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Conserved domains on  [gi|209572589|sp|Q9BXN1|]
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RecName: Full=Asporin; AltName: Full=Periodontal ligament-associated protein 1; Short=PLAP-1; Flags: Precursor

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-324 2.43e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 107 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 184
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 185 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 262
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 209572589 263 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 324
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
74-104 3.38e-08

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.38e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 209572589    74 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 104
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-324 2.43e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 107 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 184
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 185 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 262
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 209572589 263 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 324
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
91-327 8.71e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 8.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  91 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 151
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 152 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSanpldnngiepgafegvtvfhiriaeak 231
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 232 LTSVPKGLPPTLLELHLDYNKISTVElEDFKryKELQRLGLGNNKITDIENgSLAniPRVREIHLENNKLKKIPSGLP-E 310
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLPaA 389

                        250
                 ....*....|....*..
gi 209572589 311 LKYLQIIFlhsNSIARV 327
Cdd:PRK15370 390 LQIMQASR---NNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
105-162 1.17e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 209572589  105 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 162
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-325 8.13e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 8.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  86 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 163
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 164 EIP-LNLPKSLAELRIhenkvkkiqkdtfkgmnalhvlemsanplDNNGIEPG---AFEGVTVFHIRiaeakltsvpkgl 239
Cdd:cd21340   82 VVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------- 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 240 pPTLLELHLDYNKISTveLEDFKRYKELQRLGLGNNKITDIEN--GSLANIPRVREIHLENNKLKKIPsglpelKYLQII 317
Cdd:cd21340  120 -NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP------KYRDKI 190


                 ....*...
gi 209572589 318 FLHSNSIA 325
Cdd:cd21340  191 ILASKSLE 198
LRRNT smart00013
Leucine rich repeat N-terminal domain;
74-104 3.38e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.38e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 209572589    74 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 104
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 74-101 4.34e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.70  E-value: 4.34e-07
                          10        20
                  ....*....|....*....|....*...
gi 209572589   74 MCPFGCQCYSRVVHCSDLGLTSVPTNIP 101
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-324 2.43e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 107 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 184
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 185 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 262
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 209572589 263 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 324
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-304 4.81e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  84 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKENdFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 161
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 162 LSEIPLNLP--KSLAELRIHENKVKKIqkDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGL 239
Cdd:COG4886  217 LTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN-------------------------QLTDLPPLA 269

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209572589 240 P-PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKI 304
Cdd:COG4886  270 NlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
91-327 8.71e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 8.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  91 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 151
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 152 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSanpldnngiepgafegvtvfhiriaeak 231
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 232 LTSVPKGLPPTLLELHLDYNKISTVElEDFKryKELQRLGLGNNKITDIENgSLAniPRVREIHLENNKLKKIPSGLP-E 310
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLPaA 389

                        250
                 ....*....|....*..
gi 209572589 311 LKYLQIIFlhsNSIARV 327
Cdd:PRK15370 390 LQIMQASR---NNLVRL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-296 2.93e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  84 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 161
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 162 LSEIP--LNLPKsLAELRIHENKVKKIqkDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGL 239
Cdd:COG4886  240 LTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 209572589 240 PPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHL 296
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR_8 pfam13855
Leucine rich repeat;
105-162 1.17e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 209572589  105 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 162
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-325 8.13e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 8.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  86 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 163
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 164 EIP-LNLPKSLAELRIhenkvkkiqkdtfkgmnalhvlemsanplDNNGIEPG---AFEGVTVFHIRiaeakltsvpkgl 239
Cdd:cd21340   82 VVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------- 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 240 pPTLLELHLDYNKISTveLEDFKRYKELQRLGLGNNKITDIEN--GSLANIPRVREIHLENNKLKKIPsglpelKYLQII 317
Cdd:cd21340  120 -NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP------KYRDKI 190


                 ....*...
gi 209572589 318 FLHSNSIA 325
Cdd:cd21340  191 ILASKSLE 198
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 246-327 2.26e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 246 LHLDYNKIStvELEDFKRYKELQRLGLGNNKITDIENgsLANIPRVREIHLENNKLKKIPsGLPELKYLQIIFLHSNSIA 325
Cdd:cd21340    7 LYLNDKNIT--KIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIS 81


