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Conserved domains on  [gi|2104885332|gb|UBU20553|]
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galactokinase [Blautia parvula]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
36-426 4.75e-123

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 361.78  E-value: 4.75e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  36 RYKKAIEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGY-EMVDVDVNDL 114
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFdEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 115 EerYDEEGTTAALVRGVAAELKARGYEVQGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYA 194
Cdd:COG0153    81 E--PGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-LDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 195 ENVYFGKPCGLMDQMACSVGGMIHIDFKEPGSPVVEKVPSDFEsyQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFG 274
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 275 KTYLREVEEDDFykqiSGLRSVLGDRPI-LRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSSFKYLQniyNSTN 353
Cdd:COG0153   236 VKSLRDVTLEDL----EAARARLGDEVLrRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYE---VSCP 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104885332 354 VQKQAMSIALAVSDkilrkHGVSRVHGGGFAGTIEIFVENSFVDEYKARMDRVFGKGS---CQILKVRQSGGRRVL 426
Cdd:COG0153   309 ELDTLVELALAEAG-----VLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTglePDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
36-426 4.75e-123

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 361.78  E-value: 4.75e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  36 RYKKAIEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGY-EMVDVDVNDL 114
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFdEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 115 EerYDEEGTTAALVRGVAAELKARGYEVQGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYA 194
Cdd:COG0153    81 E--PGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-LDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 195 ENVYFGKPCGLMDQMACSVGGMIHIDFKEPGSPVVEKVPSDFEsyQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFG 274
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 275 KTYLREVEEDDFykqiSGLRSVLGDRPI-LRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSSFKYLQniyNSTN 353
Cdd:COG0153   236 VKSLRDVTLEDL----EAARARLGDEVLrRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYE---VSCP 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104885332 354 VQKQAMSIALAVSDkilrkHGVSRVHGGGFAGTIEIFVENSFVDEYKARMDRVFGKGS---CQILKVRQSGGRRVL 426
Cdd:COG0153   309 ELDTLVELALAEAG-----VLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTglePDFYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 39-400 3.99e-37

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 139.19  E-value: 3.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  39 KAIEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYEM-VDVDVNDLEER 117
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNkFAERSLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 118 YDEEGTTAALVRGVAAELKARGYEV-QGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFnEGSIDPVVIAQTGQYAEN 196
Cdd:TIGR00131  83 GSEVSDWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMG-HLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 197 VYFGKPCGLMDQMACSVGGMIH---IDFKEpgspvVEKVPSDFESYQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFF 273
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHallVECRS-----LKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 274 GKTY---LREVEEDDFYKQISGLRSVLgdrPIL--RALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNI 348
Cdd:TIGR00131 237 AATDkgaLRDFMNEYFARYIARLTKML---PLVeeRAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHAS----CDDD 309

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2104885332 349 YNSTNVQ--KQAMSIALAVSDkilrkhGVSRVHGGGFAGTIEIFVENSFVDEYK 400
Cdd:TIGR00131 310 YECTCPEidELVCSAALVNGS------GGSRMTGAGFGGCTVHLVPNENVDKVR 357
PRK05322 PRK05322
galactokinase; Provisional
 41-402 1.97e-36

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 137.30  E-value: 1.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  41 IEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYE---MVDVDVNDLeeR 117
Cdd:PRK05322    7 KKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEdlgIIEFDLDDL--S 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 118 YDEEGTTAALVRGVAAELKARGYEV-QGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYAEN 196
Cdd:PRK05322   85 FDKEDDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLD-LDRLELVKLGQKTEN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 197 VYFGKPCGLMDQMACSVGGMIHIDFKEPGSPVVEKVPSDFESyqYSMCIVDTKASHADMGDDY----ASIPEEMKKVAKF 272
Cdd:PRK05322  164 EFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGD--YVIVIMNTNKRRELADSKYnerrAECEKALEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 273 FGKTYLREVEEDDFYKqisgLRSVLGDRPIL-RALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNIYNS 351
Cdd:PRK05322  242 LDIKSLGELTEEEFDE----YSYLIKDETLLkRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVS----LRDDYEV 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2104885332 352 TNVQKQAMsIALAvsdkiLRKHGV--SRVHGGGFAG-TIEIfVENSFVDEYKAR 402
Cdd:PRK05322  314 TGLELDTL-VEAA-----WKQEGVlgARMTGAGFGGcAIAI-VKKDKVEAFKEN 360
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 42-91 1.74e-17

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 75.57  E-value: 1.74e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2104885332  42 EEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGR 91
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
36-426 4.75e-123

