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Conserved domains on  [gi|2098556083|ref|XP_043660448|]
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homeotic protein female sterile isoform X2 [Drosophila teissieri]

Protein Classification

Bromo_Brdt_I_like and Bromo_Brdt_II_like domain-containing protein( domain architecture ID 10860762)

protein containing domains Bromo_Brdt_I_like, Bromo_Brdt_II_like, BET, and BRD4_CDT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 34-140 8.03e-75

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99929  Cd Length: 107  Bit Score: 243.48  E-value: 8.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   34 RNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCY 113
Cdd:cd05497      1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  114 VYNKPGEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05497     81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 480-580 4.47e-67

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99930  Cd Length: 102  Bit Score: 221.38  E-value: 4.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05498      2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                           90       100
                   ....*....|....*....|.
gi 2098556083  560 PPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05498     82 PPDHPVHAMARKLQDVFEDRW 102
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 948-1012 2.43e-27

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


:

Pssm-ID: 435704  Cd Length: 64  Bit Score: 106.43  E-value: 2.43e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2098556083  948 PMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRdSNPDEIEIDFETLKPSTLRELESYVAS 1012
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFVKK 64
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 2010-2030 5.89e-08

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


:

Pssm-ID: 465349  Cd Length: 44  Bit Score: 50.47  E-value: 5.89e-08
                           10        20
                   ....*....|....*....|.
gi 2098556083 2010 LAGQIDMNMQSDLMAAFEETL 2030
Cdd:pfam17105   23 MAGTIDMNLQSDIMASFEENL 43
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 34-140 8.03e-75

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 243.48  E-value: 8.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   34 RNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCY 113
Cdd:cd05497      1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  114 VYNKPGEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05497     81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 480-580 4.47e-67

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 221.38  E-value: 4.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05498      2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                           90       100
                   ....*....|....*....|.
gi 2098556083  560 PPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05498     82 PPDHPVHAMARKLQDVFEDRW 102
BROMO smart00297
bromo domain;
34-138 4.87e-38

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 138.57  E-value: 4.87e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083    34 RNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCY 113
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*
gi 2098556083   114 VYNKPGEDVVVMAQTLEKVFLQKIE 138
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLR 105
BROMO smart00297
bromo domain;
480-583 1.17e-37

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 137.41  E-value: 1.17e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   480 LKSCNEILKELFSKKHSG-YAWPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKY 558
Cdd:smart00297    5 QKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 2098556083   559 NPPDHDVVAMGRKLQDVFEMRYANI 583
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 948-1012 2.43e-27

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 106.43  E-value: 2.43e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2098556083  948 PMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRdSNPDEIEIDFETLKPSTLRELESYVAS 1012
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFVKK 64
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 56-149 2.58e-22

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 101.04  E-value: 2.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   56 SWPFqqPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQ 135
Cdd:COG5076    166 SSIF--LGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLK 243

                           90
                   ....*....|....
gi 2098556083  136 KIESMPKEELELEP 149
Cdd:COG5076    244 LIEEIPEEMLELSI 257
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 43-128 7.92e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.22  E-value: 7.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   43 IKTVMKVIWKHHFSWPFQQPVDAKklNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDV 122
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                   ....*.
gi 2098556083  123 VVMAQT 128
Cdd:pfam00439   79 YKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 483-571 9.38e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 88.14  E-value: 9.38e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  483 CNEILKELfsKKHSGYAWpFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPD 562
Cdd:pfam00439    1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                   ....*....
gi 2098556083  563 HDVVAMGRK 571
Cdd:pfam00439   76 SVIYKAAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 487-592 6.34e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 94.10  E-value: 6.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  487 LKELFSKKHSGYAWPFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVV 566
Cdd:COG5076    154 KKQLFLRDGRFLSSIFLGLPSKREYP--DYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVY 231

                           90       100
                   ....*....|....*....|....*.
gi 2098556083  567 AMGRKLQDVFEMRYANIPDEPVANAA 592
Cdd:COG5076    232 VDAKELEKYFLKLIEEIPEEMLELSI 257
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 2010-2030 5.89e-08

