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Conserved domains on  [gi|2086939343|gb|KAG9351873|]
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hypothetical protein JZ751_023124 [Albula glossodonta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 259-420 5.12e-99

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


:

Pssm-ID: 293942  Cd Length: 177  Bit Score: 311.44  E-value: 5.12e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  259 DTCDGYPLTIEGFAYLWSGARATYGVSSGRVCYEMKINEEISVKHLPTSEPDPHVVRVGWSLDSCSTQLGEEPFSYGYGG 338
Cdd:cd12884     17 DRYSASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTENLPVKHLPTEETDPHVVRVGWSVDSSSLQLGEEEFSYGYGS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  339 TGKKSSNCKFEDYGEKFGENDVLGCFIDFEsSEQVEIAFSKNGKWLGPCYQVNREELEGRPLIPHVLVKNCAIEFNFGQK 418
Cdd:cd12884     97 TGKKSTNCKFEDYGEPFGENDVIGCYLDFE-SEPVEISFSKNGKDLGVAFKISKEELGGKALFPHVLTKNCAVEVNFGQK 175


                   ..
gi 2086939343  419 EE 420
Cdd:cd12884    176 EE 177
DUF2465 super family cl10924
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 894-1149 7.45e-59

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


The actual alignment was detected with superfamily member pfam10239:

Pssm-ID: 463016  Cd Length: 302  Bit Score: 204.79  E-value: 7.45e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  894 ELRALLEELHCPYTALATETLTPELLNTAT-----EFLVGELQAARILQYRKHhpedtlRQDNTEREKREGEdrgvdleg 968
Cdd:pfam10239   51 ELSGFLKELGCPYSALTSGPVTERLKSKEDrlkllEFLSSELQAARILLSKKP------TEPPNELTKKESP-------- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  969 egrggdgavwdkegeadIREEIVQLFQVLSLD---PSSQLSDAYTEVESRITLL----PGGTVAEPLLKTTLNSEQWRKL 1041
Cdd:pfam10239  117 -----------------TAQELKAICITLGLPkppANITASQLFSKIETKVNELlkklPPNHVGKPLLKKPLTPEQWEKL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343 1042 EQITLALAKDYECRRDMMTKRFQVTLQSFEWGEKGPERSAALSSV-QP----LSALffgSRVSLSLLLAAREDQSRVLP- 1115
Cdd:pfam10239  180 EKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKVKEDEIARVyQPkrhsLDPE---SDVSLAHLLAAREDLAIIEKt 256

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2086939343 1116 ----VRAGQSTAIHKVLMGSVPDRGGRPGEIEPP---MPVW 1149
Cdd:pfam10239  257 ssgsVRKNTKCAINKVLIGRVPDRGGRPSEIEPPppeMPSW 297
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 456-551 7.97e-14

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 69.65  E-value: 7.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  456 LMMVGLPASGKTTWAMKHAVENPekkYNILGTNSIMEKMKdapcclwgwgVMGLRRQRNYAGRWDVliqqATQCLNRLIQ 535
Cdd:pfam13671    2 ILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLF----------GEGRPSISYYTDATDR----TYERLHELAR 64

                           90
                   ....*....|....*.
gi 2086939343  536 IAARKRRNYILDqATF 551
Cdd:pfam13671   65 IALRAGRPVILD-ATN 79
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
6-40 9.36e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


:

Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.58  E-value: 9.36e-12
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2086939343     6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAAL 40
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 259-420 5.12e-99

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 311.44  E-value: 5.12e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  259 DTCDGYPLTIEGFAYLWSGARATYGVSSGRVCYEMKINEEISVKHLPTSEPDPHVVRVGWSLDSCSTQLGEEPFSYGYGG 338
Cdd:cd12884     17 DRYSASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTENLPVKHLPTEETDPHVVRVGWSVDSSSLQLGEEEFSYGYGS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  339 TGKKSSNCKFEDYGEKFGENDVLGCFIDFEsSEQVEIAFSKNGKWLGPCYQVNREELEGRPLIPHVLVKNCAIEFNFGQK 418
Cdd:cd12884     97 TGKKSTNCKFEDYGEPFGENDVIGCYLDFE-SEPVEISFSKNGKDLGVAFKISKEELGGKALFPHVLTKNCAVEVNFGQK 175


                   ..
gi 2086939343  419 EE 420
Cdd:cd12884    176 EE 177
DUF2465 pfam10239
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 894-1149 7.45e-59

