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Conserved domains on  [gi|2097442934|ref|XP_043616524|]
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F-box protein GID2-like [Erigeron canadensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 46-86 8.88e-14

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438922  Cd Length: 44  Bit Score: 62.72  E-value: 8.88e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2097442934  46 DDNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:cd22151     4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
 
Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 46-86 8.88e-14

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 62.72  E-value: 8.88e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2097442934  46 DDNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:cd22151     4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 49-86 4.61e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.39  E-value: 4.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2097442934  49 LLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:pfam12937   8 ILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
47-82 5.38e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 5.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2097442934   47 DNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLW 82
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
 
Name Accession Description Interval E-value
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 46-86 8.88e-14

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 62.72  E-value: 8.88e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2097442934  46 DDNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:cd22151     4 PDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 47-82 2.85e-07

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 2.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2097442934  47 DNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLW 82
Cdd:cd22132     6 DSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLW 41
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 49-86 4.61e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.39  E-value: 4.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2097442934  49 LLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:pfam12937   8 ILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 47-77 1.17e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.81  E-value: 1.17e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2097442934  47 DNLLYEILKHVDARTLGACGCVNKHWNRTSK 77
Cdd:cd09917     5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 44-90 2.36e-04

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 37.62  E-value: 2.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2097442934  44 LQDDNLLYeILKHVDARTLGACGCVNKHWNRTSKDERLWELICTRHW 90
Cdd:cd22084     4 LPSDPLLN-ILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 50-86 2.54e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 37.36  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2097442934  50 LYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:cd22137     8 MLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 47-84 4.48e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.75  E-value: 4.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2097442934  47 DNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLWEL 84
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 47-82 4.90e-04

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 36.58  E-value: 4.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2097442934  47 DNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLW 82
Cdd:cd22149     6 DEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
47-82 5.38e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 5.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2097442934   47 DNLLYEILKHVDARTLGACGCVNKHWNRTSKDERLW 82
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 49-86 9.54e-04

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 35.82  E-value: 9.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2097442934  49 LLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELIC 86
Cdd:cd22134    11 LALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 49-87 3.98e-03

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 34.15  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2097442934  49 LLYEILKHVDARTLGACGCVNKHWNRTSKDERLWELICT 87
Cdd:cd22093     8 ILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLYS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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