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 50.47  E-value: 5.89e-08
                           10        20
                   ....*....|....*....|.
gi 2098556083 2010 LAGQIDMNMQSDLMAAFEETL 2030
Cdd:pfam17105   23 MAGTIDMNLQSDIMASFEENL 43
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 34-140 8.03e-75

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 243.48  E-value: 8.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   34 RNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCY 113
Cdd:cd05497      1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  114 VYNKPGEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05497     81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 480-580 4.47e-67

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 221.38  E-value: 4.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05498      2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                           90       100
                   ....*....|....*....|.
gi 2098556083  560 PPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05498     82 PPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 480-578 9.43e-44

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 154.75  E-value: 9.43e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05499      2 LKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                           90
                   ....*....|....*....
gi 2098556083  560 PPDHDVVAMGRKLQDVFEM 578
Cdd:cd05499     82 PEGTDVYMMGHQLEEVFND 100
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 479-580 1.93e-42

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 150.56  E-value: 1.93e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  479 ALKSCNEILKELFSKKHSgyaWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKY 558
Cdd:cd05506      1 VMKQCGTLLRKLMKHKWG---WVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRY 77

                           90       100
                   ....*....|....*....|..
gi 2098556083  559 NPPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05506     78 NPPGNDVHTMAKELLKIFETRW 99
BROMO smart00297
bromo domain;
34-138 4.87e-38

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 138.57  E-value: 4.87e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083    34 RNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCY 113
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*
gi 2098556083   114 VYNKPGEDVVVMAQTLEKVFLQKIE 138
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLR 105
BROMO smart00297
bromo domain;
480-583 1.17e-37

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 137.41  E-value: 1.17e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   480 LKSCNEILKELFSKKHSG-YAWPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKY 558
Cdd:smart00297    5 QKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 2098556083   559 NPPDHDVVAMGRKLQDVFEMRYANI 583
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 55-136 3.68e-35

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 130.09  E-value: 3.68e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   55 FSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFL 134
Cdd:cd05498     20 YAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDVFE 99


                   ..
gi 2098556083  135 QK 136
Cdd:cd05498    100 DR 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 481-580 3.92e-33

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 124.02  E-value: 3.92e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  481 KSCNEILKELFSKKHSgYAWPFYKPVDAEmlGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNP 560
Cdd:cd04369      3 KKLRSLLDALKKLKRD-LSEPFLEPVDPK--EAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNG 79

                           90       100
                   ....*....|....*....|
gi 2098556083  561 PDHDVVAMGRKLQDVFEMRY 580
Cdd:cd04369     80 PGSPIYKDAKKLEKLFEKLL 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 38-140 6.29e-33

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 123.43  E-value: 6.29e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   38 QLQYLIKTVMKVIWKHHFSWPFQQPVDAKklNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNK 117
Cdd:cd05509      1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKE--EAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNG 78

                           90       100
                   ....*....|....*....|...
gi 2098556083  118 PGEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05509     79 PDTEYYKCANKLEKFFWKKLKEL 101
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 484-576 2.23e-32

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 122.14  E-value: 2.23e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  484 NEILKELFSKKHsgyAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDH 563
Cdd:cd05497     11 KVVLKALWKHKF---AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGD 87

                           90
                   ....*....|...
gi 2098556083  564 DVVAMGRKLQDVF 576
Cdd:cd05497     88 DVVLMAQTLEKLF 100
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 39-137 8.10e-32

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 120.55  E-value: 8.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   39 LQYLIKTVMKVIWKHH--FSWPFQQPVDAKklNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYN 116
Cdd:cd04369      1 LKKKLRSLLDALKKLKrdLSEPFLEPVDPK--EAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYN 78

                           90       100
                   ....*....|....*....|.
gi 2098556083  117 KPGEDVVVMAQTLEKVFLQKI 137
Cdd:cd04369     79 GPGSPIYKDAKKLEKLFEKLL 99
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 45-133 3.35e-31

