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Conserved domains on  [gi|2084127551|ref|WP_221231526|]
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sensor histidine kinase [Salinibacter ruber]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
1-344 1.02e-80

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 250.56  E-value: 1.02e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551   1 MSRRHAYWICQLGGWTGYSVMRLTLYSFFQTITWKWGVSYVVFIAAGVLYTHLYRHLAKRREWTQMSLGQLAPRVVGATL 80
Cdd:COG3275     3 ALLLLLLLLLLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  81 TVALLLHLTMDGVGRYVLERDFYEEVQSEIGMLLASVVNMWILLMLWSLIYFGVHYFWSYRQAEVDKWKLEAQAETARLK 160
Cdd:COG3275    83 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 161 ALKLQLNPHFFFNSLNSVRALIAEDPDGAQRMVTRLARLLRSTLQADDMKTVPLEEELSTVRTYLKLEKVRFEDRLRHRI 240
Cdd:COG3275   163 ALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 241 EVDDEARSHPVPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPGTL-----DTEEGGTGLDNARERLR 315
Cdd:COG3275   243 DIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGiqpkkKKKGSGIGLKNVRERLE 322

                         330       340
                  ....*....|....*....|....*....
gi 2084127551 316 LLFGTEASLTVENTDAETVSATAVLPVRA 344
Cdd:COG3275   323 LLYGDKYSLEIESTDGGGTKVTLKIPLKK 351
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
1-344 1.02e-80

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 250.56  E-value: 1.02e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551   1 MSRRHAYWICQLGGWTGYSVMRLTLYSFFQTITWKWGVSYVVFIAAGVLYTHLYRHLAKRREWTQMSLGQLAPRVVGATL 80
Cdd:COG3275     3 ALLLLLLLLLLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  81 TVALLLHLTMDGVGRYVLERDFYEEVQSEIGMLLASVVNMWILLMLWSLIYFGVHYFWSYRQAEVDKWKLEAQAETARLK 160
Cdd:COG3275    83 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 161 ALKLQLNPHFFFNSLNSVRALIAEDPDGAQRMVTRLARLLRSTLQADDMKTVPLEEELSTVRTYLKLEKVRFEDRLRHRI 240
Cdd:COG3275   163 ALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 241 EVDDEARSHPVPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPGTL-----DTEEGGTGLDNARERLR 315
Cdd:COG3275   243 DIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGiqpkkKKKGSGIGLKNVRERLE 322

                         330       340
                  ....*....|....*....|....*....
gi 2084127551 316 LLFGTEASLTVENTDAETVSATAVLPVRA 344
Cdd:COG3275   323 LLYGDKYSLEIESTDGGGTKVTLKIPLKK 351
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 157-236 3.70e-34

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 120.62  E-value: 3.70e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 157 ARLKALKLQLNPHFFFNSLNSVRALIAEDPDGAQRMVTRLARLLRSTLQaDDMKTVPLEEELSTVRTYLKLEKVRFEDRL 236
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-341 1.04e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 60.92  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 251 VPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPG------------TLDTEEGGTGLDNARERLRLLF 318
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGrgidpkvlnilgKKPKEGNGIGLYNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 2084127551 319 GTEASLTVENTDAETVSATAVLP 341
Cdd:cd16924    81 GEDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 255-343 9.52e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 41.10  E-value: 9.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  255 LVQTLVENGIKHgvacCQEGGVITVRGRVVDGALHIRVTNPG-------------------TLDTEEGGT--GLDNARER 313
Cdd:smart00387   9 VLSNLLDNAIKY----TPEGGRITVTLERDGDHVEITVEDNGpgippedlekifepffrtdKRSRKIGGTglGLSIVKKL 84

                           90       100       110
                   ....*....|....*....|....*....|
gi 2084127551  314 LRLLFGTeasLTVENTDAETVSATAVLPVR 343
Cdd:smart00387  85 VELHGGE---ISVESEPGGGTTFTITLPLE 111
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
1-344 1.02e-80