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 361.78  E-value: 4.75e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  36 RYKKAIEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGY-EMVDVDVNDL 114
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFdEEVEFDLDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 115 EerYDEEGTTAALVRGVAAELKARGYEVQGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYA 194
Cdd:COG0153    81 E--PGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-LDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 195 ENVYFGKPCGLMDQMACSVGGMIHIDFKEPGSPVVEKVPSDFEsyQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFG 274
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 275 KTYLREVEEDDFykqiSGLRSVLGDRPI-LRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSSFKYLQniyNSTN 353
Cdd:COG0153   236 VKSLRDVTLEDL----EAARARLGDEVLrRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYE---VSCP 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2104885332 354 VQKQAMSIALAVSDkilrkHGVSRVHGGGFAGTIEIFVENSFVDEYKARMDRVFGKGS---CQILKVRQSGGRRVL 426
Cdd:COG0153   309 ELDTLVELALAEAG-----VLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTglePDFYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 39-400 3.99e-37

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 139.19  E-value: 3.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  39 KAIEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYEM-VDVDVNDLEER 117
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNkFAERSLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 118 YDEEGTTAALVRGVAAELKARGYEV-QGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFnEGSIDPVVIAQTGQYAEN 196
Cdd:TIGR00131  83 GSEVSDWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMG-HLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 197 VYFGKPCGLMDQMACSVGGMIH---IDFKEpgspvVEKVPSDFESYQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFF 273
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHallVECRS-----LKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 274 GKTY---LREVEEDDFYKQISGLRSVLgdrPIL--RALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNI 348
Cdd:TIGR00131 237 AATDkgaLRDFMNEYFARYIARLTKML---PLVeeRAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHAS----CDDD 309

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2104885332 349 YNSTNVQ--KQAMSIALAVSDkilrkhGVSRVHGGGFAGTIEIFVENSFVDEYK 400
Cdd:TIGR00131 310 YECTCPEidELVCSAALVNGS------GGSRMTGAGFGGCTVHLVPNENVDKVR 357
PRK05322 PRK05322
galactokinase; Provisional
 41-402 1.97e-36

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 137.30  E-value: 1.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  41 IEEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYE---MVDVDVNDLeeR 117
Cdd:PRK05322    7 KKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEdlgIIEFDLDDL--S 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 118 YDEEGTTAALVRGVAAELKARGYEV-QGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYAEN 196
Cdd:PRK05322   85 FDKEDDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLD-LDRLELVKLGQKTEN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 197 VYFGKPCGLMDQMACSVGGMIHIDFKEPGSPVVEKVPSDFESyqYSMCIVDTKASHADMGDDY----ASIPEEMKKVAKF 272
Cdd:PRK05322  164 EFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGD--YVIVIMNTNKRRELADSKYnerrAECEKALEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 273 FGKTYLREVEEDDFYKqisgLRSVLGDRPIL-RALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNIYNS 351
Cdd:PRK05322  242 LDIKSLGELTEEEFDE----YSYLIKDETLLkRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVS----LRDDYEV 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2104885332 352 TNVQKQAMsIALAvsdkiLRKHGV--SRVHGGGFAG-TIEIfVENSFVDEYKAR 402
Cdd:PRK05322  314 TGLELDTL-VEAA-----WKQEGVlgARMTGAGFGGcAIAI-VKKDKVEAFKEN 360
PRK05101 PRK05101
galactokinase; Provisional
 44-401 6.86e-35

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 133.12  E-value: 6.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  44 FEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSIN-QDALAVVGRsEDGMIHVLSDGYEMvDVDVNDLEE--RYDE 120
Cdd:PRK05101   11 FAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDyQTVISCAKR-DDRIVRVIAADYDN-QQDEFSLDApiVPHP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 121 EGTTAALVRGVAAELKARGYEVQGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYAENVYFG 200
Cdd:PRK05101   89 EQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLP-LSGAEIALNGQEAENQFVG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 201 KPCGLMDQMACSVGGMIH---IDFKEPGSPVVeKVPSDfesyqYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFGKTY 277
Cdd:PRK05101  168 CNCGIMDQLISALGKKDHallIDCRSLETKAV-PMPEG-----VAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVKA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 278 LREVEEDDFYKQISGLRSVLGDrpilRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNIYNSTNVQkq 357
Cdd:PRK05101  242 LRDVTLEQFNAVAAELDPVVAK----RARHVITENARTLEAASALAAGDLKRMGELMAESHAS----MRDDFEITVPQ-- 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2104885332 358 amsIALAVS--DKILRKHGVSRVHGGGFAGTIEIFVENSFVDEYKA 401
Cdd:PRK05101  312 ---IDTLVEivKAVIGDQGGVRMTGGGFGGCIVALVPEELVEAVRQ 354
PRK00555 PRK00555
galactokinase; Provisional
 56-397 9.91e-35

