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Conserved domains on  [gi|2103685789|ref|WP_224224424|]
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biotin/lipoyl-containing protein, partial [Klebsiella variicola]

Protein Classification

acetyl-CoA carboxylase biotin carboxylase subunit family protein( domain architecture ID 1562446)

acetyl-CoA carboxylase biotin carboxylase subunit family protein similar to Bacillus subtilis alanine--anticapsin ligase that is part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, and to the biotin-containing subunit of transcarboxylase from Propionibacterium shermanii

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12999 super family cl39082
pyruvate carboxylase; Reviewed
 1-180 2.10e-93

pyruvate carboxylase; Reviewed


The actual alignment was detected with superfamily member PRK14040:

Pssm-ID: 476865 [Multi-domain]  Cd Length: 593  Bit Score: 282.98  E-value: 2.10e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   1 DGADPVTCRPADLLKPELAQLEADVRRQAQEKGITLAENAIDDVLTVALFPQPGLKFLENRHNPAAFEPVPQVEAAQPlA 80
Cdd:PRK14040  391 EGAEPITCRPADLLAPELDKLEAELRRQAQEKGITLAENAIDDVLTYALFPQIGLKFLENRHNPAAFEPVPQAEAAQP-A 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  81 KAEKPAASGVYTVEVEGKAFVVKVSDGGDVSQL---SAAPVAAAPAAAPAPAGAGTPVTAPLAGTIWKVLAAEGQTVAEG 157
Cdd:PRK14040  470 AKAEPAGSETYTVEVEGKAYVVKVSEGGDISQItpaAPAAAPAAAAAAAPAAAAGEPVTAPLAGNIFKVIVTEGQTVAEG 549

                         170       180
                  ....*....|....*....|...
gi 2103685789 158 EVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK14040  550 DVLLILEAMKMETEIRAAQAGTV 572
 
Name Accession Description Interval E-value
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
1-180 2.10e-93

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 282.98  E-value: 2.10e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   1 DGADPVTCRPADLLKPELAQLEADVRRQAQEKGITLAENAIDDVLTVALFPQPGLKFLENRHNPAAFEPVPQVEAAQPlA 80
Cdd:PRK14040  391 EGAEPITCRPADLLAPELDKLEAELRRQAQEKGITLAENAIDDVLTYALFPQIGLKFLENRHNPAAFEPVPQAEAAQP-A 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  81 KAEKPAASGVYTVEVEGKAFVVKVSDGGDVSQL---SAAPVAAAPAAAPAPAGAGTPVTAPLAGTIWKVLAAEGQTVAEG 157
Cdd:PRK14040  470 AKAEPAGSETYTVEVEGKAYVVKVSEGGDISQItpaAPAAAPAAAAAAAPAAAAGEPVTAPLAGNIFKVIVTEGQTVAEG 549

                         170       180
                  ....*....|....*....|...
gi 2103685789 158 EVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK14040  550 DVLLILEAMKMETEIRAAQAGTV 572
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 135-180 5.11e-19

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 76.30  E-value: 5.11e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2103685789 135 VTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:cd06850     2 VTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVV 47
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 82-180 1.26e-17

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 74.93  E-value: 1.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  82 AEKPAASGVYTVEVEGKAFVVKVSDGGDVSQL--------SAAPVAAAPAAAPAPAGAGTPVTAPLAGTI-------WKV 146
Cdd:COG0511     2 IELLEESGLTELEVEEGEYKVRIKRGGAAAAApvaapaaaAPAAAAPAAAAAAAAASGGGAVKSPMVGTFyrapspgAKP 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2103685789 147 LAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:COG0511    82 FVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTV 115
PYC_OADA pfam02436
Conserved carboxylase domain; This domain represents a conserved region in pyruvate ...
 2-102 6.26e-14

Conserved carboxylase domain; This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (pfam00682) and often close to the biotin_lipoyl domain (pfam00364) of biotin requiring enzymes.


