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Conserved domains on  [gi|2090556662]
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Chain C, Histone H2A

Protein Classification

histone H2A family protein( domain architecture ID 10049432)

histone H2A family protein similar to histone 2A (H2A) that is a core component of nucleosome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 16-103 1.08e-37

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


:

Pssm-ID: 467020  Cd Length: 89  Bit Score: 122.64  E-value: 1.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  16 KSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELA 95
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYAKRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKKRITPRHIQLAIRNDEELN 80


                  ....*...
gi 2090556662  96 TIFANVTI 103
Cdd:cd00074    81 KLFKGVTI 88
 
Name Accession Description Interval E-value
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 16-103 1.08e-37

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 122.64  E-value: 1.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  16 KSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELA 95
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYAKRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKKRITPRHIQLAIRNDEELN 80


                  ....*...
gi 2090556662  96 TIFANVTI 103
Cdd:cd00074    81 KLFKGVTI 88
PTZ00017 PTZ00017
histone H2A; Provisional
 13-108 2.40e-34

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 115.61  E-value: 2.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  13 SKMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACN-HRDKKsQKRIVPNHILTALRKD 91
Cdd:PTZ00017   15 KKPVSRSAKAGLQFPVGRVHRYLKKGRYAKRVGAGAPVYLAAVLEYLTAEVLELAGNaAKDNK-KKRITPRHIQLAIRND 93

                          90
                  ....*....|....*..
gi 2090556662  92 KELATIFANVTIREGGV 108
Cdd:PTZ00017   94 EELNKLLAGVTIASGGV 110
H2A smart00414
Histone 2A;
17-109 6.33e-34

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 113.97  E-value: 6.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662   17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNH-RDKKSqKRIVPNHILTALRKDKELA 95
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKGTYAKRVGAGAPVYLAAVLEYLTAEVLELAGNAaRDNKK-RRITPRHLQLAIRNDEELN 79

                           90
                   ....*....|....
gi 2090556662   96 TIFANVTIREGGVA 109
Cdd:smart00414  80 KLLKGVTIAQGGVL 93
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
17-127 3.15e-27

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 97.63  E-value: 3.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELAT 96
Cdd:COG5262    18 SRSAKAGLIFPVGRVKRLLKKGNYRMRIGAGAPVYLAAVLEYLAAEILELAGNAARDNKKKRIIPRHLQLAIRNDEELNK 97

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2090556662  97 IFANVTIREGGVARSAKEG----REGKGSHRSQDL 127
Cdd:COG5262    98 LLGDVTIAQGGVLPNINPGllpkSSKKGSKRSQEL 132
Histone pfam00125
Core histone H2A/H2B/H3/H4;
14-91 2.49e-07

Core histone H2A/H2B/H3/H4;


Pssm-ID: 459682 [Multi-domain]  Cd Length: 126  Bit Score: 46.27  E-value: 2.49e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2090556662  14 KMKSRSARAGISFPIGRIHRHLREGRYAE-RISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKD 91
Cdd:pfam00125  48 KYQSSTDLLIYKLPFARVVREVVQSTKTDlRISADAVVALQEAVEDFLVELFEEANLLAIHAKRVTLTPKDIQLARRLR 126
 
Name Accession Description Interval E-value
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 16-103 1.08e-37

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 122.64  E-value: 1.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  16 KSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELA 95
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYAKRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKKRITPRHIQLAIRNDEELN 80


                  ....*...
gi 2090556662  96 TIFANVTI 103
Cdd:cd00074    81 KLFKGVTI 88
PTZ00017 PTZ00017
histone H2A; Provisional
 13-108 2.40e-34

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 115.61  E-value: 2.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  13 SKMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACN-HRDKKsQKRIVPNHILTALRKD 91
Cdd:PTZ00017   15 KKPVSRSAKAGLQFPVGRVHRYLKKGRYAKRVGAGAPVYLAAVLEYLTAEVLELAGNaAKDNK-KKRITPRHIQLAIRND 93

                          90
                  ....*....|....*..
gi 2090556662  92 KELATIFANVTIREGGV 108
Cdd:PTZ00017   94 EELNKLLAGVTIASGGV 110
H2A smart00414
Histone 2A;
17-109 6.33e-34

