|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
346-916 |
2.43e-74 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 260.75 E-value: 2.43e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 346 LSIGFFLMFFYVLV-----ISSEYNWVGCRVYLTIVGLLCVGGAFIVSISVCSLLGISYGPVHTSLPFLLLALGVDDNFL 420
Cdd:pfam02460 219 FVIGFFLLLTFSIIvsvtlSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 421 IMASWkevhaQKLNRNKPLEKRIALMLGHAGSAIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVA 500
Cdd:pfam02460 299 MVAAW-----QRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAA 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 501 FFSIDARRIENKRNSIFPCIIHENFTQKFINPQEEFSTKLIN-------KIYSNIILTKLGKITIVLITIVTASVGLVGI 573
Cdd:pfam02460 374 IMAICAKPEAEGRHCLFVWATSSPQRIDSEGSEPDKSHNIEQlksrfflDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGC 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 574 LQLQQWFDPTWFIPNHSYLSKYINVHRAEYPDRGYESMILM---GDFNYTAEFPKLINLSEKFANLSTI---QSISAWPI 647
Cdd:pfam02460 454 VNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPEGLQIQVAVnnpPNLTIPESRDRMNEMVDEFENTPYSlgpNSTLFWLR 533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 648 DFTKFVLE-----------HFQKDLRNVILEDTEFQNYLSKFLFSRNGGKYQRnFRFKKSLicgqntapisvatidfifK 716
Cdd:pfam02460 534 EYENFLSTlnmeeeedeekEWSYGNLPSFLKAPGNSHWAGDLVWDDNTTMVTK-FRFTLAG------------------K 594
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 717 RFYGPHQWIPAMDESKQVA-REVGINgfVTVWSEIFSLWVTDKLIAQEVQRNVLLALICVMGMTGLLIAELQTCFWIFLS 795
Cdd:pfam02460 595 GLSTWNDRTRALQEWRSIAdQYPEFN--VTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLA 672
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 796 VLLTLLNVCGFMYFWNLTIDIVSCIGLELGIGLCVDYAAHVAHAFINAacidGSEDRTKRAHIAVRYIGAAVAYGAGSTL 875
Cdd:pfam02460 673 IASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRS----RGDTPAERVVDALEALGWPVFQGGLSTI 748
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 2088136601 876 LALSMMAFSESYVFHAFLKIFVLVILFGLWHGLFLLPVILS 916
Cdd:pfam02460 749 LGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILS 789
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
22-919 |
8.52e-58 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 216.70 E-value: 8.52e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 22 QRLSEVVEHFFYELGLRIARSPLKWIIGSAVIVLISLSGLYFFHQEKNPIRLWVPQDSEFVRDTEWMFEKFDQSLRLENM 101
Cdd:TIGR00917 303 STVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQL 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 102 ILTADN---------ILEPEILAKLNEITKQIISIQT---PDQIAWTDICFKvpvisgiahrtkrsdqsddffeiepevl 169
Cdd:TIGR00917 383 IIATVQtsshekapeILTDDNLKLLFDIQKKVSQLFAnyeGELITLDSPCFK---------------------------- 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 170 inktifepavhanpelychivNNLPKACLLNSILDIWEYDTNVILHKSKEEIIKDI-----NKIKISP-----TLGHPLN 239
Cdd:TIGR00917 435 ---------------------PNHPYNCFIYSTCKKLQNMYSKLKPENYDDYGGVDyvkycFEHFTSPesclsAFGGPVD 493
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 240 FTELLGGIikdENDRIISATAvktqwaIIVNFSEVDMHDFGNDVGTAdwatkdiLQWELSYLNvlhrnakLLNSEKNVNN 319
Cdd:TIGR00917 494 PTTVLGGF---SGNNFSEASA------FVVTFPVNNFVNKTNKTEKA-------VAWEKAFIQ-------LAKDELLPMV 550
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 320 TLAIWYEAGRSFGDVTFVTMFGNIGILSIGFFLMFFYV-----LVISSEYNWVGCRVYLTIVGLLCVGGAFIVSISVCSL 394
Cdd:TIGR00917 551 QATISFSAERSIEDELKRESTADVITIAISYLVMFAYIsltlgDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSA 630
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 395 LGI-SYGPVHTSLPFLLLALGVDDNFLIMASWKEVH---AQKLNRNK---PLEKRIALMLGHAGSAIIITSLTDVVAFII 467
Cdd:TIGR00917 631 VGLkSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEyfyRQVGVDNEqelTLERRLSRALMEVGPSITLASLSEILAFAL 710
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 468 GASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARRIENKRNSIFPCIIHE---NFTQKFINPQEE-FSTKLINK 543
Cdd:TIGR00917 711 GALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSkssISAEKGSGQRKAgLLTRYFKE 790
