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Conserved domains on  [gi|2095552615|gb|KAH0515080|]
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Transcriptional activator Myb [Microtus ochrogaster]

Protein Classification

transcriptional activator Myb family protein( domain architecture ID 16115925)

transcriptional activator Myb family protein

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 637-794 1.78e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 221.47  E-value: 1.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 637 FSPSQFLNTSSNHDNSGLDVPALTSTPLSGHK--LTTPCHRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 714
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKvfLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 715 QEIKYGPLKMLPQTPSHLVEDLQDVIKQesdESGIVAEFQEDGPPLLKKIKQEVESPTDKAGNFFCSNHWEGNSLSTQLF 794
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 206-308 2.35e-29

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 123.36  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 206 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 285
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|...
gi 2095552615 286 IAKLLPGRTDNAIKNHWNSTMRR 308
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 385-430 3.94e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


:

Pssm-ID: 462332  Cd Length: 47  Bit Score: 81.46  E-value: 3.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2095552615 385 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQ 430
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
157-205 1.80e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.49  E-value: 1.80e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  157 KTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 205
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 637-794 1.78e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 221.47  E-value: 1.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 637 FSPSQFLNTSSNHDNSGLDVPALTSTPLSGHK--LTTPCHRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 714
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKvfLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 715 QEIKYGPLKMLPQTPSHLVEDLQDVIKQesdESGIVAEFQEDGPPLLKKIKQEVESPTDKAGNFFCSNHWEGNSLSTQLF 794
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 206-308 2.35e-29

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 123.36  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 206 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 285
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|...
gi 2095552615 286 IAKLLPGRTDNAIKNHWNSTMRR 308
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLED 119
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 209-314 7.49e-27

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 110.17  E-value: 7.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 209 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIA 287
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100
                  ....*....|....*....|....*..
gi 2095552615 288 KLLPGRTDNAIKNHWNSTMRRNVEQEG 314
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKLLRQG 131
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 385-430 3.94e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 81.46  E-value: 3.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2095552615 385 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQ 430
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 212-270 1.55e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.05  E-value: 1.55e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2095552615 212 WTKEEDQRVIELVQKYGPKrWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 270
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
209-257 1.51e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.88  E-value: 1.51e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  209 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNP 257
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
157-205 1.80e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.49  E-value: 1.80e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  157 KTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 205
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 211-255 3.63e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 75.69  E-value: 3.63e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095552615 211 PWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHL 255
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 160-220 4.07e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 76.19  E-value: 4.07e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095552615 160 WTREEDEKLKKLVEQNGtDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRV 220
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 159-203 6.39e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.92  E-value: 6.39e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095552615 159 RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVL 203
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 637-794 1.78e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 221.47  E-value: 1.78e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 637 FSPSQFLNTSSNHDNSGLDVPALTSTPLSGHK--LTTPCHRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 714
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKvfLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 715 QEIKYGPLKMLPQTPSHLVEDLQDVIKQesdESGIVAEFQEDGPPLLKKIKQEVESPTDKAGNFFCSNHWEGNSLSTQLF 794
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 206-308 2.35e-29

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 123.36  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 206 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 285
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|...
gi 2095552615 286 IAKLLPGRTDNAIKNHWNSTMRR 308
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLED 119
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 209-314 7.49e-27

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 110.17  E-value: 7.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 209 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIA 287
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100
                  ....*....|....*....|....*..
gi 2095552615 288 KLLPGRTDNAIKNHWNSTMRRNVEQEG 314
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKLLRQG 131
PLN03091 PLN03091
hypothetical protein; Provisional
 206-314 4.23e-26

