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Conserved domains on  [gi|2079606807|gb|QYU72051|]
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eukaryotic translation initiation factor 3 subunit c, partial [Dichaetophora aff. facilis sp. 2 TKK-2021a]

Protein Classification

PCI domain-containing protein( domain architecture ID 12188609)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to eukaryotic translation initiation factor 3 subunits A and M, and Schizosaccharomyces pombe Cop9 signalosome complex subunit 4

Gene Ontology:  GO:0032991|GO:0032991
PubMed:  9644972|36094910|19683491|11495792
SCOP:  4000147

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 103-182 2.69e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 70.35  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606807  103 MLVKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHRSEPSRLQALAM 182
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLAQ 80
eIF-3c_N super family cl20295
Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian ...
 1-30 1.17e-13

Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA.


The actual alignment was detected with superfamily member pfam05470:

Pssm-ID: 428482  Cd Length: 593  Bit Score: 68.70  E-value: 1.17e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2079606807   1 HINLELLECVYLVSAMLLEIPYIAAHEFDA 30
Cdd:pfam05470 564 HINLELLECVYLTCAMLLEIPYMAAHESDA 593
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 103-182 2.69e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 70.35  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606807  103 MLVKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHRSEPSRLQALAM 182
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLAQ 80
eIF-3c_N pfam05470
Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian ...
 1-30 1.17e-13

Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA.


Pssm-ID: 428482  Cd Length: 593  Bit Score: 68.70  E-value: 1.17e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2079606807   1 HINLELLECVYLVSAMLLEIPYIAAHEFDA 30
Cdd:pfam05470 564 HINLELLECVYLTCAMLLEIPYMAAHESDA 593
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 102-171 8.60e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 53.76  E-value: 8.60e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606807 102 EMLVKFIKEESLRTYLFTYSnvytSISIPSLAQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHR 171
Cdd:pfam01399  40 EDLRRKIREHNLRQLSKPYS----SISLSDLAKLLGLSVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 103-182 2.69e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 70.35  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606807  103 MLVKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHRSEPSRLQALAM 182
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEPLAQ 80
eIF-3c_N pfam05470
Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian ...
 1-30 1.17e-13

Eukaryotic translation initiation factor 3 subunit 8 N-terminus; The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA.


Pssm-ID: 428482  Cd Length: 593  Bit Score: 68.70  E-value: 1.17e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2079606807   1 HINLELLECVYLVSAMLLEIPYIAAHEFDA 30
Cdd:pfam05470 564 HINLELLECVYLTCAMLLEIPYMAAHESDA 593
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 102-171 8.60e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 53.76  E-value: 8.60e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606807 102 EMLVKFIKEESLRTYLFTYSnvytSISIPSLAQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHR 171
Cdd:pfam01399  40 EDLRRKIREHNLRQLSKPYS----SISLSDLAKLLGLSVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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