                 ..
gi 209572589 326 RV 327
Cdd:cd21340   82 VV 83
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 105-321 3.12e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 3.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 105 RMLDLQNNKI-----KEIKENdFKGLTSLYGLILNNNKLTK----IHPKAFLTTKKLRRLYLSHNQLSEiplNLPKSLAE 175
Cdd:COG5238  211 TTLWLKRNPIgdegaEILAEA-LKGNKSLTTLDLSNNQIGDegviALAEALKNNTTVETLYLSGNQIGA---EGAIALAK 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 176 lrihenkvkkiqkdTFKGMNALHVLEMSANPLDnngiEPGAfegvtvfhirIAEAKLTSVPKglppTLLELHLDYNKIST 255
Cdd:COG5238  287 --------------ALQGNTTLTSLDLSVNRIG----DEGA----------IALAEGLQGNK----TLHTLNLAYNGIGA 334

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209572589 256 VE----LEDFKRYKELQRLGLGNNKITDIENGSLA----NIPRVREIHLENNKLKKipSGLPEL-KYLQIIFLHS 321
Cdd:COG5238  335 QGaialAKALQENTTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGK--QGAEALiDALQTNRLHT 407
LRRNT smart00013
Leucine rich repeat N-terminal domain;
74-104 3.38e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.38e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 209572589    74 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 104
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRR_8 pfam13855
Leucine rich repeat;
241-301 3.74e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.74e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209572589  241 PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKL 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 74-101 4.34e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.70  E-value: 4.34e-07
                          10        20
                  ....*....|....*....|....*...
gi 209572589   74 MCPFGCQCYSRVVHCSDLGLTSVPTNIP 101
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-358 5.54e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 150 KKLRRLYLSHNQLSEIP-LNLPKSLAELRIHENKVKKIQK-DTFKGMNALHvlemsanpLDNNGIEpgafegvtvfhiRI 227
Cdd:cd21340    2 KRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIENlEFLTNLTHLY--------LQNNQIE------------KI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 228 AEakLTSVPKglpptLLELHLDYNKISTVE-LEDFKRYKEL----QRLGLGnNKITdIENGSLANI-PRVREIHLENNKL 301
Cdd:cd21340   62 EN--LENLVN-----LKKLYLGGNRISVVEgLENLTNLEELhienQRLPPG-EKLT-FDPRSLAALsNSLRVLNISGNNI 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209572589 302 KKIpSGLPELKYLQIIFLHSNSIARvgVNDFCPTVPKMkKSLYSaISLFNNPV----KYWE 358
Cdd:cd21340  133 DSL-EPLAPLRNLEQLDASNNQISD--LEELLDLLSSW-PSLRE-LDLTGNPVckkpKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
126-207 7.52e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 7.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  126 TSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPlnlpkslaelrihenkvkkiqKDTFKGMNALHVLEMSAN 205
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---------------------PGAFSGLPSLRYLDLSGN 59


                  ..
gi 209572589  206 PL 207
Cdd:pfam13855  60 RL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-340 1.09e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 143 PKAFLTTKKLRRLYLSHNQLSE------IPLNLPKSLAELRIHENKV-----KKIQKDTFKGMNALHVLEMSANPLDNNG 211
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPdgcgvlESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGAS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 212 IEPgafegvtvfhirIAEAkLTSVPKglpptLLELHLDYNKIS----TVELEDFKRYKELQRLGLGNNKITDIENGSLAN 287
Cdd:cd00116  154 CEA------------LAKA-LRANRD-----LKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 209572589 288 IPR----VREIHLENNKLK-----KIPSGLPEL-KYLQIIFLHSNSIARVGVNDFCPTVPKMK 340
Cdd:cd00116  216 TLAslksLEVLNLGDNNLTdagaaALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-289 3.21e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  84 RVVHCSDLGLTSVPTNIPFDTRM--LDLQNNKIKEIKEndFKGLTSLYGLILNNNKLTKIHPKAFLTtkKLRRLYLSHNQ 161
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 162 LSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPP 241
Cdd:COG4886  284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 209572589 242 TLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIP 289
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
154-324 1.21e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 154 RLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDtfkgmnaLH--VLEMSANpldnngiepgafegvtvfhiriaEAK 231
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN-------LQgnIKTLYAN-----------------------SNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 232 LTSVPKGLPPTLLELHLDYNKIstVELEDfKRYKELQRLGLGNNKITDIENgslaNIPR-VREIHLENNKLKKIPSGLPE 310
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRI--TELPE-RLPSALQSLDLFHNKISCLPE----NLPEeLRYLSVYDNSIRTLPAHLPS 304