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 544 IYSNIILTKLGKITIVLITIVTASVGLVGILQLQQWFDPTWFIPNHSYLSKYINvHRAEYPDRGYESMI-LMGDFNYTAE 622
Cdd:TIGR00917 791 VYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFA-SLTPLLEVGPPFYIvIKGDYNYTDF 869
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 623 FPKLI----------NLSEKFANLSTI-QSISAWPIDFTKFV-------LEHFQKDLRNVILED---------------- 668
Cdd:TIGR00917 870 ESQNKlctmggcdkdSIVNVFNNLSYIaKPASSWLDDYLVWLspqasccCRKFTNGTFCNGPDPqcfrcadlssdaqgrp 949
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 669 --TEFQNYLSKFLFSRNGGKYQR-NFRFKKSLICGQNTAPISVATidfifkRFYGPH-------QWIPAMDESKQVAREV 738
Cdd:TIGR00917 950 stTQFKEKLPWFLNALPSADCAKgGHAAYSSAVDLQGYATIIQAS------SFRTYHtplntqvDFINAMRAAQEFAAKV 1023
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 739 GINGF--VTVWSEIFSLWVTDKLIAQEVQRNVLLALICVMGMTGLLIA-ELQTCFWIFLSVLLTLLNVCGFMYFWNLTID 815
Cdd:TIGR00917 1024 SRSSKmeVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHLWSISLN 1103
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 816 IVSCIGLELGIGLCVDYAAHVAHAFINAAcidgSEDRTKRAHIAVRYIGAAVAYGAGST-LLALSMMAFSESYVFHAF-L 893
Cdd:TIGR00917 1104 AVSVVNSVMHKGIAIEFCTHINAQFSTGK----HFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYyF 1179
|
970 980
....*....|....*....|....*.
gi 2088136601 894 KIFVLVILFGLWHGLFLLPVILSTIG 919
Cdd:TIGR00917 1180 RMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
366-520 |
4.14e-39 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 142.34 E-value: 4.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 366 WVGCRVYLTIVGLLCVGGAFIVSISVCSLLGISYGPVHTS-LPFLLLALGVDDNFLIMASWkevhaQKLNRNKPLEKRIA 444
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEvIPFLVLAIGVDNIFLLVKAV-----VRTPRSLDVSERIA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2088136601 445 LMLGHAGSAIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARRIENKRNSIFPCI 520
Cdd:pfam12349 76 EALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCI 151
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
243-932 |
5.45e-35 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 144.64 E-value: 5.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 243 LLGGIIKDENDRIISATAVKTQWAIIvnfSEVDMHDF--GND-VGTADWATK---DILQ-WELSYLNVLHRNAKLLNSEK 315
Cdd:TIGR00918 302 IVGGTKRNRSGKLLSAQALQSMFQLM---TPKQMYEHfkGYYkVHHIGWNEEkaaAVLEaWQRNFSEEVQQSLPKNSSQK 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 316 NVNNTLAIWYEAGRSFGDVTFVTmfgnigiLSIGFFLMFFYVLVISSEYNWVGCRVYLTIVGLLCVGGAFIVSISVCSLL 395
Cdd:TIGR00918 379 ILVFSSTTLDDILKKFSDVSAIR-------IVSGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALL 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 396 GISYGPVHTS-LPFLLLALGVDDNFLIMASWKEVhaqklNRNKPLEKRIALMLGHAGSAIIITSLTDVVAFIIGASTILP 474
Cdd:TIGR00918 452 GISFNAATTQvLPFLALGVGVDDVFLLAHAFSET-----GQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIP 526
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 475 SLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARRIENKRNSIFPCIIHENFTQKF-INPQE------------------- 534
Cdd:TIGR00918 527 ALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPCSARVIqIEPQAyadgsappvysshmqstvq 606
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 535 ----------------------------------------------EFSTKLIN----------------KIYSNIILTK 552
Cdd:TIGR00918 607 lrteydpgtqhyyttneprshlsvqpsdplscqspdiagstrdllsQFEDSKAAclslpcarwtlatfaeKHYAPFLLQS 686
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 553 LGKITIVLITIVTASVGLVGILQLQQWFDPTWFIPNHSYLSKYInvhRAEYPDRGYESMILM--GDFNYTAEFPKLINLS 630
Cdd:TIGR00918 687 WAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFL---DAQFRYFSFYNMYAVtqGNFDYPTQQQLLYDLH 763
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 631 EKFANLSTI------QSISAWPIDFTKFVL---EHFQKDLR--------------NVIL------------EDTEFQNYL 675
Cdd:TIGR00918 764 QSFSSVKYVlkedngQLPRMWLHYFRDWLQglqKAFDEDWRdgritkenyrngsdDAVLaykllvqtghrdKPVDKEQLT 843
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 676 SKFLFSRNG----------------------GKYQRNFR-------FKKSLICGQN-----TAPISVATIDFIFKRFYGP 721