Pssm-ID: 460557 [Multi-domain]  Cd Length: 201  Bit Score: 66.71  E-value: 6.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   2 GADPVTCRPADLLKP-ELAQLEADVRRQAQEkgitlaENAIDDVLTVALFPQPGLKFLENRhnpAAFEPVPQVEAAQPLA 80
Cdd:pfam02436 110 GEEPITCRPGDLLPPvDLEKLRKELEEKAGR------ETTEEDVLSYALYPKVAEKFLKFR---EKYGDVSVLPTPVFFY 180

                          90       100
                  ....*....|....*....|..
gi 2103685789  81 KAEKPaasGVYTVEVEGKAFVV 102
Cdd:pfam02436 181 GLEPG---EEYEVEIEGGKYLI 199
 
Name Accession Description Interval E-value
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
1-180 2.10e-93

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 282.98  E-value: 2.10e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   1 DGADPVTCRPADLLKPELAQLEADVRRQAQEKGITLAENAIDDVLTVALFPQPGLKFLENRHNPAAFEPVPQVEAAQPlA 80
Cdd:PRK14040  391 EGAEPITCRPADLLAPELDKLEAELRRQAQEKGITLAENAIDDVLTYALFPQIGLKFLENRHNPAAFEPVPQAEAAQP-A 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  81 KAEKPAASGVYTVEVEGKAFVVKVSDGGDVSQL---SAAPVAAAPAAAPAPAGAGTPVTAPLAGTIWKVLAAEGQTVAEG 157
Cdd:PRK14040  470 AKAEPAGSETYTVEVEGKAYVVKVSEGGDISQItpaAPAAAPAAAAAAAPAAAAGEPVTAPLAGNIFKVIVTEGQTVAEG 549

                         170       180
                  ....*....|....*....|...
gi 2103685789 158 EVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK14040  550 DVLLILEAMKMETEIRAAQAGTV 572
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 4-180 1.23e-38

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 138.82  E-value: 1.23e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   4 DPVTCRPADLLKPELAQLeadvRRQAQEKGITLAEnaidDVLTVALFPQPGLKFLENRHNPAAFEPVPQVEAAQPlakaE 83
Cdd:PRK09282  393 EPITCRPADLLEPELEKA----RKEAEELGKSEKE----DVLTYALFPQIAKKFLEEREAGELKPEPEPKEAAAA----G 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  84 KPAASGVYTVEVEGKAFVVKV-------------SDGGDVSQLSAAPVAAAPAAAPAPAGAGTPVTAPLAGTIWKVLAAE 150
Cdd:PRK09282  461 AEGIPTEFKVEVDGEKYEVKIegvkaegkrpfylRVDGMPEEVVVEPLKEIVVGGRPRASAPGAVTSPMPGTVVKVKVKE 540

                         170       180       190
                  ....*....|....*....|....*....|
gi 2103685789 151 GQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK09282  541 GDKVKAGDTVLVLEAMKMENEIQAPVDGTV 570
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 135-180 5.11e-19

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 76.30  E-value: 5.11e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2103685789 135 VTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:cd06850     2 VTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVV 47
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 2-180 1.01e-18

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 82.49  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789    2 GADPVTCRPADLLKPelAQLEAdVRRQAQEKGITLAENaiDDVLTVALFPQPGLKFLENRHN---------PAAFEPV-P 71
Cdd:PRK12999   937 GEEPITVRPGELLEP--VDFEA-ERAELEEKLGREVTD--RDVLSYLLYPKVFEDYIKHREEygdvsvlptPTFFYGLrP 1011

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   72 QVEAAQPLAKAE----------KPAASGVYTV--EVEGKAFVVKVSDggdvsqlsaaPVAAAPAAAPAPAGAGTP--VTA 137
Cdd:PRK12999  1012 GEEIEVEIEPGKtliikleaigEPDEDGMRTVyfELNGQPREVQVRD----------RSVKSTVAAREKADPGNPghVGA 1081

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2103685789  138 PLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK12999  1082 PMPGSVVTVLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTV 1124
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 82-180 1.26e-17

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 74.93  E-value: 1.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  82 AEKPAASGVYTVEVEGKAFVVKVSDGGDVSQL--------SAAPVAAAPAAAPAPAGAGTPVTAPLAGTI-------WKV 146
Cdd:COG0511     2 IELLEESGLTELEVEEGEYKVRIKRGGAAAAApvaapaaaAPAAAAPAAAAAAAAASGGGAVKSPMVGTFyrapspgAKP 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2103685789 147 LAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:COG0511    82 FVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTV 115
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 2-180 1.24e-16

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 76.66  E-value: 1.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789    2 GADPVTCRPADLLKPElaQLEAdVRRQAQEK-GITLAEnaiDDVLTVALFPQPGLKFLENRHN---------PAAFEP-V 70
Cdd:COG1038    937 GRKPITVRPGELLPPV--DFDA-LRAELEEKlGREPSD---RDVLSYLLYPKVFEDYAKHREEygdvsvlptPTFFYGlR 1010