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 118.59  E-value: 3.35e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   45 TVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVV 124
Cdd:cd05506      7 TLLRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHT 86


                   ....*....
gi 2098556083  125 MAQTLEKVF 133
Cdd:cd05506     87 MAKELLKIF 95
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 482-577 3.21e-30

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 115.73  E-value: 3.21e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  482 SCNEILKELfsKKHSgYAWPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPP 561
Cdd:cd05509      5 QLKKVLDSL--KNHK-SAWPFLEPVDKEEA--PDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGP 79

                           90
                   ....*....|....*.
gi 2098556083  562 DHDVVAMGRKLQDVFE 577
Cdd:cd05509     80 DTEYYKCANKLEKFFW 95
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 52-133 8.79e-29

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 111.99  E-value: 8.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   52 KHH-FSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLE 130
Cdd:cd05499     16 KHSaYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLE 95


                   ...
gi 2098556083  131 KVF 133
Cdd:cd05499     96 EVF 98
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 948-1012 2.43e-27

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 106.43  E-value: 2.43e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2098556083  948 PMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRdSNPDEIEIDFETLKPSTLRELESYVAS 1012
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFVKK 64
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 38-137 1.28e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 105.86  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   38 QLQYLIKTVmKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNK 117
Cdd:cd05500      5 QHKFLLSSI-RSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNG 83

                           90       100
                   ....*....|....*....|
gi 2098556083  118 PGEDVVVMAQTLEKVFLQKI 137
Cdd:cd05500     84 PEHPVSQMGKRLQAAFEKHL 103
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 473-585 1.72e-26

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 105.60  E-value: 1.72e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  473 KEKLSDAL-KSCNEILKELfsKKHSGYAWPFYKPV---DAemlglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADV 548
Cdd:cd05510      1 ERIGQEEFyESLDKVLNEL--KTYTEHSTPFLTKVskrEA-----PDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDL 73

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2098556083  549 RLIFTNCYKYNP-PDHDVVAMGRKLQDVFEMRYANIPD 585
Cdd:cd05510     74 NLIWKNCLLYNSdPSHPLRRHANFMKKKAEHLLKLIPD 111
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 499-577 2.44e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 104.70  E-value: 2.44e-26
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2098556083  499 AWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFE 577
Cdd:cd05500     22 ARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQAAFE 100
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 480-580 2.60e-25

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 102.47  E-value: 2.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELfsKKHSGyAWPFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05504     14 LSALEQLLVEI--VKHKD-SWPFLRPVSKIEVP--DYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYN 88

                           90       100
                   ....*....|....*....|.
gi 2098556083  560 PPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05504     89 PEHTSVYKAGTRLQRFFIKRC 109
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 480-585 3.18e-25

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 101.98  E-value: 3.18e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSGyawPFYKPVDAEMlglHDYHDIIKKPMDLGTVKRKMDNRE---YKSAPEFAADVRLIFTNCY 556
Cdd:cd05502      6 QRKCERLLLELYCHELSL---PFHEPVSPSV---PNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCY 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 2098556083  557 KYNPPDHDVVAMGRKLQDVFEMRYANI-PD 585
Cdd:cd05502     80 KFNEEDSEVAQAGKELELFFEEQLKEIlPD 109
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 486-577 1.24e-24

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 100.21  E-value: 1.24e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  486 ILKELFskKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDV 565
Cdd:cd05495     11 TLEKLY--KQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRV 88

                           90
                   ....*....|..
gi 2098556083  566 VAMGRKLQDVFE 577
Cdd:cd05495     89 YKYCTKLAEVFE 100
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 39-140 2.28e-24

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 99.44  E-value: 2.28e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   39 LQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKP 118
Cdd:cd05495      5 RQALMPTLEKLYKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRK 84

                           90       100
                   ....*....|....*....|..
gi 2098556083  119 GEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05495     85 TSRVYKYCTKLAEVFEQEIDPV 106
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 56-149 2.58e-22

