLL 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  534 SHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVL-SAESEELNRALILTLARATHVTdfftG 612
Cdd:pfam11573  627 SHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----G 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  613 SDSIHGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQ 692
Cdd:pfam11573  703 TGTDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVP 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  693 GSPPLFLCLLWKMLLETDRINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLD 772
Cdd:pfam11573  783 GTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTID 862

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  773 RLILCLAMRSHEGNEAQVCYFIIQLLLLKPSDFRNRVNDFVKENAPEHWLQSDWHNKHMNYHKKYPEKLYFEGLAEQVSP 852
Cdd:pfam11573  863 RLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  853 plqlQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLK 932
Cdd:pfam11573  943 ----SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLK 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  933 RKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAH 1012
Cdd:pfam11573 1019 RKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAH 1098

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1013 ALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIISVLSSPALTSETEW 1092
Cdd:pfam11573 1099 ALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP 1178

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1093 aGDPFALLDFTACHQSYSEMNCSYVLALTHAVWHHSSIGQLSLIPKFLSETLKPIVQTELQLLYVYHLVGPFLQRFQQER 1172
Cdd:pfam11573 1179 -CSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAER 1257

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 2106675978 1173 TRCMLEIGVAFYEMLQAVDQHCQHLSYMDPICDFLYHIKYMYTG 1216
Cdd:pfam11573 1258 ERGVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 5-1216 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1967.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978    5 METQLQSIFEDVVKTEMIEEAFAGMFMDTPENERTKLISCLGAFRQYWGTLQQDSHEQCVQWIVRFIHSQHSPKRISFLY 84
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978   85 DCLAMAVETSLLPPRML--------------------------------------------------------------- 101
Cdd:pfam11573   81 QLLEYAVQKGIISARLVceglimseklvlcnrlfwqecfklirkiipgvdykgvreilkyclekarrlpyslspekvpql 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  102 -----------------------------------------LGSLISDFVDSFRPTARINSICGRCSLLPVVNNSG---A 137
Cdd:pfam11573  161 ralenvilyildrnacllpayfivneimkgypdakmwphwrLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  138 ICNSWKLDPTTLRFPLRGMLPYDKDLFEPQTGLLRYVLEQPYSREMVCNMLGLNKQtlniaqQKQRCPVLEEQLVDLVVY 217
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  218 AMERSETEEhfdaDIGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNA 297
Cdd:pfam11573  315 AMERSETEP----EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNP 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  298 LADFLPVMKLFDLLYPEKECIPVPDISKPQSTHSFAMTCIWIHLNRKAQNDNSKLQILIPHSLKLHHEFLQQ-SLRNKSL 376
Cdd:pfam11573  391 LSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSP 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  377 GM---SDYKIALLCNAYSTNSDCFSLPMGVLVETIYGNGSMrinlPGTSCMASGSVTPLPMNLLDSLTVHAKMSLIHSIA 453
Cdd:pfam11573  471 NLamgSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIV 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  454 TRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL 533
Cdd:pfam11573  547 THVIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLL 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  534 SHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVL-SAESEELNRALILTLARATHVTdfftG 612
Cdd:pfam11573  627 SHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----G 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  613 SDSIHGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQ 692
Cdd:pfam11573  703 TGTDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVP 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  693 GSPPLFLCLLWKMLLETDRINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLD 772
Cdd:pfam11573  783 GTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTID 862

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  773 RLILCLAMRSHEGNEAQVCYFIIQLLLLKPSDFRNRVNDFVKENAPEHWLQSDWHNKHMNYHKKYPEKLYFEGLAEQVSP 852
Cdd:pfam11573  863 RLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  853 plqlQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLK 932
Cdd:pfam11573  943 ----SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLK 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  933 RKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAH 1012
Cdd:pfam11573 1019 RKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAH 1098

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1013 ALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIISVLSSPALTSETEW 1092
Cdd:pfam11573 1099 ALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP 1178

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1093 aGDPFALLDFTACHQSYSEMNCSYVLALTHAVWHHSSIGQLSLIPKFLSETLKPIVQTELQLLYVYHLVGPFLQRFQQER 1172
Cdd:pfam11573 1179 -CSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAER 1257

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 2106675978 1173 TRCMLEIGVAFYEMLQAVDQHCQHLSYMDPICDFLYHIKYMYTG 1216
Cdd:pfam11573 1258 ERGVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 5-1216 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1967.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978    5 METQLQSIFEDVVKTEMIEEAFAGMFMDTPENERTKLISCLGAFRQYWGTLQQDSHEQCVQWIVRFIHSQHSPKRISFLY 84
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978   85 DCLAMAVETSLLPPRML--------------------------------------------------------------- 101
Cdd:pfam11573   81 QLLEYAVQKGIISARLVceglimseklvlcnrlfwqecfklirkiipgvdykgvreilkyclekarrlpyslspekvpql 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  102 -----------------------------------------LGSLISDFVDSFRPTARINSICGRCSLLPVVNNSG---A 137
Cdd:pfam11573  161 ralenvilyildrnacllpayfivneimkgypdakmwphwrLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  138 ICNSWKLDPTTLRFPLRGMLPYDKDLFEPQTGLLRYVLEQPYSREMVCNMLGLNKQtlniaqQKQRCPVLEEQLVDLVVY 217
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  218 AMERSETEEhfdaDIGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNA 297
Cdd:pfam11573  315 AMERSETEP----EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNP 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  298 LADFLPVMKLFDLLYPEKECIPVPDISKPQSTHSFAMTCIWIHLNRKAQNDNSKLQILIPHSLKLHHEFLQQ-SLRNKSL 376
Cdd:pfam11573  391 LSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSP 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  377 GM---SDYKIALLCNAYSTNSDCFSLPMGVLVETIYGNGSMrinlPGTSCMASGSVTPLPMNLLDSLTVHAKMSLIHSIA 453
Cdd:pfam11573  471 NLamgSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIV 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  454 TRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLL 533
Cdd:pfam11573  547 THVIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLL 626

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  534 SHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVL-SAESEELNRALILTLARATHVTdfftG 612
Cdd:pfam11573  627 SHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----G 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  613 SDSIHGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQ 692
Cdd:pfam11573  703 TGTDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVP 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  693 GSPPLFLCLLWKMLLETDRINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLD 772
Cdd:pfam11573  783 GTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTID 862

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  773 RLILCLAMRSHEGNEAQVCYFIIQLLLLKPSDFRNRVNDFVKENAPEHWLQSDWHNKHMNYHKKYPEKLYFEGLAEQVSP 852
Cdd:pfam11573  863 RLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  853 plqlQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLK 932
Cdd:pfam11573  943 ----SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLK 1018

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978  933 RKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAH 1012
Cdd:pfam11573 1019 RKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAH 1098

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1013 ALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIISVLSSPALTSETEW 1092
Cdd:pfam11573 1099 ALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP 1178

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2106675978 1093 aGDPFALLDFTACHQSYSEMNCSYVLALTHAVWHHSSIGQLSLIPKFLSETLKPIVQTELQLLYVYHLVGPFLQRFQQER 1172
Cdd:pfam11573 1179 -CSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAER 1257

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 2106675978 1173 TRCMLEIGVAFYEMLQAVDQHCQHLSYMDPICDFLYHIKYMYTG 1216
Cdd:pfam11573 1258 ERGVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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