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Conserved domains on  [gi|2089723640|gb|QZX51334|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, partial [Edaphochlamys debaryana]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-300 8.90e-74

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 229.24  E-value: 8.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  43 TIKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyALADTLTCSDPTIPSDDSNLVIKALNLYRRKTL 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 123 QSMYFNVKLTKRVPHgaglgggSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDVAP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLADIAAAGGVDQAAAVNDLEQPAFDNLPTLAALKQRLLDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723640 282 GAfRSVFMTGSGSTivCFG 300
Cdd:COG1947   238 GA-LAARMSGSGST--VFG 253
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-300 8.90e-74

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 229.24  E-value: 8.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  43 TIKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyALADTLTCSDPTIPSDDSNLVIKALNLYRRKTL 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 123 QSMYFNVKLTKRVPHgaglgggSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDVAP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLADIAAAGGVDQAAAVNDLEQPAFDNLPTLAALKQRLLDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723640 282 GAfRSVFMTGSGSTivCFG 300
Cdd:COG1947   238 GA-LAARMSGSGST--VFG 253
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 43-296 8.94e-40

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 141.88  E-value: 8.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  43 TIKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYALAdTLTCSDPTIPsDDSNLVIKALNLYRRKTL 122
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDI-RLLKGDFDVP-LEENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 123 QSMY----FNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVE 198
Cdd:TIGR00154  80 SKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 199 DVapPVPLDTPMLLVKPPVGLSTPRIFKSLDLARrsTADPRVLLADIAAAGGVDQAAA---VNDLEQPAFDNLPTLAALK 275
Cdd:TIGR00154 160 PF--EDPPEKWVVIAKPHVSVSTPVVYQAYKLPR--NTPKRAKEWLKKISLECLQLLDsngLNDLEKVALKRHTEVAQAL 235

                         250       260
                  ....*....|....*....|.
gi 2089723640 276 QRLLDSGAfRSVFMTGSGSTI 296
Cdd:TIGR00154 236 NWLLEYGL-APERMSGSGPCV 255
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
44-301 7.87e-34

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 125.64  E-value: 7.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  44 IKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMeFTTTPYALadTLTCSDPTIPSDDsNLVIKALNLYRRKTLQ 123
Cdd:PRK14611    2 EVLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRI-YIKEHHTL--EVKTSSPQIKEEE-NIVYKALRLFERYTGI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 124 SMYFNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDVapP 203
Cdd:PRK14611   78 DINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFL--E 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 204 VPLDTPMLLVKPPVGLSTPRIFKSLDLARRSTADPRVLLADIAAAGGVDQAAAV--NDLEQPAFDNLPTLAALkQRLLDS 281
Cdd:PRK14611  156 KPISREITLVYPNIKSSTGRVYSKVTKQILTNKEDLNIIISLLREGEEKKIEEVieNTLGEIALELYPEIKEV-YRFLEY 234

                         250       260
                  ....*....|....*....|
gi 2089723640 282 GAFRSvFMTGSGSTIVCFGS 301
Cdd:PRK14611  235 LGYKP-FVSGSGSSVYVFGK 253
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 43-300 8.90e-74

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 229.24  E-value: 8.90e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  43 TIKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyALADTLTCSDPTIPSDDSNLVIKALNLYRRKTL 122
Cdd:COG1947     1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPAD-DGSISLTGPGAGVPTDEDNLVYRAARLLQEATG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 123 QSMYFNVKLTKRVPHgaglgggSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDVAP 202
Cdd:COG1947    80 IPPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 203 PVPLdtPMLLVKPPVGLSTPRIFKSLDLARRSTA-DPRVLLADIAAAGGVDQAAAVNDLEQPAFDNLPTLAALKQRLLDS 281
Cdd:COG1947   160 LPEL--WLVLVKPGVGVSTAEVYRALDLTRDTPPpDIDALLAALAAGDAALAALLRNDLEPVAFKLYPEIAEVLEALLEA 237

                         250
                  ....*....|....*....
gi 2089723640 282 GAfRSVFMTGSGSTivCFG 300
Cdd:COG1947   238 GA-LAARMSGSGST--VFG 253
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 43-296 8.94e-40

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 141.88  E-value: 8.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  43 TIKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYALAdTLTCSDPTIPsDDSNLVIKALNLYRRKTL 122
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDI-RLLKGDFDVP-LEENLAYRAAQLLKNFAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 123 QSMY----FNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVE 198
Cdd:TIGR00154  80 SKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 199 DVapPVPLDTPMLLVKPPVGLSTPRIFKSLDLARrsTADPRVLLADIAAAGGVDQAAA---VNDLEQPAFDNLPTLAALK 275
Cdd:TIGR00154 160 PF--EDPPEKWVVIAKPHVSVSTPVVYQAYKLPR--NTPKRAKEWLKKISLECLQLLDsngLNDLEKVALKRHTEVAQAL 235