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 132.29  E-value: 9.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  56 YSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLS---DGYEMVDVDVNdleerydeEGTT---AALVR 129
Cdd:PRK00555    5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSdraDGSARIPLDTT--------PGQVtgwAAYAA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 130 GVAAELKARGYEVQGYNAYIVSDVLIGAGLSSSAAFE-VILGTIISGLFNEgsIDPVVIAQTGQYAENVYFGKPCGLMDQ 208
Cdd:PRK00555   77 GVIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALEcAVLGAVGAATGTR--IDRLEQARLAQRAENEYVGAPTGLLDQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 209 MACSVGG---MIHIDFKEPGspvVEKVPSDFESYQYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFGKTYLREVEEdd 285
Cdd:PRK00555  155 LAALFGApktALLIDFRDLT---VRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQD-- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 286 fyKQISGLRSVLGDRPILRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNIYNSTNVQkqamsIALaV 365
Cdd:PRK00555  230 --RGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHAS----MRDDFEITTER-----IDL-I 297

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2104885332 366 SDKILRKHGV-SRVHGGGFAGTIEIFVENSFVD 397
Cdd:PRK00555  298 ADSAVRAGALgARMTGGGFGGCVIALVPADRAE 330
PRK03817 PRK03817
galactokinase; Provisional
 56-426 2.73e-31

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 122.41  E-value: 2.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  56 YSAPGRCEVGGNHTDHQNGMVLATSINQdaLAVVGRSEDGMIHVLSDGY-EMVDVDVNDLEErydeEGTTAALVRGVAAE 134
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNDGYVLPFAINL--YTFLEIEKSEKFIFYSENFnEEKTFELDKLEK----LNSWADYIKGVIWV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 135 LKARGYEVQGYNAYIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsIDPVVIAQTGQYAENVYFGKPCGLMDQMACSVG 214
Cdd:PRK03817   77 LEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLN-LSKLELALLAREAENEFVGVPCGIMDQFAVAFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 215 GMIHIDFKEPGSPVVEKVPSDFEsyqYSMCIVDTKASHADMGDDYASIPEEMKKVAKFFGKTYLREVEEDDFYKQISGLR 294
Cdd:PRK03817  156 KKDHAIFLDTMTLEYEYVPFPED---YEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKLPPLLR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 295 SvlgdrpilRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSsfkyLQNIYNstnvqkqamsialaVS----DKI- 369
Cdd:PRK03817  233 K--------RAGYVLRENERVLKVRDALKEGDIETLGELLTESHWD----LADNYE--------------VSceelDFFv 286

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2104885332 370 --LRKHGV--SRVHGGGFAGTIEIFVEN----SFVDEYKARMDRVFGKgSCQILKVRQSGGRRVL 426
Cdd:PRK03817  287 efALELGAygARLTGAGFGGSAIALVDKgkfeSIGEELLEEYKKRFGI-DPKYFVVESSDGVRKI 350
PLN02865 PLN02865
galactokinase
 49-398 1.13e-18

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 87.55  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  49 GESDVEIYSAPGR-CEVGGnHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYE-MVDVDVNDLE-------ERYD 119
Cdd:PLN02865   26 NSGEVRVVVSPYRiCPLGA-HIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEgEVRFRVDEIQhpianvsSDSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 120 EEGTTAALVRGVAAELKARGYEV-QGYNAYIV-SDVLIGAGLSSSAAFEVILGTIISGLfNEGSIDPVVIAQTGQYAENV 197
Cdd:PLN02865  105 EESNWGDYARGAVYALQSRGHALsQGITGYISgSEGLDSSGLSSSAAVGVAYLLALENA-NNLTVSPEDNIELDRLIENE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 198 YFGKPCGLMDQMA---CSVGGMIHIDFKEPGSpvvEKVPSDFESYQ----YSMCIVDTKASHA-DMGDDYASIPEEMKKV 269
Cdd:PLN02865  184 YLGLRNGILDQSAillSRYGCLTFMDCKTLDH---KLVSLQFQQPGgekpFKILLAFSGLRHAlTNKPGYNLRVSECQEA 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 270 AKFF----GKTYLREVEEDDFYKQISGLRSVLGDRPILRALHFFEEERRVEGEVKALRDGDFKEFLELVKDSGNSSfkyL 345
Cdd:PLN02865  261 ARFLleasGNDELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSS---I 337

