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Conserved domains on  [gi|209862823|ref|NP_859058|]
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CHD1 helical C-terminal domain containing protein 1 [Homo sapiens]

Protein Classification

DUF4208 domain-containing protein( domain architecture ID 10621412)

DUF4208 domain-containing protein similar to C-terminal domain of Homo sapiens chromodomain-helicase-dna-binding Protein 1 (CHD1), an ATP-dependent chromatin remodelling protein that has an ability to assemble and organize nucleosomes both in vitro and in vivo

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4208 pfam13907
Domain of unknown function (DUF4208); This domain is found at the C-terminus of ...
 50-132 3.43e-17

Domain of unknown function (DUF4208); This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins. The exact function of the domain is undetermined.


:

Pssm-ID: 464035  Cd Length: 93  Bit Score: 73.83  E-value: 3.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862823   50 KTCKEYLRPLKKFLRKLH-LPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQaWEIKHWRKMLWRFISLFSELE--AKQ 126
Cdd:pfam13907   9 EECKELMRPVKKSLKRLKkGTKGLSRKERAKILKKELLKIGDFIDSLLEETKK-EKKEKLRKHLWSFVSKFWPNKvsGKK 87


                  ....*.
gi 209862823  127 LRRLYK 132
Cdd:pfam13907  88 LKEMYK 93
 
Name Accession Description Interval E-value
DUF4208 pfam13907
Domain of unknown function (DUF4208); This domain is found at the C-terminus of ...
 50-132 3.43e-17

Domain of unknown function (DUF4208); This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins. The exact function of the domain is undetermined.


Pssm-ID: 464035  Cd Length: 93  Bit Score: 73.83  E-value: 3.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862823   50 KTCKEYLRPLKKFLRKLH-LPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQaWEIKHWRKMLWRFISLFSELE--AKQ 126
Cdd:pfam13907   9 EECKELMRPVKKSLKRLKkGTKGLSRKERAKILKKELLKIGDFIDSLLEETKK-EKKEKLRKHLWSFVSKFWPNKvsGKK 87


                  ....*.
gi 209862823  127 LRRLYK 132
Cdd:pfam13907  88 LKEMYK 93
TRAX cd14820
Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its ...
 37-88 8.75e-03

Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its binding partner protein Translin and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). TRAX complexed with Translin is possibly involved in dendritic RNA processing and in DNA double-strand break repair as an interacting partner with C1D, an activator of the DNA-dependent protein kinase involved in the repair of DNA-double strand breaks. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271350 [Multi-domain]  Cd Length: 182  Bit Score: 36.00  E-value: 8.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 209862823  37 LMRHA-----KGlDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVL 88
Cdd:cd14820  121 LMRYAidslrKG-DLEEAEKYLEFMEEIYEGLMSFDYPDALELRKKLDVDRQSLLKE 176
 
Name Accession Description Interval E-value
DUF4208 pfam13907
Domain of unknown function (DUF4208); This domain is found at the C-terminus of ...
 50-132 3.43e-17

Domain of unknown function (DUF4208); This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins. The exact function of the domain is undetermined.


Pssm-ID: 464035  Cd Length: 93  Bit Score: 73.83  E-value: 3.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209862823   50 KTCKEYLRPLKKFLRKLH-LPRDLPQKKKLKYMKQSLVVLGDHINTFLQHYCQaWEIKHWRKMLWRFISLFSELE--AKQ 126
Cdd:pfam13907   9 EECKELMRPVKKSLKRLKkGTKGLSRKERAKILKKELLKIGDFIDSLLEETKK-EKKEKLRKHLWSFVSKFWPNKvsGKK 87


                  ....*.
gi 209862823  127 LRRLYK 132
Cdd:pfam13907  88 LKEMYK 93
TRAX cd14820
Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its ...
 37-88 8.75e-03

Translin-associated factor-X (TRAX); TRAX (translin-associated factor-X) is a paralog of its binding partner protein Translin and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC). TRAX complexed with Translin is possibly involved in dendritic RNA processing and in DNA double-strand break repair as an interacting partner with C1D, an activator of the DNA-dependent protein kinase involved in the repair of DNA-double strand breaks. It has been shown that Trax subunit, but not Translin, possesses a Glu-Glu-Asp catalytic center with the capacity to digest RNA; this catalytic activity is required for passenger-strand removal and RISC activation in RNAi. In Archaeoglobus fulgidus, Trax-like-subunits assemble into an octameric structure, highly similar to human C3PO; its complex with duplex RNA reveals that the octamer entirely encapsulates a single 13-base-pair RNA duplex inside a large inner cavity. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis; however, their precise role in some of the processes remains unclear.


Pssm-ID: 271350 [Multi-domain]  Cd Length: 182  Bit Score: 36.00  E-value: 8.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 209862823  37 LMRHA-----KGlDQDTFKTCKEYLRPLKKFLRKLHLPRDLPQKKKLKYMKQSLVVL 88
Cdd:cd14820  121 LMRYAidslrKG-DLEEAEKYLEFMEEIYEGLMSFDYPDALELRKKLDVDRQSLLKE 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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