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 113.97  E-value: 6.33e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662   17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNH-RDKKSqKRIVPNHILTALRKDKELA 95
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKGTYAKRVGAGAPVYLAAVLEYLTAEVLELAGNAaRDNKK-RRITPRHLQLAIRNDEELN 79

                           90
                   ....*....|....
gi 2090556662   96 TIFANVTIREGGVA 109
Cdd:smart00414  80 KLLKGVTIAQGGVL 93
PLN00157 PLN00157
histone H2A; Provisional
 14-108 8.47e-31

histone H2A; Provisional


Pssm-ID: 177758  Cd Length: 132  Bit Score: 106.86  E-value: 8.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  14 KMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACN-HRDKKsQKRIVPNHILTALRKDK 92
Cdd:PLN00157   15 KATSRSAKAGLQFPVGRIARYLKAGKYATRVGAGAPVYLAAVLEYLAAEVLELAGNaARDNK-KSRIVPRHIQLAVRNDE 93

                          90
                  ....*....|....*.
gi 2090556662  93 ELATIFANVTIREGGV 108
Cdd:PLN00157   94 ELSKLLGGVTIAAGGV 109
PLN00156 PLN00156
histone H2AX; Provisional
 13-108 3.66e-28

histone H2AX; Provisional


Pssm-ID: 215080  Cd Length: 139  Bit Score: 100.43  E-value: 3.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  13 SKMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDK 92
Cdd:PLN00156   17 TKSVSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKKNRIVPRHIQLAVRNDE 96

                          90
                  ....*....|....*.
gi 2090556662  93 ELATIFANVTIREGGV 108
Cdd:PLN00156   97 ELSKLLGSVTIAAGGV 112
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
17-127 3.15e-27

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 97.63  E-value: 3.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELAT 96
Cdd:COG5262    18 SRSAKAGLIFPVGRVKRLLKKGNYRMRIGAGAPVYLAAVLEYLAAEILELAGNAARDNKKKRIIPRHLQLAIRNDEELNK 97

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2090556662  97 IFANVTIREGGVARSAKEG----REGKGSHRSQDL 127
Cdd:COG5262    98 LLGDVTIAQGGVLPNINPGllpkSSKKGSKRSQEL 132
PLN00153 PLN00153
histone H2A; Provisional
 14-124 1.05e-26

histone H2A; Provisional


Pssm-ID: 165721 [Multi-domain]  Cd Length: 129  Bit Score: 96.33  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  14 KMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKE 93
Cdd:PLN00153   13 KAVSRSAKAGLQFPVGRIARYLKKGKYAERIGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKNRIVPRHIQLAIRNDEE 92

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2090556662  94 LATIFANVTIREGGVARS------AKEGREGKGSHRS 124
Cdd:PLN00153   93 LGKLLGEVTIASGGVLPNihavllPKKTKGGKGEETA 129
PLN00154 PLN00154
histone H2A; Provisional
 10-108 2.49e-19

histone H2A; Provisional


Pssm-ID: 177756  Cd Length: 136  Bit Score: 77.68  E-value: 2.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  10 KDNSKMKSRSARAGISFPIGRIHRHLREGRYAE-RISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTAL 88
Cdd:PLN00154   23 KDKKKPTSRSSRAGLQFPVGRIHRQLKQRVSAHgRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAI 102

                          90       100
                  ....*....|....*....|
gi 2090556662  89 RKDKELATIFaNVTIREGGV 108
Cdd:PLN00154  103 RGDEELDTLI-KGTIAGGGV 121
PTZ00252 PTZ00252
histone H2A; Provisional
 17-121 4.36e-18

histone H2A; Provisional


Pssm-ID: 240330  Cd Length: 134  Bit Score: 74.23  E-value: 4.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662  17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFR---EACNHRDKKsQKRIVPNHILTALRKDKE 93
Cdd:PTZ00252   17 GRSAKAGLIFPVGRVGSLLRRGQYARRIGASGAVYMAAVLEYLTAELLElsvKAAAQQAKK-PKRLTPRTVTLAVRHDDD 95