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   71 PQVEAAQPLAKAE----------KPAASGVYTV--EVEGKAFVVKVSDggdvsqlsAAPVAAAPAAAPAPAGAGTPVTAP 138
Cdd:COG1038   1011 PGEEIEVEIEEGKtliikllaigEPDEDGMRTVffELNGQPREVRVRD--------RSVKVTVASREKADPGNPGHIGAP 1082

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2103685789  139 LAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:COG1038   1083 MPGTVVKVLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTV 1124
PYC_OADA pfam02436
Conserved carboxylase domain; This domain represents a conserved region in pyruvate ...
 2-102 6.26e-14

Conserved carboxylase domain; This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (pfam00682) and often close to the biotin_lipoyl domain (pfam00364) of biotin requiring enzymes.


Pssm-ID: 460557 [Multi-domain]  Cd Length: 201  Bit Score: 66.71  E-value: 6.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   2 GADPVTCRPADLLKP-ELAQLEADVRRQAQEkgitlaENAIDDVLTVALFPQPGLKFLENRhnpAAFEPVPQVEAAQPLA 80
Cdd:pfam02436 110 GEEPITCRPGDLLPPvDLEKLRKELEEKAGR------ETTEEDVLSYALYPKVAEKFLKFR---EKYGDVSVLPTPVFFY 180

                          90       100
                  ....*....|....*....|..
gi 2103685789  81 KAEKPaasGVYTVEVEGKAFVV 102
Cdd:pfam02436 181 GLEPG---EEYEVEIEGGKYLI 199
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 135-180 2.34e-11

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 56.72  E-value: 2.34e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2103685789 135 VTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK08225    4 VYASMAGNVWKIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTV 49
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 135-180 5.12e-11

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 57.51  E-value: 5.12e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2103685789 135 VTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK06549   64 MPSPMPGTILKVLVAVGDQVTENQPLLILEAMKMENEIVASSAGTV 109
PRK12330 PRK12330
methylmalonyl-CoA carboxytransferase subunit 5S;
2-104 2.56e-10

methylmalonyl-CoA carboxytransferase subunit 5S;


Pssm-ID: 183445 [Multi-domain]  Cd Length: 499  Bit Score: 58.23  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   2 GADPVTCRPADLLKPELAQLeadvrrQAQEKGITLAENAIDDVLTVALFPQPGLKFLENRHN-PAAFEPVP-QVEAAQPL 79
Cdd:PRK12330  395 KKEPITCRPADLLEPEWDKL------RAEALALEGCDGSDEDVLTYALFPQVAPKFFATRAEgPKNVGKDPaQGAAEAAA 468

                          90       100
                  ....*....|....*....|....*..
gi 2103685789  80 AKAEKPAASG--VYTVEVEGKAFVVKV 104
Cdd:PRK12330  469 AAGHAGAITGpiTYKVTVGGRSHKVTV 495
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 89-180 5.91e-10

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 54.87  E-value: 5.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  89 GVYTVEVEGKAFVVKVSDGG-DVSQLSAAPVAAAPAAAPAPAGAGTP-----------------VTAPLAGTIWKVLAAE 150
Cdd:PRK05641   23 GKFRVSFEGKTYEVEAKGLGiDLSAVQEQVPTPAPAPAPAVPSAPTPvapaapapapasagenvVTAPMPGKILRILVRE 102

                          90       100       110
                  ....*....|....*....|....*....|
gi 2103685789 151 GQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK05641  103 GQQVKVGQGLLILEAMKMENEIPAPKDGVV 132
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 6-180 1.60e-09

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 55.88  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   6 VTCRPADLLKPELAQLEADVRRQAQEKgitlaenaiDDVLTVALFPQPGLKFLENRHNPaafEPVPQVEAAQplAKAEKP 85
Cdd:PRK14042  395 IEVRPGDLLPNELDQLQNEISDLALSD---------EDVLLYAMFPEIGRQFLEQRKNN---QLIPEPLLTQ--SSAPDN 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789  86 AASGVYTVEVEGKAFVVKVS----------------DGGDVSQLSAAPVAAAPAAAPAPAGAGTP--VTAPLAGTIWKVL 147
Cdd:PRK14042  461 SVMSEFDIILHGESYHVKVAgygmiehgqqscflwvDGVPEEVVVQHSELHDKIERSSVNNKIGPgdITVAIPGSIIAIH 540