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2104885332 346 QNIYNSTNVQKQAMSIAlavsdkiLRKHGV--SRVHGGGFAGTIEIFVENSFVDE 398
Cdd:PLN02865  338 ENYECGCEPLIQLYEIL-------LKAPGVygARFSGAGFRGCCVAFVDAEMAEE 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 42-91 1.74e-17

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 75.57  E-value: 1.74e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2104885332  42 EEFEKIFGESDVEIYSAPGRCEVGGNHTDHQNGMVLATSINQDALAVVGR 91
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PLN02521 PLN02521
galactokinase
 20-221 8.20e-13

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 69.74  E-value: 8.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  20 LKEIYVDESVLDYQRKRYKKAIEEFEKIFGeSDVEIYS-APGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSE-DGMI 97
Cdd:PLN02521   15 LEPVYGDGSLLEEARLRYARLKAAFVEVYG-AKPDLFArSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  98 HV--LSDGYEMVDVDVNDleeryDEEGTTAALV---------RGVAAELKARGYEVQ---GYNAYIVSDVLIGAGLSSSA 163
Cdd:PLN02521   94 RIanVNDKYTTCTFPADP-----DQEVDLANHKwgnyficgyKGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSA 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2104885332 164 AFeVILGTI-ISGLFNEgSIDPVVIAQTGQYAENvYFGKPCGLMDQmACSVGGMI----HIDF 221
Cdd:PLN02521  169 AL-VCSAAIaIMAALGL-NFTKKEVAQFTCKCER-HIGTQSGGMDQ-AISIMAQQgvakLIDF 227
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 58-364 1.16e-12

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 67.95  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  58 APGRCEVGGNHTDHQNGMVLATSINQDALAVVGRSEDGMIHVLSDGYEmvdvdvNDLEERYDEEGTTAALVRGVAAELKA 137
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLG------GTLDLDPLADAALRYIKAAIEAALEY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 138 RGYEVQGYNAYIVSDVLIGAGLSSSAAfeVILGTI--ISGLFNEgSIDPVVIAQTGQYAENVYFGKPCGlMDQMACSVGG 215
Cdd:COG1577    75 LGLPLKGFDIEIDSEIPRKRGLGSSAA--VAVAVIraLAAFYGV-ELSKEELFKLALEAEKIVHGNPSG-LDTAASTYGG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332 216 MIHIDFKEPGSPVveKVPSDFesyqySMCIVDTKAShadmgddyASIPEEMKKVAKFFGKtylREVEEDDFYKQISGLrs 295
Cdd:COG1577   151 PIYYQRGDRAEPL--ELPKNL-----PLVVGDTGVP--------ASTKELVAKVRKLKER---NPELYEAFLEEIGDL-- 210

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2104885332 296 vlgdrpILRALhffeeerrvegevKALRDGDFKEFLELVkdsgNSSFKYLQNIYNSTNVQKQAMSIALA 364
Cdd:COG1577   211 ------VEEAI-------------EALEEGDLEALGELM----NENHGLLRALGVSTPELDRLVEAARK 256
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 148-215 1.58e-08

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 51.01  E-value: 1.58e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2104885332 148 YIVSDVLIGAGLSSSAAFEVILGTIISGLFNEGsidpvvIAQTGQYAENVYFGKPCGLMDQMACSVGG 215
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLP------LAKLALEAEELAGGGRGGGMDVAASLYGG 64
PTZ00290 PTZ00290
galactokinase; Provisional
 30-210 4.74e-06

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 48.67  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  30 LDYQRKRYKKAIEEFEKIF-------GESDVE--IYS-APGRCEVGGNHTDHQNGMVLATSINQDALAVVGRS---EDGM 96
Cdd:PTZ00290    4 ESYSDERLDSTLSTLKPIFletfkveNDADVEwlLFTfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVkhfCDHK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2104885332  97 IHVLSDGYEMVDVDvNDLEERYDEEGTTaaLVRGVAA-ELKARGY-----EVQGYNAYIVSDVLIGAGLSSSAAFEVIL- 169
Cdd:PTZ00290   84 LRFATETDEHFVLD-HLGGAKHNKAWTT--FVRGAATlRLNRLGVaidapSLQGVCMVVHGTLPMGAGMSASASFGVALl 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2104885332 170 ---GTIISGLFNEGSIDP---------------VVIAQTGQYAENVYFGKPCGLMDQMA 210
Cdd:PTZ00290  161 naiNTVVTRRYKGCPTSPgrrysilppmskeelIELAKQARRIETEFCGVNVGIMDQFI 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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