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


Pssm-ID: 463016  Cd Length: 302  Bit Score: 204.79  E-value: 7.45e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  894 ELRALLEELHCPYTALATETLTPELLNTAT-----EFLVGELQAARILQYRKHhpedtlRQDNTEREKREGEdrgvdleg 968
Cdd:pfam10239   51 ELSGFLKELGCPYSALTSGPVTERLKSKEDrlkllEFLSSELQAARILLSKKP------TEPPNELTKKESP-------- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  969 egrggdgavwdkegeadIREEIVQLFQVLSLD---PSSQLSDAYTEVESRITLL----PGGTVAEPLLKTTLNSEQWRKL 1041
Cdd:pfam10239  117 -----------------TAQELKAICITLGLPkppANITASQLFSKIETKVNELlkklPPNHVGKPLLKKPLTPEQWEKL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343 1042 EQITLALAKDYECRRDMMTKRFQVTLQSFEWGEKGPERSAALSSV-QP----LSALffgSRVSLSLLLAAREDQSRVLP- 1115
Cdd:pfam10239  180 EKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKVKEDEIARVyQPkrhsLDPE---SDVSLAHLLAAREDLAIIEKt 256

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2086939343 1116 ----VRAGQSTAIHKVLMGSVPDRGGRPGEIEPP---MPVW 1149
Cdd:pfam10239  257 ssgsVRKNTKCAINKVLIGRVPDRGGRPSEIEPPppeMPSW 297
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 286-417 2.12e-23

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 96.59  E-value: 2.12e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343   286 SGRVCYEMKINeeisvkhlptsepDPHVVRVGWSLDSCS----TQLGEEPFSYGYGGT-GKKSSNCKFEDYGEKFGE-ND 359
Cdd:smart00449    1 SGRHYFEVEIG-------------DGGHWRVGVATKSVPrgyfALLGEDKGSWGYDGDgGKKYHNSTGPEYGLPLQEpGD 67

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343   360 VLGCFIDFESSeqvEIAFSKNGKWLGPCYQvnrEELE-GRPLIPHVLVKN-CAIEFNFGQ 417
Cdd:smart00449   68 VIGCFLDLEAG---TISFYKNGKYLHGLAF---FDVKfSGPLYPAFSLGSgNSVRLNFGP 121
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 308-417 3.82e-21

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 90.09  E-value: 3.82e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  308 EPDPHVVRVGWSLDSCSTQ----LGEEPFSYGYGG-TGKKSSNCKFEDYGE-KFGENDVLGCFIDFESSeqvEIAFSKNG 381
Cdd:pfam00622   10 GQDGGGWRVGWATKSVPRKgerfLGDESGSWGYDGwTGKKYWASTSPLTGLpLFEPGDVIGCFLDYEAG---TISFTKNG 86

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2086939343  382 KWLGPCYQVNREELegrPLIPHV-LVKNCAIEFNFGQ 417
Cdd:pfam00622   87 KSLGYAFRDVPFAG---PLFPAVsLGAGEGLKFNFGL 120
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 456-551 7.97e-14

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 69.65  E-value: 7.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  456 LMMVGLPASGKTTWAMKHAVENPekkYNILGTNSIMEKMKdapcclwgwgVMGLRRQRNYAGRWDVliqqATQCLNRLIQ 535
Cdd:pfam13671    2 ILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLF----------GEGRPSISYYTDATDR----TYERLHELAR 64

                           90
                   ....*....|....*.
gi 2086939343  536 IAARKRRNYILDqATF 551
Cdd:pfam13671   65 IALRAGRPVILD-ATN 79
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
6-40 9.36e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.58  E-value: 9.36e-12
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2086939343     6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAAL 40
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 6-40 3.64e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.57  E-value: 3.64e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2086939343    6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAAL 40
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 8-44 4.52e-05

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 47.53  E-value: 4.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2086939343    8 KLKVNELKEELQRRGLDTRGLKADLVDRLQAALEAEA 44
Cdd:PLN03124     4 KLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDA 40
COG4639 COG4639
Predicted kinase [General function prediction only];
453-550 2.07e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 42.89  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  453 CEILMMVGLPASGKTTWAMKHAVENPekkynILGTNSIMEKMKDAPcclwgwgvmglRRQRNYAGRWDVLIQQATQCLnr 532
Cdd:COG4639      2 LSLVVLIGLPGSGKSTFARRLFAPTE-----VVSSDDIRALLGGDE-----------NDQSAWGDVFQLAHEIARARL-- 63