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2090556662  94 LATIFANVTIREGGV--------ARSAKEGREGKGS 121
Cdd:PTZ00252   96 LGSLLKNVTLSRGGVmpslnkalAKKHKSGKKAKAT 131
PLN00155 PLN00155
histone H2A; Provisional
 14-57 5.31e-15

histone H2A; Provisional


Pssm-ID: 165723  Cd Length: 58  Bit Score: 64.34  E-value: 5.31e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2090556662  14 KMKSRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLE 57
Cdd:PLN00155   13 KAVSRSAKAGLQFPVGRIARYLKKGKYAERIGAGAPVYLAAVLE 56
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 17-69 1.29e-12

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


Pssm-ID: 467038  Cd Length: 105  Bit Score: 59.24  E-value: 1.29e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2090556662  17 SRSARAGISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACN 69
Cdd:cd22913    10 SKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALA 62
HFD_SOS1_rpt2 cd22915
second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; ...
 25-98 2.19e-08

second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; SOS-1 is a guanine nucleotide exchange factor for Ras that binds to GRB2. It promotes the exchange of Ras-bound GDP by GTP. It is a catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac, by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. SOS-1 contains tandem histone folds at the N-terminal region. The model corresponds to the second repeat.


Pssm-ID: 467040  Cd Length: 75  Bit Score: 47.62  E-value: 2.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2090556662  25 SFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKDKELATIF 98
Cdd:cd22915     1 LFPVDKIHPLLKKDLLVYKVDPQVSLYLVAVLEYIAADILKLAGNYVRNIRHYEITSQDIKVAMCADKVLMDLF 74
Histone pfam00125
Core histone H2A/H2B/H3/H4;
14-91 2.49e-07

Core histone H2A/H2B/H3/H4;


Pssm-ID: 459682 [Multi-domain]  Cd Length: 126  Bit Score: 46.27  E-value: 2.49e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2090556662  14 KMKSRSARAGISFPIGRIHRHLREGRYAE-RISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPNHILTALRKD 91
Cdd:pfam00125  48 KYQSSTDLLIYKLPFARVVREVVQSTKTDlRISADAVVALQEAVEDFLVELFEEANLLAIHAKRVTLTPKDIQLARRLR 126
CBFD_NFYB_HMF pfam00808
Histone-like transcription factor (CBF/NF-Y) and archaeal histone; This family includes ...
 24-88 9.62e-07

Histone-like transcription factor (CBF/NF-Y) and archaeal histone; This family includes archaebacterial histones and histone like transcription factors from eukaryotes.


Pssm-ID: 395650  Cd Length: 65  Bit Score: 42.98  E-value: 9.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2090556662  24 ISFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREA---CNHRDKKSqkrIVPNHILTAL 88
Cdd:pfam00808   1 AELPIARVKRIMKSDPDAGRISQDAKELIAECVEEFIEFVASEAaeiCNKAGRKT---INPEHIKQAV 65
BUR6 COG5247
Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription];
3-95 4.35e-04

Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription];


Pssm-ID: 227572  Cd Length: 113  Bit Score: 37.25  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2090556662   3 HMSTKPvKDNSKMKSRSaragiSFPIGRIHRHLREGRYAERISSDAPVYLAAVLENVVAEVFREACNHRDKKSQKRIVPN 82
Cdd:COG5247     7 NMGTMP-KQNSQKKKKT-----RFPIARLKKIMQLDEDIGKVGQSTPVIASKALEMFLTEIVGLSLKEARKKSSKRMTSE 80

                          90
                  ....*....|...
gi 2090556662  83 HILTALRKDKELA 95
Cdd:COG5247    81 FLKRATESDEKFD 93
HHT1 COG2036
Archaeal histone H3/H4 [Chromatin structure and dynamics];
26-74 8.21e-03

Archaeal histone H3/H4 [Chromatin structure and dynamics];


Pssm-ID: 441639  Cd Length: 67  Bit Score: 32.88  E-value: 8.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2090556662  26 FPIGRIHRHLREGRyAERISSDAPVYLAAVLENVVAEVFREA---CNHRDKK 74
Cdd:COG2036     2 LPVAPVDRIIKKAG-AERVSEDAVEALAEILEEYAEEIAKEAvelAKHAGRK 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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