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Conserved domains on  [gi|2095533876|gb|KAH0501742|]
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Myb-related protein B [Microtus ochrogaster]

Protein Classification

myb-related protein( domain architecture ID 13851054)

myb-related protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain, binds DNA and functions as a transcription factor, such as human myb-related protein A that specifically recognizes the sequence 5'-YAAC[GT]G-3'

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 535-679 1.56e-55

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 1.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 535 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKY-PSFVTPD-QKYSMDNTPHTPTPFKNALE- 611
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKEnTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095533876 612 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDVRPEKQKRKPGlRRSPIKKVRKSLALDIVDEDG 679
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 super family cl33633
hypothetical protein; Provisional
 163-296 6.84e-30

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 6.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 163 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 240
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095533876 241 EIAKMLPGRTDNAVKNHWNSTIKRKVDTRGF-PNESrdcKPvylLLELED-KDRHQSA 296
Cdd:PLN03091   91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdPNTH---KP---LSEVENgEDKNPPT 142
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 116-176 4.66e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 4.66e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095533876 116 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 176
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 535-679 1.56e-55

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 1.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 535 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKY-PSFVTPD-QKYSMDNTPHTPTPFKNALE- 611
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKEnTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095533876 612 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDVRPEKQKRKPGlRRSPIKKVRKSLALDIVDEDG 679
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 PLN03091
hypothetical protein; Provisional
 163-296 6.84e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 6.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 163 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 240
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095533876 241 EIAKMLPGRTDNAVKNHWNSTIKRKVDTRGF-PNESrdcKPvylLLELED-KDRHQSA 296
Cdd:PLN03091   91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdPNTH---KP---LSEVENgEDKNPPT 142
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 162-277 8.26e-28

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 118.35  E-value: 8.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 162 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 241
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2095533876 242 IAKMLPGRTDNAVKNHWNSTIKRKVDTRGFPNESRD 277
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 116-176 4.66e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 4.66e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095533876 116 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 176
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 168-226 7.07e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 7.07e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2095533876 168 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 226
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
165-213 1.27e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.88  E-value: 1.27e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095533876  165 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 213
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 167-211 4.17e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 75.30  E-value: 4.17e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095533876 167 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 211
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
113-161 1.56e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.02  E-value: 1.56e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095533876  113 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 161
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 115-159 5.81e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 66.44  E-value: 5.81e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095533876 115 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 159
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 535-679 1.56e-55

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 1.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 535 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKY-PSFVTPD-QKYSMDNTPHTPTPFKNALE- 611
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKEnTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2095533876 612 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDVRPEKQKRKPGlRRSPIKKVRKSLALDIVDEDG 679
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 PLN03091
hypothetical protein; Provisional
 163-296 6.84e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 6.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 163 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 240
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2095533876 241 EIAKMLPGRTDNAVKNHWNSTIKRKVDTRGF-PNESrdcKPvylLLELED-KDRHQSA 296
Cdd:PLN03091   91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdPNTH---KP---LSEVENgEDKNPPT 142
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 162-277 8.26e-28

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 118.35  E-value: 8.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 162 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 241
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2095533876 242 IAKMLPGRTDNAVKNHWNSTIKRKVDTRGFPNESRD 277
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 165-322 1.50e-26

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 109.40  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 165 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKG-RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIA 243
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 244 KMLPGRTDNAVKNHWNSTIKRKVDTRGFPNESRdcKPvyllleLEDKDRHQSAQPMEGQGSlmagWPLAP-SAVKEDDSS 322
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTH--KP------LDANNIHKPEEEVSGGQK----YPIEPiSSSHTDDTT 172
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 116-176 4.66e-20

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 84.28  E-value: 4.66e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2095533876 116 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 176
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 168-226 7.07e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 7.07e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2095533876 168 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 226
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
165-213 1.27e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 76.88  E-value: 1.27e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095533876  165 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 213
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 165-211 3.99e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 75.62  E-value: 3.99e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095533876 165 KGPWTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHL 211
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 167-211 4.17e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 75.30  E-value: 4.17e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095533876 167 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 211
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 217-260 4.75e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.54  E-value: 4.75e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2095533876 217 KSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNS 260
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
113-161 1.56e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.02  E-value: 1.56e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095533876  113 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 161
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 115-159 5.81e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 66.44  E-value: 5.81e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2095533876 115 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 159
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 220-259 3.78e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 64.13  E-value: 3.78e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2095533876 220 WTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWN 259
Cdd:cd00167     2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
217-264 5.61e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 63.78  E-value: 5.61e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2095533876  217 KSCWTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWNSTIKR 264
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 113-159 1.14e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.91  E-value: 1.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095533876 113 KVKWTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVL 159
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 220-274 2.19e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.85  E-value: 2.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2095533876 220 WTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTRGFPNE 274
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKE 55
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 161-207 3.36e-08

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 50.39  E-value: 3.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2095533876 161 PDLVKGPWTKEEDQKVIELVKKYGTkQWTLIAKhLKGRLGKQCRERW 207
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPT-QWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 167-209 2.38e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.95  E-value: 2.38e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2095533876 167 PWTKEEDQKVIELVKKYGTKQWTLIAKH---LKGRLGKQCRERWHN 209
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 114-161 2.61e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 42.17  E-value: 2.61e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2095533876 114 VKWTHEEDEQLRALVRQFGQQDWKFLASHFP---NRTDQQCQYRWlRVLNP 161
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKW-RNLKK 50
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 213-252 7.03e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.14  E-value: 7.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2095533876 213 PEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLpGRTDN 252
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 113-263 1.12e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.55  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 113 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWL-----------------RVLNPDLVKGPWTKEEDQK 175
Cdd:COG5147   222 KKGETLALEQEINEYKEKKGLSRKQFCERIWSTDRDEDKFWPNIykklpyrdkksiykhlrRKYNIFEQRGKWTKEEEQE 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2095533876 176 VIELVKKYGtKQWTLIAKhLKGRLGKQCRERWHNHLNP--EVKKSCWT-EEEDRIIC-------EAHKVLGNRWAEIAKM 245
Cdd:COG5147   302 LAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDKvvnemrlEAQQSSRILWLLIAQN 379

                         170
                  ....*....|....*...
gi 2095533876 246 LPGRTDNAVKNHWNSTIK 263
Cdd:COG5147   380 IRNRLQHHCRDKYGVLIS 397
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 168-218 2.79e-03

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 36.87  E-value: 2.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2095533876 168 WTKEEDQKVI----ELVKKYGTKQ-----WTLIAKHLK--G--RLGKQCRERWhNHLNPEVKKS 218
Cdd:cd12203     3 WPREETLSLIrlrrEMESRFQETKskkalWEEIAAKMRelGynRSAKQCKEKW-ENLNKYYKKV 65
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 113-160 9.29e-03

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 34.98  E-value: 9.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2095533876 113 KVKWTHEEDEQLRALVRQFGQQdWKFLAShFPNRTDQQCQYRWLRVLN 160
Cdd:cd11659     5 KTEWTREEDEKLLHLAKLLPTQ-WRTIAP-IVGRTAQQCLERYNKLLD 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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