                         250       260
                  ....*....|....*....|.
gi 2089723640 276 QRLLDSGAfRSVFMTGSGSTI 296
Cdd:TIGR00154 236 NWLLEYGL-APERMSGSGPCV 255
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
44-301 7.87e-34

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 125.64  E-value: 7.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  44 IKLFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMeFTTTPYALadTLTCSDPTIPSDDsNLVIKALNLYRRKTLQ 123
Cdd:PRK14611    2 EVLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRI-YIKEHHTL--EVKTSSPQIKEEE-NIVYKALRLFERYTGI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 124 SMYFNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDVapP 203
Cdd:PRK14611   78 DINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFL--E 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 204 VPLDTPMLLVKPPVGLSTPRIFKSLDLARRSTADPRVLLADIAAAGGVDQAAAV--NDLEQPAFDNLPTLAALkQRLLDS 281
Cdd:PRK14611  156 KPISREITLVYPNIKSSTGRVYSKVTKQILTNKEDLNIIISLLREGEEKKIEEVieNTLGEIALELYPEIKEV-YRFLEY 234

                         250       260
                  ....*....|....*....|
gi 2089723640 282 GAFRSvFMTGSGSTIVCFGS 301
Cdd:PRK14611  235 LGYKP-FVSGSGSSVYVFGK 253
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 47-300 5.32e-33

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 123.81  E-value: 5.32e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  47 FSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPyalADTLTCSDPT---IPSDDSNLVIKALNLYRRKT-- 121
Cdd:PRK14608   10 FAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAE---ALSLTVSGPFaagLGDGDDNLVLRAARALRARVgp 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 122 -LQSMYFnvKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVEDV 200
Cdd:PRK14608   87 gLPPGAF--HLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELTPL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 201 APPVPLdtPMLLVKPPVGLSTPRIFKSLDLaRRSTADPRVLLADIAAAGGVDQ-AAAVNDLEQPAFDNLPTLAALKQRLL 279
Cdd:PRK14608  165 PGLPSL--PAVLVNPGVPVATPDVFRALGL-RDGPPLPGAPDPLASADALLAAlAATRNDLEPPALALAPVIGEVLAALR 241

                         250       260
                  ....*....|....*....|.
gi 2089723640 280 DSGAFRSVFMTGSGSTivCFG 300
Cdd:PRK14608  242 AQPGALLARMSGSGAT--CFA 260
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 49-297 3.06e-30

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 116.53  E-value: 3.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  49 PSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYAladTLTCSDP---TIPSDDSNLVIKALNLYRRKTLQSM 125
Cdd:PRK03188    6 PAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVL---SVEVSGEgadQVPTDESNLAWRAAELLAEHVGRAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 126 YFNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSKGAAYCTGRGEVVedvappvp 205
Cdd:PRK03188   83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQL-------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 206 ldTPML--------LVKPPVGLSTPRIFKSLDLARRSTADPRVLLAD--IAA--AGGVDQAAAV--NDLEQPAFDNLPTL 271
Cdd:PRK03188  155 --APVLargtfhwvLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDplLAAlrAGDPAQLAPLlgNDLQAAALSLRPSL 232

                         250       260
                  ....*....|....*....|....*.
gi 2089723640 272 AALKQRLLDSGAFRSVfMTGSGSTIV 297
Cdd:PRK03188  233 RRTLRAGEEAGALAGI-VSGSGPTCA 257
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
46-296 1.51e-17

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 81.87  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  46 LFSPSKINLFLRVVRRREDGYHDLASLFHVIDLGDEMEFTTTPYALADTLTCSD------------PTIPSDDSNLVIKA 113
Cdd:PRK14613    1 MISPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFSTNEiilekrklydqvSERGDIKQNILYKT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 114 LNLYRRKTLQSMYFNVKLTKRVPHGAGL---GGGSGNAATTLFAANKLMGSpvsnDELLEWSGEIGSDISVFFSKGAAYC 190
Cdd:PRK14613   81 FIKARSLFPELPGVKIHLTKRISPAGGLgggSTNAASLLNFLFSWRNFFTS----DEMQVFAKEIGSDVPFFLGEGHAFV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 191 TGRGEVVEdvapPVPLDTPM-LLVKPPVGLSTPRIFKSLDLARRSTADPRV-------LLADIAAAGGVD-QAAAVNDLE 261
Cdd:PRK14613  157 TGKGEIME----EIEVHKGQgILALTPQVMNTGEMYALLKKPLQESASQKNgntlsedLISSLKVGDWVSlQGRLENDFE 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2089723640 262 QPAFDNLPTLAALKQRLLDSGA-FRSvfMTGSGSTI 296
Cdd:PRK14613  233 PVAFQLHPELGVLKDKFLEFGSsYCS--LTGSGSSM 266
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 51-295 1.86e-12