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 250.56  E-value: 1.02e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551   1 MSRRHAYWICQLGGWTGYSVMRLTLYSFFQTITWKWGVSYVVFIAAGVLYTHLYRHLAKRREWTQMSLGQLAPRVVGATL 80
Cdd:COG3275     3 ALLLLLLLLLLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  81 TVALLLHLTMDGVGRYVLERDFYEEVQSEIGMLLASVVNMWILLMLWSLIYFGVHYFWSYRQAEVDKWKLEAQAETARLK 160
Cdd:COG3275    83 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 161 ALKLQLNPHFFFNSLNSVRALIAEDPDGAQRMVTRLARLLRSTLQADDMKTVPLEEELSTVRTYLKLEKVRFEDRLRHRI 240
Cdd:COG3275   163 ALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 241 EVDDEARSHPVPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPGTL-----DTEEGGTGLDNARERLR 315
Cdd:COG3275   243 DIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGiqpkkKKKGSGIGLKNVRERLE 322

                         330       340
                  ....*....|....*....|....*....
gi 2084127551 316 LLFGTEASLTVENTDAETVSATAVLPVRA 344
Cdd:COG3275   323 LLYGDKYSLEIESTDGGGTKVTLKIPLKK 351
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
9-343 1.56e-66

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 216.81  E-value: 1.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551   9 ICQLGGWTGYSVMRLT--LYSFFQTITWKWGVSYVVFIAAGVLYTHLYRHLAKRrewtqmslgqlaprvvgatltvALLL 86
Cdd:COG2972   131 LLSLLGWTLVSLIPKSelFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRP----------------------IKRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  87 HLTMDGVGRYVLERdFYEEVQSEIGMLLASVVNMWIllmlwsliyfgvhyfwSYRQAEVDKWKLEAQAETARLKALKLQL 166
Cdd:COG2972   189 KKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVE----------------RIKELIEEVYELELEKKEAELKALQAQI 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 167 NPHFFFNSLNSVRALI-AEDPDGAQRMVTRLARLLRSTLQADDmKTVPLEEELSTVRTYLKLEKVRFEDRLRHRIEVDDE 245
Cdd:COG2972   252 NPHFLFNTLNSIRWLAeLEDPEEAEEMLEALSKLLRYSLSKGD-ELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEE 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 246 ARSHPVPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPG---------------TLDTEEGGTGLDNA 310
Cdd:COG2972   331 LLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGvgmpeekleklleelSSKGEGRGIGLRNV 410

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2084127551 311 RERLRLLFGTEASLTVENTDAETVSATAVLPVR 343
Cdd:COG2972   411 RERLKLYYGEEYGLEIESEPGEGTTVTIRIPLE 443
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 157-236 3.70e-34

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 120.62  E-value: 3.70e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 157 ARLKALKLQLNPHFFFNSLNSVRALIAEDPDGAQRMVTRLARLLRSTLQaDDMKTVPLEEELSTVRTYLKLEKVRFEDRL 236
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-341 1.04e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 60.92  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 251 VPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPG------------TLDTEEGGTGLDNARERLRLLF 318
Cdd:cd16924     1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGrgidpkvlnilgKKPKEGNGIGLYNVHQRLILLF 80

                          90       100
                  ....*....|....*....|...
gi 2084127551 319 GTEASLTVENTDAETVSATAVLP 341
Cdd:cd16924    81 GEDYGIHIASEPDKGTRITFTIP 103
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-341 3.77e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 59.37  E-value: 3.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 251 VPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPGTL---DT-------EEGGTGLDNARERLRLLFGT 320
Cdd:cd16956     1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGmdpDTlarilirSSNGLGLNLVDKRLRQAFGN 80

                          90       100
                  ....*....|....*....|.
gi 2084127551 321 EASLTVENTDAETVSATAVLP 341
Cdd:cd16956    81 DYGLDIECAPGEGTRITIRLP 101
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-341 9.32e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 58.21  E-value: 9.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 251 VPFMLVQTLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVTNPG--------------TLDTEEG-GTGLDNARERLR 315
Cdd:cd16957     1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGqgipeerldllgktTVTSEKGtGTALENLNRRLI 80