                           90
                   ....*....|....*...
gi 2086939343  533 liqiaaRKRRNYILDqAT 550
Cdd:COG4639     64 ------RAGRLTVVD-AT 74
pseT PHA02530
polynucleotide kinase; Provisional
 453-484 6.53e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 43.09  E-value: 6.53e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2086939343  453 CEILMMVGLPASGKTTWAMKHAVENPeKKYNI 484
Cdd:PHA02530     2 MKIILTVGVPGSGKSTWAREFAAKNP-KAVNV 32
 
Name Accession Description Interval E-value
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 259-420 5.12e-99

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 311.44  E-value: 5.12e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  259 DTCDGYPLTIEGFAYLWSGARATYGVSSGRVCYEMKINEEISVKHLPTSEPDPHVVRVGWSLDSCSTQLGEEPFSYGYGG 338
Cdd:cd12884     17 DRYSASPLTDEGFAYLWAGARATYGVTKGKVCFEVKVTENLPVKHLPTEETDPHVVRVGWSVDSSSLQLGEEEFSYGYGS 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  339 TGKKSSNCKFEDYGEKFGENDVLGCFIDFEsSEQVEIAFSKNGKWLGPCYQVNREELEGRPLIPHVLVKNCAIEFNFGQK 418
Cdd:cd12884     97 TGKKSTNCKFEDYGEPFGENDVIGCYLDFE-SEPVEISFSKNGKDLGVAFKISKEELGGKALFPHVLTKNCAVEVNFGQK 175


                   ..
gi 2086939343  419 EE 420
Cdd:cd12884    176 EE 177
DUF2465 pfam10239
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 894-1149 7.45e-59

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


Pssm-ID: 463016  Cd Length: 302  Bit Score: 204.79  E-value: 7.45e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  894 ELRALLEELHCPYTALATETLTPELLNTAT-----EFLVGELQAARILQYRKHhpedtlRQDNTEREKREGEdrgvdleg 968
Cdd:pfam10239   51 ELSGFLKELGCPYSALTSGPVTERLKSKEDrlkllEFLSSELQAARILLSKKP------TEPPNELTKKESP-------- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  969 egrggdgavwdkegeadIREEIVQLFQVLSLD---PSSQLSDAYTEVESRITLL----PGGTVAEPLLKTTLNSEQWRKL 1041
Cdd:pfam10239  117 -----------------TAQELKAICITLGLPkppANITASQLFSKIETKVNELlkklPPNHVGKPLLKKPLTPEQWEKL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343 1042 EQITLALAKDYECRRDMMTKRFQVTLQSFEWGEKGPERSAALSSV-QP----LSALffgSRVSLSLLLAAREDQSRVLP- 1115
Cdd:pfam10239  180 EKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKVKEDEIARVyQPkrhsLDPE---SDVSLAHLLAAREDLAIIEKt 256

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2086939343 1116 ----VRAGQSTAIHKVLMGSVPDRGGRPGEIEPP---MPVW 1149
Cdd:pfam10239  257 ssgsVRKNTKCAINKVLIGRVPDRGGRPSEIEPPppeMPSW 297
SPRY_DDX1 cd12873
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ...
 275-418 4.37e-43

SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay.


Pssm-ID: 293933  Cd Length: 155  Bit Score: 153.88  E-value: 4.37e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  275 WSGARATYGVS-SGRVCYEMKINEEisvkhlptsepdpHVVRVGWSLDSCSTQLGEEPFSYGYGGTGKKSSNCKFEDYGE 353
Cdd:cd12873     27 WQGCRATKGVKgKGKYYYEVTVTDE-------------GLCRVGWSTEDASLDLGTDKFGFGYGGTGKKSHGRQFDDYGE 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2086939343  354 KFGENDVLGCFIDFESSeqvEIAFSKNGKWLGPCYQVNrEELEGRPLIPHVLVKNCAIEFNFGQK 418
Cdd:cd12873     94 PFGLGDVIGCYLDLDNG---TISFSKNGKDLGKAFDIP-PHLRNSALFPAVCLKNAEVEFNFGDK 154
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 286-417 2.12e-23