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 101.04  E-value: 2.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   56 SWPFqqPVDAKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQ 135
Cdd:COG5076    166 SSIF--LGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLK 243

                           90
                   ....*....|....
gi 2098556083  136 KIESMPKEELELEP 149
Cdd:COG5076    244 LIEEIPEEMLELSI 257
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 43-128 7.92e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.22  E-value: 7.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   43 IKTVMKVIWKHHFSWPFQQPVDAKklNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDV 122
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                   ....*.
gi 2098556083  123 VVMAQT 128
Cdd:pfam00439   79 YKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 483-571 9.38e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 88.14  E-value: 9.38e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  483 CNEILKELfsKKHSGYAWpFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPD 562
Cdd:pfam00439    1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                   ....*....
gi 2098556083  563 HDVVAMGRK 571
Cdd:pfam00439   76 SVIYKAAEK 84
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 483-580 1.85e-20

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 87.82  E-value: 1.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  483 CNEILKELfsKKHSGyAWPFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPD 562
Cdd:cd05503      5 CETILDEM--EAHED-AWPFLEPVNTKLVP--GYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDD 79

                           90
                   ....*....|....*...
gi 2098556083  563 HDVVAMGRKLQDVFEMRY 580
Cdd:cd05503     80 SEVGRAGHNMRKFFEKRW 97
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 66-137 4.70e-20

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 87.01  E-value: 4.70e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2098556083   66 KKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKI 137
Cdd:cd05519     32 SKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKKY 103
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 50-143 5.83e-20

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 87.07  E-value: 5.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   50 IWKHHFSWPFQQPVdaKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTL 129
Cdd:cd05504     24 IVKHKDSWPFLRPV--SKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKAGTRL 101

                           90
                   ....*....|....
gi 2098556083  130 EKVFLQKIESMPKE 143
Cdd:cd05504    102 QRFFIKRCRKLGLP 115
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 487-592 6.34e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 94.10  E-value: 6.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  487 LKELFSKKHSGYAWPFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVV 566
Cdd:COG5076    154 KKQLFLRDGRFLSSIFLGLPSKREYP--DYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVY 231

                           90       100
                   ....*....|....*....|....*.
gi 2098556083  567 AMGRKLQDVFEMRYANIPDEPVANAA 592
Cdd:COG5076    232 VDAKELEKYFLKLIEEIPEEMLELSI 257
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 42-136 1.51e-19

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 85.12  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   42 LIKTVMKVIWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGED 121
Cdd:cd05503      4 LCETILDEMEAHEDAWPFLEPVNTKLV--PGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSE 81

                           90
                   ....*....|....*
gi 2098556083  122 VVVMAQTLEKVFLQK 136
Cdd:cd05503     82 VGRAGHNMRKFFEKR 96
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 486-578 3.56e-19

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 84.62  E-value: 3.56e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  486 ILKELFSK-KHSGYAWPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHd 564
Cdd:cd05511      4 ILDEIVNElKNLPDSWPFHTPVNKKKV--PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS- 80

                           90
                   ....*....|....
gi 2098556083  565 vvAMGRKLQDVFEM 578
Cdd:cd05511     81 --VYTKKAKEMLEL 92
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 480-576 6.94e-19

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 83.35  E-value: 6.94e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  480 LKSCNEILKELFSKKHSgyaWPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05505      2 LQKCEEILSKILKYRFS---WPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYY 76

                           90
                   ....*....|....*..
gi 2098556083  560 PPDHDVVAMGRKLQDVF 576
Cdd:cd05505     77 ENGSYVLSCMRKTEQCC 93
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 56-141 9.45e-18

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 80.56  E-value: 9.45e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   56 SWPFQQPVdaKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNK-PGEDVVVMAQTLEKVFL 134
Cdd:cd05510     26 STPFLTKV--SKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdPSHPLRRHANFMKKKAE 103


                   ....*..
gi 2098556083  135 QKIESMP 141
Cdd:cd05510    104 HLLKLIP 110
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 477-577 1.63e-17