                        170
                 ....*....|....
gi 209572589 311 lkYLQIIFLHSNSI 324
Cdd:PRK15370 305 --GITHLNVQSNSL 316
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-333 1.49e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 106 MLDLQNNKIK-EIKEndfkGLTS---LYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPLNLPKS--LAELRI 178
Cdd:PLN00113 360 VLDLSTNNLTgEIPE----GLCSsgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLplVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 179 HENKVKKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAFEGVTVFHIRIAEAKLT-SVPKGLP--PTLLELHLDYNKIST 255
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGslSELMQLKLSENKLSG 513

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 256 VELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK-KIPSGLPELKYLQII----------------F 318
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVnishnhlhgslpstgaF 593

                        250
                 ....*....|....*
gi 209572589 319 LHSNSIARVGVNDFC 333
Cdd:PLN00113 594 LAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
266-324 3.52e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.52e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 209572589  266 ELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIP----SGLPELKYLqiiFLHSNSI 324
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLPSLRYL---DLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
85-316 9.90e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 9.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  85 VVHCSDLGLTSVPTNIPFDTRMLDLQNNKikeikendfkgLTSLYGLilnnnkltkihpkafltTKKLRRLYLSHNQLSE 164
Cdd:PRK15387 205 VLNVGESGLTTLPDCLPAHITTLVIPDNN-----------LTSLPAL-----------------PPELRTLEVSGNQLTS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 165 IPLnLPKSLAELRIHENKVKKIQKDTfkgmNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEA-------------- 230
Cdd:PRK15387 257 LPV-LPPGLLELSIFSNPLTHLPALP----SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLpalpselcklwayn 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 231 -KLTSVPKgLPPTLLELHLDYNKISTVELEDfkryKELQRLGLGNNKITdiengSLANIPR-VREIHLENNKLKKIPSGL 308
Cdd:PRK15387 332 nQLTSLPT-LPSGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLT-----SLPALPSgLKELIVSGNRLTSLPVLP 401


                 ....*...
gi 209572589 309 PELKYLQI 316
Cdd:PRK15387 402 SELKELMV 409
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-175 1.56e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  84 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFltTKKLRRLYLSHNQLS 163
Cdd:PRK15370 328 KTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNL-PENL--PAALQIMQASRNNLV 401

                         90
                 ....*....|..
gi 209572589 164 EIPLNLPKSLAE 175
Cdd:PRK15370 402 RLPESLPHFRGE 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-263 1.75e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  84 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSlygLILNNNKLTKIhPKAFltTKKLRRLYLSHNQLS 163
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKT---LEAGENALTSL-PASL--PPELQVLDVSKNQIT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 164 EIPLNLPKSLAELRIHENKVKKIQKDTfkgMNALHVLEMSANPLdnngiepgafegvtvfhIRIAEAKLTSVPKGLPPTl 243
Cdd:PRK15370 360 VLPETLPPTITTLDVSRNALTNLPENL---PAALQIMQASRNNL-----------------VRLPESLPHFRGEGPQPT- 418

                        170       180
                 ....*....|....*....|
gi 209572589 244 lELHLDYNKISTVELEDFKR 263
Cdd:PRK15370 419 -RIIVEYNPFSERTIQNMQR 437
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-324 4.94e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589  95 SVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPLNLP--K 171
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGqmK 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 172 SLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAFEGVTVFH-IRIAEAKLT-SVPKGL--PPTLLELH 247
Cdd:PLN00113 213 SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL--TGPIPSSLGNLKNLQyLFLYQNKLSgPIPPSIfsLQKLISLD 290

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 209572589 248 LDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK-KIPSGLPELKYLQIIFLHSNSI 324
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-324 6.78e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 6.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 242 TLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKitdiengSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHS 321
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSN 145


                 ...
gi 209572589 322 NSI 324
Cdd:COG4886  146 NQL 148
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 234-325 3.08e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209572589 234 SVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKL-KKIPSGLPELK 312
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMK 212

                         90
                 ....*....|...
gi 209572589 313 YLQIIFLHSNSIA 325
Cdd:PLN00113 213 SLKWIYLGYNNLS 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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