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Conserved domains on  [gi|210096|gb|AAC15907|]
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transforming protein [Avian myeloblastosis virus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 80-125 1.21e-20

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


:

Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.23  E-value: 1.21e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 210096      80 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 125
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Cmyb_C super family cl07814
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 210-253 1.41e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


The actual alignment was detected with superfamily member pfam09316:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 72.01  E-value: 1.41e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 210096     210 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 253
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
 
Name Accession Description Interval E-value
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 80-125 1.21e-20

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.23  E-value: 1.21e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 210096      80 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 125
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 210-253 1.41e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 72.01  E-value: 1.41e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 210096     210 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 253
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
 
Name Accession Description Interval E-value
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 80-125 1.21e-20

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.23  E-value: 1.21e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 210096      80 NIINVPQPAAAAIQRHYTDEDPEKEKRIKELELLLMSTENELKGQQ 125
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 210-253 1.41e-15

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 72.01  E-value: 1.41e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 210096     210 QLIDSFLNTSSNHENLNLDNPALTSTPVCGHKMSVTTPFHKDQT 253
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQT 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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