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 80.19  E-value: 1.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  477 SDALKSCNEILKELFSKKHSGyawPFYKPVDaeMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCY 556
Cdd:cd05496      4 SDWKKQCKELVNLMWDCEDSE---PFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSK 78

                           90       100
                   ....*....|....*....|..
gi 2098556083  557 KYNPPDHD-VVAMGRKLQDVFE 577
Cdd:cd05496     79 SYTPNKRSrIYSMTLRLSALFE 100
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 56-148 2.56e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 79.62  E-value: 2.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   56 SWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQ 135
Cdd:cd05511     18 SWPFHTPVNKKKV--PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEMLELAEE 95

                           90
                   ....*....|...
gi 2098556083  136 KIESMPKEELELE 148
Cdd:cd05511     96 LLAEREEKLTQLE 108
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 53-138 3.47e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 78.87  E-value: 3.47e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   53 HHFSWPFQQPVdakKLNLPDYHKIIKQPMDMGTIKKRLE---NNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTL 129
Cdd:cd05502     19 HELSLPFHEPV---SPSVPNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKEL 95


                   ....*....
gi 2098556083  130 EKVFLQKIE 138
Cdd:cd05502     96 ELFFEEQLK 104
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 52-136 4.39e-17

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 78.50  E-value: 4.39e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   52 KHHFSWPFQQ-PvdaKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLE 130
Cdd:cd05515     20 GRRLSLIFMRlP---SKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQ 96


                   ....*.
gi 2098556083  131 KVFLQK 136
Cdd:cd05515     97 KVLLET 102
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 501-575 3.75e-15

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 73.16  E-value: 3.75e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2098556083  501 PFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHD----VVAMGRKLQDV 575
Cdd:cd05528     23 AFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPadklIRSRACELRDE 99
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 498-574 7.97e-15

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 72.01  E-value: 7.97e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2098556083  498 YAWPFYKPVDAEmlGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQD 574
Cdd:cd05507     20 YASVFLKPVTED--IAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVEMQR 94
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 41-140 1.84e-14

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 71.98  E-value: 1.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   41 YLIKTVMKVIWKHHFSW--PFQQPVDaKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKP 118
Cdd:cd05529     28 RLISGLDKLLLSLQLEIaeYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEP 106

                           90       100
                   ....*....|....*....|..
gi 2098556083  119 GEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05529    107 NSEIAKKAKRLSDWLLRILSSL 128
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 71-136 5.87e-14

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 69.78  E-value: 5.87e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2098556083   71 PDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQK 136
Cdd:cd05518     37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEK 102
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 38-133 1.53e-13

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 68.61  E-value: 1.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   38 QLQYLIKTVMKVIWKHH------FSWPFQQpVDAKKlNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNN 111
Cdd:cd05516      1 ELTKKMNKIVDVVIKYKdsdgrqLAEVFIQ-LPSRK-ELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQN 78

                           90       100
                   ....*....|....*....|..
gi 2098556083  112 CYVYNKPGEDVVVMAQTLEKVF 133
Cdd:cd05516     79 AQTFNLEGSLIYEDSIVLQSVF 100
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 59-116 1.55e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 68.19  E-value: 1.55e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2098556083   59 FQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYN 116
Cdd:cd05512     22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYN 77
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 50-123 2.17e-13

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 67.95  E-value: 2.17e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2098556083   50 IWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVV 123
Cdd:cd05505     12 ILKYRFSWPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVL 83
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 44-141 4.60e-13

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 67.00  E-value: 4.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   44 KTVMKV---IWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGE 120
Cdd:cd05507      6 KAILLVyrtLASHRYASVFLKPVTEDIA--PGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDH 83

                           90       100
                   ....*....|....*....|.
gi 2098556083  121 DVVVMAQTLEKVFLQKIESMP 141
Cdd:cd05507     84 DVYLMAVEMQREVMSQIQQLL 104
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 502-562 8.12e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 66.27  E-value: 8.12e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2098556083  502 FYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPD 562
Cdd:cd05512     22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 39-119 1.36e-12