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 96.59  E-value: 2.12e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343   286 SGRVCYEMKINeeisvkhlptsepDPHVVRVGWSLDSCS----TQLGEEPFSYGYGGT-GKKSSNCKFEDYGEKFGE-ND 359
Cdd:smart00449    1 SGRHYFEVEIG-------------DGGHWRVGVATKSVPrgyfALLGEDKGSWGYDGDgGKKYHNSTGPEYGLPLQEpGD 67

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343   360 VLGCFIDFESSeqvEIAFSKNGKWLGPCYQvnrEELE-GRPLIPHVLVKN-CAIEFNFGQ 417
Cdd:smart00449   68 VIGCFLDLEAG---TISFYKNGKYLHGLAF---FDVKfSGPLYPAFSLGSgNSVRLNFGP 121
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 275-423 3.78e-21

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 91.04  E-value: 3.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  275 WSGARATYGVSSGRVCYEMKINEeisvkhlPTSEPDPHvVRVGWSLDSCSTQ--LGEEPFSYGYGG-TGKKSSNCKFEDY 351
Cdd:cd12872     16 YRMARANHGVREGKWYFEVKILE-------GGGTETGH-VRVGWSRREASLQapVGYDKYSYAIRDkDGSKFHQSRGKPY 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2086939343  352 GEK-FGENDVLGCFIDFEsseqvEIAFSKNGKWLGPCYqvnrEELEGR----PLIPhvLVKNCAIEFNFGqkeePYF 423
Cdd:cd12872     88 GEPgFKEGDVIGFLITLP-----KIEFFKNGKSQGVAF----EDIYGTggyyPAVS--LYKGATVTINFG----PDF 149
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 308-417 3.82e-21

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 90.09  E-value: 3.82e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  308 EPDPHVVRVGWSLDSCSTQ----LGEEPFSYGYGG-TGKKSSNCKFEDYGE-KFGENDVLGCFIDFESSeqvEIAFSKNG 381
Cdd:pfam00622   10 GQDGGGWRVGWATKSVPRKgerfLGDESGSWGYDGwTGKKYWASTSPLTGLpLFEPGDVIGCFLDYEAG---TISFTKNG 86

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2086939343  382 KWLGPCYQVNREELegrPLIPHV-LVKNCAIEFNFGQ 417
Cdd:pfam00622   87 KSLGYAFRDVPFAG---PLFPAVsLGAGEGLKFNFGL 120
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 287-414 7.20e-17

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 77.86  E-value: 7.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  287 GRVCYEMKINEEISvkhlptsepdpHVVRVGWSLDSCSTQ----LGEEPFSYGYGGTGKKS-SNCKFEDYGEKFGENDVL 361
Cdd:cd11709      1 GKWYWEVRVDSGNG-----------GLIQVGWATKSFSLDgeggVGDDEESWGYDGSRLRKgHGGSSGPGGRPWKSGDVV 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2086939343  362 GCFIDFessEQVEIAFSKNGKWLGPCYQVnrEELEGRPLIPHV-LVKNCAIEFN 414
Cdd:cd11709     70 GCLLDL---DEGTLSFSLNGKDLGVAFTN--LFLKGGGLYPAVsLGSGQGVTIN 118
SPRY_RanBP_like cd12885
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ...
 298-416 1.54e-14

SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate.


Pssm-ID: 293943  Cd Length: 132  Bit Score: 71.54  E-value: 1.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  298 EISVKHLPTSepdpHVVRVGWSLDSCST--QLGEEPFSYGY-GGTGKKSSNCKF-EDYGEKFGENDVLGCFIDFESSeqv 373
Cdd:cd12885     19 EVTILDLGEK----GIVSIGFCTSGFPLnrMPGWEDGSYGYhGDDGRVYLGGGEgENYGPPFGTGDVVGCGINFKTG--- 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2086939343  374 EIAFSKNGKWLGP-CYQVNREELegRPLIpHVLVKNCAIEFNFG 416
Cdd:cd12885     92 EVFFTKNGELLGTaFENVVKGRL--YPTV-GLGSPGVKVRVNFG 132
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 456-551 7.97e-14

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 69.65  E-value: 7.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  456 LMMVGLPASGKTTWAMKHAVENPekkYNILGTNSIMEKMKdapcclwgwgVMGLRRQRNYAGRWDVliqqATQCLNRLIQ 535
Cdd:pfam13671    2 ILLVGLPGSGKSTLARRLLEELG---AVRLSSDDERKRLF----------GEGRPSISYYTDATDR----TYERLHELAR 64

                           90
                   ....*....|....*.
gi 2086939343  536 IAARKRRNYILDqATF 551
Cdd:pfam13671   65 IALRAGRPVILD-ATN 79
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
6-40 9.36e-12

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 60.58  E-value: 9.36e-12
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2086939343     6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAAL 40
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 6-40 3.64e-11

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 58.57  E-value: 3.64e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2086939343    6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAAL 40
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
SPRY_RNF123 cd12882
SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the ...
 278-416 4.09e-10

SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the N-terminus of RING finger protein 123 domain (also known as E3 ubiquitin-protein ligase RNF123). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1).