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 66.52  E-value: 1.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  51 KINLFLRVVRRReDGYHDLASLF-HVIDLGDEMEFTTT---PYALADTLTCSDptipsdDSNLVIKALNLYRRKTLQ--- 123
Cdd:PRK04181    8 KVNIFLKILGKR-GNYHELISRFvLVKDLFDEIEFVPKsaeSFELIGNFDCPL------EENIIYKAYQELKNKGFSnel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 124 --SMYFN-VKLTKRVPHGAGLGGGSGNAATTLFAANKLMGSPVSNDELLEWSGEIGSDISVFFSK-GAAYCTGRGEVVEd 199
Cdd:PRK04181   81 ieFFKKKaIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVE- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 200 vappvPLDTPML---LVKPPVGLSTPRIFK----------SLDLARR-STADPRVLLADIaaaggvdQAAAVNDLEQPAF 265
Cdd:PRK04181  160 -----EFEEEILnleIFTPNIFCSTKAVYKayreefydfiSFNQAKElLKLSSLELLKNF-------KNTELNDLLAPAL 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 2089723640 266 DNLPTLAalkqrlldSGAFRSVFMTGSGST 295
Cdd:PRK04181  228 KLYPALK--------DYLGEDWFFSGSGSS 249
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
48-299 1.58e-08

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 54.85  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  48 SPSKINLFLRVVRRRED-GYHDLASLFHVI-DLGDEMEFTTTPYALaDTLTCSDPT----IPSDDsnLVIKALNLYRRKT 121
Cdd:PRK05905    5 SYAKINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEIEKIEKNI-DDIHYFDETneilVYSRL--ILVKTLEWLRDKY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 122 LQSMYFNVKLTKRVPHGAGLGGGSGNAATTLFAANKLMG-SPVSNDELLEwsgEIGSDIsVFFSKG--AAYCTGRGEVVE 198
Cdd:PRK05905   82 NIKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEFEGiNEINYKDVVN---KLGSDI-PFFLSGykTAYISDYGSQVE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 199 DVAPPVPLDTPMLLVKppVGLSTPRIFKSLDLARRSTADPrvLLADIAAAGGVDQAAAVNDLEQPAFDNLPTLAALKQRL 278
Cdd:PRK05905  158 DLIGQFKLTYKVIFMN--VNVSTKKVFEKFDDNQHVIKNN--FKTIIKNLKENIVVNIHNDLQEPCFELYPNLLYKYNEL 233

                         250       260
                  ....*....|....*....|.
gi 2089723640 279 LDSGAFrsVFMTGSGSTIVCF 299
Cdd:PRK05905  234 LNDGFY--TILSGAGSSFIVI 252
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 76-302 1.49e-07

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 52.02  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640  76 IDLGDEMEFTTTPyalADTLT-----CSDPTIPSDDSNLVIKALNLYRRKTLQSMY-FNVKLTKRVPHgaglgggsgnaa 149
Cdd:COG0083    25 LSLYDEVEVERSD---EPGLEieiegEGADELPTDEDNLVYQAALALLEKLGKEPPgLRIEIEKGIPL------------ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 150 tT-------------LFAANKLMGSPVSNDELLEWSGEI------------GsdisvffskGAAYCTGRGEVVEDVAPPV 204
Cdd:COG0083    90 -GrglgssaaaivagLVAANALLGLPLSKEELLELATEGeghpdnvapallG---------GLVLSRSDGEPVRVVRLPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 205 PLDTPMLLVKPPVGLSTprifkslDLARrstadpRVL-----LADIAAAGGvdQAAAV------NDLE-----------Q 262
Cdd:COG0083   160 PPDLKAVVVIPDFELST-------KEAR------AVLpkqvpLKDAVFNSS--RAALLvaalatGDYEllgramedrlhE 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2089723640 263 PA-FDNLPTLAALKQRLLDSGAFrSVFMTGSGSTIVCFGSD 302
Cdd:COG0083   225 PYrAKLIPGFDEVKEAALEAGAL-GAGISGAGPTVLALADD 264
PRK01212 PRK01212
homoserine kinase; Provisional
 102-175 2.49e-03

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 38.98  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089723640 102 IPSD-DSNLVIKALNLYRRKTLQSMYFNVKLTKRVPHgaglgggsgnaaT------------TLFAANKLMGSPVSNDEL 168
Cdd:PRK01212   56 LPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPL------------GrglgssaasivaGLVAANELAGLPLSKEEL 123


                  ....*..
gi 2089723640 169 LEWSGEI 175
Cdd:PRK01212  124 LQLATEG 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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