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 65.51  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   39 LQYLIKTVMKVIWKHHFSWPFQQPVdakklnLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKP 118
Cdd:cd05513      6 LEQLIRQLQRKDPHGFFAFPVTDFI------APGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKP 79


                   .
gi 2098556083  119 G 119
Cdd:cd05513     80 D 80
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 44-137 4.71e-12

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 64.79  E-value: 4.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   44 KTVMKVIWKHHFSWPFQQPVDakKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVY--NKPGEd 121
Cdd:cd05496     11 KELVNLMWDCEDSEPFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYtpNKRSR- 87

                           90
                   ....*....|....*.
gi 2098556083  122 VVVMAQTLEKVFLQKI 137
Cdd:cd05496     88 IYSMTLRLSALFEEHI 103
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 515-565 6.06e-12

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 63.86  E-value: 6.06e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDV 565
Cdd:cd05515     38 DYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQI 88
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 481-562 2.51e-11

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 62.04  E-value: 2.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  481 KSCNEILKELFSKKHSGYawpFYKPVDAEMLGlhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNP 560
Cdd:cd05513      4 KALEQLIRQLQRKDPHGF---FAFPVTDFIAP--GYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNK 78


                   ..
gi 2098556083  561 PD 562
Cdd:cd05513     79 PD 80
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 43-133 4.76e-11

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 61.49  E-value: 4.76e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   43 IKTVMKVIWK------HHFSWPFQQPVDakKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYN 116
Cdd:cd05522      6 IKNILKGLRKerdengRLLTLHFEKLPD--KAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYN 83

                           90
                   ....*....|....*..
gi 2098556083  117 KPGEDVVVMAQTLEKVF 133
Cdd:cd05522     84 ENDSQEYKDAVLLEKEA 100
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 38-140 7.79e-11

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 60.83  E-value: 7.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   38 QLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYN- 116
Cdd:cd05528      3 ELRLFLRDVLKRLASDKRFNAFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNp 80

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  117 ---KPGEDVVVMAQTLEKVFLQKIESM 140
Cdd:cd05528     81 drdPADKLIRSRACELRDEVHAMIEAE 107
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 473-576 5.47e-10

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 59.27  E-value: 5.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  473 KEKLSDALKSCNEILKELF---SKKHSGYAWPFYKPVDaEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVR 549
Cdd:cd05529     16 WEQPHIRDEERERLISGLDkllLSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVR 94

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  550 LIFTNCYKYNPPDHDVVAMGRKLQDVF 576
Cdd:cd05529     95 LILSNAETFNEPNSEIAKKAKRLSDWL 121
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 515-575 7.14e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 58.12  E-value: 7.14e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDV 575
Cdd:cd05520     38 DYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKL 98
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 515-583 8.67e-10

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 57.82  E-value: 8.67e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDhDVVAMGRKLQDVFEMRYANI 583
Cdd:cd05501     32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDD-DFGQVGITLEKKFEKNFKEV 99
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 71-136 3.63e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 55.81  E-value: 3.63e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2098556083   71 PDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQK 136
Cdd:cd05520     37 PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAK 102
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 67-137 4.09e-09

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 55.79  E-value: 4.09e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2098556083   67 KLNLPDYHKIIKQPMDMGTIKKRLENnyYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQKI 137
Cdd:cd05521     34 RKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYINDVI 102
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 515-580 7.74e-09

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 55.04  E-value: 7.74e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRY 580
Cdd:cd05519     38 DYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKKY 103
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 36-132 9.06e-09

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 54.70  E-value: 9.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   36 TNQLQYLIKTVMKVIwKHHFSWPFQQPVDAKKLnlPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVY 115
Cdd:cd05508      1 VDQLSKLLKFALERM-KQPGAEPFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIY 77

                           90
                   ....*....|....*..
gi 2098556083  116 NKPGEDVVVMAQTLEKV 132
Cdd:cd05508     78 NGGDHKLTQAAKAIVKI 94
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 67-136 4.64e-08

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 52.83  E-value: 4.64e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   67 KLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQK 136
Cdd:cd05517     33 KVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIFTAK 102
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 2010-2030 5.89e-08