Pssm-ID: 293940  Cd Length: 128  Bit Score: 58.88  E-value: 4.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  278 ARATYGVSSGRVCYEMkineeisvkHLPTSEpdphVVRVGWSLDSC----STQLGEEPFSYGYGGTGKKSSNCKFEDYGE 353
Cdd:cd12882      2 IRANACVYKGKWMYEV---------TLGTKG----IMQIGWATISCrftqEEGVGDTRDSYAYDGNRVRKWNVSTQKYGE 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086939343  354 KFGENDVLGCFIDFessEQVEIAFSKNGKWLGPCYQvNREELEGRPLIPHV-LVKNCAIEFNFG 416
Cdd:cd12882     69 PWVAGDVIGCCIDL---DKGTISFYRNGRSLGVAFD-NVRRGPGLAYFPAVsLSFGERLELNFG 128
SPRY_RanBP9_10 cd12909
SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding ...
 328-417 8.74e-07

SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding protein (RBP or RanBPM) 9 and 10, and similar proteins. RanBP9 (also known as RanBPM), a binding partner of Ran, is a small Ras-like GTPase that exerts multiple functions via interactions with various proteins. RanBP9 and RanBP10 also act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. SPRY domain of RanBPM forms a complex with CD39, a prototypic member of the NTPDase family, thus down-regulating activity substantially. RanBP10 enhances the transcriptional activity of AR in a ligand-dependent manner and exhibits a protein expression pattern different from RanBPM in various cell lines. RanBP10 is highly expressed in AR-positive prostate cancer LNCaP cells, while RanBPM is abundant in WI-38 and MCF-7 cells.


Pssm-ID: 293966  Cd Length: 144  Bit Score: 49.44  E-value: 8.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  328 GEEPFSYGY----------GGTGKKssnckfedYGEKFGENDVLGCFIDFESSeqvEIAFSKNGKWLGPCYqvnrEELEG 397
Cdd:cd12909     58 GWEPHSWGYhgddghsfcsSGTGKP--------YGPTFTTGDVIGCGINFRDN---TAFYTKNGVNLGIAF----RDIKK 122

                           90       100
                   ....*....|....*....|..
gi 2086939343  398 RPLIPHVLVK--NCAIEFNFGQ 417
Cdd:cd12909    123 GNLYPTVGLRtpGEHVEANFGQ 144
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 278-384 8.93e-07

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 49.22  E-value: 8.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  278 ARATYGVSSGRVCYEMKINeeisvkhlptsepDPHVVRVGWSLDSC--STQLGEEPFSYGYGGTGKKSSNCKFEDYGEKF 355
Cdd:cd12878      5 AEKTYAVTSGKWYFEFEVL-------------TSGYMRVGWARPGFrpDLELGSDDLSYAFDGFLARKWHQGSESFGKQW 71

                           90       100
                   ....*....|....*....|....*....
gi 2086939343  356 GENDVLGCFIDFESSeqvEIAFSKNGKWL 384
Cdd:cd12878     72 QPGDVVGCMLDLVDR---TISFTLNGELL 97
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 8-44 4.52e-05

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 47.53  E-value: 4.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2086939343    8 KLKVNELKEELQRRGLDTRGLKADLVDRLQAALEAEA 44
Cdd:PLN03124     4 KLKVDELRAALAKRGLDTTGLKAALVRRLDDAIAEDA 40
COG4639 COG4639
Predicted kinase [General function prediction only];
453-550 2.07e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 42.89  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  453 CEILMMVGLPASGKTTWAMKHAVENPekkynILGTNSIMEKMKDAPcclwgwgvmglRRQRNYAGRWDVLIQQATQCLnr 532
Cdd:COG4639      2 LSLVVLIGLPGSGKSTFARRLFAPTE-----VVSSDDIRALLGGDE-----------NDQSAWGDVFQLAHEIARARL-- 63