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 112.76  E-value: 4.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 206 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKhLKG--RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRW 283
Cdd:PLN03091   11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2095552615 284 AEIAKLLPGRTDNAIKNHWNSTMRRNVEQEG 314
Cdd:PLN03091   90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 385-430 3.94e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 81.46  E-value: 3.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2095552615 385 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQ 430
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 212-270 1.55e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.05  E-value: 1.55e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2095552615 212 WTKEEDQRVIELVQKYGPKrWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 270
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 209-255 1.06e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 77.16  E-value: 1.06e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095552615 209 KGPWTKEEDQRVIELVQKYGpKRWSVIAKHLKGRIGKQCRERWHNHL 255
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
209-257 1.51e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.88  E-value: 1.51e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  209 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNP 257
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
157-205 1.80e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.49  E-value: 1.80e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  157 KTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 205
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 261-304 2.47e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 76.00  E-value: 2.47e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2095552615 261 KTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNS 304
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 211-255 3.63e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 75.69  E-value: 3.63e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095552615 211 PWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHL 255
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 160-220 4.07e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 76.19  E-value: 4.07e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095552615 160 WTREEDEKLKKLVEQNGtDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRV 220
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 159-203 6.39e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.92  E-value: 6.39e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095552615 159 RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVL 203
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 157-203 3.21e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.92  E-value: 3.21e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095552615 157 KTRWTREEDEKLKKLVEQNGtDDWKVIANYLPNRTDVQCQHRWQKVL 203
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
261-308 2.79e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 67.63  E-value: 2.79e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095552615  261 KTSWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAIKNHWNSTMRR 308
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 263-303 4.81e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 66.83  E-value: 4.81e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2095552615 263 SWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAIKNHWN 303
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 264-318 2.26e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.24  E-value: 2.26e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2095552615 264 WTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRNVEQEGYLQE 318
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKE 55
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 211-253 3.09e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.56  E-value: 3.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2095552615 211 PWTKEEDQRVIELVQKYGPKRWSVIAKH---LKGRIGKQCRERWHN 253
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 205-251 3.97e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 47.30  E-value: 3.97e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095552615 205 PELIKGPWTKEEDQRVIELVQKYgPKRWSVIAKhLKGRIGKQCRERW 251
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLL-PTQWRTIAP-IVGRTAQQCLERY 45
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 155-204 1.48e-06

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 45.76  E-value: 1.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2095552615 155 LGKTRWTREEDEKLKKLVEQNGTdDWKVIANYLpNRTDVQCQHRWQKVLN 204
Cdd:cd11659     3 IKKTEWTREEDEKLLHLAKLLPT-QWRTIAPIV-GRTAQQCLERYNKLLD 50
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 152-301 4.09e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 50.17  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 152 KRHLGKTRWTREEDEKLKKLVEQNGTdDWKVIANYLPNRTDVQCQHRWQKVLNPELiKGPWTKEEDQRVIELVQ--KYGP 229
Cdd:COG5147    67 NPQLKKKNWSEEEDEQLIDLDKELGT-QWSTIADYKDRRTAQQCVERYVNTLEDLS-STHDSKLQRRNEFDKIDpfNENS 144

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095552615 230 KRWSVIAKhlkgrigKQCRERWHNHL------NPEVKKtSWTEEEDriiyqaHKRLGNRWAEIAKLLPGRTDNAIKNH 301
Cdd:COG5147   145 ARRPDIYE-------DELLEREVNREasyrlrVPRVSK-ADVKPRE------KGEENNPDIEDLQEMKELKSASITRH 208
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 159-199 4.50e-06

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 44.48  E-value: 4.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2095552615 159 RWTREEDEKLKKLVEQNGTDDWKVIANYLP---NRTDVQCQHRW 199
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKW 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 157-294 8.73e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 49.40  E-value: 8.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095552615 157 KTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGpKRWSVIA 236
Cdd:COG5147   239 KKGLSRKQFCERIWSTDRDEDKFWPNIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIG 317

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2095552615 237 KhLKGRIGKQCRERWHNHLNP--EVKKTSWT-EEEDRII-------YQAHKRLGNRWAEIAKLLPGRT 294
Cdd:COG5147   318 K-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDkvvnemrLEAQQSSRILWLLIAQNIRNRL 384
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 257-296 1.74e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 42.68  E-value: 1.74e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2095552615 257 PEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLpGRTDN 296
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 258-318 6.16e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.16  E-value: 6.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095552615 258 EVKKTSWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAIKNHWNSTMRRNVEQEGYLQE 318
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGpNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEE 78
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 212-262 6.45e-03

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 36.10  E-value: 6.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095552615 212 WTKEEDQRVI----ELVQKY-GPKR----WSVIAKHLK--G--RIGKQCRERWhNHLNPEVKKT 262
Cdd:cd12203     3 WPREETLSLIrlrrEMESRFqETKSkkalWEEIAAKMRelGynRSAKQCKEKW-ENLNKYYKKV 65
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 159-199 8.95e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 36.09  E-value: 8.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2095552615 159 RWTREEDEKLKKLVEQN-----------GTDDWKVIANYL----PNRTDVQCQHRW 199
Cdd:pfam13837   3 KWTEEETLALIEIWGERlelrfqeskkrNKKLWEEIAEKMaelgYNRSPEQCKEKW 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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