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 50.47  E-value: 5.89e-08
                           10        20
                   ....*....|....*....|.
gi 2098556083 2010 LAGQIDMNMQSDLMAAFEETL 2030
Cdd:pfam17105   23 MAGTIDMNLQSDIMASFEENL 43
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 483-537 7.13e-08

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 52.45  E-value: 7.13e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2098556083  483 CNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTvkrKMDNRE 537
Cdd:cd05494      5 LERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGT---KVNNIV 56
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 474-565 1.60e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 51.23  E-value: 1.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  474 EKLSDALKSCNEILKELFSKkhsgyawPFYKPVDAEMLglHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFT 553
Cdd:cd05508      2 DQLSKLLKFALERMKQPGAE-------PFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILH 72

                           90
                   ....*....|..
gi 2098556083  554 NCYKYNPPDHDV 565
Cdd:cd05508     73 NAIIYNGGDHKL 84
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 515-577 1.78e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 51.57  E-value: 1.78e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFE 577
Cdd:cd05524     40 EYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFL 102
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 515-583 4.71e-07

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 50.01  E-value: 4.71e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNreYKSAPEFAADVRLIFTNCYKYNPPDHDVVamgrklqdvfemRYANI 583
Cdd:cd05521     39 DYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIY------------KYALI 93
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 515-562 4.93e-07

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 49.93  E-value: 4.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPD 562
Cdd:cd05522     39 EYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNEND 86
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 66-135 1.18e-06

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 48.93  E-value: 1.18e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   66 KKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQ 135
Cdd:cd05525     34 SKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 481-583 1.26e-06

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 48.96  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  481 KSCNEILKELFS-KKHSGY--AWPFYK-PVDAEmlgLHDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCY 556
Cdd:cd05516      4 KKMNKIVDVVIKyKDSDGRqlAEVFIQlPSRKE---LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQ 80

                           90       100
                   ....*....|....*....|....*..
gi 2098556083  557 KYNPPDHDVVAMGRKLQDVFEMRYANI 583
Cdd:cd05516     81 TFNLEGSLIYEDSIVLQSVFKSARQKI 107
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 489-559 2.60e-06

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 47.83  E-value: 2.60e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2098556083  489 ELFSKKHSGYAWPfykpvdaemlglhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYN 559
Cdd:cd05518     25 DLFMEKPSKKDYP-------------DYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYN 82
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 72-133 3.54e-06

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 47.42  E-value: 3.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2098556083   72 DYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKpGEDVVVMAQTLEKVF 133
Cdd:cd05501     32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYK-DDDFGQVGITLEKKF 92
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 66-144 4.18e-06

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 47.71  E-value: 4.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083   66 KKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQ-KIESMPKEE 144
Cdd:cd05524     34 KRRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSaRNEVLSGGE 113
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 484-580 7.69e-06

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 46.66  E-value: 7.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2098556083  484 NEILKELFSKKHSGYAWPfykpvdaemlglhDYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDH 563
Cdd:cd05517     20 GRLISELFQKLPSKVLYP-------------DYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGS 86

                           90
                   ....*....|....*..
gi 2098556083  564 DVVAMGRKLQDVFEMRY 580
Cdd:cd05517     87 QVYKDANAIKKIFTAKK 103
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 46-91 1.65e-05

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 45.90  E-value: 1.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2098556083   46 VMKVIWKHHFSWPFQQPVDAKKLNLPDYHKIIKQPMDMGTIKKRLE 91
Cdd:cd05494     11 ELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIV 56
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 57-133 1.55e-04

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 46.34  E-value: 1.55e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2098556083   57 WPFQQPVdaKKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIHDFNTMFNNCYVYNKPGEDVVVMAQTLEKVF 133
Cdd:COG5076    282 WPFLRPV--SDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFV 356
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 515-577 2.12e-03

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 39.68  E-value: 2.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2098556083  515 DYHDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFE 577
Cdd:cd05525     40 DYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYY 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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