Cdd:TIGR00918 844 TQRLVNADGiinpnafyiylsawvsndpvayAASQANIYphppewlHDKNDYDPENlripaAEPLEYAQFPFYLNGLRET 923
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 722 HQWIPAMDESKQVAREVGINGFVTVWSEI-FSLWvtDKLIAqeVQRNVLLALICVMGMTGLLIAELQTCFW----IFLSV 796
Cdd:TIGR00918 924 SQFVEAIEHVRAICNNYEGFGLPSYPSGYpFLFW--EQYMG--LRHWLLLSISVVLACTFLVCALLLLNPWtaglIVLVL 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 797 LLTLLNVCGFMYFWNLTIDIVSCIGLELGIGLCVDYAAHVAHAFINAAcidgsEDRTKRAHIAVRYIGAAVAYGAGSTLL 876
Cdd:TIGR00918 1000 ALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAI-----GDRNRRAVLALEHMFAPVLDGALSTLL 1074
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 877 ALSMMAFSE-SYVFHAFLKIFVLVILFGLWHGLFLLPVILSTIGPR---SLRSHKSPESL 932
Cdd:TIGR00918 1075 GVLMLAGSEfDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEpevSPAEGRSRLPT 1134
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
345-924 |
1.98e-25 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 113.03 E-value: 1.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 345 ILSIGFFLMFFYVLVISSeynwvgcRVYLTIVGLLCVGGAFIVSISVCSLLGISYGPVHTSLPFLLLALGVDDNFLIMAS 424
Cdd:COG1033 223 FFPLALLLILLLLFLFFR-------SLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNR 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 425 WKEVHAQKLNRnkplEKRIALMLGHAGSAIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFFSI 504
Cdd:COG1033 296 YREERRKGLDK----REALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSL 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 505 DARRIENKRNsifpciihenftqkfiNPQEEFSTKLINKIySNIILTKlgKITIVLITIVTASVGLVGILQLQQWFDPTW 584
Cdd:COG1033 372 LPRPKPKTRR----------------LKKPPELGRLLAKL-ARFVLRR--PKVILVVALVLAVVSLYGISRLKVEYDFED 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 585 FIPNHSYLSKYINVHRAEYPdrGYESMILM-----GDFNYTAEFPKLI-NLSEKFANLSTIQSISAwPIDFTKFVLEHFQ 658
Cdd:COG1033 433 YLPEDSPIRQDLDFIEENFG--GSDPLEVVvdtgePDGLKDPEVLKEIdRLQDYLESLPEVGKVLS-LADLVKELNQALN 509
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 659 K-DLRNVILEDTEFQNYLSKFLFSRNGGKYQRNFRFKkslicGQNTAPISV-------ATIDFIFKRFygpHQWIPAMDE 730
Cdd:COG1033 510 EgDPKYYALPESRELLAQLLLLLSSPPGDDLSRFVDE-----DYSAARVTVrlkdldsEEIKALVEEV---RAFLAENFP 581
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 731 SKQVarEVGINGFVTVWSEifslwvtdklIAQEVQRNVLLALICVMGMTGLLiaelqtCFWIFLSVLLTLLNV------- 803
Cdd:COG1033 582 PDGV--EVTLTGSAVLFAA----------INESVIESQIRSLLLALLLIFLL------LLLAFRSLRLGLISLipnllpi 643
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 804 ---CGFMYFWNLTIDIVSCIGLELGIGLCVDYAAHVAHAFINAacIDGSEDRTKRAHIAVRYIGAAVAYGAGSTLLALSM 880
Cdd:COG1033 644 lltFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREE--RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGV 721
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 2088136601 881 MAFSESYVFHAFLKIFVLVILFGLWHGLFLLPVILSTIGPRSLR 924
Cdd:COG1033 722 LLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAK 765
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
792-936 |
1.67e-05 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 48.70 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 792 IFLSVLLTLlnvcGFMYFWNLTIDIVSCIGLELGIGLCVDYAAHVAHAFINAacIDGSEDRTKRAHIAVRYIGAAVAYGA 871
Cdd:COG1033 252 VLLAVIWTL----GLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREE--RRKGLDKREALREALRKLGPPVLLTS 325
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 872 GSTLLALSMMAFSESYVFHAF-----LKIFVLVILFglwhgLFLLPVILStIGPRSLRSHKSPESLEKME 936
Cdd:COG1033 326 LTTAIGFLSLLFSDIPPIRDFgivaaIGVLLAFLTS-----LTLLPALLS-LLPRPKPKTRRLKKPPELG 389
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
335-513 |
2.76e-05 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 47.93 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 335 TFVTMFGnIGILSIGFFLMFFYvlvisseYNWVgcrvyLTIVGLLCVGGAFIVSISVCSLLGISYGPVhTSLPF-LLLAL 413