                          90       100
                  ....*....|....*....|....*.
gi 2084127551 316 LLFGTEASLTVENTDAETVSATAVLP 341
Cdd:cd16957    81 GLFGSEACLHIESEVHGGTEVWFVIP 106
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
110-344 4.74e-10

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 59.25  E-value: 4.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 110 IGMLLASVVNMWILLMLWSLIYFGVHYFWSYRQAEVDKWKLEAQAETARLK------------------ALKLQLNphff 171
Cdd:COG4585     2 LALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEerrriarelhdgvgqslsAIKLQLE---- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 172 fnslnSVRALIAEDPDGAQRMVTRLARLLRSTLQ-----ADDMKTVPLEEE--LSTVRTYLKlekvRFEDRLRHRIEVDD 244
Cdd:COG4585    78 -----AARRLLDADPEAAREELEEIRELAREALAelrrlVRGLRPPALDDLglAAALEELAE----RLLRAAGIRVELDV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 245 EARSHPVP-------FMLVQTLVENGIKHGvaccqEGGVITVRGRVVDGALHIRVTNPGT-LDTEE---GGTGLDNARER 313
Cdd:COG4585   149 DGDPDRLPpevelalYRIVQEALTNALKHA-----GATRVTVTLEVDDGELTLTVRDDGVgFDPEAapgGGLGLRGMRER 223

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2084127551 314 LRLLFGTeasLTVENTDAETVSATAVLPVRA 344
Cdd:COG4585   224 AEALGGT---LTIGSAPGGGTRVRATLPLAA 251
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 251-321 7.54e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 49.77  E-value: 7.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 251 VPFMLVQTLVENGIKHGVACCQEGGVITVRGRV-VDGALHIRVTNPG------------TLDTEEGGTGLDNARERLRLL 317
Cdd:cd16955     1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGigispkvierveQDEMPGNKIGLLNVHQRLKLG 80


                  ....
gi 2084127551 318 FGTE 321
Cdd:cd16955    81 YGEG 84
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
189-307 3.06e-05

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 44.90  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 189 AQRMVTRLARLLR-STLQADDMK----TVPLEEELSTVRTYLKLekvRFEDRlRHRIEVDDEARSHPV---PFMLVQT-- 258
Cdd:COG2205    63 AERLLRLIEDLLDlSRLESGKLSlelePVDLAELLEEAVEELRP---LAEEK-GIRLELDLPPELPLVyadPELLEQVla 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2084127551 259 -LVENGIKHGvaccQEGGVITVRGRVVDGALHIRVTNPG------------------TLDTEEGGTGL 307
Cdd:COG2205   139 nLLDNAIKYS----PPGGTITISARREGDGVRISVSDNGpgipeeeleriferfyrgDNSRGEGGTGL 202
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 255-343 9.52e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 41.10  E-value: 9.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551  255 LVQTLVENGIKHgvacCQEGGVITVRGRVVDGALHIRVTNPG-------------------TLDTEEGGT--GLDNARER 313
Cdd:smart00387   9 VLSNLLDNAIKY----TPEGGRITVTLERDGDHVEITVEDNGpgippedlekifepffrtdKRSRKIGGTglGLSIVKKL 84

                           90       100       110
                   ....*....|....*....|....*....|
gi 2084127551  314 LRLLFGTeasLTVENTDAETVSATAVLPVR 343
Cdd:smart00387  85 VELHGGE---ISVESEPGGGTTFTITLPLE 111
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 253-341 2.96e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 39.07  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 253 FMLVQTLVENGIKHGvaccqEGGVITVRGRVVDGALHIRVTN-----PGTLDTEEGGTGLDNARERLRLLFGTeasLTVE 327
Cdd:cd16917     2 YRIVQEALTNALKHA-----GASRVRVTLSYTADELTLTVVDdgvgfDGPAPPGGGGFGLLGMRERAELLGGT---LTIG 73

