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Conserved domains on  [gi|2079606143|gb|QYU71719|]
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adenylosuccinate synthetase, partial [Mycodrosophila gratiosa]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt super family cl46237
Adenylosuccinate synthetase;
1-93 2.74e-38

Adenylosuccinate synthetase;


The actual alignment was detected with superfamily member pfam00709:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 131.70  E-value: 2.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI---KVDVDAELLRYKDYAERVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606143  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
1-93 2.74e-38

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 131.70  E-value: 2.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI---KVDVDAELLRYKDYAERVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606143  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
PLN02513 PLN02513
adenylosuccinate synthase
 1-93 1.12e-32

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 117.05  E-value: 1.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSIKVD---VDAELLRYKDYAERVRPYVKDTICFLHTAL 77
Cdd:PLN02513  135 IGPAYSSKATRNGLRVGDLR-HMDTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEAI 213

                          90
                  ....*....|....*.
gi 2079606143  78 RNGKTILVEGANAAML 93
Cdd:PLN02513  214 QAGKKILVEGAQATML 229
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 1-93 1.77e-26

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 100.09  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI----KVDVDAELLRYKDYAERVRPYVKDTICFLHTA 76
Cdd:COG0104   131 IGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEA 209

                          90
                  ....*....|....*..
gi 2079606143  77 LRNGKTILVEGANAAML 93
Cdd:COG0104   210 LKAGKKVLFEGAQGTLL 226
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-93 1.72e-14

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 66.37  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGEllgdfnlfsekfksivsthlrlfpsikvdvdaellrykdyaervrPYVKDTICFLHTALRNG 80
Cdd:cd03108   132 IGPAYADKAARTGIRVGD---------------------------------------------PYVVDTVELLNEALKAG 166

                          90
                  ....*....|...
gi 2079606143  81 KTILVEGANAAML 93
Cdd:cd03108   167 KKVLFEGAQGTLL 179
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
1-93 2.74e-38

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 131.70  E-value: 2.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI---KVDVDAELLRYKDYAERVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606143  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
PLN02513 PLN02513
adenylosuccinate synthase
 1-93 1.12e-32

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 117.05  E-value: 1.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSIKVD---VDAELLRYKDYAERVRPYVKDTICFLHTAL 77
Cdd:PLN02513  135 IGPAYSSKATRNGLRVGDLR-HMDTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEAI 213

                          90
                  ....*....|....*.
gi 2079606143  78 RNGKTILVEGANAAML 93
Cdd:PLN02513  214 QAGKKILVEGAQATML 229
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-93 5.50e-32

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 115.13  E-value: 5.50e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSIKVDVDAELLRYKDYAERVRPYVKDTICFLHTALRNG 80
Cdd:PTZ00350  146 IGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEG 224

                          90
                  ....*....|...
gi 2079606143  81 KTILVEGANAAML 93
Cdd:PTZ00350  225 KRVLVEGANATML 237
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 1-93 1.77e-26

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 100.09  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI----KVDVDAELLRYKDYAERVRPYVKDTICFLHTA 76
Cdd:COG0104   131 IGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEA 209

                          90
                  ....*....|....*..
gi 2079606143  77 LRNGKTILVEGANAAML 93
Cdd:COG0104   210 LKAGKKVLFEGAQGTLL 226
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-93 8.53e-24

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 92.80  E-value: 8.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI----KVDVDAELLRYKDYAERVRPYVKDTICFLHTA 76
Cdd:PRK01117  133 IGPAYEDKVARRGIRVGDLL-DPETFAEKLEENLEYKNFLLTKYygaeAVDFEEILDEYLEYAERLKPYVTDTSLLLNDA 211

                          90
                  ....*....|....*..
gi 2079606143  77 LRNGKTILVEGANAAML 93
Cdd:PRK01117  212 LKAGKRVLFEGAQGTLL 228
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-93 1.72e-14

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 66.37  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGEllgdfnlfsekfksivsthlrlfpsikvdvdaellrykdyaervrPYVKDTICFLHTALRNG 80
Cdd:cd03108   132 IGPAYADKAARTGIRVGD---------------------------------------------PYVVDTVELLNEALKAG 166

                          90
                  ....*....|...
gi 2079606143  81 KTILVEGANAAML 93
Cdd:cd03108   167 KKVLFEGAQGTLL 179
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-93 3.93e-11

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 57.12  E-value: 3.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIV-----STHLRLFPSIKVDVdAELLRYKDYaerVRPYVKDTICFLHT 75
Cdd:PRK13788  125 IGPAYSDRARRVGIRFGDLL-DEAVLRERVERLLeakpnSTREAGWDTVEKAL-ADLAPMREI---LLPFIADTGSLLRE 199

                          90
                  ....*....|....*...
gi 2079606143  76 ALRNGKTILVEGANAAML 93
Cdd:PRK13788  200 AIREGKRVLFEGAQATLL 217
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 1-88 1.73e-08

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 49.76  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLFPSI----------KVDVDAELLRYKDYAERVRPYVKDTI 70
Cdd:PRK13785  131 IGPTYEDKAGRRGVRVGDLL-DPDVLRDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEEDMTVN 209

                          90       100
                  ....*....|....*....|
gi 2079606143  71 C--FLHTALRNGKTILVEGA 88
Cdd:PRK13785  210 AgdFLAERIDDGDNVMLEGA 229
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-93 4.93e-08

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 48.41  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLGdfNLFSEKFKSIVSTHLR-------LFPSIKVDVDAELlryKDYAERVRPYVKDTICFL 73
Cdd:PRK13787  134 IGICYADKMMRTGLRVGDLLD--KSYKRRLKHLVDEKNReldklygMPPVSYNDINDGL---KFFLSKVGKNIINTAYYL 208

                          90       100
                  ....*....|....*....|
gi 2079606143  74 HTALRNGKTILVEGANAAML 93
Cdd:PRK13787  209 DTELKKGKRVLLEGAQGTGL 228
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 1-93 6.07e-06

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 42.40  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGElLGDFNLFSEKFKSIVSTHLRLFpSIKVDVDAELLRYKDYAERVRPYVKDTIcFLHTALRNg 80
Cdd:PRK13783  131 IGPAYADKVMRVGVRLAD-LFDEEKLREFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPV-EIKRILEE- 206

                          90
                  ....*....|...
gi 2079606143  81 KTILVEGANAAML 93
Cdd:PRK13783  207 KSVLFEGTQGVLL 219
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 1-93 7.80e-06

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 42.09  E-value: 7.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606143   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVSTHLRLF------PSIKVDvDAELLRYKDYAERVRPYVKDTICFLH 74
Cdd:PRK13786  131 IGFAYIDKIARDEVRMSDLV-DKERLMRRLEELAPQKEKEIkelggdPSIVRD-EALIDKYLELGRQLAPYITDVSYEIN 208

                          90
                  ....*....|....*....
gi 2079606143  75 TALRNGKTILVEGANAAML 93
Cdd:PRK13786  209 KALDEGKSVLAEGAQGTHL 227
GpmA COG0588
Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]; ...
 47-85 8.79e-03

Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]; Phosphoglycerate mutase (BPG-dependent) is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440353  Cd Length: 229  Bit Score: 33.52  E-value: 8.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2079606143  47 DVDAELLRY----KDYAERVRPYVKDTICflhTALRNGKTILV 85
Cdd:COG0588   139 DLPPAELPLteslKDTVARVLPYWEEEIA---PALKAGKRVLI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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