                           90
                   ....*....|....*...
gi 2086939343  533 liqiaaRKRRNYILDqAT 550
Cdd:COG4639     64 ------RAGRLTVVD-AT 74
PLN03124 PLN03124
poly [ADP-ribose] polymerase; Provisional
 6-67 3.47e-04

poly [ADP-ribose] polymerase; Provisional


Pssm-ID: 215591 [Multi-domain]  Cd Length: 643  Bit Score: 44.83  E-value: 3.47e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086939343    6 VKKLKVNELKEELQRRGLDTRGLKADLVDRLQAALEAEATGEGGGPPVAIGEGYGIGEEAGE 67
Cdd:PLN03124    79 VKGMTVRELREAASERGLATTGRKKDLLERLCAALESDVKVGSANGTGEDEKEKGGDEEREK 140
SPRY_RING cd12883
SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY ...
 311-416 5.38e-04

SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY domain is found at the N-terminus of RING finger domains which are present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RING-finger domain is a type of Zn-finger that binds two Zn atoms and is identified in proteins with a wide range of functions such as viral replication, signal transduction, and development.


Pssm-ID: 293941  Cd Length: 121  Bit Score: 41.18  E-value: 5.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  311 PHVVRVGWSLDSCSTQ------LGEEPFSYGYGGTGK------KSSNCKFEdygeKFGENDVLGCFIDFESSeqvEIAFS 378
Cdd:cd12883     12 SGVMQIGWATKDSKFLnhegygIGDDEYSCAYDGCRQliwynaKSKPHTHP----RWKPGDVLGCLLDLNKK---QMIFS 84

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2086939343  379 KNGKWLGPCYQVNREELEG-RPLIPHVLVKNCaiEFNFG 416
Cdd:cd12883     85 LNGNRLPPERQVFTSAKSGfFAAASFMSFQQC--EFNFG 121
pseT PHA02530
polynucleotide kinase; Provisional
 453-484 6.53e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 43.09  E-value: 6.53e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2086939343  453 CEILMMVGLPASGKTTWAMKHAVENPeKKYNI 484
Cdd:PHA02530     2 MKIILTVGVPGSGKSTWAREFAAKNP-KAVNV 32
SPRY_SSH4_like cd12910
SPRY domain in SSH4 and similar proteins; This family includes SPRY domain in SSH4 (suppressor ...
 332-417 8.44e-04

SPRY domain in SSH4 and similar proteins; This family includes SPRY domain in SSH4 (suppressor of SHR3 null mutation protein 4) and similar proteins. SSH4 is a component of the endosome-vacuole trafficking pathway that regulates nutrient transport and may be involved in processes determining whether plasma membrane proteins are degraded or routed to the plasma membrane. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. In yeast, SSH4 and the homologous protein EAR1 (endosomal adapter of RSP5) recruit Rsp5p, an essential ubiquitin ligase of the Nedd4 family, and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes.


Pssm-ID: 293967  Cd Length: 192  Bit Score: 41.96  E-value: 8.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  332 FSYGY-GGTGKKSSNCKF--EDYGEKFGENDVLGCFIDFESseqVEIAFSKNGKWLGP--------CYQVNREELEGR-P 399
Cdd:cd12910     94 GSLAVhSDDGHRYINDPFggKDFTPPFREGDTIGIGYRFSS---GTIFFTRNGKRLGGwdlgeeldAEDDGVTGLEGFhD 170

                           90       100
                   ....*....|....*....|
gi 2086939343  400 LIPHVLVKN--CAIEFNFGQ 417
Cdd:cd12910    171 LYAAIGVFGgeCEVHVNPGQ 190
SPRY_like cd12886
SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in ...
 333-416 4.66e-03

SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in bacterial and are mostly uncharacterized. SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 eukaryotic protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L).


Pssm-ID: 293944  Cd Length: 129  Bit Score: 38.64  E-value: 4.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086939343  333 SYGYGGT----GKKSSNCKFEDYGEKFGENDVLGCFIDFESseqVEIAFSKNGKWL--GPCYQVNREELEGRPLIPHVLV 406
Cdd:cd12886     40 SIGYSLGvysgNKLSNGSSVATYGAGFTAGDVIGVALDLDA---GKIWFYKNGVWQggGDPAPGTNPAFAGTAMYPAVTG 116

                           90
                   ....*....|...
gi 2086939343  407 KNCAI---EFNFG 416
Cdd:cd12886    117 GSSTGgsfTANFG 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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