Cdd:COG1033 606 SQIRSLL-LALLLIFLLLLLAF-------RSLR-----LGLISLIPNLLPILLTFGLMGLLGIPLNIA-TAVVAsIALGI 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 414 GVDDNFLIMASWKEvhaqKLNRNKPLEKRIALMLGHAGSAIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLF 493
Cdd:COG1033 672 GVDYTIHFLSRYRE----ERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLA 747
|
170 180
....*....|....*....|
gi 2088136601 494 QITFYVAFFSIDARRIENKR 513
Cdd:COG1033 748 ALLLLPALLLLLDPRIAKKR 767
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
375-502 |
4.08e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.06 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 375 IVGLLCVGGAFIVSISVCSLLGISYGPVHTSLPFLLLALGVDDNFLIMASWKEvhaqKLNRNKPLEKrIALMLGHAGSAI 454
Cdd:TIGR00921 595 VFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFE----ERKEHGPKEA-ITHTMERTGPGI 669
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2088136601 455 IITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFF 502
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
768-892 |
4.92e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.07 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 768 VLLALICVMGMTGLLIAeLQTCFWIFLSVLLTLlnvcGFMYFWNLTIDIVSCIGLELGIGLCVDYAahvahAFINAACID 847
Cdd:COG4258 650 LLILLLLLLRLRSLRRA-LRVLLPPLLAVLLTL----AILGLLGIPLNLFHLIALLLVLGIGIDYA-----LFFTEGLLD 719
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2088136601 848 GSEDRTKRahiavryigAAVAYGAGSTLLALSMMAFSESYVFHAF 892
Cdd:COG4258 720 KGELARTL---------LSILLAALTTLLGFGLLAFSSTPALRSF 755
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
763-833 |
6.35e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 43.55 E-value: 6.35e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2088136601 763 EVQRNVLLALICVMGMTGLLIAELQTCFWIFLSVLLTLLNVCGFMYFWNLTIDIVSCIGLELGIGLCVDYA 833
Cdd:COG0841 332 EVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
760-918 |
7.86e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 43.29 E-value: 7.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 760 IAQEVQRNVLLALICVMGMTGLLIAELQTCF-----WIFLS---VLLTLLNVCGFMYFWNLTIDIVSCIGLELGIGLCVD 831
Cdd:TIGR00921 183 INYDIEREFGKDMGTTMAISGILVVLVLLLDfkrwwRPLLPlviILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGID 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 832 YAAHVAHAFINAacIDGSEDRTKRAHIAVRYIGAAVAYGAGSTLLALSMMAFSESYVFHAFLKIFVLVILFGLWHGLFLL 911
Cdd:TIGR00921 263 YGIQTLNRYEEE--RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVL 340
|
....*..
gi 2088136601 912 PVILSTI 918
Cdd:TIGR00921 341 PALLQSI 347
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
378-508 |
1.08e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 42.28 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 378 LLCVGGAFIVSISVCSLL-GISYGPVHT-SLPF---LLLALGVDDNFLIMASWKEVHAQKLNRnkplEKRIALMLGHAGS 452
Cdd:pfam03176 173 LLTVGLSLGAAQGLVAILaHILGIGLSTfALNLlvvLLIAVGTDYALFLVSRYREELRAGEDR----EEAVIRAVRGTGK 248
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2088136601 453 AIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARR 508
Cdd:pfam03176 249 VVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW 304
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
317-587 |
1.38e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.52 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 317 VNNTLAIWYEAGRSFGDvTFVTMFGNIGILSIGFFLMFFYvlvisseynwvgcRVYLTIVGLLCVGGAFIVSISVCSLLG 396
Cdd:TIGR00921 177 VTGSPAINYDIEREFGK-DMGTTMAISGILVVLVLLLDFK-------------RWWRPLLPLVIILFGVAWVLGIMGWLG 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 397 ISYGPVHTSLPFLLLALGVDDNFLIMASWKEvhaqKLNRNKPLEKRIALMLGHAGSAIIITSLTDVVAFIIGASTILPSL 476
Cdd:TIGR00921 243 IPLYATTLLAVPMLIGVGIDYGIQTLNRYEE----ERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMV 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 477 QSYCIYAAFGVLLTFLFQITFYVA-FFSIDARRIENKRnsifpciihENFTQKFINPQEEFSTKLINKIysniilTKLGK 555
Cdd:TIGR00921 319 SEFGLGLVAGLITAYLLTLLVLPAlLQSIDIGREKVKK---------EIIAIGGKSSEIEEELSKVLSI------TVRHP 383
|
250 260 270
....*....|....*....|....*....|..