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2103685789 148 AAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK14042  541 VSAGDEVKAGQAVLVIEAMKMETEIKAPANGVV 573
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 133-180 3.53e-09

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 51.06  E-value: 3.53e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2103685789 133 TPVTAPLAGT-----IWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:pfam00364   1 TEIKSPMIGEsvregVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVV 53
PRK12331 PRK12331
oxaloacetate decarboxylase subunit alpha;
3-64 4.12e-09

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 183446 [Multi-domain]  Cd Length: 448  Bit Score: 54.71  E-value: 4.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2103685789   3 ADPVTCRPADLLKPELAQLEADVRRQAQEKgitlaenaiDDVLTVALFPQPGLKFLENRHNP 64
Cdd:PRK12331  395 EEVITCRPADLIEPQLEKLREEIAEYAESE---------EDVLSYALFPQQAKDFLGRREDP 447
PRK14041 PRK14041
pyruvate carboxylase subunit B;
5-104 1.29e-08

pyruvate carboxylase subunit B;


Pssm-ID: 237593 [Multi-domain]  Cd Length: 467  Bit Score: 53.25  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103685789   5 PVTCRPADLLKPELaqleadvRRQAQEKGItLAENAiDDVLTVALFPQPGLKFLENRHNpaafepvpqveaaqplakaEK 84
Cdd:PRK14041  393 PIDCRPADLLEPEL-------EKARKELGI-LAETD-EDLLIYVILGEVGKKFLKKKYE-------------------EK 444

                          90       100
                  ....*....|....*....|
gi 2103685789  85 PAASGVYTVEVEGKAFVVKV 104
Cdd:PRK14041  445 IGVDFNLLEELSGFTDDMPV 464
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 140-180 2.20e-05

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 40.89  E-value: 2.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2103685789 140 AGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:cd06663    13 DGTVVKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTV 53
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 133-163 1.52e-04

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 38.17  E-value: 1.52e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2103685789 133 TPVTAPLAGTIWKVLAAEGQTVAEGEVLLIL 163
Cdd:cd06850    37 NEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
135-180 1.79e-04

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 38.46  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2103685789 135 VTAPLAGTIWK-------VLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK07051    6 IVSPLPGTFYRrpspdapPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRV 58
PRK05889 PRK05889
biotin/lipoyl-binding carrier protein;
135-180 3.51e-04

biotin/lipoyl-binding carrier protein;


Pssm-ID: 180306 [Multi-domain]  Cd Length: 71  Bit Score: 37.48  E-value: 3.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2103685789 135 VTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:PRK05889    5 VRAEIVASVLEVVVNEGDQIGKGDTLVLLESMKMEIPVLAEVAGTV 50
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 133-177 5.59e-04

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 39.54  E-value: 5.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2103685789 133 TPVTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQA 177
Cdd:COG0845    24 VEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQA 68
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 141-180 3.12e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 35.04  E-value: 3.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2103685789 141 GTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:COG0508    17 GTIVEWLVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVL 56
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 133-164 3.15e-03

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 37.43  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2103685789  133 TPVTAPLAGTIWKVLAAEGQTVAEGEVLLILE 164
Cdd:PRK12999  1114 TTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 141-180 3.34e-03

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 34.69  E-value: 3.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2103685789 141 GTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQAGTV 180
Cdd:cd06849    15 GTIVEWLVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVL 54
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
134-177 3.72e-03

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 33.96  E-value: 3.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2103685789 134 PVTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQA 177
Cdd:pfam13533   4 KIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEA 47
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
133-177 5.66e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 36.56  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2103685789 133 TPVTAPLAGTIWKVLAAEGQTVAEGEVLLILEAMKMETEIRAAQA 177
Cdd:COG1566    46 VTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEA 90
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 133-164 7.60e-03

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 34.87  E-value: 7.60e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2103685789 133 TPVTAPLAGTIWKVLAAEGQTVAEGEVLLILE 164
Cdd:COG0511   105 NEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 134-164 9.02e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 33.61  E-value: 9.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2103685789 134 PVTAPLAGTIWKVLAAEGQTVAEGEVLLILE 164
Cdd:PRK08225   40 PIVAEEAGTVKKINVQEGDFVNEGDVLLEIE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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