                          90
                  ....*....|....
gi 2084127551 328 NTDAETVSATAVLP 341
Cdd:cd16917    74 SRPGGGTRVTARLP 87
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
182-296 1.27e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 40.31  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 182 IAEDPDGAQRMVT-------RLARLLR-----STLQADDMK----TVPLEEELSTVRTYLKLekvRFEDRlRHRIEVDDE 245
Cdd:COG5002   194 AADDPEERREYLEiileeaeRLSRLVNdlldlSRLESGELKlekePVDLAELLEEVVEELRP---LAEEK-GIELELDLP 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2084127551 246 ARSHPV---PFMLVQT---LVENGIKHGvaccQEGGVITVRGRVVDGALHIRVTNPG 296
Cdd:COG5002   270 EDPLLVlgdPDRLEQVltnLLDNAIKYT----PEGGTITVSLREEDDQVRISVRDTG 322
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
175-307 2.62e-03

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 39.51  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 175 LNSVRA---LIAEDPDGAQRM--------VTRLARLLRSTLQ---------ADDMKTVPLEEELSTVRTYLKLekvRFED 234
Cdd:COG0642   125 LTAIRGyleLLLEELDEEQREyletilrsADRLLRLINDLLDlsrleagklELEPEPVDLAELLEEVVELFRP---LAEE 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 235 RlRHRIEVDDEARSHPV---PFMLVQT---LVENGIKHGvaccQEGGVITVRGRVVDGALHIRVTNPG------------ 296
Cdd:COG0642   202 K-GIELELDLPDDLPTVrgdPDRLRQVllnLLSNAIKYT----PEGGTVTVSVRREGDRVRISVEDTGpgippedlerif 276

                         170
                  ....*....|....*..
gi 2084127551 297 ----TLD--TEEGGTGL 307
Cdd:COG0642   277 epffRTDpsRRGGGTGL 293
MCM3AP_GANP pfam16769
MCM3AP domain of GANP; MCM3AP_GANP is the C-terminal domain of germinal centre-associated ...
 132-260 5.51e-03

MCM3AP domain of GANP; MCM3AP_GANP is the C-terminal domain of germinal centre-associated proteins, GANPs in higher eukaryotes. GANP forms part of the TREX-2 complex which in higher eukaryotes requires the MCM3AP domain of GANP to facilitate its localization to the Nuclear pore complex and nuclear envelope. TREX-2 complex links transcription with nuclear messenger RNA export.


Pssm-ID: 465265  Cd Length: 717  Bit Score: 38.87  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 132 FGVHYFWSYRQAEVDKwklEAQAETARLKALKLQLNP-HFFFNSLNSVRALIAEDPdgaqrmvtrLARLLRSTLQADDMK 210
Cdd:pfam16769 525 FDPPSSWEQARLQTQK---EIQEQSQGRSGIKSAHPSaKSFPQSLFHSRQKGARSP---------EAGKEGRLPSAEDLT 592

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2084127551 211 TVPLEEELSTVR--TYLKLEKV---RFEDRLRHRIEVDDEAR--SHPVPFMLVQTLV 260
Cdd:pfam16769 593 HTASAEELLPQRlsSSLQLEKEeskRFEEQLQQWLSEDSEALldSTSLPLYLPQTLV 649
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 146-343 8.63e-03

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 37.91  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 146 DKWKLEAQAEtaRLKALK-----LQLNPHFFFNSLNSVRALI-AEDPDGAQRMVTRLARLLRSTLQADDMKT--VPLEEE 217
Cdd:COG3290   172 DRTELERLEE--ELEGVKelaeaLRAQRHDFRNHLHTISGLLqLGEYDEALEYIDEISEELQELIDSLLSRIgnPVLAAL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084127551 218 LSTVRTYLKLEKVRFEdrlrhrIEVDDEARSHPV-PFMLVQ---TLVENGIKHGVACCQEGGVITVRGRVVDGALHIRVT 293
Cdd:COG3290   250 LLGKAARARERGIDLT------IDIDSDLPDLPLsDTDLVTilgNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVE 323

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2084127551 294 NPG-----------------TLDTEEGGTGLDNARERLRLLFGTeasLTVENTDAETVSATAVLPVR 343
Cdd:COG3290   324 DSGpgipeellekifergfsTKLGEGRGLGLALVKQIVEKYGGT---IEVESEEGEGTVFTVRLPKE 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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