gi 2088136601 556 ITIVLITIVTASVGLVGILQLQQWFDPTWFIP 587
Cdd:TIGR00921 384 VPALVAALIITGLGLYGAAGIKPEVNIEKFIP 415
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
794-924 |
2.62e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 41.67 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 794 LSVLLTLLNVCGFMYFWNLTIDI---VSCIGLELGIGLCVDYAAhvahaFINA---ACIDGSEDRTKRAHIAVRYIGAAV 867
Cdd:COG2409 201 LTAGLAVGVALGLLALLAAFTDVssfAPNLLTMLGLGVGIDYAL-----FLVSryrEELRAGEDREEAVARAVATAGRAV 275
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2088136601 868 AYGAGSTLLALSMMAFSESYVFHAFLKIFVLVILFGLWHGLFLLPVILSTIGPRSLR 924
Cdd:COG2409 276 LFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRVFW 332
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
368-504 |
2.65e-03 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 41.77 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 368 GCRVYLTIVGLLCVGGAFIVSISVCSLLGISYGPVHTSLPFLLLALGvddnfLIMASWKEVHAQKLNRNKPLEKRIALML 447
Cdd:TIGR00920 87 GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLNEALPFFLLLID-----LSKASALAKFALSSNSQDEVRDNIARGM 161
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2088136601 448 GHAGSAIIITSLtdVVAFIIGASTI--LPSLQSYCIYAAFGVLLTFLFQITFYVAFFSI 504
Cdd:TIGR00920 162 AILGPTITLDTV--VETLVIGVGTMsgVRRLEVLCCFGCMSVLANYFVFMTFFPACLSL 218
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
375-634 |
3.99e-03 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 41.11 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 375 IVGLLCVGGAFIVSISVCSLLGIS--YGPVHTSLPF---LLLALGVDDNFLIMASWKEvhaqKLNRNKPLEKRIALMLGH 449
Cdd:TIGR00833 201 LVPLVSVGFSVVVAQGIVSLLGIPglIGVNAQTTVLltaLVIGAGTDYAVFLTGRYHE----ERRKGESLEEAAAEALRG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 450 AGSAIIITSLTDVVAFIIGASTILPSLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARRienkrnsifpciihenftqKF 529
Cdd:TIGR00833 277 TGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE-------------------GL 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 530 INPQEefstklinKIYSNIILTKLGKI------TIVLITIVTASVGLVGILQLQQWFDPTWFIPNHSYLSKYINVHRAEY 603
Cdd:TIGR00833 338 MKPGR--------KSKIRFIWRRLGTAvvrrpwPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQGYEAADRHF 409
|
250 260 270
....*....|....*....|....*....|.
gi 2088136601 604 PDRGYESMILMGDFNYTAEFPKLINLSEKFA 634
Cdd:TIGR00833 410 PGNSMDPMVVMIKSDHDVRNPALLADIDRFE 440
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
378-509 |
7.34e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 40.13 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 378 LLCVGGAFIVSISVCSLLGiSYGPVHTSLPFLL----LALGVDDNFLIMASWKEvhaqKLNRNKPLEKRIALMLGHAGSA 453
Cdd:COG2409 200 LLTAGLAVGVALGLLALLA-AFTDVSSFAPNLLtmlgLGVGIDYALFLVSRYRE----ELRAGEDREEAVARAVATAGRA 274
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2088136601 454 IIITSLTDVVA----FIIGastiLPSLQSYCIYAAFGVLLTFLFQITFYVAFFSIDARRI 509
Cdd:COG2409 275 VLFSGLTVAIAllglLLAG----LPFLRSMGPAAAIGVAVAVLAALTLLPALLALLGRRV 330
|
|
| |
