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Conserved domains on  [gi|2100222889|gb|UBK22944|]
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tyrosinase, partial [Arthroleptis variabilis]

Protein Classification

tyrosinase family protein( domain architecture ID 320631)

tyrosinase family protein such as tyrosinase, a metal-containing oxidase that catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine; may be partial

Gene Ontology:  GO:0046872|GO:0016491
PubMed:  29473882|11412044

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tyrosinase super family cl02830
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 111-164 9.21e-08

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


The actual alignment was detected with superfamily member pfam00264:

Pssm-ID: 470683  Cd Length: 209  Bit Score: 49.39  E-value: 9.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2100222889 111 NVYDLFVWLHYYASRDAFleggavwqnidfAHEAPGFLPWHRYFLLLWEREIQK 164
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALRE 43
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-47 9.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 35.41  E-value: 9.87e-04
                          10        20
                  ....*....|....*....|
gi 2100222889  28 TCQCRGNFMGYNCGECKFGY 47
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGY 38
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 111-164 9.21e-08

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 49.39  E-value: 9.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2100222889 111 NVYDLFVWLHYYASRDAFleggavwqnidfAHEAPGFLPWHRYFLLLWEREIQK 164
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALRE 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 28-47 9.87e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 9.87e-04
                          10        20
                  ....*....|....*....|
gi 2100222889  28 TCQCRGNFMGYNCGECKFGY 47
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 29-50 4.45e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 33.87  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|..
gi 2100222889  29 CQCRGNFMGYNCGECKFGYAGP 50
Cdd:cd00055    21 CECKPNTTGRRCDRCAPGYYGL 42
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 111-164 9.21e-08

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 49.39  E-value: 9.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2100222889 111 NVYDLFVWLHYYASRDAFleggavwqnidfAHEAPGFLPWHRYFLLLWEREIQK 164
Cdd:pfam00264   2 SSYDDFAAIHGIPFTPWP------------IHGNGLFLPWHRYYLLLFEQALRE 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 28-47 9.87e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 9.87e-04
                          10        20
                  ....*....|....*....|
gi 2100222889  28 TCQCRGNFMGYNCGECKFGY 47
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 29-50 4.45e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 33.87  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|..
gi 2100222889  29 CQCRGNFMGYNCGECKFGYAGP 50
Cdd:cd00055    21 CECKPNTTGRRCDRCAPGYYGL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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